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https://www.readbyqxmd.com/read/29781079/the-role-of-new-adipokines-in-gestational-diabetes-mellitus-pathogenesis
#1
Radzisław Mierzyński, Elżbieta Poniedziałek-Czajkowska, Dominik Dłuski, Bożena Leszczyńska-Gorzelak
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition dur-ing pregnancy. Explanation of the GDM pathogenesis is important due to preventing gestational complications. During pregnancy there are significant changes in maternal metabolism. Many of these changes are influenced by different adi-pokines produced in the placenta and adipose tissue. The exact role of adipokines in the pathogenesis of GDM remains still unknown. Several adipokines have been analysed throughout gestation and their levels have been suggested as biomarkers of maternal-perinatal outcomes...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29733904/c1qtnf1-attenuates-angiotensin-ii-induced-cardiac-hypertrophy-via-activation-of-the-ampka-pathway
#2
Leiming Wu, Lu Gao, Dianhong Zhang, Rui Yao, Zhen Huang, Binbin Du, Zheng Wang, Lili Xiao, Pengcheng Li, Yapeng Li, Cui Liang, Yanzhou Zhang
RATIONALE: Complement C1q tumor necrosis factor related proteins (C1QTNFs) have been reported to have diverse biological influence on the cardiovascular system. C1QTNF1 is a member of the CTRP superfamily. C1QTNF1 is expressed in the myocardium; however, its function in myocytes has not yet been investigated. OBJECTIVE: To systematically investigate the roles of C1QTNF1 in angiotensin II (Ang II)-induced cardiac hypertrophy. METHODS AND RESULTS: C1QTNF1 knock-out mice were used with the aim of determining the role of C1QTNF1 in cardiac hypertrophy in the adult heart...
May 4, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29717906/relationship-of-selected-adipokines-with-markers-of-vascular-damage-in-patients-with-type-2-diabetes
#3
Jaromíra Spurná, David Karásek, Veronika Kubíčková, Dominika Goldmannová, Ondřej Krystyník, Jan Schovánek, Josef Zadražil
BACKGROUND: In this study we compared levels of selected adipokines between patients with type 2 diabetes (T2D) and healthy individuals and we determined their relationship with early vascular damage markers. METHODS: Seventy-seven subjects: 56 patients with T2D (34 men and 22 women) and 21 healthy controls (8 men and 13 women) were examined in this cross-sectional study. Selected adipokines [adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP-9), and allograft inflammatory factor-1 (AIF-1)] with possible cardiovascular impact were measured in all participants...
May 2, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29688307/rwen-response-weighted-elastic-net-for-prediction-of-chemosensitivity-of-cancer-cell-lines
#4
Amrita Basu, Ritwik Mitra, Han Liu, Stuart L Schreiber, Paul A Clemons
Motivation: In recent years there have been several efforts to generate sensitivity profiles of collections of genomically characterized cell lines to panels of candidate therapeutic compounds. These data provide the basis for the development of in silico models of sensitivity based on cellular, genetic, or expression biomarkers of cancer cells. However, a remaining challenge is an efficient way to identify accurate sets of biomarkers to validate. To address this challenge, we developed methodology using gene-expression profiles of human cancer cell lines to predict the responses of these cell lines to a panel of compounds...
April 24, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29063114/-research-progress-of-complement-c1q-tumor-necrosis-factor-related-protein-3
#5
Cheng-Lin Zhang, Li-Ling Wu, Li Li
Complement-C1q/tumor necrosis factor-related protein 3 (CTRP3) is an adipokine that primarily identified in 2003 and is an important member of CTRP family. CTRP3 is expressed in various tissues and cell types, and is highly conserved among different species. Multiple novel functions of CTRP3 have been reported recently as the further research on this protein develops. CTRP3 not only affects the proliferation of chondrocytes and the pathogenesis of osteoarthritis, but also regulates multiple physiological and pathological processes including the secretion of testosterone and adipokines, glucose and lipid metabolism, mitochondrial biogenesis, inflammatory response, cell apoptosis, angiogenesis, vascular calcification and ventricular remodeling...
October 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28966993/correlating-chemical-sensitivity-with-low-level-activation-of-mechanotransduction-pathways-in-hematologic-malignancies
#6
COMMENT
Robert G Hawley
Large-scale screening has revealed that human hematopoietic cancer cell lines are generally more sensitive to various classes of drugs than cell lines established from solid tumors. A detailed examination of data in the Cancer Therapeutics Response Portal (http://portals.broadinstitute.org/ctrp/) suggests that this enhanced sensitivity is due to lower basal levels of activation of TAZ-TEAD mechanotransduction pathways in hematopoietic versus non-hematopoietic cells. Translation inhibitors such as omacetaxine mepesuccinate (homoharringtonine) fall into this category of hematopoietic-selective compounds...
July 2017: Exploratory Research and Hypothesis in Medicine
https://www.readbyqxmd.com/read/28902432/c1q-tnf-related-protein-9-improves-the-anti-contractile-effects-of-perivascular-adipose-tissue-via-the-ampk-enos-pathway-in-diet-induced-obese-mice
#7
Fang Han, Yang Zhang, Mingxia Shao, Qingjie Mu, Xiaotong Jiao, Ningning Hou, Xiaodong Sun
The anti-contractile property of perivascular adipose tissue (PVAT) is abolished through an endothelium-dependent pathway in obesity. C1q/tumor necrosis factor-related protein (CTRP)9 improved endothelial function by promoting endothelium-dependent vasodilatation. The aims of this study were to investigate whether CTRP9 improves the anti-contractile effect of PVAT and protects against PVAT dysfunction in obese mice. The mice were treated with a high-fat diet with or without CTRP9 treatment. Thoracic aortas with or without PVAT (PVAT+ or PVAT-) were prepared, and concentration-dependent responses to phenylephrine were measured...
January 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28754090/association-of-serum-c1q-tnf-related-protein-3-ctrp-3-in-patients-with-coronary-artery-disease
#8
Shuhong Wang, Yuan Ling, Wei Liang, Linhui Shen
BACKGROUND: Recent studies have demonstrated that complement C1q tumor necrosis factor related proteins (CTRPs) have diverse biological influences on the cardiovascular system. CTRP 3 is a member of the CTRP superfamily, which may play a pivotal role in the pathogenesis of coronary artery disease (CAD). Here, we investigated whether serum levels of CTRP 3 are associated with the prevalence and the severity of CAD. METHODS: In this study, 145 eligible participants were included who underwent coronary angiography...
July 28, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28640446/c1q-tnf-related-protein-3-ctrp3-function-and-regulation
#9
REVIEW
Ying Li, Gary L Wright, Jonathan M Peterson
As the largest endocrine organ, adipose tissue secretes many bioactive molecules that circulate in blood, collectively termed adipokines. Efforts to identify such metabolic regulators have led to the discovery of a family of secreted proteins, designated as C1q tumor necrosis factor (TNF)-related proteins (CTRPs). The CTRP proteins, adiponectin, TNF-alpha, as well as other proteins with the distinct C1q domain are collectively grouped together as the C1q/TNF superfamily. Reflecting profound biological potency, the initial characterization of these adipose tissue-derived CTRP factors finds wide-ranging effects upon metabolism, inflammation, and survival-signaling in multiple tissue types...
June 18, 2017: Comprehensive Physiology
https://www.readbyqxmd.com/read/28625919/c1q-tnf-related-protein-1-promotes-endothelial-barrier-dysfunction-under-disturbed-flow
#10
Zhu Hui Liu, Chang Li, Jia Wei Chen, Ying Shen, Jie Gao, Wei Feng Shen, Rui Yan Zhang, Xiao Qun Wang, Lin Lu
Endothelial hyper-permeability is a major determinant factor that contributes to the accelerated development of atherosclerotic lesions at hemodynamically disturbed sites. Previously, we showed that C1q/TNF related protein (CTRP) 1 promotes endothelium-leukocyte interactions and inflammatory responses in vascular cells. Here, we sought to investigate the role of CTRP1 in modulation of endothelial permeability under disturbed flow condition. By using en face staining of mouse aorta, we found CTRP1 expression was significantly increased in vascular endothelial cells under disturbed flow as compared to steady laminar flow...
August 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28617226/contextualization-of-drug-mediator-relations-using-evidence-networks
#11
Hai Joey Tran, Gil Speyer, Jeff Kiefer, Seungchan Kim
BACKGROUND: Genomic analysis of drug response can provide unique insights into therapies that can be used to match the "right drug to the right patient." However, the process of discovering such therapeutic insights using genomic data is not straightforward and represents an area of active investigation. EDDY (Evaluation of Differential DependencY), a statistical test to detect differential statistical dependencies, is one method that leverages genomic data to identify differential genetic dependencies...
May 31, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28283578/molecular-identification-and-functional-analysis-of-ctrp9-in-epinephelus-coioides
#12
Guokun Yang, Chaobin Qin, Bin Wang, Jirong Jia, Xi Yuan, Caiyun Sun, Wensheng Li
CTRP9 is a member of the C1q/TNF-related protein (CTRP) superfamily and has been studied in mammals, whereas the comparative studies of CTRP9 in non-mammalian species are still absent. In this study, ctrp9 was isolated and characterized from the orange-spotted grouper ( Epinephelus coioides ). The full-length cDNA of ctrp9 was 1378 bp in size with an ORF (open reading frame) of 1020 bp that encodes a 339 amino acid pre-pro hormone. The mRNA expression of ctrp9 showed a rather high level in the kidney and brain, but a low level in other tissues...
May 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28207876/circulating-c1q-complement-tnf-related-protein-ctrp-1-ctrp9-ctrp12-and-ctrp13-concentrations-in-type-2-diabetes-mellitus-in-vivo-regulation-by-glucose
#13
COMPARATIVE STUDY
Bo Bai, Bo Ban, Zunjing Liu, Man Man Zhang, Bee Kang Tan, Jing Chen
OBJECTIVES: The C1q complement/TNF-related protein (CTRP) superfamily, which includes the adipokine adiponectin, has been shown in animal models to have positive metabolic and cardiovascular effects. We sought to investigate circulating CTRP1, CTRP9, CTRP12 and CTRP13 concentrations in persons with type 2 diabetes mellitus (T2DM), with age and BMI matched controls, and to examine the effects of a 2 hour 75g oral glucose tolerance test (OGTT) on serum CTRP1, CTRP9, CTRP12 and CTRP13 levels in persons with T2DM...
2017: PloS One
https://www.readbyqxmd.com/read/28131048/c1q-tnf-related-protein-1-prevents-neointimal-formation-after-arterial-injury
#14
Noriyoshi Kanemura, Rei Shibata, Koji Ohashi, Hayato Ogawa, Mizuho Hiramatsu-Ito, Takashi Enomoto, Daisuke Yuasa, Masanori Ito, Satoko Hayakawa, Naoya Otaka, Toyoaki Murohara, Noriyuki Ouchi
BACKGROUND AND AIMS: Obesity contributes to the progression of vascular disorders. C1q/TNF-related protein (CTRP) 1 is a circulating adipokine, which is upregulated in obese complications including coronary artery disease. Here, we investigated the role of CTRP1 in regulation of vascular remodeling after mechanical injury and evaluated its potential mechanism. METHODS: Mice were subjected to wire-induced injury of left femoral arteries. An adenoviral vector encoding CTRP1 (Ad-CTRP1) or β-galactosidase as a control was injected into the jugular vein of mice 3 days prior to surgery...
February 2017: Atherosclerosis
https://www.readbyqxmd.com/read/27930815/ctrp-3-is-permeable-to-the-blood-brain-barrier-and-is-not-regulated-by-glucose-or-lipids-in-vivo
#15
COMPARATIVE STUDY
Andreas Schmid, Martin Berghoff, Alexandra Hochberg, Andreas Schäffler, Thomas Karrasch
BACKGROUND: C1q/TNF-related protein-3 (CTRP-3) represents a novel anti-inflammatory and antidiabetic adipokine secreted by adipose tissue. The physiological and postprandial regulation of CTRP-3 remains obscure and it is not known whether CTRP-3 is permeable to the brain. The postprandial regulation of CTRP-3 during an oral glucose tolerance test (n = 100) and an oral lipid tolerance test (n = 100) in humans was investigated. Moreover, CTRP-3 concentrations were measured in paired serum and cerebrospinal fluid (CSF) samples of patients (n = 270) undergoing neurological evaluation...
March 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27897001/differential-pathway-dependency-discovery-associated-with-drug-response-across-cancer-cell-lines
#16
Gil Speyer, Divya Mahendra, Hai J Tran, Jeff Kiefer, Stuart L Schreiber, Paul A Clemons, Harshil Dhruv, Michael Berens, Seungchan Kim
The effort to personalize treatment plans for cancer patients involves the identification of drug treatments that can effectively target the disease while minimizing the likelihood of adverse reactions. In this study, the gene-expression profile of 810 cancer cell lines and their response data to 368 small molecules from the Cancer Therapeutics Research Portal (CTRP) are analyzed to identify pathways with significant rewiring between genes, or differential gene dependency, between sensitive and non-sensitive cell lines...
2017: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27863353/association-of-increased-serum-ctrp5-levels-with-in-stent-restenosis-after-coronary-drug-eluting-stent-implantation-ctrp5-promoting-inflammation-migration-and-proliferation-in-vascular-smooth-muscle-cells
#17
Ying Shen, Chang Li, Rui Yan Zhang, Qi Zhang, Wei Feng Shen, Feng Hua Ding, Lin Lu
BACKGROUND: We investigated whether serum level of C1q/TNF-related protein (CTRP) 5 is associated with in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation, and assessed the biological effects of CTRP5 in human aortic smooth muscle cells (hASMCs). METHODS AND RESULTS: Serum CTRP5 levels were assayed in 306 patients with and 306 patients without angiographic ISR at approximately one year after DES-based PCI...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27856277/c1q-tumor-necrosis-factor-related-protein-3-inhibits-oxidative-stress-during-intracerebral-hemorrhage-via-pka-signaling
#18
Bo Yang, Shaohua Wang, Shanshan Yu, Yanlin Chen, Linyu Li, Hui Zhang, Yong Zhao
C1q/tumor necrosis factor (TNF)-related proteins (CTRPs) have been confirmed to be adiponectin (APN) paralogs and some share APN's metabolic regulatory functions. Oxidative stress contributes to brain injury after intracerebral hemorrhage (ICH) and APN can inhibit oxidative stress injury during ICH. Thus, we addressed the role of a specific CTRP-CTRP 3-after experimental ICH and studied post-ICH oxidative stress injury and the pathway involved. ICH was induced in rats via intracerebral infusion of autologous blood, and the effects of exogenous CTRP3 (lentivirus or recombinant CTRP3) replenishment on ICH injury were investigated...
February 15, 2017: Brain Research
https://www.readbyqxmd.com/read/27738641/plasma-c1q-tnf-related-protein-3-ctrp-3-and-high-mobility-group-box-1-hmgb-1-concentrations-in-subjects-with-prediabetes-and-type-2-diabetes
#19
Huili Wei, Hua Qu, Hang Wang, Huacong Deng
Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM). Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT, n = 62), pre-DM (n = 111), and nT2DM group (n = 56). Results...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27590487/c1q-tnf-related-protein-3-expression-and-effects-on-adipocyte-differentiation-of-3t3-l1-cells
#20
Hiroki Nishimoto, Akihiro Yamamoto, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Adipose tissue-derived adipokines influence a number of organs critical for energy homeostasis and metabolism. One of the most extensively studied adipokines is adiponectin, which exerts anti-diabetic, anti-inflammatory, and anti-atherogenic functions on various cell types. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 reduces hepatic triglyceride levels in diet-induced obese (DIO) mice. However, the physiological role of CTRP3 in adipocytes is largely unknown...
February 2017: Cell Biology International
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