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Guokun Yang, Chaobin Qin, Bin Wang, Jirong Jia, Xi Yuan, Caiyun Sun, Wensheng Li
CTRP9 is a member of the C1q/TNF-related protein (CTRP) superfamily and has been studied in mammals, while the comparative studies of CTRP9 in non-mammalian species are still absent. In this study, CTRP9 was isolated and characterized from the orange-spotted grouper (Epinephelus coioides). The full length cDNA of CTRP9 was 1378 bp in size with ORF (open reading frame) of 1020 bp which encods a 339 amino acids preprohormone. The mRNA expression of CTRP9 showed a rather high level in the kidney and brain, but low level in other tissues...
March 10, 2017: Journal of Molecular Endocrinology
Bo Bai, Bo Ban, Zunjing Liu, Man Man Zhang, Bee Kang Tan, Jing Chen
OBJECTIVES: The C1q complement/TNF-related protein (CTRP) superfamily, which includes the adipokine adiponectin, has been shown in animal models to have positive metabolic and cardiovascular effects. We sought to investigate circulating CTRP1, CTRP9, CTRP12 and CTRP13 concentrations in persons with type 2 diabetes mellitus (T2DM), with age and BMI matched controls, and to examine the effects of a 2 hour 75g oral glucose tolerance test (OGTT) on serum CTRP1, CTRP9, CTRP12 and CTRP13 levels in persons with T2DM...
2017: PloS One
Noriyoshi Kanemura, Rei Shibata, Koji Ohashi, Hayato Ogawa, Mizuho Hiramatsu-Ito, Takashi Enomoto, Daisuke Yuasa, Masanori Ito, Satoko Hayakawa, Naoya Otaka, Toyoaki Murohara, Noriyuki Ouchi
BACKGROUND AND AIMS: Obesity contributes to the progression of vascular disorders. C1q/TNF-related protein (CTRP) 1 is a circulating adipokine, which is upregulated in obese complications including coronary artery disease. Here, we investigated the role of CTRP1 in regulation of vascular remodeling after mechanical injury and evaluated its potential mechanism. METHODS: Mice were subjected to wire-induced injury of left femoral arteries. An adenoviral vector encoding CTRP1 (Ad-CTRP1) or β-galactosidase as a control was injected into the jugular vein of mice 3 days prior to surgery...
February 2017: Atherosclerosis
Andreas Schmid, Martin Berghoff, Alexandra Hochberg, Andreas Schäffler, Thomas Karrasch
BACKGROUND: C1q/TNF-related protein-3 (CTRP-3) represents a novel anti-inflammatory and antidiabetic adipokine secreted by adipose tissue. The physiological and postprandial regulation of CTRP-3 remains obscure and it is not known whether CTRP-3 is permeable to the brain. The postprandial regulation of CTRP-3 during an oral glucose tolerance test (n = 100) and an oral lipid tolerance test (n = 100) in humans was investigated. Moreover, CTRP-3 concentrations were measured in paired serum and cerebrospinal fluid (CSF) samples of patients (n = 270) undergoing neurological evaluation...
December 8, 2016: European Journal of Clinical Investigation
Gil Speyer, Divya Mahendra, Hai J Tran, Jeff Kiefer, Stuart L Schreiber, Paul A Clemons, Harshil Dhruv, Michael Berens, Seungchan Kim
The effort to personalize treatment plans for cancer patients involves the identification of drug treatments that can effectively target the disease while minimizing the likelihood of adverse reactions. In this study, the gene-expression profile of 810 cancer cell lines and their response data to 368 small molecules from the Cancer Therapeutics Research Portal (CTRP) are analyzed to identify pathways with significant rewiring between genes, or differential gene dependency, between sensitive and non-sensitive cell lines...
2016: Pacific Symposium on Biocomputing
Ying Shen, Chang Li, Rui Yan Zhang, Qi Zhang, Wei Feng Shen, Feng Hua Ding, Lin Lu
BACKGROUND: We investigated whether serum level of C1q/TNF-related protein (CTRP) 5 is associated with in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation, and assessed the biological effects of CTRP5 in human aortic smooth muscle cells (hASMCs). METHODS AND RESULTS: Serum CTRP5 levels were assayed in 306 patients with and 306 patients without angiographic ISR at approximately one year after DES-based PCI...
February 1, 2017: International Journal of Cardiology
Bo Yang, Shaohua Wang, Shanshan Yu, Yanlin Chen, Linyu Li, Hui Zhang, Yong Zhao
C1q/tumor necrosis factor (TNF)-related proteins (CTRPs) have been confirmed to be adiponectin (APN) paralogs and some share APN's metabolic regulatory functions. Oxidative stress contributes to brain injury after intracerebral hemorrhage (ICH) and APN can inhibit oxidative stress injury during ICH. Thus, we addressed the role of a specific CTRP-CTRP 3-after experimental ICH and studied post-ICH oxidative stress injury and the pathway involved. ICH was induced in rats via intracerebral infusion of autologous blood, and the effects of exogenous CTRP3 (lentivirus or recombinant CTRP3) replenishment on ICH injury were investigated...
November 14, 2016: Brain Research
Huili Wei, Hua Qu, Hang Wang, Huacong Deng
Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM). Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT, n = 62), pre-DM (n = 111), and nT2DM group (n = 56). Results...
2016: Journal of Diabetes Research
Hiroki Nishimoto, Akihiro Yamamoto, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Adipose tissue-derived adipokines influence a number of organs critical for energy homeostasis and metabolism. One of the most extensively studied adipokines is adiponectin, which exerts anti-diabetic, anti-inflammatory, and anti-atherogenic functions on various cell types. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 reduces hepatic triglyceride levels in diet-induced obese (DIO) mice. However, the physiological role of CTRP3 in adipocytes is largely unknown...
February 2017: Cell Biology International
Magdalena Sawicka, Joanna Janowska, Jerzy Chudek
Obesity is a risk factor of cardiovascular diseases. However, in the case of heart failure, obese and overweight patients have a more favourable prognosis compared to patients who have a normal body weight. This phenomenon is referred to as the "obesity paradox," and it is explained by, among others, a positive effect of adipokines produced by adipose tissue, particularly by the tissue located in the direct vicinity of the heart and blood vessels. The favourable effect on the cardiovascular system is mostly associated with adiponectin and omentin, but the levels of these substances are reduced in obese patients...
November 1, 2016: International Journal of Cardiology
Thomas Klonisch, Aleksandra Glogowska, Thatchawan Thanasupawat, Maxwell Burg, Jerry Krcek, Marshall Pitz, Appalaraju Jaggupilli, Prashen Chelikani, G William Wong, Sabine Hombach-Klonisch
We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors...
July 22, 2016: British Journal of Pharmacology
Shuying Jia, Zhen Yang, Kexin Ren, Ziqi Tian, Chang Dong, Ruixue Ma, Ge Yu, Weiben Yang
Contamination of trace antibiotics is widely found in surface water sources. This work delineates removal of trace antibiotics (norfloxacin (NOR), sulfadiazine (SDZ) or tylosin (TYL)) from synthetic surface water by flocculation, in the coexistence of inorganic suspended particles (kaolin) and natural organic matter (humic acid, HA). To avoid extra pollution caused by petrochemical products-based modification reagents, environmental-friendly amino-acid-modified-chitosan flocculants, Ctrp and Ctyr, with different functional aromatic-rings structures were employed...
November 5, 2016: Journal of Hazardous Materials
Nikita Pozdeyev, Minjae Yoo, Ryan Mackie, Rebecca E Schweppe, Aik Choon Tan, Bryan R Haugen
The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows integration of heterogeneous drug sensitivity data from the CCLE, the GDSC, and the Cancer Therapeutics Response Portal (CTRP)...
August 9, 2016: Oncotarget
Xiao Qun Wang, Zhu Hui Liu, Lu Xue, Lin Lu, Jie Gao, Ying Shen, Ke Yang, Qiu Jing Chen, Rui Yan Zhang, Wei Feng Shen
BACKGROUND AND AIMS: Macrophage is a major contributor to the development of atherosclerosis by taking up deposited lipoprotein and eliciting local inflammation. Previously, we and others have shown C1q/TNF-related proteins (CTRPs) play diverse roles in vascular functions. In this study, we sought to investigate the changes in CTRP expression levels during vital biological processes in macrophages and their relation to inflammatory responses. METHODS: Western blot and real-time PCR were performed to analyze CTRPs expression levels in human peripheral blood mononuclear cells, primary macrophages and lipid-laden foam cells...
July 2016: Atherosclerosis
Huizhong Wang, Ru Wang, Dayong Du, Fangliang Li, Yuntian Li
BACKGROUND: Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, however, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD. METHODS: CTRP 1 levels of 150 CAD patients and 50 non-CAD subjects were determined by enzymelinked immunosorbent assay...
May 11, 2016: BMC Cardiovascular Disorders
Daisuke Yuasa, Koji Ohashi, Rei Shibata, Naoki Mizutani, Yoshiyuki Kataoka, Takahiro Kambara, Yusuke Uemura, Kazuhiro Matsuo, Noriyoshi Kanemura, Satoko Hayakawa, Mizuho Hiramatsu-Ito, Masanori Ito, Hayato Ogawa, Takashi Murate, Toyoaki Murohara, Noriyuki Ouchi
Obesity is associated with an increased risk of cardiovascular disease. C1q/TNF-related protein (CTRP)-1 is a poorly characterized adipokine that is up-regulated in association with ischemic heart disease. We investigated the role of CTRP1 in myocardial ischemia injury. CTRP1-knockout mice showed increased myocardial infarct size, cardiomyocyte apoptosis, and proinflammatory gene expression after I/R compared with wild-type (WT) mice. In contrast, systemic delivery of CTRP1 attenuated myocardial damage after I/R in WT mice...
March 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Diandian Li, Yanqiu Wu, Panwen Tian, Xue Zhang, Hao Wang, Tao Wang, Binwu Ying, Lanlan Wang, Yongchun Shen, Fuqiang Wen
Local and systemic inflammation often present in chronic obstructive pulmonary disease (COPD). Adipokines are secretory protein mediators by adipose tissue, which have been found to involve in inflammatory responses in many chronic inflammatory diseases. Therefore, we performed this preliminary clinical study to investigate the possible association between 2 adipokines, C1q/tumor necrosis factor-related protein-3 and -5 (CTRP-3 and CTRP-5), with lung function and other markers of inflammation in COPD. Serum CTRP-3 and CTRP-5 levels were measured in 73 COPD patients and 54 health controls, together with lung function and levels of adiponectin, CRP, TNF-α, and MPO in both groups...
September 2015: Medicine (Baltimore)
Thatchawan Thanasupawat, Aleksandra Glogowska, Maxwell Burg, G William Wong, Cuong Hoang-Vu, Sabine Hombach-Klonisch, Thomas Klonisch
The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
2015: Frontiers in Endocrinology
Masataka Otani, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Several hormones and growth factors, including adipokines, play important roles during muscle development and regeneration. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 is a novel adipokine previously reported to reduce glucose output in hepatocytes and lower glucose levels in mice models. In the present study, we provide the first evidence for a physiological role of the CTRP3 in myogenesis using C2C12 myoblasts. CTRP3 was expressed in developing skeletal muscle tissues, and the expression level of CTRP3 was increased during myogenic differentiation of C2C12 cells...
November 2015: Molecular and Cellular Biochemistry
Hua Qu, Min Deng, Hang Wang, Huili Wei, Fang Liu, Jing Wu, Huacong Deng
BACKGROUND: To analyze the association between the plasma C1q/TNF-related protein-3 (CTRP-3) concentrations, obesity, and type II diabetes in the Chinese population. METHODS: The plasma CTRP-3 concentrations were analyzed in 174 Chinese subjects with obesity (n = 43), type II diabetes (n = 41), obesity combined with type II diabetes (n = 45), and healthy subjects (n = 45), as were various clinical parameters of obesity-related metabolic disorders and adipokines...
May 2015: Journal of Clinical Lipidology
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