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Huili Wei, Hua Qu, Hang Wang, Huacong Deng
Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM). Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT, n = 62), pre-DM (n = 111), and nT2DM group (n = 56). Results...
2016: Journal of Diabetes Research
Hiroki Nishimoto, Akihiro Yamamoto, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Adipose tissue-derived adipokines influence a number of organs critical for energy homeostasis and metabolism. One of the most extensively studied adipokines is adiponectin, which exerts anti-diabetic, anti-inflammatory and anti-atherogenic functions on various cell types. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 reduces hepatic triglyceride levels in diet-induced obese (DIO) mice. However, the physiological role of CTRP3 in adipocytes is largely unknown...
September 3, 2016: Cell Biology International
Magdalena Sawicka, Joanna Janowska, Jerzy Chudek
Obesity is a risk factor of cardiovascular diseases. However, in the case of heart failure, obese and overweight patients have a more favourable prognosis compared to patients who have a normal body weight. This phenomenon is referred to as the "obesity paradox," and it is explained by, among others, a positive effect of adipokines produced by adipose tissue, particularly by the tissue located in the direct vicinity of the heart and blood vessels. The favourable effect on the cardiovascular system is mostly associated with adiponectin and omentin, but the levels of these substances are reduced in obese patients...
November 1, 2016: International Journal of Cardiology
Thomas Klonisch, Aleksandra Glogowska, Thatchawan Thanasupawat, Maxwell Burg, Jerry Krcek, Marshall Pitz, Appalaraju Jaggupilli, Prashen Chelikani, G William Wong, Sabine Hombach-Klonisch
We established the role of the GPCR relaxin/insulin-like family peptide receptor 1 (RXFP1 receptor) as a novel active receptor in human glioblastoma (GB), a fatal brain tumour. We identified C1q/TNF-related protein 8 (CTRP8) as a novel agonist of the RXFP1 receptor. CTRP8 enhanced the motility and matrix invasion of GB, and this involved PKC-mediated up-regulation of cathepsin B, a marker for poor prognosis in GB patients. We conclude that the absence of relaxin isoforms does not preclude the activation of the RXFP1 receptor, as the least known member of the CTRP family, CTRP8, can effectively target and activate RXFP1 receptors...
July 22, 2016: British Journal of Pharmacology
Shuying Jia, Zhen Yang, Kexin Ren, Ziqi Tian, Chang Dong, Ruixue Ma, Ge Yu, Weiben Yang
Contamination of trace antibiotics is widely found in surface water sources. This work delineates removal of trace antibiotics (norfloxacin (NOR), sulfadiazine (SDZ) or tylosin (TYL)) from synthetic surface water by flocculation, in the coexistence of inorganic suspended particles (kaolin) and natural organic matter (humic acid, HA). To avoid extra pollution caused by petrochemical products-based modification reagents, environmental-friendly amino-acid-modified-chitosan flocculants, Ctrp and Ctyr, with different functional aromatic-rings structures were employed...
November 5, 2016: Journal of Hazardous Materials
Nikita Pozdeyev, Minjae Yoo, Ryan Mackie, Rebecca E Schweppe, Aik Choon Tan, Bryan R Haugen
The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows integration of heterogeneous drug sensitivity data from the CCLE, the GDSC, and the Cancer Therapeutics Response Portal (CTRP)...
June 14, 2016: Oncotarget
Xiao Qun Wang, Zhu Hui Liu, Lu Xue, Lin Lu, Jie Gao, Ying Shen, Ke Yang, Qiu Jing Chen, Rui Yan Zhang, Wei Feng Shen
BACKGROUND AND AIMS: Macrophage is a major contributor to the development of atherosclerosis by taking up deposited lipoprotein and eliciting local inflammation. Previously, we and others have shown C1q/TNF-related proteins (CTRPs) play diverse roles in vascular functions. In this study, we sought to investigate the changes in CTRP expression levels during vital biological processes in macrophages and their relation to inflammatory responses. METHODS: Western blot and real-time PCR were performed to analyze CTRPs expression levels in human peripheral blood mononuclear cells, primary macrophages and lipid-laden foam cells...
July 2016: Atherosclerosis
Huizhong Wang, Ru Wang, Dayong Du, Fangliang Li, Yuntian Li
BACKGROUND: Complement C1q tumor necrosis factor related proteins (CTRPs) have been proved to have diverse biological influences on cardiovascular system. CTRP 1 is a member of the CTRP superfamily, however, the relevance with coronary artery disease (CAD) are seldom explored. This study was designed to investigate the correlation between serum levels of CTRP 1 and CAD. METHODS: CTRP 1 levels of 150 CAD patients and 50 non-CAD subjects were determined by enzymelinked immunosorbent assay...
2016: BMC Cardiovascular Disorders
Daisuke Yuasa, Koji Ohashi, Rei Shibata, Naoki Mizutani, Yoshiyuki Kataoka, Takahiro Kambara, Yusuke Uemura, Kazuhiro Matsuo, Noriyoshi Kanemura, Satoko Hayakawa, Mizuho Hiramatsu-Ito, Masanori Ito, Hayato Ogawa, Takashi Murate, Toyoaki Murohara, Noriyuki Ouchi
Obesity is associated with an increased risk of cardiovascular disease. C1q/TNF-related protein (CTRP)-1 is a poorly characterized adipokine that is up-regulated in association with ischemic heart disease. We investigated the role of CTRP1 in myocardial ischemia injury. CTRP1-knockout mice showed increased myocardial infarct size, cardiomyocyte apoptosis, and proinflammatory gene expression after I/R compared with wild-type (WT) mice. In contrast, systemic delivery of CTRP1 attenuated myocardial damage after I/R in WT mice...
March 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Diandian Li, Yanqiu Wu, Panwen Tian, Xue Zhang, Hao Wang, Tao Wang, Binwu Ying, Lanlan Wang, Yongchun Shen, Fuqiang Wen
Local and systemic inflammation often present in chronic obstructive pulmonary disease (COPD). Adipokines are secretory protein mediators by adipose tissue, which have been found to involve in inflammatory responses in many chronic inflammatory diseases. Therefore, we performed this preliminary clinical study to investigate the possible association between 2 adipokines, C1q/tumor necrosis factor-related protein-3 and -5 (CTRP-3 and CTRP-5), with lung function and other markers of inflammation in COPD. Serum CTRP-3 and CTRP-5 levels were measured in 73 COPD patients and 54 health controls, together with lung function and levels of adiponectin, CRP, TNF-α, and MPO in both groups...
September 2015: Medicine (Baltimore)
Thatchawan Thanasupawat, Aleksandra Glogowska, Maxwell Burg, G William Wong, Cuong Hoang-Vu, Sabine Hombach-Klonisch, Thomas Klonisch
The relaxin-like RXFP1 ligand-receptor system has important functions in tumor growth and tissue invasion. Recently, we have identified the secreted protein, CTRP8, a member of the C1q/tumor necrosis factor-related protein (CTRP) family, as a novel ligand of the relaxin receptor, RXFP1, with functions in brain cancer. Here, we review the role of CTRP members in cancers cells with particular emphasis on CTRP8 in glioblastoma.
2015: Frontiers in Endocrinology
Masataka Otani, Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Several hormones and growth factors, including adipokines, play important roles during muscle development and regeneration. CTRP3, a paralog of adiponectin, is a member of the C1q and tumor necrosis factor-related protein (CTRP) superfamily. CTRP3 is a novel adipokine previously reported to reduce glucose output in hepatocytes and lower glucose levels in mice models. In the present study, we provide the first evidence for a physiological role of the CTRP3 in myogenesis using C2C12 myoblasts. CTRP3 was expressed in developing skeletal muscle tissues, and the expression level of CTRP3 was increased during myogenic differentiation of C2C12 cells...
November 2015: Molecular and Cellular Biochemistry
Hua Qu, Min Deng, Hang Wang, Huili Wei, Fang Liu, Jing Wu, Huacong Deng
BACKGROUND: To analyze the association between the plasma C1q/TNF-related protein-3 (CTRP-3) concentrations, obesity, and type II diabetes in the Chinese population. METHODS: The plasma CTRP-3 concentrations were analyzed in 174 Chinese subjects with obesity (n = 43), type II diabetes (n = 41), obesity combined with type II diabetes (n = 45), and healthy subjects (n = 45), as were various clinical parameters of obesity-related metabolic disorders and adipokines...
May 2015: Journal of Clinical Lipidology
Takahiro Kambara, Rei Shibata, Koji Ohashi, Kazuhiro Matsuo, Mizuho Hiramatsu-Ito, Takashi Enomoto, Daisuke Yuasa, Masanori Ito, Satoko Hayakawa, Hayato Ogawa, Tamar Aprahamian, Kenneth Walsh, Toyoaki Murohara, Noriyuki Ouchi
Obesity is a risk factor for cardiovascular disease. C1q/tumor necrosis factor-related protein 9 (CTRP9) is an adipokine that is downregulated by obesity. We investigated the role of CTRP9 in cardiac injury with loss-of-function genetic manipulations and defined the receptor-mediated signaling pathway downstream of this adipokine. CTRP9-knockout (CTRP9-KO) mice at the age of 12 weeks were indistinguishable from wild-type (WT) mice under basal conditions. CTRP9-KO mice had exacerbated contractile left ventricle dysfunction following intraperitoneal injection of lipopolysaccharide (LPS) compared to WT mice...
June 2015: Molecular and Cellular Biology
T Karrasch, A Schmid, A Kopp, F Obermeier, C Hofmann, A Schäffler
BACKGROUND: Studies postulate an involvement of adipokines in inflammatory gastrointestinal diseases. Leptin-deficient ob/ob mice as well as TLR9-deficient mice have a more moderate course of chronic DSS-induced colitis (DSS-CC) and adipocytes do express functional TLR9 molecules. MATERIAL AND METHODS: Adipokine mRNA expression in visceral adipose tissue of mice before and after the induction of DSS-CC was investigated. Experiments were performed in both TLR9(wt/wt) and TLR9(-/-) mice...
February 2015: Experimental and Clinical Endocrinology & Diabetes
Jun-Nan Tang, De-Liang Shen, Cong-Lin Liu, Xiao-Fang Wang, Li Zhang, Xue-Xi Xuan, Ling-Ling Cui, Jin-Ying Zhang
BACKGROUND: C1q/TNF-related protein 1 (CTRP-1), a novel adipocyte factor, may participate in the mechanisms of metabolism and inflammation. Interleukin 6 (IL-6) is a proinflammatory cytokine that is correlated with the severity of coronary heart disease (CHD). In this study, we focused on the levels of CTRP-1 and IL-6 in patients with CHD. METHODS: Circulating CTRP-1 and IL-6 levels were measured using enzyme-linked immunosorbent assay in 81 patients with acute coronary syndrome (n=41) or stable angina pectoris (n=40)...
February 2015: American Journal of the Medical Sciences
Andreas Schmid, Andrea Kopp, Frank Hanses, Thomas Karrasch, Andreas Schäffler
BACKGROUND: The C1q/TNF-related proteins comprise a growing family of adiponectin paralogous proteins. CTRP-3 represents a novel adipokine with strong expression in adipose tissue and was shown to inhibit chemokine and cytokine release in adipocytes and monocytes in vitro. The aim of the study was to gain the proof of principle that CTRP-3 is a potent anti-inflammatory adipokine in vivo. METHODS: C57BL/6N mice were treated intraperitoneally (i.p.) with bacterial lipopolysaccharide (LPS) for 2h...
September 12, 2014: Biochemical and Biophysical Research Communications
Shaohui Lin, Shaojun Ma, Ping Lu, Wenwei Cai, Yi Chen, Jing Sheng
CTRP3, discovered as novel adipokines, is a member of the C1q tumor necrosis factor (TNF) related protein (CTRP) super-family. CTRP3 is found to function as adipokines that display diverse biological activities in metabolic and cardiovascular diseases. Recent study demonstrated that CTRP3 was protective against pathological cardiac remodeling in mice. Nevertheless, the effect of CTRP3 on vascular remodeling remains undefined. Our present study aimed to explore the effects of adipokine CTRP3 on the activation of adventitial fibroblasts (AFs) induced by TGF-β1...
2014: International Journal of Clinical and Experimental Pathology
Daisuke Yuasa, Koji Ohashi, Rei Shibata, Kyosuke Takeshita, Ryosuke Kikuchi, Ryotaro Takahashi, Yoshiyuki Kataoka, Megumi Miyabe, Yusuke Joki, Takahiro Kambara, Yusuke Uemura, Kazuhiro Matsuo, Satoko Hayakawa, Mizuho Hiramatsu-Ito, Masanori Ito, Nobuo Ikeda, Toyoaki Murohara, Noriyuki Ouchi
OBJECTIVE: Obesity is a major risk factor for cardiovascular disease. Recent evidence demonstrates that dysregulation of fat-derived hormones, also known as adipokines, is linked with the pathogenesis of obesity-related disorders including coronary artery disease (CAD). Here, we investigated whether circulating level of an adipokine C1q/TNF-related protein (CTRP) 1 is associated with the prevalence of CAD. METHODS AND RESULTS: Consecutive 76 male CAD patients were enrolled from inpatients that underwent coronary angiography...
2014: PloS One
Xuebo Pan, Tingting Lu, Fan Wu, Leigang Jin, Yi Zhang, Lihua Shi, Xiaokun Li, Zhuofeng Lin
BACKGROUND: Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP superfamily, possesses anti-inflammatory and anti-diabetic effects in mice. However, the clinical relevance of CTRP1 has been seldom explored. The current study aimed to investigate the association of circulating CTRP1 and type 2 diabetes mellitus (T2DM) in a Chinese population. DESIGN AND METHODS: Serum CTRP1 and adiponectin levels of 96 T2DM patients and 85 healthy subjects were determined by ELISA, and their associations with adiposity, glucose and lipid profiles were studied...
2014: PloS One
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