Read by QxMD icon Read

Sick sinus

Tetsuo Yamaguchi, Takamichi Miyamoto, Takamasa Iwai, Junji Yamaguchi, Sadahiro Hijikata, Ryoichi Miyazaki, Naoyuki Miwa, Masahiro Sekigawa, Nobuhiro Hara, Yasutoshi Nagata, Toshihiro Nozato, Yasuteru Yamauchi, Toru Obayashi, Mitsuaki Isobe
BACKGROUND: The prognosis of super-elderly patients (age≥85 years) who undergo bradycardia pacemaker (PM) implantation remains unknown. METHODS: We retrospectively enrolled 868 patients (men 49.0%, 76.6±10.6 years) who could walk unassisted and whose expected life expectancy was more than 1 year, receiving their first bradycardia PM implantation between January 1, 2006, and June 30, 2013. Clinical outcomes were compared between super-elderly patients (n=201, mean age 88...
October 15, 2016: Journal of Cardiology
Joachim Alexandre, Xavier Humbert, Marion Sassier, Paul Milliez, Antoine Coquerel, Sophie Fedrizzi
Cluster headache (CH) is a primary headache disorder with relatively effective treatments. Although few sufficiently controlled trials are available, verapamil is recommended as the first-line prophylactic drug for CH by the French Headache Society (with a low level of evidence, level B) and by the EFNS (European Federation of Neurological Societies, level A). Daily doses of more than 480 mg (and up to 1200 mg daily) are frequently used off-label, while 360 mg daily is the only dosage to have demonstrated its effectiveness in a double-blind trial against placebo, and the usual label posology used by cardiologists is 240 mg daily in hypertension...
December 2015: Drug Saf Case Rep
Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gisli Masson, Asmundur Oddsson, Olafur Th Magnusson, Jona Saemundsdottir, Hafdis Th Helgadottir, Hannes Helgason, Hrefna Johannsdottir, Solveig Gretarsdottir, Sigurjon A Gudjonsson, Inger Njølstad, Maja-Lisa Løchen, Larry Baum, Ronald C W Ma, Gunnlaugur Sigfusson, Augustine Kong, Guðmundur Thorgeirsson, Jon Th Sverrisson, Unnur Thorsteinsdottir, Kari Stefansson, David O Arnar
AIMS: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in man, causing substantial morbidity and mortality with a major worldwide public health impact. It is increasingly recognized as a highly heritable condition. This study aimed to determine genetic risk factors for early-onset AF. METHODS AND RESULTS: We sequenced the whole genomes of 8453 Icelanders and imputed genotypes of the 25.5 million sequence variants we discovered into 1799 Icelanders with early-onset AF (diagnosed before 60 years of age) and 337 453 controls...
October 14, 2016: European Heart Journal
Anni Koskinen, Petri Mattila, Jyri Myller, Matti Penttilä, Juha Silvola, Ismo Alastalo, Heini Huhtala, Maija Hytönen, Sanna Toppila-Salmi
CONCLUSION: In terms of operation time, anesthesia method, and low complication rate, ESS and balloon sinuplasty seemed comparable. The advantages of balloon sinuplasty were shown to be shortness of sick leave, possibility to be performed as an in-office procedure, and lower adhesion formation. BACKGROUND: Endoscopic sinus surgery (ESS) has been considered as a treatment of choice for persistent chronic rhinosinusitis (CRS). During the last decade balloon sinuplasty has been introduced as an alternative technique to dilate the ostium...
September 20, 2016: Acta Oto-laryngologica
Xiongfei Liang, Yifeng Yang
The clinical data for a patient with sick sinus syndrome was retrospectively analyzed. The patient was treated because of his heart palpitations and the increased chest pain. The patient admitted to the hospital under consideration for the left atrial tumor dependent on the echocardiography findings. After the CT scan and the dynamic ECG examination, the patient successfully underwent the left atrial tumor resection, atrial septal repair and cardiac pacing lead installation. The postoperative pathological diagnosis showed that the infective endocarditis and left atrial thrombus in left atrium was cured...
September 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
M Liu, K-C Yang, S C Dudley
The cardiac Na(+) channel (Nav1.5) conducts a depolarizing inward Na(+) current that is responsible for the generation of the upstroke Phase 0 of the action potential. In heart tissue, changes in Na(+) currents can affect conduction velocity and impulse propagation. The cardiac Nav1.5 is also involved in determination of the action potential duration, since some channels may reopen during the plateau phase, generating a persistent or late inward current. Mutations of cardiac Nav1.5 can induce gain or loss of channel function because of an increased late current or a decrease of peak current, respectively...
2016: Current Topics in Membranes
David O Arnar, Karl Andersen, Gudmundur Thorgeirsson
In the past ten years large scale genotyping has led to discoveries of sequence variants that confer risk of many common and complex diseases. Due to pioneering work done, in large part, at deCODE genetics in Reykjavik, discoveries from Iceland have contributed substantially to key advances in population genetics. In cardiovascular medicine a number of discoveries have been made, uncovering sequence variants that are associated with disorders such as coronary artery disease, atrial fibrillation, sick sinus syndrome, peripheral vascular disease, aortic aneurysm and ischemic stroke...
August 30, 2016: Scandinavian Cardiovascular Journal: SCJ
Yanhui Li, Mathew D Olson, Jian-Ming Li
A 79-year-old man received a dual-chamber pacemaker (Evia DR-T, Biotronik GmbH, Berlin, Germany) for syncope and sick sinus syndrome with paroxysmal atrial fibrillation. His past medical history included systemic hypertension, hyperlipidemia, coronary artery disease, diabetes mellitus type II, obstructive sleep apnea, diffuse lung disease, diastolic congestive heart failure with preserved systolic function. This article is protected by copyright. All rights reserved.
August 24, 2016: Pacing and Clinical Electrophysiology: PACE
Stephanie Biel, Marco Aquila, Brigitte Hertel, Anne Berthold, Thomas Neumann, Dario DiFrancesco, Anna Moroni, Gerhard Thiel, Silke Kauferstein
Diseases such as the sick sinus and the Brugada syndrome are cardiac abnormalities, which can be caused by a number of genetic aberrances. Among them are mutations in HCN4, a gene, which encodes the hyperpolarization-activated, cyclic nucleotide-gated ion channel 4; this pacemaker channel is responsible for the spontaneous activity of the sinoatrial node. The present genetic screening of patients with suspected or diagnosed Brugada or sick sinus syndrome identified in 1 out of 62 samples the novel mutation V492F...
October 2016: Pflügers Archiv: European Journal of Physiology
Jou-Kou Wang, Shuenn-Nan Chiu, Ming-Tai Lin, Chun-An Chen, Chun-Wei Lu, Mei-Hwan Wu
We investigated the mid-to-long-term results of transcatheter closure of atrial septal defect (ASD) in patients ≥40 years since there are issues with patients presenting with pulmonary hypertension and arrhythmia at the time of closure. In an 8.8 year period, transcatheter closure of ASD was successful in 179 patients aged ≥40 years, but failed in 2. Of the 179 patients (44 males, median 53 years), NYHA functional class, presence of arrhythmia and severity of pulmonary hypertension were compared before and after closure...
August 16, 2016: Heart and Vessels
Alexander Kypta, Hermann Blessberger, Michael Lichtenauer, Thomas Lambert, Juergen Kammler, Clemens Steinwender
A 65-year-old man was scheduled for pacemaker implantation for symptomatic sick-sinus-syndrome (SSS). He suffered from multiple drug-allergies and allergies to several metals like quicksilver and titanium. Gold-coated pacemaker generators and polyurethane leads are effective in avoiding allergic reactions to pacing system components. Therefore, we decided to implant a custom-made gold-coated DDDR-pacemaker generator and polyurethane leads.
November 2015: Indian Pacing and Electrophysiology Journal
Jan-Yow Chen, Jiung-Hsiun Liu, Hong-Dar Isaac Wu, Kuo-Hung Lin, Kuan-Cheng Chang, Ying-Ming Liou
BACKGROUND: Familial sick sinus syndrome is associated with gene mutations and dysfunction of ion channels. In contrast, degenerative fibrosis of the sinus node tissue plays an important role in the pathogenesis of acquired sick sinus syndrome. There is a close relationship between transforming growth factor-β1 mediated cardiac fibrosis and acquired arrhythmia. It is of interest to examine whether transforming growth factor-β1 is involved in the pathogenesis of acquired sick sinus syndrome...
2016: PloS One
Pietro Mesirca, Isabelle Bidaud, Matteo E Mangoni
Pacemaker activity of the sino-atrial generates the heart rate. Disease of the sinus node and impairment of atrioventricular conduction induce an excessively low ventricular rate (bradycardia), which cannot meet the needs of the organism. Bradycardia accounts for about half of the total workload of clinical cardiologists. The "sick sinus" syndrome (SSS) is characterized by sinus bradycardia and periods of intermittent atrial fibrillation. Several genetic or acquired risk factors or pathologies can lead to SSS...
July 4, 2016: Journal of Physiology
Shanmuga Sundaram Rathakrishnan, Tamilarasu Kaliappan, Rajendiran Gopalan
We report two young patients with symptomatic sick sinus syndrome admitted for permanent pacemaker implantation (PPI). On evaluation with echocardiography, one of them was found to have persistent left superior vena cava and venography showed absent right superior vena cava also. He underwent PPI with leads inserted via left superior vena cava, coronary sinus, right atrium and right ventricle. The other patient was incidentally found to have interrupted inferior vena cava with azygos continuation while being planned for temporary pacemaker implantation...
July 2015: Heart Views: the Official Journal of the Gulf Heart Association
Takuya Maeda, Takahiko Sakamoto, Mitsugi Nagashima, Takeshi Hiramatsu, Kenji Yamazaki
BACKGROUND: We evaluated long-term outcomes of the arterial switch operation (ASO) conversion after a failed Senning/Mustard operation among patients with dextro-transposition of the great arteries. METHODS: Between 1986 and 2006, 9 patients with dextro-transposition of the great arteries underwent ASO conversion at our institute. All patients had systemic right ventricle failure, 6 had supraventricular tachycardia, and 8 had moderate or severe tricuspid valve regurgitation...
June 1, 2016: Annals of Thoracic Surgery
Germán Fernández, Gustavo Fabián Maid, Aníbal Martín Arias, Sebastián Maldonado, Rodolfo Pizarro, Cesar Antonio Belziti
OBJECTIVES: To assess the prevalence of atrial fibrillation (AF) in patients with dual-chamber pacemakers (DP), determine the variables associated with development of AF and evaluate the changes in AF's management by physicians. METHODS: Five hundred patients with DP were prospectively included and interrogated. When AF was detected physicians in charge of the patient were warned. Changes in AF's management were evaluated. RESULTS: Mean age of the study population was 77 years, with 51% of men...
July 2016: Archivos de Cardiología de México
Michael V Zaragoza, Lianna Fung, Ember Jensen, Frances Oh, Katherine Cung, Linda A McCarthy, Christine K Tran, Van Hoang, Simin A Hakim, Anna Grosberg
The goals are to understand the primary genetic mechanisms that cause Sick Sinus Syndrome and to identify potential modifiers that may result in intrafamilial variability within a multigenerational family. The proband is a 63-year-old male with a family history of individuals (>10) with sinus node dysfunction, ventricular arrhythmia, cardiomyopathy, heart failure, and sudden death. We used exome sequencing of a single individual to identify a novel LMNA mutation and demonstrated the importance of Sanger validation and family studies when evaluating candidates...
2016: PloS One
Irina Crăcană, T F Vasilcu, Alexandra Mardare, Ioana Dana Alexa, D T M Marcu
Sinus node dysfunction is one of the most common arrhythmias in elderly patients; it is usually associated with intermittent and variable symptoms, thus making it difficult to diagnose. We present the case of an elderly female patient with a personal history of atrial fibrillation treated for the last three years with amiodarone; she was admitted to the Geriatric Clinic for non-specific symptoms with onset two months previously for which she had already sought care in different medical services. Clinical examination showed severe bradycardia; ECG and Holter ECG on admission confirmed severe bradycardia, with a heart rate between 29 and 50 beats/min (bpm)...
January 2016: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Jinfeng Liu, Ruxiu Liu, Jie Peng, Yanli Wang
The hyperpolarization-activated cyclic nucleotide-gated cation channel (I f ) is closely associated with sinoatrial node pacing function. The present study aimed to investigate the molecular mechanisms involved in pacing function improvements of damaged sinoatrial node cells and the consequent treatment effects on sick sinus syndrome (SSS) after the use of Yiqi Tongyang. HCN4 channel protein expression and phosphorylation were measured by immunoblotting and fluorescent quantitation. After ischemia-reperfusion injury (model group), the HCN4 protein and the optical density (OD) of the phosphorylated HCN4 protein as well as intracellular PKA activity in the sinoatrial node cells decreased significantly...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
Tal Levinson, Tamar Sela, Shmuel Chencinski, Estela Derazne, Dorit Tzur, Hadar Elad, Yitshak Kreiss
OBJECTIVES: To identify military occupational risk factors for pilonidal sinus disease (PSD) and to compare an Army Clinic minimal surgery with techniques used at public hospitals. METHODS: Review of a historical cohort of soldiers (3,407 with PSD) to determine PSD risk factors in military personnel and comparison of postoperative sick leave days between surgical techniques. RESULTS: Male and female officers had a lower PSD incidence, whereas male combatants and female drivers were at higher risk compared to administrative personnel...
April 2016: Military Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"