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https://www.readbyqxmd.com/read/28214798/intensive-blood-pressure-lowering-in-patients-with-acute-intracerebral-haemorrhage-clinical-outcomes-and-haemorrhage-expansion-systematic-review-and-meta-analysis-of-randomised-trials
#1
Gregoire Boulouis, Andrea Morotti, Joshua N Goldstein, Andreas Charidimou
INTRODUCTION: It is unclear whether intensive lowering of blood pressure (BP) at the acute phase of intracerebral haemorrhage (ICH) is beneficial. We performed a meta-analysis of randomised controlled trials (RCTs) to assess whether intensive BP lowering in patients with acute ICH is safe and effective in improving clinical outcomes. METHODS: We searched PubMed, EMBASE and the Cochrane databases for relevant RCTs and calculated pooled OR for 3-month mortality (safety outcome) and 3-month death or dependency (modified Rankin Scale (mRs) ≥3;efficacy outcome), in patients with acute ICH randomised to either intensive BP-lowering or standard BP-lowering treatment protocols...
February 18, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28214538/contemporary-animal-models-of-cardiac-arrest-a-systematic-review
#2
REVIEW
Mikael Vognsen, Bjørn K Fabian-Jessing, Niels Secher, Bo Løfgren, Cameron Dezfulian, Lars W Andersen, Asger Granfeldt
AIM OF THE STUDY: Animal models are widely used in cardiac arrest research. This systematic review aimed to provide an overview of contemporary animal models of cardiac arrest. METHODS: Using a comprehensive research strategy, we searched PubMed and EMBASE from March 8, 2011 to March 8, 2016 for cardiac arrest animal models. Two investigators reviewed titles and abstracts for full text inclusions from which data were extracted according to pre-defined definitions...
February 15, 2017: Resuscitation
https://www.readbyqxmd.com/read/28214351/evidence-based-and-precision-medicine-two-of-a-kind
#3
W J Fokkens
In the last two decades, an enormous expansion of evidence has been produced in upper airway research. When writing the first EPOS document in 2005 only 5 RCT per year were performed in the area of CRS, in 2007 this changed to 25 per year and it became even higher in the recent years. Randomized Controlled Trials (RCTs) are the "gold standard" for evaluating treatment outcomes providing information on treatments "efficacy". To make life easier for clinicians, systematic reviews and meta-analysis further condense the available evidence...
February 18, 2017: Rhinology
https://www.readbyqxmd.com/read/28213859/recurrence-in-localized-renal-cell-carcinoma-a-systematic-review-of-contemporary-data
#4
REVIEW
Jacqueline M Speed, Quoc-Dien Trinh, Toni K Choueiri, Maxine Sun
PURPOSE OF REVIEW: Patients with localized renal cell carcinoma (RCC) are at risk of recurrence. The purpose of this review was to characterize the literature on recurrence rates and risk factors after diagnosis of localized RCC. RECENT FINDINGS: Our search revealed that existing data examining the prevalence of recurrence rates predominantly originates from cohorts of patients diagnosed and treated in the 1980s to 1990s, and may therefore not be as useful for counseling for current patients today...
February 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28213755/pedagogical-approaches-to-and-effects-of-fundamental-movement-skill-interventions-on-health-outcomes-a-systematic-review
#5
REVIEW
Claire Tompsett, Ross Sanders, Caitlin Taylor, Stephen Cobley
BACKGROUND: Fundamental movement skills (FMS) are assumed to be the basic prerequisite motor movements underpinning coordination of more integrated and advanced movement capabilities. FMS development and interventions have been associated with several beneficial health outcomes in individual studies. OBJECTIVE: The primary aim of this review was to identify FMS intervention characteristics that could be optimised to attain beneficial outcomes in children and adolescents, while the secondary aim was to update the evidence as to the efficacy of FMS interventions on physiological, psychological and behavioural health outcomes...
February 18, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28212957/a-systematic-review-of-health-economics-simulation-models-of-chronic-obstructive-pulmonary-disease
#6
REVIEW
Zafar Zafari, Stirling Bryan, Don D Sin, Tania Conte, Rahman Khakban, Mohsen Sadatsafavi
BACKGROUND: Many decision-analytic models with varying structures have been developed to inform resource allocation in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To review COPD models for their adherence to the best practice modeling recommendations and their assumptions regarding important aspects of the natural history of COPD. METHODS: A systematic search of English articles reporting on the development or application of a decision-analytic model in COPD was performed in MEDLINE, Embase, and citations within reviewed articles...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212691/efficacy-of-the-new-generation-of-devices-for-positional-therapy-for-patients-with-positional-obstructive-sleep-apnea-a-systematic-review-of-the-literature-and-meta-analysis
#7
Madeline J L Ravesloot, David White, Raphael Heinzer, Arie Oksenberg, Jean-Louis Pépin
STUDY OBJECTIVES: In approximately 56% to 75% of patients with obstructive sleep apnea (OSA), the frequency and duration of apneas are influenced by body position. This is referred to as position-dependent OSA or POSA. Patients with POSA can be treated with a small device attached to either the neck or chest. These devices-a new generation of devices for positional therapy (PT)-provide a subtle vibrating stimulus that prevents patients adopting the supine position. The objectives of this study were to determine whether PT is effective in improving sleep study variables and sleepiness, and to assess compliance...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28212414/decline-in-infection-related-morbidities-following-drug-mediated-reductions-in-the-intensity-of-schistosoma-infection-a-systematic-review-and-meta-analysis
#8
Gisele Andrade, David J Bertsch, Andrea Gazzinelli, Charles H King
BACKGROUND: Since 1984, WHO has endorsed drug treatment to reduce Schistosoma infection and its consequent morbidity. Cross-sectional studies suggest pre-treatment correlation between infection intensity and risk for Schistosoma-related pathology. However, evidence also suggests that post-treatment reduction in intensity may not reverse morbidity because some morbidities occur at all levels of infection, and some reflect permanent tissue damage. The aim of this project was to systematically review evidence on drug-based control of schistosomiasis and to develop a quantitative estimate of the impact of post-treatment reductions in infection intensity on prevalence of infection-associated morbidity...
February 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28210547/nipple-areolar-complex-reconstruction-and-patient-satisfaction-a-systematic-review-and-meta-analysis
#9
Ellen S Satteson, Benjamin J Brown, Maurice Y Nahabedian
BACKGROUND: Nipple-areola complex (NAC) reconstruction transforms a mound of soft tissue into a breast and often marks the final stage of breast reconstruction after mastectomy. METHODS: A systematic review and meta-analysis were conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. Articles were classified based on the nipple reconstructive technique-either composite nipple sharing or local flap with nipple-sparing mastectomy (NSM) used as a control...
February 2017: Gland Surgery
https://www.readbyqxmd.com/read/28209944/impact-of-contact-force-technology-on-reducing-the-recurrence-and-major-complications-of-atrial-fibrillation-ablation-a-systematic-review-and-meta-analysis
#10
Xianhui Zhou, Wenkui Lv, Wenhui Zhang, Yuanzheng Ye, Yaodong Li, Qina Zhou, Qiang Xing, Jianghua Zhang, Yanmei Lu, Ling Zhang, Hongli Wang, Wen Qin, Baopeng Tang
Contact force (CF) monitoring can be useful in accomplishing circumferential pulmonary vein (PV) isolation for atrial fibrillation (AF). This meta-analysis aimed to assess the efficacy and safety of a CF-sensing catheter in treating AF. Randomized controlled trials or non-randomized observational studies comparing AF ablation using CF-sensing or standard non-CF (NCF)-sensing catheters were identified from PubMed, EMBASE, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure (January 1, 1998-2016)...
February 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28209192/learning-from-2523-trauma-deaths-in-india-opportunities-to-prevent-in-hospital-deaths
#11
Nobhojit Roy, Deepa Kizhakke Veetil, Monty Uttam Khajanchi, Vineet Kumar, Harris Solomon, Jyoti Kamble, Debojit Basak, Göran Tomson, Johan von Schreeb
BACKGROUND: A systematic analysis of trauma deaths is a step towards trauma quality improvement in Indian hospitals. This study estimates the magnitude of preventable trauma deaths in five Indian hospitals, and uses a peer-review process to identify opportunities for improvement (OFI) in trauma care delivery. METHODS: All trauma deaths that occurred within 30 days of hospitalization in five urban university hospitals in India were retrospectively abstracted for demography, mechanism of injury, transfer status, injury description by clinical, investigation and operative findings...
February 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28207928/industry-sponsorship-and-research-outcome
#12
REVIEW
Andreas Lundh, Joel Lexchin, Barbara Mintzes, Jeppe B Schroll, Lisa Bero
BACKGROUND: Clinical research affecting how doctors practice medicine is increasingly sponsored by companies that make drugs and medical devices. Previous systematic reviews have found that pharmaceutical-industry sponsored studies are more often favorable to the sponsor's product compared with studies with other sources of sponsorship. A similar association between sponsorship and outcomes have been found for device studies, but the body of evidence is not as strong as for sponsorship of drug studies...
February 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28207917/the-role-of-ect-in-posttraumatic-stress-disorder-a-systematic-review
#13
Nagy A Youssef, W Vaughn McCall, Chittaranjan Andrade
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with a high burden of disability and mortality and frequently is treatment resistant. There is little to offer patients who are not responding to standard interventions. Thus, the objective of this report is to systematically review human data on whether electroconvulsive therapy (ECT) is effective in PTSD. METHODS: We performed a systematic literature review from 1958 through August 2016 for clinical studies and case reports published in English examining the efficacy of ECT in improving PTSD symptoms...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28207839/plasma-fibrin-d-dimer-and-the-risk-of-left-atrial-thrombus-a-systematic-review-and-meta-analysis
#14
Huaibin Wan, Shuang Wu, Yanmin Yang, Jun Zhu, Aidong Zhang, Yan Liang
BACKGROUND: Plasma fibrin d-dimer has been taken as a marker for thrombus. The aim of this study was to evaluate the relationship between d-dimer (DD) levels and left atrial spontaneous echo contrast (SEC)/left atrial thrombus (LAT). METHODS: We identified clinical studies by systematic search of MEDLINE and EMBASE databases up to Feb 2016. All observational studies that considered DD as a study factor and trans-esophageal echocardiography (TEE) identified SEC/LAT as an outcome were included...
2017: PloS One
https://www.readbyqxmd.com/read/28207516/economic-evaluation-of-mobile-phone-text-message-interventions-to-improve-adherence-to-hiv-therapy-in-kenya
#15
Anik R Patel, Jason Kessler, R Scott Braithwaite, Kimberly A Nucifora, Harsha Thirumurthy, Qinlian Zhou, Richard T Lester, Carlo A Marra
BACKGROUND: A surge in mobile phone availability has fueled low cost short messaging service (SMS) adherence interventions. Multiple systematic reviews have concluded that some SMS-based interventions are effective at improving antiretroviral therapy (ART) adherence, and they are hypothesized to improve retention in care. The objective of this study was to evaluate the cost-effectiveness of SMS-based adherence interventions and explore the added value of retention benefits. METHODS: We evaluated the cost-effectiveness of weekly SMS interventions compared to standard care among HIV+ individuals initiating ART for the first time in Kenya...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205414/avoidance-of-maternal-cell-contamination-and-overgrowth-in-isolating-fetal-chorionic-villi-mesenchymal-stem-cells-from-human-term-placenta
#16
Varda S Sardesai, Abbas Shafiee, Nicholas M Fisk, Rebecca A Pelekanos
Human placenta is rich in mesenchymal stem/stromal cells (MSC), with their origin widely presumed fetal. Cultured placental MSCs are confounded by a high frequency of maternal cell contamination. Our recent systematic review concluded that only a small minority of placental MSC publications report fetal/maternal origin, and failed to discern a specific methodology for isolation of fetal MSC from term villi. We determined isolation conditions to yield fetal and separately maternal MSC during ex vivo expansion from human term placenta...
February 16, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28204997/predicting-surgical-outcome-in-patients-with-glioblastoma-multiforme-using-pre-operative-magnetic-resonance-imaging-development-and-preliminary-validation-of-a-grading-system
#17
Hani J Marcus, Sophie Williams, Archie Hughes-Hallett, Sophie J Camp, Dipankar Nandi, Lewis Thorne
The lack of a simple, objective and reproducible system to describe glioblastoma multiforme (GBM) represents a major limitation in comparative effectiveness research. The objectives of this study were therefore to develop such a grading system and to validate it on patients who underwent surgical resection. A systematic review of the literature was performed to identify features on pre-operative magnetic resonance imaging (MRI) that predict the surgical outcome of patients with GBM. In all, the five most important features of GBM on pre-operative MRI were as follows: periventricular or deep location, corpus callosum or bilateral location, eloquent location, size and associated oedema...
February 15, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28204730/the-effectiveness-and-risks-of-fluoroscopically-guided-lumbar-interlaminar-epidural-steroid-injections-a-systematic-review-with-comprehensive-analysis-of-the-published-data
#18
Anil K Sharma, Yakov Vorobeychik, Ronald Wasserman, Jessica Jameson, Maxim Moradian, Belinda Duszynski, David J Kennedy
No abstract text is available yet for this article.
February 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28203326/the-needs-of-parents-of-preterm-infants-in-iran-and-a-comparison-with-those-in-other-countries-a-systematic-review-and-meta-analysis
#19
REVIEW
Seyedeh Saeedeh Mousavi, Reza Chaman, Ahmad Khosravi, Parisa Mohagheghi, Seyed Abbas Mousavi, Afsaneh Keramat
CONTEXT: Proper accountability to needs of preterm infants' parents requires recognition of these needs and how they change in different conditions. The aim of this study was to assess the needs of parents of preterm infants in Iran, as compared to those in other regions in the world. EVIDENCE ACQUISITION: A search of Iranian databases (Iran Medex, Magiran, and SID) and international resources (PubMed, Scopus, and Google Scholar) was conducted, with no time limitations, to 5 October 2014...
October 2016: Iranian Journal of Pediatrics
https://www.readbyqxmd.com/read/28202945/left-ventricular-hypertrophy-in-association-with-cognitive-impairment-a-systematic-review-and-meta-analysis
#20
Marios K Georgakis, Andreas Synetos, Constantinos Mihas, Maria A Karalexi, Dimitrios Tousoulis, Sudha Seshadri, Eleni Th Petridou
Left ventricular hypertrophy (LVH) is a marker of prolonged exposure to high blood pressure and a predictor of cardiovascular disease risk. The objective of the current study was to investigate its association with cognitive function. Following standard guidelines, pairs of independent reviewers screened 2359 articles to search for studies that addressed the research question, extracted data and evaluated the quality of the studies using the Newcastle-Ottawa scale; authors were contacted for additional data...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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