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Atrial electrical remodeling

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https://www.readbyqxmd.com/read/27917818/galectin-3-a-biochemical-marker-to-detect-paroxysmal-atrial-fibrillation
#1
Yusuf Selcoki, H İbrahim Aydin, Tugrul H Celik, Ahmet Isleyen, Ali Erayman, M Bora Demircelik, Hilmi Demirin, Aydin Kosus, Beyhan Eryonucu
PURPOSE: Atrial fibrillation (AF) is the most common form of arrhythmia. AF leads to electrical remodelling and fibrosis of the atria; however, the mechanism(s) remain poorly understood. Galectin-3 is a potential mediator of cardiac fibrosis. The present study aimed to examine the relationship between serum galectin-3 levels and paroxysmal AF. METHODS: Forty-six patients with paroxysmal AF and preserved left ventricular systolic function, and 38 age- and gender-matched control subjects, were involved in the study...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27907144/a-new-efficient-method-for-detecting-phase-singularity-in-cardiac-fibrillation
#2
Young-Seon Lee, Jun-Seop Song, Minki Hwang, Byounghyun Lim, Boyoung Joung, Hui-Nam Pak
BACKGROUND: The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. METHODS: In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2π (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs...
2016: PloS One
https://www.readbyqxmd.com/read/27905214/the-association-of-plasma-oxidative-status-and-inflammation-with-the-development-of-atrial-fibrillation-in-patients-presenting-with-st-elevation-myocardial-infarction
#3
Hasan Aydin Bas, Fatih Aksoy, Atilla Icli, Ercan Varol, Abdullah Dogan, Dogan Erdogan, Ibrahim Ersoy, Akif Arslan, Hatem Ari, Nihal Bas, Recep Sutcu, Mehmet Ozaydin
Atrial fibrillation (AF) is the most common supraventricular arrhythmia following ST elevation myocardial infarction (STEMI). Oxidative stress and inflammation may cause structural and electrical remodeling in the atria making these critical processes in the pathology of AF. In this study, we aimed to evaluate the association between total oxidative status (TOS), total antioxidative capacity (TAC) and high-sensitivity C-reactive protein (hs-CRP) in the development of AF in patients presenting with STEMI. This prospective cohort study consisted of 346 patients with STEMI...
December 1, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27862036/association-of%C3%AE-1-adrenergic%C3%A3-m2-muscarinic-receptor-autoantibody-with-occurrence-and-development-of-nonvalvular-atrial-fibrillation
#4
Bing Hu, Yanxiang Sun, Sha Li, Jie Sun, Tong Liu, Zidi Wu, L I Feng
BACKGROUND: Atrial fibrillation (AF) is the most common sustained arrhythmia and an independent increased risk of stroke and death. Although the exact mechanisms of AF are not completely elucidated, a large number of evidences demonstrate that autoimmunity may play an important role in the initiation, the progression and the maintenance of AF. In this study, we aimed to compare Anti-β1-Adrenergic Receptor Autoantibody (anti-β1 -R) and Anti- M2-Muscarinic Receptor Autoantibody(anti-M2 -R) levels between non-valvular AF patients and healthy control subjects...
November 10, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27826248/slow-conduction-in-the-border-zones-of-patchy-fibrosis-stabilizes-the-drivers-for-atrial-fibrillation-insights-from-multi-scale-human-atrial-modeling
#5
Ross Morgan, Michael A Colman, Henry Chubb, Gunnar Seemann, Oleg V Aslanidi
Introduction: The genesis of atrial fibrillation (AF) and success of AF ablation therapy have been strongly linked with atrial fibrosis. Increasing evidence suggests that patient-specific distributions of fibrosis may determine the locations of electrical drivers (rotors) sustaining AF, but the underlying mechanisms are incompletely understood. This study aims to elucidate a missing mechanistic link between patient-specific fibrosis distributions and AF drivers. Methods: 3D atrial models integrated human atrial geometry, rule-based fiber orientation, region-specific electrophysiology, and AF-induced ionic remodeling...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27812293/atrial-electrophysiological-remodeling-and-fibrillation-in-heart-failure
#6
REVIEW
Sandeep V Pandit, Antony J Workman
Heart failure (HF) causes complex, chronic changes in atrial structure and function, which can cause substantial electrophysiological remodeling and predispose the individual to atrial fibrillation (AF). Pharmacological treatments for preventing AF in patients with HF are limited. Improved understanding of the atrial electrical and ionic/molecular mechanisms that promote AF in these patients could lead to the identification of novel therapeutic targets. Animal models of HF have identified numerous changes in atrial ion currents, intracellular calcium handling, action potential waveform and conduction, as well as expression and signaling of associated proteins...
2016: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/27812021/mechanisms-of-arrhythmogenesis-related-to-calcium-driven-alternans-in-a-model-of-human-atrial-fibrillation
#7
Kelly C Chang, Natalia A Trayanova
The occurrence of atrial fibrillation (AF) is associated with progressive changes in the calcium handling system of atrial myocytes. Calcium cycling instability has been implicated as an underlying mechanism of electrical alternans observed in patients who experience AF. However, the extent to which calcium-induced alternation of electrical activity in the atria contributes to arrhythmogenesis is unknown. In this study, we investigated the effects of calcium-driven alternans (CDA) on arrhythmia susceptibility in a biophysically detailed, 3D computer model of the human atria representing electrical and structural remodeling secondary to chronic AF...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27693594/obstructive-sleep-apnea-and-cardiac-arrhythmogenesis-mechanistic-insights
#8
Anna M May, David R Van Wagoner, Reena Mehra
A surge of data has reproducibly identified strong associations of obstructive sleep apnea (OSA) with cardiac arrhythmias. As an extension of epidemiologic and clinic-based findings, experimental investigations have made strides in advancing our understanding of the putative OSA and cardiac arrhythmogenesis mechanistic underpinnings. While most studies have focused on the links between OSA and atrial fibrillation (AF), relationships with ventricular arrhythmias have also been characterized. Key findings implicate OSA-related autonomic nervous system fluctuations typified by enhanced parasympathetic activation during and sympathetic surges subsequent to respiratory events which contribute to augmented arrhythmic propensity...
September 29, 2016: Chest
https://www.readbyqxmd.com/read/27660282/cross-talk-between-macrophages-and-atrial-myocytes-in-atrial-fibrillation
#9
Zewei Sun, Dongchen Zhou, Xudong Xie, Shuai Wang, Zhen Wang, Wenting Zhao, Hongfei Xu, Liangrong Zheng
Increased macrophage accumulation occurs in the atria of patients with atrial fibrillation (AF). However, the phenotype and functions of the macrophages in AF remain unclear. We investigated the macrophage-atrial myocyte interaction in AF patients and found that the increased macrophages were mainly pro-inflammatory macrophages (iNOS(+), Arg1(-)). Tachypacing of HL-1 atrial myocytes also led to pro-inflammatory macrophage polarization. In addition, lipopolysaccharide (LPS)-stimulated pro-inflammatory macrophages-induced atrial electrical remodeling, evidenced by increased AF incidence and decreased atrial effective refractory period and L-type calcium currents (I Ca-L) in both canine and mouse AF models...
November 2016: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27658928/investigation-of-the-atrial-conduction-time-measured-by-tissue-doppler-imaging-at-the-left-atrial-appendage-and-the-actual-electrical-conduction-time-consideration-of-left-atrial-remodeling-in-atrial-fibrillation-patients
#10
Yuichi Hori, Shiro Nakahara, Naofumi Anjo, Ayako Nakagawa, Naoki Nishiyama, Kouta Yamada, Akiko Hayashi, Takaaki Komatsu, Sayuki Kobayashi, Yoshihiko Sakai, Isao Taguchi
PURPOSE: The atrial conduction time measured by echocardiography using tissue Doppler imaging (TDI) has been reported as a predictive factor of left atrial (LA) remodeling. We investigated the P wave to LA appendage (LAA) conduction time defined by transthoracic echocardiography using TDI (P-LAA TDI), and directly compared the actual LA electrical conduction time determined by the electrophysiological data. Additionally, we confirmed the clinical utility of the P-LAA TDI by examining the relationship to the electroanatomical LA remodeling data...
September 22, 2016: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/27600472/nkx2-5-carp-signaling-pathway-contributes-to-the-regulation-of-ion-channel-remodeling-induced-by-rapid-pacing-in-rat-atrial-myocytes
#11
Wei Wang, Yun Zhu, Jianguang Yi, Wei Cheng
Remodeling of atrial electrophysiology and structure is the primary feature of atrial fibrillation (AF). Evidence suggests that abnormalities in the expression levels of embryological cardiovascular development‑associated transcription factors, including Nkx2.5, are crucial for the development of AF. Rat atrial myocardial cells (AMCs) in culture dishes were placed in an electric field and stimulated. Transmission electron microscopy was used to observe the ultrastucture prior to and following rapid pacing...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27568995/the-sympathetic-innervation-of-the-heart-important-new-insights
#12
REVIEW
J H Coote, R A Chauhan
Autonomic control of the heart has a significant influence over development of life threatening arrhythmias that can lead to sudden cardiac death. Sympathetic activity is known to be upregulated during these conditions and hence the sympathetic nerves present a target for treatment. However, a better understanding of the anatomy and physiology of cardiac sympathetic nerves is required for the progression of clinical interventions. This review explores the organization of the cardiac sympathetic nerves, from the preganglionic origin to the postganglionic innervations, and provides an overview of literature surrounding anti-arrhythmic therapies including thoracic sympathectomy and dorsal spinal cord stimulation...
August 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27562817/protective-role-of-heme-oxygenase-1-in-atrial-remodeling
#13
Yung-Hsin Yeh, Lung-An Hsu, Ying-Hwa Chen, Chi-Tai Kuo, Gwo-Jyh Chang, Wei-Jan Chen
Structural and electrical remodeling in the atrium constitutes the main feature of atrial fibrillation (AF), which is characterized by increased oxidative stress. Heme oxygenase-1 (HO-1) is a potent anti-oxidant system that may provide protection against various oxidative stress-related diseases. The aim of this study is to investigate whether HO-1 has a protective effect on AF-related remodeling. Cultured atrium-derived myocytes (HL-1 cell line) were used to evaluate tachypacing-induced oxidative stress, structural, and electrical remodeling...
September 2016: Basic Research in Cardiology
https://www.readbyqxmd.com/read/27526304/association-of-atrial-fibrillation-with-morphological-and-electrophysiological-changes-of-the-atrial-myocardium
#14
Adéla Matějková, Ivo Šteiner
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. For long time it was considered as pure functional disorder, but in recent years, there were identified atrial locations, which are involved in the initiation and maintenance of this arrhythmia. These structural changes, so called remodelation, start at electric level and later they affect contractility and morphology. In this study we attempted to find a possible relation between morphological (scarring, amyloidosis, left atrial (LA) enlargement) and electrophysiological (ECG features) changes in patients with AF...
2016: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/27525318/galectin-3-regulates-atrial-fibrillation-remodeling-and-predicts-catheter-ablation-outcomes
#15
Yoshio Takemoto, Rafael J Ramirez, Miki Yokokawa, Kuljeet Kaur, Daniela Ponce-Balbuena, Mohamad C Sinno, B Cicero Willis, Hamid Ghanbari, Steven R Ennis, Guadalupe Guerrero-Serna, Bettina C Henzi, Rakesh Latchamsetty, Roberto Ramos-Mondragon, Hassan Musa, Raphael P Martins, Sandeep V Pandit, Sami F Noujaim, Thomas Crawford, Krit Jongnarangsin, Frank Pelosi, Frank Bogun, Aman Chugh, Omer Berenfeld, Fred Morady, Hakan Oral, José Jalife
OBJECTIVES: To determine whether Gal-3 mediates sustained atrial fibrillation (AF)-induced atrial structural and electrical remodeling and contributes to AF perpetuation. BACKGROUND: Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored. METHODS: We examined intracardiac blood samples from patients with AF (N=55) to identify potential biomarkers of AF recurrence. In a sheep model of tachypacing-induced AF (N=20), we tested the effects of Gal-3 inhibition during AF progression...
April 2016: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/27520541/low-level-carotid-baroreflex-stimulation-suppresses-atrial-fibrillation-by-inhibiting-left-stellate-ganglion-activity-in-acute-canine-model
#16
Mingyan Dai, Mingwei Bao, Yijie Zhang, Lilei Yu, Quan Cao, Yanhong Tang, He Huang, Xi Wang, Dan Hu, Congxin Huang
BACKGROUND: Low-level carotid baroreflex stimulation (LL-CBS) appears to have potential antiarrhythmogenic effect. OBJECTIVES: To investigate effects of short term LL-CBS on atrial fibrillation (AF) canine model. METHODS: Group 1: anesthetized dogs underwent 6 h of rapid atrial pacing (RAP) with concomitant LL-CBS in last three hours (LL-CBS group, n=7) or without (Control group, n=6). Effective refractory period (ERP), ERP dispersion, and window of vulnerability (WOV) to AF were determined...
August 9, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27488468/oxidized-low-density-lipoprotein-ox-ldl-cholesterol-induces-the-expression-of-mirna-223-and-l-type-calcium-channel-protein-in-atrial-fibrillation
#17
Fengping He, Xin Xu, Shuguo Yuan, Liangqiu Tan, Lingjun Gao, Shaochun Ma, Shebin Zhang, Zhanzhong Ma, Wei Jiang, Fenglian Liu, Baofeng Chen, Beibei Zhang, Jungang Pang, Xiuyan Huang, Jiaqiang Weng
Atrial fibrillation (AF) is the most common sustained arrhythmia causing high morbidity and mortality. While changing of the cellular calcium homeostasis plays a critical role in AF, the L-type calcium channel α1c protein has suggested as an important regulator of reentrant spiral dynamics and is a major component of AF-related electrical remodeling. Our computational modeling predicted that miRNA-223 may regulate the CACNA1C gene which encodes the cardiac L-type calcium channel α1c subunit. We found that oxidized low-density lipoprotein (ox-LDL) cholesterol significantly up-regulates both the expression of miRNA-223 and L-type calcium channel protein...
August 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27485559/change-in-p-wave-morphology-after-convergent-atrial-fibrillation-ablation
#18
Suvash Shrestha, On Chen, Mary Greene, Jinu Jacob John, Yisachar Greenberg, Felix Yang
Convergent atrial fibrillation ablation involves extensive epicardial as well as endocardial ablation of the left atrium. We examined whether it changes the morphology of the surface P wave. We reviewed electrocardiograms of 29 patients who underwent convergent ablation for atrial fibrillation. In leads V1, II and III, we measured P wave duration, area and amplitude before ablation, and at 1, 3 and 6 months from ablation. After ablation, there were no significant changes in P wave amplitude, area, or duration in leads II and III...
January 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/27453277/norepinephrine-and-acetylcholine-changes-during-electrically-induced-atrial-fibrillation-episodes-in-canine-models
#19
X Zhang, Y Zhang, F Gao, F Zhang, Z Yang, S Ouyang, M Rao, Y Hou
Atrial fibrillation (AF) is the most prevalent heart rhythm disorder, and autonomic nervous system (ANS) is important to AF. This study aims to identify whether changes in transmitters released by ANS could reflect their activities. The right atrium (RA) groups (1-40V) included RA500 and RA1000. While ANS groups received high-frequency electrical stimulation (1-8V, 20 Hz, 2 ms), including left stellate ganglion stimulation (LSGS) andleft cervical vagus trunk stimulation (LVTS). The induced rate of AF, duration and atrial effective refractory period (AERP) were measured...
2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27447370/increased-susceptibility-to-atrial-fibrillation-secondary-to-atrial-fibrosis-in-transgenic-goats-expressing-transforming-growth-factor-%C3%AE-1
#20
Irina A Polejaeva, Ravi Ranjan, Christopher J Davies, Misha Regouski, Justin Hall, Aaron L Olsen, Qinggang Meng, Heloisa M Rutigliano, Derek J Dosdall, Nathan A Angel, Frank B Sachse, Thomas Seidel, Aaron J Thomas, Rusty Stott, Kip E Panter, Pamela M Lee, Arnaud J VAN Wettere, John R Stevens, Zhongde Wang, Rob S Macleod, Nassir F Marrouche, Kenneth L White
INTRODUCTION: Large animal models of progressive atrial fibrosis would provide an attractive platform to study relationship between structural and electrical remodeling in atrial fibrillation (AF). Here we established a new transgenic goat model of AF with cardiac specific overexpression of TGF-β1 and investigated the changes in the cardiac structure and function leading to AF. METHODS AND RESULTS: Transgenic goats with cardiac specific overexpression of constitutively active TGF-β1 were generated by somatic cell nuclear transfer...
October 2016: Journal of Cardiovascular Electrophysiology
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