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https://www.readbyqxmd.com/read/28428286/a-genetic-analysis-of-the-caenorhabditis-elegans-detoxification-response
#1
Tetsunari Fukushige, Harold E Smith, Johji Miwa, Michael W Krause, John A Hanover
Oxidative damage contributes to human diseases of aging including diabetes, cancer, and cardiovascular disorders. Reactive oxygen species resulting from xenobiotic and endogenous metabolites are sensed by a poorly understood process, triggering a cascade of regulatory factors and leading to the activation of the transcription factor Nrf2 (SKN-1 in Caenorhabditis elegans). Nrf2/SKN-1 activation promotes the induction of the Phase II detoxification system that serves to limit oxidative stress. We have extended a previous C...
April 19, 2017: Genetics
https://www.readbyqxmd.com/read/28417911/genome-wide-analyses-of-the-soybean-f-box-gene-family-in-response-to-salt-stress
#2
Qi Jia, Zhi-Xia Xiao, Fuk-Ling Wong, Song Sun, Kang-Jing Liang, Hon-Ming Lam
The F-box family is one of the largest gene families in plants that regulate diverse life processes, including salt responses. However, the knowledge of the soybean F-box genes and their roles in salt tolerance remains limited. Here, we conducted a genome-wide survey of the soybean F-box family, and their expression analysis in response to salinity via in silico analysis of online RNA-sequencing (RNA-seq) data and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) to predict their potential functions...
April 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28409535/sumoylation-e3-ligase-siz1-modulates-plant-immunity-partly-through-the-immune-receptor-gene-snc1-in-arabidopsis
#3
Mingyue Gou, Quansheng Huang, Weiqiang Qian, Zemin Zhang, Zhenhua Jia, Jian Hua
The small ubiqutin-like modifier E3 ligase SIZ1 regulates multiple processes in Arabidopsis, including salicylic-acid-dependent immune responses. However, the targets of SIZ1 in plant immunity are not known. Here, we provide evidence that the plant immune receptor nucleotide-binding leucine-rich repeat gene SNC1 partially mediates the regulation of plant immunity by SIZ1. The siz1 loss-of-function mutant has an autoimmune phenotype that is dependent on SNC1 and temperature. Overexpression of SIZ1 partially rescues autoimmune mutant phenotypes induced by activation or overaccumulation of SNC1, and the SNC1 protein amount is attenuated by SIZ1 overexpression...
April 14, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28407575/fam83d-knockdown-regulates-proliferation-migration-and-invasion-of-colorectal-cancer-through-inhibiting-fbxw7-notch-1-signalling-pathway
#4
Yu Mu, Hongzhi Zou, Beibei Chen, Yixiao Fan, Suxia Luo
Colorectal cancer is one of the most common malignant tumors in the digestive system, and in China its incidence is rising in recent years. The FAM83D family with sequence similarity 83, member D is associated with the occurrence and development of various cancers. However, in human colorectal cancer, the biological function of FAM83D and its molecular mechanism are still little known. In our study, we found that FAM83D mRNA expression level was markedly up-regulated in colorectal cancerous tissues when compared with that of adjacent normal colon tissues...
April 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28404726/regulation-of-strigolactone-biosynthesis-by-gibberellin-signaling
#5
Shinsaku Ito, Daichi Yamagami, Mikihisa Umehara, Atsushi Hanada, Satoko Yoshida, Yasuyuki Sasaki, Shunsuke Yajima, Junko Kyozuka, Miyako Ueguchi-Tanaka, Makoto Matsuoka, Ken Shirasu, Shinjiro Yamaguchi, Tadao Asami
Strigolactones (SLs) are a class of plant hormones that regulate diverse physiological processes, including shoot branching and root development. They also act as rhizosphere signaling molecules to stimulate the germination of root parasitic weeds and the branching of arbuscular mycorrhizal fungi. Although various types of cross-talk between SLs and other hormones have been reported in physiological analyses, the cross-talk between gibberellin (GA) and SLs is poorly understood. We screened for chemicals that regulate the level of SLs in rice and identified GA as a novel SL-regulating molecule...
April 12, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28397399/belinostat-exerts-anti-tumor-cytotoxicity-through-the-ubiquitin-proteasome-pathway-in-lung-squamous-cell-carcinoma
#6
Li Ren Kong, Tuan Zea Tan, Weijie Richard Ong, Chonglei Bi, Hung Huynh, Soo Chin Lee, Wee Joo Chng, Pieter Johan Adam Eichhorn, Boon Cher Goh
There have been advances in personalized therapy directed by molecular profiles in lung adenocarcinoma but not in lung squamous cell carcinoma (SCC). The lack of actionable driver oncogenes in SCC has restricted the use of small molecule inhibitors. Here, we show that SCC cell lines displayed differential sensitivities to belinostat, a pan-histone deacetylase (HDAC) inhibitor. Phosphoproteomic analysis of belinostat-treated SCC cells revealed significant downregulation of the MAPK pathway, along with induction of apoptosis...
April 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28393223/pyropia-yezoensis-peptide-pyp1%C3%A2-5-protects-against-dexamethasone%C3%A2-induced-muscle-atrophy-through-the-downregulation-of-atrogin1-mafbx-and-murf1-in-mouse-c2c12-myotubes
#7
Min-Kyeong Lee, Young-Min Kim, In-Hye Kim, Youn-Hee Choi, Taek-Jeong Nam
Skeletal muscle atrophy refers to the decline in muscle mass and strength that occurs under various conditions, including aging, starvation, cancer and other cachectic diseases. Muscle atrophy caused by aging, known as sarcopenia, primarily occurs after 50 years of age. Muscle atrophy‑related genes, including atrogin1/muscle atrophy F‑box (MAFbx) and muscle RING finger 1 (MuRF1), are expressed early in the muscle atrophy process, and their expression precedes the loss of muscle mass. The present study investigated the potential anti‑atrophic effects of the Pyropia yezoensis peptide PYP1‑5...
April 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28392107/strigolactone-and-karrikin-independent-smxl-proteins-are-central-regulators-of-phloem-formation
#8
Eva-Sophie Wallner, Vadir López-Salmerón, Ilya Belevich, Gernot Poschet, Ilona Jung, Karin Grünwald, Iris Sevilem, Eija Jokitalo, Rüdiger Hell, Yrjö Helariutta, Javier Agustí, Ivan Lebovka, Thomas Greb
Plant stem cell niches, the meristems, require long-distance transport of energy metabolites and signaling molecules along the phloem tissue. However, currently it is unclear how specification of phloem cells is controlled. Here we show that the genes SUPPRESSOR OF MAX2 1-LIKE3 (SMXL3), SMXL4, and SMXL5 act as cell-autonomous key regulators of phloem formation in Arabidopsis thaliana. The three genes form an uncharacterized subclade of the SMXL gene family that mediates hormonal strigolactone and karrikin signaling...
March 28, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28358856/dexmedetomidine-ameliorates-muscle-wasting-and-attenuates-the-alteration-of-hypothalamic-neuropeptides-and-inflammation-in-endotoxemic-rats
#9
Minhua Cheng, Tao Gao, Fengchan Xi, Chun Cao, Yan Chen, Chenyan Zhao, Qiurong Li, Wenkui Yu
Dexmedetomidine is generally used for sedaton in critically ill, it could shorten duration of mechanical ventilation, ICU stay and lower basic metabolism. However, the exact mechanism of these positive effects remains unkown. Here we investigated the hypothesis that dexmedetomidine could ameliorate muscle wasting in endotoxemic rats and whether it was related to hypothalamic neuropeptides alteration and inflammation. Fourty-eight adult male Sprague-Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) (5 mg/kg) or saline, followed by 50 μg/kg dexmedetomidine or saline administration via the femoral vein catheter (infusion at 5 μg·kg-1·hr-1)...
2017: PloS One
https://www.readbyqxmd.com/read/28341977/genetic-analysis-of-fbxo2-fbxo6-fbxo12-and-fbxo41-variants-in-han-chinese-patients-with-sporadic-parkinson-s-disease
#10
Lamei Yuan, Zhi Song, Xiong Deng, Zhijian Yang, Yan Yang, Yi Guo, Hongwei Lu, Hao Deng
Parkinson's disease (PD) is the second most common neurodegenerative disorder and has an elusive etiology. It is likely multifactorial, and genetic defects contribute to its pathogenesis. At least 25 genetic loci and 20 monogenic genes have been identified in monogenic PD. Recessive F-box protein 7 gene (FBXO7) mutations reportedly cause hereditary parkinsonism. To explore the roles of four paralogs (FBXO2, FBXO6, FBXO12, and FBXO41) in PD development, their variants (rs9614, rs28924120, rs6442117, and rs61733550, respectively) were analyzed in 502 Han Chinese patients with PD and 556 age, gender, and ethnicity-matched normal participants in mainland China...
March 24, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28341649/f-box-protein-xrep-4-is-a-new-regulator-of-the-oxidative-stress-response-in-caenorhabditis-elegans
#11
Cheng-Wei Wu, Ying Wang, Keith P Choe
The transcription factor SKN-1 in Caenorhabditis elegans is a homologue of the mammalian Nrf-2 protein and functions to promote oxidative stress resistance and longevity. SKN-1 mediates protection from reactive oxygen species (ROS) via the transcriptional activation of genes involved in antioxidant defense and phase II detoxification. Although many core regulators of SKN-1 have been identified, much remains unknown about this complex signaling pathway. We carried out an ethyl methanesulfonate (EMS) mutagenesis screen and isolated six independent mutants with attenuated SKN-1 dependent gene activation in response to acrylamide...
March 24, 2017: Genetics
https://www.readbyqxmd.com/read/28340173/f-box-protein-fbx92-affects-leaf-size-in-arabidopsis-thaliana
#12
Joke Baute, Stefanie Polyn, Jolien De Block, Jonas Blomme, Mieke Van Lijsebettens, Dirk Inzé
F-box proteins are part of one of the largest families of regulatory proteins that play important roles in protein degradation. In plants, F-box proteins are functionally very diverse, and only a small subset has been characterized in detail. Here, we identified a novel F-box protein FBX92 as a repressor of leaf growth in Arabidopsis. Overexpression of AtFBX92 resulted in plants with smaller leaves than wild type, whereas plants with reduced levels of AtFBX92 showed in contrast increased leaf growth by stimulating cell proliferation...
March 14, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28336113/effect-of-branched-chain-amino-acid-ratio-on-the-proliferation-differentiation-and-expression-levels-of-key-regulators-involved-in-protein-metabolism-of-myocytes
#13
Yehui Duan, Liming Zeng, Fengna Li, Wenlong Wang, Yinghui Li, Qiuping Guo, Yujiao Ji, Bi'e Tan, Yulong Yin
OBJECTIVES: Branched-chain amino acids (BCAAs), including leucine (Leu), isoleucine (Ile), and valine (Val), are key regulators of protein synthesis in muscle. The aim of this study was to investigate the effect of different BCAA ratios (Leu:Ile:Val) on the proliferation, differentiation, and expression levels of the regulators related to protein metabolism of C2 C12 myocytes. METHODS: Studies were conducted in C2C12 myocytes exposed to different BCAA ratios (Leu: Ile: Val = 0, 1:0...
April 2017: Nutrition
https://www.readbyqxmd.com/read/28319092/the-tdh-gcn5l1-fbxo15-kbp-axis-limits-mitochondrial-biogenesis-in-mouse-embryonic-stem%C3%A2-cells
#14
Valerio Donato, Massimo Bonora, Daniele Simoneschi, Davide Sartini, Yasusei Kudo, Anita Saraf, Laurence Florens, Michael P Washburn, Matthias Stadtfeld, Paolo Pinton, Michele Pagano
Self-renewing naive mouse embryonic stem cells (mESCs) contain few mitochondria, which increase in number and volume at the onset of differentiation. KBP (encoded by Kif1bp) is an interactor of the mitochondrial-associated kinesin Kif1Bα. We found that TDH, responsible for mitochondrial production of acetyl-CoA in mESCs, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation...
April 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28298444/scffbxo17-e3-ligase-modulates-inflammation-by-regulating-proteasomal-degradation-of-glycogen-synthase-kinase-3%C3%AE-in-lung-epithelia
#15
Tomeka Suber, Jianxin Wei, Anastasia M Jacko, Ina Nikolli, Yutong Zhao, Jing Zhao, Rama K Mallampalli
Glycogen synthase kinase-3β (GSK3β) has diverse biological roles including effects on cellular differentiation, migration, and inflammation. GSK3β phosphorylates proteins to generate phosphodegrons necessary for recognition by Skip-1/Cullin-1/F-box (SCF) E3 ubiquitin ligases leading to subsequent proteasomal degradation of these substrates. However, little is known regarding how GSK3β protein stability itself is regulated and how its stability may influence inflammation. Here we show that GSK3β is degraded by the ubiquitin-proteasome pathway in murine lung epithelial (MLE) cells through lysine 183 as an acceptor site for K48 polyubiquitination...
March 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28296622/a-cell-based-screening-approach-for-identifying-protein-degradation-regulators
#16
Scott Simanski, Marie E Maloof, Trey K Sato, Valerie Cavett, Jennifer Caldwell Busby, Nagi G Ayad
Cellular transitions are achieved by the concerted actions of regulated degradation pathways. In the case of the cell cycle, ubiquitin mediated degradation ensures unidirectional transition from one phase to another. For instance, turnover of the cell cycle regulator cyclin B1 occurs after metaphase to induce mitotic exit. To better understand pathways controlling cyclin B1 turnover, the N terminal domain of cyclin B1 was fused to luciferase to generate an N-cyclin B1-luciferase protein that can be used as a reporter for protein turnover...
March 15, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28294417/progressive-resistance-loaded-voluntary-wheel-running-increases-hypertrophy-and-differentially-affects-muscle-protein-synthesis-ribosome-biogenesis-and-proteolytic-markers-in-rat-muscle
#17
C B Mobley, A M Holland, W C Kephart, P W Mumford, R P Lowery, A N Kavazis, J M Wilson, M D Roberts
We examined if 6 weeks of progressive resistance-loaded voluntary wheel running in rats induced plantaris, soleus, and/or gastrocnemius hypertrophy and/or affected markers of translational efficiency, ribosome biogenesis, and markers of proteolysis. For 6 weeks, 8 male Sprague-Dawley rats (~9-10 weeks of age, ~300-325 g) rats were assigned to the progressive resistance-loaded voluntary wheel running model (EX), and ten rats were not trained (SED). For EX rats, the wheel-loading paradigm was as follows - days 1-7: free-wheel resistance, days 8-15: wheel resistance set to 20%-25% body mass, days 16-24: 40% body mass, days 25-32: 60% body mass, days 33-42: 40% body mass...
March 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28281075/concentration-dependent-alterations-in-gene-expression-induced-by-cadmium-in-solanum-lycopersicum
#18
Jing Hou, Xinhui Liu, Baoshan Cui, Junhong Bai, Xiangke Wang
Cadmium (Cd) toxicity in agricultural soil has received significant attention because of its higher transformation in the food chain and toxicity to humans. The aim of the present study was to develop sensitive and specific biomarkers for Cd stress. Therefore, transcriptional analyses were performed to investigate concentration-response characteristics of Cd responsive genes identified from a Solanum lycopersicum microarray. The results showed that the lowest observable adverse effect concentrations (LOAECs) of Cd to S...
March 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28242758/cdk5-fbw7-dependent-ubiquitination-and-degradation-of-ezh2-inhibits-pancreatic-cancer-cell-migration-and-invasion
#19
Xin Jin, Chong Yang, Ping Fan, Jun Xiao, Wanli Zhang, Sudong Zhan, Tao Liu, Dejie Wang, Heshui Wu
Pancreatic cancer is one of the most lethal cancer types. Enhancer of zeste homolog 2 (EZH2) is an oncogenic protein overexpressed in pancreatic cancer, and EZH2 could be a potential therapeutic target for the treatment of pancreatic cancer. Although significant progress has been made toward understanding the function and deregulation of EZH2 in cancer cells, the posttranslational regulation of EZH2 in cancer cells is still unclear. F-box and WD repeat domain-containing 7 (FBW7) acts as a tumor suppressor by targeting multiple oncoprotein substrates for ubiquitination and degradation...
April 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28236275/gene-expression-profiles-predictive-of-cold-induced-sweetening-in-potato
#20
Jonathan Neilson, M Lagüe, S Thomson, F Aurousseau, A M Murphy, B Bizimungu, V Deveaux, Y Bègue, J M E Jacobs, H H Tai
Cold storage (2-4 °C) used in potato production to suppress diseases and sprouting during storage can result in cold-induced sweetening (CIS), where reducing sugars accumulate in tuber tissue leading to undesirable browning, production of bitter flavors, and increased levels of acrylamide with frying. Potato exhibits genetic and environmental variation in resistance to CIS. The current study profiles gene expression in post-harvest tubers before cold storage using transcriptome sequencing and identifies genes whose expression is predictive for CIS...
February 24, 2017: Functional & Integrative Genomics
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