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https://www.readbyqxmd.com/read/29739417/evaluation-of-particle-radiotherapy-for-the-re-irradiation-of-recurrent-intracranial-meningioma
#1
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor's generally favorable outcome with local control rates of up to 90% after ten years, progression after RT does occur. In those cases, re-irradiation is often difficult due to the limited radiation tolerance of the surrounding tissue. The aim of this analysis is to determine the value of particle therapy with its better dose conformity and higher biological efficacy for re-irradiating recurrent intracranial meningioma...
May 8, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29587795/clinical-outcome-after-particle-therapy-for-meningiomas-of-the-skull-base-toxicity-and-local-control-in-patients-treated-with-active-rasterscanning
#2
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: Meningiomas of the skull base account for 25-30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantial morbidity. Treatment options include observation, aggressive surgical intervention, stereotactic or conventional radiotherapy. In this analysis we evaluate the outcome of 110 patients with meningiomas of the skull base treated with particle therapy. It was performed within the framework of the "clinical research group heavy ion therapy" and supported by the German Research Council (DFG, KFO 214)...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29579324/salvage-treatment-using-carbon-ion-radiation-in-patients-with-locoregionally-recurrent-nasopharyngeal-carcinoma-initial-results
#3
Jiyi Hu, Cihang Bao, Jing Gao, Xiyin Guan, Weixu Hu, Jing Yang, Chaosu Hu, Lin Kong, Jiade J Lu
BACKGROUND: Reirradiation for locoregionally recurrent nasopharyngeal carcinoma (NPC) after a definitive dose of radiotherapy (RT) is challenging and usually associated with severe toxicities. Intensity-modulated carbon ion RT (IMCT) offers physical/biologic advantages over photon-based intensity-modulated RT. Herein, the authors report their initial experience of IMCT in previously irradiated patients with locoregionally recurrent NPC. METHODS: Patients with locoregionally recurrent, poorly differentiated or undifferentiated NPC who underwent salvage therapy with IMCT at the Shanghai Proton and Heavy Ion Center between May 2015 and August 2017 were included in the current study...
March 26, 2018: Cancer
https://www.readbyqxmd.com/read/29572856/the-relative-biological-effectiveness-for-carbon-nitrogen-and-oxygen-ion-beams-using-passive-and-scanning-techniques-evaluated-with-fully-3d-silicon-microdosimeters
#4
Linh T Tran, David Bolst, Susanna Guatelli, Alex Pogossov, Marco Petasecca, Michael L F Lerch, Lachlan Chartier, Dale A Prokopovich, Mark I Reinhard, Marco Povoli, Angela Kok, Vladimir L Perevertaylo, Naruhiro Matsufuji, Tatsuaki Kanai, Michael Jackson, Anatoly B Rosenfeld
BACKGROUND: The aim of this study was to measure the microdosimetric distributions of a carbon pencil-beam scanning (PBS) and passive scattering system as well as to evaluate the relative biological effectiveness (RBE) of different ions, namely12 C,14 N and16 O, using a silicon-on-insulator (SOI) microdosimeter with well-defined 3D sensitive volumes (SV). Geant4 simulations were performed with the same experimental setup and results were compared to the experimental results for benchmarking...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29537391/-survival-a-simulation-toolkit-introducing-a-modular-approach-for-radiobiological-evaluations-in-ion-beam-therapy
#5
L Manganaro, G Russo, F Bourhaleb, F Fausti, S Giordanengo, V Monaco, R Sacchi, A Vignati, R Cirio, A Attili
One major rationale for the application of heavy ion beams in tumour therapy is their increased relative biological effectiveness (RBE). The complex dependencies of the RBE on dose, biological endpoint, position in the field etc require the use of biophysical models in treatment planning and clinical analysis. This study aims to introduce a new software, named 'Survival', to facilitate the radiobiological computations needed in ion therapy. The simulation toolkit was written in C++ and it was developed with a modular architecture in order to easily incorporate different radiobiological models...
April 5, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29531857/adenoid-cystic-carcinoma-focus-on-heavy-ion-therapy-and-molecular-imaging
#6
REVIEW
Angelo Castello, Laura Olivari, Egesta Lopci
Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest into the use of heavy particle (e.g. protons or heavy ions) in the treatment of solid tumors. However, the restricted availability of the technology has concentrated the expertise in highly specialized centers that take care and treat extreme cases and rare pathologies...
2018: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29450985/effect-of-secondary-electron-generation-on-dose-enhancement-in-lipiodol-with-and-without-a-flattening-filter
#7
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
PURPOSE: Lipiodol, which was used in transcatheter arterial chemoembolization before liver stereotactic body radiation therapy (SBRT), remains in SBRT. Previous we reported the dose enhancement in Lipiodol using 10 MV (10×) FFF beam. In this study, we compared the dose enhancement in Lipiodol and evaluated the probability of electron generation (PEG) for the dose enhancement using flattening filter (FF) and flattening filter free (FFF) beams. METHODS: FF and FFF for 6 MV (6×) and 10× beams were delivered by TrueBeam...
March 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29440626/upper-bound-dose-values-for-meson-radiation-in-heavy-ion-therapy
#8
C Rabin, M Gonçalves, S B Duarte, G A González-Sprinberg
Radiation treatment of cancer has evolved to include massive particle beams, instead of traditional irradiation procedures. Thus, patient doses and worker radiological protection have become issues of constant concern in the use of these new technologies, especially for proton- and heavy-ion-therapy. In the beam energies of interest of heavy-ion-therapy, secondary particle radiation comes from proton, neutron, and neutral and charged pions produced in the nuclear collisions of the beam with human tissue atoms...
February 14, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29414052/induction-of-reproductive-cell-death-in-caenorhabditis-elegans-across-entire-linear-energy-transfer-range-of-carbon-ion-irradiation
#9
Liangwen Chen, Huangqi Tang, Yan Du, Zhangyu Dai, Ting Wang, Lijun Wu, Libin Zhou, Po Bian
Heavy-ion radiation has attracted extensive attention as an effective cancer therapy because of the varying energy deposition along its track and its high cell-killing effect. Reproductive cell death (RCD), also known as clonogenic death, is an important mode of death of the cancer cells after radiotherapy. Although RCD induced by heavy-ion irradiation with various linear energy transfers has been demonstrated using clonogenic assay in vitro, little is known about the distribution of RCD across the range of heavy-ion irradiation at the level of whole organisms...
March 2018: DNA Repair
https://www.readbyqxmd.com/read/29384493/iterative-reconstruction-with-boundary-detection-for-carbon-ion-computed-tomography
#10
Deepak Shrestha, Nan Qin, You Zhang, Faraz Kalantari, Shanzhou Niu, Xun Jia, Arnold Pompos, Steve Jiang, Jing Wang
In heavy ion radiation therapy, improving the accuracy in range prediction of the ions inside the patient's body has become essential. Accurate localization of the Bragg peak provides greater conformity of the tumor while sparing healthy tissues. We investigated the use of carbon ions directly for computed tomography (carbon CT) to create the relative stopping power map of a patient's body. The Geant4 toolkit was used to perform a Monte Carlo simulation of the carbon ion trajectories, to study their lateral and angular deflections and the most likely paths, using a water phantom...
February 26, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29384168/analysis-of-redox-states-of-protic-and-aprotic-solutions-irradiated-by-low-linear-energy-transfer-carbon-ion-beams-using-a-2-2-diphenyl-1-picrylhydrazyl-radical
#11
Ikuo Nakanishi, Shinichi Yamashita, Takashi Shimokawa, Masato Kamibayashi, Emiko Sekine-Suzuki, Megumi Ueno, Yukihiro Ogawa, Toshihiko Ozawa, Ken-Ichiro Matsumoto
The quantitative evaluation of changes in the redox state induced by low linear energy transfer (LET) radiations such as the plateau region of heavy-ion beams via formation of reactive oxygen species is of considerable importance to eliminate the adverse effects of radiation therapy on normal tissues adjacent to a tumour. In this study, a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH˙) was used as a redox probe to estimate the redox states of protic and aprotic solutions irradiated by low LET carbon-ion (C-ion) beams...
February 21, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29365418/-the-preliminary-report-of-a-registration-clinical-trial-of-proton-and-heavy-ion-irradiation
#12
J D Lu, M Ye, Q Guo, J F Fu, X M Moyers, S T Zhang, N Y Mao, Y S Kong, X Hsi, X Y Shahnazi, J H Zhao, B Zhang, J Y Ma, Y X Z Lai, W Zhang, J Ma, L N Gao, X M Cai, S Guan, G L Zhang, J F Wu, L Cheng, Z Sheng, X M Ren, Jun Zhao, Lining Sun, Guoliang Jiang
Objective: To verify the safety and efficacy of IONTRIS particle therapy system (IONTRIS) in clinical implementation. Methods: Between 6.2014 and 8.2014, a total of 35 patients were enrolled into this trial: 31 males and 4 females with a median age of 69 yrs (range 39-80). Ten patients had locally recurrent head and neck tumors after surgery, 4 cases with thoracic malignancies, 1 case with hepatocellular carcinoma, 1 case with retroperitoneal sarcoma, and 19 cases with non-metastatic prostate carcinomas. Phantom dose verification was mandatory for each field before the start of radiation...
January 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29348734/energy-spectrum-and-dose-enhancement-due-to-the-depth-of-the-lipiodol-position-using-flattened-and-unflattened-beams
#13
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Tomoki Kimura, Tatsuhiko Suzuki, Masato Tsuneda, Sodai Tanaka, Kazunari Hioki, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
Aim: Lipiodol was used for stereotactic body radiotherapy combining trans arterial chemoembolization. Lipiodol used for tumour seeking in trans arterial chemoembolization remains in stereotactic body radiation therapy. In our previous study, we reported the dose enhancement effect in Lipiodol with 10× flattening-filter-free (FFF). The objective of our study was to evaluate the dose enhancement and energy spectrum of photons and electrons due to the Lipiodol depth with flattened (FF) and FFF beams...
January 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29343841/microdosimetric-modeling-of-biological-effectiveness-for-boron-neutron-capture-therapy-considering-intra-and-intercellular-heterogeneity-in-10b-distribution
#14
Tatsuhiko Sato, Shin-Ichiro Masunaga, Hiroaki Kumada, Nobuyuki Hamada
We here propose a new model for estimating the biological effectiveness for boron neutron capture therapy (BNCT) considering intra- and intercellular heterogeneity in 10B distribution. The new model was developed from our previously established stochastic microdosimetric kinetic model that determines the surviving fraction of cells irradiated with any radiations. In the model, the probability density of the absorbed doses in microscopic scales is the fundamental physical index for characterizing the radiation fields...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320576/targeting-dna-repair-with-pnkp-inhibition-sensitizes-radioresistant-prostate-cancer-cells-to-high-let-radiation
#15
Pallavi Srivastava, Asitikantha Sarma, Chandra Mohini Chaturvedi
High linear energy transfer (LET) radiation or heavy ion such as carbon ion radiation is used as a method for advanced radiotherapy in the treatment of cancer. It has many advantages over the conventional photon based radiotherapy using Co-60 gamma or high energy X-rays from a Linear Accelerator. However, charged particle therapy is very costly. One way to reduce the cost as well as irradiation effects on normal cells is to reduce the dose of radiation by enhancing the radiation sensitivity through the use of a radiomodulator...
2018: PloS One
https://www.readbyqxmd.com/read/29240558/a-modified-microdosimetric-kinetic-model-for-relative-biological-effectiveness-calculation
#16
Yizheng Chen, Junli Li, Chunyan Li, Rui Qiu, Zhen Wu
In the heavy ion therapy, not only the distribution of physical absorbed dose, but also the relative biological effectiveness (RBE) weighted dose needs to be taken into account. The microdosimetric kinetic model (MKM) can predict the RBE value of heavy ions with saturation-corrected dose-mean specific energy, which has been used in clinical treatment planning at the National Institute of Radiological Sciences. In the theoretical assumption of the MKM, the yield of the primary lesion is independent of the radiation quality, while the experimental data shows that DNA double strand break (DSB) yield, considered as the main primary lesion, depends on the LET of the particle...
December 14, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#17
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29151472/-fricke-gel-dosimeters
#18
Takuya Maeyama
Fricke gel dosimeters are based on the aqueous ferrous sulfate solution that has been used as a reliable chemical dosimeter for more than 90 years. The amount of radiation-induced oxidation of ferrous ions to ferric ions could be evaluated three-dimensionally via optical computed tomography (OCT) or magnetic resonance imaging (MRI). Three-dimensional dosimetry is expected to be a useful tool, in particular, for the verification of complex radiation dose planning in advanced radiation cancer therapy. Compared with other 3D gel dosimeters, there are several problems such as retention of dose distribution or dose sensitivity; however, they can easily be prepared in a chemistry laboratory...
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/29139207/patient-reported-outcomes-of-slow-single-arc-rotation-do-we-need-rotating-gantries
#19
Brendan Whelan, Miriam Welgampola, Leigh McGarvie, Kuldeep Makhija, Robin M Turner, Lois Holloway, Ilana Feain, Michael Jackson, Michael Barton, Paul Keall
INTRODUCTION: Patient rotation could greatly simplify radiation therapy delivery, with particularly important ramifications for fixed beam treatment with protons, heavy ions, MRI-Linacs, and low cost Linacs. Patient tolerance is often cited as a barrier to widespread implementation to patient rotation; however, no quantitative data addressing this issue exists. In this study, patient reported experiences of slow, single arc rotation in upright (sitting) and lying orientations are reported...
November 15, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29121984/carbon-ion-radiotherapy-impact-of-tumor-differentiation-on-local-control-in-experimental-prostate-carcinomas
#20
Christin Glowa, Peter Peschke, Stephan Brons, Oliver C Neels, Klaus Kopka, Jürgen Debus, Christian P Karger
BACKGROUND: To summarize the research activities of the "clinical research group heavy ion therapy", funded by the German Research Foundation (DFG, KFO 214), on the impact of intrinsic tumor characteristics (grading, hypoxia) on local tumor control after carbon (12 C-) ion- and photon irradiations. METHODS: Three sublines of syngeneic rat prostate tumors (R3327) with various differentiation levels (highly (-H), moderately (-HI) or anaplastic (-AT1), (diameter 10 mm) were irradiated with 1, 2 and 6 fractions of either12 C-ions or 6 MV photons using increasing dose levels...
November 9, 2017: Radiation Oncology
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