Huan Zhao, Qian Xue, Cong Li, Qingchuan Wang, Shichao Han, Yongsheng Zhou, Tao Yang, Yingli Xie, Hao Fu, Changbo Lu, Fancheng Meng, Ming Zhang, Yan Zhang, Xianglong Wu, Shengxi Wu, Min Zhuo, Hui Xu
The anterior cingulate cortex (ACC) serves as a critical hub for the anxiety and pain perception. The large-conductance Ca2+ -activated potassium channels, or BKCa channels, are ubiquitously expressed throughout the central nervous system including the cingulate cortex. However, what changes of cortical BKCa channels undergo in the ACC remains unknown in pain-related anxiety. In the present study, a significant upregulation of synaptic and non-synaptic BKCa channel accessory β4 subunits in the ACC was accompanied with pain-associated anxiety-like behaviors in the chronic compression of multiple dorsal root ganglia (mCCD) of the rat...
February 18, 2020: Molecular Brain