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https://www.readbyqxmd.com/read/28238940/dynamic-landscape-models-of-coevolutionary-games
#1
Hendrik Richter
Players of coevolutionary games may update not only their strategies but also their networks of interaction. Based on interpreting the payoff of players as fitness, dynamic landscape models are proposed. The modeling procedure is carried out for Prisoner's Dilemma (PD) and Snowdrift (SD) games that both use either birth-death (BD) or death-birth (DB) strategy updating. The main focus is on using dynamic fitness landscapes as a mathematical model of coevolutionary game dynamics. Hence, an alternative tool for analyzing coevolutionary games becomes available, and landscape measures such as modality, ruggedness and information content can be computed and analyzed...
February 23, 2017: Bio Systems
https://www.readbyqxmd.com/read/28238733/fragmentation-of-the-crispr-cas-type-i-b-signature-protein-cas8b
#2
Hagen Richter, Judith Rompf, Julia Wiegel, Kristina Rau, Lennart Randau
BACKGROUND: CRISPR arrays are transcribed into long precursor RNA species, which are further processed into mature CRISPR RNAs (crRNAs). Cas proteins utilize these crRNAs, which contain spacer sequences that can be derived from mobile genetic elements, to mediate immunity during a reoccurring virus infection. Type I CRISPR-Cas systems are defined by the presence of different Cascade interference complexes containing large and small subunits that play major roles during target DNA selection...
February 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28238561/magnetic-resonance-imaging-of-the-inferior-alveolar-nerve-with-special-regard-to-metal-artifact-reduction
#3
Monika Probst, Vivien Richter, Jochen Weitz, Jan Stefan Kirschke, Carl Ganter, Matthias Troeltzsch, Mathias Nittka, Carl-Peter Cornelius, Claus Zimmer, Florian Andreas Probst
PURPOSE: Magnetic resonance imaging (MRI) is an excellent imaging modality for displaying peripheral nerves. Since the knowledge about MRI of the inferior alveolar nerve (IAN) is limited, this pilot study aims to identify the prospects and limitations of MRI of the IAN, with special consideration of metal artifacts. MATERIALS AND METHODS: Initially, in vitro MRI of a dental implant was performed to establish an optimized protocol for metal artifact reduction using WARP sequences (a software package provided by Siemens Healthcare, Erlangen, Germany) including view angle tilting (VAT) and slice-encoding metal artifact correction (SEMAC) techniques...
January 25, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28236630/growth-attainment-in-german-children-born-preterm-and-cardiovascular-risk-factors-in-adolescence-analysis-of-the-population-representative-kiggs-data
#4
Renate L Bergmann, Karl E Bergmann, Rolf Richter, Martin Schlaud, Wolfgang Henrich, Alexander Weichert
AIM: To compare the growth attainment of preterm children and their cardiovascular risk factors at adolescence with the values measured in term children in Germany. METHODS: About 17,641 children aged 0 to <18 years were studied between 2003 and 2006 in the population representative German KiGGS survey ("German Health Interview and Examination Survey for Children and Adolescents") using questionnaires, physical examinations, standardized anthropometric and blood pressure measurements, and blood sample analyses...
February 25, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28235676/the-mek1-inhibitors-uo126-and-pd98059-block-pdgf-ab-induced-phosphorylation-of-threonine-292-in-porcine-smooth-muscle-cells
#5
Thomas Kubin, Ayse Cetinkaya, Markus Schönburg, Andres Beiras-Fernandez, Thomas Walther, Manfred Richter
PDGF-AB and FGF-2 (GFs) induce smooth muscle cell (SMC) proliferation which is indispensible for arteriogenesis. While there is common agreement that GFs stimulate SMC proliferation through phosphorylation (P-) of MEK1/2 at Ser218/222, we previously demonstrated that the MEK inhibitors PD98059 and UO126 did not inhibit P-Ser218/222 as originally proposed but caused strong hyperphosphorylation. Here, we demonstrate that GFs increased phosphorylation of MEK1 at Thr292 while UO126 and PD98059 blocked this phosphorylation...
February 21, 2017: Cytokine
https://www.readbyqxmd.com/read/28228559/targeting-influenza-virus-hemagglutinin-to-xcr1-dendritic-cells-in-the-absence-of-receptor-mediated-endocytosis-enhances-protective-antibody-responses
#6
Arnar Gudjonsson, Anna Lysén, Sreekumar Balan, Vibeke Sundvold-Gjerstad, Catharina Arnold-Schrauf, Lisa Richter, Espen S Bækkevold, Marc Dalod, Bjarne Bogen, Even Fossum
Targeting Ags to conventional dendritic cells can enhance Ag-specific immune responses. Although most studies have focused on the induction of T cell responses, the mechanisms by which targeting improves Ab responses are poorly understood. In this study we present data on the use of human XCL1 (hXCL1) and hXCL2 fusion vaccines in a murine model. We show that the human chemokines bound type 1 conventional dendritic cells (cDC1), and that immunization with influenza virus hemagglutinin fused to hXCL1 or hXCL2 induced full protection against influenza challenge...
February 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28228478/an-engineered-tgf-%C3%AE-monomer-that-functions-as-a-dominant-negative-to-block-tgf-%C3%AE-signaling
#7
Sun Kyung Kim, Lindsey Barron, Cynthia S Hinck, Elyse M Petrunak, Kristin E Cano, Avinash Thangirala, Brian Iskra, Molly Brothers, Machell Vonberg, Belinda Leal, Blair Richter, Ravindra Kodali, Alex B Taylor, Shoucheng Du, Christopher O Barnes, Traian Sulea, Guillermo Calero, P John Hart, Matthew J Hart, Borries Demeler, Andrew P Hinck
The transforming growth factor beta isoforms, TGF-β1, -β2, and -β3 are small secreted homodimeric signaling proteins with essential roles in regulating the adaptive immune system and maintaining the extracellular matrix. However, dysregulation of the TGF-β pathway is responsible for promoting the progression of several human diseases, including cancer and fibrosis. In spite of the known importance of TGF-βs in promoting disease progression, no inhibitors have been approved for use in humans. Herein, we describe an engineered TGF-β monomer, lacking the heel helix, a structural motif essential for binding the TGF-β type I receptor, TβRI, but dispensible for binding the other receptor required for TGF-β signaling, the TGF-β type II receptor, TβRII, as an alternative therapeutic modality for blocking TGF-β signaling in humans...
February 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28224984/abnormal-strong-burn-in-degradation-of-highly-efficient-polymer-solar-cells-caused-by-spinodal-donor-acceptor-demixing
#8
Ning Li, José Darío Perea, Thaer Kassar, Moses Richter, Thomas Heumueller, Gebhard J Matt, Yi Hou, Nusret S Güldal, Haiwei Chen, Shi Chen, Stefan Langner, Marvin Berlinghof, Tobias Unruh, Christoph J Brabec
The performance of organic solar cells is determined by the delicate, meticulously optimized bulk-heterojunction microstructure, which consists of finely mixed and relatively separated donor/acceptor regions. Here we demonstrate an abnormal strong burn-in degradation in highly efficient polymer solar cells caused by spinodal demixing of the donor and acceptor phases, which dramatically reduces charge generation and can be attributed to the inherently low miscibility of both materials. Even though the microstructure can be kinetically tuned for achieving high-performance, the inherently low miscibility of donor and acceptor leads to spontaneous phase separation in the solid state, even at room temperature and in the dark...
February 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28223920/therapeutic-potential-of-secreted-amyloid-precursor-protein-apps%C3%AE
#9
REVIEW
Bruce G Mockett, Max Richter, Wickliffe C Abraham, Ulrike C Müller
Cleavage of the amyloid precursor protein (APP) by α-secretase generates an extracellularly released fragment termed secreted APP-alpha (APPsα). Not only is this process of interest due to the cleavage of APP within the amyloid-beta sequence, but APPsα itself has many physiological properties that suggest its great potential as a therapeutic target. For example, APPsα is neurotrophic, neuroprotective, neurogenic, a stimulator of protein synthesis and gene expression, and enhances long-term potentiation (LTP) and memory...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28223144/combination-of-hand-held-probe-and-microscopy-for-fluorescence-guided-surgery-in-the-brain-tumor-marginal-zone
#10
Johan Richter, Neda Haj-Hosseini, Martin Hallbeck, Karin Wårdell
BACKGROUND: Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-micsorcope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection. METHODS: Eighteen operations were performed on 16 patients with suspected high-grade glioma...
February 18, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28222892/fdg-uptake-in-normal-tissues-assessed-by-pet-during-treatment-has-prognostic-value-for-treatment-results-in-head-and-neck-squamous-cell-carcinomas-undergoing-radiochemotherapy
#11
Sebastian Zschaeck, Steffen Löck, Stefan Leger, Robert Haase, Anna Bandurska-Luque, Steffen Appold, Jörg Kotzerke, Daniel Zips, Christian Richter, Volker Gudziol, Andreas Schreiber, Klaus Zöphel, Michael Baumann, Mechthild Krause
BACKGROUND AND PURPOSE: Pronounced early side effects have been suggested to be a positive prognostic factor in patients undergoing chemo-radio-therapy (CRT) for head and neck squamous cell carcinomas (HNSCC). We assessed the utility of positron emission tomography (PET) during treatment to analyze the correlation of 18F-fluorodeoxyglucose (FDG) uptake in off target structures within the irradiated volume with outcome. MATERIAL AND METHODS: Two independent cohorts of patients with locally advanced HNSCC, both treated within prospective clinical imaging trials with curatively intended CRT were retrospectively analyzed...
February 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28220251/triple-aim-improvement-for-individuals-services-and-society-in-dementia-care-the-dementianet-collaborative-care-approach
#12
M S Nieuwboer, A Richters, M A van der Marck
BACKGROUND: A redesigning of primary care is required to meet dementia patients' needs. In the Netherlands, current dementia care still falls short in areas including ad hoc collaboration, lack of feedback on quality to professionals involved, and insufficient implementation of established multidisciplinary guidelines. OBJECTIVE: DementiaNet is a collaborative care approach, which aims to reduce the burden of the disease on individuals, healthcare services and society via network-based care that encourages collaboration, enhances knowledge and skills and stimulates quality improvement cycles...
February 20, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28220149/chemical-characterization-of-mainstream-smoke-from-spectrum-variable-nicotine-research-cigarettes
#13
Yan S Ding, Patricia Richter, Bryan Hearn, Liqin Zhang, Roberto Bravo, Xizheng Yan, Jose J Perez, Michele Chan, Jared Hughes, Patrick Chen, Wayne Chen, Joshua Wong, Sydney Holmberg, Shakia Smith, Morgan Larango, Liza Valentín-Blasini, Clifford H Watson
OBJECTIVE: Our objective was to characterize mainstream smoke constituent deliveries from SPECTRUM variable nicotine research cigarettes under 2 machine smoking regimens. SPECTRUM cigarettes are manufactured by the 22nd Century company for the National Institute on Drug Abuse, National Institutes of Health to contain varying (including reduced) levels of nicotine. METHODS: Mainstream smoke constituent deliveries of "tar," nicotine, carbon monoxide, tobacco-specific nitrosamines (N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)), benzo[a]pyrene, aromatic amines, and carbonyls were analyzed in 23 varieties of SPECTRUM cigarettes using ISO 17025 accredited methods...
December 1, 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28220095/don-t-lose-your-brain-at-work-the-role-of-recurrent-novelty-at-work-in-cognitive-and-brain-aging
#14
Jan Oltmanns, Ben Godde, Axel H Winneke, Götz Richter, Claudia Niemann, Claudia Voelcker-Rehage, Klaus Schömann, Ursula M Staudinger
Cognitive and brain aging is strongly influenced by everyday settings such as work demands. Long-term exposure to low job complexity, for instance, has detrimental effects on cognitive functioning and regional gray matter (GM) volume. Brain and cognition, however, are also characterized by plasticity. We postulate that the experience of novelty (at work) is one important trigger of plasticity. We investigated the cumulative effect of recurrent exposure to work-task changes (WTC) at low levels of job complexity on GM volume and cognitive functioning of middle-aged production workers across a time window of 17 years...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28218627/gata4-dependent-organ-specific-endothelial-differentiation-controls-liver-development-and-embryonic-hematopoiesis
#15
Cyrill Géraud, Philipp-Sebastian Koch, Johanna Zierow, Kay Klapproth, Katrin Busch, Victor Olsavszky, Thomas Leibing, Alexandra Demory, Friederike Ulbrich, Miriam Diett, Sandhya Singh, Carsten Sticht, Katja Breitkopf-Heinlein, Karsten Richter, Sanna-Maria Karppinen, Taina Pihlajaniemi, Bernd Arnold, Hans-Reimer Rodewald, Hellmut G Augustin, Kai Schledzewski, Sergij Goerdt
Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment. Microvascular ECs instruct neighboring cells in their organ-specific vascular niches through angiocrine factors, which include secreted growth factors (angiokines), extracellular matrix molecules, and transmembrane proteins. However, the molecular regulators that drive organ-specific microvascular transcriptional programs and thereby regulate angiodiversity are largely elusive. In contrast to other ECs, which form a continuous cell layer, liver sinusoidal ECs (LSECs) constitute discontinuous, permeable microvessels...
February 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28218069/concomitant-presence-of-cd5-positive-diffuse-large-b-lymphoma-and-monoclonal-b-cells-with-cll-immunophenotype-is-it-richter-s-transformation
#16
Sabina Langer, Jasmita Dass, Suchi Mittal, Shyam Aggarwal
No abstract text is available yet for this article.
February 20, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28217928/fast-determination-of-codeine-orphenadrine-promethazine-scopolamine-tramadol-and-paracetamol-in-pharmaceutical-formulations-by-capillary-electrophoresis
#17
Rafael R Cunha, Michelle M A C Ribeiro, Rodrigo A A Muñoz, Eduardo M Richter
Paracetamol is an active ingredient commonly found in pharmaceutical formulations in combination with one of the following compounds: codeine, orphenadrine, promethazine, scopolamine, and tramadol. In this work, we propose a unique analytical method for determination of these active ingredients in pharmaceutical samples. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation was achieved on a fused silica capillary (50 cm total length, 40 cm effective length, and 50 μm id) using an optimized background electrolyte composed of 20 mmol L(-1) β-alanine/4 mmol L(-1) sodium chloride/4 μmol L(-1) sodium hydroxide (pH = 9...
February 20, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28217774/internal-structure-and-phase-transition-behavior-of-stimuli-responsive-microgels-in-peg-melts
#18
Florian Schneider, Andreea Balaceanu, Zhenyu Di, Yuri B Melnichenko, Jürgen Allgaier, Andrij Pich, Gerald J Schneider, Dieter Richter
In this work we investigated the behaviour of stimuli-responsive poly(N-vinylcaprolactam) (PVCL) microgels in poly(ethylene glycol) (PEGs) with a linear architecture. We performed small-angle neutron scattering (SANS) experiments at two different microgel concentrations and various temperatures. The results were compared with those on PVCL microgels in water. PVCL in PEG (molecular weight MW = 2 kg mol(-1)) exhibits a volume phase transition temperature (VPTT) at a temperature between 160 and 180 °C. The diameter of the swollen microgel is only slightly smaller than in water...
February 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28214606/payload-release-by-liposome-burst-thermal-collapse-of-microgels-induces-satellite-destruction
#19
Alexander Yaroslavov, Irina Panova, Andrey Sybachin, Vasiliy Spiridonov, Alexander Zezin, Olga Mergel, Arjan Gelissen, Rahul Tiwari, Felix Plamper, Walter Richtering, Fredric Menger
No abstract text is available yet for this article.
February 16, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28213283/pyrrolo-3-2-6-7-cyclohepta-1-2-b-pyridines-with-potent-photo-antiproliferative-activity
#20
Virginia Spanò, Daniele Giallombardo, Vincenzo Cilibrasi, Barbara Parrino, Anna Carbone, Alessandra Montalbano, Ilaria Frasson, Alessia Salvador, Sara N Richter, Filippo Doria, Mauro Freccero, Stella Cascioferro, Patrizia Diana, Girolamo Cirrincione, Paola Barraja
Pyrrolo[3',2':6,7]cyclohepta[1,2-b]pyridines were synthesized as a new class of tricyclic system in which the pyridine ring is annelated to a cycloheptapyrrole scaffold, with the aim of obtaining new photosensitizing agents with improved antiproliferative activity and lower undesired toxic effects. A versatile synthetic pathway was approached, which allowed the isolation of derivatives of the title ring system with a good substitution pattern on the pyrrole moiety. Photobiological studies revealed that the majority of the new compounds showed a potent cytotoxic effect upon photoactivation with light of the proper wavelength, especially when decorated with a 2-ethoxycabonyl group and a N-benzyl substituted moiety, with EC50 values reaching the submicromolar level...
February 7, 2017: European Journal of Medicinal Chemistry
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