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https://www.readbyqxmd.com/read/28109754/game-theory-in-epigenetic-reprogramming-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#1
Fei-Man Hsu, Pao-Yang Chen
No abstract text is available yet for this article.
January 12, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28109753/using-game-theory-to-investigate-the-epigenetic-control-mechanisms-of-embryo-development-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#2
Le Zhang, Shaoxiang Zhang
A body of research [1-7] has already shown that epigenetic reprogramming plays a critical role in maintaining the normal development of embryos. However, the mechanistic quantitation of the epigenetic interactions between sperms and oocytes and the related impact on embryo development are still not clear [6,7]. In this study, Wang et al., [8] develop a modeling framework that addresses this question by integrating game theory and the latest discoveries of the epigenetic control of embryo development.
January 18, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28104825/effect-of-bovine-oviductal-extracellular-vesicles-on-embryo-development-and-quality-in-vitro
#3
Ricaurte Lopera-Vasquez, Meriem Hamdi, Veronica Maillo, Alfonso Gutierrez-Adan, Pablo Bermejo-Alvarez, Miguel Angel Ramirez, Maria Yañez-Mo, Dimitrios Rizos
The aim of this study was to evaluate the effect of extracellular vesicles (EV) from oviductal fluid (OF), either from the ampulla or isthmus, on the development and quality of in vitro cultured bovine embryos. Zygotes were cultured in synthetic oviduct fluid (SOF+3mg/ml BSA) without calf serum (C- group), in the presence of 3x105 EV/ml from ampullary or isthmic OF at either 1x104xg (10k) and 1x105xg (100k), and compared with SOF+5% FCS (C+ group). OF-EV size and concentration were assessed by electron microscopy and nanotracking analysis system...
January 19, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28102431/totipotency-in-the-mouse
#4
REVIEW
Guangming Wu, Lei Lei, Hans R Schöler
In mammals, the unicellular zygote starts the process of embryogenesis and differentiates into all types of somatic cells, including both fetal and extraembryonic lineages-in a highly organized manner to eventually give rise to an entire multicellular organism comprising more than 200 different tissue types. This feature is referred to as totipotency. Upon fertilization, oocyte maternal factors epigenetically reprogram the genomes of the terminally differentiated oocyte and spermatozoon and turn the zygote into a totipotent cell...
January 19, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28100783/dual-functional-roles-of-molecular-beacon-a-microrna-detector-and-inhibitor
#5
Wai Ming Li, Ching-Man Chan, Andrew L Miller, Chow H Lee
MicroRNAs are essential in many cellular processes. The ability to detect microRNAs is important for understanding its function and biogenesis. This study is aimed at using a molecular beacon to detect miR-430 in developing zebrafish embryos as a proof of principle. miR-430 is crucial for the clearance of maternal mRNA during maternal zygotic transition (MZT) in embryonic development. Despite its known function, the temporal and spatial expression of miR-430 remains unclear. We used various imaging techniques, including laser scanning confocal microscopy, spinning disk and lightsheet microscopy, to study the localization of miR-430 and any developmental defects possibly caused by the molecular beacon...
January 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28098238/expression-of-the-novel-maternal-centrosome-assembly-factor-wdr8-is-required-for-vertebrate-embryonic-mitoses
#6
Daigo Inoue, Manuel Stemmer, Thomas Thumberger, Thomas Ruppert, Felix Bärenz, Joachim Wittbrodt, Oliver J Gruss
The assembly of the first centrosome occurs upon fertilisation when male centrioles recruit pericentriolar material (PCM) from the egg cytoplasm. The mechanisms underlying the proper assembly of centrosomes during early embryogenesis remain obscure. We identify Wdr8 as a novel maternally essential protein that is required for centrosome assembly during embryonic mitoses of medaka (Oryzias latipes). By CRISPR-Cas9-mediated knockout, maternal/zygotic Wdr8-null (m/zWdr8(-/-)) blastomeres exhibit severe defects in centrosome structure that lead to asymmetric division, multipolar mitotic spindles and chromosome alignment errors...
January 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28098234/maternal-cortisol-stimulates-neurogenesis-and-affects-larval-behaviour-in-zebrafish
#7
Carol Best, Deborah M Kurrasch, Mathilakath M Vijayan
Excess glucocorticoid transferred from stressed mother to the embryo affects developing vertebrate offspring, but the underlying programming events are unclear. In this study, we tested the hypothesis that increased zygotic glucocorticoid deposition, mimicking a maternal stress scenario, modifies early brain development and larval behaviour in zebrafish (Danio rerio). Cortisol was microinjected into the yolk at one cell-stage, to mimic maternal transfer, and the larvae [96 hours post-fertilization (hpf)] displayed increased activity in light and a reduction in thigmotaxis, a behavioural model for anxiety, suggesting an increased propensity for boldness...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28095407/a-novel-imprinted-gene-nuwa-controls-mitochondrial-function-in-early-seed-development-in-arabidopsis
#8
Shan He, Yan Sun, Qian Yang, Xiangyu Zhang, Qingpei Huang, Peng Zhao, Mengxiang Sun, Jingjing Liu, Weiqiang Qian, Genji Qin, Hongya Gu, Li-Jia Qu
Imprinted genes display biased expression of paternal and maternal alleles- and are only found in mammals and flowering plants. Compared to several hundred imprinted genes that are functionally characterized in mammals, very few imprinted genes were confirmed in plants and even fewer of them have been functionally investigated. Here, we report a new imprinted gene, NUWA, in plants. NUWA is an essential gene, because loss of its function resulted in reduced transmission through the female gametophyte and defective cell/nuclear proliferation in early Arabidopsis embryo and endosperm...
January 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28094150/applications-and-extensions-of-epigenetic-game-theory-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#9
https://www.readbyqxmd.com/read/28094148/epigenetic-battle-of-the-sexes-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#10
https://www.readbyqxmd.com/read/28094147/integrating-evolutionary-game-theory-into-epigenetic-study-of-embryonic-development-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#11
https://www.readbyqxmd.com/read/28094142/epigenetic-game-theory-and-its-application-in-plants-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#12
Yuan-Ming Zhang, Yinghao Zhang, Mingyue Guo
No abstract text is available yet for this article.
January 13, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28094036/centriole-remodeling-during-spermiogenesis-in-drosophila
#13
Atul Khire, Kyoung H Jo, Dong Kong, Tara Akhshi, Stephanie Blachon, Anthony R Cekic, Sarah Hynek, Andrew Ha, Jadranka Loncarek, Vito Mennella, Tomer Avidor-Reiss
The first cell of an animal (zygote) requires centrosomes that are assembled from paternally inherited centrioles and maternally inherited pericentriolar material (PCM) [1]. In some animals, sperm centrioles with typical ultrastructure are the origin of the first centrosomes in the zygote [2-4]. In other animals, however, sperm centrioles lose their proteins and are thought to be degenerated and non-functional during spermiogenesis [5, 6]. Here, we show that the two sperm centrioles (the giant centriole [GC] and the proximal centriole-like structure [PCL]) in Drosophila melanogaster are remodeled during spermiogenesis through protein enrichment and ultrastructure modification in parallel to previously described centrosomal reduction [7]...
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/28091576/adjuvant-and-carrier-protein-dependent-t-cell-priming-promotes-a-robust-antibody-response-against-the-plasmodium-falciparum-pfs25-vaccine-candidate
#14
Andrea J Radtke, Charles F Anderson, Nicolas Riteau, Kelly Rausch, Puthupparampil Scaria, Emily R Kelnhofer, Randall F Howard, Alan Sher, Ronald N Germain, Patrick Duffy
Humoral immune responses have the potential to maintain protective antibody levels for years due to the immunoglobulin-secreting activity of long-lived plasma cells (LLPCs). However, many subunit vaccines under development fail to generate robust LLPC responses, and therefore a variety of strategies are being employed to overcome this limitation, including conjugation to carrier proteins and/or formulation with potent adjuvants. Pfs25, an antigen expressed on malaria zygotes and ookinetes, is a leading transmission blocking vaccine (TBV) candidate for Plasmodium falciparum...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28089374/epigenetic-information-in-gametes-gaming-from-before-fertilization-comment-on-epigenetic-game-theory-how-to-compute-the-epigenetic-control-of-maternal-to-zygotic-transition-by-qian-wang-et-al
#15
Junchao Shi, Xudong Zhang, Ying Liu, Qi Chen
No abstract text is available yet for this article.
January 6, 2017: Physics of Life Reviews
https://www.readbyqxmd.com/read/28088031/the-timing-of-zygotic-genome-activation
#16
REVIEW
Máté Pálfy, Shai R Joseph, Nadine L Vastenhouw
After fertilization, the embryonic genome is inactive until transcription is initiated during the maternal-to-zygotic transition. How the onset of transcription is regulated in a precisely timed manner, however, is a long standing question in biology. Several mechanisms have been shown to contribute to the temporal regulation of genome activation but none of them can fully explain the general absence of transcription as well the gene specific onset that follows. Here we review the work that has been done toward elucidating the mechanisms underlying the temporal regulation of transcription in embryos...
January 11, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28087625/faithful-mrna-splicing-depends-on-the-prp19-complex-subunit-faint-sausage-and-is-required-for-tracheal-branching-morphogenesis-in-drosophila
#17
Julia Sauerwald, Charlotte Soneson, Mark D Robinson, Stefan Luschnig
Morphogenesis requires the dynamic regulation of gene expression, including transcription, mRNA maturation and translation. Dysfunction of the general mRNA splicing machinery can cause surprisingly specific cellular phenotypes, but the basis for these effects is not clear. Here we show that the Drosophila faint sausage (fas) locus, implicated in epithelial morphogenesis and previously reported to encode a secreted immunoglobulin domain protein, in fact encodes a subunit of the spliceosome-activating Prp19 complex, which is essential for efficient pre-mRNA splicing...
January 13, 2017: Development
https://www.readbyqxmd.com/read/28087610/long-non-coding-rna-exchange-during-the-oocyte-to-embryo-transition-in-mice
#18
Rosa Karlic, Sravya Ganesh, Vedran Franke, Eliska Svobodova, Jana Urbanova, Yutaka Suzuki, Fugaku Aoki, Kristian Vlahovicek, Petr Svoboda
The oocyte-to-embryo transition (OET) transforms a differentiated gamete into pluripotent blastomeres. The accompanying maternal-zygotic RNA exchange involves remodeling of the long non-coding RNA (lncRNA) pool. Here, we used next generation sequencing and de novo transcript assembly to define the core population of 1,600 lncRNAs expressed during the OET (lncRNAs). Relative to mRNAs, OET lncRNAs were less expressed and had shorter transcripts, mainly due to fewer exons and shorter 5' terminal exons. Approximately half of OET lncRNA promoters originated in retrotransposons suggesting their recent emergence...
January 13, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28087350/corrigendum-to-pregnancy-derived-from-human-zygote-pronuclear-transfer-in-a-patient-who-had-arrested-embryos-after-ivf-reproductive-biomedicine-online-33-2016-529-533
#19
John Zhang, Guanglun Zhuang, Yong Zeng, Jamie Grifo, Carlo Acosta, Yimin Shu, Hui Liu
No abstract text is available yet for this article.
January 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28081254/maternal-supply-of-cas9-to-zygotes-facilitates-the-efficient-generation-of-site-specific-mutant-mouse-models
#20
Alberto Cebrian-Serrano, Shijun Zha, Lars Hanssen, Daniel Biggs, Christopher Preece, Benjamin Davies
Genome manipulation in the mouse via microinjection of CRISPR/Cas9 site-specific nucleases has allowed the production time for genetically modified mouse models to be significantly reduced. Successful genome manipulation in the mouse has already been reported using Cas9 supplied by microinjection of a DNA construct, in vitro transcribed mRNA and recombinant protein. Recently the use of transgenic strains of mice overexpressing Cas9 has been shown to facilitate site-specific mutagenesis via maternal supply to zygotes and this route may provide an alternative to exogenous supply...
2017: PloS One
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