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https://www.readbyqxmd.com/read/29135610/meralgia-paresthetica-after-spine-surgery-on-the-jackson-table
#1
Nitin Agarwal, Jaydev B Mistry, Preeya V Khandge, David R Hansberry, Ira M Goldstein
Meralgia paresthetica is a non-life-threatening neurological disorder characterized by numbness, tingling, and burning pain over the anterolateral thigh due to impingement of the lateral femoral cutaneous nerve. This disorder has been seen in patients with diabetes mellitus and obesity, but has also been observed in patients after procedures such as posterior spine surgery, iliac crest bone grafts, lumbar disk surgery, hernia repair, appendectomies, and pelvic osteotomies that ultimately lead to compression or damage to the lateral femoral cutaneous nerve...
November 10, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29132064/patients-and-caregivers-contributions-for-differentiating-epileptic-from-psychogenic-nonepileptic-seizures-value-and-limitations-of-self-reporting-questionnaires-a-pilot-study
#2
Giuseppe Erba, Elisa Bianchi, Giorgia Giussani, John Langfitt, Adam Juersivich, Ettore Beghi
PURPOSE: Questionnaires investigating semiology and comorbidities of psychogenic non-epileptic seizures (PNES) have been used mainly to help physicians expedite referrals to epilepsy centres for confirmation of diagnosis rather than as alternative diagnostic tool when video-EEG monitoring (VEM), the current gold standard, is not available or is inconclusive. METHODS: We developed one structured questionnaire for patients, exploring subjective experiences and vulnerabilities and one for eyewitnesses, focused on features observable during typical events to study prospectively 50 consecutive adult patients with PNES or epileptic seizures (ES) admitted for VEM...
November 8, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29130548/reliability-and-validity-of-the-arabic-ptsd-checklist-civilian-version-pcl-c-in-women-survivors-of-intimate-partner-violence
#3
Eman Alhalal, Marilyn Ford-Gilboe, Carol Wong, Fadia AlBuhairan
Although intimate partner violence (IPV) survivors are at high risk for developing posttraumatic stress disorder (PTSD), PTSD has been considered a disorder specific to Western culture. There is a lack of reliable and valid measures of PTSD symptomology available in the Arab world, and there is still no clear evidence about the underlying factor structure of PTSD symptomology in the context of IPV. Thus, in the present study we investigated the construct validity (factor structure), internal consistency, and concurrent validity of a translated version of the PTSD Checklist Civilian Version (PCL-C) in a sample of 299 Saudi women who had experienced IPV...
November 11, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/29126536/a-53-year-old-man-with-a-bronchial-mass-and-multiple-bone-lesions
#4
Sujith V Cherian, Rosa M Estrada-Y-Martin, Shahreen Billah, Annikka Weissferdt
A 53-year-old man was admitted with complaints of back pain of 3 months' duration along with numbness and weakness in his left upper and lower extremities. He denied any respiratory complaints or anorexia but did report an 11 kg weight loss over the last 3 months. He had no other significant medical history and denied any history of cigarette smoking or recreational drug use. Family history was significant for prostate cancer in his father.
November 2017: Chest
https://www.readbyqxmd.com/read/29125903/a-loss-of-sensation
#5
Sarah L Patterson, Kashif Jafri, Jared A Narvid, Mary Margaretten
The patient was in her usual state of good health until one week prior to presentation when she developed low back pain and numbness and tingling around her abdomen and lower back. Over the next several hours the numbness spread distally to involve her legs and feet, and it became difficult to walk. The following day she developed constipation and urinary retention. This article is protected by copyright. All rights reserved.
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29125442/long-term-outcomes-after-surgical-treatment-of-pediatric-neurogenic-thoracic-outlet-syndrome
#6
Jennifer Hong, Jared M Pisapia, Zarina S Ali, Austin J Heuer, Erin Alexander, Gregory G Heuer, Eric L Zager
OBJECTIVE Neurogenic thoracic outlet syndrome (nTOS) is an uncommon compression syndrome of the brachial plexus that presents with pain, sensory changes, and motor weakness in the affected limb. The authors reviewed the clinical presentations and outcomes in their series of pediatric patients with surgically treated nTOS over a 6-year period. METHODS Cases of nTOS in patients age 18 years or younger were extracted for analysis from a prospective database of peripheral nerve operations. Baseline patient characteristics, imaging and neurophysiological data, operative findings, and outcomes and complications were assessed...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29122149/direct-and-indirect-effects-of-exercise-on-posttraumatic-stress-disorder-symptoms-a-longitudinal-study
#7
James W Whitworth, Lynette L Craft, Shira I Dunsiger, Joseph T Ciccolo
OBJECTIVE: Emerging evidence suggests that exercise may have beneficial effects on posttraumatic stress disorder (PTSD), and that this relationship may be indirectly affected by sleep, pain, and alcohol/substance use. The present study examined the longitudinal direct and indirect effects of exercise on PTSD symptoms. METHOD: A national sample of 182 individuals, screening positive for PTSD, completed online assessments of PTSD symptoms, exercise behavior, psychological distress, sleep quality, and alcohol/substance use at baseline and three-month follow-up...
November 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29121065/proteomic-analysis-reveals-novel-ligands-and-substrates-for-lnx1-e3-ubiquitin-ligase
#8
Joan A Lenihan, Orthis Saha, Paul W Young
Ligand of Numb protein X1 (LNX1) is an E3 ubiquitin ligase that contains a catalytic RING (Really Interesting New Gene) domain and four PDZ (PSD-95, DlgA, ZO-1) domains. LNX1 can ubiquitinate Numb, as well as a number of other ligands. However, the physiological relevance of these interactions in vivo remain unclear. To gain functional insights into the LNX family, we have characterised the LNX1 interactome using affinity purification and mass spectrometry. This approach identified a large number of novel LNX1-interacting proteins, as well as confirming known interactions with NUMB and ERC2...
2017: PloS One
https://www.readbyqxmd.com/read/29119724/evaluation-of-first-line-bismuth-containing-7-day-concomitant-quintuple-therapy-for-helicobacter-pylori-eradication
#9
Jianfang Ye, Junbo Hong, Yin Zhu, Yong Xie, Xu Shu, Lingyu Luo, Chuan Xie, Zhenhua Zhu, Nonghua Lu
BACKGROUND: Helicobacter pylori infection is difficult to cure, mainly due to antibiotic resistance. We performed a trial to determine the efficacy and safety of a bismuth-containing 7-day concomitant quintuple regimen for the eradication of H. pylori. METHODS: Conducted from August 2015 to February 2016 at First Affiliated Hospital of Nanchang University, this prospective trial enrolled 70 untreated H. pylori-positive patients. Patients received 7-day quintuple therapy consisting of bismuth subcitrate 220 mg, esomeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, and metronidazole 400 mg, each twice daily...
November 9, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29117836/compressive-ulnar-neuropathy-caused-by-olecranon-bursitis-and-concomitant-epidermal-cyst-a-case-report
#10
Hiroshi Yamazaki, Michitaka Shinone, Hiroyuki Kato
Epidermal cyst is a dermal or subcutaneous epithelial cyst that contains keratin and is lined by true epidermis. Although extremely rare, it can cause pathology including nerve compression syndrome. We report a rare case of ulnar nerve compression in the elbow that was caused by olecranon bursitis and concomitant epidermal cyst in a 67-year-old man. The ulnar nerve was immediately adjacent to the olecranon bursa and was significantly compressed. There was no connection between the tumor and the ulnar nerve...
December 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29117336/clinical-and-genetic-predictors-of-paclitaxel-neurotoxicity-based-on-patient-versus-clinician-reported-incidence-and-severity-of-neurotoxicity-in-the-icon7-trial
#11
S B Park, J B Kwok, R Asher, C K Lee, P Beale, F Selle, M Friedlander
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of paclitaxel, with no reliable method to identify at-risk patients. We investigated the incidence and risk factors including genetic polymorphisms associated with the development of CIPN based on clinician and patient reporting of neuropathic symptoms. Patients and methods: Risk factors for the development of CIPN were examined in 454 patients treated with paclitaxel/carboplatin from the International Collaboration on Ovarian Neoplasms 7 (ICON7) trial...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29117294/computer-assisted-planning-and-3d-printing-assisted-modeling-for-chin-augmentation
#12
Po-Chuan Chang
Background: Patients are frequently not satisfied with the outcome of chin augmentation. Objectives: We report the use of three-dimensional (3D) imaging and printing to design custom fit porous polyethylene chin implants. Methods: Patients requesting chin augmentation received 3D computed tomography (CT) imaging of the facial area. Patients could select the chin contour they desired by viewing 3D images of their face and chin. A 3D mandible replicate was printed from the CT data, and used to sculpt the inner surface of the implant to match the shape of the mandible, and the outer surface to match the contour the patient desired...
May 30, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29115587/anticancer-effect-of-quinacrine-on-diffuse-large-b%C3%A2-cell-lymphoma-via-inhibition-of-msi2%C3%A2-numb-signaling-pathway
#13
Shujun Yang, Lixia Sheng, Kaihong Xu, Yi Wang, Huiling Zhu, Ping Zhang, Qitian Mu, Guifang Ouyang
Diffuse large B‑cell lymphoma (DLBCL) is the most common subtype of non‑Hodgkin's lymphoma. Despite improvements in the clinical outcomes of DLBCL, ~30% of patients will develop relapse/refractory disease. Therefore, novel therapeutic drugs have been investigated to improve disease outcomes. Previous studies have revealed the anticancer effects of quinacrine (QC) on tumor cells in vitro, although its role in human DLBCL is yet to be identified. The present study sought to examine the cytotoxic effect of QC on DLBCL cells...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114317/agenesis-of-the-internal-carotid-artery-with-transcavernous-anastomosis-associated-with-anterior-communicating-artery-aneurysms
#14
Kosuke Kumagai, Satoru Takeuchi, Naoki Otani, Masaki Komiyama, Kentaro Mori
Agenesis of the internal carotid artery (ICA) is a rare congenital anomaly. Recently, several cases of ICA agenesis have been associated with cerebral aneurysms. We present the seventh case of ICA agenesis with transcavernous anastomosis associated with cerebral aneurysms. A 47-year-old man presented with transient numbness of his left hand. Magnetic resonance angiography indicated the presence of anterior communicating artery (ACoA) aneurysms. Digital subtraction angiography revealed two ACoA aneurysms, absence of the left ICA, and an anomalous collateral vessel connecting the cavernous portions of both internal carotid arteries, which was considered to be a transcavernous anastomosis...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29113155/poems-syndrome-presentation-with-progressive-weakness-in-upper-and-lower-limbs-a-case-report
#15
Chuang-Jie Cao, Cheng-Yun Dou, Ke-Hua Zhou, Jin-Bo Liu, Hong Lai
Polyneuropathy, organomegaly, endocrinopathy, M proteins, and skin changes (POEMS) syndrome is a rare variant of plasma cell disorders with multiple systemic manifestations. A 50-year-old female patient presented with progressive weakness in her upper and lower limbs; tingling, numbness and burning in her feet; polyneuropathy (demyelinating in the majority of cases of POEMS syndrome); monoclonal plasma cell disorder (typicallyλ-restricted in cases of POEMS syndrome); sclerotic lesions on the spine and pelvis; organomegaly, including hepatomegaly, splenomegaly and lymphadenopathy; edema; pleural effusion; adrenal, thyroidal, pituitary, gonadal and pancreatic endocrinopathy; skin changes, including hyperpigmentation, dry skin and hypertrichosis; thrombocytosis; pulmonary hypertension; low vitamin B12 and weight loss...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110188/percutaneous-balloon-compression-for-persistent-or-recurrent-trigeminal-neuralgia-after-microvascular-decompression-personal-experience-of-28-patients
#16
Wu Xu, Chengrong Jiang, Chen Yu, Weibang Liang
The objective of this study is to investigate the long-term effects of percutaneous balloon compression (PBC) for treating persistent or recurrent trigeminal neuralgia (TN) after microvascular decompression (MVD). The clinical features, surgical findings, outcomes, and complications of 28 patients underwent PBC for TN in Nanjing Drum Tower Hospital between April 2011 and March 2015 were analyzed retrospectively. All the patients had received MVD before but they did not get cured or the symptom relapsed during follow-up...
November 6, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29108922/use-of-erlotinib-and-thalidomide-in-advanced-nsclc-patients-with-acquired-resistance-to-erlotinib-a-pilot-study
#17
Gen-He Wang, Peng-Fei Wu, Long-Hui Zhang, Ping Fang, Yong Chen, Gang Zuo, Yi-Qing Wu, Shu-Hong Wang, Guo-Ping Sun
Evidences suggested that combined blockade of the VEGF and EGFR pathways can improve the treatment efficacy of non-small-cell lung cancer (NSCLC). In our previously clinical practice, we observed that thalidomide, a potent VEGF inhibitor, can significantly decrease the tumor size of one EGFR-TKI resistance patient with lung cancer cachexia. In this pilot study, we tried to assess the efficacy and toxicity of the combination therapy of erlotinib and thalidomide in advanced NSCLC patients with acquired resistance to erlotinib...
October 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29108784/clinical-outcomes-and-return-to-sport-in-competitive-athletes-undergoing-arthroscopic-iliopsoas-fractional-lengthening-compared-with-a-matched-control-group-without-iliopsoas-fractional-lengthening
#18
Itay Perets, David E Hartigan, Edwin O Chaharbakhshi, Lyall Ashberg, Brian Mu, Benjamin G Domb
PURPOSE: To compare the minimum 2-year outcomes and return to sports in competitive athletes after arthroscopic iliopsoas fractional lengthening (IFL) and treatment for femoroacetabular impingement (FAI) to competitive athletes treated for FAI who did not undergo IFL. METHODS: Data were prospectively collected and retrospectively reviewed between November 2009 and April 2014. Included patients were high school, collegiate, or professional athletes who underwent arthroscopic IFL, treatment for FAI, and preoperative modified Harris Hip Score, Non-Arthritic Athletic Hip Score, Hip Outcome Score-Sports Specific Subscale, and visual analog scale...
November 3, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29108667/clinical-electrophysiological-genetic-and-imaging-features-of-six-chinese-han-patients-with-hereditary-neuropathy-with-liability-to-pressure-palsies-hnpp
#19
Bin Chen, Songtao Niu, Xingao Wang, Wei Li, Na Chen, Zaiqiang Zhang
Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant peripheral neuropathy caused by mutations in the peripheral myelin protein 22 (PMP22) gene. This study summarizes the clinical, electrophysiological, genetic, and imaging features of six unrelated Chinese Han patients with HNPP. Age of onset was within the second decade in five patients, and 46 years of age in one patient. Weakness or numbness in a unilateral lower extremity was the most common symptom in 5 patients, and bilateral sensorineural hearing loss was also detected in one patient...
November 3, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29105774/motor-and-sensory-morbidity-associated-with-the-anterolateral-thigh-perforator-free-flap
#20
Christopher W Noel, Peter S Vosler, Michael Hong, Mario Orsini, Fayzullo Sultanov, Zihang Lu, Gian-Marco Busato, Danny Enepekides, Kevin Higgins
OBJECTIVE: To quantify changes in motor function, sensation, and lower extremity quality of life following anterior lateral thigh free flap (ALT) resection. METHODS: This mixed methods study contained both a prospective cohort arm (n = 20) and retrospective cross-sectional arm (n = 20). In both arms, patients underwent formal motor and sensation testing of the ipsilateral and contralateral thigh by sphygmomanometry and monofilament testing. In the prospective arm, data was collected preoperatively and at the 6-month and 1-year follow-up visits...
November 6, 2017: Laryngoscope
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