Annette T Hastie, Andrew C Bishop, Mohammad S Khan, Eugene R Bleecker, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Elliot Israel, Bruce D Levy, David T Mauger, Deborah A Meyers, Wendy C Moore, Victor E Ortega, Stephen P Peters, Sally E Wenzel, Chad H Steele
INTRODUCTION: Previous bronchoalveolar lavage fluid (BALF) proteomic analysis has evaluated limited numbers of subjects for only a few proteins of interest, which may differ between asthma and normal controls. Our objective was to examine a more comprehensive inflammatory biomarker panel in quantitative proteomic analysis for a large asthma cohort to identify molecular phenotypes distinguishing severe from nonsevere asthma. METHODS: Bronchoalveolar lavage fluid from 48 severe and 77 nonsevere adult asthma subjects were assessed for 75 inflammatory proteins, normalized to BALF total protein concentration...
January 22, 2024: Clinical and Experimental Allergy