keyword
https://read.qxmd.com/read/38350816/topical-application-of-activator-protein-1-inhibitor-t-5224-suppresses-inflammation-and-improves-skin-barrier-function-in-a-murine-atopic-dermatitis-like-dermatitis
#21
JOURNAL ARTICLE
Minori Sasakura, Hitoshi Urakami, Kota Tachibana, Kenta Ikeda, Ken-Ichi Hasui, Yoshihiro Matsuda, Ko Sunagawa, Daisuke Ennishi, Shuta Tomida, Shin Morizane
BACKGROUND: Selective activator protein (AP)-1 inhibitors are potentially promising therapeutic agents for atopic dermatitis (AD) because AP-1 is an important regulator of skin inflammation. However, few studies have investigated the effect of topical application of AP-1 inhibitors in treating inflammatory skin disorders. METHODS: Immunohistochemistry was conducted to detect phosphorylated AP-1/c-Jun expression of skin lesions in AD patients. In the in vivo study, 1 % T-5224 ointment was topically applied for 8 days to the ears of 2,4 dinitrofluorobenzene challenged AD-like dermatitis model mice...
February 12, 2024: Allergology International: Official Journal of the Japanese Society of Allergology
https://read.qxmd.com/read/38349864/gut-microbiota-was-highly-related-to-the-immune-status-in-chronic-obstructive-pulmonary-disease-patients
#22
JOURNAL ARTICLE
Mei Wang, Jun Song, Huizhen Yang, Xiaoyu Wu, Jin Zhang, Sheng Wang
This study aimed to explore the profile of gut microbiota and immunological state in COPD patients. 80 fecal and blood samples were collected from 40 COPD patients and 40 healthy controls (HC) and analyzed with 16s-rRNA gene sequencing and immunofactor omics analysis to investigate the profile of gut microbiota and immunologic factors (IFs). The linear discriminant analysis (LDA) effect size (LefSe) was used to determine the biomarker's taxa. The random forest and LASSO regression analysis were executed to screen IFs and develop an IFscore model...
February 12, 2024: Aging
https://read.qxmd.com/read/38345110/omicron-ba-4-5-neutralization-and-cell-mediated-immune-responses-in-relation-to-baseline-immune-status-and-breakthrough-infection-among-plwh-a-follow-up-cohort-study
#23
JOURNAL ARTICLE
Haoting Zhan, Yuchen Xie, Yongmei Liu, Linlin Cheng, Yi Xu, Xiaojing Qu, Chen Li, Xinru Guo, Haolong Li, Yuling Wang, Erhei Dai, Lijing Wang, Huixia Gao, Yongzhe Li
There is a paucity of data on hybrid immunity (vaccination plus breakthrough infection [BI]), especially cell-mediated responses to Omicron among immunosuppressed patients. We aim to investigate humoral and cellular responses to Omicron BA.4/5 among people living with HIV (PLWH) with/without BIs, the most prevalent variant of concern after the reopening of China. Based on our previous study, we enrolled 77 PLWH with baseline immune status of severe acute respiratory syndrome coronavirus 2 specific antibodies after inactivated vaccination...
February 2024: Journal of Medical Virology
https://read.qxmd.com/read/38341929/immunomodulatory-effect-of-lacticaseibacillus-casei-cb054-supplementation-in-calves-vaccinated-against-infectious-bovine-rhinotracheitis
#24
JOURNAL ARTICLE
Carolina Litchina Brasil, Vitória Sequeira Gonçalves, Francisco Denis Souza Santos, Paulo Ricardo Centeno Rodrigues, Fábio Pereira Leivas Leite, Daniela Isabel Brayer Pereira
Probiotics are live microorganisms that, confer health benefits to the host when supplemented in adequate amounts. They can promote immunomodulation by inducing phagocyte activity, leukocyte proliferation, antibody production, and cytokine expression. Lactic acid bacteria (BAL) are important probiotic specimens with properties that can improves ruminant nutrition, productivity and immunity. The aim of the present study was to evaluate the immunomodulatory effect of the supplementation with Lacticaseibacillus casei CB054 in calve vaccinated against bovine infectious rhinotracheitis (IBR)...
February 2, 2024: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/38340421/preconditioning-of-human-umbilical-cord-mesenchymal-stem-cells-with-deferoxamine-potentiates-the-capacity-of-the-secretome-released-from-the-cells-and-promotes-immunomodulation-and-beta-cell-regeneration-in-a-rat-model-of-type-1-diabetes
#25
JOURNAL ARTICLE
Basak Isildar, Serbay Ozkan, Hakan Sahin, Merve Ercin, Selda Gezginci-Oktayoglu, Meral Koyuturk
This study aimed to examine the effects of the secretome released by human umbilical cord-mesenchymal stem cells (MSC) as a result of preconditioning with deferoxamine (DFX), a hypoxia mimetic agent, on type 1 diabetes (T1D), by comparing it with the secretome produced by untreated MSCs. Initially, the levels of total protein, IL4, IL10, IL17, and IFNγ in the conditioned medium (CM) obtained from MSCs subjected to preconditioning with 150 µM DFX (DFX-CM) were analyzed in comparison to CM derived from untreated MSCs (N-CM)...
February 9, 2024: International Immunopharmacology
https://read.qxmd.com/read/38337282/preparation-of-polyimide-ionic-liquid-hybrid-membrane-for-co-2-ch-4-separation
#26
JOURNAL ARTICLE
Xiaoyu Du, Shijun Zhao, Yanqing Qu, Hongge Jia, Shuangping Xu, Mingyu Zhang, Guoliang Geng
Imidazole ionic liquids (ILs ) have good affinity and good solubility for carbon dioxide (CO2 ). Such ionic liquids, combined with polyimide membrane materials, can solve the problem that, today, CO2 is difficult to separate and recover. In this study, the ionic liquid (IL) of 1-ethyl-3-methylimidazolium tetrafluoroborate (IL1 ), 1-pentyl-3-methylimidazolium tetrafluoroborate (IL2 ), 1-octyl-3-methylimidazolium tetrafluoroborate (IL3 ), and 1-dodecylimidazolium tetrafluoroborate (IL4 ) with different contents were added to a polyimide matrix, and a series of polyimide membranes blended with ionic liquid were prepared using a high-speed mixer...
January 31, 2024: Polymers
https://read.qxmd.com/read/38336257/basophils-are-important-for-development-of-allergic-skin-inflammation
#27
JOURNAL ARTICLE
Juan-Manuel Leyva-Castillo, Daniela Vega-Mendoza, Maria Strakosha, Liwen Deng, Samantha Choi, Kensuke Miyake, Hajime Karasuyama, Isaac M Chiu, Wanda Phipatanakul, Raif S Geha
BACKGROUND: Atopic dermatitis skin lesions exhibit increased infiltration by basophils. Basophils produce IL-4, which plays an important role in the pathogenesis of atopic dermatitis. OBJECTIVE: We sought to determine the role of basophils in a mouse model of antigen-driven allergic skin inflammation. METHODS: Wild-type mice, mice with selective and inducible depletion of basophils, and mice expressing Il4-driven enhanced green fluorescent protein were subjected to epicutaneous sensitization with ovalbumin or saline...
February 7, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38327801/a-disrupted-foxp3-transcriptional-signature-underpins-systemic-regulatory-t%C3%A2-cell-insufficiency-in-early-pregnancy-failure
#28
JOURNAL ARTICLE
Lachlan M Moldenhauer, Kerrie L Foyle, Jasmine J Wilson, Ying Y Wong, David J Sharkey, Ella S Green, Simon C Barry, M Louise Hull, Sarah A Robertson
Regulatory T (Treg) cell defects are implicated in disorders of embryo implantation and placental development, but the origins of Treg cell dysfunction are unknown. Here, we comprehensively analyzed the phenotypes and transcriptional profile of peripheral blood Treg cells in individuals with early pregnancy failure (EPF). Compared to fertile subjects, EPF subjects had 32% fewer total Treg cells and 54% fewer CD45RA+ CCR7+ naive Treg cells among CD4+ T cells, an altered Treg cell phenotype with reduced transcription factor FOXP3 and suppressive marker CTLA4 expression, and lower Treg:Th1 and Treg:Th17 ratios...
February 16, 2024: IScience
https://read.qxmd.com/read/38322840/system-biology-approaches-to-identify-hub-genes-linked-with-ecm-organization-and-inflammatory-signaling-pathways-in-schizophrenia-pathogenesis
#29
JOURNAL ARTICLE
Piplu Bhuiyan, Zhaochu Sun, Md Arif Khan, Md Arju Hossain, Md Habibur Rahman, Yanning Qian
Schizophrenia (SZ) is a chronic and devastating mental illness that affects around 20 million individuals worldwide. Cognitive deficits and structural and functional changes of the brain, abnormalities of brain ECM components, chronic neuroinflammation, and devastating clinical manifestation during SZ are likely etiological factors shown by affected individuals. However, the pathophysiological events associated with multiple regulatory pathways involved in the brain of this complex disorder are still unclear...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38319611/combined-training-improves-gene-expression-related-to-immunosenescence-in-obese-type-2-diabetic-individuals
#30
JOURNAL ARTICLE
Diego T Brunelli, Ivan L P Bonfante, Vinicius O Boldrini, Pedro G Scolfaro, Renata G Duft, Keryma Mateus, Raphael F Fatori, Mara P T Chacon-Mikahil, Alessandro S Farias, Ana M Teixeira, Cláudia R Cavaglieri
Purpose: The aim of this study was to investigate the effects of moderate combined training (CT) on both the gene expression of pro- and anti-inflammatory markers and senescence in the immune system in peripheral blood mononuclear cells (PBMCs) and subcutaneous adipose tissue (SAT) of obese middle-aged individuals with type 2 diabetes (T2D). Methods: Thirty obese individuals (50.2 ± 9.4 years; body mass index: 31.8 ± 2.3 kg/m²) with T2D underwent 16 weeks of a CT group [CT; aerobic (50-60% of VO2max ) plus resistance (50-75% of 1RM) training; 3 times/week, 70 min/session; n = 16)] or a control group (CG, n = 14)...
February 6, 2024: Research Quarterly for Exercise and Sport
https://read.qxmd.com/read/38286436/stat6-tunes-maximum-t-cell-il-4-production-from-stochastically-regulated-il4-alleles
#31
JOURNAL ARTICLE
Ryan L Kyle, Melanie Prout, Graham Le Gros, Marcus J Robinson
T helper 2 (Th2) cells stochastically express from the Il4 locus but it has not been determined whether allelic expression is linked or independent. Here, we provide evidence that alleles are independently activated and inactivated. We compared Il4 locus expression in T cells from hemizygous IL-4 reporter mice in culture and in vivo following exposure to type 2 immunogens. In culture, Il4 alleles had independent, heritable expression probabilities. Modeling showed that in co-expressors, dual allele transcription occurs for only short periods, limiting per-cell mRNA variation in individual cells within a population of Th2 cells...
January 29, 2024: Immunology and Cell Biology
https://read.qxmd.com/read/38262391/sputum-transcriptomics-reveals-fcn1-macrophage-activation-in-mild-eosinophilic-asthma-compared-to-non-asthmatic-eosinophilic-bronchitis
#32
JOURNAL ARTICLE
Wenzhi Zhan, Wei Luo, Yulong Zhang, Keheng Xiang, Xiaomei Chen, Shuirong Shen, Chuqing Huang, Tingting Xu, Wenbin Ding, Yuehan Chen, Mingtong Lin, Xinghua Pan, Kefang Lai
PURPOSE: Eosinophilic asthma (EA) and non-asthmatic eosinophilic bronchitis (EB) share similar eosinophilic airway inflammation. Unlike EA, EB did not present airway hyperresponsiveness or airflow obstruction. We aimed to compare the mechanism underlying the different manifestations between EA and EB via sputum transcriptomics analysis. METHODS: Induced-sputum cells from newly physician-diagnosed EA, EB patients, and healthy controls (HCs) were collected for RNA sequencing...
January 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38253462/protein-protein-interactive-networks-identified-in-bronchoalveolar-lavage-of-severe-compared-to-nonsevere-asthma
#33
JOURNAL ARTICLE
Annette T Hastie, Andrew C Bishop, Mohammad S Khan, Eugene R Bleecker, Mario Castro, Loren C Denlinger, Serpil C Erzurum, John V Fahy, Elliot Israel, Bruce D Levy, David T Mauger, Deborah A Meyers, Wendy C Moore, Victor E Ortega, Stephen P Peters, Sally E Wenzel, Chad H Steele
INTRODUCTION: Previous bronchoalveolar lavage fluid (BALF) proteomic analysis has evaluated limited numbers of subjects for only a few proteins of interest, which may differ between asthma and normal controls. Our objective was to examine a more comprehensive inflammatory biomarker panel in quantitative proteomic analysis for a large asthma cohort to identify molecular phenotypes distinguishing severe from nonsevere asthma. METHODS: Bronchoalveolar lavage fluid from 48 severe and 77 nonsevere adult asthma subjects were assessed for 75 inflammatory proteins, normalized to BALF total protein concentration...
January 22, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38252127/post-polio-syndrome-is-not-a-dysimmune-condition
#34
JOURNAL ARTICLE
Isabelle Laffont, Claire Duflos, Christophe Hirtz, Karima Bakhti, Anthony Gelis, Claire Palayer, Valérie Macioce, Marion Soler, Fanny Pradalier, Florence Galtier, Alexandre Jentzer, Claire Lozano, Thierry Vincent, Raul J Morales
BACKGROUND: Poliomyelitis is a global disabling disease affecting 12-20 million of people. Post poliomyelitis syndrome (PPS) may affect up to 80% of polio survivors: increased muscle weakness, pain, fatigue, functional decline. It relies on aging of an impaired neuro-muscular system with ongoing denervation processes. A late involvement of humoral or cellular pro-inflammatory phenomena is also suspected. AIM: To assess the dysimmune hypothesis of PPS by comparing lymphocyte subpopulations and humoral immune factors between PPS patients and controls...
January 22, 2024: European Journal of Physical and Rehabilitation Medicine
https://read.qxmd.com/read/38245691/effects-of-calcium-supplementation-on-changes-in-the-il2-il4-il6-il10-axes-and-oxidative-stress-in-pregnant-women-at-risk-for-pre-eclampsia
#35
RANDOMIZED CONTROLLED TRIAL
Erica de Brito Pitilin, Filomena Marafon, Beatriz da Silva Rosa Bonadiman, Bruno Bordin Pelazza, Micheli Mainardi Pillat, Jéssica Dotto de Lara, Patrícia Pereira de Oliveira, Margarete Dulce Bagatini, Janine Schirmer
BACKGROUND: Pregnant women with hypertensive disorders are at increased risk for inflammatory diseases and oxidative stress. The dilemma raised by the best dosage of calcium supplementation on these factors is evident. The aim of the current study was to examine the effects of calcium on biomarkers of the purinergic system, inflammation and oxidative stress, which are factors contributing to vascular damage in pregnant women at high risk of pre-eclampsia. METHODS: A prospective, double-blind and placebo-controlled study conducted with 101 women at risk of pre-eclampsia were randomized to take 500 mg calcium/day or 1,500 mg calcium/day or placebo for 6 weeks from the 20th gestational week until delivery...
January 20, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38243672/anti-and-pro-inflammatory-milieu-differentially-regulate-differentiation-and-immune-functions-of-oligodendrocyte-progenitor-cells
#36
JOURNAL ARTICLE
Omri Zveik, Ariel Rechtman, Livnat Brill, Adi Vaknin-Dembinsky
Oligodendrocyte progenitor cells (OPCs) were regarded for years solely for their regenerative role; however, their immune-modulatory roles have gained much attention recently, particularly in the context of multiple sclerosis (MS). Despite extensive studies on OPCs, there are limited data elucidating the interactions between their intrinsic regenerative and immune functions, as well as their relationship with the inflamed central nervous system (CNS) environment, a key factor in MS pathology. We examined the effects of pro-inflammatory cytokines, represented by interferon (IFN)-γ and tumour necrosis factor (TNF)-α, as well as anti-inflammatory cytokines, represented by interleukin (IL)-4 and IL-10, on OPC differentiation and immune characteristics...
January 19, 2024: Immunology
https://read.qxmd.com/read/38241965/the-h3k9-demethylase-plant-homeodomain-finger-protein-2-regulates-interleukin-4-production-in-cd4-t-cells
#37
JOURNAL ARTICLE
Yuya Arakawa, Yuzuki Tano, Moe Fujii, Yuuki Imai, Yoshiaki Norimatsu, Masaki Yasukawa, Mikio Watanabe, Takeshi Yamada
CD4+ T cells play a key role in the immune response via their differentiation into various helper T cell subsets that produce characteristic cytokines. Epigenetic changes in CD4+ T cells are responsible for cytokine production in these subsets, although the exact molecular mechanisms remain unclear. Therefore, we investigated the effects of plant homeodomain finger protein 2 (PHF2), a histone H3K9 demethylase, on cytokine production in CD4+ T cells using T cell-specific Phf2-conditional knockout (cKO) mice in this study...
March 2024: Cytokine
https://read.qxmd.com/read/38238209/infections-in-the-era-of-immunobiologicals
#38
JOURNAL ARTICLE
Ricardo Romiti, André Luís da Silva Hirayama, Adriana Maria Porro, Heitor Sá Gonçalves, Luciane Donida Bartoli Miot, Sandra Maria Barbosa Durães, Silvio de Alencar Marques
Immunobiologicals represent an innovative therapeutic option in dermatology. They are indicated in severe and refractory cases of different diseases when there is contraindication, intolerance, or failure of conventional systemic therapy and in cases with significant impairment of patient quality of life. The main immunobiologicals used in dermatology basically include inhibitors of tumor necrosis factor-alpha (anti-TNF), inhibitors of interleukin-12 and -23 (anti-IL12/23), inhibitors of interleukin-17 and its receptor (anti-IL17), inhibitors of interleukin-23 (anti-IL23), rituximab (anti-CD20 antibody), dupilumab (anti-IL4/IL13) and intravenous immunoglobulin...
January 17, 2024: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38186164/-periodic-dynamic-observation-and-analysis-of-cellular-and-humoral-immunity-indexes-of-adults-infected-with-omicron-ba-1
#39
JOURNAL ARTICLE
M X Gao, Y Lei, L R Guo, J W Qu, H F Wang, X M Liu, R Li, M Kong, Z C Zhuang, Z L Tan, X Y Li, Y Zhang
Objective: To analyze the immunological characteristics and antibody changes of patients infected with the Omicron BA.1 and evaluate the possibility of secondary infection. Methods: A total of 104 patients infected with Omicron BA.1 in the Jinnan District of Tianjin from January 8 to February 2, 2022, were included in the study. The control group and case group were matched 1∶1 based on age, sex and vaccination status. Serum was collected from the case group and control group at 3, 6 and 9 months after infection...
December 6, 2023: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/38184171/m2a-macrophages-regulate-fibrosis-and-affect-the-outcome-after-stroke-via-pu-1-mtor-pathway-in-fibroblasts
#40
JOURNAL ARTICLE
Jiagui Huang, Yue Chen, Li Zhou, Jiangxia Ren, Mingfen Tian, Qinghuan Yang, Ling Wang, Youlin Wu, Jun Wen, Qin Yang
The moderate formation of the fibrotic scar plays an important role in functional recovery after stroke. M2a macrophages have been identified as an important source of early fibrosis after cerebral ischemia. However, the underlying mechanisms by which macrophages interact with fibroblasts in this context remain largely unknown. Therefore, our study aimed to further investigate the potential mechanisms underlying the effects of macrophages on fibroblasts following ischemic stroke. In vitro and in vivo, recombinant rat interleukin 4 (IL4) was used to induce macrophages to polarize into M2a macrophages...
January 4, 2024: Neurochemistry International
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