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https://www.readbyqxmd.com/read/29342151/cd8-signaling-in-microglia-macrophage-m1-polarization-in-a-rat-model-of-cerebral-ischemia
#1
Jan Boddaert, Kenny Bielen, Bart 's Jongers, Ekta Manocha, Laetitia Yperzeele, Patrick Cras, Daniel Pirici, Samir Kumar-Singh
Classical or M1 activity of microglia/macrophages has been described in several neurodegenerative and brain inflammatory conditions and has also been linked to expansion of ischemic injury in post-stroke brain. While different pathways of M1 polarization have been suggested to occur in the post-stroke brain, the precise underlying mechanisms remain undefined. Using a transient middle cerebral artery occlusion (MCAO) rat model, we showed a progressive M2 to M1 polarization in the perilesional brain region with M1 cells becoming one of the dominant subsets by day 4 post-stroke...
2018: PloS One
https://www.readbyqxmd.com/read/29337425/distinct-gene-expression-profiles-and-regulation-networks-of-nasal-polyps-in-eosinophilic-and-non-eosinophilic-chronic-rhinosinusitis
#2
Naoko Okada, Tsuguhisa Nakayama, Daiya Asaka, Natsuki Inoue, Tadao Tsurumoto, Shinya Takaishi, Nobuyoshi Otori, Hiromi Kojima, Akio Matsuda, Keisuke Oboki, Hirohisa Saito, Kenji Matsumoto, Mamoru Yoshikawa
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, is distinguished from other non-eosinophilic CRSwNP (NECRSwNP) types. However, the pathogenesis of each remains unclear. METHODS: Nasal polyp tissues from ECRS (ECRSwNP) and NECRS (NECRSwNP) patients were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis...
January 16, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29332250/the-levels-of-12-cytokines-and-growth-factors-in-tears-hyperthyreosis-vs-euthyreosis
#3
Jelena Juri Mandić, Ana Kozmar, Sanja Kusačić-Kuna, Anamarija Jazbec, Krešimir Mandić, Danijela Mrazovac, Nenad Vukojević
PURPOSE: Simultaneous analyses of the contents and ratios of 12 cytokines and growth factors in single samples of human tears were performed, and the results were compared between a group of healthy subjects and a group of patients with Graves' hyperthyreosis (GH) without thyroid-associated orbitopathy (TAO). METHODS: Determinations and concentration measurements of interleukins (IL-2, IL4, IL-6, IL-8, IL-10, IL-1α, and IL-1β) interferon (IFN-γ), tumor necrosis factor (TNF-α), monocyte chemoattractant protein (MCP-1), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) were performed with single tear samples from 21 patients with hyperthyreosis and 22 healthy subjects...
January 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29314322/association-between-pro-inflammatory-alleles-and-allergic-phenotypes-in-xhosa-adolescents
#4
Craig Laurence, Lize van der Merwe, Guicheng Zhang, Peter LeSouëf, Michael Levin
BACKGROUND: Significant differences exist in the prevalence, spectrum and severity of allergic diseases between developing and developed countries and between sub-populations within single countries. These discrepancies likely result from a complex interaction between genetic and environmental factors. However, the precise nature of the contribution of ethnicity to genetic differences in the predisposition to allergic disease is not yet fully understood. In particular, there is a paucity of literature regarding the genetic determinants of allergic disease in people of black African origin with little or no genetic admixture...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29311626/lipopolysaccharide-and-lipotheicoic-acid-differentially-modulate-epididymal-cytokine-and-chemokine-profiles-and-sperm-parameters-in-experimental-acute-epididymitis
#5
Erick J R Silva, Camilla M Ribeiro, André F M Mirim, Alan A S Silva, Renata M Romano, Jorge Hallak, Maria Christina W Avellar
Bacterial infections are the most prevalent etiological factors of epididymitis, a commonly diagnosed inflammatory disease in the investigation of male infertility factors. The influence of early pathogenic mechanisms at play during bacterial epididymitis on reproductive outcomes is little understood. We report here that experimental epididymitis induced in rats by Gram-negative (LPS) and Gram-positive (LTA) bacterial products resulted in differential patterns of acute inflammation in the cauda epididymis. LPS elicited a strong inflammatory reaction, as reflected by upregulation of levels of mRNA for seven inflammatory mediators (Il1b, Tnf, Il6, Ifng, Il10, Nos2 and Nfkbia), and tissue concentration of six cytokines/chemokines (IL1A, IL1B, IL6, IL10, CXCL2 and CCL2) within the first 24 h post-treatment...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29304389/the-expression-of-oxidative-stress-response-genes-is-modulated-by-a-combination-of-resveratrol-and-n-acetylcysteine-to-ameliorate-ototoxicity-in-the-rat-cochlea
#6
Fernando García-Alcántara, Silvia Murillo-Cuesta, Sara Pulido, Jose M Bermúdez-Muñoz, Raquel Martínez-Vega, Marta Milo, Isabel Varela-Nieto, Teresa Rivera
Aminoglycoside antibiotics are used widely in medicine despite their ototoxic side-effects. Oxidative stress and inflammation are key mechanisms determining the extent and severity of the damage. Here we evaluate the protective effect of a treatment with resveratrol plus N-acetylcysteine on the ototoxic actions of kanamycin and furosemide in the rat. Resveratrol (10 mg/kg) and N-acetylcysteine (400 mg/kg) were administered together to Wistar rats on 5 consecutive days. The second day, a concentrated solution of kanamycin and furosemide was placed on the round window to induce ototoxicity...
December 14, 2017: Hearing Research
https://www.readbyqxmd.com/read/29304229/cd16-macrophages-mediate-fibrosis-in-inflammatory-bowel-disease
#7
Pedro Salvador, Dulce Carolina Macías-Ceja, Laura Gisbert-Ferrándiz, Carlos Hernández, David Bernardo, Rafael Alós, Francisco Navarro-Vicente, Juan Vicente Esplugues, Dolores Ortiz-Masiá, Maria Dolores Barrachina, Sara Calatayud
Background and aims: Fibrosis is a common complication of Crohn's disease, and is related with dysregulated tissular repair following inflammation, in which macrophages play a central role. We have previously observed that STAT6-/- mice present delayed mucosal recovery after TNBS-induced colitis due to a deficiency in reparatory IL4/STAT6-dependent M2 macrophages, which can be reverted by the exogenous transfer of this cell type. In the present study we aimed to analyze the role of STAT6-dependent macrophages in intestinal fibrosis...
January 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29298992/germline-variants-in-il4-mgmt-and-akt1-are-associated-with-prostate-cancer-specific-mortality-an-analysis-of-12-082-prostate-cancer-cases
#8
L M FitzGerald, S Zhao, A Leonardson, M S Geybels, S Kolb, D W Lin, J L Wright, R Eeles, Z Kote-Jarai, K Govindasami, G G Giles, M C Southey, J Schleutker, T L Tammela, C Sipeky, K L Penney, M J Stampfer, H Gronberg, F Wiklund, P Stattin, J Hugosson, D M Karyadi, E A Ostrander, Z Feng, J L Stanford
BACKGROUND: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further replication evidence is needed. METHODS: Twenty-two previously identified PCSM-associated genetic variants were genotyped in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each cohort, Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals for risk of PCSM associated with each variant...
January 3, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29297752/il4-interleukin-4-induces-autophagy-in-b-cells-leading-to-exacerbated-asthma
#9
Fucan Xia, Changwen Deng, Yanyan Jiang, Yulan Qu, Jiewen Deng, Zhijian Cai, Yuanyuan Ding, Zhenhong Guo, Jianli Wang
Allergic asthma is a common airway inflammatory disease in which B cells play important roles through IgE production and antigen presentation. SNP (single nucleotide polymorphism) analysis showed that Atg (autophagy-related) allele mutations are involved in asthma. It has been demonstrated that macroautophagy/autophagy is essential for B cell survival, plasma cell differentiation and immunological memory maintenance. However, whether B cell autophagy participates in asthma pathogenesis remains to be investigated...
January 3, 2018: Autophagy
https://www.readbyqxmd.com/read/29288696/cytokine-gene-polymorphisms-in-iraqi-arabs
#10
Ali H Ad'hiah, Zahra'a A Ahmed, Milad A Al-Naseri, Ehab D Salman, Osama B Al-Saffar, Hiba S Ahmed, Talib A Hussain, Ekhlass M Idan, Ibtesam B Hassan, Batool A Shihab, Lateef O Mohammed, Fatima S Al-Nasiri
In this report, 224 unrelated healthy Iraqi Arabs (102 males and 122 females) were genotyped for 22 SNPs (single nucleotide polymorphisms) belong to 13 cytokine genes (IL1A, IL1B, IL1RA, IL1R, IL2, IL4, IL4R, IL6, IL10, IL12, IFNG, TNFA and TGFB1). The method of detection was PCR-SSP (polymerase chain reaction-sequence specific primer). The data were presented in terms of allele and genotype frequencies. Two-locus haplotype frequencies were also estimated for some SNPs. Genotype frequencies of detected cytokine gene polymorphisms are available in the Database of Allele Frequencies Net under the AFND number 3422 and the population name "Iraq Arab Cytokine"...
December 27, 2017: Human Immunology
https://www.readbyqxmd.com/read/29280610/immunomodulatory-ecm-like-microspheres-for-accelerated-bone-regeneration-in-diabetes-mellitus
#11
Zhiai Hu, Chi Ma, Xin Rong, Shujuan Zou, Xiaohua Liu
Bone repair and regeneration process is markedly impaired in diabetes mellitus (DM) that affects hundreds of millions of people worldwide. As a chronic inflammatory disease, DM creates a pro-inflammatory microenvironment in defective sites. Most of the studies on DM-associated bone regeneration, however, neglect the importance of immuno-modulation in the DM condition and adopt the same approaches to normal bone healing, leading to limited bone healing. In this study, we developed a unique bio-inspired injectable microsphere as an osteo-immunomodulatory biomaterial that modulates macrophages to create a pro-healing microenvironment in the DM condition...
December 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29273022/on-line-hemodiafiltration-did-not-induce-an-overproduction-of-oxidative-stress-and-inflammatory-cytokines-in-intensive-care-unit-acute-kidney-injury
#12
Kada Klouche, Laurent Amigues, Marion Morena, Vincent Brunot, Anne Marie Dupuy, Audrey Jaussent, Marie Christine Picot, Noémie Besnard, Delphine Daubin, Jean Paul Cristol
BACKGROUND: Though on-line intermittent hemodiafiltration (OL-IHDF) is a routine therapy for chronic dialysis patients, it is not yet widespread used in critically ill patients. This study was undergone to evaluate efficiency and tolerance of OL-IHDF and to appreciate inflammatory consequences of its use in intensive care unit (ICU)-acute kidney injury (AKI) patients. METHODS: In this prospective cohort study conducted in a medical academic ICU in France, 30 AKI patients who underwent OL-IHDF were included...
December 22, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29248573/bisphenol-a-exposure-induces-increased-microglia-and-microglial-related-factors-in-the-murine-embryonic-dorsal-telencephalon-and-hypothalamus
#13
Mifumi Takahashi, Munekazu Komada, Ken Miyazawa, Shigemi Goto, Yayoi Ikeda
Bisphenol A (BPA) is a widely used compound in the food packaging industry. Prenatal exposure to BPA induces histological abnormalities in the neocortex and hypothalamus in association with abnormal behaviors. Yet, the molecular and cellular neurodevelopmental toxicological mechanisms of BPA are incompletely characterized on neuroinflammatory-related endopoints. To evaluate the neurodevelopmental effects of BPA exposure in mouse embryos, we examined microglial numbers as well as the expression of microglial-related factors in the E15...
December 14, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29236307/interleukin-4-induces-a-cd44high-cd49bhigh-pc3-subpopulation-with-tumor-initiating-characteristics
#14
Holger H H Erb, Fabian Guggenberger, Frédéric R Santer, Zoran Culig
Pro- and anti-inflammatory cytokines may influence proliferation, migration, invasion and other cellular events of prostate cancer (PCa) cells. The hyaluronan receptor CD44, which is regulated by Interleukin (IL)-4, is a prostate basal cell marker. CD44high /CD49bhigh expressing cells have been demonstrated to have tumor-initiating characteristics. Here, we aimed to analyze the effects of long-term IL-4 treatment on CD44/CD49b expression, migration, proliferation and clonogenic potential of basal-like PCa cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29233972/irf8-dependent-molecular-complexes-control-the-th9-transcriptional-program
#15
Etienne Humblin, Marion Thibaudin, Fanny Chalmin, Valentin Derangère, Emeric Limagne, Corentin Richard, Richard A Flavell, Sandy Chevrier, Sylvain Ladoire, Hélène Berger, Romain Boidot, Lionel Apetoh, Frédérique Végran, François Ghiringhelli
Interferon regulatory factors (IRF) have critical functions in lymphoid development and in immune response regulation. Although many studies have described the function of IRF4 in CD4+ T cells, few have focused on the IRF4 homologue, IRF8. Here, we show that IRF8 is required for Th9 differentiation in vitro and in vivo. IRF8 functions through a transcription factor complex consisting of IRF8, IRF4, PU.1 and BATF, which binds to DNA and boosts Il9 transcription. By contrast, IRF8 deficiency promotes the expression of other genes such as Il4, as IRF8 dimerises with the transcriptional repressor ETV6 and inhibits Il4 expression...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29232822/microglia-m2a-polarization-as-potential-link-between-food-allergy-and-autism-spectrum-disorders
#16
REVIEW
Hans O Kalkman, Dominik Feuerbach
Atopic diseases are frequently co-morbid with autism spectrum disorders (ASD). Allergic responses are associated with an activation of mast cells, innate lymphoid cells, and Th2 cells. These cells produce type-2 cytokines (IL4 and IL13), which stimulate microglia and macrophages to adopt a phenotype referred to as 'alternative activation' or 'M2A'. M2A-polarized macrophages and microglia play a physiological role in tissue repair by secreting growth factors such as brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1...
December 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29205315/repository-corticotropin-injection-exerts-direct-acute-effects-on-human-b-cell-gene-expression-distinct-from-the-actions-of-glucocorticoids
#17
Ann L Benko, Carl A McAloose, Patrice M Becker, Dale Wright, Teresa Sunyer, Yuka Imamura Kawasawa, Nancy J Olsen, William J Kovacs
Repository corticotropin injection (RCI, H.P Acthar® Gel) has been approved for use in the management of multiple autoimmune and inflammatory diseases for over a half-century, but its mechanism of action is not well understood. We used RNA -Seq methods to define RCI-regulated mRNAs in cultured human B cells under conditions of activation by IL4 and CD40 ligand. Following IL4/CD40L activation and RCI treatment we found up-regulation of 115 unique mRNA transcripts and downregulation of 80 unique mRNAs. The effect on these RNA levels was dose-dependent for RCI and was distinct from changes in mRNA expression induced by treatment with a potent synthetic glucocorticoid...
December 4, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29191719/jak-stat-emerging-players-in-metabolism
#18
REVIEW
David W Dodington, Harsh R Desai, Minna Woo
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is crucial for transducing signals from a variety of metabolically relevant hormones and cytokines including growth hormone, leptin, erythropoietin, IL4, IL6 and IFNγ. A growing body of evidence suggests that this pathway is dysregulated in the context of obesity and metabolic disease. Recent development of animal models has been instrumental in identifying the role of JAK/STAT signaling in the peripheral metabolic organs including adipose, liver, muscle, pancreas, and the immune system...
November 27, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29188369/immune-modulation-of-th1-th2-and-t-reg-transcriptional-factors-differing-from-cytokine-levels-in-schistosoma-japonicum-infection
#19
Amel Farwa, Chao He, Longfei Xia, Hong Zhou
In spite of long-term integrated control programs for Schistosoma japonicum infection in China, the infection is still persistent due to its zoonotic transmission and disease severity which further complicate its control. Th1, Th2, and T-reg cells are involved in S. japonicum immunity; however, their exact roles in immunopathology of this infection are still questionable. Therefore, the monitoring of these T cell subsets' immune responses during a primary infection of S. japonicum at both transcriptional (mRNA) and protein (cytokines) levels would be essential to point out...
November 29, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29183288/arginase-1-deletion-in-myeloid-cells-affects-the-inflammatory-response-in-allergic-asthma-but-not-lung-mechanics-in-female-mice
#20
Roy H E Cloots, Selvakumari Sankaranarayanan, Matthew E Poynter, Els Terwindt, Paul van Dijk, Wouter H Lamers, S Eleonore Köhler
BACKGROUND: (Over-)expression of arginase may limit local availability of arginine for nitric oxide synthesis. We investigated the significance of arginase1 (ARG1) for the development of airway hyperresponsiveness (AHR) and lung inflammation in female mice with ovalbumin (OVA)-induced allergic asthma. METHODS: Arg1 was ablated in the lung by crossing Arg1 fl/fl and Tie2Cre tg/- mice. OVA sensitization and challenge were conducted, and AHR to methacholine was determined using the Flexivent system...
November 28, 2017: BMC Pulmonary Medicine
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