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https://www.readbyqxmd.com/read/28226398/dysregulation-of-interleukin-5-expression-in-familial-eosinophilia
#1
Senbagavalli Prakash Babu, Yun-Yun K Chen, Sandra Bonne-Annee, Jun Yang, Irina Maric, Timothy G Myers, Thomas B Nutman, Amy D Klion
BACKGROUND: Familial eosinophilia (FE) is a rare autosomal dominant inherited disorder characterized by the presence of lifelong peripheral eosinophilia (>1500/μL). Mapped to chromosome 5q31-q33, the genetic cause of FE is unknown, and prior studies have failed to demonstrate a primary abnormality in the eosinophil lineage. OBJECTIVE: The aim of the present study was to identify the cells driving the eosinophilia in FE. METHODS: Microarray analysis and real-time PCR were used to examine transcriptional differences in peripheral blood mononuclear cells (PBMC), and in purified cell subsets from affected and unaffected family members belonging to a single large kindred...
February 22, 2017: Allergy
https://www.readbyqxmd.com/read/28223726/dendritic-cells-engineered-to-secrete-anti-dcr3-antibody-augment-cytotoxic-t-lymphocyte-response-against-pancreatic-cancer-in-vitro
#2
Jiang Chen, Xiao-Zhong Guo, Hong-Yu Li, Jia-Jun Zhao, Wen-Da Xu
AIM: To investigate the enhanced cytotoxic T lymphocyte responses against pancreatic cancer (PC) in vitro induced by dendritic cells (DCs) engineered to secrete anti-DcR3 monoclonal antibody (mAb). METHODS: DCs, T lymphocytes and primary PC cells were obtained from PC patients. DCs were transfected with a designed humanized anti-DcR3 monoclonal antibody heavy and light chain mRNA and/or total tumor RNA (DC-tumor-anti-DcR3 RNA or DC-total tumor RNA) by using electroporation technology...
February 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28222797/melanoma-antigen-specific-effector-t-cell-cytokine-secretion-patterns-in-patients-treated-with-ipilimumab
#3
Yana G Najjar, Fei Ding, Yan Lin, Robert VanderWeele, Lisa H Butterfield, Ahmad A Tarhini
BACKGROUND: In a previously reported study, patients with regionally advanced melanoma were treated with neoadjuvant ipilimumab (ipi) (Tarhini in PLoS ONE 9(2): e87705, 3). Significant changes in circulating myeloid derived suppressor cells (MDSC), regulatory T cells (Treg) and peptide specific type I CD4(+) and CD8(+) T cells were noted at week 6 that correlated with clinical outcome. Characterization of antigen-specific effector T cell secreted cytokines may shed insights into ipi associated T cell activation and function...
February 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28215694/comparisons-of-the-humoral-and-cellular-immunity-induced-by-live-a16r-attenuated-spore-and-ava-like-anthrax-vaccine-in-mice
#4
Jin Lv, Ying-Ying Zhang, Xun Lu, Hao Zhang, Lin Wei, Jun Gao, Bin Hu, Wen-Wei Hu, Dun-Zhong Hu, Na Jia, Xin Feng
The live attenuated anthrax vaccine and anthrax vaccine adsorbed (AVA) are two main types of anthrax vaccines currently used in human. However, the immunoprotective mechanisms are not fully understood. In this study, we compared humoral and cellular immunity induced by live A16R spore vaccine and A16R strain derived AVA-like vaccine in mice peripheral blood, spleen and bone marrow. Both A16R spores and AVA-like vaccines induced a sustained IgG antibody response with IgG1/IgG2b subtype dominance. However, A16R spores vaccine induced higher titer of IgG2a compared with AVA-like vaccine, indicating a stronger Th1 response to A16R spores...
February 16, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28206989/il-4-mediated-by-hsv-vector-suppresses-morphine-withdrawal-response-through-decreasing-tnf%C3%AE-nr2b-and-pc-ebp%C3%AE-in-the-periaqueductal-gray-in-rats
#5
H Yi, T Iida, S Liu, D Ikegami, Q Liu, A Iida, D A Lubarsky, S Hao
Chronic opiates induce the development of physical dependence. Opioid physical dependence characterized by withdrawal symptoms, may have very long-lasting effects on the motivation for reward, including the incubation of cue-induced drug-seeking behavior. Elucidation of the mechanisms involved in physical dependence is crucial to developing more effective treatment strategies for opioid dependence. Chronic morphine induces production of proinflammatory cytokines in regional-specific sites of the brain. Interleukin-4 (IL-4) is a prototypical anti-inflammatory cytokine that globally suppresses proinflammatory cytokines...
February 16, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28179513/immune-responses-in-hibernating-little-brown-myotis-myotis-lucifugus-with-white-nose-syndrome
#6
T M Lilley, J M Prokkola, J S Johnson, E J Rogers, S Gronsky, A Kurta, D M Reeder, K A Field
White-nose syndrome (WNS) is a fungal disease responsible for decimating many bat populations in North America. Pseudogymnoascus destructans (Pd), the psychrophilic fungus responsible for WNS, prospers in the winter habitat of many hibernating bat species. The immune response that Pd elicits in bats is not yet fully understood; antibodies are produced in response to infection by Pd, but they may not be protective and indeed may be harmful. To understand how bats respond to infection during hibernation, we studied the effect of Pd inoculation on the survival and gene expression of captive hibernating Myotis lucifugus with varying pre-hibernation antifungal antibody titres...
February 8, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28176427/uterine-serpin-serpina-14-correlates-negatively-with-cytokine-production-at-the-foetal-maternal-interface-but-not-in-the-corpus-luteum-in-pregnant-dairy-heifers-experimentally-infected-with-neospora-caninum
#7
B Serrano-Pérez, S Almería, R Mur-Novales, I López-Helguera, I Garcia-Ispierto, J L Alabart, L Darwich, F López-Gatius
This study examines gene expression patterns in dairy heifers experimentally infected with N. caninum during on Day 110 of pregnancy with live foetuses at euthanasia, 42 days later. The study population was constituted of four non-infected controls and three infected dams. Gene expression was determined on gamma interferon (IFNγ), (Th1 pro-inflammatory cytokine), interleukin-4 (IL4) (Th2 pro-gestation cytokine) or interleukin-10 (IL10) (T regulatory cytokine) and the serine peptidase inhibitor SERPINA14 in intercaruncular, placental, uterine lymph node (UTLN) and luteal tissue samples...
February 7, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28173980/expression-of-polymeric-immunoglobulin-receptor-and-stromal-activity-in-pancreatic-ductal-adenocarcinoma
#8
Prabhu Arumugam, Satyajit Bhattacharya, Joanne Chin-Aleong, Melania Capaso, Hemant M Kocher
BACKGROUND/OBJECTIVES: Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work from our laboratory suggested pIgR may be upregulated in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the role of pIgR in human PDAC. METHODS: pIgR expression was manipulated (siRNA and shRNA) in cell lines to evaluate its subsequent effect on cell behaviour in 2D assays as well as 3D organotypics models...
February 1, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28161475/peripheral-inflammatory-cytokines-and-immune-balance-in-generalised-anxiety-disorder-case-controlled-study
#9
Ruihua Hou, Matthew Garner, Clive Holmes, Clive Osmond, Jessica Teeling, Laurie Lau, David S Baldwin
INTRODUCTION: Previous investigations have demonstrated that major depression is associated with particular patterns of cytokine signalling. The primary aim of this study was to examine peripheral pro-inflammatory and anti-inflammatory cytokines and immune balance in Generalised Anxiety Disorder (GAD). METHODS: A case-controlled cross-sectional study design was employed: 54 patients with GAD and 64 healthy controls were recruited. Participants completed self-report measures of anxiety and depression...
February 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28160073/genistein-improves-schistosomiasis-liver-granuloma-and-fibrosis-via-dampening-nf-kb-signaling-in-mice
#10
Chunpeng Wan, Fen Jin, Youqin Du, Kang Yang, Liangliang Yao, Zhigang Mei, Weifeng Huang
In schistosomiasis, egg deposition in the liver contributes to the formation of hepatic granuloma and fibrosis, which are the most serious clinical pathological features. It has been proposed that activation of the nuclear factor kappa B (NF-κB) signaling pathways is closely associated with the development of hepatic granuloma and fibrosis. Genistein has been shown to inhibit the activity of NF-κB signaling pathways, which might be a potential agent to protect against Schistosoma japonicum egg-induced liver granuloma and fibrosis...
February 3, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28159717/generation-of-anti-inflammatory-macrophages-for-implants-and-regenerative-medicine-using-self-standing-release-systems-with-a-phenotype-fixing-cytokine-cocktail-formulation
#11
Vladimir Riabov, Fabián Salazar, Su Su Htwe, Alexandru Gudima, Christina Schmuttermaier, Julien Barthes, Helena Knopf-Marques, Harald Klüter, Amir M Ghaemmaghami, Nihal Engin Vrana, Julia Kzhyshkowska
: The immediate tissue microenvironment of implanted biomedical devices and engineered tissues is highly influential on their long term fate and efficacy. The creation of a long-term anti-inflammatory microenvironment around implants and artificial tissues can facilitate their integration. Macrophages are highly plastic cells that define the tissue reactions on the implanted material. Local control of macrophage phenotype by long-term fixation of their healing activities and suppression of inflammatory reactions are required to improve implant acceptance...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28149185/promoter-polymorphism-590-t-c-of-interleukin-4-il4-gene-is-associated-with-rheumatoid-arthritis-an-updated-meta-analysis
#12
REVIEW
Hyun Kyung Park, Su Kang Kim, Hae Yong Kweon, Kwan Gill Lee, Mariadhas Valan Arasu, Young Ock Kim
Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) of IL4 gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) of IL4 gene is associated with the susceptibility of RA using meta-analysis. And in order to perform meta-analysis, comprehensive meta analysis program was used...
February 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28142034/association-of-il4-il13-and-il4r-polymorphisms-with-gastrointestinal-cancer-risk-a-meta-analysis
#13
Young Ae Cho, Jeongseon Kim
BACKGROUND: Previous studies have suggested that IL4, IL13, and IL4R are associated with serum IgE levels and allergies, and common variants of these genes may alter cancer risk. To clarify these associations, we conducted a meta-analysis to investigate the associations of IL4, IL13, and IL4R polymorphisms with gastrointestinal cancer risk. METHODS: We used 27 eligible case-control studies describing the associations of six polymorphisms of IL4, IL13, and IL4R with gastrointestinal cancer risk to calculate summary odds ratios (ORs) and 95% confidence intervals (CIs) using five different genetic models...
January 5, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28138512/aging-affects-bone-marrow-macrophage-polarization-relevance-to-bone-healing
#14
E Gibon, F Loi, Luis A Córdova, J Pajarinen, T Lin, L Lu, A Nabeshima, Z Yao, Stuart B Goodman
: Macrophages are an important component of the inflammatory cascade by initiating and modulating the processes leading to tissue regeneration and bone healing. Depending on the local environment, macrophages can be polarized into M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes. In order to assess the effects of aging on macrophage function, bone marrow macrophage polarization using primary bone marrow macrophages (BMMs) from young (8 weeks old) and aged (72 weeks old) wild-type male C57BL/6J mice was analyzed...
June 2016: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/28132936/rhs6-mediated-chromosomal-looping-and-nuclear-substructure-binding-is-required-for-th2-cytokine-gene-expression
#15
Soo Seok Hwang, Sung Woong Jang, Gap Ryol Lee
Subset-specific gene expression is a critical feature of CD4 T cell differentiation. Th2 cells express Th2 cytokine genes including Il4, Il5, and Il13 and mediate the immune response against helminths. The expression of Th2 cytokine genes is regulated by Rad50 hypersensitive site 6 (RHS6) in the Th2 locus control region; however, the molecular mechanisms of RHS6 action at the chromatin level are poorly understood. Here, we demonstrate that RHS6 is crucial for chromosomal interactions and nuclear substructure binding of the Th2 cytokine locus...
January 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28129666/non-invasive-proteome-analysis-of-psoriatic-stratum-corneum-reflects-pathophysiological-pathways-and-is-useful-for-drug-profiling
#16
B Méhul, G Laffet, A Séraïdaris, L Russo, P Fogel, I Carlavan, C Pernin, P Andres, C Queille-Roussel, J J Voegel
BACKGROUND: Protein expression is disturbed in psoriatic stratum corneum. Non-invasive methods for the description of pathophysiological changes and drug profiling in psoriasis are desirable. OBJECTIVES: Undertake large scale non-invasive protein expression studies in psoriatic stratum corneum to identify biomarkers of pathophysiological processes and use them for drug profiling. METHODS: Psoriatic stratum corneum was harvested through repetitive tape-stripping...
January 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28127976/galantamine-has-impact-on-immunity-in-mice-exposed-to-keyhole-limpet-hemocyanin
#17
M Pohanka, J Zakova, J Fusek
OBJECTIVES: In this work, we hypothesized whether galantamine could interact with the cholinergic anti-inflammatory pathway and modulate immunity this way. BACKGROUND: Galantamine is a drug used for the therapy of Alzheimer disease. The drug inhibits enzyme acetylcholinesterase in the central nervous system, which causes better availability of neurotransmitter acetylcholine. METHODS: In the experiment, we immunized BALB/c laboratory mice by keyhole limpet hemocyanin (KLH) in combination with galantamine in a dose 0...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28117434/genetic-polymorphisms-as-predictive-biomarker-of-survival-in-patients-with-gastrointestinal-stromal-tumors-treated-with-sunitinib
#18
J S L Kloth, M C Verboom, J J Swen, T van der Straaten, S Sleijfer, A K L Reyners, N Steeghs, H Gelderblom, H J Guchelaar, R H J Mathijssen
This study aimed to identify single-nucleotide polymorphisms (SNPs) that are associated with outcome to treatment with sunitinib in patients with advanced gastrointestinal stromal tumors (GIST). Forty-nine SNPS involved in the pharmacokinetic and pharmacodynamic pathway of sunitinib were associated with progression-free survival (PFS) and overall survival (OS) in 127 patients with advanced GIST who have been treated with sunitinib. PFS was significantly longer in carriers of the TT genotype in POR rs1056878 (hazards ratio (HR) 4...
January 24, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28117391/functional-ptgs2-polymorphism-based-models-as-novel-predictive-markers-in-metastatic-renal-cell-carcinoma-patients-receiving-first-line-sunitinib
#19
Arancha Cebrián, Teresa Gómez Del Pulgar, María José Méndez-Vidal, María Luisa Gonzálvez, Nuria Lainez, Daniel Castellano, Iciar García-Carbonero, Emilio Esteban, Maria Isabel Sáez, Rosa Villatoro, Cristina Suárez, Alfredo Carrato, Javier Munárriz-Ferrándiz, Laura Basterrechea, Mirta García-Alonso, José Luis González-Larriba, Begoña Perez-Valderrama, Josefina Cruz-Jurado, Aránzazu González Del Alba, Fernando Moreno, Gaspar Reynés, María Rodríguez-Remírez, Valentina Boni, Ignacio Mahillo-Fernández, Yolanda Martin, Andrea Viqueira, Jesús García-Foncillas
Sunitinib is the currently standard treatment for metastatic renal cell carcinoma (mRCC). Multiple candidate predictive biomarkers for sunitinib response have been evaluated but none of them has been implemented in the clinic yet. The aim of this study was to analyze single nucleotide polymorphisms (SNPs) in genes linked to mode of action of sunitinib and immune response as biomarkers for mRCC. This is a multicenter, prospective and observational study involving 20 hospitals. Seventy-five mRCC patients treated with sunitinib as first line were used to assess the impact of 63 SNPs in 31 candidate genes on clinical outcome...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115531/il-4-haploinsufficiency-specifically-impairs-ige-responses-against-allergens-in-mice
#20
Marcus J Robinson, Melanie Prout, Helen Mearns, Ryan Kyle, Mali Camberis, Elizabeth E Forbes-Blom, William E Paul, Christopher D C Allen, Graham Le Gros
Polymorphisms in genes involved in IL-4 responses segregate with allergic disease risk and correlate with IgE levels in humans, and IL-4 promotes IgE and IgG1 Ab production against allergens in mice. We report that mice with only one intact Il4 gene copy are significantly impaired in their ability to make specific IgE responses against allergens, whereas IgG1 responses to allergens remain unaffected. Il4-hemizygosity also resulted in a modest but detectable drop in IL-4 production by CD4(+) T cells isolated from lymph nodes and prevented IgE-dependent oral allergen-induced diarrhea...
January 23, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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