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https://www.readbyqxmd.com/read/28099424/the-establishment-of-cow-s-milk-protein-allergy-in-infants-is-related-with-a-deficit-of-regulatory-t-cells-treg-and-vitamin-d
#1
Laura Perezabad García, Jacobo López-Abente Muñoz, Elena Alonso-Lebrero, Elena Seoane Reula, Marjorie Pion, Rafael Correa-Rocha
BACKGROUND: Cow's milk protein allergy (CMPA) is the most common food allergy in infants. However, little is known about which specific immune mechanisms are related with the CMPA onset. The objective was to investigate which immune alterations constitute differential factors between allergy and tolerance, and hence could be implicated in the CMPA establishment in infants. METHODS: An extensive analysis of immune subsets, including Treg and cytokine-secreting cells was performed in blood samples from 28 infants younger than 9 months obtained 1-4 days after the first adverse reaction to milk...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28096407/development-of-chronic-allergic-responses-by-dampening-bcl6-mediated-suppressor-activity-in-memory-t-helper-2-cells
#2
Takashi Ogasawara, Masahiko Hatano, Hisae Satake, Jun Ikari, Toshibumi Taniguchi, Nobuhide Tsuruoka, Haruko Watanabe-Takano, Lisa Fujimura, Akemi Sakamoto, Hirokuni Hirata, Kumiya Sugiyama, Yasutsugu Fukushima, Susumu Nakae, Kenji Matsumoto, Hirohisa Saito, Takeshi Fukuda, Kazuhiro Kurasawa, Koichiro Tatsumi, Takeshi Tokuhisa, Masafumi Arima
Mice deficient in the transcriptional repressor B-cell CLL/lymphoma 6 (Bcl6) exhibit similar T helper 2 (TH2) immune responses as patients with allergic diseases. However, the molecular mechanisms underlying Bcl6-directed regulation of TH2 cytokine genes remain unclear. We identified multiple Bcl6/STAT binding sites (BSs) in TH2 cytokine gene loci. We found that Bcl6 is modestly associated with the BSs, and it had no significant effect on cytokine production in newly differentiated TH2 cells. Contrarily, in memory TH2 (mTH2) cells derived from adaptively transferred TH2 effectors, Bcl6 outcompeted STAT5 for binding to TH2 cytokine gene loci, particularly Interleukin4 (Il4) loci, and attenuated GATA binding protein 3 (GATA3) binding to highly conserved intron enhancer regions in mTH2 cells...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095306/the-role-of-pten-in-regulation-of-hepatic-macrophages-activation-and-function-in-progression-and-reversal-of-liver-fibrosis
#3
Yahui Cheng, Yuanyao Tian, Jialu Xia, Xiaoqin Wu, Yang Yang, Xiaofeng Li, Cheng Huang, Xiaoming Meng, Taotao Ma, Jun Li
Activation of Kupffer cells (KCs) plays a pivotal role in the pathogenesis of liver fibrosis. The progression and reversal of CCl4-induced mouse liver fibrosis showed a mixed induction of hepatic classical (M1) and alternative (M2) macrophage markers. Although the role of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in modulating myeloid cell activation has recently been identified, its function in macrophage activation during hepatic fibrosis remains to be fully appreciated. In our study, PTEN expression of KCs was remarkably decreased in CCl4-induced mice but increased to a near-normal level in reversed mice...
January 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28089639/a-systematic-review-of-the-association-between-fatigue-and-genetic-polymorphisms
#4
REVIEW
Tengteng Wang, Jie Yin, Andrew H Miller, Canhua Xiao
Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including single nucleotide polymorphisms (SNPs), especially in the regulatory regions, of relevant genes. To further investigate the association of SNPs with fatigue in various patient populations, a systematic search was conducted on Pubmed, CINAHL, PsycINFO, and Sociological Abstracts Database for fatigue related-terms in combination with polymorphisms or genetic variation-related terms...
January 12, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28059602/sumoylation-of-klf4-promotes-il-4-induced-macrophage-m2-polarization
#5
Kezhou Wang, Wei Zhou, Qi Cai, Jinke Cheng, Rong Cai, Rong Xing
Macrophages, in response to different environmental cues, undergo the classical polarization (M1 macrophages) as well as the alternative polarization (M2 macrophages) that involve the functions of stimulus-specific transcription factors. Kruppel-like factor 4 (KLF4), a member of a subfamily of the zinc-finger class of DNA-binding transcription factors, plays as a critical regulator of macrophage polarization. KLF4 has been reported as a SUMOylated protein. In this study, we showed that SUMOylation of KLF4, is induced by IL-4 treatment in macrophages...
January 6, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28056790/immunization-with-neural-derived-peptides-plus-scar-removal-induces-a-permissive-microenvironment-and-improves-locomotor-recovery-after-chronic-spinal-cord-injury
#6
Roxana Rodríguez-Barrera, Adrián Flores-Romero, Ana María Fernández-Presas, Elisa García-Vences, Raúl Silva-García, Mina Konigsberg, Liliana Blancas-Espinoza, Vinnitsa Buzoianu-Anguiano, Karla Soria-Zavala, Paola Suárez-Meade, Antonio Ibarra
BACKGROUND: Immunization with neural derived peptides (INDP) as well as scar removal-separately-have shown to induce morphological and functional improvement after spinal cord injury (SCI). In the present study, we compared the effect of INDP alone versus INDP with scar removal on motor recovery, regeneration-associated and cytokine gene expression, and axonal regeneration after chronic SCI. Scar removal was conducted through a single incision with a double-bladed scalpel along the stump, and scar renewal was halted by adding α,α'-dipyridyl...
January 5, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28054352/impact-of-il13-genetic-polymorphism-arg130gln-on-total-serum-ige-levels-and-ifn-%C3%AE-gene-expression
#7
Bozena Smolkova, Jana Tulinska, Lubica Palkovicova Murinova, Verona Buocikova, Aurelia Liskova, Katarina Rausova, Miroslava Kuricova, Henrieta Patayova, Maria Sustrova, Eva Neubauerova Svorcova, Silvia Ilavska, Michaela Szabova, Tomas Nemessanyi, Eva Jahnova, Maria Dusinska, Peter Ciznar, Laurence Fuortes
This cross-sectional study was designed to investigate the extent of genetic susceptibility by targeting variants in IL-4/IL-13 signalling pathways leading to atopic disease in early childhood. We evaluated involvement of five single nucleotide polymorphisms IL4 C-590T, IL13 C-1055T, IL13 Arg130Gln, IL4RA Ile50Val and IL4RA Ser478Pro, in the control of serum total and antigen-specific IgE levels. Furthermore, we analyzed their association with changes in gene expression of five cytokines having key roles in inflammatory and anti-inflammatory immune response (IL-4, IL-13, IFN-γ, IL-8 and IL-10)...
January 5, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28053321/functionality-and-opposite-roles-of-two-interleukin-4-haplotypes-in-immune-cells
#8
G Anovazzi, M C Medeiros, S C Pigossi, L S Finoti, T M Souza Moreira, M P A Mayer, C F Zanelli, S R Valentini, C Rossa-Junior, R M Scarel-Caminaga
Cytokines expression can be influenced by polymorphisms in their respective coding genes. We associated the CTI/TTD haplotype (Hap-1) and TCI/CCI haplotype (Hap-2) in the IL4 gene formed by the -590, +33 and variable number of tandem repeat polymorphisms with the severity of chronic periodontitis in humans. The functionality of these IL4 haplotypes in the response of immune cells to phorbol 12-myristate 13-acetate (PMA) with Ionomycin and IL-1β (as inflammatory stimuli) was evaluated. Gene expression (quantitative real-time PCR), profile of secreted cytokines (multiplex) and phenotypic polarization of T cells (flow cytometry) were the outcomes assessed...
January 5, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28045927/synbiotics-for-broiler-chickens-in-vitro-design-and-evaluation-of-the-influence-on-host-and-selected-microbiota-populations-following-in-ovo-delivery
#9
Aleksandra Dunislawska, Anna Slawinska, Katarzyna Stadnicka, Marek Bednarczyk, Piotr Gulewicz, Damian Jozefiak, Maria Siwek
Synbiotics are synergistic combinations of prebiotics and probiotics. In chickens, synbiotics can be delivered in ovo to expedite colonization of the gut by beneficial bacteria. We therefore aimed to design synbiotics in vitro and validate them in broiler chickens upon in ovo delivery. The probiotic components of the synbiotics were Lactobacillus salivarius and Lactobacillus plantarum. Their growth was assessed in MRS medium supplemented with different prebiotics. Based on in vitro results (hatchability and growth curve), two synbiotics were designed: S1 -Lactobacillus salivarius with galactooligosaccarides (GOS) and S2 -Lactobacillus plantarum with raffinose family oligosaccharides (RFO)...
2017: PloS One
https://www.readbyqxmd.com/read/28008464/long-term-effects-of-the-collagenase-of-the-bacterium-clostridium-histolyticum-for-the-treatment-of-capsular-fibrosis-after-silicone-implants
#10
Sebastian Fischer, Yannick Diehm, Thomas Henzler, Martin R Berger, Jonas Kolbenschlag, Anne Latz, Ericka M Bueno, Christoph Hirche, Ulrich Kneser, Bohdan Pomahac
BACKGROUND: Capsular contracture remains the most frequent long-term complication after augmentation mammoplasty with silicone implants. Thereby, the main part of the fibrotic capsule is collagen. The collagenase of the bacterium Clostridium histolyticum is approved for the treatment of fibrotic diseases and has been demonstrated to be effective for capsular fibrosis treatment in the short term. However, long-term effectiveness is currently unknown but mandatory for clinical utilization...
December 23, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28007592/colostrum-proinflammatory-cytokines-as-biomarkers-of-bovine-immune-response-to-bovine-tuberculosis-btb
#11
Eduardo Sánchez-Soto, Rosa Ponce-Ramos, Rodolfo Hernández-Gutiérrez, Abel Gutiérrez-Ortega, Angel H Álvarez, Moisés Martínez-Velázquez, Angel E Absalón, Pablo Ortiz-Lazareno, Alberto Limón-Flores, Ciro Estrada-Chávez, Sara E Herrera-Rodríguez
Bovine colostrum contains compounds, which provide passive immune protection from mother to newborn calves. Little is known about cytokine levels and their role in bovine colostrum. Moreover, the capacity of bovine colostrum cells to mount specific immune responses after natural exposure to bovine tuberculosis (bTB) antigens in dairy herds has not been studied, thus far. The purpose of this study was to identify biomarkers for bTB infection measurable in bovine colostrum. The present study reveals that isolated-immune colostrum cells can mount a specific immune response against bTB antigens, by measuring the novo IFN-γ release in cell culture...
December 19, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28006890/serum-cytokines-in-paediatric-neuropsychiatric-syndromes-focus-on-attention-deficit-hyperactivity-disorder
#12
Renato Donfrancesco, Paola Nativio, Edoardo Borrelli, Eleonora Giua, Elda Andriola, Maria P Villa, Michela DI Trani
BACKGROUND: Inflammation may represent a common underlying mechanism in a wide range of diseases, including neuropsychiatric disorders. Cytokine involvement has been investigated in some studies on patients with childhood neuropsychiatric diseases. The aim of this study was to determine whether cytokines are involved in ADHD to provide a rationale for immune-based therapeutic strategies in this disorder. METHODS: Sixty children were studied: 34 consecutive drug-naïve children with ADHD (30 males and 4 females; mean age of 10...
December 22, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27996163/study-of-il4-590c-t-and-il6-174g-c-gene-polymorphisms-in-type2-diabetic-patients-with-chronic-kidney-disease-in-north-indian-population
#13
Km Neelofar, Jamal Ahmad, Arif Ahmad, Khursheed Alam
BACKGROUND: To explore the associations between potential functional promoter polymorphisms in pro-inflammatory and anti-inflammatory (IL-4(-590C/T) and IL-6(-174G/C) cytokine genes and kidney dysfunction in north Indian type2 diabetic subjects with chronic kidney disease. METHODS: A total of 150 subjects aged 25-75 year were included in this study. The glomerular filtration rate (GFR) and serum creatinine were estimated. PCR was performed to analyse genotype distribution in IL-4 (-590T/C) and IL-6 (-174G/C) among healthy, type2 diabetic patients with or without CKD...
December 20, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27995420/lactic-acid-in-tumor-microenvironments-causes-dysfunction-of-nkt-cells-by-interfering-with-mtor-signaling
#14
Di Xie, Shasha Zhu, Li Bai
Cellular metabolism has been shown to regulate differentiation and function of immune cells. Tumor associated immune cells undergo phenotypic and functional alterations due to the change of cellular metabolism in tumor microenvironments. NKT cells are good candidates for immunotherapies against tumors and have been used in several clinical trials. However, the influences of tumor microenvironments on NKT cell functions remain unclear. In our studies, lactic acid in tumor microenvironments inhibited IFNγ and IL4 productions from NKT cells, and more profound influence on IFNγ was observed...
December 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27994210/mycobacterium-vaccae-induces-a-strong-th1-response-that-subsequently-declines-in-c57bl-6-mice
#15
Lijiao Zhang, Yanlong Jiang, Ziyin Cui, Wentao Yang, Limin Yue, Yingcong Ma, Shaohua Shi, Chunfang Wang, Chunfeng Wang, Aidong Qian
Mycobacterium (M.) vaccae is a fast-growing species of saprophytic bacteria that is widely distributed. To understand the host immune responses induced by M. vaccae isolated from bovine submaxillary lymph nodes, C57BL/6 mice were infected with reference strain M. bovis Bacillus Calmette-Guérin (BCG) and isolated M. vaccae using intraperitoneal injections. Comparison of the bacterial replication and organ pathology between M. vaccae and M. bovis BCG revealed that M. vaccae was more malignant than M. bovis in mice...
December 30, 2016: Journal of Veterinary Science
https://www.readbyqxmd.com/read/27992487/changes-in-host-cytokine-patterns-of-tb-patients-with-different-bacterial-loads-detected-using-16s-rrna-analysis
#16
Rhiannon Heslop, Adama L Bojang, Sheikh Jarju, Joseph Mendy, Sarah Mulwa, Ousman Secka, Francis S Mendy, Olumuyiwa Owolabi, Beate Kampmann, Jayne S Sutherland
BACKGROUND: Tuberculosis (TB) has overtaken HIV as the biggest infectious disease killer, with the majority of deaths occurring in sub-Saharan Africa. However it is unknown how differences in bacterial load alter host immune profiles in the sputum and blood of TB patients. METHODS: 16S ribosomal RNA analysis was used to determine bacterial load in sputum samples obtained from 173 patients with active TB (57 pre-treatment and 116 post-treatment). Host analyte concentrations in sputum and Mycobacterium tuberculosis (Mtb) antigen stimulated whole blood assay supernatants were analysed using multiplex cytokine arrays...
2016: PloS One
https://www.readbyqxmd.com/read/27964715/differential-effects-of-palmitoleic-acid-on-human-lymphocyte-proliferation-and-function
#17
M E P Passos, H H O Alves, C M Momesso, F G Faria, G Murata, M F Cury-Boaventura, E Hatanaka, S Massao-Hirabara, R Gorjão
BACKGROUND: Palmitoleic acid (PA) is a n-7 monounsaturated fatty acid (MUFA) secreted by adipose tissue and related to decreased insulin resistance in peripheral tissues. Evidences have been shown that PA also decreased proinflammatory cytokine expression in cultured macrophages. Although studies have shown that other fatty acids (FAs) modulate several lymphocyte functions, the specific effect of PA on these cells is unknown. The aim of the present study was to evaluate the possible influence of PA on activation and differentiation of human lymphocytes in comparison to oleic acid (OA)...
December 13, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27956797/ex-vivo-response-to-mucosal-bacteria-and-muramyl-dipeptide-in-inflammatory-bowel-disease
#18
Claudia Loganes, Erica Valencic, Alessia Pin, Elisa Marini, Stefano Martelossi, Samuele Naviglio, Luigina De Leo, Tarcisio Not, Lorenzo Monasta, Alberto Tommasini, Annalisa Marcuzzi
AIM: To evaluate how mucosal bacteria impact on the spontaneous and muramyl dipeptide (MDP)-induced inflammation in Crohn's disease (CD) and ulcerative colitis (UC). METHODS: Colonic mucosal biopsies were collected from children with active or remissive CD, UC and controls. Two tissue samples were taken from inflamed mucosal segments (in patients with active disease) or from non-inflamed mucosa [in patients in remission or in healthy controls (HC)]. Experiments were performed in the presence or absence of antibiotics, to assess whether the disease-associated microbiota can modulate the cytokine response ex vivo...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27939488/first-and-second-trimester-immune-biomarkers-in-preeclamptic-and-normotensive-women
#19
Brandie D Taylor, Roberta B Ness, Mark A Klebanoff, Roger Zoh, Debra Bass, David M Hougaard, Kristin Skogstrand, Catherine L Haggerty
INTRODUCTION: Circulating immune markers may be associated with preeclampsia but further investigations in early pregnancy and among preeclampsia subtypes are warranted. We examined immune markers in 208 preeclamptic women and 411 normotensive controls. METHODS: Our study was nested within the Collaborative Perinatal Project. A total of 242 women had first trimester serum samples and 392 had second trimester serum samples. Preeclampsia was defined as hypertension >20weeks of gestation with proteinuria or pulmonary edema, oliguria, or convulsions...
October 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27934903/unlocking-bat-immunology-establishment-of-pteropus-alecto-bone-marrow-derived-dendritic-cells-and-macrophages
#20
Peng Zhou, Yok Teng Chionh, Sergio Erdal Irac, Matae Ahn, Justin Han Jia Ng, Even Fossum, Bjarne Bogen, Florent Ginhoux, Aaron T Irving, Charles-Antoine Dutertre, Lin-Fa Wang
Bats carry and shed many emerging infectious disease agents including Ebola virus and SARS-like Coronaviruses, yet they rarely display clinical symptoms of infection. Bat epithelial or fibroblast cell lines were previously established to study the bat immune response against viral infection. However, the lack of professional immune cells such as dendritic cells (DC) and macrophages has greatly limited the significance of current investigations. Using Pteropus alecto (P. alecto) GM-CSF plus IL4, FLT3L and CSF-1, we successfully generated bat bone marrow-derived DC and macrophages...
December 9, 2016: Scientific Reports
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