keyword
MENU ▼
Read by QxMD icon Read
search

Il4

keyword
https://www.readbyqxmd.com/read/29778778/swimming-improves-cognitive-reserve-in-ovariectomized-rats-and-enhances-neuroprotection-after-global-cerebral-ischemia
#1
Meng Zhang, Yating Zhai, Yaping Sun, Wenli Zhang, Qian Li, Darrell Brann, Ruimin Wang
Cognitive reserve has been proposed to account for different responses to brain damage or pathology. Factors implicated to influence cognitive reserve include cognitive engagement, physical activity, leisure activities, stress levels, and diet. Furthermore, long-term ovariectomy (OVX), such as occurs in women that have underwent surgical menopause, has been reported to increase the risk of cognitive impairment. In the current study, we examined whether swimming improves cognitive function in long-term OVX-rats...
May 17, 2018: Brain Research
https://www.readbyqxmd.com/read/29776612/immunohistochemical-investigation-of-the-cross-reactivity-of-selected-cell-markers-in-formalin-fixed-paraffin-embedded-lymphoid-tissues-of-franciscana-pontoporia-blainvillei
#2
J Díaz-Delgado, R Ressio, K R Groch, J L Catão-Dias
A considerable amount of knowledge on natural and anthropogenic pathologic conditions affecting different cetacean species has been gained over the last decades. Nonetheless, the immunopathological bases for most of these processes have been poorly documented or remain unknown. Comparative immunopathological investigations in these species are precluded by the limited number of specific antibodies, most of which are not commercially available, and the reduced spectrum of validated and/or cross-reactive ones...
June 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29775732/il4-10-fusion-protein-has-chondroprotective-anti-inflammatory-and-potentially-analgesic-effects-in-the-treatment-of-osteoarthritis
#3
C Steen-Louws, J Popov-Celeketic, S C Mastbergen, K Coeleveld, C E Hack, N Eijkelkamp, M Tryfonidou, S Spruijt, J A G van Roon, F P J G Lafeber
OBJECTIVE: Effective disease-modifying drugs for osteoarthritis (DMOAD) should preferably have chondroprotective, anti-inflammatory, and analgesic activity combined in a single molecule. We developed a fusion protein of IL4 and IL10 (IL4-10 FP), in which the biological activity of both cytokines is preserved. The present study evaluates the chondroprotective, anti-inflammatory, and analgesic activity of IL4-10 FP in in vitro and in vivo models of osteoarthritis. METHODS: Human osteoarthritic cartilage tissue and synovial tissue were cultured with IL4-10 FP...
May 15, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29775023/-the-role-of-th1-th2-cells-imbalance-in-the-pathogenesis-of-secretory-otitis-media
#4
Z H Li, Q Y Fu, Z Y Li, K X Wang, Y C Xu, J P Xue
Objective: The aim of this study is to explore the role of Th1/Th2 cells imbalance in the pathogenesis of secretory otitis media. Method: Ninety secretory otitis media patients were enrolled in observation group. According to medical history, they were divided into acute and chronic group. In addition, 90 healthy volunteers during the same period were selected as the control group. The levels of Th1-type cytokines IFN-γ, Th2-type cytokines interleukin-4 (IL-4) and IFN-γ/IL-4 in peripheral blood were compared between observation group and control group...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770133/peripheral-blood-stem-cell-mobilization-in-healthy-donors-by-granulocyte-colony-stimulating-factor-causes-preferential-mobilization-of-lymphocyte-subsets
#5
Guro Kristin Melve, Elisabeth Ersvaer, Geir Egil Eide, Einar K Kristoffersen, Øystein Bruserud
Background: Allogeneic hematopoietic stem cell transplantation is associated with a high risk of immune-mediated post-transplant complications. Graft depletion of immunocompetent cell subsets is regarded as a possible strategy to reduce this risk without reducing antileukemic immune reactivity. Study design and methods: We investigated the effect of hematopoietic stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) on peripheral blood and stem cell graft levels of various T, B, and NK cell subsets in healthy donors...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29761786/association-of-a-four-locus-gene-model-including-il13-il4-fcer1b-and-adrb2-with-the-asthma-predictive-index-and-atopy-in-chinese-han-children
#6
S Bai, L Hua, X Wang, Q Liu, Y Bao
BACKGROUND AND OBJECTIVE: Asthma is a complex and heterogeneous disease. We found that gene-gene interactions among IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 in asthmatic children of Chinese Han nationality. This four-locus set constituted an optimal statistical interaction model. Objective: This study examined associations of the four-gene model consisting of IL13, IL4, FCER1B, and ADRB2 with the Asthma Predictive Index (API) and atopy in Chinese Han children...
May 11, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29747685/car-t-cell-therapy-for-breast-cancer-harnessing-the-tumor-milieu-to-drive-t-cell-activation
#7
Pradip Bajgain, Supannikar Tawinwung, Lindsey D'Elia, Sujita Sukumaran, Norihiro Watanabe, Valentina Hoyos, Premal Lulla, Malcolm K Brenner, Ann M Leen, Juan F Vera
BACKGROUND: The adoptive transfer of T cells redirected to tumor via chimeric antigen receptors (CARs) has produced clinical benefits for the treatment of hematologic diseases. To extend this approach to breast cancer, we generated CAR T cells directed against mucin1 (MUC1), an aberrantly glycosylated neoantigen that is overexpressed by malignant cells and whose expression has been correlated with poor prognosis. Furthermore, to protect our tumor-targeted cells from the elevated levels of immune-inhibitory cytokines present in the tumor milieu, we co-expressed an inverted cytokine receptor linking the IL4 receptor exodomain with the IL7 receptor endodomain (4/7ICR) in order to transform the suppressive IL4 signal into one that would enhance the anti-tumor effects of our CAR T cells at the tumor site...
May 10, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29747070/salmon-louse-rhabdoviruses-impact-on-louse-development-and-transcription-of-selected-atlantic-salmon-immune-genes
#8
Aina-Cathrine Øvergård, Lars Are Hamre, Sindre Grotmol, Frank Nilsen
Recently, it has been shown that the salmon louse (Lepeophtheirus salmonis) is commonly infected by one or two vertically transmitted Lepeophtheirus salmonis rhabdoviruses (LsRVs). As shown in the present study, the viruses have limited effect on louse survival, developmental rate and fecundity. Since the LsRVs were confirmed to be present in the louse salivary glands, the salmon cutaneous immune response towards LsRV positive and negative lice was analyzed. In general, L. salmonis increased the expression of IL1β, IL8 and IL4/13A at the attachment site, in addition to the non-specific cytotoxic cell receptor protein 1 (NCCRP-1)...
April 30, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29721374/ppar%C3%AE-activation-increases-intestinal-m1-macrophages-and-mitigates-formation-of-serrated-adenomas-in-mutant-kras-mice
#9
Tobias Gutting, Christian A Weber, Philip Weidner, Frank Herweck, Sarah Henn, Teresa Friedrich, Shuiping Yin, Julia Kzhyshkowska, Timo Gaiser, Klaus-Peter Janssen, Wolfgang Reindl, Matthias P A Ebert, Elke Burgermeister
To identify novel hubs for cancer immunotherapy, we generated C57BL/6 J mice with concomitant deletion of the drugable transcription factor PPARγ and transgenic overexpression of the mutant KRASG12V oncogene in enterocytes. Animals developed epithelial hyperplasia, transmural inflammation and serrated adenomas in the small intestine with infiltration of CD3+ FOXP3+ T-cells and macrophages into the lamina propria of the non-malignant mucosa. Within serrated polyps, CD3+ CD8+ T-cells and phosphorylated ERK1/2 were reduced and the senescence marker P21 and macrophage counts up-regulated, indicative of an immunosuppressive tissue microenvironment...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29721184/correlation-between-lower-balance-of-th2-helper-t-cells-and-expression-of-pd-l1-pd-1-axis-genes-enables-prognostic-prediction-in-patients-with-glioblastoma
#10
Yasuo Takashima, Atsushi Kawaguchi, Tomohiko Kanayama, Azusa Hayano, Ryuya Yamanaka
Common cancer treatments include radiation therapy, chemotherapy including molecular targeted drugs and anticancer drugs, and surgical treatment. Recent studies have focused on investigating the mechanisms by which immune cells attack cancer cells and produce immune tolerance-suppressing cytokines, as well as on their potential application in cancer immunotherapy. We conducted expression profiling of CD274 ( PD-L1 ), GATA3, IFNG, IL12R, IL12RB2, IL4, PDCD1 ( PD-1 ), PDCD1LG2 ( PD-L2 ), and TBX21 ( T-bet ) using data of 158 glioblastoma multiforme (GBM) patients with clinical information available at The Cancer Genome Atlas...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29716632/multi-cellular-human-bronchial-models-exposed-to-diesel-exhaust-particles-assessment-of-inflammation-oxidative-stress-and-macrophage-polarization
#11
Jie Ji, Swapna Upadhyay, Xiaomiao Xiong, Maria Malmlöf, Thomas Sandström, Per Gerde, Lena Palmberg
BACKGROUND: Diesel exhaust particles (DEP) are a major component of outdoor air pollution. DEP mediated pulmonary effects are plausibly linked to inflammatory and oxidative stress response in which macrophages (MQ), epithelial cells and their cell-cell interaction plays a crucial role. Therefore, in this study we aimed at studying the cellular crosstalk between airway epithelial cells with MQ and MQ polarization following exposure to aerosolized DEP by assessing inflammation, oxidative stress, and MQ polarization response markers...
May 2, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29708532/development-of-recombinant-proteins-to-treat-chronic-pain
#12
Judith Prado, Jelena Popov-Celeketic, Cristine Steen-Louws, Ramin Raoof, Eric Hack, Niels Eijkelkamp
Chronic pain is difficult to treat and new approaches to resolve persistent pain are urgently needed. Anti-inflammatory cytokines are promising candidates for treating debilitating pain conditions due to their capacity to regulate aberrant neuro-immune interactions. However, physiologically they work in a network of various cytokines, and therefore their therapeutic effect may not be optimal when used as stand-alone drugs. To overcome this limitation, we developed a fusion protein of the anti-inflammatory cytokines IL4 and IL10...
April 11, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29700302/bcl11b-is-essential-for-licensing-th2-differentiation-during-helminth-infection-and-allergic-asthma
#13
Kyle J Lorentsen, Jonathan J Cho, Xiaoping Luo, Ashley N Zuniga, Joseph F Urban, Liang Zhou, Raad Gharaibeh, Christian Jobin, Michael P Kladde, Dorina Avram
During helminth infection and allergic asthma, naive CD4+ T-cells differentiate into cytokine-producing Type-2 helper (Th2) cells that resolve the infection or induce asthma-associated pathology. Mechanisms regulating the Th2 differentiation in vivo remain poorly understood. Here we report that mice lacking Bcl11b in mature T-cells have a diminished capacity to mount Th2 responses during helminth infection and allergic asthma, showing reduced Th2 cytokines and Gata3, and elevated Runx3. We provide evidence that Bcl11b is required to maintain chromatin accessibility at Th2-cytokine promoters and locus-control regions, and binds the Il4 HS IV silencer, reducing its accessibility...
April 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29696026/allergic-t-h-2-response-governed-by-b-cell-lymphoma-6-function-in-naturally-occurring-memory-phenotype-cd4-t-cells
#14
Takashi Ogasawara, Yuko Kohashi, Jun Ikari, Toshibumi Taniguchi, Nobuhide Tsuruoka, Haruko Watanabe-Takano, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Hirokuni Hirata, Yasutsugu Fukushima, Takeshi Fukuda, Kazuhiro Kurasawa, Koichiro Tatsumi, Takeshi Tokuhisa, Masafumi Arima
Transcriptional repressor B-cell lymphoma 6 (Bcl6) appears to regulate TH 2 immune responses in allergies, but its precise role is unclear. We previously reported that Bcl6 suppressed IL-4 production in naïve CD4+ T cell-derived memory TH 2 cells. To investigate Bcl6 function in allergic responses in naturally occurring memory phenotype CD4+ T (MPT) cells and their derived TH 2 (MPTH 2) cells, Bcl6 -manipulated mice , highly conserved intron enhancer (hcIE)-deficient mice , and reporter mice for conserved noncoding sequence 2 (CNS2) 3' distal enhancer region were used to elucidate Bcl6 function in MPT cells...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29692868/epigenome-wide-association-study-of-total-serum-immunoglobulin-e-in-children-a-life-course-approach
#15
Cheng Peng, Andres Cardenas, Sheryl L Rifas-Shiman, Marie-France Hivert, Diane R Gold, Thomas A Platts-Mills, Xihong Lin, Emily Oken, Andrea A Baccarelli, Augusto A Litonjua, Dawn L DeMeo
Background: IgE-mediated sensitization may be epigenetically programmed in utero, but early childhood environment may further alter complex traits and disease phenotypes through epigenetic plasticity. However, the epigenomic footprint underpinning IgE-mediated type-I hypersensitivity has not been well-understood, especially under a longitudinal early-childhood life-course framework. Methods: We used epigenome-wide DNA methylation (IlluminaHumanMethylation450 BeadChip) in cord blood and mid-childhood peripheral blood to investigate pre- and post-natal methylation marks associated with mid-childhood (age 6...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29686684/shared-and-unique-features-distinguishing-follicular-t-helper-and-regulatory-cells-of-peripheral-lymph-node-and-peyer-s-patches
#16
Hristo Georgiev, Inga Ravens, Georgia Papadogianni, Stephan Halle, Bernard Malissen, Gabriela G Loots, Reinhold Förster, Günter Bernhardt
Follicular helper (TFH) and regulatory (TFR) cells are critical players in managing germinal center (GC) reactions that accomplish effective humoral immune responses. Transcriptome analyses were done comparing gene regulation of TFH and TFR cells isolated from Peyer's Patches (PP) and immunized peripheral lymph nodes (pLNs) revealing many regulatory patterns common to all follicular cells. However, in contrast to TFH cells, the upregulation or downregulation of many genes was attenuated substantially in pLN TFR cells when compared to those of PP...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29686176/association-between-arg753gln-and-arg677trp-polymorphisms-of-tlr2-gene-with-active-pulmonary-tuberculosis-in-an-indonesian-population
#17
Arto Yuwono Soeroto, Zulkarnain Dahlan, Cissy B Kartasasmita, Ida Parwati
BACKGROUND: Toll-like receptor is a pattern recognition receptor (PRR) that recognize pathogen-associated molecular pattern (PAMP) in a microorganism. Macrophages recognize the presence of mycobacteria through Toll-Like Receptor 2 (TLR2) and signaling further lead to the production of cytokines, both proinflammatory TNF-α, IL-1β, IL-6, IL-12, IL-15, IL-18 and IFN-γ, as well as anti-inflammatory IL4, IL-10 and TGF-β. TLR2 gene polymorphism is strongly determined by ethnicity and geography...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29684412/no-association-of-il2-il4-il6-tnf-and-ifng-gene-polymorphisms-was-found-with-taenia-solium-human-infection-or-neurocysticercosis-severity-in-a-family-based-study
#18
A Fleury, C Alaez, A Dessein, M Rosetti, B Saenz, M Hernández, R J Bobes, R Aquino, E Sciutto, C Gorodezky, G Fragoso
Neurocysticercosis (NC) is caused by the establishment of the metacestode stage of Taenia solium in the human central nervous system. A great heterogeneity in the susceptibility to the infection and to the disease has been reported. While the factors involved in this heterogeneity are not completely understood, clearly different immune-inflammatory profiles have been associated to each condition. This study evaluated the association of cytokine single nucleotide polymorphisms (SNPs) with susceptibility to infection and disease severity in NC patients...
April 20, 2018: Human Immunology
https://www.readbyqxmd.com/read/29679490/increased-nk-cell-subsets-with-inhibitory-cytokines-and-inhibitory-surface-receptors-in-patients-with-recurrent-miscarriage-and-decreased-or-normal-subsets-in-kidney-transplant-recipients-late-post-transplant
#19
Li Zhu, Mostafa Aly, Haihao Wang, Hristos Karakizlis, Rolf Weimer, Christian Morath, Ruben Jeremias Kuon, Bettina Toth, Naruemol Ekpoom, Gerhard Opelz, Volker Daniel
BACKGROUND: Patients with recurrent miscarriage (RM) show up-regulated cytotoxic NK cells that are suspected to play a causal role in abortion. In the present study, we investigated counter-regulating inhibitory mechanisms and compared the results in RM patients with those of healthy controls (HC), patients with end stage renal disease (ESRD) and kidney transplant recipients late post-transplant (TX). METHODS: NK, NKT and T cell subsets were analyzed in the peripheral blood of 31 RM, 14 female ESRD and 9 female TX patients as well as 21 female HC using eight-color fluorescence flow cytometry...
April 21, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29674199/the-impact-of-female-fetal-sex-on-preeclampsia-and-the-maternal-immune-milieu
#20
Brandie D Taylor, Roberta B Ness, Mark A Klebanoff, Gong Tang, James M Roberts, David M Hougaard, Kristin Skogstrand, Catherine L Haggerty
OBJECTIVE: Small studies suggest that fetal sex alters maternal inflammation. We examined the association between fetal sex, preeclampsia and circulating maternal immune markers. METHODS: This was a secondary data analysis within a nested case-control study of 216 preeclamptic women and 432 randomly selected normotensive controls from the Collaborative Perinatal Project. All women had singleton, primiparous pregnancies without chronic health conditions. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for associations between female fetal sex and preeclampsia...
February 24, 2018: Pregnancy Hypertension
keyword
keyword
31732
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"