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https://www.readbyqxmd.com/read/28209173/moving-from-legality-to-reality-how-medical-abortion-methods-were-introduced-with-implementation-science-in-zambia
#1
Tamara Fetters, Ghazaleh Samandari, Patrick Djemo, Bellington Vwallika, Stephen Mupeta
BACKGROUND: Although abortion is technically legal in Zambia, the reality is far more complicated. This study describes the process and results of galvanizing access to medical abortion where abortion has been legal for many years, but provision severely limited. It highlights the challenges and successes of scaling up abortion care using implementation science to document 2 years of implementation. METHODS: An intervention between the Ministry of Health, University Teaching Hospital and the international organization Ipas, was established to introduce medical abortion and to address the lack of understanding and implementation of the country's abortion law...
February 16, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28207248/mechanochemical-and-conventional-synthesis-of-zn-ii-cd-ii-luminescent-coordination-polymers-dual-sensing-probe-for-selective-detection-of-chromate-anions-and-tnp-in-aqueous-phase
#2
Bhavesh Parmar, Yadagiri Rachuri, Kamal Kumar Bisht, Ridhdhi Laiya, Eringathodi Suresh
Isostructural Zn(II)/Cd(II) mixed ligand coordination polymers (CPs) {[M(IPA)(L)]}n (CP1 and CP2) built from isophthalic acid (H2IPA) and 3-pyridylcarboxaldehyde nicotinoylhydrazone (L) were prepared using versatile synthetic routes: viz., diffusion of precursor solutions, conventional reflux methods, and green mechanochemical (grinding) reactions. Both robust CPs synthesized by different routes were characterized by various analytical methods, and their thermal and chemical stability as well as the phase purity was established...
February 16, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28202357/variations-in-the-arterial-blood-supply-to-the-penis-and-the-accessory-pudendal-artery-a-meta-analysis-and-review-of-its-implications-in-radical-prostatectomy
#3
Brandon Michael Henry, Przemysław A Pękala, Jens Vikse, Beatrice Sanna, Bendik Skinningsrud, Karolina Saganiak, Jerzy A Walocha, Krzysztof A Tomaszewski
PURPOSE: The aim of this meta-analysis was to analyze the available literature and provide comprehensive data on the prevalence and variations of accessory pudendal artery (APA) and the three types of penile blood supply (Type 1 - internal pudendal artery (IPA) only, Type 2 - IPA and APA), Type 3 - APA only) MATERIALS AND METHODS: We conducted an extensive search of the major databases and identified 23 studies (4,945 patients) suitable for inclusion in this meta-analysis. Studies eligible for inclusion included cadaveric, imaging or intraoperative studies...
February 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28202233/practice-makes-perfect-a-systematic-review-of-the-expertise-development-of-pharmacist-and-nurse-independent-prescribers-in-the-united-kingdom
#4
REVIEW
Aseel S Abuzour, Penny J Lewis, Mary P Tully
BACKGROUND: Prescribing is a complex and error-prone task that demands expertise. McLellan et al.'s theory of expertise development model ("the model"), developed to assess medical literature on prescribing by medical students, proposes that in order to develop, individuals should deliberately engage their knowledge, skills and attitudes within a social context. Its applicability to independent prescribers (IP) is unknown. AIM: A systematic review was conducted to explore whether the model is applicable to non-medical independent prescribing and to assess the factors underpinning expertise development reported in the literature...
February 7, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28199183/mrna-mirna-integrative-analysis-of-diabetes-induced-cardiomyopathy-in-rats
#5
Mariana B Lopes, Renata Cc Freitas, Mario H Hirata, Rosario Dc Hirata, Adriana A Rezende, Vivian N Silbiger, Raul H Bortolin, Andre D Luchessi
An integrative analysis of miRNA and mRNA expression profiles in left ventricle (LV) of diabetes-induced rats was performed to elucidate the role of miRNAs and their mRNAs target in diabetic cardiomyopathy (DCM). mRNA (GSE4745) and miRNA (GSE44179) datasets were downloaded from Gene Expression Omnibus 2R (GEO2R) and differentially expressed mRNAs and miRNAs were selected. Cardiotoxicity-related mRNAs (n=7) were analyzed by Ingenuity Pathway Analyses 6 (IPA) and regulatory miRNAs (n=639) were identified using TargetScan 7...
March 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/28187774/assessing-the-experience-of-using-synthetic-cannabinoids-by-means-of-interpretative-phenomenological-analysis
#6
Szilvia Kassai, Judit Nóra Pintér, József Rácz, Brigitta Böröndi, Tamás Tóth-Karikó, Kitti Kerekes, V Anna Gyarmathy
BACKGROUND: New psychoactive substances (NPS) have been increasingly consumed by people who use drugs in recent years, which pose a new challenge for treatment services. One of the largest groups of NPS is synthetic cannabinoids (SCs), which are intended as a replacement to cannabis. While there is an increasing body of research on the motivation and the effects associated with SC use, little is known about the subjective interpretation of SC use by the people who use drugs themselves...
February 10, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28168424/characterization-of-dysregulated-mirna-in-peripheral-blood-mononuclear-cells-from-ischemic-stroke-patients
#7
Marpe Bam, Xiaoming Yang, Souvik Sen, Elizabeth E Zumbrun, Lauren Dennis, Jiajia Zhang, Prakash S Nagarkatti, Mitzi Nagarkatti
Epigenetic modification may play an important role in pathophysiology of ischemic stroke (IS) risk. MicroRNAs (miRNAs), which constitute one of the modes of epigenetic regulation, have been shown to be associated with a number of clinical disorders including IS. The purpose of this study was to investigate the miRNA profile in the peripheral blood mononuclear cells (PBMCs) of IS patients and compare it with stroke-free controls. Blood samples were obtained from 19 healthy age-gender-race matched individuals who served as controls to 20 IS patients...
February 6, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28164052/treatment-of-stiff-elbow-in-young-patients-with-interpositional-arthroplasty-for-mobility-case-series
#8
R Sivakumar, V SomaSheker, Prahalad Kumar Shingi, T Vinoth, M Chidambaram
INTRODUCTION: The elbow is a complex joint involving many articulations and complex biomechanics come into play. Elbow motion is crucial to upper limb movement that loss of 50% of elbow function equals to loss of 80% of upper extremity global function. Restoring movement and stability is challenging to the surgeon while treating a stiff elbow. Unlike other arthroplasties of hip and knee, total elbow arthroplasty (TEA) may not be a primary treatment. Interpositional arthroplasty (IPA) can be considered a viable option in posttraumatic arthritis of elbow in young patients...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28162046/degradation-of-2-4-dichlorophenoxyacetate-isopropyl-amine-2-4-d-ipa-by-o3-ac-uv-in-an-internally-slurry-airlift-photo-reactor
#9
Jamshid Behin, Negin Farhadian
An externally illuminated slurry airlift reactor (ALR) was used to decompose 2,4-D IPA during catalytic ozonation with activated carbon. The effect of superficial gas velocity (0.05-0.15 cm/s), UVAB irradiation (0-60 W), treatment period (10-30 min) and amount of activated carbon (0-0.8 g/l) on removal efficiency was investigated using response surface methodology (RSM) based on Box-Behnken surface statistical design. Well-defined circulation pattern in the ALR allowed all the fluid elements to be exposed to high light intensity zone and achieve sufficient contact between the solid catalyst and the pollutant...
February 6, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28159039/a-radiographic-analysis-of-the-contribution-of-hallux-valgus-interphalangeus-to-the-total-valgus-deformity-of-the-hallux
#10
Andrew Strydom, Nikiforos Pandelis Saragas, Paulo Norberto Faria Ferrao
BACKGROUND: The hallux valgus interphalangeus (HVI) deformity is described as rare, but improved outcomes in hallux valgus (HV) surgery is associated with its surgical correction via an Akin osteotomy. The hypothesis of this study is that HVI is common and makes a significant contribution to the total valgus deformity of the hallux (TVDH). METHODS: 285 pre-operative foot radiographs (193 with HV, 92 non-HV), utilising standardised radiographic and measurement techniques, were analysed retrospectively...
March 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28155252/the-meta-analytical-paradigm-in-an-in-silico-hybrid-pathways-and-networks-perturbed-during-exposure-to-varying-degrees-of-hypobaric-hypoxia
#11
Subhojit Paul, Kalpana Bhargava, Yasmin Ahmad
PURPOSE: Computational biology has opened a gateway to omics data analysis and shifted the focus from molecules to systemic molecular networks in the domain of hypobaric hypoxia (HH). Yet there are no meta-analytical investigations circum-venting constraints like organism (rat/human), HH exposure conditions (acute/chronic) and the tissues that can be investigated simultaneously in the realm of wet-lab experiments. EXPERIMENTAL DESIGN: We analyzed 154 DE proteins upon HH exposure using IPA tool, without the constraint of using a single organism or tissue type, to determine the most significant pathways and networks that are perturbed across a range of HH conditions RESULTS: : We found Acute phase Response Signaling, FXR/RXR Activation, LXR/RXR Activation, Clathrin-mediated endocytosis signaling, Mitochondrial Dysfunction, Production of Nitric Oxide & ROS in Macrophages and Integrin Signaling to be the most significant universally perturbed pathways...
February 2, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28153533/dysregulation-of-gene-expression-in-the-striatum-of-bachd-rats-expressing-full-length-mutant-huntingtin-and-associated-abnormalities-on-molecular-and-protein-levels
#12
Libo Yu-Taeger, Michael Bonin, Janice Stricker-Shaver, Olaf Riess, Hoa Huu Phuc Nguyen
Huntington disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the gene coding for the huntingtin protein (HTT). Mutant HTT (mHTT) has been proposed to cause neuronal dysfunction and neuronal loss through multiple mechanisms. Transcriptional changes may be a core pathogenic feature of HD. Utilizing the Affymetrix platform we performed a genome-wide RNA expression analysis in two BACHD transgenic rat lines (TG5 and TG9) at 12 months of age, both of which carry full-length human mHTT but with different expression levels...
January 30, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28145615/experiences-of-adolescent-lung-transplant-recipients-a%C3%A2-qualitative-study
#13
S M Anderson, J Wray, A Ralph, H Spencer, T Lunnon-Wood, K Gannon
Many young transplant recipients experience psychological distress and adjustment difficulties, yet there is little research investigating lung transplantation from the recipients' perspective. This qualitative study aimed to explore experiences of young people who underwent lung transplantation. Semi-structured interviews were conducted with six lung transplant recipients (aged 15-18). Interviews were analysed using IPA, a qualitative research approach examining how people make sense of their major life experiences...
February 1, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28134492/alcohol-use-alcohol-related-aggression-and-intimate-partner-abuse-a-cross-sectional-survey-of-convicted-versus-general-population-men-in-scotland
#14
Elizabeth Allison Gilchrist, Lana Ireland, Alasdair Forsyth, Jon Godwin, Tim Laxton
INTRODUCTION AND AIMS: Scotland has a particular problem with alcohol, and the links between intimate partner abuse (IPA) and alcohol appear stronger here than elsewhere across Europe. This study explored differences in alcohol use, related aggression and relationship conflict across a number of groups: men convicted for intimate partner abuse, men convicted of general offences and men recruited from community sports teams. DESIGN AND METHODS: Participants (n = 64) completed three questionnaires exploring their experiences of alcohol use (Alcohol Use Disorders Identification Test, AUDIT); alcohol and aggression (Alcohol Related Aggression Questionnaire, ARAQ-28), and relationship conflict (Revised Conflict Tactics Scale, CTS-2)...
January 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28132972/a-new-desorption-method-for-removing-organic-solvents-from-activated-carbon-using-surfactant
#15
Mitsuo Hinoue, Sumiyo Ishimatsu, Yukiko Fueta, Hajime Hori
OBJECTIVES: A new desorption method was investigated, which does not require toxic organic solvents. Efficient desorption of organic solvents from activated carbon was achieved with an ananionic surfactant solution, focusing on its washing and emulsion action. METHODS: Isopropyl alcohol (IPA) and methyl ethyl ketone (MEK) were used as test solvents. Lauryl benzene sulfonic acid sodium salt (LAS) and sodium dodecyl sulfate (SDS) were used as the surfactant. Activated carbon (100 mg) was placed in a vial and a predetermined amount of organic solvent was added...
January 28, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28127611/liquid-identification-by-using-a-micro-electro-mechanical-interdigital-transducer
#16
ThuHang Bui, Bruno Morana, Atef Akhnoukh, Trinh Chu Duc, Pasqualina M Sarro
A surface-acoustic-mode aluminum nitride (AlN) transducer is utilized to determine the type of liquid dropped on the propagation path. It is based on tracking the shrinking droplet radius and observing stagnant liquid molecules during and after the liquid evaporation process. The device configuration is suitable to test small amounts of liquids, in the microliter range. According to both mass loading and physical property mechanisms, eight samples of liquids, isopropanol (IPA), ethanol (ETH), deionized-water (DW), tap water (TW), heptane (HEP), propylene glycol monomethyl ether acetate (PGMEA), hexamethyldisilazane (HMDS) and acetone (ACE), which have different equilibrium vapor pressures, molecular weights and boiling points, are accurately detected...
January 27, 2017: Analyst
https://www.readbyqxmd.com/read/28125591/maternal-pre-pregnancy-obesity-is-associated-with-altered-placental-transcriptome
#17
Signe Altmäe, Maria Teresa Segura, Francisco J Esteban, Sabine Bartel, Pilar Brandi, Martin Irmler, Johannes Beckers, Hans Demmelmair, Carmen López-Sabater, Berthold Koletzko, Susanne Krauss-Etschmann, Cristina Campoy
Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes. However, the molecular mechanisms underlying these processes are poorly understood. We analysed ten term placenta's whole transcriptomes in obese (n = 5) and normal weight women (n = 5), using the Affymetrix microarray platform. Analyses of expression data were carried out using non-parametric methods...
2017: PloS One
https://www.readbyqxmd.com/read/28117738/in-vitro-biotransformation-of-two-human-cyp3a-probe-substrates-and-their-inhibition-during-early-zebrafish-development
#18
Evy Verbueken, Derek Alsop, Moayad A Saad, Casper Pype, Els M Van Peer, Christophe R Casteleyn, Chris J Van Ginneken, Joanna Wilson, Steven J Van Cruchten
At present, the zebrafish embryo is increasingly used as an alternative animal model to screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos depend on their own drug-metabolizing capacity, knowledge of their intrinsic biotransformation is pivotal in order to correctly interpret the outcome of teratogenicity assays. Therefore, the aim of this in vitro study was to assess the activity of cytochrome P450 (CYP)-a group of drug-metabolizing enzymes-in microsomes from whole zebrafish embryos (ZEM) of 5, 24, 48, 72, 96 and 120 h post-fertilization (hpf) by means of a mammalian CYP substrate, i...
January 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28117370/costunolide-and-dehydrocostuslactone-combination-treatment-inhibit-breast-cancer-by-inducing-cell-cycle-arrest-and-apoptosis-through-c-myc-p53-and-akt-14-3-3-pathway
#19
Zhangxiao Peng, Yan Wang, Jianhui Fan, Xuejing Lin, Chunying Liu, Yang Xu, Weidan Ji, Chao Yan, Changqing Su
Our previous studies demonstrated that volatile oil from saussurea lappa root (VOSL), rich in two natural sesquiterpene lactones, costunolide (Cos) and dehydrocostuslactone (Dehy), exerts better anti-breast cancer efficacy and lower side effects than Cos or Dehy alone in vivo, however, their anti-cancer molecular mechanisms were still unknown. In this study, we investigated the underlying mechanisms of Cos and Dehy combination treatment (CD) on breast cancer cells through proteomics technology coupled with Western blot validation...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28116760/deconstructing-the-associations-between-executive-functioning-problematic-alcohol-use-and-intimate-partner-aggression-a-dyadic-analysis
#20
Dominic J Parrott, Kevin M Swartout, Christopher I Eckhardt, Olivia S Subramani
INTRODUCTION AND AIMS: Problematic drinking and executive functioning deficits are two known risk factors for intimate partner aggression (IPA). However, executive functioning is a multifaceted construct, and it is not clear whether deficits in specific components of executive functioning are differentially associated with IPA perpetration generally and within the context of problematic alcohol use. To address this question, the present study investigated the effects of problematic drinking and components of executive functioning on physical IPA perpetration within a dyadic framework...
January 2017: Drug and Alcohol Review
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