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https://www.readbyqxmd.com/read/29150852/panel%C3%A2-report-ipa-congress-buenos-aires-2017-listening-for-echoes-of-the-child-in-adult-psychoanalysis
#1
Anand Desai
No abstract text is available yet for this article.
November 17, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/29150624/semiquantative-visual-assessment-of-sub-solid-pulmonary-nodules-%C3%A2-3%C3%A2-cm-in-differentiation-of-lung-adenocarcinoma-spectrum
#2
Fu-Zong Wu, Po-An Chen, Carol C Wu, Pei-Lun Kuo, Shu-Ping Tsao, Chu-Chun Chien, En-Kuei Tang, Ming-Ting Wu
We aimed to analyze CT features of persistent subsolid nodules (SSN) ≦3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate whether parameters enable distinction between invasive pulmonary adenocarcinomas (IPAs) and pre-invasive lesions. A total of 129 patients with 141 SSNs confirmed with surgically pathologic proof were retrospectively reviewed. Of 141 SSNs, there were 57 pure ground-glass nodules (GGNs), 22 heterogeneous GGNs, and 62 part-solid nodules. SSN subclassification showed a significant linear trend with invasive degree of the adenocarcinoma spectrum (pure GGNs 7%; heterogeneous GGNs 36...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29148620/perceptions-of-adults-with-overweight-obesity-and-chronic-musculoskeletal-pain-an-interpretative-phenomenological-analysis
#3
Lesley Cooper, Louisa Ells, Cormac Ryan, Denis Martin
AIMS: To gain insight into the lived experience of adults with overweight/obesity and chronic musculoskeletal pain (CMP). Knowledge gained will inform healthcare professionals about the complexity of the weight-pain relationship and enable more effective engagement with this population BACKGROUND: Quantitative studies show links between weight and pain. Adults with overweight/obesity are more likely to experience comorbidity however, qualitative research describing the complexities of the relationship is limited...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29148571/panel%C3%A2-report-ipa-congress-buenos-aires-2017-claustro-agoraphobia-bertram-lewin-and-the-oral-triad-6-april-2017
#4
Béatrice Ithier
No abstract text is available yet for this article.
November 17, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/29148176/differential-proteomic-analysis-reveals-protein-networks-and-pathways-that-may-contribute-to-helicobacter-pylori-fkbp-type-ppiase-associated-gastric-diseases
#5
Yanmei Zhu, Yuehua Gong, Aodi Li, Moye Chen, Dan Kang, Jun Liu, Yuan Yuan
PURPOSE: Though Helicobacter pylori (H. pylori) has been classified as class I carcinogen, key virulence factor generated by H. pylori that causes gastric cancer remains to be fully determined. Recently, we identified a gastric cancer-associated H. pylori gene, peptidylprolyl isomerase-FK506 binding protein (PPIase-FKBP), and showed that PPIase-FKBP was capable of inducing oncogenic transformation of gastric epithelial cells. But its mechanism was unclear. EXPERIMENTAL DESIGN: We carried out a comparative proteomic analysis of human gastric epithelial cells that either express PPIase-FKBP or green fluorescent protein (GFP) using two-dimensional (2-D) gel electrophoresis and then matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS/MS)...
November 16, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29146389/a-case-of-psoas-abscess-after-robotic-assisted-laparoscopic-hysterectomy-and-pelvic-lymphadenectomy
#6
Vanessa Rigaud, Pengfei Wang, Ashley Bartalot, Farr Nezhat
Iliopsoas abscess (IPA) is a rare condition seen in a variety of specialties that presents with nonspecific complaints. Presented herein is the development of an IPA after robotic staging with sentinel lymaphadenectomy for endometrial carcinoma. Patient is a 61yo female with history of prolonged immunosuppressive therapy due to psoriasis. She presented with an IPA, eight weeks after a robotic-assisted laparoscopic hysterectomy, BSO, and sentinel lymph node dissection. The patient was treated and cured with empiric antibiotics and IR drainage...
November 13, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29146188/old-drug-new-tricks-chlorhexidine-acts-as-a-potential-allosteric-inhibitor-toward-pak1
#7
Han-Wei Huang, Xiang-Yu Zhang, Pei-Lu Song, Hai-Lun Jiang, Wei Li, Peng-Liang Wang, Jian Wang, Fu-Nan Liu
This paper describes the identification of chlorhexidine, an agent commonly used in clinical as a novel potential allosteric inhibitor of PAK1. In cellular assays, chlorhexidine showed a good inhibitory profile, and its inhibitory profile was even better than IPA-3, a well-known allosteric inhibitor. In pharmacology experiments, chlorhexidine successfully inhibited the relief of PAK1 dimer and inhibited the activation of PAK1. Our findings offer an insight for the new drug development of PAK1 inhibitor. We also provide a possible explanation for the phenomenon that the application of the chlorhexidine in peritoneal lavage inhibited the development of tumor...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29145837/molecular-network-based-analysis-of-the-mechanism-of-liver-injury-induced-by-volatile-oils-from-artemisiae-argyi-folium
#8
Hongjie Liu, Sha Zhan, Yan Zhang, Yan Ma, Liang Chen, Lingxiu Chen, Hanqiu Dong, Min Ma, Zhe Zhang
BACKGROUND: Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear. METHODS: In the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA). The chemical components of the VOAAF were searched in the database, and their target proteins were all identified in the PubChem, while drug-induced liver injury (DILI) genes were searched in the PubMed gene databases...
November 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29143255/pcb-exposure-and-potential-future-cancer-incidence-in-slovak-children-an-assessment-from-molecular-finger-printing-by-ingenuity-pathway-analysis-ipa%C3%A2-derived-from-experimental-and-epidemiological-investigations
#9
Somiranjan Ghosh, Christopher A Loffredo, Partha S Mitra, Tomas Trnovec, Lubica Palkovicova Murinova, Eva Sovcikova, Eric P Hoffman, Kepher H Makambi, Sisir K Dutta
The risk of cancer due to PCB exposure in humans is highly debated. In eastern Slovakia, high exposure of the population to organochlorines (especially PCBs) was associated with various disease and disorder pathways, viz., endocrine disruption, metabolic disorder & diabetes, and cancer, thereby disturbing several cellular processes, including protein synthesis, stress response, and apoptosis. We have evaluated a Slovak cohort (45-month children, at lower and higher levels of PCB exposure from the environment) for disease and disorder development to develop early disease cancer biomarkers that could shed new light on possible mechanisms for the genesis of cancers under such chemical exposures, and identify potential avenues for prevention...
November 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29139155/additive-enhanced-crystallization-of-solution-process-for-planar-perovskite-solar-cells-with-efficiency-exceeding-19
#10
Shuai You, Shiqing Bi, Jing Huang, Qiushuang Jia, Yuhe Yuan, Yanjie Xia, Zhenyu Xiao, Zhuzhu Sun, Jiangfeng Liu, Shujie Sun, Zhiqiang Zhao
To reduce intrinsic defect density in perovskite films, various additives are often added into the precursor solution. In this paper, a novel solution approach where isopropanol (IPA) was added into the precursor solution was developed for the preparation of normal planar perovskite solar cells (PSCs). A champion power conversion efficiency (PCE) of 19.70% was achieved with this approach. By adding IPA into the precursor solution, CH3NH3PbI3 perovskite showed better crystallization and stability, indicating improved film quality...
November 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29137633/bi-directional-exosome-driven-intercommunication-between-the-hepatic-niche-and-cancer-cells
#11
Nikolina Dioufa, Amanda M Clark, Bo Ma, Colin H Beckwitt, Alan Wells
BACKGROUND: Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not been widely appreciated. METHODS: Using our all-human liver microphysiological system (MPS) platform as a model to closely recapitulate the early metastatic events, we isolated exosomes from both tumor cells and liver microenvironment. RESULTS: We observed that while priming of the hepatic niche (HepN) with MDA-231 breast cancer derived exosomes facilitated seeding of the cancer cells in the liver, subsequent tumor outgrowth was diminished; this was consistent with increased entry into dormancy...
November 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29136834/comparative-proteomics-of-cancer-stem-cells-in-osteosarcoma-using-ultra-high-performance-liquid-chromatography-and-orbitrap-fusion-mass-spectrometer
#12
Zhihui Zhong, Sifeng Mao, Haifeng Lin, Jin-Ming Lin, Jianhua Lin
Osteosarcoma is the most common malignant tumour found in bones, and it has a poor prognosis. For improved therapy, it is significant to have a deep understanding of the proteomics changes in the cancer stem cells (CSCs) of osteosarcoma. Therefore, a comparative proteomics approach based on ultra-high-performance liquid chromatography coupled to an Orbitrap Fusion mass spectrometer (UHPLC-Orbitrap Fusion MS) was established to investigate the key molecular changes between CSCs and non-CSCs in human osteosarcoma HOS cells...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29134352/accuracy-of-apparent-diffusion-coefficient-in-differentiating-pancreatic-neuroendocrine-tumour-from-intrapancreatic-accessory-spleen
#13
Ankur Pandey, Pallavi Pandey, Mounes Aliyari Ghasabeh, Farnaz Najmi Varzaneh, Pegah Khoshpouri, Nannan Shao, Manijeh Zargham Pour, Daniel Fadaei Fouladi, Ralph H Hruban, Anne Marie O'Broin-Lennon, Ihab R Kamel
OBJECTIVES: To evaluate and compare the accuracy of absolute apparent diffusion coefficient (ADC) and normalised ADC (lesion-to-spleen ADC ratio) in differentiating pancreatic neuroendocrine tumour (NET) from intrapancreatic accessory spleen (IPAS). METHODS: Study included 62 patients with the diagnosis of pancreatic NET (n=51) or IPAS (n=11). Two independent reviewers measured ADC on all lesions and spleen. Receiver operating characteristics (ROC) analysis to differentiate NET from IPAS was performed and compared for absolute and normalised ADC...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29133384/estrogen-and-high-fat-diet-induced-alterations-in-c57bl-6-mice-endometrial-transcriptome-profile
#14
Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen, Qin Zhu
Unopposed estrogen stimulation and insulin resistance are known to play important roles in endometrial cancer (EC), but the interaction between these two factors and how they contribute to endometrial lesions are not completely elucidated. To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance...
November 13, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29131325/panel%C3%A2-report-ipa-congress-buenos-aires-2017-pleasure-and-intimacy
#15
Fabio Eslava
No abstract text is available yet for this article.
November 13, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/29128933/proven-invasive-pulmonary-aspergillosis-in-stem-cell-transplant-recipient-due-to-aspergillus-sublatus-a-cryptic-species-of-a-nidulans
#16
Vanda Chrenkova, Vit Hubka, Petr Cetkovsky, Michal Kouba, Barbora Weinbergerova, Pavlina Lyskova, Ludmila Hornofova, Petr Hubacek
Invasive fungal disease represents one of the severe complications in haematopoietic stem cell transplant recipients. We describe a case of a patient treated for relapse of chronic lymphoblastic leukaemia 6 years after HSCT. The patient was treated for invasive pulmonary aspergillosis but died 3 months later from multiple organ failures consisting of haemorrhagic necrotizing fungal pneumonia, refractory chronic hepatic graft versus host disease and cytomegalovirus hepatitis. Autopsy samples revealed histopathological evidence of fungal hyphae and an unusual Aspergillus nidulans-like species was isolated in pure culture...
November 11, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29126925/comparative-transcriptomic-characterization-of-a-new-mib-mutant-allele-mib-nn2002-in-zebrafish
#17
Keng Po Lai, Jing-Woei Li, Chia-Hao Hsu, May-Su You, Ting-Fung Chan, William Ka Fai Tse, Yun-Jin Jiang
mib(nn2002), identified from an allele screen, shows early segmentation defect and severe cell death phenotypes, which are different from those of other described mib mutant alleles. We have previously reported its defects in somitogenesis and identified its origin of mutation, a large deletion in LG2. The report here is a continuous study, where we applied the bioinformatics analysis to profile the genetic background of mib(nn2002) mutants. By comparing the transcriptomic data of mib(nn2002) mutants with those of AB wild-type, a total of 1945 differentially expressed genes were identified, including 685 up- and 1260 down-regulated genes...
November 7, 2017: Gene
https://www.readbyqxmd.com/read/29126429/rna-sequencing-analysis-of-lung-primary-fibroblast-response-to-eosinophil-degranulation-products-predicts-downstream-effects-on-inflammation-tissue-remodeling-and-lipid-metabolism
#18
Stephane Esnault, Ksenija Bernau, Elizabeth E Torr, Yury A Bochkov, Nizar N Jarjour, Nathan Sandbo
BACKGROUND: The association of eosinophils with inflammation and tissue remodeling is at least partially due to their release of toxic granule proteins and other mediators, including cytokines. Tissue remodeling and consequent functional defects are affected by activity of connective tissue fibroblasts. Exaggerated fibroblast activation, accumulation and change of phenotype may lead to fibrosis and loss of tissue function. So far, little information has been reported on how eosinophils affect inflammation and tissue remodeling via the activation of fibroblasts...
November 10, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29125660/primary-prophylaxis-of-invasive-fungal-infections-with-posaconazole-or-itraconazole-in-patients-with-acute-myeloid-leukemia-or-high-risk-myelodysplastic-syndromes-undergoing-intensive-cytotoxic-chemotherapy-a-real-world-comparison
#19
Mar Tormo, Ariadna Pérez-Martínez, Marisa Calabuig, Juan Carlos Hernández-Boluda, Paula Amat, David Navarro, Carlos Solano
This is an observational-retrospective study comparing the real-world outcomes associated with posaconazole vs. itraconazole as prophylaxis treatments. Two hundred and ninety-three patient admissions attributable to 174 patients were included in the study. Patients were treated with itraconazole (n = 114 admissions; 39%) or posaconazole (n = 179; 61%). Antifungal prophylaxis failure (APF) due to treatment-related adverse events (in 34 out of 293 patient admissions; 11.6%) was more frequent in the posaconazole group (6...
November 10, 2017: Mycoses
https://www.readbyqxmd.com/read/29122669/osteoanabolic-activity-of-whey-derived-anti-oxidative-mhirl-and-yveel-and-angiotensin-converting-enzyme-inhibitory-yllf-alpmhir-ipa-and-wlahk-bioactive-peptides
#20
Masum Pandey, Rajeev Kapila, Suman Kapila
Exploring bone rebuilding anabolic agents has been gaining much attention due to their potential therapeutic effects in treating several bone disorders including osteoporosis. Whey protein has been reported to affect bone health osteoanabolically, in terms of proliferation and differentiation of primary osteoblast cells. This study investigates whether whey derived anti-oxidative (AO) (P1- MHIRL, P2- YVEEL) and angiotensin converting enzyme inhibitory (ACE inhibitory) (P3- YLLF, P4-ALPMHIR, P5-IPA, P6- WLAHK) bioactive peptides affect the proliferation and differentiation of primary osteoblast cells isolated from rat calvaria...
November 6, 2017: Peptides
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