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https://www.readbyqxmd.com/read/28345459/n6-isopentenyladenosine-promoted-hela-cell-apoptosis-through-inhibitions-of-akt-and-transforming-growth-factor-%C3%AE-activated-kinase-1-activation
#1
Miao Li, Yonghao Qi, Jing Wei, Lulu Lu, Xuan Zhao, Lijun Zhou
N6-Isopentenyladenosine, a member of the family of plant hormones, possesses anti-cancer activities on a number of cancer cell lines. However, its mode of action in cervical cancer cell remains poorly understood. Our computational docking studies showed that N6-Isopentenyladenosine could bind with the really interesting new gene domain of tumor necrosis factor receptor-associated factor 6, which is an ubiquitination E3 ligase. Tumor necrosis factor receptor-associated factor 6-mediated ubiquitination is known to activate both protein kinase B (also known as AKT) and transforming growth factor β-activated kinase 1, and the really interesting new gene domain comprises the core of the ubiquitin ligase catalytic domain...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28344507/patients-experience-of-using-primary-care-services-in-the-context-of-indonesian-universal-health-coverage-reforms
#2
Fitriana Murriya Ekawati, Mora Claramita, Krishna Hort, John Furler, Sharon Licqurish, Jane Gunn
BACKGROUND: The World Health Organization (WHO) recommendation on universal coverage has been implemented in Indonesia as Jaminan Kesehatan Nasional (JKN). It was designed to provide people with equitable and high-quality health care by strengthening primary care as the gate-keeper to hospitals. However, during its first year of implementation, recruitment of JKN members was slow, and the referral rates from primary to secondary care remained high. Little is known about how the public views the introduction of JKN or the factors that influence their decision to enroll in JKN...
2017: Asia Pacific Family Medicine
https://www.readbyqxmd.com/read/28332233/tnf-inhibitor-associated-psoriatic-alopecia-diagnostic-utility-of-sebaceous-lobule-atrophy
#3
REVIEW
Olga K Afanasiev, Cathryn Z Zhang, Steven M Ruhoy
BACKGROUND: The increasingly successful and widespread use of TNF inhibitors (TNFi) to treat autoimmune and inflammatory conditions has also been accompanied by adverse reactions, both systemic and cutaneous. Psoriasiform cutaneous rashes are well described. Recently, TNF inhibitor associated psoriatic alopecia (TiAPA) is being more frequently reported. OBJECTIVE: The purpose of this study is to describe the features of TiAPA, including marked atrophy of sebaceous lobules as a histologic clue to diagnosis, helping to distinguish it from other types of alopecia...
March 23, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28331550/experiences-of-mobility-for-people-living-with-rheumatoid-arthritis-who-are-receiving-biologic-drug-therapy-implications-for-podiatry-services
#4
Lucy Sanders, Margaret Donovan-Hall, Alan Borthwick, Catherine J Bowen
BACKGROUND: Despite significant advancements in new treatment modalities for rheumatoid arthritis with biological therapies, foot complications remain a disabling and common feature of the disease. In this study the aim was to explore and describe the personal experiences of people with rheumatoid arthritis in receipt of biologic treatments in a bid to understand the impact of this form of medication on their mobility. METHODS: An interpretative phenomenological analysis (IPA) was undertaken to explore in depth the individual experience of rheumatoid disease through personal accounts of the patient journey spanning both 'before' and 'after' the instigation of biologic therapy...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28323874/c-type-allatostatins-mimic-stress-related-effects-of-alarm-pheromone-on-honey-bee-learning-and-memory-recall
#5
Elodie Urlacher, Jean-Marc Devaud, Alison R Mercer
As honey bee populations worldwide are declining there is an urgent need for a deeper understanding of stress reactivity in these important insects. Our data indicate that stress responses in bees (Apis mellifera L.) may be mediated by neuropeptides identified, on the basis of sequence similarities, as allatostatins (ASTA, ASTC and ASTCC). Effects of allatostatin injection are compared with stress-related changes in learning performance induced by the honeybee alarm pheromone, isopentylacetate (IPA). We find that bees can exhibit two markedly different responses to IPA, with opposing effects on learning behaviour and memory generalisation, and that strikingly similar responses can be elicited by allatostatins, in particular ASTCC...
2017: PloS One
https://www.readbyqxmd.com/read/28321695/solubility-and-thermodynamic-analysis-of-antihypertensive-agent-nitrendipine-in-different-pure-solvents-at-the-temperature-range-of-298-15-to-318-15%C3%A2-k
#6
Abdul Ahad, Faiyaz Shakeel, Mohammad Raish, Fahad I Al-Jenoobi, Abdullah M Al-Mohizea
The aim of the present study was to ascertain the solubility of nitrendipine (NP), an antihypertensive drug in six different pure solvents such as water, ethyl acetate (EA), ethanol, isopropyl alcohol (IPA), polyethylene glycol-400 (PEG-400), and Transcutol at temperature from 298.15 to 318.15 K under atmospheric pressure (p) of 0.1 MPa. Experimental solubility data of NP was fitted with Apelblat and ideal models. The mole fraction solubility of NP was found maximum in PEG-400 (6.85 × 10(-2) at 318.15 K) followed by Transcutol (4...
March 20, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28320536/retention-models-and-interaction-mechanisms-of-benzene-and-other-aromatic-molecules-with-an-amylose-based-sorbent
#7
Han-Yu Hsieh, Shyuan-Guey Wu, Hung-Wei Tsui
Stoichiometric displacement models have been widely used for understanding the adsorption mechanisms of solutes in chromatography systems. Such models are used for interpreting plots of solute retention factor versus concentrations of polar modifier in an inert solvent. However, these models often assume that dispersion forces are negligible and they are unable to account for solutes with significant aromatic interactions. In this study, a systematic investigation of the relationship between retention behavior and aromatic groups was performed using five simple aromatic molecules-benzene, naphthalene, mesitylene, durene, and toluene-with a commercially available amylose tris(3,5-dimethylphenylcarbamate)-based sorbent...
March 8, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28317902/a-natural-tandem-array-alleviates-epigenetic-repression-of-ipa1-and-leads-to-superior-yielding-rice
#8
Lin Zhang, Hong Yu, Bin Ma, Guifu Liu, Jianjun Wang, Junmin Wang, Rongcun Gao, Jinjun Li, Jiyun Liu, Jing Xu, Yingying Zhang, Qun Li, Xuehui Huang, Jianlong Xu, Jianming Li, Qian Qian, Bin Han, Zuhua He, Jiayang Li
Super hybrid rice varieties with ideal plant architecture (IPA) have been critical in enhancing food security worldwide. However, the molecular mechanisms underlying their improved yield remain unclear. Here, we report the identification of a QTL, qWS8/ipa1-2D, in the super rice Yongyou12 (YY12) and related varieties. In-depth genetic molecular characterization of qWS8/ipa1-2D reveals that this newly identified QTL results from three distal naturally occurring tandem repeats upstream of IPA1, a key gene/locus previously shown to shape rice ideal plant architecture and greatly enhance grain yield...
March 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28317501/temporal-effects-of-perpetrating-or-receiving-intimate-partner-aggression-on-alcohol-consumption-a-daily-diary-study-of-community-couples
#9
Jaye L Derrick, Maria Testa
OBJECTIVE: Survey studies provide evidence that experiencing intimate partner aggression (IPA) contributes to subsequent alcohol use. However, it is unknown whether the increase in alcohol use over time reflects a temporal effect of IPA. We examined verbal and physical IPA as predictors of alcohol use and heavy drinking within the next few hours. We also investigated whether both victims and perpetrators drank following IPA, and if it mattered which partner reported the aggression. METHOD: The data reported here were derived from a 56-day diary study examining the association between alcohol use and partner aggression in 118 heterosexual couples...
March 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28293639/proteomic-analysis-of-liver-proteins-in-a-rat-model-of-chronic-restraint-stress-induced-depression
#10
Cong Li, Zhengguang Guo, Ronghua Zhao, Wei Sun, Ming Xie
Depression is a global mental disorder disease and greatly threatened human health and stress is considered to be one of the important factors that lead to depression. In this study, we used newly developed iTRAQ labeling and high performance liquid chromatography (HPLC) and mass spectrum united analysis technology obtained the 2176 accurate proteins. Successively, we used the GO analysis and IPA software to analyze the 98 differentially expressed proteins of liver in depression rats due to chronic restraint stress, showing a map of proteomics analysis of liver proteins from the aspects of related functions, disease and function analysis, canonical pathway analysis, and associated network...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28292284/is-bulpa-criteria-suitable-for-the-diagnosis-of-probable-invasive-pulmonary-aspergillosis-in-critically-ill-patients-with-chronic-obstructive-pulmonary-disease-a-comparative-study-with-eortc-msg-and-icu-criteria
#11
Linna Huang, Hangyong He, Jingjing Jin, Qingyuan Zhan
BACKGROUND: Three diagnostic criteria have been proposed used for invasive pulmonary aspergillosis (IPA) diagnosis, namely EORTC/ MSG criteria, Bulpa criteria and intensive care unit (ICU) criteria. The Bulpa criteria were proposed to diagnose IPA in chronic obstructive pulmonary disease (COPD) patients specially. Our aim is to verify that whether the Bulpa criteria are the most suitable for diagnosing probable IPA in critically ill COPD patients compared with the other two criteria. METHODS: We included critically ill COPD patients admitted to the ICU from April 2006 to August 2013...
March 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28286304/regulation-of-hypoxia-inducible-gene-expression-after-hif-activation
#12
Norio Suzuki, Katarina Gradin, Lorenz Poellinger, Masayuki Yamamoto
Hypoxia causes dramatic changes in the expression profiles of genes that encode glycolytic enzymes, vascular endothelial growth factors, erythropoietin, and other factors in a tissue-specific manner through activating hypoxia-inducible transcription factors (HIFs) such as HIF1α and HIF2α. It has been elucidated that the activity of HIFs is fundamentally regulated by their protein stability in an oxygen-dependent manner. However, little is known about how stabilized HIFs regulate transcription of their target genes in hypoxic cells...
March 9, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28285530/comparison-of-gluten-extraction-protocols-assessed-by-lc-ms-ms-analysis
#13
Azadeh Fallahbaghery, Wei Zou, Keren Byrne, Crispin A Howitt, Michelle L Colgrave
The efficiency of gluten extraction is of critical importance to the results derived from any analytical method for gluten detection and quantitation, whether it employs reagent-based technology (antibodies) or analytical instrumentation (mass spectrometry). If the target proteins are not efficiently extracted, the end result will be an under-estimation in the gluten content posing a health risk to people affected by conditions such as celiac disease (CD) and nonceliac gluten sensitivity (NCGS). Five different extraction protocols were investigated using LC-MRM-MS for their ability to efficiently and reproducibly extract gluten...
March 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28281338/fully-ambient-processed-perovskite-film-for-perovskite-solar-cells-the-effect-of-solvent-polarity-on-lead-iodide
#14
Wei-Ting Wang, Sandeep K Das, Yian Tai
Fully ambient-processed and highly efficient methylamine lead iodide (MAPbI3) perovskite films are very desirable for industrial manufacturing of perovskite solar cells (PSCs). To date, most reported highly efficient MAPbI3 PSCs rely on the fabrication of lead iodide (PbI2) films inside the glovebox. Here we report a simple fabrication method using extra dry isopropanol (IPA100) for obtaining uniform and loosely packed PbI2 film, which leads to a uniform and highly crystalline MAPbI3 film under ambient conditions...
March 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28277409/randomized-controlled-trial-of-two-alcohol-based-preparations-for-surgical-site-antisepsis-in-colorectal-surgery
#15
Robyn B Broach, Emily C Paulson, Charles Scott, Najjia N Mahmoud
OBJECTIVE: To compare 2 alcohol-based, dual-action skin preparations for surgical site infection (SSI) prevention in elective colorectal surgery. BACKGROUND: Colorectal surgery is associated with the highest SSI rate among elective surgical procedures. Although evidence indicates that alcohol-based skin preparations are superior in SSI prevention, it is not clear if different alcohol-based preparations are equivalent in clean-contaminated colorectal procedures. METHODS: We performed a blinded, randomized, noninferiority trial comparing iodine povacrylex-alcohol (IPA) and chlorhexidine-alcohol for elective, clean-contaminated colorectal surgery...
March 8, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28275471/immunity-status-of-invasive-pulmonary-aspergillosis-patients-with-structural-lung-diseases-in-chinese-adults
#16
Shuo Liang, Rong Jiang, Hai-Wen Lu, Bei Mao, Man-Hui Li, Cheng-Wei Li, Shu-Yi Gu, Jiu-Wu Bai, Jin-Fu Xu
BACKGROUND: Invasive pulmonary aspergillosis (IPA) is a fungal infection frequently observed in patients with immune dysfunction, such as those suffering from structural lung diseases. Nevertheless, studies assessing IPA combined with other common respiratory diseases remain scarce, particularly those regarding the immune status of its patients. Different structural lung diseases are known to differently affect patient immune status; however, the mechanisms by which this is conferred have yet to be determined...
February 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28272630/photocatalytic-h2-production-on-trititanate-nanotubes-coupled-with-cds-and-platinum-nanoparticles-under-visible-light-revisiting-h2-production-and-material-durability
#17
Hyunwoong Park, Hsin-Hung Ou, Minju Kim, Unseock Kang, Dong Suk Han, Michael R Hoffmann
The photocatalytic production of molecular hydrogen (H2) on ternary composites of Pt, CdS, and sodium trititanate nanotubes (NaxH2-xTi3O7, TNTs) is examined in an aqueous 2-propanol (IPA) solution (typically 5 vol%) at a circum-neutral pH under visible light (λ > 420 nm). The H2 production rates are dependent on the Pt-loading level, and the optimum production rate in the Pt/CdS/TNTs is approximately six times higher than that in Pt/CdS/TiO2. A D2O solution containing 5 vol% IPA leads only to the production of D2 molecules, whereas increasing the IPA amount to 30 vol% leads to the production of DH molecules...
March 8, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28267551/quantitative-ct-analysis-of-pulmonary-pure-ground-glass-nodule-predicts-histological-invasiveness
#18
Qiong Li, Li Fan, En-Tao Cao, Qing-Chu Li, Ya-Feng Gu, Shi Yuan Liu
OBJECTIVE: To assess whether quantitative computed tomography (CT) can help predict histological invasiveness of pulmonary adenocarcinoma appearing as pure ground glass nodules (pGGNs). METHODS: A total of 110 pulmonary pGGNs were retrospectively evaluated, and pathologically classified as pre-invasive lesions, minimally invasive adenocarcinoma (MIA) and invasive pulmonary adenocarcinoma (IPA). Maximum nodule diameters, largest cross-sectional areas, volumes, mean CT values, weights, and CT attenuation values at the 0th,2th,5th, 25th, 50th,75th, 95th, 98th and100th percentiles on histogram, as well as 2th to 98th, 5th to 95th, 25th to 75th,and 0th to 100thslopes, respectively, were compared among the three groups...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28255147/intrapancreatic-accessory-spleen-an-eluding-diagnosis
#19
K H Teoh, S Balraj, S R Navarasi
Intrapancreatic accessory spleen (IPAS) is a benign anomaly of splenic embryology and a rare cause of pancreatic pseudotumour. Here, we report a case of a 70-year-old Malay lady whose IPAS was discovered incidentally during her surveillance computed tomography for her underlying left lower lung fibrosis. Radiologically, the lesion mimicked a neuroendocrine pancreatic tumour and was only diagnosed pathologically as IPAS after surgery. In conclusion, recognising IPAS as a differential for enhancing pancreatic mass allows us to exhaust all non-invasive diagnostic means to diagnose this benign lesion...
February 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28246513/variations-in-the-origin-of-inferior-phrenic-arteries-and-their-relationship-to-celiac-axis-variations-on-ct-angiography
#20
Ramazan Aslaner, Yeliz Pekcevik, Hilal Sahin, Onur Toka
OBJECTIVE: Knowing the origin of the inferior phrenic artery (IPA) is important prior to surgical interventions and interventional radiological procedures related to IPA. We aimed to identify variations in the origin of IPA and to investigate the relationship between the origin of IPA and celiac axis variations using computed tomography angiography (CTA). MATERIALS AND METHODS: The CTA images of 1000 patients (737 male and 263 female, the mean age 60, range 18-94 years) were reviewed in an analysis of IPA and celiac axis variations...
March 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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