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https://www.readbyqxmd.com/read/29351304/evolutionary-algorithm-based-heuristic-scheme-for-nonlinear-heat-transfer-equations
#1
Azmat Ullah, Suheel Abdullah Malik, Khurram Saleem Alimgeer
In this paper, a hybrid heuristic scheme based on two different basis functions i.e. Log Sigmoid and Bernstein Polynomial with unknown parameters is used for solving the nonlinear heat transfer equations efficiently. The proposed technique transforms the given nonlinear ordinary differential equation into an equivalent global error minimization problem. Trial solution for the given nonlinear differential equation is formulated using a fitness function with unknown parameters. The proposed hybrid scheme of Genetic Algorithm (GA) with Interior Point Algorithm (IPA) is opted to solve the minimization problem and to achieve the optimal values of unknown parameters...
2018: PloS One
https://www.readbyqxmd.com/read/29351046/young-adults-experience-of-appearance-altering-orthognathic-surgery-a-longitudinal-interpretative-phenomenologic-analysis
#2
Morna J Liddle, Sarah R Baker, Keith G Smith, Andrew R Thompson
OBJECTIVE: To gain an experiential account of the processes of change associated specifically with orthognathic surgery. DESIGN: A qualitative design was used. Semistructured interviews were carried out with 7 participants approximately 1 week before and 6-8 weeks after surgery. The data were analyzed using interpretative phenomenologic analysis (IPA). SETTING: Participants were recruited from a NHS Dental Hospital. PARTICIPANTS: Patients aged 16 to 25 years scheduled to undergo orthognathic surgery on both the upper and lower jaws were purposively sought to participate...
February 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29345255/pure-mechanistic-analysis-of-additive-neuroprotective-effects-between-baicalin-and-jasminoidin-in-ischemic-stroke-mice
#3
Peng-Qian Wang, Qiong Liu, Wen-Juan Xu, Ya-Nan Yu, Ying-Ying Zhang, Bing Li, Jun Liu, Zhong Wang
Both baicalin (BA) and jasminoidin (JA) are active ingredients in Chinese herb medicine Scutellaria baicalensis and Fructus gardeniae, respectively. They have been shown to exert additive neuroprotective action in ischemic stroke models. In this study we used transcriptome analysis to explore the pure therapeutic mechanisms of BA, JA and their combination (BJ) contributing to phenotype variation and reversal of pathological processes. Mice with middle cerebral artery obstruction were treated with BA, JA, their combination (BJ), or concha margaritifera (CM)...
January 18, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29344347/epigenetic-alterations-in-tramp-mice-epigenome-dna-methylation-profiling-using-medip-seq
#4
Wenji Li, Ying Huang, Davit Sargsyan, Tin Oo Khor, Yue Guo, Limin Shu, Anne Yuqing Yang, Chengyue Zhang, Ximena Paredes-Gonzalez, Michael Verzi, Ronald P Hart, Ah-Ng Kong
Purpose: We investigated the genomic DNA methylation profile of prostate cancer in transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer model and to analyze the crosstalk among targeted genes and the related functional pathways. Methods: Prostate DNA samples from 24-week-old TRAMP and C57BL/6 male mice were isolated. The DNA methylation profiles were analyzed by methylated DNA immunoprecipitation (MeDIP) followed by next-generation sequencing (MeDIP-seq)...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29343867/improving-survival-of-acute-on-chronic-liver-failure-patients-complicated-with-invasive-pulmonary-aspergillosis
#5
Jie Gao, Qing Zhang, Yuankui Wu, Ying Li, Tingting Qi, Congyan Zhu, Sijia Liu, Ruoxi Yu, Qinjun He, Weiqun Wen, Fuyuan Zhou, Yongpeng Chen, Jinjun Chen, Jinlin Hou
The mortality of acute-on-chronic liver failure (ACLF) patients complicated with invasive pulmonary aspergillosis (IPA) was extremely high. We aimed to explore prognostic value of the Chronic Liver Failure-Sequential Organ Failure Assessment (CLIF-SOFA) lung score and to establish an optimal voriconazole regimen for ACLF patients complicated with IPA. We retrospectively screened hospitalized ACLF patients in our hospital from July 2011 to April 2016, from which 20 probable IPA cases were diagnosed. Along with onsets of IPA, deteriorated diseases severity, especially lung conditions were found in those 20 ACLF patients...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343062/tailored-waveform-of-dielectric-barrier-discharge-to-control-composite-thin-film-morphology
#6
Paul Brunet, Rocío Rincón, Zineb Matouk, Mohamed Chaker, Françoise Massines
Nanocomposite thin films formed of TiO2 in a polymer-like matrix are grown in a filamentary Argon (Ar) Dielectric Barrier Discharge (DBD) from a suspension of TiO2 nanoparticles in isopropanol (IPA). The sinusoidal voltage producing the plasma is designed to independently control the matrix growth rate and the transport of nanoparticles (NPs) aggregates to the surface. The useful FSK (Frequency Shift Keying) modulation mode is chosen to successively generate two sinusoidal voltages: a high frequency signal at 15 kHz and a low frequency signal at frequencies ranging from 0...
January 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29337425/distinct-gene-expression-profiles-and-regulation-networks-of-nasal-polyps-in-eosinophilic-and-non-eosinophilic-chronic-rhinosinusitis
#7
Naoko Okada, Tsuguhisa Nakayama, Daiya Asaka, Natsuki Inoue, Tadao Tsurumoto, Shinya Takaishi, Nobuyoshi Otori, Hiromi Kojima, Akio Matsuda, Keisuke Oboki, Hirohisa Saito, Kenji Matsumoto, Mamoru Yoshikawa
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is known to have 2 phenotypes in East Asia. Eosinophilic CRSwNP (ECRSwNP), defined as tissue eosinophilia and easily recurrent, is distinguished from other non-eosinophilic CRSwNP (NECRSwNP) types. However, the pathogenesis of each remains unclear. METHODS: Nasal polyp tissues from ECRS (ECRSwNP) and NECRS (NECRSwNP) patients were obtained, and their comprehensive gene expression profiles were investigated by microarray analysis...
January 16, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29333407/the-limited-role-of-serum-galactomannan-assay-in-screening-for-invasive-pulmonary-aspergillosis-in-allogeneic-stem-cell-transplantation-recipients-on-micafungin-prophylaxis-a-retrospective-study
#8
Ryul Kim, Youngil Koh, Dong-Yeop Shin, Pyoeng Gyun Choe, Nam Joong Kim, Sung-Soo Yoon, Myoung-Don Oh, Wan Beom Park, Inho Kim
Background: We evaluated the outcomes of serum galactomannan (GM) assay for the screening of invasive pulmonary aspergillosis (IPA) in allogeneic hematopoietic stem cell transplantation (alloHSCT) recipients while on primary antifungal prophylaxis (PAP). Methods: This study included patients with hematologic disorders who underwent alloHSCT from January 2013 to November 2015. Patients received routine PAP with fluconazole before 2014 and micafungin after 2014; serum GM tests were performed and retrospectively analyzed...
December 2017: Blood Research
https://www.readbyqxmd.com/read/29332534/mediated-effects-of-coping-on-mental-health-outcomes-of-african-american-women-exposed-to-physical-and-psychological-abuse
#9
Chmaika P Mills, Hope M Hill, Joshua A D Johnson
Few studies have assessed the individual symptoms of posttraumatic stress disorder (PTSD) as separate mental health consequences of intimate partner abuse (IPA). This study examined the role of coping strategies associated with symptoms of PTSD in a community sample of African American women who have experienced abuse ( N = 128). The results revealed that nonphysical abuse was more prevalent than physical abuse. Specific symptoms of PTSD expressed depended on the type of abuse experienced and the type of coping strategies utilized...
February 2018: Violence Against Women
https://www.readbyqxmd.com/read/29328941/production-of-mono-to-few-layer-mos2-nanosheets-in-isopropanol-by-a-salt-assisted-direct-liquid-phase-exfoliation-method
#10
Huaizhi Liu, Liao Xu, Weixu Liu, Bo Zhou, Yinyan Zhu, Lihua Zhu, Xiaoqing Jiang
Here, we report a facile salt-assisted direct liquid-phase exfoliation method for mass production of MoS2 nanosheets. We choose organic solvent isopropanol (IPA) as exfoliation media and potassium ferrocyanide, potassium sodium tartrate, or sodium tartrate as salt, the assistant. The selected salts show universal and efficient assistant effect for the exfoliation of MoS2 in IPA. Especially, potassium ferrocyanide (K4Fe(CN)6) can enhance the exfoliation efficiency up to 73 times and a dispersion of MoS2 nanosheets with concentration as high as 0...
January 6, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29325011/cognitive-complaints-in-memory-clinic-patients-and-in-depressive-patients-an-interpretative-phenomenological-analysis
#11
Lisa Miebach, Steffen Wolfsgruber, Ingo Frommann, Klaus Fließbach, Frank Jessen, Rachel Buckley, Michael Wagner
Background and Objectives: Cognitive complaints are discussed as early signs of Alzheimer's disease (AD). However, they are also very common in cognitively normal older adults and in patients with depression. Qualitative, interview-based approaches might be useful to identify those features of cognitive complaints specific for the experiences of cognitive decline in preclinical or prodromal AD versus those complaints typically reported by depressed patients. Research Design and Methods: A semi-structured interview was administered to 21 cognitively normal older adults (HC), 18 nondemented memory clinic patients (MC), and 11 patients with a major depression (MD), all above 55 years...
January 8, 2018: Gerontologist
https://www.readbyqxmd.com/read/29321553/prediction-of-co-expression-genes-and-integrative-analysis-of-gene-microarray-and-proteomics-profile-of-keshan-disease
#12
Sen Wang, Rui Yan, Bin Wang, Peiru Du, Wuhong Tan, Mikko J Lammi, Xiong Guo
Keshan disease (KD) is a kind of endemic cardiomyopathy which has a high mortality. However, molecular mechanism in the pathogenesis of KD remains poorly understood. Serum samples were collected from 112 KD patients and 112 normal controls. Gene microarray was used to screen differently expressed genes. Genevestigator was applied to forecast co-expression genes of significant gene. iTRAQ proteomics analysis was used to verify significant genes and their co-expression genes. GO, COG, IPA and STRING were applied to undertake function categorization, pathway and network analysis separately...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321036/maternal-engineered-nanomaterial-inhalation-during-gestation-alters-the-fetal-transcriptome
#13
P A Stapleton, Q A Hathaway, C E Nichols, A B Abukabda, M V Pinti, D L Shepherd, C R McBride, J Yi, V C Castranova, J M Hollander, T R Nurkiewicz
BACKGROUND: The integration of engineered nanomaterials (ENM) is well-established and widespread in clinical, commercial, and domestic applications. Cardiovascular dysfunctions have been reported in adult populations after exposure to a variety of ENM. As the diversity of these exposures continues to increase, the fetal ramifications of maternal exposures have yet to be determined. We, and others, have explored the consequences of ENM inhalation during gestation and identified many cardiovascular and metabolic outcomes in the F1 generation...
January 10, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29319429/distinctive-psychological-and-social-experiences-of-women-choosing-prophylactic-oophorectomy-for-cancer-prevention
#14
Rachel Meadows, Tasleem J Padamsee, Electra D Paskett
Women known to have significantly elevated ovarian cancer risk due to genetic mutations or family history can reduce this risk by surgically removing both ovaries and fallopian tubes (RRBSO, risk-reducing bilateral salpingo-oophorectomy). We used interpretive phenomenological analysis (IPA) to explore the psychosocial experiences of women who chose RRBSO for cancer prevention. We extended the traditional use of IPA to compare the experiences of women who chose RRBSO for cancer prevention to those of women who underwent similar gynecologic surgery for benign indications...
January 10, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29317699/inflammatory-proteomic-network-analysis-of-statin-treated-and-lipopolysaccharide-activated-macrophages
#15
Abu Hena M Kamal, Jayanta K Chakrabarty, S M Nashir Udden, Md Hasan Zaki, Saiful M Chowdhury
A significant component of immune biology research is the investigation of protein encoding genes that play central roles in contributing inflammatory response. A gel-free quantitative bottom-up proteomics study was performed on immune cell macrophages after the combined treatment of lipopolysaccharide (LPS) and statin drugs using mass spectrometry and a detailed bioinformatics analyses were conducted. Systematic bioinformatics analysis was applied for discovering novel relationships among proteins and effects of statin and lipopolysaccharide in macrophage cells...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29313870/aerobic-capacity-explains-physical-functioning-and-participation-in-patients-with-multiple-sclerosis-related-fatigue
#16
Emma Rosalie Driehuis, Lizanne Eva van den Akker, Vincent de Groot, Heleen Beckerman
OBJECTIVE: To investigate whether aerobic capacity explains the level of self-reported physical activity, physical functioning, and participation and autonomy in daily living in persons with multiple sclerosis-related fatigue. DESIGN: A cross-sectional study. PATIENTS: Sixty-two participants with multiple sclerosis-related fatigue. METHODS: Aerobic capacity was measured with a leg ergometer and was expressed as maximal oxygen uptake (VO2max, in ml/kg/min)...
January 9, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29304518/image-processing-and-analysis-of-mucosal-calretinin-staining-to-define-the-transition-zone-in-hirschsprung-disease-a-pilot-study
#17
Saleh Najjar, Sangtae Ahn, Israel Kasago, Chunlai Zuo, Kavita Umrau, Sanaz Ainechi, Christine Whyte, Christine E Sheehan, Suzanne M Homan, Hwajeong Lee
PURPOSE:  Quantification of calretinin-stained mucosal nerve fibers by image processing and analysis (IPA) may objectively define the transition zone (TZ) of Hirschsprung disease (HD). We tested the utility of IPA as an adjunctive tool in HD. MATERIALS AND METHODS:  Calretinin immunostain was performed on 15 HD pull-through specimens, and multiple images were captured from the proximal aganglionic zone, TZ, and probable normal zone (NZ). Pixel count (PC), defined as the percentage of brown-stained pixels in the mucosa, was quantified and plotted against distance from the rectal distal end...
January 5, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29303852/interpositional-arthroplasty-by-temporalis-fascia-flap-and-galea-aponeurotica-combined-with-distraction-osteogenesis-a-modified-method-in-treatment-of-adult-patients-with-temporomandibular-joint-ankylosis-and-mandibular-dysplasia
#18
Jia Qiao, Bing Yu, Lai Gui, Xi Fu, Chung-Kwan Yen, Feng Niu, Huijun Zhang, Cai Wang, Ying Chen, Meng Wang, Jianfeng Liu
BACKGROUND: Interpositional arthroplasty (IPA) with temporalis fascia flap has been one of the most frequently performed procedures to treat temporomandibular joint (TMJ) ankylosis. However, recurrence often occurs when the flap lacks bulk or atrophies. Whether to perform IPA or distraction osteogenesis (DO) first has long been a controversial issue when patients presented mandibular dysplasia (MD). This study provided IPA a new graft material sufficient to prevent recurrence, combined the modified protocol of performing DO 6 months after IPA, and evaluated its efficacy in treating TMJ ankylosis patients with MD...
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29302084/current-practices-in-hosting-non-us-pharmacy-students-at-us-pharmacy-schools-in-experiential-clerkships
#19
REVIEW
Sara Al-Dahir, Naser Z Alsharif, Shaun E Gleason, Toyin Tofade, Emily K Flores, Michael Katz, Emily K Dornblaser
Objective: To provide specific considerations for hosting non-U.S. pharmacy students at U.S.-based colleges/schools of pharmacy (C/SOP) for experiential clerkships and training. Findings: A literature review (2000-2016) in PubMed, Google Scholar and IPA databases was conducted using specific keywords. Recommendations and future directions for development of experiential rotations for non-U.S. students in U.S. experiential rotations are presented for both the home and host country. Summary articles and best practices across the disciplines, as well as expert opinion, were found across U...
November 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29301248/differences-in-the-plasma-proteome-of-patients-with-hypothyroidism-before-and-after-thyroid-hormone-replacement-a-proteomic-analysis
#20
Assim A Alfadda, Hicham Benabdelkamel, Afshan Masood, Anwar A Jammah, Aishah A Ekhzaimy
Thyroid hormone is a potent stimulator of metabolism, playing a critical role in regulating energy expenditure and in key physiological mechanisms, such as growth and development. Although administration of thyroid hormone in the form of levo thyroxine (l-thyroxine) has been used to treat hypothyroidism for many years, the precise molecular basis of its physiological actions remains uncertain. Our objective was to define the changes in circulating protein levels that characterize alterations in thyroid hormone status...
January 1, 2018: International Journal of Molecular Sciences
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