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https://www.readbyqxmd.com/read/28239531/brain-structure-working-memory-and-response-inhibition-in-childhood-leukemia-survivors
#1
Ellen van der Plas, Russell J Schachar, Johann Hitzler, Jennifer Crosbie, Sharon L Guger, Brenda J Spiegler, Shinya Ito, Brian J Nieman
INTRODUCTION: Survival rates for children with acute lymphoblastic leukemia (ALL) approach 95%. At the same time, there is growing concern that chemotherapy causes alterations in brain development and cognitive abilities. We performed MRI measurements of white and gray matter volume to explore how variation in brain structure may be related to cognitive abilities in ALL survivors and healthy controls. METHODS: The sample included 24 male ALL survivors who had completed contemporary treatment 3-11 years prior, and 21 age- and sex-matched controls...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239524/pattern-of-gray-matter-volumes-related-to-retinal-thickness-and-its-association-with-cognitive-function-in-relapsing-remitting-ms
#2
Jan-Patrick Stellmann, Hanife Cetin, Kim Lea Young, Sibylle Hodecker, Jana Pöttgen, Diana Bittersohl, Andrea Hassenstein, Timm Oberwahrenbrock, Christoph Heesen, Susanne Siemonsen
BACKGROUND: Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated. OBJECTIVE: To investigate the association between focal cortical volume and thickness of retinal layers...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28239512/exploring-the-continuum-of-vaccine-hesitancy-between-african-american-and-white-adults-results-of-a-qualitative-study
#3
Sandra Quinn, Amelia Jamison, Donald Musa, Karen Hilyard, Vicki Freimuth
Vaccine delay and refusal present very real threats to public health. Since even a slight reduction in vaccination rates could produce major consequences as herd immunity is eroded, it is imperative to understand the factors that contribute to decision-making about vaccines. Recent scholarship on the concept of "vaccine hesitancy" emphasizes that vaccine behaviors and beliefs tend to fall along a continuum from refusal to acceptance. Most research on hesitancy has focused on parental decision-making about childhood vaccines, but could be extended to explore decision-making related to adult immunization against seasonal influenza...
December 29, 2016: PLoS Currents
https://www.readbyqxmd.com/read/28239471/gene-expression-markers-of-tumor-infiltrating-leukocytes
#4
Patrick Danaher, Sarah Warren, Lucas Dennis, Leonard D'Amico, Andrew White, Mary L Disis, Melissa A Geller, Kunle Odunsi, Joseph Beechem, Steven P Fling
BACKGROUND: Assays of the abundance of immune cell populations in the tumor microenvironment promise to inform immune oncology research and the choice of immunotherapy for individual patients. We propose to measure the intratumoral abundance of various immune cell populations with gene expression. In contrast to IHC and flow cytometry, gene expression assays yield high information content from a clinically practical workflow. Previous studies of gene expression in purified immune cells have reported hundreds of genes showing enrichment in a single cell type, but the utility of these genes in tumor samples is unknown...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28238738/reference-standard-space-hippocampus-labels-according-to-the-eadc-adni-harmonized-protocol-utility-in-automated-volumetry
#5
Dominik Wolf, Martina Bocchetta, Gregory M Preboske, Marina Boccardi, Michel J Grothe
BACKGROUND: A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. METHODS: Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels...
February 23, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28238732/ghrelin-and-cancer-progression
#6
REVIEW
Tsung-Chieh Lin, Michael Hsiao
Ghrelin is a small peptide with 28 amino acids, and has been characterized as the ligand of the growth hormone secretagogue receptor (GHSR). In addition to its original function in stimulating pituitary growth hormone release, ghrelin is multifunctional which plays role in the regulation of energy balance, gastric acid release, appetite, insulin secretion, gastric motility and the turnover of gastric and intestinal mucosa. The discovery of ghrelin and GHSR expression beyond normal tissues suggests its role other than physiological function...
February 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28237701/regulator-of-g-protein-signaling-20-correlates-with-clinicopathological-features-and-prognosis-in-triple-negative-breast-cancer
#7
Quan Li, Wenxu Jin, Yefeng Cai, Fang Yang, Endong Chen, Danrong Ye, Qingxuan Wang, Xiaoxiang Guan
Triple-negative breast cancer (TNBC) is a highly aggressive tumor subtype lacking effective prognostic indicators or therapeutic targets. Therefore, finding a novel molecular biomarker for TNBC to achieve target therapy and predict its prognosis is crucial in preventing inappropriate treatment. Regulator of G-protein signaling (RGS) families of protein can negatively regulate signaling of heterotrimeric G proteins and are known to be upregulated in various tumors. In this study, we demonstrated that RGS20 was more highly expressed in TNBC tumor tissue than in adjacent normal tissue by analyzing the cancer genome atlas (TCGA) database...
February 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28237646/recurrence-associated-genes-in-papillary-thyroid-cancer-an-analysis-of-data-from-the-cancer-genome-atlas
#8
Ming-Nan Chien, Po-Sheng Yang, Jie-Jen Lee, Tao-Yeuan Wang, Yi-Chiung Hsu, Shih-Ping Cheng
BACKGROUND: Recurrence of papillary thyroid cancer is not uncommon, but incorporating clinicopathologic parameters to predict recurrence is suboptimal. The aim of this study was to identify systemically recurrence-associated genes using The Cancer Genome Atlas RNA sequencing database. METHODS: A total of 504 patients with transcriptome sequencing data of the primary neoplasm were included in this study. High and low levels of expression of each gene were defined by median splits...
February 22, 2017: Surgery
https://www.readbyqxmd.com/read/28237561/evolution-of-endoscopic-treatment-of-sleeve-gastrectomy-leaks-from-partially-covered-to-long-fully-covered-stents
#9
Fabio Garofalo, Maxime Noreau-Nguyen, Ronald Denis, Henri Atlas, Pierre Garneau, Radu Pescarus
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) has become a widely accepted option in the treatment of morbid obesity. Gastric leaks after SG occur in .9%-2.2% of the patients, mostly at the gastroesophageal junction. The current treatment algorithm includes drainage, antibiotics, nutritional support, and endoluminal control. OBJECTIVES: Our hypothesis is that long, fully covered stents represent a safe, effective solution for SG leaks. SETTING: University hospital...
December 26, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28236887/ajkd-atlas-of-renal-pathology-nephrocalcinosis-and-acute-phosphate-nephropathy
#10
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
March 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28236886/ajkd-atlas-of-renal-pathology-2-8-dihydroxyadeninuria
#11
Mark A Lusco, Agnes B Fogo, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
March 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28236885/ajkd-atlas-of-renal-pathology-oxalosis
#12
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
March 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28235761/high-throughput-genomic-profiling-of-adult-solid-tumors-reveals-novel-insights-into-cancer-pathogenesis
#13
Ryan J Hartmaier, Lee Albacker, Juliann Chmielecki, Mark Bailey, Jie He, Michael Goldberg, Shakti Ramkissoon, James Suh, Julia A Elvin, Samuel Chiacchia, Garrett M Frampton, Jeffrey S Ross, Vincent Miller, Philip J Stephens, Doron Lipson
Genomic profiling is widely predicted to become a standard of care in clinical oncology, but more effective data sharing to accelerate progress in precision medicine will be required. Here we describe cancer-associated genomic profiles from 18,004 unique adult cancers. The dataset was composed of 162 tumor subtypes including multiple rare and uncommon tumors. Comparison of alteration frequencies to The Cancer Genome Atlas (TCGA) identified some differences and suggested an enrichment of treatment-refractory samples in breast and lung cancer cohorts...
February 24, 2017: Cancer Research
https://www.readbyqxmd.com/read/28235680/apoe-%C3%AE%C2%B54-status-is-associated-with-white-matter-hyperintensities-volume-accumulation-rate-independent-of-ad-diagnosis
#14
Carole H Sudre, M Jorge Cardoso, Chris Frost, Josephine Barnes, Frederik Barkhof, Nick Fox, Sébastien Ourselin
To assess the relationship between carriage of APOE ε4 allele and evolution of white matter hyperintensities (WMHs) volume, we longitudinally studied 339 subjects from the Alzheimer's Disease Neuroimaging Initiative cohort with diagnoses ranging from normal controls to probable Alzheimer's disease (AD). A purpose-built longitudinal automatic method was used to segment WMH using constraints derived from an atlas-based model selection applied to a time-averaged image. Linear mixed models were used to evaluate the differences in rate of change across diagnosis and genetic groups...
January 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28231410/transcriptomic-analyses-of-rna-binding-proteins-reveal-eif3c-promotes-cell-proliferation-in-hepatocellular-carcinoma
#15
Tangjian Li, Shengli Li, Di Chen, Bing Chen, Tao Yu, Fangyu Zhao, Qifeng Wang, Ming Yao, Shenglin Huang, Zhiao Chen, Xianghuo He
RNA-binding proteins (RBPs) play fundamental roles in the RNA life cycle. The aberrant expression of RBPs is often observed in human disease, including cancer. In this study, we screened for the expression levels of 1,542 human RBPs in The Cancer Genome Atlas liver hepatocellular carcinoma (TCGA LIHC) samples and found 92 consistently up-regulated RBP genes in HCC compared with normal samples. Additionally, we performed a Kaplan-Meier analysis and found that high expression of 15 RBP genes was associated with poor prognosis in patients with HCC...
February 23, 2017: Cancer Science
https://www.readbyqxmd.com/read/28231063/bone-age-in-unilateral-spastic-cerebral-palsy-is-there-a-correlation-with-hand-function-and-limb-length
#16
Je-Sang Lee, Im Jeong Choi, Myung Jun Shin, Jin-A Yoon, Sung Hwa Ko, Yong Beom Shin
BACKGROUND: The purpose of this study was to analyze the bone age and the upper extremity segmental lengths between the affected and the unaffected side and to reveal the correlation between the difference of bone age and the upper limb length discrepancy in the unilateral spastic cerebral palsy (CP). We also evaluated the relationship between difference of bone age and hand function. METHODS: Seventy-eight patients participated in this study. The bone ages of hand-wrists of the patients were determined by the Greulich and Pyle atlas...
February 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28230575/patients-and-care-partners-perspectives-on-dignity-and-respect-during-acute-care-hospitalization
#17
Priscilla K Gazarian, Constance R C Morrison, Lisa Soleymani Lehmann, Orly Tamir, David W Bates, Ronen Rozenblum
BACKGROUND: Delivering patient-centered care (PCC) is essential to our healthcare system. Patient dignity and respect are foundational elements of PCC. Understanding patients' and their care partner's perspectives on the meaning of dignity and respect within a clinical care environment is critical to achieving our goal of PCC. OBJECTIVE: The aim of the study was to understand how patients and their care partners define, describe, and experience dignity and respect during hospitalization...
February 22, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28230069/consistent-role-of-quaternary-climate-change-in-shaping-current-plant-functional-diversity-patterns-across-european-plant-orders
#18
Alejandro Ordonez, Jens-Christian Svenning
Current and historical environmental conditions are known to determine jointly contemporary species distributions and richness patterns. However, whether historical dynamics in species distributions and richness translate to functional diversity patterns remains, for the most part, unknown. The geographic patterns of plant functional space size (richness) and packing (dispersion) for six widely distributed orders of European angiosperms were estimated using atlas distribution data and trait information. Then the relative importance of late-Quaternary glacial-interglacial climate change and contemporary environmental factors (climate, productivity, and topography) as determinants of functional diversity of evaluated orders was assesed...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28227988/liver-segmentation-using-location-and-intensity-probabilistic-atlases
#19
Negar Farzaneh, Shadrokh Samavi, S M Reza Soroushmehr, Hirenkumar Patel, Samuel Habbo-Gavin, David Paul Fessell, Kevin R Ward, Kayvan Najarian, Negar Farzaneh, Shadrokh Samavi, S M Reza Soroushmehr, Hirenkumar Patel, Samuel Habbo-Gavin, David Paul Fessell, Kevin R Ward, Kayvan Najarian, Kevin R Ward, S M Reza Soroushmehr, Hirenkumar Patel, Shadrokh Samavi, Samuel Habbo-Gavin, Kayvan Najarian, David Paul Fessell, Negar Farzaneh
In a variety of injuries and illnesses, internal organs in the abdominal and pelvic regions, in particular liver, may be compromised. In the current practice, CT scans of liver are visually inspected to investigate the integrity of the organ. However, the size and complexity of the CT images limits the reliability of visual inspection to accurately assess the health of liver. Computer-aided image analysis can create fast and quantitative assessment of liver from the CT, in particular in the environments where access to skilled radiologists may be limited...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227881/a-framework-for-informing-segmentation-of-in-vivo-mri-with-information-derived-from-ex-vivo-imaging-application-in-the-medial-temporal-lobe
#20
Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk, Paul A Yushkevich, Laura Wisse, Daniel Adler, Ranjit Ittyerah, John B Pluta, John L Robinson, Theresa Schuck, John Q Trojanowski, Murray Grossman, John A Detre, Mark A Elliott, Jon B Toledo, Weixia Liu, Stephen Pickup, Sandhitsu R Das, David A Wolk, John L Robinson, Jon B Toledo, Stephen Pickup, Weixia Liu, Paul A Yushkevich, Daniel Adler, John Q Trojanowski, Theresa Schuck, David A Wolk, Laura Wisse, Mark A Elliott, Sandhitsu R Das, John A Detre, John B Pluta, Ranjit Ittyerah, Murray Grossman
Automatic segmentation of cortical and subcortical structures is commonplace in brain MRI literature and is frequently used as the first step towards quantitative analysis of structural and functional neuroimaging. Most approaches to brain structure segmentation are based on propagation of anatomical information from example MRI datasets, called atlases or templates, that are manually labeled by experts. The accuracy of automatic segmentation is usually validated against the "bronze" standard of manual segmentation of test MRI datasets...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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