Duo Li, Yuansen Chen, Bofan Yang, Wenli Li, Yang Xu, Xiangyu Wang, Yanjiao Teng, Yu Luo, Chunli Liu, Jie Shi, Xiaoqin Guo, Yanqing Liu, Qi Lv, Haojun Fan
METHODS: Using a self-developed multi-channel intelligent small-animal crush injury platform, we applied a force of 5 kg to the hind limbs of 8-week-old rats (280-300 g), subjecting them to a continuous 12 h compression to establish the CS model. Continuous monitoring was conducted for both the lower limbs and the overall body status. Following decompression, biochemical samples were collected at 3 h, 6 h, 12 h, and 24 h. In addition, we created a CS model after resection of the left kidney (UNx-CS) which was conceptualized to simulate a more challenging clinical scenario to investigate the physiological and pathological responses rats with renal insufficiency combined with crush injury...
November 22, 2023: Shock