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https://www.readbyqxmd.com/read/28109116/aminoaciduria-caused-by-fanconi-syndrome-in-a-heifer
#1
N Cesbron, L Dorso, A-L Royer, G Dervilly-Pinel, J Hervé
A case study of renal tubular dysfunction consistent with idiopathic Fanconi syndrome is reported in an 18-month-old Holstein heifer. The clinical, biochemical, and histopathological features are described. The heifer had clinical signs of growth retardation, wasting, and persistent diarrhea. Biochemical blood analysis identified hypokalemia, hyponatremia, and hypochloremia. Urinalysis identified glycosuria, proteinuria, and acidic pH. Histological examination of the kidney disclosed mild tubular necrosis with proteinaceous casts in the lumina of renal tubules...
January 21, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28101590/-minimally-invasive-treatment-of-intra-articular-calcaneal-fractures-with-the-2%C3%A2-point-distractor
#2
G Mattiassich, W Litzlbauer, M Ponschab, R Ortmaier, C Rodemund
OBJECTIVE: Open treatment of calcaneus fractures often has an increased risk of wound healing. Minimally invasive treatment with small incisions reduces complications. INDICATIONS: Calcaneal fractures with malalignment/comminution >1-2 mm; broadening, varus alignment of the calcaneal length axis or shortening; emergency surgery for open fractures or compartment syndrome. CONTRAINDICATIONS: Local or general contraindications. SURGICAL TECHNIQUE: Standardised positioning; restoration of length/axis with 2‑point distractor under fluoroscopic control...
January 18, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28089535/farmer-attitudes-and-perceptions-to-the-re-use-of-fertiliser-products-from-resource-oriented-sanitation-systems-the-case-of-vellore-south-india
#3
Prithvi Simha, Cecilia Lalander, Björn Vinnerås, M Ganesapillai
Relatively little research has been conducted to date on farmer attitudes towards the use of fertilisers from resource-oriented sanitation systems. This study employed a psycho-sociological approach to identify factors that encourage, or discourage, negative and positive attitudes to human waste recycling among farmers in southern India. A survey involving face-to-face interviews was performed with 120 randomly sampled farmers, taking into account the following factors: gender, age, religion, caste, type of farming, farm size, annual income and farming history...
January 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28067686/persistent-knee-pain-after-falling-off-of-a-bicycle
#4
Muhammad Waseem, Julissa Garrido-Joyce, Frances Quee, Soula Priovolos
We present the case of an 18-year-old young man with severe persistent knee pain secondary to a popliteal artery thrombosis. This occurred as a result of a fall from a bicycle. Acute compartment syndrome refers to the sequelae that can occur because of increased fascial compartment pressures, such as crush injuries, burns, traumatic or spontaneous hemorrhage, or constrictive casts. Increased pressures in nonelastic fascial compartments result in decreased perfusion distally, leading to ischemia of muscles and neurovascular tissue...
January 6, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28063872/eosinophilic-esophagitis-vs-proton-pump-inhibitor-responsive-esophageal-eosinophilia-transcriptome-analysis
#5
Tetsuo Shoda, Akio Matsuda, Ichiro Nomura, Naoko Okada, Kanami Orihara, Hironobu Mikami, Norihisa Ishimura, Shunji Ishihara, Kenji Matsumoto, Yoshikazu Kinoshita
Transcriptome analysis of eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia suggests these are a single syndrome, which casts doubt on the current guideline leading to the two distinct disease examinations according to PPI responses.
January 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28062308/spinal-reorganization-after-bone-fracture-in-mice
#6
Silke Hirsch, Alaa Ibrahim, Laura Krämer, Fabiola Escolano-Lozano, Tanja Schlereth, Frank Birklein
: Bone fracture with subsequent immobilization of the injured limb can cause Complex Regional Pain Syndrome (CRPS) in humans. Mechanisms of CRPS are still not completely understood but bone fracture with casting in mice leads to a similar posttraumatic inflammation as seen in humans and might therefore be an analogue to human CRPS. Here we report behavioral and spinal electrophysiological changes in mice that developed swelling of the paw, warming of the skin and pain in the injured limb after bone fracture...
January 3, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27998272/association-of-mitochondrial-dna-variants-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-symptoms
#7
Maureen R Hanson, Zhenglong Gu, Alon Keinan, Kaixiong Ye, Arnaud Germain, Paul Billing-Ross
Earlier this year, we described an analysis of mitochondrial DNA (mtDNA) variants in myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) patients and healthy controls. We reported that there was no significant association of haplogroups or singe nucleotide polymorphisms (SNPs) with disease status. Nevertheless, a commentary about our paper appeared (Finsterer and Zarrouk-Mahjoub. J Transl Med14:182, 2016) that criticized the association of mtDNA haplogroups with ME/CFS, a conclusion that was absent from our paper...
December 20, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27984689/-congenital-knee-dislocation-case-report
#8
C Arvinius, R Luque, C Díaz-Ceacero, F Marco
Congenital knee dislocation is an infrequent condition with unknown etiology. In some cases it occurs as an isolated condition, while in others it coexists with associated conditions or syndromes. The treatment of congenital knee dislocation is driven by the severity and flexibility of the deformity. The literature includes from serial casting or the Pavlik harness to quadriceps tendon plasty or femoral osteotomies. We report herein the case of a congenital dislocation treated with serial casting with a good outcome...
May 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/27942889/off-loading-strategies-in-diabetic-foot-syndrome-evaluation-of-different-devices
#9
Jürgen Götz, Mario Lange, Silvia Dullien, Joachim Grifka, Gernot Hertel, Clemens Baier, Franz Koeck
INTRODUCTION: Diabetic foot syndrome is one of the most dreaded complications in diabetes mellitus. The purpose of this study was to assess the value of different offloading devices compared to walking in barefoot condition and in normal shoes both in healthy subjects and in patients with diabetes and neuropathy. METHODS: Twenty patients with diabetes and polyneuropathy and ten healthy probands were included. Pedobarographic examination was performed in barefoot condition, with sneakers, postoperative shoes, Aircast® Diabetic Pneumatic Walker™ and VACO®diaped...
December 9, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27893637/timing-of-presentation-of-pediatric-compartment-syndrome-and-its-microsurgical-implication-a-retrospective-review
#10
Natalia I Ziolkowski, Leanne Zive, Emily Ho, Ronald Zuker
BACKGROUND: Forearm compartment syndrome in the pediatric population can lead to severe functional disability. Although it is known that earlier presentation with decompression leads to better outcomes, it is not known when presentation post-injury leads to significant loss of function requiring microsurgical intervention. AIM: To describe the rate of microsurgical reconstruction after forearm compartment syndrome in pediatric patients as related to timing of presentation...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27871159/-acute-kidney-injury-in-cirrhotic-patients-with-portal-hypertension
#11
REVIEW
So Mi Kim, Il Han Song
Acute kidney injury (AKI) is one of the most common manifestations encountered in clinical practice. It is associated with high morbidity and mortality in cirrhotic pre- and post-transplantation patients. Hepatorenal syndrome (HRS), a special form of AKI in cirrhotic patients, was recognized as a consequence of renal vasoconstriction from systemic/renal hemodynamic alterations developed in advanced cirrhosis with portal hypertension. Recently, multiple factors-such as infection/inflammation, underlying glomerulonephritis, bile cast, or increased abdominal pressure-have been considered to contribute to renal dysfunction in cirrhotic patients, which were presumed to induce HRS...
November 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27810088/the-promise-and-peril-of-precision-medicine-phenotyping-still-matters-most
#12
REVIEW
Jaeger P Ackerman, Daniel C Bartos, Jamie D Kapplinger, David J Tester, Brian P Delisle, Michael J Ackerman
We illustrate the work necessary to reverse course after identification of a KCNQ1 variant interpreted erroneously as causing long QT syndrome (LQTS) and to identify the true cause of a case of sudden death in the young. Surrogate genetic testing of a decedent's living brother identified a rare KCNQ1-V133I variant, which prompted an implantable cardioverter defibrillator and subsequent diagnosis of LQTS in other family members. Subsequently, this presumed LQT1 family came to our institution for further clinical evaluation and research-based investigations, including KCNQ1-V133I variant-specific analysis of the decedent, heterologous expression studies of KCNQ1-V133I, and a whole-exome molecular autopsy along with genomic triangulation using his unaffected parents' DNA...
October 8, 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27803913/factors-associated-with-recurrence-of-clubfoot-treated-by-the-ponseti-method
#13
Mohammad Reza Azarpira, Mohammad Jafar Emami, Amir Reza Vosoughi, Keivan Rahbari
AIM: To assess several associated factors on the recurrence of clubfoot after successful correction by the Ponseti method. METHODS: A total of 115 children with 196 clubfeet deformities, treated by the Ponseti method, were evaluated. Demographic data, family history of clubfoot in first-degree relatives, maternal educational level and brace compliance were enquired. Based on their medical files, the characteristics of the patients at the time of presentation such as age, possible associated neuromuscular disease or especial syndrome, severity of the deformity according to the Dimeglio grade and Pirani score, residual deformity after previous Ponseti method and number of casts needed for the correction were recorded...
October 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27803842/what-do-we-learn-from-the-murine-jacob-nsmf-gene-knockout-for-human-disease
#14
Christina Spilker, Katarzyna M Grochowska, Michael R Kreutz
Mutations in the NSMF gene have been related to Kallmann syndrome. Conflicting results have been reported on the subcellular localization of Jacob/NELF, the protein encoded by the NSMF gene. Some reports indicate an extracellular localization and a function as a guidance molecule for migration of GnRH-positive neurons from the olfactory placode to the hypothalamus. Other studies have shown protein transport of Jacob from synapse-to-nucleus and indicate a role of the protein in neuronal activity-dependent gene expression...
2016: Rare Diseases
https://www.readbyqxmd.com/read/27790943/casting-the-critical-regions-in-nucleotide-binding-oligomerization-domain-2-protein-a-signature-mediated-structural-dynamics-approach
#15
P Raghuraman, R Jesu Jaya Sudan, J Lesitha Jeeva Kumari, C Sudandiradoss
Nucleotide binding oligomerization domain 2 (NOD2), a protein involved in the first line defence mechanism has a pivotal role in innate immunity. Impaired function of this protein is implicated in disorders such as Blau syndrome and Crohn's disease. Since an altered function is linked to protein's structure, we framed a systematic strategy to interpret the structure-function relationship of the protein. Initiated with mutation-based pattern prediction and identified a distant ortholog (DO) of NOD2 from which the intra-residue interaction network was elucidated...
November 16, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27780576/bile-cast-nephropathy-caused-by-obstructive-cholestasis
#16
Julien Aniort, Anaïs Poyet, Jean-Louis Kemeny, Carole Philipponnet, Anne-Elisabeth Heng
Acute kidney injury (AKI) is a major complication in patients with liver disease. Although hepatorenal syndrome is frequently involved, bile cast nephropathy, characterized by tubular bile cast formation, has been scarcely described in the setting of severe liver failure. Few renal histology studies are available in these patients. We describe a case of bile cast nephropathy in a patient with obstructive cholestasis caused by stones in the common bile duct. The kidney biopsy confirmed this diagnosis, with several green casts in tubular lumens, tubular injury, and bilirubin composition of the tubular casts with Hall stain...
January 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27773721/identification-of-krt16-as-a-target-of-an-autoantibody-response-in-complex-regional-pain-syndrome
#17
Maral Tajerian, Victor Hung, Hamda Khan, Lauren J Lahey, Yuan Sun, Frank Birklein, Heidrun H Krämer, William H Robinson, Wade S Kingery, J David Clark
OBJECTIVE: Using a mouse model of complex regional pain syndrome (CRPS), our goal was to identify autoantigens in the skin of the affected limb. METHODS: A CRPS-like state was induced using the tibia fracture/cast immobilization model. Three weeks after fracture, hindpaw skin was homogenized, run on 2-d gels, and probed by sera from fracture and control mice. Spots of interest were analyzed by liquid chromatography-mass spectroscopy (LC-MS) and the list of targets validated by examining their abundance and subcellular localization...
January 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27753436/screening-for-celiac-disease-in-irritable-bowel-syndrome-an-updated-systematic-review-and-meta-analysis
#18
REVIEW
Andrew J Irvine, William D Chey, Alexander C Ford
OBJECTIVES: Celiac disease (CD) and irritable bowel syndrome (IBS) share similar symptoms, leading to confusion between the two and diagnostic delay. International guidelines recommend screening individuals with IBS for CD, via serological testing. However, studies published recently have cast doubt on the utility of this. We updated a previous meta-analysis examining this issue. METHODS: MEDLINE, EMBASE, and EMBASE Classic were searched through to May 2016. Eligible studies recruited adults with IBS according to symptom-based criteria, physician's opinion, or questionnaire data...
January 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27720052/ties-between-ageing-plasticity-and-reproductive-physiology-in-honey-bees-apis-mellifera-reveal-a-positive-relation-between-fecundity-and-longevity-as-consequence-of-advanced-social-evolution
#19
REVIEW
Olav Rueppell, Denise Aumer, Robin Fa Moritz
Honey bees (Apis mellifera) are the best studied model of ageing among the social insects. As in other social insects, the reproductive queen far outlives her non-reproductive workers despite developing from the same genome in the same colony environment. Thus, the different social roles of the two female castes are critical for the profound phenotypic plasticity. In several special cases, such as the reproductive workers of Apis mellifera capensis, within-caste plasticity enables further studies of the fecundity-longevity syndrome in honey bees...
August 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27694577/morphometric-covariation-between-palatal-shape-and-skeletal-pattern-in-children-and-adolescents-a-cross-sectional-study
#20
Eleni Parcha, Elias Bitsanis, Demetrios J Halazonetis
OBJECTIVE: To assess shape covariation of the palate and craniofacial complex (CFC) in children and adolescents. METHODS: Pre-treatment lateral cephalometric radiographs and corresponding maxillary casts of 100 children (8-10 years) and 100 adolescents (15-20 years) were digitized. Exclusion criteria were previous orthodontic treatment, craniofacial syndromes, mouth breathing, finger sucking, crossbite, tooth agenesis, and tooth impaction. Palatal shape was described with 239 surface and curve semilandmarks and craniofacial shape with 10 fixed landmarks and 117 curve semilandmarks...
September 30, 2016: European Journal of Orthodontics
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