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Schizophrenia and negative symptoms

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https://www.readbyqxmd.com/read/28213300/experiences-of-stigma-and-discrimination-faced-by-family-caregivers-of-people-with-schizophrenia-in-india
#1
Mirja Koschorke, R Padmavati, Shuba Kumar, Alex Cohen, Helen A Weiss, Sudipto Chatterjee, Jesina Pereira, Smita Naik, Sujit John, Hamid Dabholkar, Madhumitha Balaji, Animish Chavan, Mathew Varghese, R Thara, Vikram Patel, Graham Thornicroft
Stigma associated with schizophrenia significantly affects family caregivers, yet few studies have examined the nature and determinants of family stigma and its relationship to their knowledge about the condition. This paper describes the experiences and determinants of stigma reported by the primary caregivers of people living with schizophrenia (PLS) in India. The study used mixed methods and was nested in a randomised controlled trial of community care for people with schizophrenia. Between November 2009 and October 2010, data on caregiver stigma and functional outcomes were collected from a sample of 282 PLS-caregiver dyads...
February 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28212174/categorizing-and-assessing-negative-symptoms
#2
Paola Bucci, Silvana Galderisi
PURPOSE OF REVIEW: To provide a review on studies published in the last year relevant to the categorization and assessment of negative symptoms. RECENT FINDINGS: Recent research supported the validity of the 'deficit/non-deficit schizophrenia' categorization. Few studies confirmed the validity of the category 'persistent negative symptoms', whereas no recent study explored the validity of the category 'predominant negative symptoms'. The two-factor structure of the negative dimension is supported by studies reporting different correlates for the two subdomains: diminished expression and avolition/apathy...
February 15, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28209179/the-social-brain-network-in-22q11-2-deletion-syndrome-a-diffusion-tensor-imaging-study
#3
Amy K Olszewski, Zora Kikinis, Christie S Gonzalez, Ioana L Coman, Nikolaos Makris, Xue Gong, Yogesh Rathi, Anni Zhu, Kevin M Antshel, Wanda Fremont, Marek R Kubicki, Sylvain Bouix, Martha E Shenton, Wendy R Kates
BACKGROUND: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with a 25-fold increase in schizophrenia. Both individuals with 22q11.2DS and those with schizophrenia present with social cognitive deficits, which are putatively subserved by a network of brain regions that are involved in the processing of social cognitive information. This study used two-tensor tractography to examine the white matter tracts believed to underlie the social brain network in a group of 57 young adults with 22q11...
February 16, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28208190/real-world-effectiveness-of-antipsychotics-for-the-treatment-of-negative-symptoms-in-patients-with-schizophrenia-with-predominantly-negative-symptoms
#4
Diego Novick, William Montgomery, Tamas Treuer, Maria Victoria Moneta, Josep Maria Haro
This study assessed the comparative effectiveness of antipsychotics in the treatment of patients with schizophrenia presenting with prominent negative symptoms and no-to-mild positive symptoms. Data were taken from a 3-year prospective, international, observational study (n=17 384). This post-hoc study focused on 3 712 patients who started antipsychotic monotherapy and had moderate-to-severe negative symptoms and no-to-mild positive symptoms (Clinical Global Impression-Severity Scale [GGI-SCH]). Patients were classified into 3 treatment cohorts: olanzapine, other atypicals and typicals...
February 16, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28202261/hyperprolinemia-as-a-clue-in-the-diagnosis-of-a-patient-with-psychiatric-manifestations
#5
Marco Duarte, Joana Afonso, Ana Moreira, Diana Antunes, Cristina Ferreira, Hildeberto Correia, Margarida Marques, Sílvia Sequeira
Lately, microdeletions of the 22q region, responsible for DiGeorge syndrome or velocardiofacial syndrome, have been increasingly related to neuropsychiatric disorders including schizophrenia and bipolar disorder. These manifestations seem to be related to certain genes located in the hemideleted region such as the proline dehydrogenase (PRODH) and the catechol-o-methyltransferase (COMT) genes. We describe a teenager who started his adolescent psychiatric care presenting cognitive impairment, irritable mood and aggressive behaviour with schizophrenia-like symptoms that scored 153 in the Positive and Negative Symptoms Scale (PANSS) assessment...
February 12, 2017: Brain & Development
https://www.readbyqxmd.com/read/28202095/the-effects-of-vitamin-and-mineral-supplementation-on-symptoms-of-schizophrenia-a-systematic-review-and-meta-analysis
#6
J Firth, B Stubbs, J Sarris, S Rosenbaum, S Teasdale, M Berk, A R Yung
BACKGROUND: When used as an adjunctive with antipsychotics, certain vitamins and minerals may be effective for improving symptomatic outcomes of schizophrenia, by restoring nutritional deficits, reducing oxidative stress, or modulating neurological pathways. METHOD: We conducted a systematic review of all randomized controlled trials (RCTs) reporting effects of vitamin and/or mineral supplements on psychiatric symptoms in people with schizophrenia. Random-effects meta-analyses were used to calculate the standardized mean difference between nutrient and placebo treatments...
February 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28199911/the-prevalence-risk-factors-and-clinical-correlates-of-obesity-in-chinese-patients-with-schizophrenia
#7
Qiongzhen Li, Xiangdong Du, Yingyang Zhang, Guangzhong Yin, Guangya Zhang, Consuelo Walss-Bass, João Quevedo, Jair C Soares, Haishen Xia, Xiaosi Li, Yingjun Zheng, Yuping Ning, Xiang Yang Zhang
Obesity is a common comorbidity in schizophrenia. Few studies have addressed obesity in Chinese schizophrenia patients. The aims of this current study were to evaluate the prevalence, risk factors and clinical correlates of obesity in Chinese patients with schizophrenia. A total of 206 patients were recruited from a hospital in Beijing. Their clinical and anthropometric data together with plasma glucose and lipid parameters were collected. Positive and Negative Syndrome Scale (PANSS) was rated for all patients...
December 27, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28197005/p300-and-neuropsychological-measurements-in-patients-with-schizophrenia-and-their-healthy-biological-siblings
#8
D Vijaya Raghavan, Arumugam Shanmugiah, P Bharathi, Ramasamy Jeyaprakash
BACKGROUND: Patients with schizophrenia and their first-degree relatives' exhibit abnormalities in neuropsychological and electrophysiological measures especially P300. The aim was to study the P300 and neuropsychological measures together in patients with schizophrenia, their unaffected siblings, and normal controls. MATERIALS AND METHODS: Thirty patients diagnosed as schizophrenia, their unaffected biological siblings, and normal controls were included in the study...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28193583/nicotinic-modulation-of-salience-network-connectivity-and-centrality-in-schizophrenia
#9
Jason Smucny, Korey P Wylie, Eugene Kronberg, Kristina T Legget, Jason R Tregellas
Although functional abnormalities of the salience network are associated with schizophrenia, the acute effects of nicotine on its function and network dynamics during the resting state in patients are poorly understood. In this study, the effects of a 7 mg nicotine patch (vs. placebo) on salience network connectivity were examined in 17 patients with schizophrenia and 19 healthy subjects. We hypothesized abnormal connectivity between the salience network and other major networks (e.g. executive network) in patients under placebo administration and amelioration of this difference after nicotine...
February 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28192770/the-relationship-between-childhood-trauma-emotion-recognition-and-irritability-in-schizophrenia-patients
#10
Mustafa Melih Bilgi, Seval Taspinar, Burcu Aksoy, Kaya Oguz, Kerry Coburn, Ali Saffet Gonul
This study investigated the relationship between childhood trauma, irritability, and emotion recognition, in schizophrenia patients during a psychotic break. Thirty-six schizophrenia inpatients and 36 healthy controls were assessed with the Irritability Questionnaire (IRQ) and two facial emotion recognition tasks, the Emotion Discrimination Test (EDT) and Emotion Identification Test (EIT). Patients were further assessed with the Structured Clinical Interview for DSM III-R Axis II Disorders (SCID-II), the Positive and Negative Symptom Scale (PANSS), and the Childhood Trauma Questionnaire-28 (CTQ-28)...
February 3, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28192769/disorganization-at-the-stage-of-schizophrenia-clinical-outcome-clinical-biological-study
#11
A Nestsiarovich, V Obyedkov, H Kandratsenka, M Siniauskaya, I Goloenko, N Waszkiewicz
BACKGROUND: According to the multidimensional model of schizophrenia, three basic psychopathological dimensions constitute its clinical structure: positive symptoms, negative symptoms and disorganization. The latter one is the newest and the least studied. Our aim was to discriminate disorganization in schizophrenia clinical picture and to identify its distinctive biological and socio-psychological particularities and associated genetic and environmental factors. METHODS: We used SAPS/SANS psychometrical scales, scales for the assessment of patient's compliance, insight, social functioning, life quality...
December 30, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28190661/the-novel-antipsychotic-drug-brexpiprazole-alone-and-in-combination-with-escitalopram-facilitates-prefrontal-glutamatergic-transmission-via-a-dopamine-d1-receptor-dependent-mechanism
#12
Carl Björkholm, Monica M Marcus, Åsa Konradsson-Geuken, Kent Jardemark, Torgny H Svensson
Brexpiprazole (Rexulti(®)), a novel D2/3 receptor (R) partial agonist, was recently approved as monotherapy for schizophrenia, demonstrating effectiveness against both positive and negative symptoms, and also approved as add-on treatment to antidepressant drugs, inducing a potent antidepressant effect with a faster onset compared to an antidepressant given alone. Moreover, brexpiprazole has demonstrated pro-cognitive effects in preclinical studies. To explore whether the observed effects may be mediated via modulation of prefrontal glutamatergic transmission, we investigated the effect of brexpiprazole, alone and in combination with the SSRI escitalopram, on prefrontal glutamatergic transmission using in vitro electrophysiological intracellular recordings of deep layer pyramidal cells of the rat medial prefrontal cortex (mPFC)...
February 9, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28189096/abnormal-agency-experiences-in-schizophrenia-patients-examining-the-role-of-psychotic-symptoms-and-familial-risk
#13
Merel Prikken, Anouk van der Weiden, Robert A Renes, Martijn G J C Koevoets, Henriette D Heering, René S Kahn, Henk Aarts, Neeltje E M van Haren
Experiencing self-agency over one's own action outcomes is essential for social functioning. Recent research revealed that patients with schizophrenia do not use implicitly available information about their action-outcomes (i.e., prime-based agency inference) to arrive at self-agency experiences. Here, we examined whether this is related to symptoms and/or familial risk to develop the disease. Fifty-four patients, 54 controls, and 19 unaffected (and unrelated) siblings performed an agency inference task, in which experienced agency was measured over action-outcomes that matched or mismatched outcome-primes that were presented before action performance...
November 1, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/28188388/longer-duration-of-untreated-psychosis-hinders-improvement-in-treatment-of-chronic-schizophrenia-community-based-early-intervention-is-an-evidence-based-option
#14
Abdülkadir Tabo, Erkan Aydın, Hüseyin Yumrukçal, Sadık Yiğit, Uğraş Erman Uzun, Oğuz Karamustafalıoğlu
To determine the effects of community-based mental health services on the quality of life and disease symptoms of chronic schizophrenia patients and to determine the effects of duration of untreated psychosis on outcome. The first year records of schizophrenia patients who had been followed up at Zeytinburnu CMHC for at least 12 months, have been used to asses outcome using initial and 12th month quality of life (QoL), positive and negative symptom scale (PANSS) scores. Highly significant improvements were shown in the QoL and PANSS scores...
February 10, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/28187217/electrophysiological-cognitive-and-clinical-profiles-of-at-risk-mental-state-the-longitudinal-minds-in-transition-mint-study
#15
Rebbekah J Atkinson, W Ross Fulham, Patricia T Michie, Philip B Ward, Juanita Todd, Helen Stain, Robyn Langdon, Renate Thienel, Georgie Paulik, Gavin Cooper, Ulrich Schall
The onset of schizophrenia is typically preceded by a prodromal period lasting several years during which sub-threshold symptoms may be identified retrospectively. Clinical interviews are currently used to identify individuals who have an ultra-high risk (UHR) of developing a psychotic illness with a view to provision of interventions that prevent, delay or reduce severity of future mental health issues. The utility of bio-markers as an adjunct in the identification of UHR individuals is not yet established...
2017: PloS One
https://www.readbyqxmd.com/read/28185786/the-course-of-negative-symptoms-in-first-episode-schizophrenia-and-its-predictors-a-prospective-two-year-follow-up-study
#16
Gisela Mezquida, Bibiana Cabrera, Miquel Bioque, Silvia Amoretti, Antonio Lobo, Ana González-Pinto, Ana Espliego, Iluminada Corripio, Eduard Vieta, Josefina Castro-Fornieles, Daniel Bergé, Maria J Escartí, Ángela Ibañez, Rafael Penadés, Ana M Sánchez-Torres, Miguel Bernardo
AIMS: This study aimed to investigate the course of negative symptoms and its stability over a two-year period following a first-episode schizophrenia (FES) and the possible predictors of higher severity in this symptomatology after this period. METHODS: In this longitudinal two-year prospective follow-up study we included 268 patients with a FES, according to DSM-IV. Analysis of variance was conducted in patients who completed the full follow-up to study changes in negative symptoms over three visits...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185784/does-integrated-neurocognitive-therapy-int-reduce-severe-negative-symptoms-in-schizophrenia-outpatients
#17
Daniel R Mueller, Zahra Khalesi, Valentin Benzing, Clelia I Castiglione, Volker Roder
Negative symptoms often inhibit the social integration of people suffering from schizophrenia. Reducing severe negative symptoms (SNS) in a clinically relevant way is a major unmet need. The aim of this study was to investigate whether Integrated Neurocognitive Therapy (INT), a group cognitive remediation therapy (CRT), reduces SNS in schizophrenia outpatients. INT was compared with Treatment As Usual (TAU) in a randomized-controlled trial (RCT). A total of 61 SNS outpatients participated in the study, 28 were allocated to the INT group and 33 to the TAU group...
February 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28185672/cariprazine-versus-risperidone-monotherapy-for-treatment-of-predominant-negative-symptoms-in-patients-with-schizophrenia-a-randomised-double-blind-controlled-trial
#18
György Németh, István Laszlovszky, Pál Czobor, Erzsébet Szalai, Balázs Szatmári, Judit Harsányi, Ágota Barabássy, Marc Debelle, Suresh Durgam, István Bitter, Stephen Marder, W Wolfgang Fleischhacker
BACKGROUND: Although predominant negative symptoms of schizophrenia can be severe enough to cause persistent impairment, effective treatment options are lacking. We aimed to assess the new generation antipsychotic cariprazine in adult patients with predominant negative symptoms. METHODS: In this randomised, double-blind, phase 3b trial, we enrolled adults aged 18-65 years with long-term (>2 year), stable schizophrenia and predominant negative symptoms (>6 months) at 66 study centres (mainly hospitals and university clinics, with a small number of private practices) in 11 European countries...
February 6, 2017: Lancet
https://www.readbyqxmd.com/read/28185671/schizophrenia-primary-negative-symptoms-and-soft-outcomes-in-psychiatry
#19
Stefan Leucht, John M Davis
No abstract text is available yet for this article.
February 6, 2017: Lancet
https://www.readbyqxmd.com/read/28183293/using-video-annotation-software-to-identify-interactions-in-group-therapies-for-schizophrenia-assessing-reliability-and-associations-with-outcomes
#20
Stavros Orfanos, Syeda Ferhana Akther, Muhammad Abdul-Basit, Rosemarie McCabe, Stefan Priebe
BACKGROUND: Research has shown that interactions in group therapies for people with schizophrenia are associated with a reduction in negative symptoms. However, it is unclear which specific interactions in groups are linked with these improvements. The aims of this exploratory study were to i) develop and test the reliability of using video-annotation software to measure interactions in group therapies in schizophrenia and ii) explore the relationship between interactions in group therapies for schizophrenia with clinically relevant changes in negative symptoms...
February 10, 2017: BMC Psychiatry
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