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Schizophrenia and negative symptoms

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https://www.readbyqxmd.com/read/29453145/demographic-and-clinical-characteristics-associated-with-a-history-of-bizarre-delusions-in-a-cross-diagnostic-sample-of-individuals-with-psychotic-disorders
#1
Cagri Yuksel, Seheryeli Yilmaz, Ariana Nesbit, Gresa Carkaxhiu, Caitlin Ravichandran, Paola Salvatore, Samira Pingali, Bruce Cohen, Dost Ongur
Bizarre delusions (BizD) are not specific to schizophrenia (SZ) and can be found in other psychotic disorders. However, to date, there are no studies investigating socio-demographic and clinical characteristics associated with BizD across the psychosis spectrum. In this study 819 subjects with a diagnosis of SZ (n = 250), schizoaffective disorder (SZA) (n = 228) and bipolar I disorder (BD) (n = 341) were included. Patients with history of BizD and with no BizD were compared with respect to socidemographic and clinical variables, and predictors of BizD were explored...
February 9, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29449061/c4a-mrna-expression-in-pbmcs-predicts-the-presence-and-severity-of-delusions-in-schizophrenia-and-bipolar-disorder-with-psychosis
#2
Jennifer K Melbourne, Cherise Rosen, Benjamin Feiner, Rajiv P Sharma
Altered immune function is an established finding in psychotic disorders such as schizophrenia and bipolar disorder with psychosis, though its role in their development and progression remains to be understood. Evidence suggests altered JAK-STAT1 pathway activity in peripheral blood cells from participants with schizophrenia compared to controls. Activation of this pathway leads to increased expression of complement component 4A (C4A), which has recently been implicated in schizophrenia. Here, we examine mRNA expression of C4A in peripheral blood cells from participants with schizophrenia, bipolar disorder and controls...
February 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29449060/the-aprosody-of-schizophrenia-computationally-derived-acoustic-phonetic-underpinnings-of-monotone-speech
#3
Michael T Compton, Anya Lunden, Sean D Cleary, Luca Pauselli, Yazeed Alolayan, Brooke Halpern, Beth Broussard, Anthony Crisafio, Leslie Capulong, Pierfrancesco Maria Balducci, Francesco Bernardini, Michael A Covington
OBJECTIVE: Acoustic phonetic methods are useful in examining some symptoms of schizophrenia; we used such methods to understand the underpinnings of aprosody. We hypothesized that, compared to controls and patients without clinically rated aprosody, patients with aprosody would exhibit reduced variability in: pitch (F0), jaw/mouth opening and tongue height (formant F1), tongue front/back position and/or lip rounding (formant F2), and intensity/loudness. METHODS: Audiorecorded speech was obtained from 98 patients (including 25 with clinically rated aprosody and 29 without) and 102 unaffected controls using five tasks: one describing a drawing, two based on spontaneous speech elicited through a question (Tasks 2 and 3), and two based on reading prose excerpts (Tasks 4 and 5)...
February 12, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29445345/the-impact-of-sex-differences-on-odor-identification-and-facial-affect-recognition-in-patients-with-schizophrenia-spectrum-disorders
#4
Nilufar Mossaheb, Rainer M Kaufmann, Monika Schlögelhofer, Thushara Aninilkumparambil, Claudia Himmelbauer, Anna Gold, Sonja Zehetmayer, Holger Hoffmann, Harald C Traue, Harald Aschauer
Background: Social interactive functions such as facial emotion recognition and smell identification have been shown to differ between women and men. However, little is known about how these differences are mirrored in patients with schizophrenia and how these abilities interact with each other and with other clinical variables in patients vs. healthy controls. Methods: Standardized instruments were used to assess facial emotion recognition [Facially Expressed Emotion Labelling (FEEL)] and smell identification [University of Pennsylvania Smell Identification Test (UPSIT)] in 51 patients with schizophrenia spectrum disorders and 79 healthy controls; furthermore, working memory functions and clinical variables were assessed...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29444726/resting-state-thalamic-dysconnectivity-in-schizophrenia-and-relationships-with-symptoms
#5
J Ferri, J M Ford, B J Roach, J A Turner, T G van Erp, J Voyvodic, A Preda, A Belger, J Bustillo, D O'Leary, B A Mueller, K O Lim, S C McEwen, V D Calhoun, M Diaz, G Glover, D Greve, C G Wible, J G Vaidya, S G Potkin, D H Mathalon
BACKGROUND: Schizophrenia (SZ) is a severe neuropsychiatric disorder associated with disrupted connectivity within the thalamic-cortico-cerebellar network. Resting-state functional connectivity studies have reported thalamic hypoconnectivity with the cerebellum and prefrontal cortex as well as thalamic hyperconnectivity with sensory cortical regions in SZ patients compared with healthy comparison participants (HCs). However, fundamental questions remain regarding the clinical significance of these connectivity abnormalities...
February 15, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29444522/psychotic-symptoms-and-attitudes-toward-medication-mediate-the-effect-of-insight-on-personal-social-functions-in-patients-with-schizophrenia-one-year-randomized-controlled-trial-and-follow-up
#6
Yingjun Zheng, Yuping Ning, Shenglin She, Yongjie Deng, Yuwei Chen, Wenying Yi, Xiaodan Lu, Xinrui Chen, Juanhua Li, Ruikeng Li, Jie Zhang, Di Xiao, Haibo Wu, Chao Wu
AIMS: This study aimed to investigate the mediating pathway of 3 factors (psychotic symptoms, attitude toward medication, and cognitive processing speed) on the effect of insight on personal-social functioning in patients with schizophrenia. METHODS: Chinese inpatients with schizophrenia (n = 168; mean age 18 ± 50 years) diagnosed according to the DSM-IV were randomly assigned to treatment with antipsychotic medication alone or combined treatment. Positive and Negative Syndrome Scale (PANSS), Drug Attitude Inventory (DAI), Assessment of Insight (SAI), and Social-Personal Performance Scale (PSPS) scores were evaluated at baseline and at 3, 6, and 12 months...
February 14, 2018: Psychopathology
https://www.readbyqxmd.com/read/29440953/are-negative-symptoms-in-schizophrenia-a-distinct-therapeutic-target
#7
Octavia Oana Capatina, Ioana Valentina Miclutia
Background and aims: The relationship between negative symptoms and cognition in schizophrenia is not clear, inconsistent findings have been reported by multiple authors and meta analyses. The aim of this study was to investigate the relationship between cognition and primary negative symptoms. Methods: 67 outpatients diagnosed with schizophrenia were evaluated using PANSS and the NSA-16 scale. Correlation and regression analyses were used in the present study to investigate the relationship between the primary negative symptoms and cognition...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29439776/clinical-risk-factors-for-the-development-of-tardive-dyskinesia
#8
REVIEW
Marco Solmi, Giorgio Pigato, John M Kane, Christoph U Correll
BACKGROUND: Tardive dyskinesia (TD) is a severe condition that can affect almost 1 out of 4 patients on current or previous antipsychotic treatment, including both first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs). While two novel vesicular monoamine transporter inhibitors, deutetrabenazine and valbenazine, have shown acute efficacy for TD, the majority of patients do not remit, and TD appears to recur once treatment is withdrawn. Hence, prevention of TD remains a crucial goal...
February 5, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29439750/differential-neural-reward-mechanisms-in-treatment-responsive-and-treatment-resistant-schizophrenia
#9
Lucy D Vanes, Elias Mouchlianitis, Tracy Collier, Bruno B Averbeck, Sukhi S Shergill
BACKGROUND: The significant proportion of schizophrenia patients refractory to treatment, primarily directed at the dopamine system, suggests that multiple mechanisms may underlie psychotic symptoms. Reinforcement learning tasks have been employed in schizophrenia to assess dopaminergic functioning and reward processing, but these have not directly compared groups of treatment-refractory and non-refractory patients. METHODS: In the current functional magnetic resonance imaging study, 21 patients with treatment-resistant schizophrenia (TRS), 21 patients with non-treatment-resistant schizophrenia (NTR), and 24 healthy controls (HC) performed a probabilistic reinforcement learning task, utilizing emotionally valenced face stimuli which elicit a social bias toward happy faces...
February 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29437023/serum-dhea-s-testosterone-and-cortisol-levels-in-female-patients-with-schizophrenia
#10
Suheyla Dogan Bulut, Serdar Bulut, Ayse G Gundogmus, Cigdem Aydemir
OBJECTIVE: Recent studies have shown that sex hormones play a role in the development of schizophrenia and the severity of disease symptoms. However, study results have been inconsistent. This study compares the relationship between the severity of disease symptoms and levels of testosterone, and DHEA-S and cortisol in premenopausal female patients with schizophrenia and a matched group of healthy controls. METHODS: The study sample included 32 women who were diagnosed as having schizophrenia according to DSM-IV TR criteria, and 32 age- and sex-matched healthy controls...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29436320/long-term-outcomes-of-trauma-focused-treatment-in-psychosis
#11
David van den Berg, Paul A J M de Bont, Berber M van der Vleugel, Carlijn de Roos, Ad de Jongh, Agnes van Minnen, Mark van der Gaag
We present 12-month follow-up results for a randomised controlled trial of prolonged exposure and eye movement desensitisation and reprocessing (EMDR) therapy in 85 (78.8%) participants with psychotic disorder and comorbid post-traumatic stress disorder (PTSD). Positive effects on clinician-rated PTSD, self-rated PTSD, depression, paranoid-referential thinking and remission from schizophrenia were maintained up to 12-month follow-up. Negative post-traumatic cognitions declined in prolonged exposure and were stable in EMDR...
February 7, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432331/evaluation-of-the-effect-of-fluvoxamine-in-patients-with-schizophrenia-under-risperidone-treatment-a-clinical-trial
#12
Alireza Haji Seyed Javadi, Ali Akbar Shafikhani, Seyed Mohsen Zamir, Zahra Farzane Khanshir
PURPOSE/BACKGROUND: The effectiveness of selective-serotonin reuptake inhibitors in the improvement of schizophrenia is a controversial issue. The aim of this study was to evaluate the effect of fluvoxamine on the symptoms of schizophrenia including positive and negative symptoms, cognitive impairment, and quality of life. METHODS/PROCEDURES: This clinical trial was performed on 68 patients with chronic schizophrenia, treated with risperidone at 22 Bahman Hospital of Qazvin, Iran during 2015 to 2016...
February 9, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29431197/efficacy-and-safety-of-antidepressant-augmentation-of-continued-antipsychotic-treatment-in-patients-with-schizophrenia
#13
B Galling, J A Vernon, A K Pagsberg, A Wadhwa, E Grudnikoff, A J Seidman, M Tsoy-Podosenin, M Poyurovsky, J M Kane, C U Correll
OBJECTIVE: To evaluate the efficacy and safety of antidepressant augmentation of antipsychotics in schizophrenia. METHODS: Systematic literature search (PubMed/MEDLINE/PsycINFO/Cochrane Library) from database inception until 10/10/2017 for randomized, double-blind, efficacy-focused trials comparing adjunctive antidepressants vs. placebo in schizophrenia. RESULTS: In a random-effects meta-analysis (studies = 42, n = 1934, duration = 10...
March 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29428116/clinical-and-demographic-variables-associated-coping-and-the-burden-of-caregivers-of-schizophrenia-patients
#14
Belvy Mora-Castañeda, María Márquez-González, Alberto Fernández-Liria, Ricardo de la Espriella, Néstor Torres, Álvaro Arenas Borrero
OBJECTIVE: To analyse of the relationship between burden of illness and coping strategies and the demographic variables of caregivers, and the demographic and clinical variables of people diagnosed with schizophrenia. METHODS: Multicentre correlational cross-sectional study including 70 people diagnosed with schizophrenia, or a schizoaffective disorder, and 70 primary informal caregivers. They were evaluated using Zarit Caregiver Burden Inventory, Family Coping Strategies Questionnaire, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, and the brief Disability Assessment Scale...
January 2018: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/29427955/allostatic-load-is-associated-with-psychotic-symptoms-and-decreases-with-antipsychotic-treatment-in-patients-with-schizophrenia-and-first-episode-psychosis
#15
Maximus Berger, Robert-Paul Juster, Sabine Westphal, G Paul Amminger, Bernhard Bogerts, Kolja Schiltz, Sabine Bahn, Johann Steiner, Zoltan Sarnyai
Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics...
February 5, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29427913/l-carnosine-as-an-add-on-to-risperidone-for-treatment-of-negative-symptoms-in-patients-with-stable-schizophrenia-a-double-blind-randomized-placebo-controlled-trial
#16
Alireza Ghajar, Mohammad-Reza Khoaie-Ardakani, Zahara Shahmoradi, Amir-Reza Alavi, Mohsen Afarideh, Mohammad-Reza Shalbafan, Maryam Ghazizadeh-Hashemi, Shahin Akhondzadeh
Since l-carnosine has shown effectiveness in improvement of cognition in patients with schizophrenia, this 8-week, randomized, double-blind, placebo-controlled pilot study was conducted. Sixty-three patients with chronic schizophrenia, who were clinically stable on a stable dose of risperidone, entered the study. The patients were randomly assigned to l-carnosine (2 gr/day in two divided doses) or placebo for eight weeks. The patients were assessed using the positive and negative syndrome scale (PANSS), extrapyramidal symptom rating scale (ESRS), and Hamilton depression rating scale (HDRS) during the study course...
February 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29427912/adjunctive-therapy-with-statins-in-schizophrenia-patients-a-meta-analysis-and-implications
#17
Hong Shen, Rui Li, Rong Yan, Xia Zhou, Xia Feng, Mengjie Zhao, Hong Xiao
There are some conflicting results regarding the benefit of adjunctive therapy with statins for severity of negative symptoms in schizophrenia. This study aimed to verify whether statins use for adjunctive therapy was indeed beneficial to improve psychiatric symptoms in schizophrenia. The data were from CENTRAL, PubMed, Embase and MEDLINE. The Boolean search term used for the electronic database search was (statin OR simvastatin OR atorvastatin OR fluvastatin OR lovastatin OR mevastatin OR pitavastatin OR pravastatin OR rosuvastatin OR cerivastatin) and (schizophrenia OR schizoaffective disorder OR psychosis)...
February 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29425796/doxycycline-prevents-and-reverses-schizophrenic-like-behaviors-induced-by-ketamine-in-mice-via-modulation-of-oxidative-nitrergic-and-cholinergic-pathways
#18
Benneth Ben-Azu, Itivere Adrian Omogbiya, Adegbuyi Oladele Aderibigbe, Solomon Umukoro, Abayomi Mayowa Ajayi, Ezekiel O Iwalewa
The involvement of oxidative/nitrosative stress, cholinergic and inflammatory pathways have been reported to contribute to the pathophysiology of schizophrenia, a debilitating neuropsychiatric disorder. Our previous studies have shown that doxycycline (DOX), a notable member of tetracyclines with proven antioxidant and anti-inflammatory properties, attenuated psychotic-like behaviors induced by apomophine and ketamine (KET) in mice. This present study was designed to further evaluate in detail the ability of DOX and its combination with risperidone (RIS) to prevent and reverse KET-induced schizophrenic-like behaviors and the role of oxidative/nitrosative and cholinergic pathways in mice...
February 6, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29422932/is-the-prevalence-of-the-deficit-syndrome-in-schizophrenia-higher-than-estimated-results-of-a-meta-analysis
#19
Álvaro López-Díaz, Ignacio Lara, Guillermo Lahera
The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is considered that 20-25% of schizophrenia cohorts have DS. The aim of this meta-analysis was to determine the current prevalence of DS, including international and most recent studies. Thirteen observational studies met the inclusion criteria, comprising 2092 patients from eight countries. Pooled proportion of the DS subgroup was 32...
January 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29421173/effects-of-chlorpromazine-on-sleep-quality-clinical-and-emotional-measures-among-patients-with-schizophrenia
#20
Qingli Meng, Rongqin Li, Feng Hou, Qiulan Zhang
OBJECTIVES: The present study was aimed to examine the effects of chlorpromazine on sleep quality, clinical and emotional measures in people suffering from schizophrenia. PATIENTS AND METHODS: Twenty-five patients with schizophrenia or schizoaffective disorder were enrolled in this study. Our study included a one-week running-in no-treatment period and two-month experimental period. Patients received chlorpromazine during the experimental period. The baseline and treatment outcome were recorded...
February 2018: Clinical Neurology and Neurosurgery
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