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Schizophrenia and negative symptoms

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https://www.readbyqxmd.com/read/29232014/mutations-of-the-glycine-cleavage-system-genes-possibly-affect-the-negative-symptoms-of-schizophrenia-through-metabolomic-profile-changes
#1
Akane Yoshikawa, Fumichika Nishimura, Aya Inai, Yosuke Eriguchi, Masaki Nishioka, Atsuhiko Takaya, Mamoru Tochigi, Yoshiya Kawamura, Tadashi Umekage, Kayoko Kato, Tsukasa Sasaki, Yoshiaki Ohashi, Kazuya Iwamoto, Kiyoto Kasai, Chihiro Kakiuchi
AIM: Hypofunction of N-methyl-D-aspartate receptors (NMDARs) may contribute to the pathophysiology of schizophrenia (SCZ). Recently, the glycine cleavage system (GCS) was shown to affect NMDAR function in the brain. GCS functional defects cause nonketotic hyperglycinemia (NKH), the atypical phenotype of which presents psychiatric symptoms similar to SCZ. Here, we examined the involvement of GCS in SCZ. METHODS: First, to identify the rare variants and the exonic deletions, we re-sequenced all the coding exons and the splice sites of four GCS genes (GLDC, AMT, GCSH, DLD) in 474 patients with SCZ and 475 controls and performed multiplex ligation-dependent probe amplification (MLPA) analysis in SCZ...
December 12, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29230810/trauma-exposure-interacts-with-the-genetic-risk-of-bipolar-disorder-in-alcohol-misuse-of-us-soldiers
#2
R Polimanti, J Kaufman, H Zhao, H R Kranzler, R J Ursano, R C Kessler, M B Stein, J Gelernter
OBJECTIVE: To investigate whether trauma exposure moderates the genetic correlation between substance use disorders and psychiatric disorders, we tested whether trauma exposure modifies the association of genetic risks for mental disorders with alcohol misuse and nicotine dependence (ND) symptoms. METHODS: High-resolution polygenic risk scores (PRSs) were calculated for 10 732 US Army soldiers (8346 trauma-exposed and 2386 trauma-unexposed) based on genome-wide association studies of bipolar disorder (BD), major depressive disorder, and schizophrenia...
December 11, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29230398/insulin-signaling-deficiency-produces-immobility-in-caenorhabditis-elegans-that-models-diminished-motivation-states-in-man-and-responds-to-antidepressants
#3
Julie Dagenhardt, Angeline Trinh, Halen Sumner, Jeffrey Scott, Eric Aamodt, Donard S Dwyer
Defects in insulin signaling have been reported in schizophrenia and major depressive disorder, which also share certain negative symptoms such as avolition, anhedonia, and apathy. These symptoms reflect diminished motivational states, which have been modeled in rodents as increased immobility in the forced swimming test. We have discovered that loss-of-function mutations in the insulin receptor (daf-2) and syntaxin (unc-64) genes in Caenorhabditis elegans, brief food deprivation, and exposure to DMSO produce immobility and avolition in non-dauer adults...
November 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/29224023/negative-symptoms-and-avoidance-of-social-interaction-a-study-of-non-verbal-behaviour
#4
Elizabeth Worswick, Sara Dimic, Christiane Wildgrube, Stefan Priebe
BACKGROUND: Non-verbal behaviour is fundamental to social interaction. Patients with schizophrenia display an expressivity deficit of non-verbal behaviour, exhibiting behaviour that differs from both healthy subjects and patients with different psychiatric diagnoses. The present study aimed to explore the association between non-verbal behaviour and symptom domains, overcoming methodological shortcomings of previous studies. SAMPLING AND METHODS: Standardised interviews with 63 outpatients diagnosed with schizophrenia were videotaped...
December 9, 2017: Psychopathology
https://www.readbyqxmd.com/read/29217297/defects-in-bioenergetic-coupling-in-schizophrenia
#5
REVIEW
Courtney R Sullivan, Sinead M O'Donovan, Robert E McCullumsmith, Amy Ramsey
Synaptic neurotransmission relies on maintenance of the synapse and meeting the energy demands of neurons. Defects in excitatory and inhibitory synapses have been implicated in schizophrenia, likely contributing to positive and negative symptoms as well as impaired cognition. Recently, accumulating evidence has suggested that bioenergetic systems, important in both synaptic function and cognition, are abnormal in psychiatric illnesses such as schizophrenia. Animal models of synaptic dysfunction demonstrated endophenotypes of schizophrenia as well as bioenergetic abnormalities...
October 24, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29213090/evaluation-of-short-interval-cortical-inhibition-and-intracortical-facilitation-from-the-dorsolateral-prefrontal-cortex-in-patients-with-schizophrenia
#6
Yoshihiro Noda, Mera S Barr, Reza Zomorrodi, Robin F H Cash, Faranak Farzan, Tarek K Rajji, Robert Chen, Zafiris J Daskalakis, Daniel M Blumberger
GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have established a method to index these functions from the DLPFC using the paired transcranial magnetic stimulation (TMS) paradigms of short interval intracortical inhibition (SICI) and facilitation (ICF) combined with electroencephalography (EEG). In this study, we aimed to evaluate neurophysiological indicators related to GABAA and glutamate receptor-mediated functions respectively from the DLPFC in patients with schizophrenia using these paradigms, compared to healthy controls...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209237/decreased-left-putamen-and-thalamus-volume-correlates-with-delusions-in-first-episode-schizophrenia-patients
#7
Xiaojun Huang, Weidan Pu, Xinmin Li, Andrew J Greenshaw, Serdar M Dursun, Zhimin Xue, Haihong Liu, Zhening Liu
Background: Delusional thinking is one of the hallmark symptoms of schizophrenia. However, the underlying neural substrate for delusions in schizophrenia remains unknown. In an attempt to further our understanding of the neural basis of delusions, we explored gray matter deficits and their clinical associations in first-episode schizophrenia patients with and without delusions. Methods: Twenty-four first-episode schizophrenia patients with delusions and 18 without delusions as well as 26 healthy controls (HC) underwent clinical assessment and whole-brain structural imaging which were acquired a 3...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29207980/pilot-randomised-controlled-trial-of-culturally-adapted-cognitive-behavior-therapy-for-psychosis-cacbtp-in-pakistan
#8
Muhammed Omair Husain, Imran B Chaudhry, Nasir Mehmood, Raza Ur Rehman, Ajmal Kazmi, Munir Hamirani, Tayyeba Kiran, Ameer Bukhsh, Paul Bassett, Muhammad Ishrat Husain, Farooq Naeem, Nusrat Husain
BACKGROUND: Evidence for efficacy of cognitive-behavioural therapy (CBT) in treatment of schizophrenia is growing. CBT is effective and cost efficient in treating positive and negative symptoms. To effectively meet the needs of diverse cultural groups, CBT needs to be adapted to the linguistic, cultural and socioeconomic context. We aimed to assess the feasibility, efficacy and acceptability of a culturally adapted CBT for treatment of psychosis (CaCBTp) in a low-income country. METHODS: Rater-blind, randomised, controlled trial of the use of standard duration CBT in patients with psychosis from a low-income country...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29205993/should-patients-with-schizophrenia-receive-antidepressants
#9
Viacheslav Terevnikov, Jan-Henry Stenberg, Grigori Joffe
Antipsychotics play a key role in the pharmacological treatment of schizophrenia, and monotherapy is effective for most patients. Achieving an optimal treatment response is, however, often difficult. Combining an antidepressant drug to the antipsychotic regimen could potentially improve treatment outcomes, although the evidence supporting the use of such combinations is limited and contradictory. Positive evidence has mostly been obtained from the efficacy of antidepressants acting on monoamine receptors on the negative symptoms of schizophrenia...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29202656/clinical-and-cognitive-significance-of-auditory-sensory-processing-deficits-in-schizophrenia
#10
Holly K Hamilton, Terrance J Williams, Joseph Ventura, Leland J Jasperse, Emily M Owens, Gregory A Miller, Kenneth L Subotnik, Keith H Nuechterlein, Cindy M Yee
OBJECTIVE: Although patients with schizophrenia exhibit impaired suppression of the P50 event-related brain potential in response to the second of two identical auditory stimuli during a paired-stimulus paradigm, uncertainty remains over whether this deficit in inhibitory gating of auditory sensory processes has relevance for patients' clinical symptoms or cognitive performance. The authors examined associations between P50 suppression deficits and several core features of schizophrenia to address this gap...
December 5, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29202427/religiosity-and-religious-delusions-in-schizophrenia-an-observational-study-in-a-hindu-population
#11
Anand Mishra, Basudeb Das, Nishant Goyal
BACKGROUND: Religion exerts a significant effect on the lives of many individuals including people with mental illness. As evidences keep accumulating, role of religion in mental illness is gaining importance. OBJECTIVES: The study was designed to study the effects of religiosity on religious delusions, its presentation, acute course and outcome in schizophrenia. METHOD: The study was a naturalistic observational study. Subjects with schizophrenia were grouped into those with religious (RG) and with non-religious delusions (NG)...
November 27, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29197359/cultural-adaptation-and-validity-of-the-malay-version-of-the-brief-psychiatric-rating-scale-bprs-m-among-patients-with-schizophrenia-in-a-psychiatric-clinic
#12
Anne Yee, Boon Seng Ng, Helenna Maria Hisham Hashim, Mahmoud Danaee, Huai Heng Loh
BACKGROUND: This study evaluates the psychometric properties of the Malay version of the Brief Psychiatric Rating Scale (BPRS-M) among patients with schizophrenia in a psychiatric outpatient clinic. METHODS: Ninety-nine schizophrenia outpatients were administered the Malay version of the Brief Psychiatric Rating Scale (BPRS-M), Malay version of Positive and Negative Syndrome Scale (PANSS), Malay version of Calgary Depression Scale for Schizophrenia (CDSS) and Malay version of World Health Organization Quality of Life - Brief Version (WHOQOL-BREF)...
December 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29197203/positive-impact-of-prescribed-physical-activity-on-symptoms-of-schizophrenia-randomized-clinical-trial
#13
Dorde Curcic, Tamara Stojmenovic, Slavica Djukic-Dejanovic, Nenad Dikic, Milica Vesic-Vukasinovic, Nenad Radivojevic, Marija Andjelkovic, Milica Borovcanin, Gorica Djokic
BACKGROUND: The purpose of this study was to examine functional capacity of cardio-respiratory system in patients with schizophrenia, and to evaluate the effects of 12 weeks prescribed physical activity on aerobic capacity and symptoms of schizophrenia. SUBJECTS AND METHODS: Study involved 80 hospitalized patients with any of the subtypes of schizophrenia (42 men, 38 women). They were divided into two groups: exercise and control group, both with 40 patients. Maximal aerobic capacity (VO2 max) as an indicator of cardiovascular fitness has been obtained by cardiopulmonary stress test on a treadmill...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29196183/nmda-receptor-antagonist-rodent-models-for-cognition-in-schizophrenia-and-identification-of-novel-drug-treatments-an-update
#14
REVIEW
Daniela Cadinu, Ben Grayson, Giovanni Podda, Michael K Harte, Nazanin Doostdar, Joanna C Neill
Negative and cognitive deficit symptoms in schizophrenia remain an unmet clinical need. Improved understanding of the neuro- and psychopathology of cognitive dysfunction in the illness is urgently required to enhance the development of new improved therapeutic strategies. Careful validation of animal models that mimic the behaviour and pathology of complex psychiatric disorders is an essential step towards this goal. Non-competitive NMDAR (N-Methyl-d-aspartate receptor) antagonists e.g. phencyclidine (PCP), ketamine and dizocilpine (MK-801) can effectively replicate certain aspects of negative and cognitive deficits associated with schizophrenia in animals...
November 28, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29195805/-symptomatic-remission-and-its-relationship-to-social-functioning-in-tunisian-out-patients-with-schizophrenia
#15
I El Gharbi, M Chhoumi, A Mechri
INTRODUCTION: The concept of symptomatic and functional remission represents an important challenge in the care of the mentally ill, particularly in patients with schizophrenia. Operational criteria for symptomatic remission in schizophrenia have been proposed by Andreasen et al. (2005). Over the last decade, these criteria have been widely validated; however few studies have been conducted outside developed countries. Moreover, the association of symptomatic remission with functional outcome has not yet been established in developing countries including Tunisia, as there may be variability in the social and familial environment...
November 28, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29195803/-validation-of-the-french-version-of-the-self-evaluation-of-negative-symptoms-sns
#16
C Hervochon, V Bourgeois, M Rotharmel, J-B Duboc, B Le Goff, P Quesada, D Campion, S Dollfus, O Guillin
INTRODUCTION: Schizophrenia is a disorder affecting 1% of the population and is associated with severe functional impairment. Negative symptoms are responsible for the majority of this impairment, and many patients with schizophrenia have negative symptoms. However, their evaluation is still a challenge. Thus, standardized assessments are needed to facilitate identification of these symptoms. Many tools have been developed, but most are based on observer ratings. Self-evaluation can provide an additional outcome measure and allow patients to be more engaged in their treatment...
November 28, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29195746/association-between-migrant-worker-experience-limitations-on-insurance-coverage-and-hospitalization-for-schizophrenia-in-hunan-province-china
#17
Yifan Zhu, Xinran Hu, Bo Yang, Guowei Wu, Zheng Wang, Zhimin Xue, Jincheng Shi, Xuan Ouyang, Zhening Liu, Robert Rosenheck
BACKGROUND: While transnational migration has been shown to be a risk factor for schizophrenia, studies have not examined whether massive internal rural-to-urban migration in China in recent years has increased the risk of hospitalization for schizophrenia, or schizophrenia symptom severity among migrants. METHOD: In a sample of patients acutely hospitalized with schizophrenia in Changsha, Hunan Province, China (N=334), the proportion of past migrant workers among patients was compared to the proportion of past migrant workers in the general adult population of Hunan...
November 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29195165/psychometric-evaluation-of-the-temporal-experience-of-pleasure-scale-teps-in-a-german-sample
#18
Joe J Simon, Johannes Zimmermann, Sheila A Cordeiro, Ina Marée, David E Gard, Hans-Christoph Friederich, Matthias Weisbrod, Stefan Kaiser
Anhedonia, or the inability to experience pleasure, is commonly observed in schizophrenia. It has been suggested that patients with schizophrenia are unable to predict future pleasurable events, but show intact experience of in-the-moment pleasure. Therefore, the Temporal Experience of Pleasure Scale (TEPS), a self-report measure allowing the assessment of anticipatory and consummatory pleasure, has been developed. To validate the German version of the TEPS, we recruited 59 healthy control participants and 51 patients with schizophrenia or schizoaffective disorder who completed the TEPS as well as a battery of psychometric tests to assess psychopathology, in particular self-rated anhedonia and clinician-rated apathy as well as overall measures of negative symptoms...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29190530/rare-missense-coding-variants-in-oxytocin-receptor-oxtr-in-schizophrenia-cases-are-associated-with-early-trauma-exposure-cognition-and-emotional-processing
#19
Andre B Veras, Mara Getz, Robert C Froemke, Antonio Egidio Nardi, Gilberto Sousa Alves, Julie Walsh-Messinger, Moses V Chao, Thorsten M Kranz, Dolores Malaspina
BACKGROUND: Oxytocin is a peptide hormone that influences the integration of social cognition with behavior and affect regulation. Oxytocin also prominently directs the transition of neuronal GABA neurotransmission from excitatory to inhibitory after birth. The oxytocin receptor (OXTR) is linked to schizophrenia, a heterogeneous syndrome. Relationships of OXTR polymorphisms with specific clinical features could aid in evaluating any role of oxytocin in the pathogenesis of schizophrenia...
November 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29188780/dizocilpine-induced-psychosis-like-behavior-in-rats-a-possible-animal-model-with-full-spectrum-of-schizophrenia
#20
Sidrah Shahzad, Saara Ahmad, Syeda Madiha, Saima Khaliq, Laraib Liaquat, Sadia Sadir, Sahar Rafiq, Saiqa Tabassum, Zehra Batool, Saida Haider
Schizophrenia (SZ) is categorized as neuropsychiatric disorder with reduced lifespan and significant impairments in social and vocational functioning. One of the best proposed pharmacological animal models is dizocilpine, as it can mimic the full spectrum of schizophrenic disorder including positive and negative symptoms along with cognitive deficits. Dizocilpine is N-methyl-D-aspartate (NMDA) receptor antagonist known to induce hyper-locomotion and stereotyped behavior in rodents. Present study was designed to develop an animal model of SZ via intraperitoneal administration of dizocilpine in rats (100-150g) at a dose of 0...
November 2017: Pakistan Journal of Pharmaceutical Sciences
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