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Schizophrenia and negative symptoms

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https://www.readbyqxmd.com/read/28649941/treatment-effects-of-olanzapine-on-homotopic-connectivity-in-drug-free-schizophrenia-at-rest
#1
Wenbin Guo, Feng Liu, Jindong Chen, Renrong Wu, Lehua Li, Zhikun Zhang, Huafu Chen, Jingping Zhao
OBJECTIVES: Deficits in homotopic connectivity have been implicated in schizophrenia. However, alterations in homotopic connectivity associated with antipsychotic treatments in schizophrenia remain unclear due to lack of longitudinal studies. METHODS: Seventeen drug-free patients with recurrent schizophrenia and twenty-four healthy controls underwent resting-state functional magnetic resonance imaging scans. The patients were scanned at three time points (baseline, 6 weeks of treatment, and 6 months of treatment)...
June 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28647492/eszopiclone-for-persistent-negative-symptoms-in-schizophrenia-an-unintended-n-of-1-study
#2
Urvakhsh Meherwan Mehta, Vinutha Ravishankar, Jagadisha Thirthalli
Persistent negative and cognitive symptoms in patients with schizophrenia pose a significant challenge to clinicians. Being a heterogeneous cluster of symptoms with potentially distinct underlying pathogenesis, it is important to examine novel therapies based on emerging neurobiological evidence. Eszopiclone is known to enhance the deficient sleep spindles that are related to impairments in learning and memory in schizophrenia. In this report we highlight the potential utility of eszopiclone in treating persistent negative symptoms in a patient with chronic schizophrenia...
June 21, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28644707/relationship-between-neurocognitive-function-and-clinical-symptoms-with-self-stigma-in-patients-with-schizophrenia-spectrum-disorders
#3
Sherry Kit Wa Chan, Shiao Yan Sharon Kao, Shing Lam Leung, Christy Lai Ming Hui, Edwin Ho Ming Lee, Wing Chung Chang, Eric Yu Hai Chen
BACKGROUND: Self-stigma is associated with poor outcomes of patients with schizophrenia and development of self-stigma is a complex process. Results of studies on relationship of both positive and negative symptoms of psychosis with self-stigma have been inconsistent. Cognitive deficits are common to patients. However, number of studies exploring the relationship specifically between self-stigma and neurocognition are limited. AIMS: The current study aimed to examine the relationship between neurocognitive functions and clinical symptoms with self-stigma...
June 23, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28638202/characteristics-of-aggressive-behavior-among-male-inpatients-with-schizophrenia
#4
Xiaomin Zhu, Wen Li, Xiaoping Wang
BACKGROUND: The incidence of the aggressive behavior is higher among the patients with severe mental disorder such as schizophrenia than the general population. The study of factors related to aggressive behavior has great meaning in designing prevention and intervention methods with this population of patients. AIMS: To understand the characteristics of assaultive behavior of male patients with schizophrenia who have been hospitalized. METHODS: Using a continuous sampling method, data from 75 male inpatients with a diagnosis of schizophrenia was collected at the psychiatric unit of Central South University Second Xiangya Hospital (Changsha, China) from August 2015 to February 2016...
October 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28638192/treatment-effect-of-antipsychotics-in-combination-with-horticultural-therapy-on-patients-with-schizophrenia-a-randomized-double-blind-placebo-controlled-study
#5
Shunhong Zhu, Hengjing Wan, Zhide Lu, Huiping Wu, Qun Zhang, Xiaoqiong Qian, Chenyu Ye
BACKGROUND: As a newly developed treatment method for schizophrenia, horticultural therapy is gaining more attention. However, there is as of now little research investigating this topic as well as a general lack of studies adopting into standard treatment plans. AIMS: Investigate treatment effect of horticultural therapy on patients with schizophrenia and its possibility of standardized application in psychiatric hospitals. METHODS: 110 patients with schizophrenia who met the inclusion criteria and provided informed consent were selected from the rehabilitation ward of the Minhang District Mental Health Center from September 2015 to December 2015...
August 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28638191/tai-chi-for-schizophrenia-a-systematic-review
#6
Wei Zheng, Qiang Li, Jingxia Lin, Yingqiang Xiang, Tong Guo, Qiong Chen, Dongbin Cai, Yutao Xiang
BACKGROUND: Tai Chi as a form of moderate aerobic exercise originating in China, could promote balance and healing of the mind-body. Furthermore, Tai Chi has been used as an adjunctive treatment for patients with schizophrenia. However, no meta-analysis or systematic review on adjunctive Tai Chi for patients with schizophrenia has yet been reported. AIM: A systematic review and meta-analysis was conducted to examine the efficacy of Tai Chi as an adjunctive treatment for schizophrenia using randomized controlled trial (RCT) data...
August 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28637521/rapid-improvement-in-beliefs-mood-and-performance-following-an-experimental-success-experience-in-an-analogue-test-of-recovery-oriented-cognitive-therapy
#7
P M Grant, D Perivoliotis, L Luther, K Bredemeier, A T Beck
BACKGROUND: Negative symptoms significantly contribute to disability and lack of community participation for low functioning individuals with schizophrenia. Cognitive therapy has been shown to improve negative symptoms and functional outcome in this population. Elucidation of the mechanisms of the therapy would lead to a better understanding of negative symptoms and the development of more effective interventions to promote recovery. The objective of this study was to determine (1) whether guided success at a card-sorting task will produce improvement in defeatist beliefs, positive beliefs about the self, mood, and card-sorting performance, and (2) whether these changes in beliefs and mood predict improvements in unguided card-sorting...
June 22, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28636572/mood-symptoms-in-stabilized-patients-with-schizophrenia-a-bipolar-type-with-predominant-psychotic-features
#8
Konstantinos N Fountoulakis, Dina Popovic, Mariela Mosheva, Melina Siamouli, Katerina Moutou, Xenia Gonda
BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) are traditionally distinguished on the basis of progressive deterioration and long-term outcome, but a more dimensional approach is warranted. There are limited data on the occurrence of manic symptoms in patients with schizophrenia. The aim of the current study was to search for patterns in the clinical symptomatology, which may suggest the presence of one or several mood disorders under the label of schizophrenia. SUBJECTS AND METHODS: Hundred-seventy-five patients diagnosed with schizophrenia according to DSM-5 were included in the study...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28636571/schizophrenia-and-bipolar-affective-disorder-a-dimensional-approach
#9
Demet Sağlam Aykut, Filiz Civil Arslan, Evrim Özkorumak, Ahmet Tiryaki
AIM: Schizophrenia (SCH) and bipolar affective disorder (BAD) are currently classified separately according to the DSM (The Diagnostic and Statistical Manual of Mental Disorders) and ICD (International Statistical Classification of Diseases and Related Health Problems) standardized diagnostic guidelines. However, the validity of this categorical approach is controversial because psychotic symptoms may be observed in both diagnoses. The purpose of this study was to compare the clinical and social characteristics in a sample group consisting of patients diagnosed with SCH or BAD to help demonstrate the basic difficulty in the current classification of SCH and BAD as two etiologically distinct diseases...
June 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28634445/antioxidant-treatment-with-n-acetyl-cysteine-prevents-the-development-of-cognitive-and-social-behavioral-deficits-that-result-from-perinatal-ketamine-treatment
#10
Aarron Phensy, Hasmik E Duzdabanian, Samantha Brewer, Anurag Panjabi, Christopher Driskill, Annuska Berz, George Peng, Sven Kroener
Alterations of the normal redox state can be found in all stages of schizophrenia, suggesting a key role for oxidative stress in the etiology and maintenance of the disease. Pharmacological blockade of N-methyl-D-aspartic acid (NMDA) receptors can disrupt natural antioxidant defense systems and induce schizophrenia-like behaviors in animals and healthy human subjects. Perinatal administration of the NMDA receptor (NMDAR) antagonist ketamine produces persistent behavioral deficits in adult mice which mimic a range of positive, negative, and cognitive symptoms that characterize schizophrenia...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28634108/disturbances-of-novel-object-exploration-and-recognition-in-a-chronic-ketamine-mouse-model-of-schizophrenia
#11
Maria Jelena Hauser, Dirk Isbrandt, Jochen Roeper
Schizophrenia is a chronic and devastating disease with an overall lifetime risk of 1%. While positive symptoms of schizophrenia such as hallucinations and delusions are reduced by antipsychotic medication based on the inhibition of type 2 dopaminergic receptors (D2R), negative symptoms (e.g. reduced motivation) and cognitive symptoms (e.g. impaired working memory) of schizophrenia are not effectively treated by current medication. This dichotomy might arise in part because of our limited understanding of the pathophysiology of negative and cognitive symptoms in schizophrenia...
June 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28633055/face-related-visual-search-deficits-in-first-episode-schizophrenia
#12
Shenglin She, Bei Zhang, Xuanzi Li, Xiaofei Zhang, Ruikeng Li, Juanhua Li, Taiyong Bi, Yingjun Zheng
Schizophrenia is considered a complex illness with multiple cognitive dysfunctions, including a deficit in visual processing. However, whether the deficiency of visual processing in schizophrenia is general across stimuli or stimulus-specific remains the subject of debate. In the current study, eighteen first-episode schizophrenic patients and eighteen healthy controls participated in three visual search tasks in which they were asked to search a specific target of a triangle, face identity or facial affect...
June 15, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28627459/peripheral-blood-gene-expression-of-acute-phase-proteins-in-people-with-first-episode-psychosis
#13
Jie Yin Yee, Milawaty Nurjono, Wai Yee Ng, Stephanie Ruth Teo, Tih-Shih Lee, Jimmy Lee
BACKGROUND: There is a growing interest in the association between schizophrenia and the activation of inflammatory system with signs of acute phase (AP) response. Majority of such studies had focused on C-reactive protein (CRP). The aims of the present study were (i) to examine the gene expression profiles of other acute phase proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), and alpha-2 macroglobulin (A2M) in patients with first episode psychosis (FEP) over a period of three months and (ii) to explore the association between APP levels and severity of symptoms...
June 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28626392/sensing-the-worst-neurophenomenological-perspectives-on-neutral-stimuli-misperception-in-schizophrenia-spectrum
#14
Mariateresa Sestito, Josef Parnas, Carlo Maggini, Vittorio Gallese
While investigating social cognitive impairments in schizophrenia, prominent evidence has been found that patients with schizophrenia show a tendency to misclassify neutral stimuli as negatively valenced. Within this population, patients presenting delusions are more prone to this phenomenon. In a previous study, Schizophrenia spectrum (SzSp) patients rated positive, negative and neutral stimuli that were multimodally presented, while assessed with a checklist exploring anomalous subjective experiences and evaluated for positive and negative symptomatology...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28626273/combined-antipsychotics-and-electroconvulsive-therapy-in-an-acutely-psychotic-patient-with-treatment-resistant-schizophrenia
#15
Ruth Rayikanti, Iga Lentowicz, Badari Birur, Li Li
Treatment of patients with Treatment-resistant Schizophrenia (TRS), who fail to respond to multiple antipsychotic trials, including clozapine (CLZ), is challenging. Several alternative strategies are reported in studies, one of which includes augmenting antipsychotics (AP) with Electroconvulsive therapy (ECT). We discuss a case of an acutely psychotic patient with TRS who responded effectively and sustained remission to this strategy which was ECT combined with two AP, CLZ and aripiprazole. Notable improvement in clinical and cognitive outcomes was seen with just five right unilateral ECT sessions, CLZ titrated up to 62...
May 15, 2017: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/28625216/symptom-rating-scales-for-schizophrenia-and-other-primary-psychotic-disorders-in-icd-11
#16
J W Keeley, W Gaebel
The subtype system for categorising presentations of schizophrenia will be removed from International Classification of Diseases 11th Revision. In its place will be a system for rating six domains of psychotic disorder pathology: positive symptoms, negative symptoms, depressive symptoms, manic symptoms, psychomotor symptoms and cognitive symptoms. This paper outlines the rationale and description of the proposed symptom rating scale, including current controversies. In particular, the scale could adopt either a 4-point severity rating or a 2-point presence/absence rating...
June 19, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28624138/serum-ncam-levels-and-cognitive-deficits-in-first-episode-schizophrenia-patients-versus-health-controls
#17
HuiMei An, LuPing Zhou, Yinghua Yu, Hongzhen Fan, FengMei Fan, Shuping Tan, ZhiRen Wang, Boz Z, Jing Shi, FuDe Yang, Xiangyang Zhang, Yunlong Tan, Xu-Feng Huang
BACKGROUND: Neural cell adhesion molecule (NCAM) is a glycoprotein and plays an important role in cell-cell adhesion, neural migration, neurite outgrowth, synaptic plasticity and brain development. We investigated the relationship between the serum NCAM concentration and cognitive deficit in first episode drug naïve schizophrenia (FES) patients. METHODS: Thirty FES patients and thirty healthy controls were recruited for this study. Psychiatric symptoms were assessed by the positive and negative syndrome scale (PANSS)...
June 15, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28623813/association-between-altered-physical-activity-and-neurocognitive-function-among-people-with-schizophrenia-a-minimum-6-months-follow-up-study
#18
Yusuke Kurebayashi, Junichi Otaki
BACKGROUND: The long-term benefits of physical activity on neurocognitive function among patients with schizophrenia, specifically among inpatients, remain unclear. This preliminary study, with a minimum of 6-months' follow-up, examined alterations in physical activity and neurocognitive function in both inpatients and outpatients with schizophrenia. METHODS: Symptoms and neurocognitive function were assessed at 2 intervals using the Positive and Negative Symptom Scale and Cognitrax, respectively...
June 7, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28623767/an-examination-of-the-roles-of-glutamate-and-sex-in-latent-inhibition-relevance-to-the-glutamate-hypothesis-of-schizophrenia
#19
Andrew Chih Wei Huang, Alan Bo-Han He, Chih-Chung Chen
The present study examined the effects of the glutamate receptor antagonist MK-801, the glutamate receptor agonist N-methyl-D-aspartate (NMDA), and sexual dimorphism on latent inhibition to elucidate the glutamate hypothesis of schizophrenia. During the pre-exposure phase, 56 male and 65 female Wistar rats were intracerebroventricularly administered normal saline, MK-801 or NMDA, in the left ventricle and then exposed to a passive avoidance box (or a different context) in three trials over 3 days. Then, all of the rats were placed in the light compartment of the passive avoidance box and were allowed to enter the dark compartment, where they each received a footshock (1mA, 2s) in five trials over 5 days...
June 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28623450/the-relationship-between-excitement-symptom-severity-and-extrastriatal-dopamine-d2-3-receptor-availability-in-patients-with-schizophrenia-a-high-resolution-pet-study-with-18-f-fallypride
#20
Yo-Han Joo, Jeong-Hee Kim, Young-Don Son, Hang-Keun Kim, Yeon-Jeong Shin, Sang-Yoon Lee, Jong-Hoon Kim
The purpose of this study was to investigate the relationship between specific symptom severity and D2/3 receptor availability in extrastriatal regions in outpatients with schizophrenia to shed light on the role of extrastriatal dopaminergic neurotransmission in the pathophysiology of symptoms of schizophrenia. Sixteen schizophrenia patients receiving relatively low-dose maintenance atypical antipsychotics and seventeen healthy controls underwent 3-Tesla magnetic resonance imaging and high-resolution positron emission tomography with [(18)F]fallypride...
June 16, 2017: European Archives of Psychiatry and Clinical Neuroscience
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