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Schizophrenia and negative symptoms

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https://www.readbyqxmd.com/read/29036720/the-relationship-between-clinical-and-personal-recovery-in-patients-with-schizophrenia-spectrum-disorders-a-systematic-review-and-meta-analysis
#1
Robin Michael Van Eck, Thijs Jan Burger, Astrid Vellinga, Frederike Schirmbeck, Lieuwe de Haan
Patients describe experiencing personal recovery despite ongoing symptoms of psychosis. The aim of the current research was to perform a meta-analysis investigating the relationship between clinical and personal recovery in patients with schizophrenia spectrum disorders. A comprehensive OvidSP database search was performed to identify relevant studies. Correlation coefficients of the relationship between clinical and personal recovery were retrieved from primary studies. Meta-analyses were performed, calculating mean weighted effect sizes for the association between clinical and personal recovery, hope, and empowerment...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036701/mismatch-negativity-but-not-p300-is-associated-with-functional-disability-in-schizophrenia
#2
Holly K Hamilton, Veronica B Perez, Judith M Ford, Brian J Roach, Judith Jaeger, Daniel H Mathalon
Mismatch negativity (MMN) and P300 event-related potential (ERP) reductions in schizophrenia (SZ) reflect preattentive and attention-mediated auditory processing deficits, respectively. Although both have been linked to cognitive deficits in SZ, their relative contributions to real-world functioning are unclear. We sought to determine the functional significance of disrupted auditory processing in SZ by examining MMN and P300 in typically disabled low-functioning patients and in patients with high levels of independent role functioning...
August 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036672/convergence-and-divergence-of-brain-network-dysfunction-in-deficit-and-non-deficit-schizophrenia
#3
Miao Yu, Zhengjia Dai, Xiaowei Tang, Xiang Wang, Xiaobin Zhang, Weiwei Sha, Shuqiao Yao, Ni Shu, Xindi Wang, Jiaying Yang, Xiangyang Zhang, Xiangrong Zhang, Yong He, Zhijun Zhang
Deficit schizophrenia (DS), characterized by primary and enduring negative symptoms, has been considered as a pathophysiologically distinct schizophrenic subgroup. Neuroimaging characteristics of DS, especially functional brain network architecture, remain largely unknown. Resting-state functional magnetic resonance imaging and graph theory approaches were employed to investigate the topological organization of whole-brain functional networks of 114 male participants including 33 DS, 41 non-deficit schizophrenia (NDS) and 40 healthy controls (HCs)...
July 20, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036587/latent-profile-analysis-and-conversion-to-psychosis-characterizing-subgroups-to-enhance-risk-prediction
#4
Kristin M Healey, David L Penn, Diana Perkins, Scott W Woods, Richard S E Keefe, Jean Addington
BACKGROUND: Groups at clinical high risk (CHR) of developing psychosis are heterogeneous, composed of individuals with different clusters of symptoms. It is likely that there exist subgroups, each associated with different symptom constellations and probabilities of conversion. METHOD: Present study used latent profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as measured by multiple instruments, including category instances (CAT)...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036391/improvement-in-negative-symptoms-and-functioning-in-cognitive-behavioral-social-skills-training-for-schizophrenia-mediation-by-defeatist-performance-attitudes-and-asocial-beliefs
#5
Eric Granholm, Jason Holden, Matthew Worley
Psychosocial interventions have significant but modest impact on negative symptoms and functioning in schizophrenia. Identifying mechanisms of change in these interventions can inform treatment targets to strengthen these interventions. A number of studies have found associations between dysfunctional attitudes negative symptoms and functioning in schizophrenia. We previously found improvement in experiential negative symptoms and functioning in cognitive-behavioral social skills training (CBSST) in participants with schizophrenia (N = 149), and the present study examined whether improvements in CBSST in that trial were mediated by the group effect on defeatist performance attitudes and asocial beliefs...
August 3, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036388/risk-factors-for-suicidality-in-patients-with-schizophrenia-a-systematic-review-meta-analysis-and-meta-regression-of-96-studies
#6
Ryan Michael Cassidy, Fang Yang, Flávio Kapczinski, Ives Cavalcante Passos
The lifetime risk of suicide and suicide attempt in patients with schizophrenia are 5% and 25%-50%, respectively. The current meta-analysis aims to determine risk factors associated with suicidality in subjects with schizophrenia. We searched Pubmed, Web of Science, EMBASE, and the reference lists of included studies. Inclusion criteria were met if an article reported a dichotomous sample of patients with schizophrenia with suicidal ideation, attempted suicide, or suicide compared to patients without. We also performed a cohort study meta-analysis as a supplemental analysis...
September 23, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036371/additive-effect-of-cigarette-smoking-on-gray-matter-abnormalities-in-schizophrenia
#7
Naoto Yokoyama, Hitoshi Sasaki, Yasuo Mori, Miki Ono, Kousuke Tsurumi, Ryosaku Kawada, Yukiko Matsumoto, Yujiro Yoshihara, Genichi Sugihara, Jun Miyata, Toshiya Murai, Hidehiko Takahashi
It is widely known that there is a high prevalence of cigarette smoking in schizophrenia. One of the explanations is the self-medication hypothesis. Based on this hypothesis, it has been suggested that nicotine has procognitive effect or even neuroprotective effect in schizophrenia. However, cigarettes contain numerous neurotoxic substances, making the net effect of cigarette smoking on brain function and structure complex. Indeed, recent studies have called into question the self-medication hypothesis. We aimed to test whether there is an interaction between diagnosis and smoking status in gray matter volume, ie, whether smoking has specific effects on gray matter or whether main effects of these 2 variables additively affect common brain regions...
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29035070/verbal-fluency-in-male-and-female-schizophrenia-patients-different-patterns-of-association-with-processing-speed-working-memory-span-and-clinical-symptoms
#8
Gildas Brébion, Christian Stephan-Otto, Susana Ochoa, Lourdes Nieto, Montserrat Contel, Judith Usall
OBJECTIVE: Decreased processing speed in schizophrenia patients has been identified as a major impairment factor in various neuropsychological domains. Working memory span has been found to be involved in several deep or effortful cognitive processes. We investigated the impact that these 2 cognitive functions may have on phonological and semantic fluency in schizophrenia patients and healthy participants. METHOD: Fifty-five patients with schizophrenia and 60 healthy participants were administered a neuropsychological battery including phonological and semantic fluency, working memory, and cognitive and motor speed...
October 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/29033856/possible-facilitative-effects-of-repeated-anodal-transcranial-direct-current-stimulation-on-functional-outcome-1-month-later-in-schizophrenia-an-open-trial
#9
Zui Narita, Takuma Inagawa, Kazuki Sueyoshi, Crystal Lin, Tomiki Sumiyoshi
Recent research on neuromodulation techniques, such as transcranial direct current stimulation (tDCS), for the treatment of schizophrenia has mainly focused on psychotic symptoms. We aimed to determine whether repetitive tDCS is efficacious in improving determinants of outcome, such as cognitive function, daily living skills, and depressive mood in patients with schizophrenia. Twenty-eight patients underwent tDCS (2 mA × 20 min) two times per day for 5 consecutive days. The anodal electrode was placed over the left dorsolateral prefrontal cortex while the cathodal electrode was placed over the right supraorbital region...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29033618/schizophrenia-and-sleep-disorders-links-risks-and-management-challenges
#10
REVIEW
Rachel E Kaskie, Bianca Graziano, Fabio Ferrarelli
Schizophrenia is a major psychiatric disorder that has a massive, long-lasting negative impact on the patients as well as society. While positive symptoms (i.e., delusions and hallucinations), negative symptoms (i.e., anhedonia, social withdrawal), and cognitive impairments are traditionally considered the most prominent features of this disorder, the role of sleep and sleep disturbances has gained increasing prominence in clinical practice. Indeed, the vast majority of patients with schizophrenia report sleep abnormalities, which tend to precede illness onset and can predict an acute exacerbation of psychotic symptoms...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29031122/allocating-effort-and-anticipating-pleasure-in-schizophrenia-relationship-with-real-world-functioning
#11
M Serper, E Payne, C Dill, C Portillo, J Taliercio
BACKGROUND: Poor motivation to engage in goal-oriented behavior has been recognized as a hallmark feature of schizophrenia spectrum disorders (SZ). Low drive in SZ may be related to anticipating rewards as well as to poor working memory. However, few studies to date have examined beliefs about self-efficacy and satisfaction for future rewards (anticipatory pleasure). Additionally, few studies to date have examined how these deficits may impact SZ patients' real world functioning. METHOD: The present study examined SZ patients' (n=57) anticipatory pleasure, working memory, self-efficacy and real world functioning in relation to their negative symptom severity...
August 1, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29030262/combining-actigraphy-ecological-momentary-assessment-and-neuroimaging-to-study-apathy-in-patients-with-schizophrenia
#12
Agne Kluge, Matthias Kirschner, Oliver M Hager, Martin Bischof, Benedikt Habermeyer, Erich Seifritz, Sebastian Walther, Stefan Kaiser
BACKGROUND: Apathy can be defined as a reduction of goal-directed behavior and is a strong predictor for poor functional outcome in schizophrenia. However, no objective measure of apathy has been identified and assessment is limited to retrospective interview-based ratings. Here we aimed to identify more precise objective readouts of apathy for translational research and clinical practice. METHODS: We employed a combined approach including interview-based ratings of the two negative symptom factors apathy and diminished expression, actigraphy based measures of spontaneous motor activity and the evaluation of daily activities using ecological momentary assessment...
October 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29018368/biclustered-independent-component-analysis-for-complex-biomarker-and-subtype-identification-from-structural-magnetic-resonance-images-in-schizophrenia
#13
Cota Navin Gupta, Eduardo Castro, Srinivas Rachkonda, Theo G M van Erp, Steven Potkin, Judith M Ford, Daniel Mathalon, Hyo Jong Lee, Bryon A Mueller, Douglas N Greve, Ole A Andreassen, Ingrid Agartz, Andrew R Mayer, Julia Stephen, Rex E Jung, Juan Bustillo, Vince D Calhoun, Jessica A Turner
Clinical and cognitive symptoms domain-based subtyping in schizophrenia (Sz) has been critiqued due to the lack of neurobiological correlates and heterogeneity in symptom scores. We, therefore, present a novel data-driven framework using biclustered independent component analysis to detect subtypes from the reliable and stable gray matter concentration (GMC) of patients with Sz. The developed methodology consists of the following steps: source-based morphometry (SBM) decomposition, selection and sorting of two component loadings, subtype component reconstruction using group information-guided ICA (GIG-ICA)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29016872/affinity-states-of-striatal-dopamine-d2-receptors-in-antipsychotic-free-patients-with-schizophrenia
#14
Manabu Kubota, Tomohisa Nagashima, Harumasa Takano, Fumitoshi Kodaka, Hironobu Fujiwara, Keisuke Takahata, Sho Moriguchi, Yasuyuki Kimura, Makoto Higuchi, Yoshiro Okubo, Hidehiko Takahashi, Hiroshi Ito, Tetsuya Suhara
Background: Dopamine D2 receptors are reported to have high-affinity (D2High) and low-affinity (D2Low) states. Although an increased proportion of D2High has been demonstrated in animal models of schizophrenia, few clinical studies have investigated this alteration of D2High in schizophrenia in vivo. Methods: Eleven patients with schizophrenia, including 10 antipsychotic-naive and 1 antipsychotic-free individuals, and 17 healthy controls were investigated. Psychopathology was assessed by Positive and Negative Syndrome Scale, and a 5-factor model was used...
July 22, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28990641/dignity-in-older-adults-with-schizophrenia-residing-in-assisted-living-facilities
#15
Darlene Robison, Gloria McInnis-Perry, Lori E Weeks, Vicki Foley
There is a lack of nursing literature on older adults' perceptions of dignity, specifically those of older adults with schizophrenia. With the aging population, mental health services and support for older adults with schizophrenia will become a greater priority. The purpose of the current descriptive phenomenological study was to describe the meaning of the lived experience of dignity for older adults with schizophrenia residing in assisted living facilities. A purposive sample of eight older adults with schizophrenia residing in assisted living facilities participated in semi-structured interviews following the descriptive phenomenological psychological method...
October 6, 2017: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/28981875/predicting-response-to-repetitive-transcranial-magnetic-stimulation-in-patients-with-schizophrenia-using-structural-magnetic-resonance-imaging-a-multisite-machine-learning-analysis
#16
Nikolaos Koutsouleris, Thomas Wobrock, Birgit Guse, Berthold Langguth, Michael Landgrebe, Peter Eichhammer, Elmar Frank, Joachim Cordes, Wolfgang Wölwer, Francesco Musso, Georg Winterer, Wolfgang Gaebel, Göran Hajak, Christian Ohmann, Pablo E Verde, Marcella Rietschel, Raees Ahmed, William G Honer, Dominic Dwyer, Farhad Ghaseminejad, Peter Dechent, Berend Malchow, Peter M Kreuzer, Tim B Poeppl, Thomas Schneider-Axmann, Peter Falkai, Alkomiet Hasan
Background: The variability of responses to plasticity-inducing repetitive transcranial magnetic stimulation (rTMS) challenges its successful application in psychiatric care. No objective means currently exists to individually predict the patients' response to rTMS. Methods: We used machine learning to develop and validate such tools using the pre-treatment structural Magnetic Resonance Images (sMRI) of 92 patients with schizophrenia enrolled in the multisite RESIS trial (http://clinicaltrials...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28981857/transformed-panss-factors-intended-to-reduce-pseudospecificity-among-symptom-domains-and-enhance-understanding-of-symptom-change-in-antipsychotic-treated-patients-with-schizophrenia
#17
Seth C Hopkins, Ajay Ogirala, Antony Loebel, Kenneth S Koblan
Positive and Negative Syndrome Scale (PANSS) total score is the standard primary efficacy measure in acute treatment studies of schizophrenia. However, PANSS factors that have been derived from factor analytic approaches over the past several decades have uncertain clinical and regulatory status as they are, to varying degrees, intercorrelated. As a consequence of cross-factor correlations, the apparent improvement in key clinical domains (eg, negative symptoms, disorganized thinking/behavior) may largely be attributable to improvement in a related clinical domain, such as positive symptoms, a problem often referred to as pseudospecificity...
September 11, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28976410/early-onset-schizophrenia-associated-with-obsessive-compulsive-disorder-clinical-features-and-correlates
#18
Burak Baytunca, Tuğba Kalyoncu, Ismail Ozel, Serpil Erermiş, Bülent Kayahan, Dost Öngur
OBJECTIVES: Obsessive-compulsive disorder (OCD) is notably a comorbid disorder in patients with schizophrenia. This study aimed to evaluate clinical features and correlates of early onset patients with schizophrenia with OCD. METHODS: In the present study, we included 10 patients with both schizophrenia and OCD and 19 patients with schizophrenia without OCD. The mean antipsychotic doses the patients needed for treatment are standardized as chlorpromazine equivalent dose...
October 2, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28974405/structural-anomalies-of-the-peripheral-olfactory-system-in-psychosis-high-risk-subjects
#19
Bruce I Turetsky, Paul J Moberg, Megan Quarmley, Erich Dress, Monica E Calkins, Kosha Ruparel, Karthik Prabhakaran, Raquel E Gur, David R Roalf
BACKGROUND: Olfactory impairments are prominent in both schizophrenia and the preceding at-risk state. Their presence prior to illness predicts poor functional outcome. In schizophrenia, these impairments reflect peripheral olfactory structural abnormalities, which are hypothesized to arise during early embryonic development. If this is correct, then similar structural anomalies should be apparent among clinical high-risk subjects. METHODS: Thirty-nine clinical high-risk (CR) subjects (24M/15F) were compared to 36 low-risk (LR) subjects (19M/17F)...
September 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28971230/effects-of-2-bromoterguride-a-dopamine-d2-receptor-partial-agonist-on-cognitive-dysfunction-and-social-aversion-in-rats
#20
Emilia Tarland, Robert T Franke, Heidrun Fink, Heinz H Pertz, Jan Brosda
RATIONALE: 2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia in rats without inducing extrapyramidal side effects or metabolic changes. OBJECTIVE: In continuation of our recent work, we now investigated the effect of 2-bromoterguride on apomorphine and phencyclidine (PCP)-induced disruptions of prepulse inhibition (PPI) of the acoustic startle response, a measure of sensory gating...
October 3, 2017: Psychopharmacology
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