keyword
MENU ▼
Read by QxMD icon Read
search

Schizophrenia and negative symptoms

keyword
https://www.readbyqxmd.com/read/29691142/oxidative-stress-biomarkers-and-clinical-dimensions-in-first-10-years-of-schizophrenia
#1
Leticia González-Blanco, María Paz García-Portilla, Leticia García-Álvarez, Lorena de la Fuente-Tomás, Celso Iglesias García, Pilar A Sáiz, Susana Rodríguez-González, Ana Coto-Montes, Julio Bobes
INTRODUCTION: Several studies have described increased oxidative stress parameters in patients with schizophrenia. The objectives of the current study were to identify potential oxidative stress biomarkers in stable patients during first 10 years of schizophrenia and determine if they are associated with specific clinical dimensions. MATERIAL AND METHODS: Seventy-three clinically stable outpatients with schizophrenia and 73 sex and age-matched healthy controls were recruited...
April 21, 2018: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29689517/neuropsychological-predictors-of-performance-based-measures-of-functional-capacity-and-social-skills-in-individuals-with-severe-mental-illness
#2
Zanjbeel Mahmood, Cynthia Z Burton, Lea Vella, Elizabeth W Twamley
Neuropsychological abilities may underlie successful performance of everyday functioning and social skills. We aimed to determine the strongest neuropsychological predictors of performance-based functional capacity and social skills performance across the spectrum of severe mental illness (SMI). Unemployed outpatients with SMI (schizophrenia, bipolar disorder, or major depression; n = 151) were administered neuropsychological (expanded MATRICS Consensus Cognitive Battery), functional capacity (UCSD Performance-Based Skills Assessment-Brief; UPSA-B), and social skills (Social Skills Performance Assessment; SSPA) assessments...
April 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29686612/minimal-self-and-timing-disorders-in-schizophrenia-a-case-report
#3
Brice Martin, Nicolas Franck, Michel Cermolacce, Jennifer T Coull, Anne Giersch
For years, phenomenological psychiatry has proposed that distortions of the temporal structure of consciousness contribute to the abnormal experiences described before schizophrenia emerges, and may relate to basic disturbances in consciousness of the self. However, considering that temporality refers mainly to an implicit aspect of our relationship with the world, disturbances in the temporal structure of consciousness remain difficult to access. Nonetheless, previous studies have shown a correlation between self disorders and the automatic ability to expect an event in time, suggesting timing is a key issue for the psychopathology of schizophrenia...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29679793/self-stigma-in-ptsd-prevalence-and-correlates
#4
Kelsey A Bonfils, Paul H Lysaker, Philip T Yanos, Alysia Siegel, Bethany L Leonhardt, Alison V James, Beth Brustuen, Brandi Luedtke, Louanne W Davis
Self-stigma is the internalization of negative societal stereotypes about those with mental illnesses. While self-stigma has been carefully characterized in severe mental disorders, like schizophrenia, the field has yet to examine the prevalence and correlates of self-stigma in post-traumatic stress disorder (PTSD). Thus, we assessed self-stigma in veterans diagnosed with PTSD and compared with veterans with schizophrenia. We further examined associations between PTSD, depressive symptoms and self-stigma in the PTSD sample...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29678772/minocycline-adjunctive-treatment-to-risperidone-for-negative-symptoms-in-schizophrenia-association-with-pro-inflammatory-cytokine-levels
#5
Lulu Zhang, Hongbo Zheng, Rengrong Wu, Furong Zhu, Thomas R Kosten, Xiang-Yang Zhang, Jingping Zhao
BACKGROUND: We attempted to replicate the efficacy of minocycline, a second-generation tetracycline, as adjunctive therapy for the negative symptoms of schizophrenia, and to investigate its association with pro-inflammatory cytokine levels. METHODS: Seventy-five schizophrenia patients with negative symptoms entered a 3-month, double blind, randomized, placebo-controlled clinical trial. Subjects were assigned low dose (100 mg per day) or high dose minocycline (200 mg per day) or placebo combined with risperidone...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29678679/formal-thought-disorders-from-phenomenology-to-neurobiology
#6
REVIEW
Tilo Kircher, Henrike Bröhl, Felicitas Meier, Jennifer Engelen
Formal thought disorder (FTD) is present in most psychiatric disorders and in some healthy individuals. In this Review, we present a comprehensive, integrative, and multilevel account of what is known about FTD, covering genetic, cellular, and neurotransmitter effects, environmental influences, experimental psychology and neuropsychology, brain imaging, phenomenology, linguistics, and treatment. FTD is a dimensional, phenomenologically defined construct, which can be clinically subdivided into positive versus negative and objective versus subjective symptom clusters...
April 17, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29677621/depressive-symptoms-in-chinese-male-inpatients-with-schizophrenia-prevalence-and-clinical-correlates
#7
Yan-Min Xu, Fu Li, Xiao-Bo Liu, Bao-Liang Zhong
Depression is common in patients with schizophrenia and associated with serious consequences. However, previous studies have mixed findings on characteristics of depression in schizophrenia, partly because of the use of depressive symptom scales that are not specific to schizophrenia. This study examined the prevalence and correlates of depressive symptoms in Chinese patients with schizophrenia. A consecutive sample of 349 male inpatients with schizophrenia was recruited from the largest psychiatric specialty hospital in south-central China...
April 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29677618/altered-serum-levels-of-vascular-endothelial-growth-factor-in-first-episode-drug-na%C3%A3-ve-and-chronic-medicated-schizophrenia
#8
Fei Ye, Qiongqiong Zhan, Wenhuan Xiao, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
There is much evidence of a relationship between alterations in the brain's regional cellular energy metabolism and blood flow in schizophrenic. Vascular endothelial growth factor (VEGF) plays a role in the pathogenesis of neuropsychiatric illnesses. So, we compared serum VEGF levels in drug-naïve first-episode psychotic (FEP) and chronically medicated schizophrenic to examine if a correlation existed between VEGF and psychopathological symptoms. The serum VEGF levels were assessed in 46 FEP patients, 47 chronic medicated patients and 50 healthy controls...
April 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29673732/self-assessment-of-social-cognitive-ability-in-schizophrenia-association-with-social-cognitive-test-performance-informant-assessments-of-social-cognitive-ability-and-everyday-outcomes
#9
Juliet M Silberstein, Amy E Pinkham, David L Penn, Philip D Harvey
BACKGROUND: Impairments in self-assessment are common in people with schizophrenia and impairments in self-assessment of cognitive ability have been found to predict impaired functional outcome. In this study, we examined self-assessment of social cognitive ability and related them to assessments of social cognition provided by informants, to performance on tests of social cognition, and to everyday outcomes. The difference between self-reported social cognition and informant ratings was used to predict everyday functioning...
April 17, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29672091/resting-state-connectivity-dynamics-in-individuals-at-risk-for-psychosis
#10
Andrea Pelletier-Baldelli, Jessica R Andrews-Hanna, Vijay A Mittal
Clarifying dynamic fluctuations in resting-state connectivity in individuals at risk for psychosis (termed clinical high risk [CHR]) may inform understanding of psychotic disorders, such as schizophrenia, which have been associated with dysconnectivity and aberrant salience processing. Dynamic functional connectivity (DFC) investigations provide insight into how neural networks exchange information over time. Currently, there are no published DFC studies involving CHR individuals. This is notable, because understanding how networks may come together and disassociate over time could lend insight into the neural communication that underlies psychosis development and symptomatology...
April 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29670128/mitochondrial-function-in-individuals-at-clinical-high-risk-for-psychosis
#11
Tania Da Silva, Abbie Wu, Isabelle Laksono, Ivana Prce, Margaret Maheandiran, Michael Kiang, Ana C Andreazza, Romina Mizrahi
Alterations in mitochondrial function have been implicated in the etiology of schizophrenia. Most studies have investigated alterations in mitochondrial function in patients in which the disorder is already established; however, whether mitochondrial dysfunction predates the onset of psychosis remains unknown. We measured peripheral mitochondrial complex (I-V) function and lactate/pyruvate levels in 27 antipsychotic-naïve individuals at clinical high risk for psychosis (CHR) and 16 healthy controls. We also explored the association between mitochondrial function and brain microglial activation and glutathione levels using a translocator protein 18 kDa [18 F]FEPPA PET scan and 1 H-MRS scan, respectively...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29667181/the-specific-social-costs-of-expressive-negative-symptoms-in-schizophrenia-reduced-smiling-predicts-interactional-outcome
#12
M Riehle, S Mehl, T M Lincoln
OBJECTIVE: We tested whether people with schizophrenia and prominent expressive negative symptoms (ENS) show reduced facial expressions in face-to-face social interactions and whether this expressive reduction explains negative social evaluations of these persons. METHOD: We compared participants with schizophrenia with high ENS (n = 18) with participants with schizophrenia with low ENS (n = 30) and with healthy controls (n = 39). Participants engaged in an affiliative role-play that was coded for the frequency of positive and negative facial expression and rated for social performance skills and willingness for future interactions with the respective role-play partner...
April 17, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29656549/sodium-nitroprusside-is-effective-in-preventing-and-or-reversing-the-development-of-schizophrenia-related-behaviors-in-an-animal-model-the-shr-strain
#13
Mariana C Diana, Fernanda F Peres, Veronica Justi, Rodrigo A Bressan, Acioly L T Lacerda, José Alexandre Crippa, Jaime E C Hallak, Vanesssa Costhek Abilio
AIMS: The treatment of schizophrenia with antipsychotics is still unsatisfactory. Therefore, the search for new treatments and prevention is crucial, and animal models are fundamental tools for this objective. Preclinical and clinical data evidence the antipsychotic profile of sodium nitroprusside (SNP), a nitric oxide (NO) donor. We aimed to investigate SNP in treating and/or preventing the schizophrenia-related behaviors presented by the spontaneously hypertensive rats (SHR) strain...
April 14, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29652309/-dynamics-of-clinical-and-biological-indices-of-the-asthenic-symptom-complex-during-immunotropic-therapy-of-patients-with-schizophrenia
#14
A V Yakimets, S A Zozulya, I V Oleichik, T P Klyushnik
AIM: To identify clinical, psychopathological, and immunological features of the asthenic symptom-complex in patients with schizophrenia and to analyze the possibility of optimizing complex therapy of these conditions using the immunotropic drug bestim. MATERIAL AND METHODS: Forty-three male patients, aged 20-55 years, were examined. Clinical examination of patients (PANSS, MFI-20) was performed before, and 5, 30 days after the end of treatment. The activity of inflammatory markers (leukocyte elastase (LE) and a1-proteinase inhibitor (a1-PI)) was determined in blood serum...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29652308/-clinical-psychopathological-aspects-of-therapeutic-effects-of-agomelatine-valdoxan-and-its-place-in-perfection-of-methods-of-therapy-of-postschizophrenic-depressive-disorders
#15
G P Panteleyeva, L I Abramova, T E Novozhenova, N V Subbotskaya, D V Tikhonov, P E Yumatova, I Yu Nikiforova
AIM: To determine a therapeutic effect of agomelatine (valdoxan) on post-schizophrenic depression (PSD), taking into account its psychopathological structure. MATERIAL AND METHODS: A total of 33 patients of both sexes (average age was 32.1 yrs) with symptoms of post-schizophrenic depression (F20.4 according to ICD-10) were examined by using clinical and psychometric methods in the dynamics of shift-like schizophrenia. HAMD-17, PANSS and CGI-S scales were applied...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29650166/family-experiences-in-communicating-with-family-members-experiencing-social-isolation-after-hospitalization
#16
Mega Lestari Khoirunnisa, Achir Yani Syuhaimie Hamid, Novy Helena Catharina Daulima
OBJECTIVE: Social isolation is one of the negative symptoms of schizophrenia that is likely to persist after hospitalization. This study aimed to describe family experiences in communicating with post-hospitalized family members experiencing social isolation. METHOD: This study used a descriptive phenomenology qualitative approach. The research sample consisted of seven participants selected by a purposive sampling method. Data were obtained through in-depth interviews with family members of people with schizophrenia who experienced social isolation after hospitalization...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29645261/determinants-of-quality-of-life-among-people-diagnosed-with-schizophrenia-at-outpatient-clinics
#17
Abd Alhadi Hasan, Hussein Tumah
PURPOSE: The study examines the determinants of the quality of life (QoL) among outpatients with schizophrenia in Jordan. DESIGN AND METHODS: A cross-sectional study design was used with 157 people with schizophrenia treated in outpatient clinics. Demographic, clinical and psychosocial variables were examined for their influence on QoL. Data were analysed with descriptive statistics, Pearson product moment correlation and stepwise forward multiple linear regression...
April 12, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29628403/spanish-validation-of-the-negative-symptom-assessment-16-nsa-16-in-patients-with-schizophrenia
#18
Leticia Garcia-Alvarez, María Paz Garcia-Portilla, Pilar Alejandra Saiz, Eduardo Fonseca-Pedrero, María Teresa Bobes-Bascaran, Jesús Gomar, José Muñiz, Julio Bobes
INTRODUCTION: Negative symptoms are prevalent in schizophrenia and associated with a poorer outcome. Validated newer psychometric instruments could contribute to better assessment and improved treatment of negative symptoms. The Negative Symptom Assessment-16 (NSA-16) has been shown to have strong psychometric properties, but there is a need for validation in non-English languages. This study aimed to examine the psychometric properties of a Spanish version of the NSA-16 (Sp-NSA-16). MATERIAL AND METHOD: Observational, cross-sectional validation study in a sample of 123 outpatients with schizophrenia...
April 5, 2018: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/29627721/community-based-comprehensive-intervention-for-people-with-schizophrenia-in-guangzhou-china-effects-on-clinical-symptoms-social-functioning-internalized-stigma-and-discrimination
#19
Jie Li, Yuan-Guang Huang, Mao-Sheng Ran, Yu Fan, Wen Chen, Sara Evans-Lacko, Graham Thornicroft
Comprehensive interventions including components of stigma and discrimination reduction in schizophrenia in low- and middle-income countries (LMICs) are lacking. We developed a community-based comprehensive intervention to evaluate its effects on clinical symptoms, social functioning, internalized stigma and discrimination among patients with schizophrenia. A randomized controlled trial including an intervention group (n = 169) and a control group (n = 158) was performed. The intervention group received comprehensive intervention (strategies against stigma and discrimination, psycho-education, social skills training and cognitive behavioral therapy) and the control group received face to face interview...
April 3, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29627683/blunted-vocal-affect-and-expression-is-not-associated-with-schizophrenia-a-computerized-acoustic-analysis-of-speech-under-ambiguous-conditions
#20
Lauren T Meaux, Kyle R Mitchell, Alex S Cohen
INTRODUCTION: Patients with schizophrenia are consistently rated by clinicians as having high levels of blunted vocal affect and alogia. However, objective technologies have often failed to substantiate these abnormalities. It could be the case that negative symptoms are context-dependent. OBJECTIVES: The present study examined speech elicited under conditions demonstrated to exacerbate thought disorder. METHODS: The Rorschach Test was administered to 36 outpatients with schizophrenia and 25 nonpatient controls...
March 27, 2018: Comprehensive Psychiatry
keyword
keyword
31727
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"