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https://www.readbyqxmd.com/read/28629296/atypical-antipsychotic-use-and-outcomes-in-an-urban-maternal-mental-health-service
#1
Susan Hatters Friedman, Charmian Moller-Olsen, Chandni Prakash, Abigail North
Objective Despite many women suffering from psychosis in their childbearing years, limited data exist about the use of atypical antipsychotic agents in pregnancy. Atypical antipsychotic agents are often used to treat bipolar disorder, instead of lithium or valproate because of the known teratogenicity of those agents. As well, atypical antipsychotics are often prescribed in anxiety disorders and depression. This study sought to describe pregnancy outcomes for women prescribed atypical antipsychotics during pregnancy...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28610482/randomised-controlled-trial-of-a-healthy-lifestyle-intervention-among-smokers-with-psychotic-disorders-outcomes-to-36%C3%A2-months
#2
Amanda L Baker, Robyn Richmond, Frances J Kay-Lambkin, Sacha L Filia, David Castle, Jill M Williams, Terry J Lewin, Vanessa Clark, Robin Callister, Kerrin Palazzi
OBJECTIVE: People living with psychotic disorders (schizophrenia spectrum and bipolar disorders) have high rates of cardiovascular disease risk behaviours, including smoking, physical inactivity and poor diet. We report cardiovascular disease risk, smoking cessation and other risk behaviour outcomes over 36 months following recruitment into a two-arm randomised controlled trial among smokers with psychotic disorders. METHODS: Participants ( N = 235) drawn from three sites were randomised to receive nicotine replacement therapy plus (1) a Healthy Lifestyles intervention delivered over approximately 9 months or (2) a largely telephone-delivered intervention (designed to control for nicotine replacement therapy provision, session frequency and other monitoring)...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28590371/cocaine-abuse-traumatic-brain-injury-and-preexisting-brain-lesions-as-risk-factors-for-bupropion-associated-psychosis
#3
Rajdip Barman, Sanjeev Kumar, Bhuvaneshwar Pagadala, Mark B Detweiler
BACKGROUND AND OBJECTIVE: Bupropion is generally considered safe and is widely used both as a monotherapy and as an augmentation agent for the treatment of major depression. Concerns have been raised about bupropion's propensity to precipitate new psychosis and worsen existing psychotic symptoms, although the mechanism is poorly understood. Three cases are reported in which bupropion use was associated with psychosis. The aim of the study was to explore the risk factors and possible mechanisms of psychosis in each case...
June 5, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28586480/lifetime-prevalence-and-correlates-of-schizophrenia-spectrum-affective-and-other-non-affective-psychotic-disorders-in-the-chinese-adult-population
#4
Wing Chung Chang, Corine Sau Man Wong, Eric Yu Hai Chen, Linda Chiu Wa Lam, Wai Chi Chan, Roger Man Kin Ng, Se Fong Hung, Eric Fuk Chi Cheung, Pak Chung Sham, Helen Fung Kum Chiu, Ming Lam, Edwin Ho Ming Lee, Tin Po Chiang, Lap Kei Chan, Gary Kar Wai Lau, Allen Ting Chun Lee, Grace Tak Yu Leung, Joey Shuk Yan Leung, Joseph Tak Fai Lau, Jim van Os, Glyn Lewis, Paul Bebbington
Lifetime prevalence of psychotic disorders varies widely across studies. Epidemiological surveys have rarely examined prevalences of specific psychotic disorders other than schizophrenia, and the majority used a single-phase design without employing clinical reappraisal interview for diagnostic verification. The current study investigated lifetime prevalence, correlates and service utilization of schizophrenia-spectrum, affective, and other non-affective psychotic disorders in a representative sample of community-dwelling Chinese adult population aged 16-75 years (N = 5719) based on a territory-wide, population-based household survey for mental disorders in Hong Kong...
June 6, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28581537/clinical-significance-of-psychotic-like-experiences-in-children-and-adolescents
#5
REVIEW
Barbara Remberk
Psychotic-like experiences (PLEs) are subtle, subclinical hallucinations and delusions which are quite common in general population. In children and youth prevalence rate is probably age-dependent with higher rate in younger population. PLEs are suggested to be a form of extended psychosis phenotype. Similar demographic, genetic and environmental risk factors observed for PLEs and schizophrenia support this hypothesis. Other mental health problems associated with PLEs include depression, suicidality, low functioning and psychiatric comorbidity...
April 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28570803/ketamine-for-depression-2-diagnostic-and-contextual-indications
#6
REVIEW
Chittaranjan Andrade
There is a substantial body of literature comprising anecdotal material and descriptions of uncontrolled and randomized controlled trials addressing the use of subanesthetic doses of ketamine for the off-label treatment of major depressive episodes. This article examines diagnostic indications for the off-label use of ketamine as an antidepressant and possible contexts in which ketamine may be trialled. Ketamine is indicated in patients who are in a major depressive episode. Most of the research data have been collected from patients with major depressive disorder, but patients with bipolar depression have also been studied...
May 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28566948/clinical-and-autoimmune-features-of-a-patient-with-autism-spectrum-disorder-seropositive-for-anti-nmda-receptor-autoantibody
#7
Hélène Gréa, Isabelle Scheid, Alexandru Gaman, Véronique Rogemond, Sandy Gillet, Jérôme Honnorat, Federico Bolognani, Christian Czech, Céline Bouquet, Elie Toledano, Manuel Bouvard, Richard Delorme, Laurent Groc, Marion Leboyer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoantibodies directed against brain targets are involved in ASD remains an open question. Here, we identified within a cohort an ASD patient with multiple circulating autoantibodies, including the well-characterized one against glutamate NMDA receptor (NMDAR-Ab)...
March 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28532510/gender-differences-in-psychiatric-diagnoses-in-older-people-with-intellectual-disability-a-register-study
#8
Anna Axmon, Magnus Sandberg, Gerd Ahlström
BACKGROUND: Gender differences regarding psychiatric ill-health are well known in the general population. However, not much research is done on people with intellectual disability, and especially not among older people with intellectual disability. METHODS: People with intellectual disability aged 55+ years in 2012 in Sweden were identified through a register containing information on those receiving support and service for this type of disability. The cohort comprised 3609 women and 4327 men with mean age 65 and 64 years, respectively...
May 22, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28531646/lifetime-presence-of-psychotic-symptoms-in-bipolar-disorder-is-associated-with-less-favorable-socio-demographic-and-certain-clinical-features
#9
Bernardo Dell'Osso, Giulia Camuri, Laura Cremaschi, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The presence of psychotic symptoms in bipolar disorder (BD) is considered a feature of higher severity of illness and, in particular, of manic episodes in bipolar I disorder (BD I). However, the possibility to apply the "with psychotic features" specifier to major depressive episodes in either bipolar II disorder (BD II) or BD I highlights the need for additional research in this area. METHODS: The present study assessed the lifetime presence of psychotic symptoms and related socio-demographic and clinical features in a large sample of BD patients (N=360), with (BDPs, N=207) and without a lifetime history of psychosis (BDNPs, N=153)...
July 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28517969/prevalence-and-determinants-of-depression-among-patients-under-the-care-of-traditional-health-practitioners-in-a-kenyan-setting-policy-implications
#10
Christine W Musyimi, Victoria N Mutiso, Abednego M Musau, Lydia K Matoke, David M Ndetei
In Kenya, there is paucity of information on depression among traditional health practitioner (THP) patients, particularly in rural areas. The aim of this study was to estimate prevalence and identify determinants of major depressive disorder (MDD) among patients of THP in rural Kenya using the World Health Organization (WHO) Mental Health Gap Action Programme Intervention Guideline (mhGAP-IG). All adult patients seeking care from trained THPs (either traditional healers such as diviners and herbalists or faith healers, who use treatments such as prayers, laying hands on patients, or providing holy water and ash to their patients) over a period of 3 months (September 2014 to November 2014) were screened for depression using mhGAP-IG and their sociodemographic characteristics recorded...
January 1, 2017: Transcultural Psychiatry
https://www.readbyqxmd.com/read/28493605/adverse-effects-of-obesity-on-cognitive-functions-in-individuals-at-ultra-high-risk-for-bipolar-disorder-results-from-the-global-mood-and-brain-science-initiative
#11
Roger S McIntyre, Rodrigo B Mansur, Yena Lee, Letícia Japiassú, Kun Chen, Rui Lu, Weicong Lu, Xiaodong Chen, Ting Li, Guiyun Xu, Kangguang Lin
BACKGROUND: The burden of illness associated with bipolar disorder (BD) warrants early pre-emption/prevention. Prediction models limited to psychiatric phenomenology have insufficient predictive power. Herein, we aimed to evaluate whether the presence of overweight/obesity is associated with greater cognitive decline in individuals at high risk (HR) or ultra high risk (UHR) for BD. METHODS: We conducted a retrospective analysis to investigate the moderational role of body mass index (BMI) on measures of cognitive function...
March 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28485725/sensory-integration-deficits-support-a-dimensional-view-of-psychosis-and-are-not-limited-to-schizophrenia
#12
O Carter, D Bennett, T Nash, S Arnold, L Brown, R Y Cai, Z Allan, A Dluzniak, K McAnally, D Burr, S Sundram
Visual dysfunction is commonplace in schizophrenia and occurs alongside cognitive, psychotic and affective symptoms of the disorder. Psychophysical evidence suggests that this dysfunction results from impairments in the integration of low-level neural signals into complex cortical representations, which may also be associated with symptom formation. Despite the symptoms of schizophrenia occurring in a range of disorders, the integration deficit has not been tested in broader patient populations. Moreover, it remains unclear whether such deficits generalize across other sensory modalities...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28484349/one-year-follow-up-of-patients-with-a-diagnosis-of-first-episode-psychosis
#13
Atena Enderami, Fatemeh Sheikh Monesi, Mehran Zarghami
INTRODUCTION: Early diagnosis of symptoms related to psychotic disorders causes hyper responsiveness, recurrence reduction and quality of life improvement. The aim of this study was one-year follow-up of the clinical course and outcomes of hospitalized patients with first episode psychotic disorders and detection of factors affecting consequences. METHODS: This longitudinal descriptive study was conducted during 2012 to 2013 on hospitalized patients at Zare Hospital in Sari, Iran, with any psychotic symptoms and with diagnosis of first episode psychosis...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28472198/clozapine-counteracts-a-ketamine-induced-depression-of-hippocampal-prefrontal-neuroplasticity-and-alters-signaling-pathway-phosphorylation
#14
Marion Rame, Dorian Caudal, Esther Schenker, Per Svenningsson, Michael Spedding, Thérèse M Jay, Bill P Godsil
Single sub-anesthetic doses of ketamine can exacerbate the symptoms of patients diagnosed with schizophrenia, yet similar ketamine treatments rapidly reduce depressive symptoms in major depression. Acute doses of the atypical antipsychotic drug clozapine have also been shown to counteract ketamine-induced psychotic effects. In the interest of understanding whether these drug effects could be modeled with alterations in neuroplasticity, we examined the impact of acutely-administered ketamine and clozapine on in vivo long-term potentiation (LTP) in the rat's hippocampus-to-prefrontal cortex (H-PFC) pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28463241/serum-kynurenic-acid-is-reduced-in-affective-psychosis
#15
B E Wurfel, W C Drevets, S A Bliss, J R McMillin, H Suzuki, B N Ford, H M Morris, T K Teague, R Dantzer, J B Savitz
A subgroup of individuals with mood and psychotic disorders shows evidence of inflammation that leads to activation of the kynurenine pathway and the increased production of neuroactive kynurenine metabolites. Depression is hypothesized to be causally associated with an imbalance in the kynurenine pathway, with an increased metabolism down the 3-hydroxykynurenine (3HK) branch of the pathway leading to increased levels of the neurotoxic metabolite, quinolinic acid (QA), which is a putative N-methyl-d-aspartate (NMDA) receptor agonist...
May 2, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28461750/agomelatine-in-the-treatment-of-mild-to-moderate-depression-in-patients-with-cardiovascular-disease-results-of-the-national-multicenter-observational-study-pulse
#16
Vladimir E Medvedev
BACKGROUND: PULSE was a large, observational, multicenter study designed to evaluate the efficacy and safety of agomelatine in the treatment of major depression in patients with cardiovascular disease (CVD). METHODS: Patients with mild-to-moderate major depressive episodes, without psychotic symptoms, were treated as outpatients or in cardiac facilities in 46 regions of Russia. The patients received antidepressant monotherapy with agomelatine 25 or 50 mg, once daily, for 12 weeks...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28456026/quality-of-life-in-chinese-patients-with-schizophrenia-treated-in-primary-care
#17
Yan Li, Cai-Lan Hou, Xin-Rong Ma, Bao-Liang Zhong, Yu Zang, Fu-Jun Jia, Yong-Qiang Lin, Kelly Y C Lai, Helen F K Chiu, Gabor S Ungvari, Brian J Hall, Mei-Ying Cai, Chee H Ng, Yu-Tao Xiang
In China, maintenance treatment for clinically stable patients with schizophrenia is usually provided by primary care physicians. This study examined the quality of life (QOL) in patients with schizophrenia treated in primary care and explored the demographic and clinical characteristics associated with QOL. Altogether, 612 patients with schizophrenia treated in 22 randomly selected primary care services in China formed the study sample. QOL, psychotic and depressive symptoms, extra-pyramidal symptoms and insight were assessed using standardized instruments...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28455892/psychotic-symptoms-as-a-complication-of-electroconvulsive-therapy-a-case-report
#18
Anna Antosik-Wójcińska, Magdalena Chojnacka, Łukasz Święcicki
We report a patient who experienced atypical symptoms in the course of electroconvulsive therapy (ECT). During ECT treatment patient experienced psychotic symptoms which should be differentiated with prolonged delirium and nonconvulsive status epilepticus. 46-year-old female was referred to hospital with a diagnosis of major depressive disorder with no psychotic features in the course of recurrent depression. Despite several changes of pharmacological treatment no improvement was achieved, therefore it was decided to initiate ECT...
February 26, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28452902/delirium-associated-with-fluoxetine-discontinuation-a-case-report
#19
Kuang-Yuan Fan, Hsing-Cheng Liu
BACKGROUND: Withdrawal symptoms on selective serotonin reuptake inhibitor (SSRI) discontinuation have raised clinical attention increasingly. However, delirium is rarely reported in the SSRI discontinuation syndrome. CASE: We report a case of delirium developing after fluoxetine discontinuation in a 65-year-old female patient with major depressive disorder. She experienced psychotic depression with limited response to treatment of fluoxetine 40 mg/d and quetiapine 100 mg/d for 3 months...
May 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28449649/a-case-of-recurrent-depressive-disorder-presenting-with-alice-in-wonderland-syndrome-psychopathology-and-pre-and-post-treatment-fdg-pet-findings
#20
Tatsushi Yokoyama, Tsuyoshi Okamura, Miwako Takahashi, Toshimitsu Momose, Shinsuke Kondo
BACKGROUND: Alice in Wonderland syndrome (AIWS) is a rare neuropsychiatric syndrome that typically manifests in distortion of extrapersonal visual image, altered perception of one's body image, and a disturbed sense of the passage of distance and time. Several conditions have been reported to contribute to AIWS, although its biological basis is still unknown. Here, we present the first case demonstrating a clear concurrence of recurrent depressive disorder and AIWS. The clinical manifestations and pre- and post-treatment fluorodeoxyglucose positron-emission tomographic (FDG-PET) images provide insights into the psychopathological and biological basis of AIWS...
April 27, 2017: BMC Psychiatry
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