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psychotic major depression

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https://www.readbyqxmd.com/read/28413935/predictive-validity-of-the-k-sads-pl-2009-version-in-school-aged-and-adolescent-outpatients
#1
Håkan Jarbin, Markus Andersson, Maria Råstam, Tord Ivarsson
BACKGROUND: The schedule for affective disorders and schizophrenia for school-age children (K-SADS) is one of the most commonly used standardized diagnostic interviews in child and adolescent psychiatry. Validity studies are scarce, and limited to concurrent validity with other measures and clinical diagnoses. AIMS: To evaluate the K-SADS interview in an outpatient child and adolescent psychiatry (CAP) setting with a Longitudinal Expert All Data (LEAD) procedure...
May 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28391165/metapristone-suppresses-non-small-cell-lung-cancer-proliferation-and-metastasis-via-modulating-ras-raf-mek-mapk-signaling-pathway
#2
Guirong Zheng, Zhichun Shen, Hongning Chen, Jian Liu, Kai Jiang, Lulu Fan, Lee Jia, Jingwei Shao
BACKGROUND: Metastasis is the key phase of cancer progression that characterizes a more advanced stage and a poorer prognosis. The majority of cancer fatalities occur as a consequence of metastasis. OBJECTIVE: Mifepristone (RU486), a chemical abortifacient, has recently been used in clinical trials for psychotic depression and cancer chemotherapy. As the most predominant biological active metabolite of mifepristone, metapristone is being developed as a novel cancer metastasis chemopreventive agent by us...
April 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28365466/early-clinical-predictors-and-correlates-of-long-term-morbidity-in-bipolar-disorder
#3
G Serra, A Koukopoulos, L De Chiara, A E Koukopoulos, G Sani, L Tondo, P Girardi, D Reginaldi, R J Baldessarini
OBJECTIVES: Identifying factors predictive of long-term morbidity should improve clinical planning limiting disability and mortality associated with bipolar disorder (BD). METHODS: We analyzed factors associated with total, depressive and mania-related long-term morbidity and their ratio D/M, as %-time ill between a first-lifetime major affective episode and last follow-up of 207 BD subjects. Bivariate comparisons were followed by multivariable linear regression modeling...
February 21, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28358808/interventions-to-treat-mental-disorders-during-pregnancy-a-systematic-review-and-multiple-treatment-meta-analysis
#4
Leontien M van Ravesteyn, Mijke P Lambregtse-van den Berg, Witte J G Hoogendijk, Astrid M Kamperman
BACKGROUND: For women suffering from an antepartum mental disorder (AMD), there is lack of evidence-based treatment algorithms due to the complicated risk-benefit analysis for both mother and unborn child. We aimed to provide a comprehensive overview of pharmacological and non-pharmacological interventions to treat AMD and performed a meta-analysis of the estimated treatment effect on the psychiatric symptoms during pregnancy. METHODS: MedLine, PsycINFO and Embase databases were searched by two independent reviewers for clinical trials with a control condition on treatment of women with AMD, i...
2017: PloS One
https://www.readbyqxmd.com/read/28315937/gender-differences-in-subtypes-of-depression-by-first-incidence-and-age-of-onset-a-follow-up-of-the-lundby-population
#5
Mats Bogren, L Brådvik, C Holmstrand, L Nöbbelin, C Mattisson
The Lundby Study is a prospective mental health survey in a community population (N = 3563), in which data were collected in 4 waves of field-work between 1947 and 1997. We investigated gender differences during the follow-up in overall first incidence rates, ages of onset, and incidence by age of onset patterns, in different subtypes of depression. The overall incidence rate in females was higher than males for most subtypes of depression. However, for depression with melancholic and/or psychotic features, the overall first incidence rate did not differ significantly between the genders...
March 18, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28303578/compulsory-community-and-involuntary-outpatient-treatment-for-people-with-severe-mental-disorders
#6
REVIEW
Steve R Kisely, Leslie A Campbell, Richard O'Reilly
BACKGROUND: It is controversial whether compulsory community treatment (CCT) for people with severe mental illness (SMI) reduces health service use, or improves clinical outcome and social functioning. OBJECTIVES: To examine the effectiveness of compulsory community treatment (CCT) for people with severe mental illness (SMI). SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Study-Based Register of Trials (2003, 2008, 2012, 8 November 2013, 3 June 2016)...
March 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28285771/improvement-in-depression-is-associated-with-improvement-in-cognition-in-late-life-psychotic-depression
#7
Lindsay W Victoria, Ellen M Whyte, Meryl A Butters, Barnett S Meyers, George S Alexopoulos, Benoit H Mulsant, Anthony J Rothschild, Samprit Banerjee, Alastair J Flint
OBJECTIVE: To characterize cognitive function at baseline and investigate the relationship between change in cognition, depression, and psychosis after treatment among older adults with major depressive disorder with psychotic features. METHODS: This was a secondary analysis of a double-blind, randomized, controlled treatment trial at inpatient and outpatient settings at four academic health centers on "Young Old" (aged 60-71 years, N = 71) and "Older" (aged 72-86 years, N = 71) participants diagnosed with psychotic depression...
February 9, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28247268/lithium-in-the-episode-and-suicide-prophylaxis-and-in-augmenting-strategies-in-patients-with-unipolar-depression
#8
REVIEW
Mohammed T Abou-Saleh, Bruno Müller-Oerlinghausen, Alec J Coppen
BACKGROUND: Depressive disorders are a leading cause of the global burden of disease and are associated with high recurrent often continuing morbidity and high excess mortality by suicide and cardiovascular disease. Whilst there are established, effective and cost-effective treatments for depression, their long-term management is often neglected: there is continuing controversy over the case of need for long-term treatment including lifelong treatment and safety issues. OBJECTIVE AND METHODS: In this narrative review, we critically examine the evidence for the effectiveness and safety of lithium salts in the long-term management of unipolar depression...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28242499/the-interaction-of-gsk3b-and-fxr1-genotypes-may-influence-the-mania-and-depression-dimensions-in-mood-disorders
#9
Alexandre Bureau, Jean Martin Beaulieu, Thomas Paccalet, Yvon C Chagnon, Michel Maziade
BACKGROUND: Previous evidence in healthy subjects suggested that functional polymorphisms GSK3B rs12630592 and FXR1 rs496250 interact in regulating mood and emotional processing. We attempted to replicate this interaction primarily on manic and depressive dimensions in mood disorder patients, and secondarily on schizophrenia patients, diagnosis itself and age of onset. METHODS: Symptom dimensions were derived from the Comprehensive Assessment of Symptoms and History 82 items rated lifetime in acute episodes and stabilized interepisode intervals in 384 patients from the Schizophrenia and Bipolar Disorder Eastern Quebec Kindred Study...
February 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28157549/severity-of-complicated-versus-uncomplicated-subthreshold-depression-new-evidence-on-the-monotonicity-thesis-from-the-national-comorbidity-survey
#10
Jerome C Wakefield, Mark F Schmitz
BACKGROUND: "Complicated" subthreshold depression (CsD) includes at least one of six pathosuggestive "complicated" symptoms: >6 months duration, marked role impairment, sense of worthlessness, suicidal ideation, psychotic ideation, and psychomotor retardation. "Uncomplicated" subthreshold depression (UsD) has no complicated features. Whereas studies show that complicated (CMDD) versus uncomplicated (UMDD) major depression differ substantially in severity and prognosis, UsD and CsD severity has not been previously compared...
January 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28142098/evaluating-clinicians-representations-of-schizoaffective-disorder
#11
Christopher A Webb, Jared W Keeley
BACKGROUND: Schizoaffective disorder (SAD) has routinely exhibited poor diagnostic accuracy and reliability. In addition to phenomenological problems with the definition of SAD, the way in which clinicians represent the symptoms of the disorder could contribute to its poor diagnostic outcomes. PURPOSE: The present study sought to examine clinicians' representations of SAD compared to schizophrenia (SCZ), bipolar disorder with psychotic features (BiPD-PSY), and major depressive disorder with psychotic features (MDD-PSY)...
April 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28139360/course-of-psychotic-symptoms-depression-and-global-functioning-in-persons-at-clinical-high-risk-of-psychosis-results-of-a-longitudinal-observation-study-over-three-years-focusing-on-both-converters-and-non-converters
#12
Michael P Hengartner, Karsten Heekeren, Diane Dvorsky, Susanne Walitza, Wulf Rössler, Anastasia Theodoridou
The aim of this study was to test the validity of the CHR state by focusing on the course of psychosis spectrum symptoms, depression and global functioning in converters and non-converters. A total of 188 CHR-positive subjects (60.2% men) aged between 13 and 35years (mean=20.5) at study outset were assessed five times (t0-t4) over a total observation period of 36months. Conversion to manifest psychosis was defined according to ICD-10 criteria for schizophrenia (F20) or brief psychotic disorder (F23). Measures of positive and negative symptoms were assessed with the Structured Interview for Prodromal Syndromes (SIPS), depression with the Calgary Depression Scale (CDS), and global functioning with the Global Assessment of Functioning Scale (GAF)...
January 27, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28138119/the-normalization-of-brain-%C3%A2-%C3%A2-f-fluorodeoxy-d-glucose-positron-emission-tomography-hypometabolism-following-electroconvulsive-therapy-in-a-55-year-old-woman-with-treatment-resistant-late-onset-depression-a-case-report
#13
Jeongjae Bak, Sang Mi Lee, Young-Joon Kwon, Se-Hoon Shim, Joong Il Kim
Major depressive disorder, especially in later life, has heterogeneous clinical characteristics and treatment responses. Symptomatically, psychomotor retardation, lack of energy, and apathy tends to be more common in people with late-onset depression (LOD). Despite recent advances in psychopharmacologic treatments, 20% to 30% of patients with mood disorders experience inadequate responses to medication, often resulting in a trial of electroconvulsive therapy (ECT). However, the therapeutic mechanism of ECT is still unclear...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28135888/curcumin-for-neuropsychiatric-disorders-a-review-of-in-vitro-animal-and-human-studies
#14
Adrian L Lopresti
Turmeric has been used in traditional medicine for centuries to treat a range of ailments. Its primary active constituent curcumin, can influence an array of biological activities. Many of these, such as its anti-inflammatory, antioxidant, neuroprotective, and monoaminergic effects are dysregulated in several neuropsychiatric disorders. In this systematic review, in vitro, animal, and human studies investigating the potential of curcumin as a treatment for neuropsychiatric disorders such as major depressive disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), bipolar disorder, psychotic disorders, and autism are reviewed, and directions for future research are proposed...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28135847/common-dimensional-reward-deficits-across-mood-and-psychotic-disorders-a-connectome-wide-association-study
#15
Anup Sharma, Daniel H Wolf, Rastko Ciric, Joseph W Kable, Tyler M Moore, Simon N Vandekar, Natalie Katchmar, Aylin Daldal, Kosha Ruparel, Christos Davatzikos, Mark A Elliott, Monica E Calkins, Russell T Shinohara, Danielle S Bassett, Theodore D Satterthwaite
OBJECTIVE: Anhedonia is central to multiple psychiatric disorders and causes substantial disability. A dimensional conceptualization posits that anhedonia severity is related to a transdiagnostic continuum of reward deficits in specific neural networks. Previous functional connectivity studies related to anhedonia have focused on case-control comparisons in specific disorders, using region-specific seed-based analyses. Here, the authors explore the entire functional connectome in relation to reward responsivity across a population of adults with heterogeneous psychopathology...
January 31, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28115987/prevalence-of-psychiatric-disorders-comorbidity-patterns-and-repeat-offending-among-male-juvenile-detainees-in-south-korea-a-cross-sectional-study
#16
Johanna Inhyang Kim, Bongseog Kim, Bung-Nyun Kim, Soon-Beom Hong, Dong Woo Lee, Ju-Young Chung, Ji Young Choi, Bum-Sung Choi, Young-Rim Oh, Miwon Youn
BACKGROUND: High rates of psychiatric disorders and comorbidities have been reported in juvenile detainees, and both phenomena are thought to contribute to repeat offending. However, research on this topic has been limited in Asian countries, like South Korea. The purpose of this study was to examine the prevalence of psychiatric disorders, comorbidity patterns, and the relationship between psychiatric disorders and repeat offending among a cross-section of youths detained in a male juvenile detention center in South Korea...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28112021/is-there-a-role-for-cannabidiol-in-psychiatry
#17
Julia Machado Khoury, Maila de Castro Lourenço das Neves, Marco Antônio Valente Roque, Daniela Alves de Brito Queiroz, André Augusto Corrêa de Freitas, Ângelo de Fátima, Fabrício Moreira, Frederico Duarte Garcia
OBJECTIVES: Understanding if cannabidiol (CBD) is a useful and safe for the treatment of psychiatric disorders is essential to empower psychiatrists and patients to take good clinical decisions. Our aim was to conduct a systematic review regarding the benefits and adverse events (AEs) of CBD in the treatment of schizophrenia, psychotic disorders, anxiety disorders, depression, bipolar disorder and substance use disorders. METHODS: We conducted a literature search in PubMed, Scielo, and Clinicaltrials...
January 23, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28109668/childhood-trauma-depression-and-negative-symptoms-are-independently-associated-with-impaired-quality-of-life-in-schizophrenia-results-from-the-national-face-sz-cohort
#18
M Andrianarisoa, L Boyer, O Godin, L Brunel, E Bulzacka, B Aouizerate, F Berna, D Capdevielle, J M Dorey, C Dubertret, J Dubreucq, C Faget, F Gabayet, P M Llorca, J Mallet, D Misdrahi, R Rey, R Richieri, C Passerieux, A Schandrin, A M Tronche, M Urbach, P Vidailhet, F Schürhoff, G Fond
OBJECTIVES: Depression and negative symptoms have been associated with impaired Quality of life (QoL) in schizophrenia (SZ). However, childhood trauma may influence both QoL and depression in SZ patients, with consequences for the management of impaired QoL in SZ patients. The aim of the present study was to determine if childhood trauma was associated with impaired QoL in schizophrenia. METHOD: A sample of 544 community-dwelling stabilized SZ patients enrolled in FACE-SZ cohort were utilized in this study (74...
January 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28100210/prevalence-of-psychiatric-morbidity-in-a-community-sample-in-western-kenya
#19
Edith Kwobah, Steve Epstein, Ann Mwangi, Debra Litzelman, Lukoye Atwoli
BACKGROUND: About 25% of the worldwide population suffers from mental, neurological and substance use disorders but unfortunately, up to 75% of affected persons do not have access to the treatment they need. Data on the magnitude of the mental health problem in Kenya is scarce. The objectives of this study were to establish the prevalence and the socio-demographic factors associated with mental and substance use disorders in Kosirai division, Nandi County, Western Kenya. METHODS: This was a cross sectional descriptive study in which participants were selected by simple random sampling...
January 18, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28097648/a-systematic-review-and-meta-analysis-of-prospective-transition-from-major-depression-to-bipolar-disorder
#20
A Ratheesh, C Davey, S Hetrick, M Alvarez-Jimenez, C Voutier, A Bechdolf, P D McGorry, J Scott, M Berk, S M Cotton
OBJECTIVE: Some people with major depressive disorder (MDD) may be at a pre-onset stage for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We aimed to identify rates and characteristics predictive of transition to BD in prospective follow-up studies of people with MDD. METHODS: Using a systematic search strategy, we identified studies with a diagnostic ascertainment of MDD and BD of an adequate standard, and where the minimum length of follow-up was 6 months...
January 18, 2017: Acta Psychiatrica Scandinavica
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