keyword
https://read.qxmd.com/read/38537134/nk-cell-elicited-gasdermin-d-dependent-hepatocyte-pyroptosis-induces-neutrophil-extracellular-traps-that-facilitates-hbv-related-acute-on-chronic-liver-failure
#1
JOURNAL ARTICLE
Qiang Zhao, Dong-Ping Chen, Hua-Di Chen, Ying-Zhe Wang, Wei Shi, Yi-Tong Lu, Yi-Zheng Ren, Yuan-Kai Wu, Yi-Hua Pang, Hong Deng, Xiaoshun He, Dong-Ming Kuang, Zhi-Yong Guo
BACKGROUND AIMS: Hepatitis B virus (HBV) infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537119/constructing-linear-oriented-pre-vascularized-human-spinal-cord-tissues-for-spinal-cord-injury-repair
#2
JOURNAL ARTICLE
Caixia Fan, Hui Cai, Lulu Zhang, Xianming Wu, Junyan Yan, Lifang Jin, Baowei Hu, Jiaxiong He, Yanyan Chen, Yannan Zhao, Jianwu Dai
Repairing spinal cord injury (SCI) is a global medical challenge lacking effective clinical treatment. Developing human-engineered spinal cord tissues that can replenish lost cells and restore a regenerative microenvironment offers promising potential for SCI therapy. However, creating vascularized human spinal cord-like tissues that mimic the diverse cell types and longitudinal parallel structural features of spinal cord tissues remains a significant hurdle. In present study, vascularized spinal cord tissues (VSCT) were engineered using embryonic human spinal cord-derived neural cells and endothelial cells on linear ordered collagen scaffolds (LOCS)...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38537024/evaluation-the-stress-distribution-in-root-canals-by-3d-finite-element-analysis-after-the-materials-used-in-reattaching-the-vertically-root-fractured-fragments
#3
JOURNAL ARTICLE
Senem Yiğit Özer, Salih Danişman, Törem Özer
The aim was to evaluate the effect of stress distribution on vertical, horizontal, and oblique forces on the tooth model after reattaching the fragments of the maxillary incisor with vertical root fracture (VRF) using different materials, by 3D finite element analysis (FEA). Tooth with a root canal, spongious, and cortical bone models were designed. VRF was modeled on a tooth with 4 different re-attachment models: Group 1: dual-cure cement (DC)+fiber reinforced composite (FRC), Group 2: DC+polyethylene fiber, Group 3: DC+glass fiber, and Group 4:DC...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537023/comparative-study-of-physical-chemical-properties-of-bioactive-glass-ionomer-cement
#4
JOURNAL ARTICLE
Nádia Buzignani Pires Ramos, Klissia Romero Felizardo, Sandrine Bittencourt Berger, Ricardo Danil Guiraldo, Murilo Baena Lopes
This study analyzed the physical-chemical properties of bioactive ionomer materials. Cention N bioactive materials were evaluated chemically activated (CN) and light-cured (CN-LC), Equia Forte Fill (EQUI); conventional resin composite Filtek Z350 XT (Z350); resin glass ionomer cement Riva light Cure (RIVA) and flowable resin composite Filtek Bulk Fill Flow (BULK-F) were evaluated. Sixty specimens (n=10) were prepared for sorption (SR), solubility (SL), flexural strength (FS), shrinkage stress (SS), conversion degree (CD), microhardness (MI), and surface roughness (SR) tests...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537021/impact-of-access-cavity-design-on-fracture-resistance-of-endodontically-treated-maxillary-first-premolar-in-vitro
#5
JOURNAL ARTICLE
Anju Daniel, Abdul Rahman Saleh, Anas Al-Jadaa, Waad Kheder
This study was designed to investigate the impact of access cavity designs on fracture resistance of endodontically treated maxillary first premolars. The study sample consisted of 72 intact maxillary first premolars, randomly divided into six groups (n = 12). A standardized proximal cavity preparation was prepared for all samples using standard bur. Groups I: control group with only standard proximal cavity and no endodontic access, group II: Truss access cavity, group III: Separated access to buccal and palatal canals without removal of dentine in between, group IV: Access to buccal and palatal canals with removal of dentine in between, group V: Traditional access cavity, group VI: Mesio-occlusal-distal cavity (MOD)...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537019/color-matching-and-color-recovery-in-large-composite-restorations-using-single-shade-or-universal-composites
#6
JOURNAL ARTICLE
Ellen Dionélia Alencar Rodrigues Rosa, Larissa Fernandes Vieira Da Silva, Paula Fernanda Damasceno Silva, André Luís Faria E Silva
This study assessed the color-matching ability and color recovery of unprepared teeth when using single-shade composites and a universal composite in large restorations. Buccal and palatine surface colors of molars were measured with a spectrophotometer (CIELAB) before preparing round cavities (6 mm in diameter, 2 mm in depth). The cavities were randomly filled with a single-shade composite (Omnichroma, Diamond One, or Vittra APS Unique) or a universal composite (Filtek Universal). Color measurements of the restored cavities were taken, and overall color differences (ΔEab and ΔE00) and differences in the whitening index for dentistry (ΔWID) from baseline were calculated...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38537012/effect-of-composite-radiopacity-and-margin-location-of-the-restoration-on-the-diagnosis-of-secondary-caries
#7
JOURNAL ARTICLE
Farzaneh Mosavat, Elham Ahmadi, Faezeh Aghajani, Saeed Ramezani
This research aimed to evaluate the effect of the radiopacity of a Bulk-Fill composite (X-TraFil, VOCO, Germany) and a Conventional composite (P60, 3M ESPE, USA) and assessment of the margin location in the enamel and dentin on the diagnosis of secondary caries. 76 intact premolars with MOD preparation were divided into two equal groups and filled with the conventional and bulk-fill composite. Four regions were considered to simulate carious lesions (two regions in enamel and two regions in dentin). In each group, half of the regions in the dentin and half in the enamel were randomly selected for secondary caries simulation and filled with a wax-plaster combination while the remaining regions stayed intact...
2024: Brazilian Dental Journal
https://read.qxmd.com/read/38536934/attenuation-of-fibroblast-activation-and-fibrosis-by-adropin-in-systemic-sclerosis
#8
JOURNAL ARTICLE
Minrui Liang, Nicholas Dickel, Andrea-Hermina Györfi, Bilgesu SafakTümerdem, Yi-Nan Li, Aleix Rius Rigau, Chunguang Liang, Xuezhi Hong, Lichong Shen, Alexandru-Emil Matei, Thuong Trinh-Minh, Cuong Tran-Manh, Xiang Zhou, Ariella Zehender, Alexander Kreuter, Hejian Zou, Georg Schett, Meik Kunz, Jörg H W Distler
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis-associated ( ENHO ) gene, is implicated in metabolism and vascular homeostasis, but its role in the pathogenesis of fibrosis remains enigmatic. Here, we used machine learning approaches in combination with functional in vitro and in vivo experiments to characterize adropin as a potential regulator involved in fibroblast activation and tissue fibrosis in systemic sclerosis (SSc)...
March 27, 2024: Science Translational Medicine
https://read.qxmd.com/read/38536903/restoration-of-motor-function-using-magnetoelectric-metamaterials
#9
JOURNAL ARTICLE
Amos Matsiko
Implantable magnetic materials can be used for wireless neural stimulation and restoration of motor function.
March 27, 2024: Science Robotics
https://read.qxmd.com/read/38536872/membrane-contact-sites-regulate-vacuolar-fission-via-sphingolipid-metabolism
#10
JOURNAL ARTICLE
Kazuki Hanaoka, Kensuke Nishikawa, Atsuko Ikeda, Philipp Schlarmann, Saku Sasaki, Sotaro Fujii, Sayumi Yamashita, Aya Nakaji, Kouichi Funato
Membrane contact sites (MCSs) are junctures that perform important roles including coordinating lipid metabolism. Previous studies have indicated that vacuolar fission/fusion processes are coupled with modifications in the membrane lipid composition. However, it has been still unclear whether MCS-mediated lipid metabolism controls the vacuolar morphology. Here, we report that deletion of tricalbins (Tcb1, Tcb2, and Tcb3), tethering proteins at endoplasmic reticulum (ER)-plasma membrane (PM) and ER-Golgi contact sites, alters fusion/fission dynamics and causes vacuolar fragmentation in the yeast Saccharomyces cerevisiae ...
March 27, 2024: ELife
https://read.qxmd.com/read/38536823/does-the-incorporation-of-graphene-oxide-into-pmma-influence-its-antimicrobial-activity
#11
JOURNAL ARTICLE
I Ferreira, B D Sahm, O L Alves, J A M Agnelli, A C Dos Reis
INTRODUCTION: The increase in infectious diseases mediated by oral bacteria has been one of the most potent threats to human health, specifically to the elderly. Researchers seek to incorporate antimicrobial nanomaterials into PMMA to control the colonization of microorganisms and reduce deadly diseases. OBJECTIVE: To conduct a systematic review to answer the question: "Does graphene oxide incorporated into polymethylmethacrylate influence its antimicrobial activity?" METHODS: The electronic search was performed in PubMed, Embase, Web of Science, Scopus, and Google Scholar databases, and articles published until October 2021 were selected...
March 12, 2024: European Journal of Prosthodontics and Restorative Dentistry
https://read.qxmd.com/read/38536738/spectrophotometric-analysis-of-apical-extrusion-of-sodium-hypochlorite-using-different-irrigation-protocols-in-an-ex-vivo-model-of-immature-teeth
#12
JOURNAL ARTICLE
W Viera, L Gonçalves, V A B Dos Santos, B P F A Gomes, C C Ferraz, J F de Almeida, M Marciano, M Frozoni, A de-Jesus-Soares
OBJECTIVE: To evaluate the effect of different agitation methods on apical extrusion of 1.5% sodium hypochlorite (NaOCl) in an ex vivo model of immature teeth. METHODS: Sixty extracted human inferior incisors were prepared to simulate immature teeth and embedded in an artificial root socket made of silicone impression material. The teeth were then divided into four groups: Conventional needle irrigation (CNI) alone, CNI supplemented with Ultrasonic Irrigant Activation (UIA), EasyClean (EC), or XP-endo Finisher (XPF)...
February 21, 2024: European Journal of Prosthodontics and Restorative Dentistry
https://read.qxmd.com/read/38536725/effect-of-particle-size-and-application-pressure-in-air-borne-particle-abrasion-on-the-adhesion-of-polyetheretherketone
#13
JOURNAL ARTICLE
S C Sahin, L Mutlu-Sagesen, I Karaokutan, M Özcan
INTRODUCTION: This study aims to investigate the effect of different particle sizes and pressures on the shear bond strength (SBS) and the roughness (Ra) of polyetheretherketone. MATERIALS AND METHODS: A total of 117 polyetheretherketone specimens were fabricated and divided into a control (CN: no air-particle abrasion) and eight pre-treatment groups (air-abraded with 50- or 110-μm Al2O3 particles at 1(A), 1.5(B), 2(C), and 2.5(D) bar). The adhesive, Visio...
February 21, 2024: European Journal of Prosthodontics and Restorative Dentistry
https://read.qxmd.com/read/38536654/surgical-technique-proximal-extension-of-instrumentation-using-sublaminar-bands-for-salvage-of-postoperative-proximal-junctional-failure-in-pediatric-patients
#14
JOURNAL ARTICLE
Mason A Fawcett, Richard M Schwend
PURPOSE: Proximal junctional failure is a complication that can occur following posterior spine surgery with instrumentation. The ability to surgically revise this complication is important for the spine surgeon, yet there is little literature on the topic, especially for pediatric patients. METHODS: The technique we describe involves proximal extension of the existing instrumentation using paired levels of sublaminar bands that allows for a smooth transition of forces at the junction of instrumented and non-instrumented regions of the spine...
March 27, 2024: Spine Deformity
https://read.qxmd.com/read/38536641/gut-microbiota-dynamics-in-kk-ay-mice-restoration-following-antibiotic-treatment
#15
JOURNAL ARTICLE
Jinni Hong, Tingting Fu, Weizhen Liu, Miao Yu, Yanshan Lin, Cunyun Min, Datao Lin
The primary aim of this study was to investigate the alterations in the microbial community of KK-Ay mice following antibiotic treatment. A comparative analysis of the gut microbiota was conducted between KK-Ay mice treated with antibiotics and those without treatment. The microbial community dynamics in antibiotic-treated KK-Ay mice were meticulously assessed over an eight-week period using 16S rDNA sequencing analysis. Simultaneously, dynamic renal function measurements were performed. The results demonstrated a marked decrease in bacterial DNA abundance following antibiotic intervention, coupled with a substantial reduction in bacterial diversity and a profound alteration in microbial composition...
March 27, 2024: Folia Microbiologica
https://read.qxmd.com/read/38536617/whole-transcriptome-mapping-reveals-the-lncrna-regulatory-network-of-tfp5-treatment-in-diabetic-nephropathy
#16
JOURNAL ARTICLE
Hongyan Luo, Lirong Yang, Guoqing Zhang, Xi Bao, Danna Ma, Bo Li, Li Cao, Shilu Cao, Shunyao Liu, Li Bao, Jing E, Yali Zheng
BACKGROUND: TFP5 is a Cdk5 inhibitor peptide, which could restore insulin production. However, the role of TFP5 in diabetic nephropathy (DN) is still unclear. OBJECTIVE: This study aims to characterize the transcriptome profiles of mRNA and lncRNA in TFP5-treated DN mice to mine key lncRNAs associated with TFP5 efficacy. METHODS: We evaluated the role of TFP5 in DN pathology and performed RNA sequencing in C57BL/6J control mice, C57BL/6J db/db model mice, and TFP5 treatment C57BL/6J db/db model mice...
March 27, 2024: Genes & Genomics
https://read.qxmd.com/read/38536610/continuous-detection-of-cobalt-ions-and-pyrophosphates-by-nac-cdte-quantum-dots-fluorescence-probes
#17
JOURNAL ARTICLE
Wanqiu Chen, Ting Chen, Min Fang, Weiju Zhu, Cun Li
In this work, a simple and sensitive N-acetyl-L-cysteine (NAC)-covered CdTe quantum dots (NAC-CdTe QDs) fluorescence probe for continuous detection of Co2+ and pyrophosphate ions (PPi, P2 O7 4- ) was synthesized. The fluorescence of the quantum dots was significantly quenched by Co2+ through the coordination of Co2+ and the carboxyl groups on the NAC-CdTe quantum dots. Interestingly, the combination of NAC-CdTe quantum dots with Co2+ yields a new fluorescence probe of Co2+ -modified NAC-CdTe QDs (Co2+ @NAC-CdTe)...
March 27, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38536591/circ_0020460-drives-tumorigenesis-in-cervical-cancer-through-mir-485-3p-sponging
#18
JOURNAL ARTICLE
Kun Yan, Chunyan Hu, Yali Cheng, Lingzhi Zheng, Baojin Zeng, Sujun Zhao, Chen Liu
Deregulation of circular RNAs (circRNAs) is widely recognized in cancer progression. Our study aims to investigate the role of circ_0020460 in the development of cervical cancer (CC) and its potential mechanism of action. Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays were used to detect the expression levels of circ_0020460, miR-485-3p and C-X-C motif chemokine ligand 1 (CXCL1). The roles of circ_0020460 on cell proliferation, cell migration, cell invasion, cell apoptosis, and angiogenesis were investigated using cell counting kit-8 (CCK-8) and Ethynyl deoxyuridine (Edu) assay, wound healing assay, transwell assay, flow cytometry assay, and tube formation assay, respectively...
March 27, 2024: Discover. Oncology
https://read.qxmd.com/read/38536445/after-wounding-a-g-protein-coupled-receptor-promotes-the-restoration-of-tension-in-epithelial-cells
#19
JOURNAL ARTICLE
Ivy Han, Junmin Hua, James S White, James T O'Connor, Lila S Nassar, Kaden J Tro, Andrea Page-McCaw, M Shane Hutson
The maintenance of epithelial barrier function involves cellular tension, with cells pulling on their neighbors to maintain epithelial integrity. Wounding interrupts cellular tension, which may serve as an early signal to initiate epithelial repair. To characterize how wounds alter cellular tension, we used a laser-recoil assay to map cortical tension around wounds in the epithelial monolayer of the Drosophila pupal notum.  Within a minute of wounding, there was widespread loss of cortical tension along both radial and tangential directions...
March 27, 2024: Molecular Biology of the Cell
https://read.qxmd.com/read/38536444/sec18-binds-the-tethering-sm-complex-hops-to-engage-the-qc-snare-for-membrane-fusion
#20
JOURNAL ARTICLE
Amy Orr, William Wickner
Membrane fusion is regulated by Rab GTPases, their tethering effectors such as HOPS, SNARE proteins on each fusion partner, SM proteins to catalyze SNARE assembly, Sec17 (SNAP), and Sec18 (NSF). Though concentrated HOPS can support fusion without Sec18, we now report that fusion falls off sharply at lower HOPS levels, where direct Sec18 binding to HOPS restores fusion. This Sec18-dependent fusion needs adenine nucleotide but neither ATP hydrolysis nor Sec17. Sec18 enhances HOPS recognition of the Qc-SNARE. With high levels of HOPS, Qc has a Km for fusion of a few nM...
March 27, 2024: Molecular Biology of the Cell
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