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Weijun Zhang, Rongna Song, Bingdi Cao, Xiaofang Yang, Dongsheng Wang, Xingmin Fu, Yao Song
The work evaluated the algae cells removal efficiency using titanium salt coagulants with different degree of polymerization (PTCs), and the algae cells aggregates and extracellular organic matter (EOM) under chemical flocculation were investigated. The results indicated that PTCs performed well in algae cells flocculation and separation. The main mechanism using PTCs of low alkalisation degree for algae flocculation was associated with charge neutralization, while adsorption bridging and sweep flocculation was mainly responsible for algae removal by PTCs of high alkalisation degree treatment...
February 10, 2018: Bioresource Technology
P Comizzoli, E E Paulson, L K McGinnis
Studying the reproductive biology of wild animal species produces knowledge beneficial to their management and conservation. However, wild species also share intriguing similarities in reproductive biology with humans, thereby offering alternative models for better understanding the etiology of infertility and developing innovative treatments. The purpose of this review is to raise awareness in different scientific communities about intriguing connections between wild animals and humans regarding infertility syndromes or improvement of fertility preservation...
February 22, 2018: Journal of Assisted Reproduction and Genetics
Fei Liu, Furkan Türker Saricaoglu, Roberto J Avena-Bustillos, David F Bridges, Gary R Takeoka, Vivian C H Wu, Bor-Sen Chiou, Delilah F Wood, Tara H McHugh, Fang Zhong
Cinnamaldehyde, a natural preservative that can non-specifically deactivate foodborne pathogens, was successfully incorporated into fish skin gelatin (FSG) solutions and blow spun into uniform nanofibers. The effects of cinnamaldehyde ratios (5-30%, w / w FSG) on physicochemical properties of fiber-forming emulsions (FFEs) and their nanofibers were investigated. Higher ratios resulted in higher values in particle size and viscosity of FFEs, as well as higher values in diameter of nanofibers. Loss of cinnamaldehyde was observed during solution blow spinning (SBS) process and cinnamaldehyde was mainly located on the surface of resultant nanofibers...
February 22, 2018: International Journal of Molecular Sciences
Samira Fathizadeh, Sohrab Behnia, Javid Ziaei
Molecule-based transistors have attracted most attention due to their exclusive properties. Creating of a molecular transistor as well as engineering its structure have become one of the greatest aims of scientists. We have focused on the environmental dependent behavior of a DNA-templated transistor. Using the statistical distribution of the energy levels, we were able to distinguish the delocalized states of charge carriers and the transition between the localized and delocalized behaviors. On the other hand, we can determine the stability conditions of our quantum dynamical system...
February 22, 2018: Journal of Physical Chemistry. B
Hauke C Schmidt, Christopher B Larsen, Oliver S Wenger
The distance dependence of electron transfer (ET) is commonly investigated in linear rigid rod-like compounds, but studies of molecular wires with integrated corners imposing 90° angles are very rare. By using spirobifluorene as a key bridging element and by substituting it at different positions, two isomeric series of donor-bridge-acceptor compounds with either nearly linear or angled geometries were obtained. Photoinduced ET in both series is dominated by rapid through-bond hole hopping across oligo-fluorenes over distances of up to 70 Å...
February 22, 2018: Angewandte Chemie
Paolo Coghi, Ivan A Yaremenko, Parichat Prommana, Peter S Radulov, Mikhail A Syroeshkin, Yu Jun Wu, Jia Ying Gao, Flora M Gordillo-Martinez, Simon Mok, Vincent K W Wong, Chairat Uthaipibull, Alexander O Terent'ev
Twenty six peroxides belonging to bridged 1,2,4,5-tetraoxanes, bridged 1,2,4-trioxolanes (ozonides), and tricyclic monoperoxides were evaluated for the in vitro antimalarial activity against Plasmodium falciparum (3D7) and for their cytotoxic activities against immortalized human normal fibroblast (CCD19Lu), liver (LO2) and lung (BEAS-2B) cell lines as well as human liver (HepG2) and lung (A549) cancer cell lines. Synthetic ozonides were shown to have highest cytotoxicity on HepG2 (IC50 0.19-0.59 µM) and some of these compounds selectively targeted liver cancer (SI for compounds 13a and 14a is 20 and 28 respectively), which in some cases were higher than that of paclitaxel, artemisinin, artesunic acid...
February 22, 2018: ChemMedChem
André Soares Santos, Augusto Afonso Guerra-Junior, Brian Godman, Alec Morton, Cristina Mariano Ruas
INTRODUCTION: Cost-effectiveness thresholds (CETs) are used to judge if an intervention represents sufficient value for money to merit adoption in healthcare systems. The study was motivated by the Brazilian context of HTA, where meetings are being conducted to decide on the definition of a threshold. AREAS COVERED: An electronic search was conducted on Medline (via PubMed), Lilacs (via BVS) and ScienceDirect followed by a complementary search of references of included studies, Google Scholar and conference abstracts...
February 22, 2018: Expert Review of Pharmacoeconomics & Outcomes Research
Kwang Woo Ahn, Soyoung Kim
We study the group bridge and the adaptive group bridge penalties for competing risks quantile regression with group variables. While the group bridge consistently identifies nonzero group variables, the adaptive group bridge consistently selects variables not only at group level but also at within-group level. We allow the number of covariates to diverge as the sample size increases. The oracle property for both methods is also studied. The performance of the group bridge and the adaptive group bridge is compared in simulation and in a real data analysis...
February 21, 2018: Statistics in Medicine
Qijun Li, Ming Zhou, Mingyang Yang, Qingfeng Yang, Zhixun Zhang, Jing Shi
Phosphorescence shows great potential for application in bioimaging and ion detection because of its long-lived luminescence and high signal-to-noise ratio, but establishing phosphorescence emission in aqueous environments remains a challenge. Herein, we present a general design strategy that effectively promotes phosphorescence by utilising water molecules to construct hydrogen-bonded networks between carbon dots (CDs) and cyanuric acid (CA). Interestingly, water molecules not only cause no phosphorescence quenching but also greatly enhance the phosphorescence emission...
February 21, 2018: Nature Communications
Stefanie Dehnen, Bastian Weinert, Stefan Mitzinger
This review article provides a survey of contemporary investigations on main group metal cluster formation, addressing homo- and heterometallic clusters (including small numbers of transition metal atoms) with or without an external ligand shell, thereby excluding clusters with non-metal atoms as bridging ligands. Most of the studies reflected herein represent insights into the formation of intermediates from the starting material, or the final cluster formation from established intermediates. In rare cases, the entire process was suggested as a result of comprehensive, multi-method elucidations...
February 21, 2018: Chemistry: a European Journal
Qiang Guo, Bin Huang, Jingdong Cheng, Manuel Seefelder, Tatjana Engler, Günter Pfeifer, Patrick Oeckl, Markus Otto, Franziska Moser, Melanie Maurer, Alexander Pautsch, Wolfgang Baumeister, Rubén Fernández-Busnadiego, Stefan Kochanek
Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development and is involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and the regulation of transcription. Although an integrative understanding of the biological functions of HTT is lacking, the large number of identified HTT interactors suggests that it serves as a protein-protein interaction hub. Furthermore, Huntington's disease is caused by a mutation in the HTT gene, resulting in a pathogenic expansion of a polyglutamine repeat at the amino terminus of HTT...
February 21, 2018: Nature
Gianluca Colella, Flavio Fazioli, Michele Gallo, Annarosaria De Chiara, Gaetano Apice, Carlo Ruosi, Amelia Cimmino, Filomena de Nigris
Cancer treatment is rapidly evolving toward personalized medicine, which takes into account the individual molecular and genetic variability of tumors. Sophisticated new in vitro disease models, such as three-dimensional cell cultures, may provide a tool for genetic, epigenetic, biomedical, and pharmacological research, and help determine the most promising individual treatment. Sarcomas, malignant neoplasms originating from mesenchymal cells, may have a multitude of genomic aberrations that give rise to more than 70 different histopathological subtypes...
February 21, 2018: International Journal of Molecular Sciences
N M Vorobyeva
The article contains an outline of the 2017 ACC Expert Consensus Decision Pathway for Periprocedural Management of Anticoagulation in Patients With Nonvalvular Atrial Fibrillation. This document considers in detail problems of necessity and safety of temporary interrupting of anticoagulation for the period of procedure, main principles of interruption and restarting anticoagulant therapy after procedure, indications to the transitional (bridging) therapy in the periprocedural period, as well as possible strategies of periprocedural management of patients in dependence of risk of bleeding and thromboembolic complications...
February 2018: Kardiologiia
Dong Peng, Lei Yin, Peng Hu, Bao Li, Zhong-Wen Ouyang, Gui-Lin Zhuang, Zhenxing Wang
By utilizing a preselected functional ligand produced by 1H-imidazole-4,5-dicarboxylic acid, three isostructural lanthanide coordination polymers (CPs), denoted as {[Ln2 (OH)2 (L)2 ]·(DMF)·(H2 O)4 }n (Ln = Gd (1), Eu (2), Dy (3); L = 1-(4-carboxybenzyl)imidazole-4-carboxylic acid), containing a 1D infinite [Ln4 (OH)4 ] subchain have been successfully constructed. The highly connected mode between the multifunctional ligand and 1D building units is responsible for the exceptional chemical stability of three lanthanide CPs...
February 21, 2018: Inorganic Chemistry
Graham King, Jennifer R Soliz, Wesley O Gordon
Analysis of X-ray pair distribution function data has provided a detailed picture of the local structure of amorphous Zr(OH)4 and its thermal decomposition into ZrO2 . In the untreated phase, the Zr atoms tend to be coordinated by six or seven oxygen atoms. The Zr centered polyhedra connect to each other primarily by sharing edges, but also with a significant amount of corner sharing, to form two-dimensional sheets in which the Zr are connected to an average of about five other Zr. This local structure is related to the structure of monoclinic ZrO2 and can be derived from it by removing certain Zr neighbors to form sheets and reduce the corner to edge sharing ratio...
February 21, 2018: Inorganic Chemistry
Sarah Rhea, Arlene C Seña, Alison Hilton, Christopher B Hurt, David Wohl, Aaron Fleischauer
Guidance about integration of comprehensive hepatitis C virus (HCV)-related services in sexually transmitted disease (STD) clinics is limited. We evaluated a federally-funded HCV testing and linkage-to-care program at an STD clinic in Durham County, North Carolina. During December 10, 2012-March 31, 2015, the program tested 733 patients for HCV who reported ≥1 HCV risk factor; 81 (11%) were HCV-infected (i.e., HCV antibody-positive and HCV ribonucleic acid-positive). Fifty-one infected patients (63%) were linked to care...
October 19, 2017: Sexually Transmitted Diseases
Paul A Hoskisson
Diphtheria AB toxin mode of action. The diphtheria AB exotoxin consists of two polypeptide chains - A and B which are linked by a disulfide bridge. The B chain binds to the heparin-binding epidermal growth factor precursor on eukaryotic cells and is endocytosed. Acidification of the endosome results in a conformational change to the A and B chains and breaking of the disulphide bridge. The B chain remains in the endosome, but the A chain is translocated to the cytoplasm where it ADP-ribosylates host eEF-2, blocking protein synthesis which leads to cell death...
February 21, 2018: Microbiology
Bert A 't Hart, Jon D Laman, Yolanda S Kap
The translation of scientific discoveries made in animal models into effective treatments for patients often fails, indicating that currently used disease models in preclinical research are insufficiently predictive for clinical success. An often-used model in the preclinical research of autoimmune neurological diseases, multiple sclerosis in particular, is experimental autoimmune encephalomyelitis (EAE). Most EAE models are based on genetically susceptible inbred/SPF mouse strains used at adolescent age (10-12 weeks), which lack exposure to genetic and microbial factors which shape the human immune system...
February 21, 2018: Expert Opinion on Drug Discovery
Carlo U Perotto, Charlene L Sodipo, Graham J Jones, Jeremiah P Tidey, Alexander J Blake, William Lewis, E Stephen Davies, Jonathan McMaster, Martin Schröder
The development of synthetic analogs of the active sites of [NiFe] hydrogenases remains challenging, and, in spite of the number of complexes featuring a [NiFe] center, those featuring CO and CN- ligands at the Fe center are under-represented. We report herein the synthesis of three bimetallic [NiFe] complexes [Ni(N2 S2 )Fe(CO)2 (CN)2 ], [Ni(S4 )Fe(CO)2 (CN)2 ], and [Ni(N2 S3 )Fe(CO)2 (CN)2 ] that each contain a Ni center that bridges through two thiolato S donors to a {Fe(CO)2 (CN)2 } unit. X-ray crystallographic studies on [Ni(N2 S3 )Fe(CO)2 (CN)2 ], supported by DFT calculations, are consistent with a solid-state structure containing distinct molecules in the singlet (S = 0) and triplet (S = 1) states...
February 21, 2018: Inorganic Chemistry
Anne Elisabeth E Berns, Herbert Philipp, Hans Lewandowski, Jeong-Heui Choi, Marc Lamshöft, Hans-Dieter Narres
The extensive use of sulfonamides (SNs) in animal husbandry has led to an unintentional widespread occurrence in several environmental compartments. The implementation of regulations and management recommendations to reduce the potential risk of development of antibiotic resistances necessitates detailed knowledge on their fate in soil. We present results from two independent incubation studies of15 N-labeled sulfadiazines (SDZ) which focused on identifying binding types in bound residues. In the first study15 N-amino labeled SDZ was incubated with two previously isolated humic acids in the presence and absence of Trametes versicolor laccase, while in the second study15 N-double-labeled SDZ was incubated with a typical agricultural Luvisol and isolated the humic acid fraction after sequential extraction of the soil...
February 21, 2018: Environmental Science & Technology
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