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Maarten Boers, Jasvinder A Singh, Stacey S Cofield, S Louis Bridges, Larry W Moreland, James R O'Dell, Hongsheng Wu, Sarah Leatherman, Jeffrey R Curtis
INTRODUCTION: The Outcome Measures in Rheumatology (OMERACT) '3x3' method analyzes the occurrence of benefit and harm simultaneously at the individual patient level. We applied this method to two recent rheumatoid arthritis (RA) trial datasets. METHODS: Treatment of Early Aggressive RA (TEAR) and the RA Comparison of Active Therapies (RACAT) randomized trial outcomes for safety were defined according to OMERACT as no events, non-serious events, and serious events...
April 25, 2018: Arthritis Care & Research
Martin Vallon, Christian Dietzen, Silke Laucht, Jan-Dieter Ludwigs
An assessment of potential risks of pesticides on wildlife is required during the process of product registration within Europe, because of the importance of agricultural landscapes as wildlife habitats. Despite their peculiarity and their specific role as artificial wetlands, rice paddies are to date pooled with cereals in guidance documents on how to conduct risk assessments for birds and mammals in Europe. Hence, the focal species currently considered in risk assessments for rice paddies are those known from cereal fields and can therefore be expected to differ significantly from the species actually occurring in the wet environments of rice paddies...
April 25, 2018: Integrated Environmental Assessment and Management
Fumihiko Taya, Stavros I Dimitriadis, Andrei Dragomir, Julian Lim, Yu Sun, Kian Foong Wong, Nitish V Thakor, Anastasios Bezerianos
Fronto-parietal subnetworks were revealed to compensate for cognitive decline due to mental fatigue by community structure analysis. Here, we investigate changes in topology of subnetworks of resting-state fMRI networks due to mental fatigue induced by prolonged performance of a cognitively demanding task, and their associations with cognitive decline. As it is well established that brain networks have modular organization, community structure analyses can provide valuable information about mesoscale network organization and serve as a bridge between standard fMRI approaches and brain connectomics that quantify the topology of whole brain networks...
April 24, 2018: Human Brain Mapping
Joan Soldevila-Sanmartín, Teresa Calvet, Merce Font-Bardia, Concepción Domingo, José A Ayllón, Josefina Pons
The reaction of copper(ii) acetate monohydrate with p-hydroxycinnamic acid (HpOHcinn) and different pyridine derivatives (4-tert-butylpyridine, 4-tBupy; 4-acetylpyridine, 4-Acpy; 3-phenylpyridine, 3-Phpy; 4-phenylpyridine, 4-Phpy) was essayed in methanol solvent at room temperature. The crystal structures of the resulting compounds were elucidated. Their analysis shows that the choice of pyridine ligands determines different coordination modes of the pOHcinn ligand and the Cu(ii) coordination, nuclearity and geometry...
April 25, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Changcheng Tang, Xingxing Jiang, Shu Guo, Mingjun Xia, Lijuan Liu, Xiaoyang Wang, Zheshuai Lin, Chuangtian Chen
A new fluorocarbonate, Na3Zn2(CO3)3F, was synthesized using a subcritical hydrothermal method. Na3Zn2(CO3)3F crystallizes in the space group C2/c with a sandwich-like framework in which the stacked [Zn(CO3)]∞ layers are connected with one another by bridging F atoms and [CO3] groups alternately. Interestingly, each Zn atom is surrounded by one F atom and four O atoms, forming a distorted [ZnO4F] trigonal bipyramid, which is observed for the first time in the carbonate system. Na3Zn2(CO3)3F has high transparency in a wide spectral region ranging from UV to mid IR with a short ultraviolet absorption edge (∼213 nm)...
April 25, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Theodore W Laetsch, Angshumoy Roy, Lin Xu, Jennifer O Black, Cheryl M Coffin, Yueh-Yun Chi, Jing Tian, Sheri L Spunt, Douglas S Hawkins, Julia A Bridge, D Williams Parsons, Stephen X Skapek
PURPOSE: A comprehensive analysis of the genomics of undifferentiated sarcomas (UDS) is lacking.  We analyzed copy number alterations and fusion status in patients with UDS prospectively treated on Children's Oncology Group protocol ARST0332. EXPERIMENTAL DESIGN: Copy number alterations were assessed by Oncoscan FFPE Express on 32 UDS. Whole-exome and transcriptome libraries from 8 tumors with sufficient archived material were sequenced on HiSeq (2x100 bp). Targeted RNA-sequencing using Archer chemistry was performed on two additional cases...
April 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Hao Li, Fang Fang, Yunqi Liu, Liangmin Xue, Meng Wang, Ying Guo, Xiaowei Wang, Chao Tian, Junyi Liu, Zhili Zhang
Bridge homologation of the previously reported nonclassical two-carbon-bridged antifolate, 2,4-diamino-6-phenethylpyrido[3,2-d]pyrimidine (wm-5a), afforded the three-, four- and five-carbon-bridged antifolate analogues 3.1-3.5, 4.1-4.2 and 5.1-5.5. The target compounds, with substituents at various positions on the carbon bridges, were efficiently synthesized by aldol condensation or Wittig reaction and followed by reduction. Elongation of the two-carbon bridge to three-, four- or five-carbon bridges, and also saturation of the carbon bridges, provided compounds with good inhibitory activity against recombinant human DHFR (rhDHFR)...
April 19, 2018: Bioorganic & Medicinal Chemistry
Melvyn Zhang, Yi Yang, Song Guo, Chris Cheok, Kim Eng Wong, Gomathinayagam Kandasami
Given that technology has greatly facilitated easier access to gambling in previous years, it is timely to look in-depth into online gambling activities and behaviors. There have been several studies that examined online gambling. However, most of the current studies to date have focused on determining the prevalence and the epidemiology of problem gambling arising from online gambling in Western cohorts. There remains a paucity of research looking at the problem of online gambling among Asian individuals. The objectives of the current study are to elucidate the characteristics of online gambling among an Asian cohort and to explore the harm associated with online gambling and the potential mechanisms by which harm associated with online gambling could be minimized...
April 23, 2018: International Journal of Environmental Research and Public Health
Mathias Jaschhof, Daseul Ham, Yeon Jae Bae
The genus Loboplusia was recently introduced for a remarkable species of Diallactiini from the cloud forest of Costa Rica (Jaschhof 2016). Males of that species, Loboplusia zurqui Jaschhof, 2016, were found to differ fundamentally from other Diallactiini, with the following traits defining the genus. The scutum is provided with a bright membranous patch called the prescutellar window; setae on the legs, especially the tarsi, are fringed; the gonostylus consists of two lobes (not a single lobe as is the basic pattern in Diallactiini); and the bridge connecting the gonocoxites ventrobasally is markedly shortened (Jaschhof 2016: fig...
March 20, 2018: Zootaxa
Oleksandr Varga, Alexey Reshchikov, Filippo di Giovanni
Brachyzapus Gauld Dubois, 2006 is a small genus belonging to the Polysphincta genus-group of the subfamily Pimplinae, with nine known species worldwide (Uchida Momoi, 1958; Yu et al., 2012; Pham et al., 2012). The genus can be recognized by twisted mandibles, a very weakly convex and rather long clypeus with quite well-defined angulation laterally, elongate lower face, sparse pubescence on the eyes, hind coxal cavities separated from the metasoma insertion by a very strong sclerotized bridge, and the lack of a basal lobe on the ovipositor (Gauld Dubois, 2006)...
February 5, 2018: Zootaxa
Stéphane Frémont, Arnaud Echard
Cells don't simply separate at cytokinesis. While furrow contraction critically relies on myosin-II and F-actin, post-furrowing steps are less understood but involve the constriction of ESCRT-III polymer-dependent helices on the side of the midbody, which likely drive final abscission. The first evidence that animal cell cytokinesis requires membrane traffic, as in plant cells, was provided about 15 years ago. Since then, it has become increasingly clear that fusion of vesicles to the cytokinetic furrow is essential in large embryonic cells, and that membrane traffic within the intercellular bridge is crucial for its stability and successful abscission in all animal cells...
April 23, 2018: Current Biology: CB
Xiaoyan Zhang, Leibin Wang, Behnam Lak, Jie Li, Eija Jokitalo, Yanzhuang Wang
The Golgi apparatus is the central hub for protein trafficking and glycosylation in the secretory pathway. However, how the Golgi responds to glucose deprivation is so far unknown. Here, we report that GRASP55, the Golgi stacking protein located in medial- and trans-Golgi cisternae, is O-GlcNAcylated by the O-GlcNAc transferase OGT under growth conditions. Glucose deprivation reduces GRASP55 O-GlcNAcylation. De-O-GlcNAcylated GRASP55 forms puncta outside of the Golgi area, which co-localize with autophagosomes and late endosomes/lysosomes...
April 23, 2018: Developmental Cell
Lorena Tremiño, Alicia Forcada-Nadal, Vicente Rubio
Vitamin B6 -dependent genetic epilepsy was recently associated to mutations in PLPBP (previously PROSC), the human version of the widespread COG0325 gene that encodes TIM-barrel-like pyridoxal phosphate (PLP)-containing proteins of unclear function. We produced recombinantly, purified and characterized human PROSC (called now PLPHP) and its six missense mutants reported in epileptic patients. Normal PLPHP is largely a monomer with PLP bound through a Schiff-base linkage. The PLP-targeting antibiotic D-cycloserine decreased the PLP-bound peak as expected for pseudo-first-order reaction...
April 24, 2018: Human Mutation
Massimo Romanò
Heart failure (HF) is one of the leading causes of hospitalization in high-income countries and has a profound negative impact on quality of life. In the United States there are more than 900,000 new cases per year and over one million hospital admissions with a primary diagnosis of HF. A prevalence of 6,500,000 cases (2.2% of the population of aged >20 years) was estimated for the US in 2014, in which there were 300,000 related deaths. Although survival has increased, thanks to the pharmacological and non pharmacological therapy, roughly 50% of HF patients die within 5 years of being diagnosed...
April 2018: Recenti Progressi in Medicina
Ammon M Fager, Elizabeth Deans, Andra H James
The perioperative management of patients taking antithrombotic or antiplatelet medications is based on an assessment of the individual patient's risk for thrombosis or bleeding, the specific medication involved, and the nature of the planned procedure. This article describes specific strategies for whether and how these medications should be interrupted before gynecologic procedures, when they can be restarted following the procedure, and whether bridging therapy should be considered.
June 2018: Clinical Obstetrics and Gynecology
Silvia Müller-Hagedorn, Cornelia Wiechers, Jörg Arand, Wolfgang Buchenau, Margit Bacher, Michael Krimmel, Siegmar Reinert, Christian F Poets
BACKGROUND: Infants and children with syndromic craniosynostosis (SCS), such as Apert-, Crouzon- or Pfeiffer syndrome, are prone to sleep disordered breathing (SDB) including obstructive sleep apnea and upper airway resistance syndrome (OSAS, UARS), potentially leading to tracheostomy. We modified the Tübingen Palatal Plate (TPP), an oral appliance with a velar extension effectively treating airway obstruction in Robin sequence, by attaching a tube to its velar extension to bridge the narrow pharyngeal airway in SCS patients...
April 23, 2018: Orphanet Journal of Rare Diseases
Shanshan Ma, Aimin Yu, Lei Zhang, Xiangtai Meng
The reaction of thioaurones derivatives with allenoate catalyzed by tris(4-methoxyphenyl)phosphane (P(4-MeOC6H4)3) resulted in a domino annulation reaction to produce a benzothiophene fused bridged bicyclic ring, with 40% to 91% yields. The advantages of the methodology include diastereoselective formation of a bridged bicyclic ring in a single step, very mild reaction conditions and success resulting from a broad functional group. The proposed mechanism was tested and supported by DFT calculations.
April 24, 2018: Journal of Organic Chemistry
Juan Pablo Zubimendi, Andrea Martinatto, Maria Pía Valacco, Silvia Moreno, Carlos Santiago Andreo, María Fabiana Drincovich, Marcos Ariel Tronconi
Arabidopsis thaliana possesses two fumarase genes (FUM), AtFUM1 (At2g47510) encoding for the mitochondrial Krebs cycle-associated enzyme and AtFUM2 (At5g50950) for the cytosolic isoform required for fumarate massive accumulation. Here, the comprehensive biochemical studies of AtFUM1 and AtFUM2 shows that they are active enzymes with similar kinetic parameters but differential regulation. For both enzymes, fumarate hydratase (FH) activity is favored over the malate dehydratase (MD) activity; however, MD is the most regulated activity with several allosteric activators...
April 24, 2018: FEBS Journal
Stefanie Brehmer, Mario Alexander Grimm, Alex Förster, Marcel Seiz-Rosenhagen, Grit Welzel, Florian Stieler, Frederik Wenz, Christoph Groden, Sabine Mai, Daniel Hänggi, Frank Anton Giordano
BACKGROUND: Glioblastoma (GBM) is the most common malignant brain tumor in adult patients. Tumor recurrence commonly occurs around the resection cavity, especially after subtotal resection (STR). Consequently, the extent of resection correlates with overall survival (OS), suggesting that depletion of postoperative tumor remnants will improve outcome. OBJECTIVE: To assess safety and efficacy of adding stereotactic radiosurgery (SRS) to the standard treatment of GBM in patients with postoperative residual tumor...
April 24, 2018: Neurosurgery
Amel Bekkar, Anne Estreicher, Anne Niknejad, Cristina Casals-Casas, Alan Bridge, Ioannis Xenarios, Julien Dorier, Isaac Crespo
January 1, 2018: Database: the Journal of Biological Databases and Curation
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