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https://www.readbyqxmd.com/read/28823047/knowledge-that-acts-evaluating-the-outcomes-of-a-knowledge-brokering-intervention-in-western-australia-s-ningaloo-region
#1
Kelly Chapman, Fabio Boschetti, Elizabeth Fulton, Pierre Horwitz, Tod Jones, Pascal Scherrer, Geoff Syme
Knowledge exchange involves a suite of strategies used to bridge the divides between research, policy and practice. The literature is increasingly focused on the notion that knowledge generated by research is more useful when there is significant interaction and knowledge sharing between researchers and research recipients (i.e., stakeholders). This is exemplified by increasing calls for the use of knowledge brokers to facilitate interaction and flow of information between scientists and stakeholder groups, and the integration of scientific and local knowledge...
August 19, 2017: Environmental Management
https://www.readbyqxmd.com/read/28822869/a-review-of-terrorism-and-its-reduction-of-the-gender-ratio-at-birth-after-seasonal-adjustment
#2
Victor Grech, Dorota Zammit
BACKGROUND: Males are born in excess of females, a ratio expressed as M/T (males:total births). The ratio exhibits seasonal variation. Furthermore, acute stressful events may result in a transient dip in male births due to excess foetal losses, reducing M/T. AIMS: This study was carried out in order to identify significant M/T dips after adjusting for seasonality. STUDY DESIGN: Live births by gender and month were sought for acute stressful events...
August 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28822737/printing-nature-unraveling-the-role-of-nacre-s-mineral-bridges
#3
Grace X Gu, Flavia Libonati, Susan D Wettermark, Markus J Buehler
Creating materials with strength and toughness has been a long-sought goal. Conventional engineering materials often face a trade-off between strength and toughness, prompting researchers seeking to overcome these limitations to explore more sophisticated materials, such as composites. This paradigm shift in material design is spurred by nature, which exhibits a plethora of heterogeneous materials that offer outstanding material properties, and many natural materials are widely regarded as examples of high-performing hybrid materials...
May 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28822566/human-pulp-responses-to-partial-pulpotomy-treatment-with-theracal-as-compared-with-biodentine-and-proroot-mta-a-clinical-trial
#4
Hengameh Bakhtiar, Mohammad Hossein Nekoofar, Pouyan Aminishakib, Fatemeh Abedi, Fereshteh Naghi Moosavi, Ehsan Esnaashari, Arash Azizi, Samar Esmailian, Mohammad Reza Ellini, Vahid Mesgarzadeh, Mehdi Sezavar, Imad About
INTRODUCTION: Questions exist regarding the efficacy of resin-containing materials such as TheraCal directly applied on the pulp. This study sought to investigate the clinical efficacy of TheraCal as compared with Biodentine and ProRoot mineral trioxide aggregate (MTA) for partial pulpotomy. METHODS: In this clinical trial, partial pulpotomy was performed for 27 sound human maxillary and mandibular third molars scheduled for extraction. The teeth were randomly divided into 3 groups (n = 9) and underwent partial pulpotomy with TheraCal, Biodentine, and ProRoot MTA...
August 16, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28822399/chest-tube-removal-in-simple-pneumothorax-does-water-seal-duration-matter
#5
Lindsay C Bridges, Danny J Torrent, Catalina Mosquera, Michael R Bard
Timing of chest tube (CT) removal after transition from suction to water-seal (WS) varies when treating traumatic simple pneumothoraces (PTXs). Longer periods of WS may identify slow-occurring PTXs reducing CT replacement, whereas shorter periods may expedite patient disposition and have associated cost savings. Prior studies support the need for an interval of WS. We compare durations of WS, looking at rates of CT reinsertion. A 10-year retrospective review on trauma patients with a simple PTX requiring a CT was performed...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822354/3d-brain-organoids-derived-from-pluripotent-stem-cells-promising-experimental-models-for-brain-development-and-neurodegenerative-disorders
#6
REVIEW
Chun-Ting Lee, Raphael M Bendriem, Wells W Wu, Rong-Fong Shen
Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain's 3D cytoarchitectural arrangement and provide new opportunities to explore disease pathogenesis in the human brain. Human iPSC (hiPSC) reprogramming methods, combined with 3D brain organoid tools, may allow patient-derived organoids to serve as a preclinical platform to bridge the translational gap between animal models and human clinical trials...
August 20, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28822116/interactions-between-variation-in-candidate-genes-and-environmental-factors-in-the-etiology-of-schizophrenia-and-bipolar-disorder-a-systematic-review
#7
REVIEW
Błażej Misiak, Filip Stramecki, Łukasz Gawęda, Katarzyna Prochwicz, Maria M Sąsiadek, Ahmed A Moustafa, Dorota Frydecka
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk variants with small effect sizes, which might explain only a minor part of susceptibility. On the other site, numerous environmental factors have been found to play an important role in their causality. Therefore, in recent years, several studies focused on gene × environment interactions that are believed to bridge the gap between genetic underpinnings and environmental insults...
August 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28821822/bladder-cancer-treatment-response-assessment-in-ct-using-radiomics-with-deep-learning
#8
Kenny H Cha, Lubomir Hadjiiski, Heang-Ping Chan, Alon Z Weizer, Ajjai Alva, Richard H Cohan, Elaine M Caoili, Chintana Paramagul, Ravi K Samala
Cross-sectional X-ray imaging has become the standard for staging most solid organ malignancies. However, for some malignancies such as urinary bladder cancer, the ability to accurately assess local extent of the disease and understand response to systemic chemotherapy is limited with current imaging approaches. In this study, we explored the feasibility that radiomics-based predictive models using pre- and post-treatment computed tomography (CT) images might be able to distinguish between bladder cancers with and without complete chemotherapy responses...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820938/multi-scale-simulation-of-receptor-drug-association-kinetics-application-to-neuramidase-inhibitors
#9
Fabian Zeller, Manuel P Luitz, Rainer Bomblies, Martin Zacharias
A detailed understanding of the drug-receptor association process is of fundamental importance for drug design. Due to the long timescales of typical binding kinetics, the atomistic simulation of the ligand traveling from bulk solution into the binding site is still computationally challenging. In this work, we apply a multi-scale approach of combined molecular dynamics (MD) and Brownian dynamics (BD) simulations to investigate association pathway ensembles for the two prominent H1N1 neuraminidase inhibitors oseltamivir and zanamivir...
August 18, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28820592/copper-i-no-g-reductive-coupling-producing-a-trans-hyponitrite-bridged-dicopper-ii-complex-redox-reversal-giving-copper-i-no-g-disproportionation
#10
Gayan B Wijeratne, Shabnam Hematian, Maxime A Siegler, Kenneth D Karlin
A copper complex, [CuI(tmpa)(MeCN)]+, effectively reductively couples NO(g) at RT in methanol, giving a structurally characterized hyponitrito-dicopper(II) adduct. Hydrogen-bonding from MeOH is critical for the hyponitrite complex formation and stabilization. This complex exhibits the reverse redox process in aprotic solvents, giving CuI + NO, leading to CuI-mediated NO disproportionation. The relation-ship of this chemistry to biological iron and/or copper mediated NO reductive coupling to give N2O(g) is discussed...
August 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28820525/the-content-validity-of-a-chemotherapy-induced-peripheral-neuropathy-patient-reported-outcome-measure
#11
Ellen M Lavoie Smith, Rylie Haupt, James P Kelly, Deborah Lee, Grace Kanzawa-Lee, Robert Knoerl, Celia Bridges, Paola Alberti, Nusara Prasertsri, Clare Donohoe
PURPOSE/OBJECTIVES: To test the content validity of a 16-item version of the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Chemotherapy-Induced Peripheral Neuropathy (QLQ-CIPN20). 
. RESEARCH APPROACH: Cross-sectional, prospective, qualitative design. 
. SETTING: Six outpatient oncology clinics within the University of Michigan Health System's comprehensive cancer center in Ann Arbor. 
...
September 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28820218/photophysical-characterization-and-time-resolved-spectroscopy-of-a-anthradithiophene-dimer-exploring-the-role-of-conformation-in-singlet-fission
#12
Jacob C Dean, Ruomeng Zhang, Rawad K Hallani, Ryan D Pensack, Samuel N Sanders, Daniel G Oblinsky, Sean R Parkin, Luis M Campos, John E Anthony, Gregory D Scholes
Quantitative singlet fission has been observed for a variety of acene derivatives such as tetracene and pentacene, and efforts to extend the library of singlet fission compounds is of current interest. Preliminary calculations suggest anthradithiophenes exhibit significant exothermicity between the first optically-allowed singlet state, S1, and 2 × T1 with an energy difference of >5000 cm(-1). Given the fulfillment of this ingredient for singlet fission, here we investigate the singlet fission capability of a difluorinated anthradithiophene dimer (2ADT) covalently linked by a (dimethylsilyl)ethane bridge and derivatized by triisobutylsilylethynyl (TIBS) groups...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28820215/how-exfoliated-graphene-oxide-nanosheets-organize-at-the-water-interface-evidence-for-a-spontaneous-bilayer-self-assembly
#13
Nathalie Bonatout, François Muller, Philippe Fontaine, Ignacio Gascon, Oleg Konovalov, Michel Goldmann
In this study, we have characterized graphene oxide films formed at the air-water interface by X-ray reflectivity and grazing incidence X-ray diffraction using synchrotron sources. Surprisingly, the results of both measurements show that at non zero surface pressures, the film is organized as a bilayer of sheets interfaced between air and water with water molecule bridges. Such a spontaneous bilayer structure and its evolution with respect to the surface pressure has been observed for the first time. These results should allow precise control of the density of sheets deposited on the substrate when these films are transferred through the Langmuir Blodgett or Schaefer procedures...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28820213/chip-scale-alignment-of-long-dna-nanofibers-on-a-patterned-self-assembled-monolayer
#14
J Xia, M Su
Controlled alignment of long DNA nanofibers is challenging. This communication reports a method to align human genomic DNA with nearly unlimited length using lithographically produced micro-patterns of self-assembled monolayers (SAMs) with positively charged terminal groups. The micro-patterns act as local DNA reservoirs to supply DNAs for nanofiber formation, and can also stretch and align DNA nanofibers to form an ordered array by controlling the dewetting profile. By reducing the size and inter-patch distance of a micro-patch, a nearly uniform array of long DNA nanofibers can be patterned over a large area...
August 18, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28820211/reactivity-of-the-parent-amido-complexes-of-iridium-with-olefins-c-nh2-bond-formation-versus-c-h-activation
#15
Inmaculada Mena, Pilar García-Orduña, Víctor Polo, Fernando J Lahoz, Miguel A Casado, Luis A Oro
Herein we report on the different chemical reactivity displayed by two mononuclear terminal amido compounds depending on the nature of the coordinated diene. Hence, treatment of amido-bridged iridium complexes [{Ir(μ-NH2)(tfbb)}3] (1; tfbb = tetrafluorobenzobarrelene) with dppp (dppp = bis(diphenylphosphane)propane) leads to the rupture of the amido bridges forming the mononuclear terminal amido compound [Ir(NH2)(dppp)(tfbb)] (3) in the first stage. On changing the reaction conditions, the formation of a C-NH2 bond between the amido moiety and the coordinated diene is observed and a new dinuclear complex [{Ir(1,2-η(2)-4-κ-C12H8F4N)(dppp)}2(μ-dppp)] (4) has been isolated...
August 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28820191/comparative-photophysics-and-ultrafast-dynamics-of-dimethylaminochalcone-and-a-structurally-rigid-derivative-experimental-identification-of-tict-coordinate
#16
Rajib Ghosh, Biswajit Manna
Photophysical parameters and ultrafast dynamics of dimethylaminochalone (DMAC-A) have been compared with a structurally bridged analogue (namely, c-DMAC) in solvents of varying polarities. Conformational locking of the single bond connecting the donor and acceptor groups in c-DMAC arrests the twisted intramolecular charge transfer (TICT) relaxation and consequently the photophysical parameters such as fluorescence yield, fluorescence lifetime and triplet yield change significantly. The intramolecular charge transfer character of the LE state is found to be unaffected by conformational restriction...
August 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28819771/the-impact-of-bridging-lrt-on-survival-in-patients-listed-for-liver-transplantation
#17
Peiman Habibollahi, Stephen Hunt, Terence Gade, Mandeep S Dagli, Jeffrey I Mondschein, Deepak Sudheendra, S William Stavropoulos, Michael Soulen, Nadolski Gregory
PURPOSE: Locoregional therapy (LRT) is recommended for certain groups of patients with hepatocellular carcinoma (HCC) listed for orthotopic liver transplantation (OLT) with expected wait times greater than 6 months. A retrospective single-center study was performed to evaluate the effect of LRT on the outcomes of patients with HCC listed for OLT. METHODS: Institutional database was reviewed to identify the patients listed for OLT with HCC (March 1998-December 2010)...
August 17, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28819626/robust-significance-analysis-of-microarrays-by-minimum-%C3%AE-divergence-method
#18
Md Shahjaman, Nishith Kumar, Md Manir Hossain Mollah, Md Shakil Ahmed, Anjuman Ara Begum, S M Shahinul Islam, Md Nurul Haque Mollah
Identification of differentially expressed (DE) genes with two or more conditions is an important task for discovery of few biomarker genes. Significance Analysis of Microarrays (SAM) is a popular statistical approach for identification of DE genes for both small- and large-sample cases. However, it is sensitive to outlying gene expressions and produces low power in presence of outliers. Therefore, in this paper, an attempt is made to robustify the SAM approach using the minimum β-divergence estimators instead of the maximum likelihood estimators of the parameters...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28819594/modified-nicoll-s-graft-for-treatment-of-gap-non-union-of-ulna-a-rare-case-report
#19
Chaitanya Krishna, Jayanta Mondal, Anirudhha Sengupta
INTRODUCTION: Despite the multitude of studies for the treatment of non-unions, no clear criterion has been established for treating a fracture of non-union. Non-union of radius and ulna produces a discrepancy in length which must be restored for adequate rotation and function. Nicoll described a technique of bridging gaps in long bones with solid blocks of cancellous bone and fixing the fragments with metal plates. We utilized modified Nicoll's graft using corticocancellous graft taken from iliac crest...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28819574/sequential-kinase-inhibition-idelalisib-ibrutinib-induces-clinical-remission-in-b-cell-prolymphocytic-leukemia-harboring-a-17p-deletion
#20
H Coelho, M Badior, T Melo
B-cell prolymphocytic leukemia (B-PLL) is a rare lymphoid neoplasm with an aggressive clinical course. Treatment strategies for B-PLL remain to be established, and, until recently, alemtuzumab was the only effective therapeutic option in patients harboring 17p deletions. Herein, we describe, for the first time, a case of B-cell prolymphocytic leukemia harboring a 17p deletion in a 48-year-old man that was successfully treated sequentially with idelalisib-rituximab/ibrutinib followed by allogeneic hematopoietic stem cell transplant (allo-HSCT)...
2017: Case Reports in Hematology
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