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Christiane Ermina Sophia Rudolph, Alexander Katalinic
AIM: Vaccines against human papillomaviruses are covered by statutory health insurances in Germany since March 2007. A reduction of cervical and other HPV-associated cancers is expected. Incidence rates of HPV-associated cancers preceding the introduction of vaccines are unknown. These, however, are important for assessing the effects of HPV vaccines. The aim of the present study was to bridge this knowledge gap. METHODS: Based on cancer registry data from seven federal states, average yearly incidence rates for cervical, anogenital, oropharyngeal cancers and cancers of the oral cavity were calculated for the period 2003 to 2007...
June 22, 2018: Das Gesundheitswesen
Emily J Rogalski, Becky Khayum
Primary progressive aphasia (PPA) is a clinical neurodegenerative dementia syndrome characterized by deficits in spoken and written word retrieval, word usage, and/or word comprehension. Currently, there are no effective treatments to reverse or halt the underlying disease process; however, speech-language therapy may be helpful. The Communication Bridge Care Model was developed to address the unique communication and quality of life needs of individuals living with PPA. The core elements include person-centered care with dyadic instruction for disease education, and counseling, along with tailored levels of impairment- and compensatory-based communication strategy training...
July 2018: Seminars in Speech and Language
Bethany A Matus, Kayla M Bridges, John V Logomarsino
BACKGROUND: Individualized feeding care plans and safe handling of milk (human or formula) are critical in promoting growth, immune function, and neurodevelopment in the preterm infant. Feeding errors and disruptions or limitations to feeding processes in the neonatal intensive care unit (NICU) are associated with negative safety events. Feeding errors include contamination of milk and delivery of incorrect or expired milk and may result in adverse gastrointestinal illnesses. PURPOSE: The purpose of this review was to evaluate the effect(s) of centralized milk preparation, use of trained technicians, use of bar code-scanning software, and collaboration between registered dietitians and registered nurses on feeding safety in the NICU...
June 21, 2018: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Isobel Swinscoe, David M Oliver, Andre S Gilburn, Richard S Quilliam
The sustainable management of recreational beaches is essential for minimising risk of human exposure to microbial pathogens whilst simultaneously maintaining valuable ecosystem services. Decaying seaweed on public beaches is gaining recognition as a substrate for microbial contamination, and is a potentially significant reservoir for human pathogens in close proximity to beach users. Closely associated with beds of decaying seaweed are dense populations of the seaweed fly (Coelopidae), which could influence the spatio-temporal fate of seaweed-associated human pathogens within beach environments...
June 19, 2018: Journal of Environmental Management
Evan M Mistur, Gordon Kingsley, Daniel C Matisoff, Yehyun An
Employing a case of a state transportation agency, we examine how complex institutions which integrate outsourcing within a bureaucratic process adapt to environmental regulatory changes. In 2012, two endangered species of bats were located outside of their established ranges in northern Georgia. These discoveries required the Georgia Department of Transportation (GDOT) to comply with a new set of federal regulations relating to those species when developing its projects. This article examines how GDOT adapted to new and unforeseen regulations in the face of environmental uncertainty...
June 19, 2018: Journal of Environmental Management
Parnaz Borjian Boroujeni, Marjan Sabbaghian, Mehdi Totonchi, Niloofar Sodeifi, Homa Sarkardeh, Azam Samadian, Mohammad Ali Sadighi-Gilani, Hamid Gourabi
OBJECTIVE: Spermatogenesis is a complex process controlled by a plethora of genes. Changes in expression and function of these genes may thus lead to spermatogenic deficiency and male infertility. TEX11, TEX12, TEX14 and TEX15 are germ cell-specific genes expressed in the testis. TEX11, involved in the initiation and maintenance of chromosome synapses in meiotic chromosomes, has been shown to be essential for meiosis and fertility in males. TEX14, a component of intercellular bridges in germ cells, is required for spermatogenesis and fertility...
June 22, 2018: JBRA Assisted Reproduction
Nick John Cave, Janis P Bridges, Karin Weidgraaf, David Granville Thomas
Obesity is highly prevalent in pet cats (Felis silvestris catus) and is associated with several comorbidities, yet very little is understood about the early life risk factors. The aim of this study was to develop a mathematical model that describes growth in cats, to determine which early life variables were associated with being overweight in adulthood and to identify when during life the overweight phenotype developed in a colony of cats. We used pedigree, birth and growth data of 212 colony cats that were fed ad libitum from weaning...
June 22, 2018: Journal of Animal Physiology and Animal Nutrition
Yu Zhang, Xinxin Wang, Yaorong Wang, Dan Yuan, Yingming Yao
Zirconium complexes stabilized by amine-bridged bis(phenolato) ligands showed good activity and chemo-selectivity in catalyzing intermolecular hydrophosphination of C-C multiple bonds with primary phosphines under mild conditions. A broad range of alkenes and alkynes underwent a mono-addition reaction with phenylphosphine, which generated secondary phosphines in 39-99% yields and >7 : 1 selectivity (over double hydrophosphination).
June 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Prithwish Mahapatra, Michael G B Drew, Ashutosh Ghosh
A new mononuclear Ni(II) complex [NiL] (1) of an unsymmetrically dicondensed N2 O3 donor ligand, H2 L ( N-α-methylsalicylidene- N'-3-methoxysalicylidene-1,3-propanediamine), has been synthesized. Complex 1 on reaction with Mn(ClO4 )2 ·6H2 O and NaN3 in different molar ratios yielded three novel heterometallic NiII -MnII complexes, [(NiL)2 Mn(N3 )](ClO4 ) (2), [(NiL)2 Mn2 (N3 )2 (μ1,1 -N3 )2 (CH3 OH)2 ] (3), and [{(NiL)2 Mn}2 (μ1,3 -N3 )(H2 O)]·(CH3 OH),(ClO4 )3 (4). The single crystal structure analyses show a trinuclear NiII 2 MnII structure for complex 2 and a tetranuclear NiII 2 MnII 2 structure where two dinuclear NiII MnII units are connected via μ1,1 -azido and phenoxido bridges for complex 3...
June 22, 2018: Inorganic Chemistry
Vance G Nielsen, Timothy D Ward, Paul M Ford
INTRODUCTION: Copper poisoning is associated with severe multiorgan injury and potentially death if chelation therapy is not administered. Of interest, while important gastrointestinal and urinary tract hemorrhage is associated with copper poisoning, very little is known concerning the nature of copper induced coagulopathy. METHODS: Using thrombelastography, we assessed changes in coagulation kinetics in human plasma following exposure to copper concentrations encountered during poisoning...
June 21, 2018: Journal of Thrombosis and Thrombolysis
Sebastian Lotzien, Clemens Hoberg, Martin F Hoffmann, Thomas A Schildhauer
PURPOSE: The number of total knee arthroplasties (TKA) increased rapidly. In conjunction with higher implantation rates, periprosthetic femur fractures following TKA are also gradually increasing. Purpose of this study was to evaluate polyaxial locking plate treatment of periprosthetic femoral fractures with retained total knee replacement using polyaxial locking plates in regard to quality of life, functional outcome and complications. METHODS: The Study design is a single-center retrospective cohort analysis...
June 22, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Ashley M Butler, Marisa E Hilliard, DeLawnia Comer-HaGans
PURPOSE OF REVIEW: Community-engaged research (CER), which is characterized by collaborations between researchers and community partners, is a promising approach to bridge the gaps in translating research evidence into care settings and to address health disparities. This review describes CER in investigations focused on pediatric diabetes. RECENT FINDINGS: Studies were focused on African American, Hispanic, and Native American youth. Most studies aimed to develop and evaluate preventive interventions for type 2 diabetes...
June 22, 2018: Current Diabetes Reports
Cyriac Abby Philips, Nikhil Phadke, Karthik Ganesan, Shatakshi Ranade, Philip Augustine
INTRODUCTION: Alcohol-induced intestinal dysbiosis is central to the development of the severe alcoholic liver disease. We present the first study to compare outcomes in patients of severe alcoholic hepatitis (SAH) on nutritional therapy, corticosteroids, pentoxifylline, and healthy donor fecal transplantation (FMT) and discuss distinct microbial community and microbiome metabolic functional changes after FMT. METHODS: Out of 1271 liver disease patients, 809 (63...
June 21, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
E Michael Lewiecki, Tomasz Blicharski, Stefan Goemaere, Kurt Lippuner, Paul D Meisner, Paul D Miller, Akimitsu Miyauchi, Judy Maddox, Li Chen, Stephane Horlait
Context: Globally, one in five men over 50 years of age is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and paucity of bone-forming agents for men, there is need for new osteoporosis treatments. Objective: Evaluate the safety and efficacy of romosozumab in men with osteoporosis. Design: Phase 3 randomized placeBo-contRolled double-blind study evaluatIng the efficacy anD safety of romosozumab in treatinG mEn with osteoporosis (BRIDGE; NCT02186171) for 12 months...
June 20, 2018: Journal of Clinical Endocrinology and Metabolism
Jin Li, Su-Ping Deng, Jacob Vieira, James Thomas, Valerio Costa, Ching-San Tseng, Franjo Ivankovic, Alfredo Ciccodicola, Peng Yu
RNA-binding proteins (RBPs) may play a critical role in gene regulation in various diseases or biological processes by controlling post-transcriptional events such as polyadenylation, splicing and mRNA stabilization via binding activities to RNA molecules. Owing to the importance of RBPs in gene regulation, a great number of studies have been conducted, resulting in a large amount of RNA-Seq datasets. However, these datasets usually do not have structured organization of metadata, which limits their potentially wide use...
January 1, 2018: Database: the Journal of Biological Databases and Curation
Kyawzaw Lin, Aung Naing Lin, Won Jun Park, Pwint Phyu Hlaing, Cesar Ayala-Rodriguez
Splenic infarction is an unusual cause for a patient to present with left upper abdomen pain. A 47-year-old woman presented to the emergency department with left upper abdomen pain. She reported that she stopped taking warfarin two days prior to presentation. A physical examination revealed fine crackles within the left lower lobe and significant tenderness within the left upper abdomen. Computed tomography of the abdomen showed mild cardiomegaly with a 2.3 cm calcified thrombus in the left ventricular apex...
April 19, 2018: Curēus
Aina Bernal, Marc Moltó-Abad, Daniel Domínguez, Laura Tusell
Telomere dysfunction drives chromosome instability through endless breakage-fusion-bridge (BFB) cycles that promote the formation of highly rearranged genomes. However, reactivation of telomerase or ALT-pathway is required for genome stabilisation and full malignant transformation. To allow the unrestricted proliferation of cells at risk of transformation, we have established a conditional system of telomere deprotection in p16INK4a -deficient MCF-10A cells with modified checkpoints. After sustained expression of a dominant negative form of the shelterin protein TRF2 (TRF2ΔBΔM ), cells with telomere fusion did progress to anaphase but no signs of ongoing BFB cycles were observed, thus anticipating proliferation defects...
June 5, 2018: Oncotarget
Michael Reidy, Shailesh Kumar, D Eric Anderson, Daniel C Masison
The Hsp90 chaperone is regulated by many co-chaperones that tune its activities, but how they act to coordinate various steps in the reaction cycle is unclear. The primary role of Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Sti1 (Hop in mammals) is to bridge Hsp70 and Hsp90 to facilitate client transfer. Sti1 is not essential, so Hsp90 can interact with Hsp70 in vivo without Sti1. Nevertheless, many Hsp90 mutations make Sti1 necessary for viability, which points to sites of Hsp90 as important for Hsp70 interaction...
June 21, 2018: Genetics
Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting-Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei-Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala-Dilke, Ian Spendlove, Tyson V Sharp
The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is a key contributor to cellular transformation, tumorigenesis and metastasis. As such, HIF degradation under hypoxic conditions is an essential homeostatic and tumour-suppressive mechanism. LIMD1 complexes with PHD2 and VHL in physiological oxygen levels (normoxia) to facilitate proteasomal degradation of the HIF-α subunit...
June 21, 2018: EMBO Molecular Medicine
Paulina J Stanczyk, Monika Seidel, Judith White, Cedric Viero, Christopher H George, Spyros Zissimopoulos, F Anthony Lai
The cardiac muscle ryanodine receptor-Ca2+ release channel (RyR2) constitutes the sarcoplasmic reticulum (SR) Ca2+ efflux mechanism that initiates myocyte contraction, while cardiac myosin binding protein-C (cMyBP-C) mediates regulation of acto-myosin cross-bridge cycling. In this report, we provide the first evidence for the presence of direct interaction between these two proteins, forming a RyR2:cMyBP-C complex. The C-terminus of cMyBP-C binds with the RyR2 N-terminus in mammalian cells and is not mediated by a fibronectin-like domain...
June 21, 2018: Journal of Cell Science
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