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Peter Rieckmann, Diego Centonze, Irina Elovaara, Gavin Giovannoni, Eva Havrdová, Jurg Kesselring, Gisela Kobelt, Dawn Langdon, Sarah A Morrow, Celia Oreja-Guevara, Sven Schippling, Christoph Thalheim, Heidi Thompson, Patrick Vermersch, Karen Aston, Birgit Bauer, Christy Demory, Maria Paz Giambastiani, Jana Hlavacova, Jocelyne Nouvet-Gire, George Pepper, Maija Pontaga, Emma Rogan, Chrystal Rogalski, Pieter van Galen, Ali-Frédéric Ben-Amor
BACKGROUND: Patient engagement is vital in multiple sclerosis (MS) in order to optimise outcomes for patients, society and healthcare systems. It is essential to involve all stakeholders in potential solutions, working in a multidisciplinary way to ensure that people with MS (PwMS) are included in shared decision-making and disease management. To start this process, a collaborative, open environment between PwMS and healthcare professionals (HCPs) is required so that similarities and disparities in the perception of key areas in patient care and unmet needs can be identified...
November 21, 2017: Multiple Sclerosis and related Disorders
Jennifer Baldwin, Andrew Briggs, Warwick Bagg, Peter Larmer
Osteoarthritis is highly prevalent, disabling and costly to the person and the community. The burden of this chronic condition is predicted to increase dramatically over the coming decades. Healthcare spending on osteoarthritis is unsustainable and action is needed to improve care delivery. At present, there is an over-emphasis on surgical and pharmacological interventions, despite evidence supporting conservative treatments such as exercise, weight loss and education. While clinical guidelines provide recommendations regarding best practice (ie, what to do), they fail to address how to operationalise these recommendations into clinical practice...
December 15, 2017: New Zealand Medical Journal
Habib Tabatabai, Mohammed Aljuboori
Hundreds of people are killed or injured annually in the United States in accidents related to ice formation on roadways and bridge decks. In this paper, a novel embedded sensor system is proposed for the detection of black ice as well as wet, dry, and frozen pavement conditions on roads, runways, and bridges. The proposed sensor works by detecting changes in electrical resistance between two sets of stainless steel poles embedded in the concrete sensor to assess surface and near-surface conditions. A preliminary decision algorithm is developed that utilizes sensor outputs indicating resistance changes and surface temperature...
December 14, 2017: Sensors
Numa Joy Bertola, Maria Papadopoulou, Didier Vernay, Ian F C Smith
Assessing ageing infrastructure is a critical challenge for civil engineers due to the difficulty in the estimation and integration of uncertainties in structural models. Field measurements are increasingly used to improve knowledge of the real behavior of a structure; this activity is called structural identification. Error-domain model falsification (EDMF) is an easy-to-use model-based structural-identification methodology which robustly accommodates systematic uncertainties originating from sources such as boundary conditions, numerical modelling and model fidelity, as well as aleatory uncertainties from sources such as measurement error and material parameter-value estimations...
December 14, 2017: Sensors
Shalv P Madhani, Brian J Frankowski, Sang-Ho Ye, Greg W Burgreen, William R Wagner, Robert Kormos, Jonathan D'Cunha, William J Federspiel
Recent studies show improved outcomes in ambulated lung failure patients. Ambulation still remains a challenge in these patients. This necessitates development of more compact and less cumbersome respiratory support specifically designed to be wearable. The Paracorporeal Ambulatory Assist Lung (PAAL) is being designed for providing ambulatory support in lung failure patients during bridge to transplant or recovery. We previously published in vitro and acute in vivo results of the PAAL. This study further evaluates the PAAL for 5 days...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Ryan A Orizondo, Alexandra G May, Shalv P Madhani, Brian J Frankowski, Greg W Burgreen, Peter D Wearden, William J Federspiel
Acute and chronic respiratory failure are a significant source of pediatric morbidity and mortality. Current respiratory support options used to bridge children to lung recovery or transplantation typically render them bedridden and can worsen long-term patient outcomes. The Pittsburgh Pediatric Ambulatory Lung (P-PAL) is a wearable pediatric blood pump and oxygenator (0.3 m surface area) integrated into a single compact unit that enables patient ambulation. The P-PAL is intended for long-term use and designed to provide up to 90% of respiratory support in children weighing 5-25 kg...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Nikola Dobrilovic, Omar Lateef, Lauren Michalak, Maja Delibasic, Jaishankar Raman
Extracorporeal membrane oxygenation (ECMO) offers an opportunity for patient recovery through complete cardiopulmonary support but is associated with complications that limit duration and overall utility. We examine the role of ECMO as a potential bridge to high-risk cardiac surgery in otherwise inoperable cases. This study reports a retrospective, multi-institution experience examining all patients for whom ECMO was used preoperatively as a bridge to definitive cardiac surgery without exception. A consecutive patient database (December 2011 through August 2017) was utilized...
December 11, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Catherine N Tchanque-Fossuo, Andrew M Wishy, Kaitlyn I M West, David L Dawson, Sara E Dahle, John G Carson
BACKGROUND: Diabetes mellitus is a worldwide pandemic that impacts more than 387 million people, with 29 million individuals affected in the United States alone. Diabetic patients have a 25% lifetime risk of developing a diabetic foot ulcer (DFU). Having a DFU is associated with a risk of recurrence approaching 70%. In addition, 1 in 6 patients with DFU will have a lower-limb amputation, with an associated increase in mortality ranging from 47% to 70%. Therefore, limb salvage is critical in patients with DFU...
January 2018: Advances in Skin & Wound Care
Rachael Hernandez
ISSUE: Medical educators should consider how institutional norms influence medical students' perceptions of implicit bias. Understanding normative structures in medical education can shed light on why this influence is associated with students' resistance to implicit bias. EVIDENCE: Extant research across diverse fields of study uncovers and theorizes layers of norms and normative systems and how they are related to ethical behavior. This review bridges the fields of communication, bioethics, and medical education, constructing an organized foundation and common language by which researchers can build effective educational interventions...
December 14, 2017: Teaching and Learning in Medicine
Andrew R Cook, Michal Valášek, Alison M Funston, Pavel Poliakov, Josef Michl, John R Miller
Optical electron transfer (intervalence) transitions in radical anions of p-carborane oligomers attest to delocalization of electrons between two p-carboranes cages or a p-carborane and a phenyl ring. Oligomers of the twelve vertex p-carborane (C2B10H12) cage, [12], with up to 3 cages were synthesized, as well as p-carboranes with one or two trimethylsilylphenyl groups, [6], attached to the carbon termini. Pulse radiolysis in THF produced radical anions, determined redox potentials by equilibria and measured their absorption spectra...
December 14, 2017: Journal of Physical Chemistry. A
Swarbhanu Sarkar, Nikunj Bhatt, Yeong Su Ha, Phuong Tu Huynh, Nisarg Soni, Woong Hee Lee, Yong Jin Lee, Jung Young Kim, Darpan N Pandya, Gwang Il An, Kyo Chul Lee, Yongmin Chang, Jeongsoo Yoo
Although the importance of bifunctional chelators (BFCs) is well recognized, the chemophysical parameters of chelators that govern the biological behavior of the corresponding bioconjugates have not been clearly elucidated. Here, five BFCs closely related in structure were conjugated with a cyclic RGD peptide and radiolabeled with Cu-64 ions. Various biophysical and chemical properties of the Cu(II) complexes were analyzed with the aim of identifying correlations between individual factors and the biological behavior of the conjugates...
December 14, 2017: Journal of Medicinal Chemistry
A T G Chiu, S L C Pei, C C Y Mak, G K C Leung, M H C Yu, S L Lee, M Vreeburg, R Pfundt, I van der Burgt, T Kleefstra, T M-T Frederic, S Nambot, L Faivre, A-L Bruel, M Rossi, B Isidor, S Küry, B Cogne, T Besnard, M Willems, M R F Reijnders, B H Y Chung
Okur-Chung syndrome is a neurodevelopmental condition attributed to germline CSNK2A1 pathogenic missense variants. We present eight unreported subjects with the above syndrome, who have recognizable dysmorphism, varying degrees of developmental delay and multisystem involvement. Together with six previously reported cases, we present a case series of seven female and seven male subjects, highlighting the recognizable facial features of the syndrome (microcephaly, hypertelorism, epicanthic fold, ptosis, arched eyebrows, low set ears, ear fold abnormality, broad nasal bridge and round face) as well as frequently occurring clinical features including neurodevelopmental delay (93%), gastrointestinal (57%), musculoskeletal (57%) and immunological (43%) abnormalities...
December 14, 2017: Clinical Genetics
Song Zhu, Lei Shi, Shixing Yuan, Xinbiao Xu, Xinliang Zhang
We propose and experimentally demonstrate, to the best of our knowledge, the first all-optical control scheme of ultrahigh-quality (Q)-factor silica microcavities, which can maintain their Q factors over 108 during the tuning process. For silica microcavities, the resonance tunability is very important and is also challenging for many applications. However, almost all previous works on resonance tuning deteriorate the Q factors of silica microcavities at different levels, and evidently these schemes are not suitable for applications in which ultrahigh Q factors are required...
December 15, 2017: Optics Letters
Juan Casado, Paula Mayorga Burrezo, Carlos Franco, Ruben Caballero, Marta Mas, Fernando Langa, Juan T Lopez Navarrete, Concepció Rovira, Jaume Veciana
: A detailed analysis of positive charged species generated on a series of thienylenevinylene (nTV) wires terminally substituted with two perchlorotriphenylmethyl (*PTM) radical acceptors groups, *PTM-nTV-PTM* (n = 2-7), has been carried out. Motivated by the counterintuitively key role played by holes in the nTV bridges on the operating mechanism of electron transfer in their radi-cal-anion mixed-valence derivatives, a wide combination of experimental and theoretical techniques have been used, aiming to get further insights on their structural location...
December 14, 2017: Chemistry: a European Journal
Guangxin Hu, Hui Yang, Qingfeng Hou, Donghong Guo, Gang Chen, Fanghui Liu, Ting Chen, Xuefeng Shi, Yu Su, Jinben Wang
A pH and salt dually responsive emulsion has been designed on the basis of a novel amphiphilic macromolecule. It was found that the water separation of an oil-in-water emulsion reached up to ∼60% after standing for 10 min at low pH. 2-(Diethylamino)ethyl methacrylate (DEA) residues were found to induce the macromolecules to protonate and to be hydrophilic at pH values between 2 and 6, resulting in dewetting from oil droplet surfaces in water. Besides, the macromolecules form aggregates with different structures at the water/oil interface, depending on the pH value or salt concentration of the emulsion system, enabling the system to be demulsified in response to the pH or salt stimulus...
December 14, 2017: Soft Matter
Xi Fan, Nagaraju Narayanam, Meiyan Gao, Lei Zhang, Jian Zhang
In the presence of phosphorous acid and by selecting different bridging ligands, trinuclear Ti3(μ3-O) units have been assembled into coordination cages with topologies such as {Ti6} clusters, {Ti9Cu} tetrahedrons and {Ti18} capsules.
December 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
S T Li, B Braun-Cula, S Hoof, C Limberg
The synthesis of the ligand systems L1 and L2 with two different N3-binding sites linked through a dibenzofuran spacer and their coordination properties towards a variety of CuI precursors are reported. The reaction of L1 with copper halides leads to the formation of a bimetallic species [(L1)(CuICl)2] (1), and metallodimers [((L1)(CuIX)2)2(μ-(Cu)(μ-X)2)] (2: X = Br, 3: X = I) in which two dicopper complexes are bridged by a (μ-(Cu)(μ-X)2)-moiety whereas L2 reacts with copper chloride to afford {[Cu(L2)Cl2]}n (8)...
December 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Junhui Miao, Bin Meng, Jun Liu, Lixiang Wang
Organic molecules with wide absorption spectra exhibit great sunlight harvesting capability and are critically important for solar cell applications. In this manuscript, we develop an A-D-A'-D-A type small molecule acceptor (IID-IC) using isoindigo (IID) as the electron-deficient core unit (A'), thiophene as the electron-rich bridging units (D) and 2-(3-oxo-2,3-dihydroinden-1-ylidene)malononitrile (IC) as the electron-deficient endcapping groups (A). IID-IC shows a wide absorption spectrum with the full width at half maximum (FWHM) of 190 nm, which is almost twice that of a typical A-D-A type molecule acceptor...
December 14, 2017: Chemical Communications: Chem Comm
Timothy S Dunstan, Anupam A K Das, Pierre Starck, Simeon D Stoyanov, Vesselin N Paunov
We demonstrate that capillary suspensions can be formed from hydrophilic calcium carbonate particles suspended in a polar continuous media and connected by capillary bridges formed of minute amounts of an immiscible secondary liquid phase. This was achieved in two different polar continuous phases, water and glycerol, and three different oils, oleic acid, isopropyl myristate, and peppermint oil as a secondary liquid phase. The capillary structuring of the suspension was made possible through local in situ hydrophobization of the calcium carbonate particles dispersed in the polar media by adding very small amounts of oleic acid to the secondary liquid phase...
December 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Horng Hien Wong, Yee Huei Yong, Shazana Shahwan, Laxman Cetty, Janhavi Vaingankar, Charlene Hon, Helen Lee, Christopher Loh, Edimansyah Abdin, Mythily Subramaniam
AIM: This qualitative study explored the perspectives of clients and caregivers on case management provided by the Singapore Early Psychosis Intervention Programme (EPIP), with the intent to understand the salient aspects of case management from their perspective. METHODS: Clients and their caregivers were recruited from the EPIP outpatient clinics. Focus group discussions (FGDs) were conducted at a community centre outside the hospital with 47 clients and 19 caregivers...
December 14, 2017: Early Intervention in Psychiatry
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