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Intratympanic

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https://www.readbyqxmd.com/read/28224644/clinical-effect-of-intratympanic-dexamethasone-injection-in-acute-unilateral-tinnitus-a-prospective-placebo-controlled-multicenter-study
#1
Hyun-Jin Lee, Min-Beom Kim, Shin-Young Yoo, Shi Nae Park, Eui-Cheol Nam, In Seok Moon, Ho-Ki Lee
OBJECTIVE: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. STUDY DESIGN: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. METHODS: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28220492/magnetic-resonance-imaging-of-intratympanic-gadolinium-helps-differentiate-vestibular-migraine-from-m%C3%A3-ni%C3%A3-re-disease
#2
Wenfang Sun, Ping Guo, Tongli Ren, Wuqing Wang
OBJECTIVES/HYPOTHESIS: To study the differential diagnosis of vestibular migraine (VM) and Ménière disease (MD) by using magnetic resonance imaging (MRI) of intratympanic gadolinium. STUDY DESIGN: Prospective cohort study. METHODS: Definite MD patients (n = 30) and definite or probable VM patients (n = 30) were included, and the two groups were age and sex matched. Three-dimensional real inversion recovery (3D-real-IR) MRI was performed 24 hours after bilateral intratympanic gadolinium to assess the presence and degree of endolymphatic hydrops (EH)...
February 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28214024/long-term-outcomes-of-endolymphatic-sac-shunting-with-local-steroids-for-meniere-s-disease
#3
Cameron C Wick, Nauman F Manzoor, Caileigh McKenna, Maroun T Semaan, Cliff A Megerian
OBJECTIVES: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration. STUDY DESIGN: Retrospective case series and patient survey. SETTING: Tertiary university hospital. PATIENTS: Meniere's disease (MD) patients that failed medical therapy and subsequently underwent an endolymphatic sac shunt procedure. All patients had definitive or probable MD and at least 18-months of follow-up...
January 20, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28207624/combined-intratympanic-and-systemic-use-of-steroids-as-a-first-line-treatment-for-sudden-sensorineural-hearing-loss-a-meta-analysis-of-randomized-controlled-trials
#4
Xue Han, Xiao Yin, Xiaodong Du, Changling Sun
OBJECTIVE: To compare the efficacy of combination therapy (combined intratympanic and systemic use of steroids, CT) with systemic steroid therapy (SST) as a primary treatment for sudden sensorineural hearing loss (SSNHL). METHODS: An electronic database search (PubMed, Embase, Cochrane Library, and CNKI databases) was performed. Review Manger 5.3 was used for data synthesis. Data were collected on the following outcomes of interest: the proportion of patients with hearing improvement, changes in pure tone averages (PTA), and speech discrimination score (SDS)...
February 15, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28192380/intratympanic-triamcinolone-and-dexamethasone-in-the-treatment-of-m%C3%A3-ni%C3%A3-re-s-syndrome
#5
Mejd Jumaily, Farhoud Faraji, Anthony A Mikulec
OBJECTIVE: To describe the safety and potential efficacy of intratympanic administration of triamcinolone (40 mg/mL) in the treatment of unilateral Ménière's syndrome. STUDY DESIGN: Single-institution retrospective analysis. SETTING: Tertiary referral neurotology clinic. PATIENTS: Eighteen patients diagnosed with unilateral Ménière's syndrome with vertigo refractory to medical management. INTERVENTION(S): Intratympanic injection of triamcinolone or dexamethasone...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28125313/effects-of-early-intratympanic-steroid-injection-in-patients-with-acoustic-trauma-caused-by-gunshot-noise
#6
Young-Soo Chang, Kang Hyun Bang, Byoungseo Jeong, Gang-Gyu Lee
CONCLUSION: This study evaluated the efficacy of concurrent administration of ITSI and systemic steroids in delayed treatment of NIHL after gunshot noise exposure. The results showed additional hearing benefits with administration of ITSI. Further evaluation is warranted to confirm this efficacy. OBJECTIVE: This investigation evaluated the effects of early administration of an intratympanic steroid injection (ITSI) in combination with systemic steroids treatment in patients with acoustic trauma caused by gunshot noise...
January 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28072657/assessment-of-cochlea-endolymphatic-hydrops-using-3-d-flair-and-3-d-real-ir-sequence-in-guinea-pigs-via-3t-mri-after-intratympanic-gadolinium-a-histopathological-comparison
#7
Feng Wang, Huiying Lyu, Menglong Zhao, Yan Sha, Fang Zhang, Yushu Cheng, Wenhu Huang, Wenlin Tang, Youzhou Xie, Ping Lu
OBJECTIVE: We assessed whether the three-dimensional fluid-attenuated inversion-recovery (3-D FLAIR) and three-dimensional inversion-recovery with real reconstruction (3-D real IR) sequences can be used to detect cochlea endolymphatic hydrops (EHs) in guinea pigs using 3 Tesla magnetic resonance imaging (3T MRI). The results of 3-D real IR imaging were compared with histopathological outcomes. MATERIALS AND METHODS: Fourteen healthy men and women albino guinea pigs were used in this study...
January 9, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28050646/gentamicin-applied-to-the-oval-window-suppresses-vestibular-function-in-guinea-pigs
#8
E B King, R K Shepherd, D J Brown, J B Fallon
Intratympanic gentamicin therapy is widely used clinically to treat the debilitating symptoms of Ménière's disease. Cochleotoxicity is an undesirable potential side effect of the treatment and the risk of hearing loss increases proportionately with gentamicin concentration in the cochlea. It has recently been shown that gentamicin is readily absorbed through the oval window in guinea pigs. The present study uses quantitative functional measures of vestibular and cochlea function to investigate the efficacy of treating the vestibule by applying a small volume of gentamicin onto the stapes footplate in guinea pigs...
January 3, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28033296/intratympanic-steroids-injection-is-effective-for-the-treatment-of-drop-attacks-with-m%C3%A3-ni%C3%A3-re-s-disease-and-delayed-endolymphatic-hydrops-a-retrospective-study
#9
Bo Liu, Yangming Leng, Renhong Zhou, Jingjing Liu, Dongdong Liu, Su-Lin Zhang, Wei-Jia Kong
Drop attack (DA) associated with Ménière's disease (MD) and delayed endolymphatic hydrops (DEH) is not common and may cause life-threatening clinical problems. The intratympanic dexamethasone (ITD) is one of primary treatments for MD or DEH. Our study investigated the effect of ITD on the DA associated with endolymphatic hydrops (EH).We retrospectively reviewed 10 patients with MD- and DEH-associated DA between January 2009 and December 2013 in Outpatient Department of Otolaryngology, Union Hospital, Wuhan, China...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28017456/diagnosis-of-endolymphatic-hydrops-by-means-of-3t-magnetic-resonance-imaging-after-intratympanic-administration-of-gadolinium
#10
M Tuñón Gómez, D R Lobo Duro, B Brea Álvarez, J R García-Berrocal
OBJECTIVE: To detect and graduate endolymphatic hydrops or endolymphatic space dilations in patients with suspected Meniere's disease or immune-mediated inner ear disease by magnetic resonance imaging. MATERIAL AND METHODS: A prospective study was performed including all the patients with clinical suspicion of Meniere's disease or immune-mediated inner ear disease treated at the Otolaryngology department during a one year period. In all cases, magnetic resonance imaging (MRI) was performed in a 3T scanner...
December 22, 2016: Radiología
https://www.readbyqxmd.com/read/27995828/single-dose-intratympanic-mesna-application-inhibits-propylene-glycol-induced-cholesteatoma-formation
#11
O Ismi, Y Y Karabulut, K K Bal, Y Vayisoglu, M Unal
OBJECTIVE: Mesna (i.e. sodium 2-mercaptoethanesulfonate; C2H5NaO3S2) has been used in otological surgery such as cholesteatoma dissection and tympanic membrane lateralisation in atelectatic ears. However, this study aimed to investigate its effect on cholesteatoma formation. METHODS: A total of 20 Wistar rats were divided into two groups of 10 animals. The right and left ears of control animals were treated with saline (saline control group; n = 10 ears) and propylene glycol plus saline (propylene glycol control group; n = 10 ears), respectively...
December 20, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27964845/intratympanic-steroid-injection-and-hyperbaric-oxygen-therapy-for-the-treatment-of-refractory-sudden-hearing-loss
#12
Filiz Gülüstan, Zahide Mine Yazıcı, Wesam M E Alakhras, Omer Erdur, Harun Acipayam, Levent Kufeciler, Fatma Tulin Kayhan
INTRODUCTION: Controversy surrounds the use of salvage therapies to treat sudden sensorineural hearing loss (SSNHL), with no consensus on recommendations. While several studies have demonstrated the effectiveness of intratympanic administration of steroids (ITS) and hyperbaric oxygen (HBO) treatment, few have compared the efficacy of ITS and HBO therapy in patients with refractory SSNHL. OBJECTIVE: We evaluated the efficiency of ITS and HBO therapy in patients with refractory SSNHL...
November 22, 2016: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27933352/intracochlear-drug-delivery-in%C3%A2-combination-with-cochlear-implants-current-aspects
#13
S K Plontke, G Götze, T Rahne, A Liebau
Local drug application to the inner ear offers a number of advantages over systemic delivery. Local drug therapy currently encompasses extracochlear administration (i. e., through intratympanic injection), intracochlear administration (particularly for gene and stem cell therapy), as well as various combinations with auditory neurosensory prostheses, either evaluated in preclinical or clinical studies, or off-label. To improve rehabilitation with cochlear implants (CI), one focus is the development of drug-releasing electrode carriers, e...
January 2017: HNO
https://www.readbyqxmd.com/read/27921520/a-comparison-between-systemic-and-intratympanic-steroid-therapies-as-initial-therapy-for-idiopathic-sudden-sensorineural-hearing-loss-a-meta-analysis
#14
Qingfen Qiang, Xuewen Wu, Tao Yang, Chunguang Yang, Hong Sun
CONCLUSIONS: Intratympanic steroid (ITS) treatment groups exhibited better outcomes in PTA improvement and recovery rate than systemic steroid therapy (SST) groups. Whether initial hearing loss severity would influence the PTA improvement and recovery rate still requires further research. OBJECTIVE: This article was aimed at evaluating whether intratympanic steroid (ITS) treatment would provide benefits over systemic steroid therapy (SST) as initial therapy in patients with idiopathic sudden sensorineural hearing loss (ISSHL)...
December 6, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27898607/effects-of-intratympanic-dexamethasone-on-high-dose-radiation-ototoxicity-in-vivo
#15
Christine T Dinh, Si Chen, John Dinh, Stefania Goncalves, Esperanza Bas, Kyle Padgett, Perry Johnson, Nagy Elsayyad, Fred Telischi, Thomas Van De Water
BACKGROUND: Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. HYPOTHESIS: Intratympanic (IT) dexamethasone (DXM), a synthetic steroid, protects against radiation-induced auditory hair cell (HC) and hearing losses in rats in vivo. METHODS: Seven rats received radiation (12 Gy) to both cochleae...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27897129/a-pilot-study-using-intratympanic-methylprednisolone-for-treatment-of-persistent-posterior-canal-benign-paroxysmal-positional-vertigo
#16
Paz Pérez, Virginia Franco, Manuel Oliva, José A López Escámez
OBJECTIVE: To assess the effect of intratympanic methylprednisolone (ITMP) in posterior canal benign paroxysmal positional vertigo (BPPV) that fails treatment involving repositioning maneuver in a case series. MATERIALS AND METHODS: Nine patients with persistent posterior canal BPPV after 6 or more repositioning maneuvers were treated by ITMP (two weekly doses of 0.3-0.4 mL at 40 mg/mL) before repeating the repositioning procedures. RESULTS: Following ITMP treatment, 7 out of 9 patients were relieved of their symptoms and did not exhibit positional nystagmus after 1 or 2 repositioning maneuvers...
November 28, 2016: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/27894374/autologous-intratympanic-blood-patch-for-presumed-perilymphatic-fistulas
#17
P K Foster
OBJECTIVE: To assess an alternative to bed rest and surgery for suspected perilymphatic fistulas using intratympanic blood injections. METHOD: A review was conducted of patients' history, physical and audiometric data, before and after treatment by intratympanic blood injections performed from 2009 to 2015. RESULTS: Twelve ears were identified, with trauma associated with air travel, water sports or nose blowing. Ten of these cases had hearing loss, six had vestibular symptoms...
December 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27865535/intratympanic-methylprednisolone-versus-gentamicin-in-patients-with-unilateral-m%C3%A3-ni%C3%A3-re-s-disease-a-randomised-double-blind-comparative-effectiveness-trial
#18
Mitesh Patel, Kiran Agarwal, Qadeer Arshad, Mohamed Hariri, Peter Rea, Barry M Seemungal, John F Golding, Jonny P Harcourt, Adolfo M Bronstein
BACKGROUND: Ménière's disease is characterised by severe vertigo attacks and hearing loss. Intratympanic gentamicin, the standard treatment for refractory Ménière's disease, reduces vertigo, but damages vestibular function and can worsen hearing. We aimed to assess whether intratympanic administration of the corticosteroid methylprednisolone reduces vertigo compared with gentamicin. METHODS: In this double-blind comparative effectiveness trial, patients aged 18-70 years with refractory unilateral Ménière's disease were enrolled at Charing Cross Hospital (London, UK) and Leicester Royal Infirmary (Leicester, UK)...
December 3, 2016: Lancet
https://www.readbyqxmd.com/read/27861924/intratympanic-dexamethasone-in-sudden-sensorineural-hearing-loss-a-systematic-review-and-meta-analysis
#19
REVIEW
Nagi G El Sabbagh, Maida J Sewitch, Aren Bezdjian, Sam J Daniel
OBJECTIVE: Systemic dexamethasone has demonstrated conclusive benefits in reversing sudden sensorineural hearing loss (SSNHL) despite considerable number of potential side effects. In contrast, the intratympanic route of steroid administration averts several possible complications. This study aims to examine the literature to delineate the efficacy and side effect of intratympanic dexamethasone (ITD) injection for the treatment of SSNHL. DATA SOURCE: Cochrane, Embase, and MEDLINE electronic databases from January 1950 to August 2014, with an update performed on November 10, 2014...
November 15, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27821219/effects-of-two-different-local-anaesthetic-methods-vs-no-anaesthesia-on-pain-scores-for-intratympanic-injections
#20
COMPARATIVE STUDY
N Ata, O Erdur, M H Görgülü, E Yilmaz
OBJECTIVE: This study compared the pain associated with the intratympanic injection combined with various local anaesthetics vs without anaesthesia. METHODS: The study included 40 patients (aged 18-78 years) who received intratympanic steroid injections for sudden idiopathic hearing loss or tinnitus. Each patient underwent all three injection methods at one-week intervals. Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes...
December 2016: Journal of Laryngology and Otology
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