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Intratympanic

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https://www.readbyqxmd.com/read/28437363/intratympanic-dexamethasone-in-the-treatment-of-m%C3%A3-ni%C3%A3-re-s-disease-a-comparison-of-two-techniques
#1
Jason A Beyea, Ryan S Instrum, Sumit K Agrawal, Lorne S Parnes
OBJECTIVE: To assess the efficacy and safety of two different intratympanic dexamethasone (IT Dex) injection protocols for intractable unilateral Ménière's disease. STUDY DESIGN: Prospective case series. SETTING: Tertiary neurotology clinic. PATIENTS: One hundred six consecutive adult patients with definite unilateral Ménière's disease who had failed medical management were studied for an average of 1,061 days. None had previous oral steroid, IT steroid, or ablative treatment...
April 21, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28434389/evaluation-of-the-protective-effect-of-botulinum-toxin-type-a-injection-on-otitis-media-with-effusion
#2
Ömer Faruk Çalım, Yavuz Selim Yıldırım, Remzi Doğan, Selhattin Tuğrul, Özge Gedik, Orhan Özturan
OBJECTIVE: This study makes an analysis of the effect of Botulinum toxin type A on otitis media with effusion in rats. METHOD: As part of the study, 24 male Wistar Albino rats were divided into three groups: Group 1: Botulinum toxin Type A and Histamıne (intratympanic 0.2 ml = 20 unit BTA); Group 2: Saline and Histamine (intratympanic 0.2 ml 0.9%); Group 3: Histamine (intratympanic 0.2 ml). Histamine (intratympanic 0.2 ml) was administered into the right ear for all groups...
April 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28424655/sustained-and-transient-vestibular-systems-a-physiological-basis-for-interpreting-vestibular-function
#3
REVIEW
Ian S Curthoys, Hamish G MacDougall, Pierre-Paul Vidal, Catherine de Waele
Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological differentiation. A specialized band of receptors called the striola consists of mainly type I receptors whose hair bundles are weakly tethered to the overlying otolithic membrane. The afferent neurons, which form calyx synapses on type I striolar receptors, have irregular resting discharge and have low thresholds to high frequency (e...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28417102/prognostic-factors-for-recovery-from-sudden-sensorineural-hearing-loss-a-retrospective-study
#4
Woo Seok Kang, Chan Joo Yang, Myungjoo Shim, Chan Il Song, Tae Su Kim, Hyun Woo Lim, Joong Ho Ahn, Hong Ju Park, Jong Woo Chung
BACKGROUND AND OBJECTIVES: This study aimed to investigate prognostic factors in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). SUBJECTS AND METHODS: From January 2007 to December 2011, a retrospective chart review identified 494 consecutive patients with ISSNHL. Demographic, audiometric, and clinical data were analyzed using a logistic regression test. RESULTS: Hearing recovery from ISSNHL was significantly associated with factors such as age, duration from onset of symptoms to commencement of treatment, severity of the initial pure tone threshold, and the treatment method...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28413076/detection-of-endolymphatic-hydrops-using-traditional-mr-imaging-sequences
#5
John H Keller, Barry E Hirsch, Ryan S Marovich, Barton F Branstetter
PURPOSE: The purpose of this study was to determine whether Meniere's disease (MD) produces endolymphatic cavity size changes that are detectable using unenhanced high-resolution T2-weighted MRI. MATERIALS & METHODS: This retrospective case-control study included patients with documented MD who had a high-resolution T2-weighted or steady-state free procession MRI of the temporal bones within one month of diagnosis, between 2002 and 2015. Patients were compared to age- and sex- matched controls...
April 6, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28384627/simultaneous-versus-sequential-intratympanic-steroid-treatment-for-severe-to-profound-sudden-sensorineural-hearing-loss
#6
Myung Hoon Yoo, Won Sub Lim, Joo Hyun Park, Joong Keun Kwon, Tae-Hoon Lee, Yong-Hwi An, Young-Jin Kim, Jong Yang Kim, Hyun Woo Lim, Hong Ju Park
OBJECTIVES: Severe-to-profound sudden sensorineural hearing loss (SSNHL) has a poor prognosis. We aimed to compare the efficacy of simultaneous and sequential oral and intratympanic steroids for this condition. METHODS: Fifty patients with severe-to-profound SSNHL (>70 dB HL) were included from 7 centers. The simultaneous group (27 patients) received oral and intratympanic steroid injections for 2 weeks. The sequential group (23 patients) was treated with oral steroids for 2 weeks and intratympanic steroids for the subsequent 2 weeks...
April 7, 2017: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28376942/voice-in-t1b-glottic-tumours-intratympanic-steroids-for-salvage-in-sensorineural-hearing-loss-intranasal-steroids-for-obstructive-sleep-apnoea-and-a-new-procedure-for-post-radiation-nasal-stenosis
#7
Musheer Hussain, Edward Fisher, Robin Youngs, Jonathan Fishman
No abstract text is available yet for this article.
May 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28362376/a-comparative-study-of-drug-delivery-methods-targeted-to-the-mouse-inner-ear-bullostomy-versus-transtympanic-injection
#8
Silvia Murillo-Cuesta, Néstor Vallecillo, Rafael Cediel, Adelaida M Celaya, Luis Lassaletta, Isabel Varela-Nieto, Julio Contreras
We present two minimally invasive microsurgical techniques in rodents for specific drug delivery into the middle ear so that it may reach the inner ear. The first procedure consists of perforation of the tympanic bulla, termed bullostomy; the second one is a transtympanic injection. Both emulate human clinical intratympanic procedures. Chitosan-glycerophosphate (CGP) and Ringer´s Lactate buffer (RL) were used as biocompatible vehicles for local drug delivery. CGP is a nontoxic biodegradable polymer widely used in pharmaceutical applications...
March 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28359220/the-effect-of-initial-treatment-on-hearing-prognosis-in-idiopathic-sudden-sensorineural-hearing-loss-a-nationwide-survey-in-japan
#9
Masahiro Okada, Naohito Hato, Shin-Ya Nishio, Ryosuke Kitoh, Kaoru Ogawa, Sho Kanzaki, Michihiko Sone, Satoshi Fukuda, Akira Hara, Tetsuo Ikezono, Kotaro Ishikawa, Satoshi Iwasaki, Kimitaka Kaga, Seiji Kakehata, Atsushi Matsubara, Tatsuo Matsunaga, Takaaki Murata, Yasushi Naito, Takashi Nakagawa, Kazunori Nishizaki, Yoshihiro Noguchi, Hajime Sano, Hiroaki Sato, Mikio Suzuki, Hideo Shojaku, Haruo Takahashi, Hidehiko Takeda, Tetsuya Tono, Hiroshi Yamashita, Tatsuya Yamasoba, Shin-Ichi Usami
OBJECTIVE: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. METHODS: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids...
March 31, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28349227/effects-of-bilateral-vestibular-deafferentation-in-rat-on-hippocampal-theta-response-to-somatosensory-stimulation-acetylcholine-release-and-cholinergic-neurons-in-the-pedunculopontine-tegmental-nucleus
#10
Phillip Aitken, Yiwen Zheng, Paul F Smith
Vestibular dysfunction has been shown to cause spatial memory impairment. Neurophysiological studies indicate that bilateral vestibular loss (BVL), in particular, is associated with an impairment of the response of hippocampal place cells and theta rhythm. However, the specific neural pathways through which vestibular information reaches the hippocampus are yet to be fully elucidated. The aim of the present study was to further investigate the hypothesised 'theta-generating pathway' from the brainstem vestibular nucleus to the hippocampus...
March 27, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28306710/are-intratympanic-corticosteroids-effective-for-m%C3%A3-ni%C3%A3-re%C3%A2-s-disease
#11
Ángela Chuang-Chuang, María A Baeza
Ménière’s disease affects the inner ear and its main symptoms are vertigo, hearing loss and fluctuating aural symptoms. Nowadays, there are many therapeutic alternatives, being the use of intratympanic corticosteroids one that has become popular. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple databases. We identified four systematic reviews including 15 studies overall, of which seven were randomized trials. We extracted data and generated a summary of findings table using the GRADE approach...
March 13, 2017: Medwave
https://www.readbyqxmd.com/read/28304075/steroid-intracochlear-distribution-differs-by-administration-method-systemic-versus-intratympanic-injection
#12
Jong Joo Lee, Jeong Hun Jang, Oak-Sung Choo, Hye Jin Lim, Yun-Hoon Choung
OBJECTIVE: Steroids have been widely used to treat inner-ear diseases such as sudden sensorineural hearing loss, tinnitus, and Meniere's disease. They can be given via either systemic or intratympanic (IT) injection. The purpose of the present study was to explore differences in intracochlear steroid distribution by the administration method employed (systemic vs. IT injection). STUDY DESIGN: Animal study. METHODS: Twenty-three Sprague-Dawley rats were given fluorescein isothiocyanate-labeled dexamethasone (FITC-DEX) three times (on successive days) via intraperitoneal (IP) or IT injection...
March 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28292626/intratympanal-gentamicin-in-meniere-s-disease-effects-on-individual-semicircular-canals
#13
Béla Büki, Heinz Jünger
OBJECTIVE: In this retrospective study the aim of the authors was to examine the effect of gentamicin on the individual semicircular canals after low dose, single injection intratympanal gentamicin therapy in Meniere's disease. METHODS: Data of 32 patients treated between 2011 and 2015 were collected. The high frequency, high acceleration vestibuloocular reflex (VOR) gain was measured in the individual semicircular canals using video head impulse test immediately before the first intratympanal gentamicin instillation and approximately two months later...
March 11, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28290919/intratympanic-methylprednisolone-perfusion-as-a-salvage-treatment-for-profound-idiopathic-sudden-sensorineural-hearing-loss
#14
Y Dai, L Lu, J Hou, X Yang, H Li, Y Yang, W She
OBJECTIVE: This study aimed to examine the effectiveness of intratympanic methylprednisolone perfusion as salvage treatment for profound idiopathic sudden sensorineural hearing loss. METHODS: A retrospective clinical study of 97 patients with unilateral profound idiopathic sudden sensorineural hearing loss was performed. In all, 83 patients who received salvage intratympanic methylprednisolone perfusion plus conventional treatment (except for steroids) as the second-line therapy were assigned to the study group, while 14 patients who received conventional treatment alone were assigned to the comparison group...
May 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28224644/clinical-effect-of-intratympanic-dexamethasone-injection-in-acute-unilateral-tinnitus-a-prospective-placebo-controlled-multicenter-study
#15
Hyun-Jin Lee, Min-Beom Kim, Shin-Young Yoo, Shi Nae Park, Eui-Cheol Nam, In Seok Moon, Ho-Ki Lee
OBJECTIVE: The purpose of this study was to investigate the effectiveness of intratympanic dexamethasone injection (ITDI) in acute tinnitus of presumed cochlear origin. STUDY DESIGN: A prospective, randomized, placebo-controlled, double-blinded, multicenter study. METHODS: Between August 2013 and December 2015, 54 patients with unilateral tinnitus were enrolled at four different centers. Patients were assigned either to an ITDI (n = 27) or an intratympanic normal saline injection (ITNI; n = 27) group through block randomization...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28220492/magnetic-resonance-imaging-of-intratympanic-gadolinium-helps-differentiate-vestibular-migraine-from-m%C3%A3-ni%C3%A3-re-disease
#16
Wenfang Sun, Ping Guo, Tongli Ren, Wuqing Wang
OBJECTIVES/HYPOTHESIS: To study the differential diagnosis of vestibular migraine (VM) and Ménière disease (MD) by using magnetic resonance imaging (MRI) of intratympanic gadolinium. STUDY DESIGN: Prospective cohort study. METHODS: Definite MD patients (n = 30) and definite or probable VM patients (n = 30) were included, and the two groups were age and sex matched. Three-dimensional real inversion recovery (3D-real-IR) MRI was performed 24 hours after bilateral intratympanic gadolinium to assess the presence and degree of endolymphatic hydrops (EH)...
February 21, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28214024/long-term-outcomes-of-endolymphatic-sac-shunting-with-local-steroids-for-meniere-s-disease
#17
Cameron C Wick, Nauman F Manzoor, Caileigh McKenna, Maroun T Semaan, Cliff A Megerian
OBJECTIVES: To evaluate the long-term efficacy of endolymphatic sac shunt techniques with and without local steroid administration. STUDY DESIGN: Retrospective case series and patient survey. SETTING: Tertiary university hospital. PATIENTS: Meniere's disease (MD) patients that failed medical therapy and subsequently underwent an endolymphatic sac shunt procedure. All patients had definitive or probable MD and at least 18-months of follow-up...
January 20, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28207624/combined-intratympanic-and-systemic-use-of-steroids-as-a-first-line-treatment-for-sudden-sensorineural-hearing-loss-a-meta-analysis-of-randomized-controlled-trials
#18
Xue Han, Xiao Yin, Xiaodong Du, Changling Sun
OBJECTIVE: To compare the efficacy of combination therapy (combined intratympanic and systemic use of steroids, CT) with systemic steroid therapy (SST) as a primary treatment for sudden sensorineural hearing loss (SSNHL). METHODS: An electronic database search (PubMed, Embase, Cochrane Library, and CNKI databases) was performed. Review Manger 5.3 was used for data synthesis. Data were collected on the following outcomes of interest: the proportion of patients with hearing improvement, changes in pure tone averages (PTA), and speech discrimination score (SDS)...
April 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28192380/intratympanic-triamcinolone-and-dexamethasone-in-the-treatment-of-m%C3%A3-ni%C3%A3-re-s-syndrome
#19
Mejd Jumaily, Farhoud Faraji, Anthony A Mikulec
OBJECTIVE: To describe the safety and potential efficacy of intratympanic administration of triamcinolone (40 mg/mL) in the treatment of unilateral Ménière's syndrome. STUDY DESIGN: Single-institution retrospective analysis. SETTING: Tertiary referral neurotology clinic. PATIENTS: Eighteen patients diagnosed with unilateral Ménière's syndrome with vertigo refractory to medical management. INTERVENTION(S): Intratympanic injection of triamcinolone or dexamethasone...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28125313/effects-of-early-intratympanic-steroid-injection-in-patients-with-acoustic-trauma-caused-by-gunshot-noise
#20
Young-Soo Chang, Kang Hyun Bang, Byoungseo Jeong, Gang-Gyu Lee
CONCLUSION: This study evaluated the efficacy of concurrent administration of ITSI and systemic steroids in delayed treatment of NIHL after gunshot noise exposure. The results showed additional hearing benefits with administration of ITSI. Further evaluation is warranted to confirm this efficacy. OBJECTIVE: This investigation evaluated the effects of early administration of an intratympanic steroid injection (ITSI) in combination with systemic steroids treatment in patients with acoustic trauma caused by gunshot noise...
January 26, 2017: Acta Oto-laryngologica
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