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Intratympanic

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https://www.readbyqxmd.com/read/29455211/intratympanic-injections-of-dexamethasone-in-delayed-endolymphatic-hydrops-a-prospective-clinical-study
#1
Ashraf Elsayed Morgan, Elshahat Ibrahem Ismail, Bassem Ashraf
OBJECTIVE: This study was designed to evaluate the effectiveness of intratympanic dexamethazone (ITD) for the treatment of ipsilateral delayed endolymphatic hydrops (DEH). METHODS: Forty-one patients were diagnosed with ipsilateral DEH. Only 37 patients completed this study. Patients were randomly divided into 2 groups. Group A (n = 16) received oral medication, and group B (n = 21) received ITD once weekly for 4 consecutive weeks. RESULTS: In group A, 6 patients showed improvement in their vertigo...
February 16, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29436794/the-follow-up-role-of-the-vestibular-evoked-myogenic-potential-test-in-meniere-s-disease
#2
Nasrin Yazdani, Farzaneh Nejadian, Nima Rezazadeh, Reza Hoseinabadi, Ebrahim Karimi, Reza Gharibi, Sasan Dabiri
Despite some proposed roles for the diagnostic impact of the cervical vestibular evoked myogenic potential test in the patients with Meniere's disease, the role of this test as an objective instrument in following up the patients with Meniere's disease who underwent. Intratympanic steroid injection is not cleared. In a prospective study, thirty-one adult patients with definite one-sided Meniere's disease with vertigo as main complaint refractory to medical treatments for three months, were selected. Patients underwent three times of intratympanic dexamethasone injection with one-week intervals...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29411622/comparison-of-2-and-4-intratympanic-steroid-injections-in-the-treatment-of-idiopathic-sudden-sensorineural-hearing-loss
#3
Hideaki Suzuki, Tetsuro Wakasugi, Takuro Kitamura, Hiroki Koizumi, Ba Hung Do, Toyoaki Ohbuchi
OBJECTIVE: We studied the effect of intratympanic steroid administration with different total injection times on hearing outcomes in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). METHODS: The subjects were 191 consecutive patients (192 ears) with ISSNHL (hearing level ≥40 dB, interval between onset and treatment ≤30 days). They received systemic prednisolone (100 mg followed by tapered doses) combined with intratympanic injection of dexamethasone (4 mg/ml)...
February 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29402608/instrumental-head-impulse-test-changes-after-intratympanic-gentamicin-for-unilateral-definite-m%C3%A3-ni%C3%A3-re-s-disease-a-systematic-review-and-meta-analysis
#4
Pedro Santos Marques, Claudia Camila Dias, Nicolas Perez-Fernandez, Jorge Spratley
OBJECTIVE: To estimate how much could intratympanic gentamicin (ITG) interfere with the vestibular-ocular reflex (VOR) parameters on instrumental head impulse test (HIT), either with scleral search coil or video head impulse test and, eventually, foresee the control of vertigo crisis in unilateral intractable Ménière's disease (MD). METHODS: A literature search was conducted in PubMed, Scopus, Web of Science and Cochrane search engines. The search terms used were "vestibular ocular reflex", "head impulse test", "gentamicin," and "Meniere's disease"...
February 2, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29400686/prehab-vs-rehab-presurgical-treatment-in-vestibular-schwannoma-surgery-enhances-recovery-of-postural-control-better-than-postoperative-rehabilitation-retrospective-case-series
#5
Fredrik Tjernström, Per-Anders Fransson, Babar Kahlon, Mikael Karlberg, Sven Lindberg, Peter Siesjö, Måns Magnusson
OBJECT: To evaluate post-surgical postural stability when treating patients with remaining vestibular function with intratympanic gentamicin (PREHAB) prior to schwannoma surgery. METHOD: 44 consecutive patients with some form remaining vestibular function scheduled for vestibular schwannoma surgery. 20 were medically deafferented with intratympanic gentamicin before surgery and 24 were not. Both groups were of the same age, had the same tumor size, same type of surgery, and same perioperative sensory rehabilitation (training exercises), and no surgical complications...
2018: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29395279/safety-and-efficacy-of-intratympanic-ciprofloxacin-otic-suspension-post-tubes-in-a-real-world-pediatric-population
#6
Joseph E Dohar, Debra Don, Jeffrey Koempel, Chung H Lu, Dean Hakanson, Kenny H Chan
PURPOSE: Otorrhea frequently follows tympanostomy tube (TT) placement. We evaluated otorrhea following single 6mg OTO-201 (OTIPRIO®, ciprofloxacin otic suspension 6%) intraoperative injection into each middle ear in a variety of effusion types and concurrent procedures in children undergoing TT placement. SECONDARY OBJECTIVE: Efficacy based on Medicaid status and safety. BASIC PROCEDURES: In this prospective, 8-week, multicenter, open-label study, 501 patients were enrolled: mean age 2...
December 21, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29392065/possible-ototoxic-effects-of-topical-rifamycin-application-an-electrophysiological-and-ultrastructural-study
#7
Cihan Abaylı, Yusuf Kul, Muhsin Koten, Ahmet Rıfat Karasalihoğlu, Abdullah Taş, Recep Yağız, Erdoğan Bulut
Objective: This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations. Methods: Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0...
September 2017: Turkish Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29390288/intratympanic-glucocorticosteroid-therapy-for-idiopathic-sudden-hearing-loss-meta-analysis-of-randomized-controlled-trials
#8
Dan Lai, Fei Zhao, Nasim Jalal, Yun Zheng
BACKGROUND AND OBJECTIVE: Glucocorticoids are the standard treatment for idiopathic sudden sensorineural hearing loss (ISSNHL), but whether intratympanic or systemic therapy is superior remains controversial. Previous meta-analyses of this question have omitted key clinical trials or included observational studies. METHODS: English-language randomized controlled trials in OvidSP, PubMed, Embase, CINAHL, and the Cochrane Library comparing intratympanic versus systemic glucocorticoid therapy for ISSNHL were meta-analyzed using RevMan 5...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383315/methylprednisolone-versus-dexamethasone-for-control-of-vertigo-in-patients-with-definite-meniere-s-disease
#9
Elham Masoumi, Sasan Dabiri, Mohammad Taghi Khorsandi Ashtiani, Reza Erfanian, Saeed Sohrabpour, Nasrin Yazdani, Alireza Safaee, Mohammadreza Firouzifar
Introduction: Definite Meniere's disease is associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo. Materials and Methods: In this clinical study, 69 patients with definite Meniere's disease, referred to the tertiary otolaryngology center, were randomly assigned to two groups: 36 patients were treated with intratympanic dexamethasone (4mg/dl) and 33 patients were treated with i ntratympanic methylprednisolone (40mg/dl)...
November 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29339961/skew-deviation-and-partial-ocular-tilt-reaction-due-to-intratympanic-gentamicin-injection-with-review-of-the-literature
#10
Samuel M Dresner, Nathan H Kung, Joel R Palko, Jonathan L McJunkin, Joel A Goebel, Gregory P Van Stavern
Skew deviation is a rare side effect of intratympanic gentamicin injection for intractable Meniere's disease. When the skew deviation is accompanied by pathologic head tilt and ocular torsion, the result is an ocular tilt reaction (OTR). The authors report the case of a 56-year-old man with refractory Meniere's disease who developed binocular vertical diplopia following intratympanic gentamicin injection and was found to have skew deviation and a partial ocular tilt reaction. The authors also review the reported cases of skew deviation following intratympanic gentamicin and confirm this phenomenon, which has only rarely been reported in the literature...
October 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29338942/international-consensus-icon-on-treatment-of-m%C3%A3-ni%C3%A3-re-s-disease
#11
J Nevoux, M Barbara, J Dornhoffer, W Gibson, T Kitahara, V Darrouzet
OBJECTIVE: To present the international consensus for recommendations for Ménière's disease (MD) treatment. METHODS: Based on a literature review and report of 4 experts from 4 continents, the recommendations have been presented during the 21st IFOS congress in Paris, in June 2017 and are presented in this work. RESULTS: The recommendation is to change the lifestyle, to use the vestibular rehabilitation in the intercritic period and to propose psychotherapy...
January 12, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29287037/correlations-between-the-degree-of-endolymphatic-hydrops-and-symptoms-and-audiological-test-results-in-patients-with-meni%C3%A3-re-s-disease-a-reevaluation
#12
Shiyin Yang, Huaming Zhu, Bijun Zhu, Hui Wang, Zhengnong Chen, Yaqin Wu, Bin Chen, Haibo Shi, Yuehua Li, Jing Zou, Shankai Yin
OBJECTIVE: This study was performed to reevaluate the diagnostic significance of clinically well-accepted audiological tests in indicating endolymphatic hydrops (EH) in Menière's disease (MD). STUDY DESIGN: Retrospective case review. SETTINGS: Hospital. PATIENTS: Fifty patients (52 affected ears) diagnosed with MD were enrolled. INTERVENTION: Diagnostic. MAIN OUTCOME MEASURE: To analyze the correlations between endolymphatic hydrops and results of audiological test including the pure-tone audiometry threshold, suprathreshold function tests, electrocochleogram, and glycerol test...
December 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29279722/current-diagnostic-procedures-for-diagnosing-vertigo-and-dizziness
#13
REVIEW
Leif Erik Walther
Vertigo is a multisensory syndrome that otolaryngologists are confronted with every day. With regard to the complex functions of the sense of orientation, vertigo is considered today as a disorder of the sense of direction, a disturbed spatial perception of the body. Beside the frequent classical syndromes for which vertigo is the leading symptom (e.g. positional vertigo, vestibular neuritis, Menière's disease), vertigo may occur as main or accompanying symptom of a multitude of ENT-related diseases involving the inner ear...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29277248/communication-pathways-to-and-from-the-inner-ear-and-their-contributions-to-drug-delivery
#14
REVIEW
Alec N Salt, Keiko Hirose
The environment of the inner ear is highly regulated in a manner that some solutes are permitted to enter while others are excluded or transported out. Drug therapies targeting the sensory and supporting cells of the auditory and vestibular systems require the agent to gain entry to the fluid spaces of the inner ear, perilymph or endolymph, which surround the sensory organs. Access to the inner ear fluids from the vasculature is limited by the blood-labyrinth barriers, which include the blood-perilymph and blood-strial barriers...
December 19, 2017: Hearing Research
https://www.readbyqxmd.com/read/29272985/the-expression-of-thymic-stromal-lymphopoietin-in-patients-and-animal-models-with-eosinophilic-otitis-media
#15
Tomoya Miura, Atsushi Matsubara, Naomi Kudo, Ryutaro Hara, Junko Takahata, Akira Sasaki
OBJECTIVE: In the present study, we aimed to clarify the expression of thymic stromal lymphopoietin (TSLP), a key trigger of Th2-type allergic disease, in the middle ear mucosa of eosinophilic otitis media (EOM). METHODS: An immunohistological study of TSLP was conducted in patients with EOM and in animal models of EOM constructed by intraperitoneal and intratympanic injection of ovalbumin for 7 and 14 days. In addition, the messenger RNA (mRNA) expression of TSLP in the middle ear mucosa of the animal models was analyzed using real-time PCR, and was compared with that of the control animals...
December 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29227445/mobile-hearing-testing-applications-and-the-diagnosis-of-sudden-sensorineural-hearing-loss-a-cautionary-tale
#16
Rosh K V Sethi, Iman Ghanad, Vivek Kanumuri, Barbara Herrmann, Elliott D Kozin, Aaron K Remenschneider
OBJECTIVE: Mobile hearing applications (apps) are available for hearing testing, personal sound amplification, as well as hearing aid modulation. Hearing testing apps are gaining popularity, especially in resource-limited settings. The reliability of mobile hearing testing apps, however, is not well characterized. PATIENTS/INTERVENTIONS: A case study of a single patient with a complaint of sudden hearing loss presenting to a tertiary-care hospital. MAIN OUTCOME MEASURE: Comparison of a mobile hearing testing app results with standard audiogram...
January 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29197586/ph-sensitive-polymeric-nanoparticles-with-antioxidant-and-anti-inflammatory-properties-against-cisplatin-induced-hearing-loss
#17
Sergio Martín-Saldaña, Raquel Palao-Suay, María Rosa Aguilar, Luis García-Fernández, Humberto Arévalo, Almudena Trinidad, Rafael Ramírez-Camacho, Julio San Román
Polymeric nanoparticles (NP) based on smart synthetic amphiphilic copolymers are used to transport and controlled release dexamethasone in the inner ear to protect against the ototoxic effect of cisplatin. The NP were based on a mixture of two pseudo-block polymer drugs obtained by free radical polymerization: poly(VI-co-HEI) and poly(VP-co-MVE) or poly(VP-co-MTOS), being VI 1-vinylimidazole, VP N-vinylpyrrolidone, and IBU, MVE and MTOS the methacrylic derivatives of ibuprofen, α-tocopherol and α-tocopheryl succinate, respectively...
November 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29168028/systemic-intratympanic-and-combined-administration-of-steroids-for-sudden-hearing-loss-a-prospective-randomized-multicenter-trial
#18
Michael Tsounis, George Psillas, Miltiadis Tsalighopoulos, Victor Vital, Nicolas Maroudias, Konstantinos Markou
PURPOSE: The purpose of this prospective, randomized, multicenter clinical trial was to compare the therapeutic efficacy of systemic versus intratympanic versus combined administration of steroids in the treatment of idiopathic sudden sensorineural hearing loss. METHODS: 102 patients with an up to 14 days history of idiopathic sudden sensorineural hearing loss were randomized to 1 of 3 arms and followed prospectively. Group A (35 patients) received prednisolone intravenously followed by methylprednisolone orally, whereas Group B (34 patients) were administered intratympanic methylprednisolone...
January 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29165312/the-role-of-high-dose-intratympanic-dexamethasone-as-salvage-therapy-for-idiopathic-sudden-sensorineural-hearing-loss
#19
Špela Kordiš, Saba Battelino
OBJECTIVE: The aim of this study was to assess the efficacy of a single high dose intratympanic (IT) dexamethasone (DEX) as salvage therapy for idiopathic sudden sensorineural hearing loss (ISSNHL) after unsuccessful treatment with oral corticosteroid (CS). MATERIALS AND METHODS: This was a prospective open-label study of 59 patients treated with IT DEX after systemic CS therapy has failed. All patients received high dose (24 mg/mL) IT DEX in a single injection through myringotomy...
December 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29160156/prestin-as-an-otologic-biomarker-of-cisplatin-ototoxicity-in-a-guinea-pig-model
#20
James Naples, Robert Cox, Gregory Bonaiuto, And Kourosh Parham
Objective To evaluate (1) whether changes in serum prestin aid in early detection of cisplatin ototoxicity, (2) the role of diltiazem as an otoprotectant, and (3) whether prestin levels are sensitive to effects of diltiazem. Study Design Experimental animal study. Setting Translational research laboratory. Subjects Twenty female guinea pigs. Methods Two groups of 10 guinea pigs were used. The relationship between serum prestin levels and auditory brainstem response (ABR) thresholds was compared between the groups...
November 1, 2017: Otolaryngology—Head and Neck Surgery
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