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Intratympanic

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https://www.readbyqxmd.com/read/28645678/endolymphatic-hydrops-imaging-differential-diagnosis-in-patients-with-meniere-disease-symptoms
#1
A Attyé, M Eliezer, A Galloux, J Pietras, I Tropres, S Schmerber, G Dumas, A Krainik
PURPOSE: The goal of this retrospective study was to investigate the differential diagnosis of endolymphatic hydrops in patients with Meniere's disease (MD) symptoms by using magnetic resonance imaging (MRI) with intravenous injection of gadolinium chelate and delayed acquisition. MATERIAL AND METHOD: Two hundred patients (133 women, 67 men; mean age=67.2±11 ([SD] years) with unilateral MD underwent MRI at 3-T, between 4.5 and 5.5hours after intravenous administration of gadoterate meglumine at a dose of 0...
June 20, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28639557/effects-of-selective-seratonine-re-uptake-inhibitors-on-meniere-s-disease
#2
Olcay Kıroğlu, Özgür Sürmelioğlu, Mete Kıroğlu
OBJECTIVE: To evaluate the effects of selective serotonin re-uptake inhibitors (SSRIs) on Meniere's disease (MD) on patients who have both MD and generalized anxiety disorder. MATERIALS AND METHODS: All patients were evaluated with neurotologic examination, videonystagmography, audiological tests, and inner ear magnetic resonance imaging. Characteristic history and the evaluation of the patients' vertigo attacks during the attacks were the primary criteria for the diagnosis of MD...
June 21, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28636736/the-protective-effect-of-intratympanic-dexamethasone-on-streptomycin-ototoxicity-in-rats
#3
Aylin Gül, Engin Şengül, Beyhan Yılmaz, Fazıl Emre Özkurt, Mehmet Akdağ, Ayşenur Keleş, İsmail Topçu
The purpose of this experimental study was to investigate the protective role of intratympanically administered dexamethasone on the inner ears of rats that were exposed to streptomycin ototoxicity. Twenty-four adult Wistar albino rats were separated into 4 groups: Group 1 (only streptomycin), Group 2 (only intratympanic dexamethasone), Group 3 (streptomycin and intratympanic dexamethasone), and Group 4 (streptomycin and intratympanic saline). All rats were evaluated with distortion product otoacoustic emissions (DPOAE) tests before the start of treatment and on the day it ended...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28608739/safety-of-repeated-dose-intratympanic-injections-with-am-101-in-acute-inner-ear-tinnitus
#4
Hinrich Staecker, Michael Morelock, Timothy Kramer, Pavel Chrbolka, Joong Ho Ahn, Thomas Meyer
Objective To evaluate the safety and tolerability of repeated intratympanic administration of the gel-formulated NMDA receptor antagonist AM-101 in acute patients with inner ear tinnitus. Study Design Prospective, double-blind, randomized, placebo-controlled study. Setting Sixty-nine secondary and tertiary sites in North America, Europe, and Asia. Subjects and Methods In total, 343 subjects with persistent acute tinnitus after traumatic cochlear injury or otitis media were randomized to receive 3 intratympanic doses of either AM-101 0...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607789/unilateral-enlarged-vestibular-aqueduct-syndrome-and-bilateral-endolymphatic-hydrops
#5
Massimo Ralli, Giuseppe Nola, Luca Sparvoli, Giovanni Ralli
Enlarged vestibular aqueduct (EVA) syndrome is a common congenital inner ear malformation characterized by a vestibular aqueduct with a diameter larger than 1.5 mm, mixed or sensorineural hearing loss that ranges from mild to profound, and vestibular disorders that may be present with a range from mild imbalance to episodic objective vertigo. In our study, we present the case of a patient with unilateral enlarged vestibular aqueduct and bilateral endolymphatic hydrops (EH). EH was confirmed through anamnestic history and audiological exams; EVA was diagnosed using high-resolution CT scans and MRI images...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28589104/intratympanic-injection-of-dexamethasone-and-electrocochleographic-data-in-cases-of-definite-one-sided-refractory-meniere-s-disease
#6
Sasan Dabiri Satri, Reza Gharibi, Farzaneh Nejadian, Nasrin Yazdani, Reza Hoseinabadi, Nima Rezazadeh, Mohammad Reza Firouzifar, Saeed Babaei
INTRODUCTION: Meniere's disease (MD) is a disease of the inner ear that presents itself with repeated episodes of vertigo (96.2%), tinnitus (91.1%), and sensorineural hearing loss (87.7 %). In this article we sought to assess the effects of intratympanic (IT) injections of dexamethasone on definite cases of MD using electrocochleography (ECOG). MATERIALS AND METHODS: In this hospital-based case series in 36 patients, we measured audiometric values and ECOG in all patients before, 1 month and 6 months after 4-mg/mL IT injections of dexamethasone...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28549377/biocompatibility-of-liposome-nanocarriers-in-the-rat-inner-ear-after-intratympanic-administration
#7
Jing Zou, Hao Feng, Rohit Sood, Paavo K J Kinnunen, Ilmari Pyykko
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration. However, information on the biocompatibility of LPNs in the inner ear is lacking. The aim of the present study is to document the biocompatibility of LPNs in the inner ear after intratympanic delivery. LPNs with or without gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) were delivered to the rats through transtympanic injection...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28538472/efficacy-of-intratympanic-gentamicin-in-m%C3%A3-ni%C3%A3-re-s-disease-with-and-without-migraine
#8
Yuan F Liu, Elizabeth Renk, Steven D Rauch, Helen X Xu
OBJECTIVE: To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Ménière's disease patients with and without a history of migraine. PATIENTS: Ménière's disease patients (patients with migraine and age- and sex-matched control patients without migraine) treated from 2002 to 2012 who failed medical management and received ITG, with a minimum 2-year follow up. INTERVENTION: ITG...
May 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28511890/intratympanic-steroid-delivery-by-an-indwelling-catheter-in-refractory-severe-sudden-sensorineural-hearing-loss
#9
Diego Zanetti, Federica Di Berardino, Nader Nassif, Luca Oscar Redaelli De Zinis
OBJECTIVE: Many studies over the last decade showed favorable outcomes with intratympanic (IT) steroid treatment, alone as salvage treatment or in combination with conventional systemic therapy (ST). However, in severe to profound sensorineural hearing loss resistant to ST, the optimal infusion mode, the type and concentration of the solution, the preferable drug, its total amount, and the duration and fractionation of the treatment are still debated. Aim of the study was to investigate the feasibility and the outcomes of a direct and constant IT delivery of dexamethasone (DEX) by means of a new indwelling catheter...
May 13, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28499297/-diagnostics-and-therapy-of-idiopathic-sudden-sensorineural-hearing-loss
#10
Stefan K Plontke
This article reviews recent aspects of diagnostics, differential diagnostics and evidence in systemic and local therapy of idiopathic, sudden, sensorineural hearing loss (ISSHL). Since a number of disorders can be accompanied by sudden hearing loss a meaningful and targeted diagnostic strategy is of utmost importance. An important differential diagnosis of sudden hearing loss are intralabyrinthine schwannomas (ILS). The incidence of ILS is probably significantly underestimated. This may be due to the lack of awareness or lack of explicit search for an intralabyrinthine tumor on MRI or an inappropriate MRI technique ('head-MRI' instead of 'temporal bone-MRI' with too high slice thickness) for the evaluation of sudden hearing loss...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28483257/protective-role-of-intratympanic-nigella-sativa-oil-against-gentamicin-induced-hearing-loss
#11
Deniz Tuna Edizer, Ozgur Yigit, Zehra Cinar, Mehmet Gul, Eyyup Kara, Birgul Yigitcan, Duygu Hayır, Ahmet Atas
OBJECTIVE: Aminoglycosides, used to combat with life-threatening infections, have a substantial risk of hearing loss. Nigella sativa is an annual herbaceous plant and used for treatment of many diseases for ages. We aimed to investigate the protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss in an animal model. METHODS AND MATERIALS: Twenty eight guinea pigs were randomly divided into four groups: i-control, ii- Intratympanic nigella sativa oil (IT-NSO), iii- Intraperitoneal gentamicin (IP-G) and iv- Intraperitoneal gentamicin and intratympanic nigella sativa oil (IP-G + IT-NSO)...
June 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28462501/innovative-pharmaceutical-approaches-for-the-management-of-inner-ear-disorders
#12
REVIEW
Umberto M Musazzi, Silvia Franzé, Francesco Cilurzo
The sense of hearing is essential for permitting human beings to interact with the environment, and its dysfunctions can strongly impact on the quality of life. In this context, the cochlea plays a fundamental role in the transformation of the airborne sound waves into electrical signals, which can be processed by the brain. However, several diseases and external stimuli (e.g., noise, drugs) can damage the sensorineural structures of cochlea, inducing progressive hearing dysfunctions until deafness. In clinical practice, the current pharmacological approaches to treat cochlear diseases are based on the almost exclusive use of systemic steroids...
May 1, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28437363/intratympanic-dexamethasone-in-the-treatment-of-m%C3%A3-ni%C3%A3-re-s-disease-a-comparison-of-two-techniques
#13
Jason A Beyea, Ryan S Instrum, Sumit K Agrawal, Lorne S Parnes
OBJECTIVE: To assess the efficacy and safety of two different intratympanic dexamethasone (IT Dex) injection protocols for intractable unilateral Ménière's disease. STUDY DESIGN: Prospective case series. SETTING: Tertiary neurotology clinic. PATIENTS: One hundred six consecutive adult patients with definite unilateral Ménière's disease who had failed medical management were studied for an average of 1,061 days. None had previous oral steroid, IT steroid, or ablative treatment...
July 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28434389/evaluation-of-the-protective-effect-of-botulinum-toxin-type-a-injection-on-otitis-media-with-effusion
#14
Ömer Faruk Çalım, Yavuz Selim Yıldırım, Remzi Doğan, Selhattin Tuğrul, Özge Gedik, Orhan Özturan
OBJECTIVE: This study makes an analysis of the effect of Botulinum toxin type A on otitis media with effusion in rats. METHOD: As part of the study, 24 male Wistar Albino rats were divided into three groups: Group 1: Botulinum toxin Type A and Histamıne (intratympanic 0.2 ml = 20 unit BTA); Group 2: Saline and Histamine (intratympanic 0.2 ml 0.9%); Group 3: Histamine (intratympanic 0.2 ml). Histamine (intratympanic 0.2 ml) was administered into the right ear for all groups...
April 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28424655/sustained-and-transient-vestibular-systems-a-physiological-basis-for-interpreting-vestibular-function
#15
REVIEW
Ian S Curthoys, Hamish G MacDougall, Pierre-Paul Vidal, Catherine de Waele
Otolithic afferents with regular resting discharge respond to gravity or low-frequency linear accelerations, and we term these the static or sustained otolithic system. However, in the otolithic sense organs, there is anatomical differentiation across the maculae and corresponding physiological differentiation. A specialized band of receptors called the striola consists of mainly type I receptors whose hair bundles are weakly tethered to the overlying otolithic membrane. The afferent neurons, which form calyx synapses on type I striolar receptors, have irregular resting discharge and have low thresholds to high frequency (e...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28417102/prognostic-factors-for-recovery-from-sudden-sensorineural-hearing-loss-a-retrospective-study
#16
Woo Seok Kang, Chan Joo Yang, Myungjoo Shim, Chan Il Song, Tae Su Kim, Hyun Woo Lim, Joong Ho Ahn, Hong Ju Park, Jong Woo Chung
BACKGROUND AND OBJECTIVES: This study aimed to investigate prognostic factors in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). SUBJECTS AND METHODS: From January 2007 to December 2011, a retrospective chart review identified 494 consecutive patients with ISSNHL. Demographic, audiometric, and clinical data were analyzed using a logistic regression test. RESULTS: Hearing recovery from ISSNHL was significantly associated with factors such as age, duration from onset of symptoms to commencement of treatment, severity of the initial pure tone threshold, and the treatment method...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28413076/detection-of-endolymphatic-hydrops-using-traditional-mr-imaging-sequences
#17
John H Keller, Barry E Hirsch, Ryan S Marovich, Barton F Branstetter
PURPOSE: The purpose of this study was to determine whether Meniere's disease (MD) produces endolymphatic cavity size changes that are detectable using unenhanced high-resolution T2-weighted MRI. MATERIALS & METHODS: This retrospective case-control study included patients with documented MD who had a high-resolution T2-weighted or steady-state free procession MRI of the temporal bones within one month of diagnosis, between 2002 and 2015. Patients were compared to age- and sex- matched controls...
April 6, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28384627/simultaneous-versus-sequential-intratympanic-steroid-treatment-for-severe-to-profound-sudden-sensorineural-hearing-loss
#18
Myung Hoon Yoo, Won Sub Lim, Joo Hyun Park, Joong Keun Kwon, Tae-Hoon Lee, Yong-Hwi An, Young-Jin Kim, Jong Yang Kim, Hyun Woo Lim, Hong Ju Park
OBJECTIVES: Severe-to-profound sudden sensorineural hearing loss (SSNHL) has a poor prognosis. We aimed to compare the efficacy of simultaneous and sequential oral and intratympanic steroids for this condition. METHODS: Fifty patients with severe-to-profound SSNHL (>70 dB HL) were included from 7 centers. The simultaneous group (27 patients) received oral and intratympanic steroid injections for 2 weeks. The sequential group (23 patients) was treated with oral steroids for 2 weeks and intratympanic steroids for the subsequent 2 weeks...
2016: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/28376942/voice-in-t1b-glottic-tumours-intratympanic-steroids-for-salvage-in-sensorineural-hearing-loss-intranasal-steroids-for-obstructive-sleep-apnoea-and-a-new-procedure-for-post-radiation-nasal-stenosis
#19
Musheer Hussain, Edward Fisher, Robin Youngs, Jonathan Fishman
No abstract text is available yet for this article.
May 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28362376/a-comparative-study-of-drug-delivery-methods-targeted-to-the-mouse-inner-ear-bullostomy-versus-transtympanic-injection
#20
Silvia Murillo-Cuesta, Néstor Vallecillo, Rafael Cediel, Adelaida M Celaya, Luis Lassaletta, Isabel Varela-Nieto, Julio Contreras
We present two minimally invasive microsurgical techniques in rodents for specific drug delivery into the middle ear so that it may reach the inner ear. The first procedure consists of perforation of the tympanic bulla, termed bullostomy; the second one is a transtympanic injection. Both emulate human clinical intratympanic procedures. Chitosan-glycerophosphate (CGP) and Ringer´s Lactate buffer (RL) were used as biocompatible vehicles for local drug delivery. CGP is a nontoxic biodegradable polymer widely used in pharmaceutical applications...
March 8, 2017: Journal of Visualized Experiments: JoVE
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