Jiali Wang, Chong Wang, Qiao Wang, Zhuohao Zhang, Hui Wang, Shengyi Wang, Zhangcai Chi, Luoran Shang, Wuqing Wang, Yilai Shu
Local drug delivery has become an effective method for disease therapy in fine organs including ears, eyes, and noses. However, the multiple anatomical and physiological barriers, unique clearance pathways, and sensitive perceptions characterizing these organs have led to suboptimal drug delivery efficiency. Here, we developed dexamethasone sodium phosphate-encapsulated gelatin methacryloyl (Dexsp@GelMA) microgel particles, with finely tunable size through well-designed microfluidics, as otic drug delivery vehicles for hearing loss therapy...
October 19, 2022: ACS Applied Materials & Interfaces