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https://www.readbyqxmd.com/read/28734488/clinical-fellowship-for-an-innovative-integrated-bsn-phd-program-an-academic-and-practice-partnership
#1
Madelyne Z Greene, Mary Kate FitzPatrick, Jean Romano, Linda H Aiken, Therese S Richmond
Opportunities for research-focused doctoral education must be available to nurses early in their careers in order to ensure the further development of nursing science. Early entry into the research doctorate through an integrated BSN-PhD program is one innovative approach. This approach highlights the value of integrating post-licensure clinical training into the doctoral curriculum. To better prepare innovative nurse scientists early in their careers we developed a clinical nurse fellowship within an integrated BSN-PhD program in partnership with an affiliated health system...
July 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28733914/molecular-and-functional-analysis-of-monoclonal-antibodies-in-support-of-biologics-development
#2
REVIEW
Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia, Qinjian Zhao
Monoclonal antibody (mAb)-based therapeutics are playing an increasingly important role in the treatment or prevention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi-domain mAbs are far more complex than small molecule drugs with intrinsic heterogeneities. The critical quality attributes of a given mAb, including structure, post-translational modifications, and functions at biomolecular and cellular levels, need to be defined and profiled in details during the developmental phases of a biologics...
July 21, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28731898/steady-progress-toward-a-malaria-vaccine
#3
Kirsten E Lyke
PURPOSE OF REVIEW: Great progress has been made in reducing malaria morbidity and mortality, yet the parasite continues to cause a startling 200 million infections and 500 000 deaths annually. Malaria vaccine development is pushing new boundaries by steady advancement toward a licensed product. RECENT FINDINGS: Despite 50 years of research, the complexity of Plasmoidum falciparum confounds all attempts to eradicate the organism. This very complexity has pushed the boundaries of vaccine development to new heights, yet it remains to be seen if an affordable vaccine can provide durable and high-level protection...
July 20, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28730271/serious-adverse-events-after-hpv-vaccination-a-critical-review-of-randomized-trials-and-post-marketing-case-series
#4
Manuel Martínez-Lavín, Luis Amezcua-Guerra
This article critically reviews HPV vaccine serious adverse events described in pre-licensure randomized trials and in post-marketing case series. HPV vaccine randomized trials were identified in PubMed. Safety data were extracted. Post-marketing case series describing HPV immunization adverse events were reviewed. Most HPV vaccine randomized trials did not use inert placebo in the control group. Two of the largest randomized trials found significantly more severe adverse events in the tested HPV vaccine arm of the study...
July 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28728590/chikungunya-virus-infection-in-cynomolgus-macaques-following-intradermal-and-aerosol-exposure
#5
Chris M Cirimotich, Eric M Vela, Jennifer Garver, Roy E Barnewall, Brian D Miller, Gabriel T Meister, James V Rogers
BACKGROUND: Chikungunya virus (CHIKV) is transmitted via mosquito bite and potentially by aerosol, causing chikungunya fever and arthritic disease in humans. There are currently no licensed vaccines or antiviral therapeutics to protect against CHIKV infection in humans. Animal models recapitulating human disease, especially for transmission by aerosol, are needed for licensure of such medical countermeasures. METHODS: Cynomolgus macaques (CMs) were challenged by intradermal (ID) inoculation or exposure to an aerosol containing CHIKV Ross strain at different target infectious doses (10(3)-10(7) plaque forming units (PFU))...
July 20, 2017: Virology Journal
https://www.readbyqxmd.com/read/28724343/vero-cell-technology-for-rapid-development-of-inactivated-whole-virus-vaccines-for-emerging-viral-diseases
#6
P Noel Barrett, Sara J Terpening, Doris Snow, Ronald R Cobb, Otfried Kistner
Rapid development and production of vaccines against emerging diseases requires well established, validated, robust technologies to allow industrial scale production and accelerated licensure of products. Areas covered: A versatile Vero cell platform has been developed and utilized to deliver a wide range of candidate and licensed vaccines against emerging viral diseases. This platform builds on the 35 years' experience and safety record with inactivated whole virus vaccines such as polio vaccine. The current platform has been optimized to include a novel double inactivation procedure in order to ensure a highly robust inactivation procedure for novel emerging viruses...
July 20, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28686234/opposing-maintenance-of-certification-moc-and-the-interstate-medical-licensure-compact
#7
David Kahn
No abstract text is available yet for this article.
July 5, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28675587/invasive-pneumococcal-disease-in-children-with-sickle-cell-disease-in-the-pneumococcal-conjugate-vaccine-era
#8
Olufunke O Martin, Kristin L Moquist, Jane M Hennessy, Stephen C Nelson
Invasive pneumococcal disease (IPD) in children with sickle cell disease (SCD) can be devastating. We sought to assess the impact of IPD in children with SCD since licensure of the pneumococcal conjugate vaccines (PCVs). We found 11 cases of IPD giving an incidence of 417 per 100,000 person-years, much higher than that reported in children without SCD. Although all isolates were sensitive to penicillin, 89% of isolates were nonvaccine serotypes. Further study is needed to characterize the incidence of and risk factors for the development of IPD in SCD in the PCV era to help drive better prevention strategies...
July 4, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28670150/predicting-united-states-medical-licensure-examination-step-2-clinical-knowledge-scores-from-previous-academic-indicators
#9
Kristina A Monteiro, Paul George, Richard Dollase, Luba Dumenco
The use of multiple academic indicators to identify students at risk of experiencing difficulty completing licensure requirements provides an opportunity to increase support services prior to high-stakes licensure examinations, including the United States Medical Licensure Examination (USMLE) Step 2 clinical knowledge (CK). Step 2 CK is becoming increasingly important in decision-making by residency directors because of increasing undergraduate medical enrollment and limited available residency vacancies. We created and validated a regression equation to predict students' Step 2 CK scores from previous academic indicators to identify students at risk, with sufficient time to intervene with additional support services as necessary...
2017: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/28663940/considerations-for-use-of-investigational-drugs-in-public-health-emergencies
#10
Matthew Carl Kirchoff, Jerome F Pierson
The paradigm for the use of investigational drugs in public health emergencies has been recently tested to prevent and treat highly infectious and lethal diseases. Examples include the successful implementation of vaccine and therapeutic clinical trials during the recent Ebola outbreak in West Africa. On the other end of the spectrum was the Emergency Use Authorization (EUA) of peramivir in the treatment of H1N1 influenza virus that did not provide an opportunity to collect data or understand the effectiveness of the EUA program...
March 2017: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/28662258/collaborative-baccalaureate-programs-preliminary-data-on-canadian-undergraduate-nursing-students-satisfaction
#11
Laurie Freeman-Gibb, Beverley Jones, Selina Rehman, Janet Ragier
BACKGROUND: Ten years ago, nursing education in Ontario, Canada, changed when entry to practice and licensure became a bachelor's of science in nursing (BScN) for RNs. This article presents the initial results of an ongoing 5-year longitudinal study on undergraduate students' satisfaction within a collaborative BScN program and predictors of satisfaction with their nursing education. METHOD: BScN nursing students from one group of collaborative sites participated in a survey pertaining to satisfaction with their program...
July 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28660679/do-avoidable-hospitalization-rates-among-older-adults-differ-by-geographic-access-to-primary-care-physicians
#12
Michael R Daly, Jennifer M Mellor, Marco Millones
OBJECTIVE: To investigate the association between older adults' potentially avoidable hospitalization rates and both a geographic measure of primary care physician (PCP) access and a standard bounded-area measure of PCP access. DATA SOURCES: State physician licensure data from the Virginia Board of Medicine. Patient-level hospital discharge data from Virginia Health Information. Area-level data from the American Community Survey and the Area Health Resources Files...
June 28, 2017: Health Services Research
https://www.readbyqxmd.com/read/28654768/a-systematic-review-of-sexual-and-reproductive-health-care-content-in-nursing-curricula
#13
Joyce Cappiello, Leah Coplon, Holly Carpenter
OBJECTIVE: To examine whether and to what extent pre-licensure nursing programs include sexual and reproductive health (SRH) content in their curricula. DATA SOURCES: Electronic databases, including CINAHL, MEDLINE, PubMed, Web of Science, Science Direct, Google Scholar, ProQuest, and CAB Direct were searched for relevant literature. We also reviewed the reference lists of all studies, nursing organization Web sites, and the personal files of the authors. STUDY SELECTION: Inclusion criteria were studies focused on SRH content in pre-licensure nursing education, written in English, and published between January 1990 and November 2016...
June 24, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28651840/the-role-of-anti-nhba-antibody-in-bactericidal-activity-elicited-by-the-meningococcal-serogroup-b-vaccine-menb-4c
#14
Elizabeth Partridge, Eduardo Lujan, Serena Giuntini, David M Vu, Dan M Granoff
BACKGROUND: MenB-4C (Bexsero®) is a multicomponent serogroup B meningococcal vaccine. For vaccine licensure, efficacy was inferred from serum bactericidal antibody (SBA) against three antigen-specific indicator strains. The bactericidal role of antibody to the fourth vaccine antigen, Neisserial Heparin binding antigen (NHba), is incompletely understood. METHODS: We identified nine adults immunized with two or three doses of MenB-4C who had sufficient volumes of sera and >3-fold increases in SBA titer against a strain with high NHba expression, which was mismatched with the other three MenB-4C antigens that elicit SBA...
June 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28648544/risk-of-intussusception-following-rotavirus-vaccination-an-evidence-based-meta-analysis-of-cohort-and-case-control-studies
#15
Priya Kassim, Guy D Eslick
BACKGROUND: International post-licensure studies on rotavirus vaccines have identified an increased risk of intussusception in infants after administration. The first developed rotavirus vaccine (Rotashield (RRV-TV)) was suspended post-licensure in 1999 after an association with intussusception was found. The currently available second-generation rotavirus vaccines (Rotateq (RV5) and Rotarix (RV1)), are recommended as a routine vaccine by the World Health Organisation (WHO). Post-licensure studies of these vaccines have shown a smaller but temporal increased risk for developing intussusception...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28647170/the-complexity-and-cost-of-vaccine-manufacturing-an-overview
#16
REVIEW
Stanley Plotkin, James M Robinson, Gerard Cunningham, Robyn Iqbal, Shannon Larsen
As companies, countries, and governments consider investments in vaccine production for routine immunization and outbreak response, understanding the complexity and cost drivers associated with vaccine production will help to inform business decisions. Leading multinational corporations have good understanding of the complex manufacturing processes, high technological and R&D barriers to entry, and the costs associated with vaccine production. However, decision makers in developing countries, donors and investors may not be aware of the factors that continue to limit the number of new manufacturers and have caused attrition and consolidation among existing manufacturers...
June 21, 2017: Vaccine
https://www.readbyqxmd.com/read/28644277/newscap-more-states-enact-enhanced-nurse-licensure-compact-enlc-legislation
#17
(no author information available yet)
No abstract text is available yet for this article.
July 2017: American Journal of Nursing
https://www.readbyqxmd.com/read/28644223/how-pas-became-licensed-to-practice-in-the-united-states
#18
Alfred M Sadler, Ann Davis
The history of how PAs in the United States were first granted practice authority under the medical practice acts of the various states and territories begins in the 1960s with an imaginative way to circumvent the moratorium on licensure of new healthcare occupations in place at the time, while allowing the requisite flexibility for the new profession to take hold and thrive. In the subsequent decades, separate licensure for PAs was required and adopted. Despite the enormous success of the PA profession over its first 50 years, challenges remain...
July 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28640005/intussusception-related-hospitalizations-among-infants-before-and-after-private-market-licensure-of-rotavirus-vaccines-in-taiwan-2001-2013
#19
Catherine Yen, Shu-Man Shih, Jacqueline E Tate, Fang-Tzy Wu, Yhu-Chering Huang, Umesh D Parashar, Chao A Hsiung
INTRODUCTION: Rotavirus is a leading cause of acute gastroenteritis among Taiwanese children. Two globally licensed rotavirus vaccines recommended for inclusion in routine immunization programs that have been available for private market use in Taiwan since 2006 have been associated with a low risk of intussusception in post-marketing studies conducted in several countries. Our objective was to examine trends and characteristics of intussusception hospitalizations in Taiwan among children aged <12 months before and after rotavirus vaccine licensure to provide updated baseline and early post-licensure data...
June 17, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28632425/factors-influencing-occupational-therapists-decision-to-supervise-fieldwork-students
#20
Joscelyn Varland, Elizabeth Cardell, Jeanette Koski, Molly McFadden
The purpose of this study was to identify factors that influence the decision to supervise a Level II occupational therapy fieldwork student. A survey was sent to occupational therapists identified from licensure boards and alumni rosters, including those who have and have not supervised students (n = 548). The results identified both positive and negative influences along with predictive factors of supervising a student. While positive factors included continuing education units, education on fieldwork expectations, their own fieldwork experiences, shared supervision, and access to educational resources, negative influences consisted of: job responsibilities, caseload, productivity standards, working part-time, and fear of failing a student...
June 20, 2017: Occupational Therapy in Health Care
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