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https://www.readbyqxmd.com/read/28444323/effectiveness-of-rotavirus-vaccination-a-systematic-review-of-the-first-decade-of-global-post-licensure-data-2006-2016
#1
Christine L Jonesteller, Eleanor Burnett, Catherine Yen, Jacqueline E Tate, Umesh D Parashar
Two rotavirus vaccines, Rotarix (RV1) and RotaTeq (RV5), were licensed for global use in 2006. A systematic review of 48 peer-reviewed articles with post-licensure data from 24 countries showed a median RV1 vaccine effectiveness (VE) of 84%, 75%, and 57% in low, medium, and high child mortality countries, respectively, and RV5 VE of 90% in low and 45% in high child mortality countries. A partial vaccine series provided considerable protection, but not to the same level as a full series. VE tended to decline in the second year of life, particularly in medium and high mortality settings, and tended to be greater against more severe rotavirus disease...
April 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28442230/case-control-vaccine-effectiveness-studies-data-collection-analysis-and-reporting-results
#2
REVIEW
Jennifer R Verani, Abdullah H Baqui, Claire V Broome, Thomas Cherian, Cheryl Cohen, Jennifer L Farrar, Daniel R Feikin, Michelle J Groome, Rana A Hajjeh, Hope L Johnson, Shabir A Madhi, Kim Mulholland, Katherine L O'Brien, Umesh D Parashar, Manish M Patel, Laura C Rodrigues, Mathuram Santosham, J Anthony Scott, Peter G Smith, Halvor Sommerfelt, Jacqueline E Tate, J Chris Victor, Cynthia G Whitney, Anita K Zaidi, Elizabeth R Zell
The case-control methodology is frequently used to evaluate vaccine effectiveness post-licensure. The results of such studies provide important insight into the level of protection afforded by vaccines in a 'real world' context, and are commonly used to guide vaccine policy decisions. However, the potential for bias and confounding are important limitations to this method, and the results of a poorly conducted or incorrectly interpreted case-control study can mislead policies. In 2012, a group of experts met to review recent experience with case-control studies evaluating vaccine effectiveness; we summarize the recommendations of that group regarding best practices for data collection, analysis, and presentation of the results of case-control vaccine effectiveness studies...
April 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28434944/dose-dependent-t-cell-dynamics-and-cytokine-cascade-following-rvsv-zebov-immunization
#3
Christine Dahlke, Rahel Kasonta, Sebastian Lunemann, Verena Krähling, Madeleine E Zinser, Nadine Biedenkopf, Sarah K Fehling, My L Ly, Anne Rechtien, Hans C Stubbe, Flaminia Olearo, Saskia Borregaard, Alen Jambrecina, Felix Stahl, Thomas Strecker, Markus Eickmann, Marc Lütgehetmann, Michael Spohn, Stefan Schmiedel, Ansgar W Lohse, Stephan Becker, Marylyn M Addo
BACKGROUND: The recent West African Ebola epidemic led to accelerated efforts to test Ebola vaccine candidates. As part of the World Health Organisation-led VSV Ebola Consortium (VEBCON), we performed a phase I clinical trial investigating rVSV-ZEBOV (a recombinant vesicular stomatitis virus-vectored Ebola vaccine), which has recently demonstrated protection from Ebola virus disease (EVD) in phase III clinical trials and is currently in advanced stages of licensing. So far, correlates of immune protection are incompletely understood and the role of cell-mediated immune responses has not been comprehensively investigated to date...
April 5, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28430997/global-impact-of-rotavirus-vaccination-on-childhood-hospitalizations-and-mortality-from-diarrhea
#4
Eleanor Burnett, Christine L Jonesteller, Jacqueline E Tate, Catherine Yen, Umesh D Parashar
In 2006, two rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from high child mortality countries. We used standardized guidelines (PRISMA) guidelines to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data...
April 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28401577/a-brief-report-on-the-ethical-and-legal-guides-for-technology-use-in-marriage-and-family-therapy
#5
Michael Pennington, Rikki Patton, Amber Ray, Heather Katafiasz
Marriage and family therapists (MFTs) use ethical codes and state licensure laws/rules as guidelines for best clinical practice. It is important that professional codes reflect the potential exponential use of technology in therapy. However, current standards regarding technology use lack clarity. To explore this gap, a summative content analysis was conducted on state licensure laws/rules and professional ethical codes to find themes and subthemes among the many aspects of therapy in which technology can be utilized...
April 12, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28399824/long-term-impact-of-self-financed-rotavirus-vaccines-on-rotavirus-associated-hospitalizations-and-costs-in-the-valencia-region-spain
#6
Alejandro Orrico-Sanchez, Mónica López-Lacort, Silvia Pérez-Vilar, Javier Díez-Domingo
BACKGROUND: Rotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hospitalization rate reduction of rotavirus caused gastroenteritis (RVAGE) directly attributable to vaccination remains unclear due to the large differences described in published studies, ranging from 14 to 44.5% in children <5 years of age, even with similar vaccination coverage...
April 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28398984/experiences-of-pre-licensure-or-pre-registration-health-professional-students-and-their-educators-in-working-with-intra-professional-teams-a-qualitative-systematic-review
#7
Diane L Butcher, Karen MacKinnon, Anne Bruce, Carol Gordon, Clare Koning
BACKGROUND: Inter-professional initiatives are prevalent in the healthcare landscape, requiring professionals to collaborate effectively to provide quality patient care. Little attention has been given to intra-professional relationships, where professionals within one disciplinary domain (such as degree and diploma nursing students) collaborate to provide care. New care models are being introduced where baccalaureate and diploma students of a particular discipline (such as nursing, occupational therapy, dentistry or physiotherapy) work closely together in teams to deliver care...
April 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28391739/taxonomy-for-education-and-training-in-clinical-neuropsychology-past-present-and-future
#8
Scott A Sperling, Cynthia R Cimino, Nikki H Stricker, Amy K Heffelfinger, Jennifer L Gess, Katie E Osborn, Brad L Roper
OBJECTIVE: Historically, the clinical neuropsychology training community has not clearly or consistently defined education or training opportunities. The lack of consistency has limited students' and trainees' ability to accurately assess and compare the intensity of neuropsychology-specific training provided by programs. To address these issues and produce greater 'truth in advertising' across programs, CNS, with SCN's Education Advisory Committee (EAC), ADECN, AITCN, and APPCN constructed a specialty-specific taxonomy, namely, the Taxonomy for Education and Training in Clinical Neuropsychology...
April 10, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28384325/decrease-of-invasive-pneumococcal-disease-ipd-in-adults-after-introduction-of-pneumococcal-13-valent-conjugate-vaccine-in-spain
#9
Jordi Càmara, José María Marimón, Emilia Cercenado, Nieves Larrosa, María Dolores Quesada, Dionísia Fontanals, Meritxell Cubero, Emilio Pérez-Trallero, Asunción Fenoll, Josefina Liñares, Carmen Ardanuy
A prospective laboratory-based multicenter study that collected all adult invasive pneumococcal disease (IPD) episodes from 6 Spanish hospitals before (2008-2009) and after (2012-2013). The 13-valent pneumococcal conjugate vaccine (PCV13) licensure was conducted in order to analyze the impact of PCV13 introduction for children on adult IPD. A total of 1558 IPD episodes were detected. The incidence of IPD decreased significantly in the second period by -33.9% (95% CI, -40.3% to -26.8%). IPD due to PCV7 serotypes (-52...
2017: PloS One
https://www.readbyqxmd.com/read/28383331/the-path-to-advanced-practice-licensure-for-clinical-nurse-specialists-in-washington-state
#10
Heather Schoonover
PURPOSE: The aim of this study was to provide a review of the history and process to obtaining advanced practice licensure for clinical nurse specialists in Washington State. Before 2016, Washington State licensed certified nurse practitioners, certified nurse midwives, and certified nurse anesthetists under the designation of an advanced registered nurse practitioner; however, the state did not recognize clinical nurse specialists as advanced practice nurses. The work to drive the rule change began in 2007...
May 2017: Clinical Nurse Specialist CNS
https://www.readbyqxmd.com/read/28376822/internationally-educated-nurses-in-canada-predictors-of-workforce-integration
#11
Christine L Covell, Marie-Douce Primeau, Kelley Kilpatrick, Isabelle St-Pierre
BACKGROUND: Global trends in migration accompanied with recent changes to the immigrant selection process may have influenced the demographic and human capital characteristics of internationally educated nurses (IENs) in Canada and in turn the assistance required to facilitate their workforce integration. This study aimed to describe the demographic and human capital profile of IENs in Canada, to explore recent changes to the profile, and to identify predictors of IENs' workforce integration...
April 4, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28376812/multi-walled-carbon-nanotubes-functionalized-with-recombinant-dengue-virus-3-envelope-proteins-induce-significant-and-specific-immune-responses-in-mice
#12
Alice F Versiani, Ruiz G Astigarraga, Eliseu S O Rocha, Ana Paula M Barboza, Erna G Kroon, Milene A Rachid, Daniele G Souza, Luiz O Ladeira, Edel F Barbosa-Stancioli, Ado Jorio, Flávio G Da Fonseca
BACKGROUND: Dengue is the most prevalent arthropod-borne viral disease in the world. In this article we present results on the development, characterization and immunogenic evaluation of an alternative vaccine candidate against Dengue. METHODS: The MWNT-DENV3E nanoconjugate was developed by covalent functionalization of carboxylated multi-walled carbon nanotubes (MWNT) with recombinant dengue envelope (DENV3E) proteins. The recombinant antigens were bound to the MWNT using a diimide-activated amidation process and the immunogen was characterized by TEM, AFM and Raman Spectroscopy...
April 4, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28375029/emerging-experience-with-meningococcal-serogroup-b-protein-vaccines
#13
REVIEW
Daniela Toneatto, Mariagrazia Pizza, Vega Masignani, Rino Rappuoli
The successful development of two broadly protective vaccines targeting Neisseria meningitidis serogroup B (MenB); 4CMenB and rLP2086, is the most significant recent advance in meningococcal disease prevention. Areas covered: Here we review the principles underlying the development of each vaccine and the novel methods used to estimate vaccine coverage. We update clinical and post-licensure experience with 4CMenB and rLP2086. Expert commentary: The immunogenicity and acceptable safety profile of 4CMenB and rLP2086 has been demonstrated in clinical trials...
May 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28374599/longitudinal-study-of-driver-licensing-rates-among-adolescents-and-young-adults-with-autism-spectrum-disorder
#14
Allison E Curry, Benjamin E Yerys, Patty Huang, Kristi B Metzger
Driving may increase mobility and independence for adolescents with autism without intellectual disability (autism spectrum disorder); however, little is known about rates of licensure. To compare the proportion of adolescents with and without autism spectrum disorder who acquire a learner's permit and driver's license, as well as the rate at which they progress through the licensing system, we conducted a retrospective cohort study of 52,172 New Jersey residents born in the years 1987-1995 who were patients of the Children's Hospital of Philadelphia healthcare network ⩾12 years of age; 609 (1...
April 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28372533/panel-6-vaccines
#15
Melinda M Pettigrew, Mark R Alderson, Lauren O Bakaletz, Stephen J Barenkamp, Anders P Hakansson, Kevin M Mason, Johanna Nokso-Koivisto, Janak Patel, Stephen I Pelton, Timothy F Murphy
Objective To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources PubMed database of the National Library of Science. Review Methods We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the searches to articles in English that were published between July 2011 and June 2015. Panel members reviewed literature in their area of expertise...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28371888/tobacco-nicotine-education-and-training-for-health-care-professional-students-and-practitioners-a-systematic-review
#16
Lisa Ye, Catherine Goldie, Tanvi Sharma, Sheila John, Megan Bamford, Patricia M Smith, Peter Selby, Annette Sh Schultz
Introduction: The objective of this systematic review was to investigate what education and training characteristics prepares and supports health-care professionals (HCPs) in the delivery of competent and effective care to clients who use tobacco-nicotine. Methods: A search of eight bibliographic databases for English-language peer-reviewed publications from January 2006 to March 2015. Studies were included if they met the a priori inclusion criteria, which consisted of: 1) quantitative study design, and 2) focus on tobacco-nicotine education or training for HCP students and practitioners...
March 29, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28364941/exploring-new-packaging-and-delivery-options-for-the-immunization-supply-chain
#17
REVIEW
Darin Zehrung, Courtney Jarrahian, Birgitte Giersing, Debra Kristensen
A variety of vaccine packaging and delivery technologies may benefit the immunization supply chain. These include alternative primary packaging, such as blow-fill-seal polymer containers, and novel delivery technologies, such intradermal delivery devices, microarray patches, and sublingual formulations of vaccines, and others in development. The potential timeline to availability of these technologies varies and depends on their stage of development and the type of data necessary to achieve licensure. Some new delivery devices are anticipated to be introduced in 2017, such as intradermal devices for delivery of inactivated poliovirus vaccine to stretch vaccine supplies due to a supply limitation...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28362462/impact-of-accreditation-standards-on-the-quality-of-continuing-nursing-education-activities-as-perceived-by-the-learner
#18
Elaine M Novakovich
BACKGROUND: Continuing nursing education (CNE) activities are increasingly becoming a requirement for RNs to maintain licensure or certification and to remain competent in practice in the fast-changing health care environment. Regardless of the health care profession, continuing education should be a quality educational experience to positively influence practice and patient outcomes. METHOD: A 15-item matrix based on the 2013 American Nurses Credentialing Center Primary Accreditation criteria was used to evaluate CNE activities...
April 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28358871/post-licensure-safety-evaluation-of-dihydroartemisinin-piperaquine-in-the-three-major-ecological-zones-across-ghana
#19
Abraham R Oduro, Seth Owusu-Agyei, Margaret Gyapong, Isaac Osei, Alex Adjei, Abena Yawson, Edward Sobe, Rita Baiden, Martin Adjuik, Fred Binka
BACKGROUND: Uncommon and rare adverse events (AEs), with delayed onset may not be detected before new drugs are licensed and deployed. The present study examined the post licensure safety of dihydroartemisinin-piperaquine (DHP) as an additional treatment for malaria in Ghana. The relationship between the incidence of AEs, treatment completion rate, participant characteristics and concomitant medications are reported. METHODS: A study conducted from September 2013 to June 2014 in Navrongo, Kintampo and Dodowa health research centres in Ghana is presented...
2017: PloS One
https://www.readbyqxmd.com/read/28356256/recent-progress-in-the-prevention-of-serogroup-b-meningococcal-disease
#20
Ian M Feavers, Martin C J Maiden
The widespread use of meningococcal polysaccharide conjugate vaccines has highlighted the challenge of providing protection against serogroup B disease. Over a period of four decades vaccine development has focused on sub-capsular, protein antigens, first with outer membrane vesicle (OMV) vaccines against epidemic outbreaks, and more recently on new multicomponent vaccines designed to offer better cross-protection against the antigenically diverse strains responsible for endemic disease. Because of the low incidence of meningococcal disease, the protective efficacy of these vaccines has not been determined in clinical studies and their licensure has been based on serological data; however, the serological assays used to predict protective coverage have limitations...
March 29, 2017: Clinical and Vaccine Immunology: CVI
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