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Intestinal alkaline phosphatase

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https://www.readbyqxmd.com/read/29446750/copaiba-oil-decreases-oxidative-stress-and-inflammation-but-not-colon-damage-in-rats-with-tnbs-induced-colitis
#1
Maiara Morseli Coelho Barbosa, Fernando Augusto Vicentini, Cristiane Vizioli Castro-Ghizoni, Osmar Alves Lameira, Anacharis Babeto Sa-Nakanishi, Livia Bracht, Rosane Marina Peralta, Maria Raquel Marçal Natali, Adelar Bracht, Jurandir Fernando Comar
BACKGROUND: TNBS-induced colitis is an experimental immunopathology in rats that shares many features with human inflammatory bowel diseases. Copaiba oleoresin is extracted from plants of the genus Copaifera and is shown to reduce inflammation. OBJECTIVE: to investigate the action of copaiba oil (C. reticulata Ducke) on inflammation and oxidative status in the distal colon of colitic rats. METHODS: Acute and subchronic colitis were induced in Wistar rats by an intracolonic enema with 2,4,6-trinitrobenzenesulfonic acid (TNBS)...
February 14, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29444320/effect-of-phytase-on-growth-performance-phytate-degradation-and-gene-expression-of-myo-inositol-transporters-in-the-small-intestine-liver-and-kidney-of-21-day-old-broilers
#2
C L Walk, M R Bedford, O A Olukosi
An experiment was conducted to evaluate phytase supplementation on growth, phytate degradation, and the gene expression of myo-inositol transporters in 21-day old broilers. Ross 308, male broilers (n = 240) were assigned to one of four diets, with 10 pens/diet and six birds/pen from day one to 21. The diets consisted of a negative control (NC) formulated to meet or exceed Ross 308 nutrient requirements, with the exception of calcium (Ca) and available P (avP), which were reduced by 0.16 and 0.15%, respectively...
February 12, 2018: Poultry Science
https://www.readbyqxmd.com/read/29443401/pediatric-intestinal-failure-associated-liver-disease-challenges-in-identifying-clinically-relevant-biomarkers
#3
Kathleen M Gura, Andrew E Mulberg, Paul D Mitchell, John Yap, Clara Y Kim, Minjun Chen, Alexis Potemkin, Mark Puder
BACKGROUND: Intestinal failure-associated liver disease (IFALD) is complex and diagnosed by concurrent use of parenteral nutrition, clinical presentation, and alterations in hepatic biomarkers exclusive of other causes of liver disease. In comparison with individual measures, composite biomarkers may provide a more effective means for assessing disease progression and response to treatment than single parameters. Since IFALD is considered by some to be a type of drug-induced liver injury (DILI), those diagnostic criteria could potentially be used in this population...
February 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29440901/guided-osteoporotic-bone-regeneration-with-composite-scaffolds-of-mineralized-ecm-heparin-membrane-loaded-with-bmp2-related-peptide
#4
Tingfang Sun, Man Liu, Sheng Yao, Yanhui Ji, Lei Shi, Kai Tang, Zekang Xiong, Fan Yang, Kaifang Chen, Xiaodong Guo
Introduction: At present, the treatment of osteoporotic defects poses a great challenge to clinicians, owing to the lower regeneration capacity of the osteoporotic bone as compared with the normal bone. The guided bone regeneration (GBR) technology provides a promising strategy to cure osteoporotic defects using bioactive membranes. The decellularized matrix from the small intestinal submucosa (SIS) has gained popularity for its natural microenvironment, which induces cell response. Materials and methods: In this study, we developed heparinized mineralized SIS loaded with bone morphogenetic protein 2 (BMP2)-related peptide P28 (mSIS/P28) as a novel GBR membrane for guided osteoporotic bone regeneration...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29438631/plasma-endocannabinoid-levels-in-lean-overweight-and-obese-humans-relationships-with-intestinal-permeability-markers-inflammation-and-incretin-secretion
#5
Tanya J Little, Nada Cvijanovic, Nicholas V DiPatrizio, Donovan A Argueta, Christopher K Rayner, Christine Feinle-Bisset, Richard L Young
INTRODUCTION/AIMS: Intestinal production of endocannabinoid and oleoylethanolamide (OEA) is impaired in high-fat diet/obese rodents, leading to reduced satiety. Such diets also alter the intestinal microbiome in association with enhanced intestinal permeability and inflammation, however little is known of these effects in humans. This study aimed to: (i) evaluate effects of lipid on plasma anandamide (AEA), 2-arachidonyl-sn-glycerol (2-AG) and OEA in humans, and (ii) examine relationships with intestinal permeability, inflammation markers and incretin hormone secretion...
February 13, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29436744/long-term-use-of-mixed-oil-lipid-emulsion-in-adult-home-parenteral-nutrition-patients-a-case-series
#6
Manpreet S Mundi, Megan T McMahon, Jennifer J Carnell, Ryan T Hurt
BACKGROUND: Despite providing significant benefits, home parenteral nutrition (HPN) can be associated with complications such as infections, intestinal failure-associated liver disease, and metabolic abnormalities. Soybean oil (SO)-based intravenous lipid emulsion (ILE) has been noted to contribute to some of these complications, leading to the development of alternative sources of ILE. Mixed-oil (MO) ILE has recently been approved for use in adults with short-term studies revealing a benefit over SO ILE...
February 13, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29427721/the-effects-singular-or-combined-administration-of-fermentable-fiber-and-probiotic-on-mucosal-immune-parameters-digestive-enzyme-activity-gut-microbiota-and-growth-performance-of-caspian-white-fish-rutilus-frisii-kutum-fingerlings
#7
Ali Taheri Mirghaed, Peyman Yarahmadi, Seyed Hossein Hosseinifar, Davood Tahmasebi, Nahid Gheisvandi, Alireza Ghaedi
The aim of the present study was to investigate the effects of single or combined administration of dietary fermentable fiber (Vitacel®) and probiotic PrimaLac® on mucosal immune parameters, digestive enzyme activity, gut microbiota and growth performance of Caspian white fish (Rutilus frisii kutum) fingerlings. Fish were transferred to laboratory, acclimatized for two weeks and then fish (0.56 ± 0.026 g) were allocated into 12 tanks (30 fish per tank). Triplicate groups were fed a basal diet (Control) or basal diet supplemented with fermentable fiber [Vitacel®] (FF), probiotic [PrimaLac®] (P) and combined fermentable fiber and probiotic (FF + P)...
February 7, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29416856/effects-of-bacillus-coagulans-supplementation-on-the-growth-performance-and-gut-health-of-broiler-chickens-with-clostridium-perfringens-induced-necrotic-enteritis
#8
Yuanyuan Wu, Yujing Shao, Bochen Song, Wenrui Zhen, Zhong Wang, Yuming Guo, Muhammad Suhaib Shahid, Wei Nie
Background: The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis (NE) due to Clostridium perfringens. Methods: This study was conducted to investigate the effects of feeding Bacillus coagulans on the growth performance and gut health of broiler chickens with C. perfringens-induced NE. Two hundred and forty 1-day-old broiler chicks were randomly assigned to a 2 × 2 factorial arrangement with two dietary B...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29408127/surface-phosphorylation-of-nanoparticles-by-hexokinase-a-powerful-tool-for-cellular-uptake-improvement
#9
Imran Nazir, Christina Leichner, Bao Le-Vinh, Andreas Bernkop-Schnürch
The aim of the study was to develop zeta potential changing nanoparticles (NPs) via surface phosphorylation in order to improve their uptake by epithelial cells. Polymeric NPs were formed via in situ gelation between chitosan (CS) and chondroitin sulphate (ChS). Phosphorylation of these NPs was carried out by using hexokinase. The resulting phosphorylated NPs (p-NPs) were characterized in respect of their size and zeta potential. Phosphate release was quantified by incubating the particles with isolated as well as cell-associated intestinal alkaline phosphatase (AP)...
January 30, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29395783/characterization-of-caco-2-cells-stably-expressing-the-protein-based-zinc-probe-ecalwy-5-as-a-model-system-for-investigating-intestinal-zinc-transport
#10
Maria Maares, Claudia Keil, Susanne Thomsen, Dorothee Günzel, Burkhard Wiesner, Hajo Haase
Intestinal zinc resorption, in particular its regulation and mechanisms, are not yet fully understood. Suitable intestinal cell models are needed to investigate zinc uptake kinetics and the role of labile zinc in enterocytes in vitro. Therefore, a Caco-2 cell clone was produced, stably expressing the genetically encoded zinc biosensor eCalwy-5. The aim of the present study was to reassure the presence of characteristic enterocyte-specific properties in the Caco-2-eCalwy clone. Comparison of Caco-2-WT and Caco-2-eCalwy cells revealed only slight differences regarding subcellular localization of the tight junction protein occludin and alkaline phosphatase activity, which did not affect basic integrity of the intestinal barrier or the characteristic brush border membrane morphology...
January 29, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29390901/tricyclic-coumarin-sulphonate-derivatives-with-alkaline-phosphatase-inhibitory-effects-in-vitro-and-docking-studies
#11
Jamshed Iqbal, Mohammed I El-Gamal, Syeda Abida Ejaz, Joanna Lecka, Jean Sévigny, Chang-Hyun Oh
Tissue-nonspecific alkaline phosphatase (TNAP) is an important isozyme of alkaline phosphatases, which plays different pivotal roles within the human body. Most importantly, it is responsible for maintaining the balanced ratio of phosphate and inorganic pyrophosphate, thus regulates the extracellular matrix calcification during bone formation and growth. The elevated level of TNAP has been linked to vascular calcification and end-stage renal diseases. Consequently, there is a need to search for highly potent and selective inhibitors of alkaline phosphatases (APs) for treatment of disorders associated with the over-expression of APs...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29382923/effect-of-a-fish-oil-based-lipid-emulsion-on-intestinal-failure-associated-liver-disease-in-children
#12
Tian Zhang, Nan Wang, Weihui Yan, Lina Lu, Yijing Tao, Fang Li, Ying Wang, Wei Cai
BACKGROUND/OBJECTIVES: The aim of this study was to assess the effects of a fish oil-based lipid emulsion on intestinal failure-associated liver disease (IFALD) in children. SUBJECTS/METHODS: From January 2014 through June 2017, we enrolled 32 children with IF on long-term parenteral nutrition (PN). When the levels of any three of seven liver indicators (TBA, alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase, gamma glutamyl transferase (γ-GT), total bilirubin (TB), or direct bilirubin (DB)) were two times higher than normal levels, we switched a 50:50 mix of soybean oil and medium-chain triglycerides (MCT) lipid emulsion (with an average dose of 1...
January 30, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29373684/the-effects-of-dietary-sulfur-amino-acids-on-growth-performance-intestinal-morphology-enzyme-activity-and-nutrient-transporters-in-weaning-piglets
#13
E Y Zong, P F Huang, H S Yang, W Zhang, J Z Li, Y L Li, X Q Ding, X Xiong, Y L Yin
Early weaning results in intestinal dysfunction in piglets while sulfur amino acids (SAA) are involved in improving intestinal functions. We tested a hypothesis that dietary supplementation with SAA can improve intestinal functions of weaning piglets and analyzed the effects of different dietary SAA levels on intestinal functions. A total of 80 piglets (Duroc × Landrace × Yorkshire) were weaned at 21 d of age and randomly assigned to one of five diets that contained 0.53, 0.63, 0.74, 0.85, or 0.96% SAA, which corresponded to 70, 85, 100, 115 or, 130% of the SAA:Lys ratio recommended by the NRC (2012)...
January 24, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29336925/a-novel-inactivated-vaccine-against-lawsonia-intracellularis-induces-rapid-induction-of-humoral-immunity-reduction-of-bacterial-shedding-and-provides-robust-gut-barrier-function
#14
F Roerink, C L Morgan, S M Knetter, M-H Passat, A L Archibald, T Ait-Ali, E L Strait
Porcine proliferative ileitis is a major economic burden for the swine industry, affecting growing pigs and young adult pigs. In this study, the protective efficacy of an inactivated, injectable whole-cell bacteria vaccine against L. intracellularis - Porcilis® Ileitis was evaluated under field conditions. Eighty-five, three-week-old pigs on a commercial farrow-to-finish farm were vaccinated by the intramuscular route, either with a dose of injectable vaccine, or with saline. A subset of vaccinates and control pigs were necropsied at 21 days post-challenge...
January 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29331981/variant-in-c-terminal-region-of-intestinal-alkaline-phosphatase-associated-with-benign-familial-hyperphosphatasaemia
#15
Takayuki Ishige, Sakae Itoga, Emi Utsuno, Motoi Nishimura, Masaharu Yoshikawa, Naoya Kato, Kazuyuki Matsushita, Osamu Yokosuka, Fumio Nomura
BACKGROUND: A genetic diagnosis has been rarely performed in benign familial hyperphosphatasaemia, and molecular mechanism largely remains unclear. OBJECTIVES: We encountered a case with benign familial hyperphosphatasaemia of intestinal alkaline phosphatase (IAP). To elucidate the molecular mechanism, we performed ALPI gene sequencing and in vitro protein expression analysis. METHODS: ALPI gene was sequenced by long-range PCR and massively parallel sequencing...
January 13, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29331348/effects-of-l-tryptophan-on-the-growth-intestinal-enzyme-activities-and-non-specific-immune-response-of-sea-cucumber-apostichopus-japonicus-selenka-exposed-to-crowding-stress
#16
Endong Zhang, Shuanglin Dong, Fang Wang, Xiangli Tian, Qinfeng Gao
In order to reveal the effects of l-tryptophan (Trp) on the physiology and immune response of sea cucumber (Apostichopus japonicus Selenka) exposed to crowding stress, four density groups of sea cucumbers (i.e. 4, 8, 16 and 32 individuals per 40 L water, represented as L, ML, MH and H) were fed with diets containing 0, 1, 3 and 5% l-tryptophan respectively for 75 days. The results showed that the specific growth rates (SGR) of the sea cucumber fed with diet with 3% Trp (L, 2.1; ML, 1.76; MH, 1.2; H, 0.7) were significantly higher than those fed with basal diet without Trp supplementation (P < ...
January 10, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29304440/evaluation-of-an-insect-meal-of-the-black-soldier-fly-hermetia-illucens-as-soybean-substitute-intestinal-morphometry-enzymatic-and-microbial-activity-in-laying-hens
#17
Monica Isabella Cutrignelli, Maria Messina, Francesca Tulli, Basilio Randazzi, Ike Olivotto, Laura Gasco, Rosa Loponte, Fulvia Bovera
This research investigated the ileum morphometry and enzymatic activity, the caecal volatile fatty acid production and the apparent nutrient digestibility in laying hens fed a Hermetia illucens larvae meal (HILM) as a complete replacement of diet soybean meal (SBM). The hens fed HILM exhibited a lower live weight (P<0.05) and a higher incidence of the full digestive tract (P<0.05) than the SBM group. In the duodenum, the maltase exhibited a higher (P<0.05) activity in the HILM group while the intestinal alkaline phosphatase (IAP) had a higher (P<0...
December 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29304153/effects-of-dietary-level-of-tannic-acid-and-protein-on-internal-organ-weights-and-biochemical-blood-parameters-of-rats
#18
Marcin Barszcz, Marcin Taciak, Anna Tuśnio, Jacek Skomiał
Tannic acid (TA) is a polyphenolic compound with a health-promoting potential for humans. It is hypothesised that TA effects on the relative weight of internal organs and biochemical blood indices are modified by dietary protein level in rats. The study involved 72 rats divided into 12 groups fed diets with 10 or 18% of crude protein (CP) and supplemented with 0, 0.25, 0.5, 1, 1.5 or 2% of TA. After 3 weeks of feeding, the relative weight of the caecum was greater in rats fed TA diets, while feeding diets with 10% of CP increased the relative weight of the stomach, small intestine and caecum, but decreased that of kidneys and spleen...
2018: PloS One
https://www.readbyqxmd.com/read/29291524/environmental-concentrations-of-antibiotics-impair-zebrafish-gut-health
#19
Li Zhou, Samwel Mchele Limbu, Meilin Shen, Wanying Zhai, Fang Qiao, Anyuan He, Zhen-Yu Du, Meiling Zhang
Antibiotics have been widely used in human and veterinary medicine to both treat and prevent disease. Due to their high water solubility and low bioavailability, many antibiotic residues have been found in aquatic environments. Fish are an indispensable link between the environmental pollution and human health. However, the chronic effects of environmental concentrations of antibiotics in fish have not been thoroughly investigated. Sulfamethoxazole (SMX) and oxytetracycline (OTC) are frequently detected in aquatic environments...
December 29, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29282608/dietary-application-of-the-probiotic-lactobacillus-plantarum-426951-enhances-immune-status-and-growth-of-rainbow-trout-oncorhynchus-mykiss-vaccinated-against-yersinia-ruckeri
#20
Mehdi Soltani, Komael Pakzad, Ali Taheri-Mirghaed, Saeed Mirzargar, Seyed Pezhman Hosseini Shekarabi, Parasto Yosefi, Narges Soleymani
This study was aimed to assess the effect of oral application of Lactobacillus plantarum (2 × 107 CFU g-1 feed) as a probiotic on growth performance and immune status of vaccinated rainbow trout (29.5 ± 2 g) to yersiniosis at 16 ± 2 °C for 72 days. Fish were randomly allocated into 12 fiber glass tanks (4100 L) at a density of 80 fish per tank (240 fish per treatment). The results revealed that the activity of lysozyme and alkaline phosphatase was significantly higher in immunized fish fed with diet supplemented with probiotic (vaccine +probiotic) than that in the immunized group fed with basal diet (vaccine group) while no significant differences in levels of hematological parameters, complements, total IgM, proteins, and the intestine lactic acid bacteria (LAB) were detected...
December 27, 2017: Probiotics and Antimicrobial Proteins
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