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https://www.readbyqxmd.com/read/27930412/zinc-deficiency-is-associated-with-poor-clinical-outcomes-in-patients-with-inflammatory-bowel-disease
#1
Shivi Siva, David T Rubin, George Gulotta, Kristin Wroblewski, Joel Pekow
BACKGROUND: Zinc plays a pivotal role in wound repair, tissue regeneration, and the immune response. Although zinc deficiency is common in patients with inflammatory bowel disease (IBD), the impact of low serum zinc levels on disease course is not known. METHODS: Patients enrolled in a prospectively collected IBD registry with at least 2 serum zinc measurements were included in the analysis. Using a logistic regression model, rates of IBD-related surgeries, IBD-related hospitalizations, and IBD-related complications were evaluated after a diagnosis of zinc deficiency (serum concentration <0...
December 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27930407/bowel-damage-in-crohn-s-disease-direct-comparison-of-ultrasonography-based-and-magnetic-resonance-based-lemann-index
#2
Antonio Rispo, Nicola Imperatore, Anna Testa, Pierpaolo Mainenti, Giovanni Domenico De Palma, Gaetano Luglio, Simone Maurea, Olga Maria Nardone, Nicola Caporaso, Fabiana Castiglione
BACKGROUND: The Lémann index (LI), calculated by magnetic resonance (MR) or computed tomography enterography in association with endoscopy, was developed to assess bowel damage (BD) in Crohn's disease (CD). Our aim was to investigate the concordance between ultrasonography-based Lèmann index (US-LI) and magnetic resonance-based Lèmann index (MR-LI). METHODS: We prospectively evaluated all consecutive patients with CD referred to our IBD Unit. All patients had undergone endoscopy, US and MR within 1 month...
December 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27930405/the-cost-of-crohn-s-disease-varied-health-care-expenditure-patterns-across-distinct-disease-trajectories
#3
Bhavana B Rao, Benjamin H Click, Ioannis E Koutroubakis, Claudia Ramos Rivers, Miguel Regueiro, Jason Swoger, Marc Schwartz, Jana Hashash, Arthur Barrie, Michael A Dunn, David G Binion
BACKGROUND: Patients with Crohn's disease (CD) encompass a heterogeneous disease spectrum, with variable health care utilization and expenditure patterns. Lémann Index (LI) is a metric that quantifies cumulative bowel damage and has shown utility in delineating distinct disease phenotypes. We aimed to characterize the financial burden from all medical care in CD cohort in relation to the variations in LI-based disease phenotypes. METHODS: CD patients with 5-year (y) follow-up from a prospective registry were included...
December 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27928830/systematic-review-with-meta-analysis-recurrence-of-crohn-s-disease-after-total-colectomy-with-permanent-ileostomy
#4
REVIEW
M Fumery, P S Dulai, P Meirick, A M Farrell, S Ramamoorthy, W J Sandborn, S Singh
BACKGROUND: Subtotal or total colectomy or proctocolectomy with permanent ileostomy (TC-PI) may be a treatment option for medically refractory colonic Crohn's disease (CD). AIM: To perform a systematic review and meta-analysis to evaluate the rate, risk factors and outcomes of CD recurrence after TC-PI. METHODS: In a systematic review ending 31 March 2016, we identified 18 cohort studies (1438 adults) who underwent TC-PI for colonic CD (median follow-up, 7...
December 8, 2016: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27926558/postoperative-venous-thromboembolism-in-patients-undergoing-abdominal-surgery-for-ibd-a-common-but-rarely-addressed-problem
#5
Matthew T Brady, Gregory J Patts, Amy Rosen, George Kasotakis, Jeffrey J Siracuse, Teviah Sachs, Angela Kuhnen, Hiroko Kunitake
BACKGROUND: Venous thromboembolism after abdominal surgery occurs in 2% to 3% of patients with Crohn's disease and ulcerative colitis. However, no evidence-based guidelines currently exist to guide postdischarge prophylactic anticoagulation. OBJECTIVE: We sought to determine the use of postoperative postdischarge venous thromboembolism chemical prophylaxis, 90-day venous thromboembolism rates, and factors associated with 90-day thromboembolic events in IBD patients following abdominal surgery...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27922024/improvements-in-the-long-term-outcome-of-crohn-s-disease-over-the-past-two-decades-and-the-relation-to-changes-in-medical-management-results-from-the-population-based-ibdsl-cohort
#6
Steven F G Jeuring, Tim R A van den Heuvel, Limmie Y L Liu, Maurice P Zeegers, Wim H Hameeteman, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Ad A M Masclee, Daisy M A E Jonkers, Marieke J Pierik
OBJECTIVES: Medical treatment options and strategies for Crohn's disease (CD) have changed over the past decades. To assess its impact, we studied the evolution of the long-term disease outcome in the Dutch Inflammatory Bowel Disease South Limburg (IBDSL) cohort. METHODS: In total, 1,162 CD patients were included. Three eras were distinguished: 1991-1998 (n=316), 1999-2005 (n=387), and 2006-2011 (n=459), and patients were followed until 2014. Medication exposure and the rates of hospitalization, surgery, and phenotype progression were estimated using Kaplan-Meier survival analyses and compared between eras by multivariable Cox regression models...
December 6, 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27916926/ulcerative-colitis-and-crohn-s-disease-are-associated-with-decreased-serum-selenium-concentrations-and-increased-cardiovascular-risk
#7
Teresa Castro Aguilar-Tablada, Miguel Navarro-Alarcón, Javier Quesada Granados, Cristina Samaniego Sánchez, José Ángel Rufián-Henares, Flor Nogueras-Lopez
The incidence of inflammatory bowel disease (IBD) and associated oxidative stress is increasing. The antioxidant mineral selenium (Se) was measured in serum samples from 106 IBD patients (53 with ulcerative colitis (UC) and 53 with Crohn's disease (CD)) and from 30 healthy controls. Serum Se concentrations were significantly lower in UC and CD patients than in healthy controls (p < 0.001) and significantly lower in CD patients than in UC patients (p = 0.006). Se concentrations in patients were significantly influenced by sex, body mass index (BMI), the inflammatory biomarker α-1-antitrypsin, surgery, medical treatment, the severity, extent, and form of the disease and the length of time since onset (p < 0...
December 1, 2016: Nutrients
https://www.readbyqxmd.com/read/27915373/risk-factors-associated-with-postoperative-morbidity-in-over-500-colovesical-fistula-patients-undergoing-colorectal-surgery-a-retrospective-cohort-study-from-acs-nsqip-database
#8
H Hande Aydinli, Cigdem Benlice, Gokhan Ozuner, Emre Gorgun, Maher A Abbas
PURPOSE: The aim of this study was to evaluate the impact of various factors on 30-day postoperative morbidity in patients who underwent colorectal surgery (CRS) for colovesical fistula (CVF) in the elective and emergency settings. METHODS: Patients who underwent CRS for CVF between 2005 and 2013 were identified from the American College of Surgeons National Surgical Quality Improvement Program database by using current procedural terminology codes. Demographics, perioperative, and operative factors were assessed and compared between two groups classified according to the presence or absence of postoperative complications...
December 3, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27914655/crohn-s-disease
#9
REVIEW
Joana Torres, Saurabh Mehandru, Jean-Frédéric Colombel, Laurent Peyrin-Biroulet
Crohn's disease is a chronic inflammatory disease of the gastrointestinal tract, with increasing incidence worldwide. Crohn's disease might result from a complex interplay between genetic susceptibility, environmental factors, and altered gut microbiota, leading to dysregulated innate and adaptive immune responses. The typical clinical scenario is a young patient presenting with abdominal pain, chronic diarrhoea, weight loss, and fatigue. Assessment of disease extent and of prognostic factors for complications is paramount to guide therapeutic decisions...
November 30, 2016: Lancet
https://www.readbyqxmd.com/read/27911976/demographic-and-clinical-characteristics-of-a-predominantly-hispanic-population-with-inflammatory-bowel-disease-on-the-us-mexico-border
#10
Antonio Mendoza Ladd, Yi Jia, Christine Yu, Sherif Elhanafi, Alok Dwivedi, Jiayang Liu, Giangqing Song, Mark Hall, Marc J Zuckerman
OBJECTIVES: Information regarding Hispanics with inflammatory bowel disease (IBD) is scarce. In this study we aimed to describe a predominantly Hispanic population with IBD in a city located along the US-Mexico border and to identify clinical or demographic differences between Hispanics and non-Hispanics. METHODS: Retrospective cohort analysis of patients with IBD between 2003 and 2013 at a tertiary care center. Information collected included age, sex, ethnicity, diagnosis, diagnosis status (new vs old), endoscopic extent of disease (EOD), extraintestinal manifestations, medical treatment, and surgeries performed...
December 2016: Southern Medical Journal
https://www.readbyqxmd.com/read/27893980/managing-crohn-s-disease-after-surgery-a-patient-guide
#11
(no author information available yet)
No abstract text is available yet for this article.
November 25, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27893544/visceral-adiposity-genetic-susceptibility-and-risk-of-complications-among-individuals-with-crohn-s-disease
#12
Kimberley W J Van Der Sloot, Amit D Joshi, Danielle R Bellavance, Katherine K Gilpin, Kathleen O Stewart, Paul Lochhead, John J Garber, Cosmas Giallourakis, Vijay Yajnik, Ashwin N Ananthakrishnan, Behrooz Z Alizadeh, Ramnik J Xavier, Hamed Khalili
INTRODUCTION: Adipose tissue in mesenteric fat plays a key role in systemic and luminal inflammation. However, little is known about the role of visceral adipose tissue (VAT) and its interaction with genetic predisposition in Crohn's disease (CD) progression. METHODS: Our study population included patients with CD enrolled in Prospective Registry in Inflammatory Bowel Disease Study at Massachusetts General Hospital (PRISM). VAT volume was measured from computed tomography using Aquarius 3D...
November 22, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27892896/c-reactive-protein-as-a-diagnostic-and-prognostic-factor-in-inflammatory-bowel-diseases
#13
Dorota Mańkowska-Wierzbicka, Jacek Karczewski, Barbara Poniedziałek, Małgorzata Grzymisławska, Rafał Staszewski, Aleksandra Królczyk, Agnieszka Dobrowolska, Marian Grzymisławski
AIM: The study aimed to evaluate high-sensitivity CRP (hsCRP) as a diagnostic and predictive marker in patients with inflammatory bowel disease (IBD). MATERIAL/METHODS: Medical history of 106 patients with IBD revealed hsCRP concentrations at diagnosis and during the follow-up period. RESULTS: The study showed that the majority of investigated patients had elevated hsCRP concentrations at diagnosis, although the mean concentration was much higher in the group of patients with Crohn's disease (CD) than the group with ulcerative colitis (UC) (P<0...
November 7, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27890312/variables-associated-with-loss-of-ileoanal-pouches-constructed-in-childhood
#14
Khaled Abdelaal, Bruce Jaffray
AIMS: To quantify the incidence of loss of an ileoanal pouch in children and to identify variables associated this event. METHODS: Logistic regression of possible explanatory variables: age, sex, indication for procto-colectomy, pre-operative continence status, use of immunosuppressive drugs, open or laparoscopic surgery, number of stages, anastomotic leak, operative complication excluding anastomotic leak, performance of revisional surgery, albumin concentration and platelet count at time of surgery, rank order in series...
November 13, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27887705/perceptions-on-the-surgical-treatment-of-inflammatory-bowel-disease-in-spain-results-of-a-national-survey
#15
Luis Sánchez-Guillén, Francisco Blanco-Antona, Mónica Millán-Scheiding
INTRODUCTION: The incidence of inflammatory bowel disease (IBD) is increasing in Spain but there is little information on the availability of multidisciplinary care. This study aims to assess surgeon's opinions on the current situation of surgery for IBD in Spain. METHODS: An electronic closed survey was sent to members of the Spanish Association of Surgeons (AEC) from January to March 2015. This was a 52-item anonymised questionnaire with questions about how the treatment of IBD patients is organized in each centre, the existence of specific units, the management strategy in IBD patients, and the opinion of colorectal, general and trainee surgeons about the surgical treatment of IBD in their centre and in Spain...
November 22, 2016: Cirugía Española
https://www.readbyqxmd.com/read/27885481/post-operative-recurrence-of-crohn-s-disease-after-definitive-stoma-an-underestimated-risk
#16
Dine Koriche, Corinne Gower-Rousseau, Charbel Chater, Alain Duhamel, Julia Salleron, Noémie Tavernier, Jean-Frédéric Colombel, Benjamin Pariente, Antoine Cortot, Philippe Zerbib
INTRODUCTION: Crohn's disease (CD) is a progressive inflammatory disease affecting the entire gastrointestinal tract. The need for a definitive stoma (DS) is considered as the ultimate phase of damage. It is often believed that the risk of further disease progression is small when a DS has been performed. AIMS: The goals of the study were to establish the rate of CD recurrence above the DS and to identify predictive factors of CD recurrence at the time of DS. METHODS: We retrospectively reviewed all medical records of consecutive CD patients having undergone DS between 1973 and 2010...
November 24, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27885389/mri-features-of-perianal-fistulas-is-there-a-difference-between-crohn-s-and-non-crohn-s-patients
#17
Irai S Oliveira, Aoife Kilcoyne, Melissa C Price, Mukesh Harisinghani
PURPOSE: Though perianal fistulas are commonly seen in patients with Crohn's disease, they can also be seen in patients without inflammatory bowel disease. The purpose of this study was to evaluate MR imaging differences of perianal fistulas in patients with and without Crohn's disease. METHODS: Our retrospective search from January 2012 to December 2015 of the Radiology database for perianal fistula yielded 207 patients. Only patients with dedicated MR fistula protocol studies were included, whereas patients with previous anal surgery or anastomosis, anorectal tumors, and equivocal findings that could not be definitely assessed as a fistula were excluded...
November 24, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27883259/the-association-between-intensified-medical-treatment-time-to-surgery-and-ileocolic-specimen-length-in-crohn-s-disease
#18
E Joline de Groof, Tjibbe J Gardenbroek, Christianne J Buskens, Pieter J Tanis, Cyriel Y Ponsioen, Geert R A M D'Haens, Willem A Bemelman
BACKGROUND: During the last decade, treatment protocols have changed for patients with ileocolic Crohn's disease. Anti-TNF has become part of standard medical treatment, usually in a step-up approach. The aim was to analyse if improved medical treatment has resulted in more limited ileocolic resections and a longer interval between diagnosis and surgery. METHODS: Patients undergoing ileocolic resection for Crohn's disease were included (1999-2014). Patient characteristics were compared to the results of a population based study (between 2004-2010) previously performed in the catchment area of the present tertiary referral centre...
November 24, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/27878619/an-open-prospective-study-evaluating-efficacy-and-safety-of-a-new-medical-device-for-rectal-application-of-activated-carbon-in-the-treatment-of-chronic-uncomplicated-perianal-fistulas
#19
Antoni Zawadzki, Louis Banka Johnson, Måns Bohe, Claes Johansson, Mats Ekelund, Ole Haagen Nielsen
PURPOSE: It has been proposed that biological/chemical substances in the intestine might play a role in the occurrence and deterioration of perianal fistulas. Elimination of such unidentified factors from the lower gastrointestinal tract might offer a new strategy for the management of anal fistulas. The aim of this study was to evaluate the clinical effects on non-Crohn's disease perianal fistula healing, and the safety and tolerability of a new medical device that applies high-purity, high-activity granular activated carbon locally into the rectum twice daily of patients with perianal fistulas without any concomitant medication...
November 23, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27875505/radiologic-predictors-of-surgery-in-newly-diagnosed-pediatric-crohn-disease-patients
#20
Damien Parker, Boaz Karmazyn, Steven J Steiner
OBJECTIVES: The aim of the present study was to assess whether small bowel imaging conducted at the time of diagnosis could be used as a predictor of small bowel surgical intervention in a population of pediatric patients with Crohn disease (CD). METHODS: A retrospective analysis of small bowel imaging within 30 days of diagnosis of pediatric CD was conducted. Patients were divided into 2 groups based on small bowel imaging: those with no or minor abnormalities (71%) and those with more extensive or obstructive abnormalities (29%)...
December 2016: Journal of Pediatric Gastroenterology and Nutrition
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