Josefina Gómez-Garduño, Renato León-Rodríguez, Radamés Alemón-Medina, Beatriz E Pérez-Guillé, Rosa E Soriano-Rosales, Ailema González-Ortiz, Juan L Chávez-Pacheco, Edelmira Solorio-López, Paola Fernandez-Pérez, Liliana Rivera-Espinosa
Phytochemicals (Pch) present in fruits, vegetables and other foods, are known to inhibit or induce drug metabolism and transport. An exhaustive search was performed in five databases covering from 2000 to 2021. Twenty-one compounds from plants were found to modulate CYP3A and/or P-gp activities and modified the pharmacokinetics and the therapeutic effect of 27 different drugs. Flavonols, flavanones, flavones, stilbenes, diferuloylmethanes, tannins, protoalkaloids, flavans, hyperforin and terpenes, reduce plasma concentration of cyclosporine, simvastatin, celiprolol, midazolam, saquinavir, buspirone, everolimus, nadolol, tamoxifen, alprazolam, verapamil, quazepam, digoxin, fexofenadine, theophylline, indinavir, clopidogrel...
July 2022: Dose-response: a Publication of International Hormesis Society