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Enrique Martínez-Carranza, Gabriel Y Ponce-Soto, Alma L Díaz-Pérez, Erasmo Cadenas, Valeria Souza, Jesús Campos-García
The Cuatro Ciénegas Basin (CCB) within the Chihuahuan Desert in México is an extremely oligotrophic oasis with negligible phosphorous levels, described as a hot spot of biodiversity, not only in stromatolites and microbial mats, but also in living forms in general. The microorganisms possess the capability to produce a wide variety of virulence factors, antibiotics, and quorum-sensing (QS) crosstalk signals such as non-ribosomal cyclodipeptides (CDPs) which enables them to colonize diverse ecological niches...
November 11, 2017: Extremophiles: Life Under Extreme Conditions
Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Junaid Habib Khan, Khalid Hussain, Naureen Shehzadi
Background: Numerous medications are known to be associated with the development of lower urinary tract symptoms (LUTS). One such medication group is calcium channel blockers (CCB). Objective: To critically examine the literature regarding the involvement of CCB in manifestation of LUTS in humans. Methods: A systematic literature search was conducted on PubMed, SciELO, Scopus, and OpenGrey databases to find all potentially relevant research studies before August 2016...
2017: BioMed Research International
Ambreen Aleem, Khalid Hussain Janbaz
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus species are famous for their traditional uses and very commonly used for their anti-spasmodic and anti-diarrheal activities. Cyperus niveus Retz. is used in local traditional system of medicine in Pakistan to treat various gastrointestinal ailments. AIM OF THE STUDY: The aim of the study was to validate the traditional uses and to provide the possible mechanisms for the medicinal use of Cyperus niveus Retz. in gastrointestinal ailments...
November 6, 2017: Journal of Ethnopharmacology
Xudong Liu, Lixing Tan, Ignatius T S Yu, Zilong Zhang, Claudie Chiu-Yi Wong, Cui Guo, Kin Fai Ho, Arthur P S Lau, Eng Kiong Yeoh, Albert Lee, Xiang Qian Lao
BACKGROUND: Household cleaning products are widely used by the public, but limited data have been obtained on whether their use induces allergic dermatitis in children. OBJECTIVE: This study investigated the association between exposure to household cleaning products and allergic dermatitis in primary-school children. METHODS: A prospective cohort study of Hong Kong primary-school children was conducted between 2012 and 2014. A baseline survey was administered to 1,812 students who did not have allergic dermatitis...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Nattapol Tammachote, Phonthakorn Panichkul, Supakit Kanitnate
BACKGROUND: Customized cutting block (CCB) was designed to ensure the accurate alignment of knee prostheses during total knee arthroplasty. Given the paucity of CCB efficacy data, we compare CCB with conventional cutting guide using a randomized controlled trial. METHODS: One hundred eight osteoarthritic knee patients underwent total knee arthroplasty by one experienced surgeon were randomized to receive CCB (n = 54) or conventional cutting instrument (CCI) surgery (n = 54)...
October 6, 2017: Journal of Arthroplasty
Francisco J Zaragoza, Marion Eichmann, Dirk Flühs, Wolfgang Sauerwein, Lorenzo Brualla
BACKGROUND: The distribution of the emitter substance in (106)Ru eye plaques is usually assumed to be homogeneous for treatment planning purposes. However, this distribution is never homogeneous, and it widely differs from plaque to plaque due to manufacturing factors. METHODS: By Monte Carlo simulation of radiation transport, we study the absorbed dose distribution obtained from the specific CCA1364 and CCB1256 (106)Ru plaques, whose actual emitter distributions were measured...
September 2017: Ocular Oncology and Pathology
Priscilla Van Dyke, Kelan L Thomas
BACKGROUND: This study evaluated the influence of concomitant calcium channel blocker (CCB) and antipsychotic (AP) therapy on efficacy measures in patients with schizophrenia. METHODS: Data from the Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia study were used to evaluate the effect of concomitant CCB therapy on the Clinical Global Impression-Severity (CGI-S) score, Positive and Negative Syndrome Scale (PANSS) score, and time to all-cause discontinuation of AP treatment...
November 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
Pei-Fang Sim, Go Furusawa, Aik-Hong Teh
AlyQ from Persicobacter sp. CCB-QB2 is an alginate lyase with three domains - a carbohydrate-binding domain modestly resembling family 16 carbohydrate-binding module (CBM16), a family 32 CBM (CBM32) domain, and an alginate lyase domain belonging to polysaccharide lyase family 7 (PL7). Although AlyQ can also act on polyguluronate (poly-G) and polymannuronate (poly-M), it is most active on alginate. Studies with truncated AlyQ showed that the CBM32 domain did not contribute to enhancing AlyQ's activity under the assayed conditions...
October 20, 2017: Scientific Reports
Ka-Kei Sam, Nyok-Sean Lau, Go Furusawa, Al-Ashraf Abdullah Amirul
Hahella sp. strain CCB-MM4 is a halophilic bacterium isolated from estuarine mangrove sediment. The genome sequence of Hahella sp. CCB-MM4 provides insights into exopolysaccharide biosynthesis and the lifestyle of the bacterium thriving in a saline mangrove environment.
October 19, 2017: Genome Announcements
Erik Lindeman, Lovisa Baer Eriksson, Martin Thorsson, Johanna Nordmark Grass
High dose insulin euglycemia therapy - an important addition to the treatment arsenal in severe toxic myocardial depression Fifty-nine patients who developed hemodynamic symptoms necessitating treatment with vasopressors or inotropes after poisoning with calcium channel blockers (CCB) and beta blockers (BB) between January 2010 and August 2016 were identified by a search of the Poisons Information Centre database. In-hospital circulatory arrest occurred in 16/59 (27 %) and the mortality rate was 7/59 (12 %)...
October 9, 2017: Läkartidningen
Valeria Palmieri, Christina Backes, Nicole Ludwig, Tobias Fehlmann, Fabian Kern, Eckart Meese, Andreas Keller
Web repositories for almost all 'omics' types have been generated-detailing the repertoire of representatives across different tissues or cell types. A logical next step is the combination of these valuable sources. With IMOTA (interactive multi omics tissue atlas), we developed a database that includes 23 725 relations between miRNAs and 23 tissues, 310 932 relations between mRNAs and the same tissues as well as 63 043 relations between proteins and the 23 tissues in Homo sapiens. IMOTA also contains data on tissue-specific interactions, e...
August 11, 2017: Nucleic Acids Research
Alessandra Bettiol, Ersilia Lucenteforte, Alfredo Vannacci, Niccolò Lombardi, Graziano Onder, Nera Agabiti, Cristiana Vitale, Gianluca Trifirò, Giovanni Corrao, Giuseppe Roberto, Alessandro Mugelli, Alessandro Chinellato
BACKGROUND AND OBJECTIVES: Antihypertensive treatment with calcium channel blockers (CCBs) is consolidated in clinical practice; however, different studies observed increased risks of acute events for short-acting CCBs. This study aimed to provide real-world evidence on risks of acute cardiovascular (CV) events, hospitalizations and mortality among users of different CCB classes in secondary CV prevention. METHODS: Three case-control studies were nested in a cohort of Italian elderly hypertensive CV-compromised CCBs users...
October 3, 2017: Clinical Drug Investigation
Gavin N Saari, W Casan Scott, Bryan W Brooks
As an urban water cycle is increasingly realized, aquatic systems are influenced by sewage and wastewater effluent discharges of variable quality. Such urbanization results in exposures of non-target aquatic organisms to medicines and other contaminants. In the present study, we performed a unique global hazard assessment of calcium channel blockers (CCB) in multiple environmental matrices. Effluent and freshwater observations were primarily from North America (62% and 76%, respectively) and Europe (21% and 10%, respectively) with limited-to-no information from rapidly urbanizing regions of developing countries in Asia-Pacific, South America, and Africa...
September 14, 2017: Chemosphere
Lina Ma, Rui Han, Li Li, Zhenzhen Li, Fei Sun, Lijun Diao, Zhe Tang
OBJECTIVE: This study aimed to explore the epidemiological characteristics of antihypertensive drug use by community residents in Beijing, China. METHODS: Based on well-established statistical sampling techniques such as cluster, stratification, and random selection, 2832, 1828, and 2277 elderly residents aged ≥60 years in Beijing in 2000, 2004, and 2007, respectively, were included. The trend in antihypertensive drug use by elderly patients with hypertension was analyzed...
September 21, 2017: Archives of Gerontology and Geriatrics
Oluseyi Adejumo, Enajite Okaka, Ikponmwosa Iyawe
BACKGROUND: The prevalence of hypertension and attendant cardiovascular disease burden is increasing globally. Auditing antihypertensive prescriptions and assessing patients with hypertension for blood pressure (BP) control are important steps on the path to reducing hypertension-related morbidity, mortality, and health expenditure. This study assessed the prescription pattern of antihypertensive medications and BP control among hypertensive outpatients at the University of Benin Teaching Hospital in Benin City, Nigeria...
June 2017: Malawi Medical Journal: the Journal of Medical Association of Malawi
Louise E Bartlett, Nicole Pratt, Elizabeth E Roughead
AIM: To compare persistence in people who initiate the combination of amlodipine and statin as a fixed dose combination (FDC) or separate pill combination (SePC), and assess the impact of prior medicine exposure on this outcome. METHOD: Prescription dispensing data from a national administrative dataset were used to identify patients initiating FDCs or SePCs of amlodipine and statin between April and September 2013. Each cohort was stratified according to dispensing of calcium channel blockers (CCB) or statins in the prior 12 months...
September 25, 2017: Current Medical Research and Opinion
Tsu Horng Moh, Go Furusawa, Abdullah Al-Ashraf Amirul
A novel, rod-shaped, Gram-stain-negative, halophilic and non-motile bacterium, designated CCB-MM1(T), was isolated from a sample of estuarine sediment collected from Matang Mangrove Forest, Malaysia. The cells possessed a rod-coccus cell cycle in association with growth phase and formed aggregates. Strain CCB-MM1(T) was both catalase and oxidase positive, and able to degrade starch. Optimum growth occurred at 30 °C and pH 7.0 in the presence of 2-3 % (w/v) NaCl. The 16S rRNA gene sequence of strain CCB-MM1(T) showed 98...
October 2017: International Journal of Systematic and Evolutionary Microbiology
Safaa H Hammoud, Amal G Omar, Assaad A Eid, Mahmoud M El-Mas
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the immunosuppressant drug cyclosporine (CSA) upregulates EDHF-dependent renal vasodilations through altering CYP4A/CYP2C signaling, and (ii) calcium channel blockers modulate the CSA/EDHF/CYP interaction. Rats were treated with CSA, verapamil, nifedipine, or their combinations for 7days...
November 1, 2017: Toxicology and Applied Pharmacology
Chen Tan, Cheng Cui, Yi Xiang, Xianhong Ge, Zaiyun Li
We report the development and characterization of Brassica oleracea - nigra monosomic alien addition lines (MAALs) to dissect the Brassica B genome. Brassica nigra (2n = 16, BB) represents the diploid Brassica B genome which carries many useful genes and traits for breeding but received limited studies. To dissect the B genome from B. nigra, the triploid F1 hybrid (2n = 26, CCB) obtained previously from the cross B. oleracea var. alboglabra (2n = 18, CC) × B. nigra was used as the maternal parent and backcrossed successively to parental B...
December 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Gyu Chul Oh, Hae-Young Lee, Wook Jin Chung, Ho-Joong Youn, Eun-Joo Cho, Ki-Chul Sung, Shung Chull Chae, Byung-Su Yoo, Chang Gyu Park, Soon Jun Hong, Young Kwon Kim, Taek-Jong Hong, Dong-Ju Choi, Min Su Hyun, Jong Won Ha, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Soon-Gil Kim, Jinho Shin, Sungha Park, Il-Suk Sohn, Chong-Jin Kim
BACKGROUND: Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only half of them receive adequate treatment. Current guidelines on antihypertensive treatment recommend combination therapy for patients not responding to monotherapy, but as the number of pills increase, patient compliance tends to decrease. As a result, fixed-dose combination drugs with different antihypertensive agents have been developed and widely used in recent years...
2017: Clinical Hypertension
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