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https://www.readbyqxmd.com/read/29326507/effect-of-calcium-channel-blockers-on-gingival-tissues-in-hypertensive-patients-in-lagos-nigeria-a-pilot-study
#1
Kehinde Adesola Umeizudike, Adetokunbo B Olawuyi, Theophilus I Umeizudike, Akinsanya D Olusegun-Joseph, Babawale T Bello
Background: Long-term treatment of common chronic cardiac conditions such as hypertension with calcium channel blockers (CCBs) has long been associated with gingival hyperplasia. This oral side effect may affect esthetics and function, yet often overlooked and therefore underreported among Nigerians. Aim: This study aimed to determine the association of CCBs with gingival overgrowth (GO) in hypertensive patients. Methods: This was a hospital-based, case-control study conducted among 116 hypertensive patients (58 CCB and 58 non-CCB age-matched controls) attending the medical outpatient clinic of a tertiary health institution in Lagos, Nigeria...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29309048/early-b-cell-changes-predict-autoimmunity-following-combination-immune-checkpoint-blockade
#2
Rituparna Das, Noffar Bar, Michelle Ferreira, Aaron M Newman, Lin Zhang, Jithendra Kini Bailur, Antonella Bacchiocchi, Harriet Kluger, Wei Wei, Ruth Halaban, Mario Sznol, Madhav V Dhodapkar, Kavita M Dhodapkar
Combination checkpoint blockade (CCB) targeting inhibitory CTLA4 and PD1 receptors holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major obstacle for the optimal application of CCB in cancer. Here, we analyzed B cell changes in patients with melanoma following treatment with either anti-CTLA4 or anti-PD1, or in combination. CCB therapy led to changes in circulating B cells that were detectable after the first cycle of therapy and characterized by a decline in circulating B cells and an increase in CD21lo B cells and plasmablasts...
January 8, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29294833/animal-maltreatment-as-a-risk-marker-of-more-frequent-and-severe-forms-of-intimate-partner-violence
#3
Betty Jo Barrett, Amy Fitzgerald, Rochelle Stevenson, Chi Ho Cheung
Although there is a growing body of literature documenting the co-occurrence of animal abuse and intimate partner violence (IPV), only a few studies have examined the relationship between animal maltreatment, types of IPV, and abuse severity. The results of those studies have been inconclusive and in some cases even contradictory. The current study contributes new findings to that specific segment of the literature and sheds some light on the inconsistent findings in previous studies. Data were gathered from 86 abused women receiving services from domestic violence shelters across Canada via a structured survey about pet abuse and the level and types of IPV perpetrated by abusive partners...
July 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29281000/a-high-resolution-map-of-the-human-small-non-coding-transcriptome
#4
Tobias Fehlmann, Christina Backes, Julia Alles, Ulrike Fischer, Martin Hart, Fabian Kern, Hilde Langseth, Trine Rounge, Sinan Ugur Umu, Mustafa Kahraman, Thomas Laufer, Jan Haas, Cord Staehler, Nicole Ludwig, Matthias Hübenthal, Benjamin Meder, Andre Franke, Hans-Peter Lenhof, Eckart Meese, Andreas Keller
Motivation: While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are represented in the human genome. Results: In this study we analyzed 303 billion sequencing reads from nearly 25,000 data sets to answer this question. We determined that 0.8% of the human genome are reliably covered by 874,123 regions with an average length of 31nt. On the basis of these regions, we found that among the known small non-coding RNA classes, microRNAs were the most prevalent...
December 21, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29259553/indication-of-cognitive-change-and-associated-risk-factor-after-thoracic-surgery-in-the-elderly-a-pilot-study
#5
Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima
Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more likely to exhibit symptoms of POCD, the incidence is increasing as the population receiving surgery is aging. Methods: Cognitive function was measured for all subjects (n = 12) before and after surgery using three different cognitive tests: Mini-Mental Status Exam-Japanese (MMSE-J), Frontal Assessment Battery (FAB), and a computerized Cogstate Brief Battery (CBB)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29240784/effects-of-calcium-channel-blockers-comparing-to-angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-patients-with-hypertension-and-chronic-kidney-disease-stage-3-to-5-and-dialysis-a-systematic-review-and-meta-analysis
#6
Yen-Chung Lin, Jheng-Wei Lin, Mai-Szu Wu, Kuan-Chou Chen, Chiung-Chi Peng, Yi-No Kang
BACKGROUND: Calcium channel blocker (CCB) or two renin angiotensin aldosterone system blockades (RAAS), angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), are major potent and prevalently used as initial antihypertensive agents for mild to moderate hypertension, but no uniform agreement as to which antihypertensive drugs should be given for initial therapy, especially among chronic kidney disease (CKD) patients. DESIGN: A systematic review and meta-analysis comparing CCBs and the two RAAS blockades for hypertensive patients with CKD stage 3 to 5D...
2017: PloS One
https://www.readbyqxmd.com/read/29237099/calcium-channel-blockers-for-primary-and-secondary-raynaud-s-phenomenon
#7
REVIEW
Fadumo Rirash, Paul C Tingey, Sarah E Harding, Lara J Maxwell, Elizabeth Tanjong Ghogomu, George A Wells, Peter Tugwell, Janet Pope
BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required...
December 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29236851/tannic-extract-potential-as-natural-wood-preservative-of-acacia-mearnsii
#8
Amanda G DA Silveira, Elio J Santini, Stela M Kulczynski, Rômulo Trevisan, Arci D Wastowski, Darci A Gatto
High toxicity of the preservatives most frequently used in wood treatment and the resulting risks of handling pose a threat to small producers and to the environment. In an attempt to mitigate these problems, the present study was conducted with the objective of evaluating the preservative effect of tannic extract on biodeterioration of Acacia mearnsii wood. For this purpose, untreated and preserved specimens, some with tannin extract and some with a preservative mixture based on CCB (Chromated Copper Borate), were submitted to accelerated rotting trials with the fungus that causes white rot (Pycnoporus sanguineus) for 16 weeks...
December 7, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29218625/diuretic-or-beta-blocker-for-hypertensive-patients-already-receiving-acei-arb-and-calcium-channel-blocker
#9
Min-Shan Tsai, Chao-Hsiun Tang, Chia-Ying Lin, Po-Ya Chuang, Nai-Chuan Chen, Chien-Hua Huang, Wei-Tien Chang, Tzung-Dau Wang, Ping-Hsun Yu, Wen-Jone Chen
BACKGROUND: In patients already receiving combination of angiotensin-converting enzyme inhibitor (ACEI)/angiotensin receptor blocker (ARB) and calcium channel blocker (CCB), whether the choice of additional diuretic or beta-blocker affects the cardiovascular and cerebrovascular outcomes remains unclear. METHODS: A total of 13,551 patients who were concurrently receiving three anti-hypertensive agents of different classes through outpatient clinics during 2004-2006 were identified from the National Health Insurance Research Database of Taiwan...
December 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29201023/a-marine-actinomycete-rescues-caenorhabditis-elegans-from-pseudomonas-aeruginosa-infection-through-restitution-of-lysozyme-7
#10
Siti N Fatin, Tan Boon-Khai, Alexander Chong Shu-Chien, Melati Khairuddean, Amirul Al-Ashraf Abdullah
The resistance of Pseudomonas aeruginosa to conventional antimicrobial treatment is a major scourge in healthcare. Therefore, it is crucial that novel potent anti-infectives are discovered. The aim of the present study is to screen marine actinomycetes for chemical entities capable of overcoming P. aeruginosa infection through mechanisms involving anti-virulence or host immunity activities. A total of 18 actinomycetes isolates were sampled from marine sediment of Songsong Island, Kedah, Malaysia. Upon confirming that the methanolic crude extract of these isolates do not display direct bactericidal activities, they were tested for capacity to rescue Caenorhabditis elegans infected with P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29180927/comparative-efficacy-of-epigallocatechin-3-gallate-against-h2o2-induced-ros-in-cervical-cancer-biopsies-and-hela-cell-lines
#11
Sohail Hussain
Aim of the study: Antioxidants play an important role in maintaining physiological homeostasis. Recent literature emphasises the potential therapeutic effects of natural antioxidants that play anti-inflammatory and antioxidant effects applicable in preventing oxidative stress-induced injury, which characterises their pathogenesis. The goal of this study was to evaluate the protective role of EGCG on the HeLa cell line and cancerous cells. Material and methods: The HeLa cell line and cervical cancer biopsies (CCB) were treated with varying doses of antioxidants to determine their effects...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29172244/comparative-study-of-amlodipine-versus-cilnidipine-for-the-prevention-of-hepatic-ischemia-reperfusion-injury-in-rat-model
#12
Abdel-Motaal M Fouda, Amany Ragab Youssef, Osama Sharaf Eldin
Ca(2+) signaling plays crucial role in ischemia and reperfusion (I/R) injury. Although blockade of L-type Ca(2+) channels by amlodipine (AML) has been shown to suppress hepatic I/R injury in several animal models, information is still needed regarding the hepatoprotective effects of the dual L/N-type CCB, cilnidipine (CIL). We examined the effect of pretreatment with AML or CIL (100 μg/kg i.p.) 45 min before induction of 60 min of liver ischemia followed by reperfusion, on oxidative stress markers, liver enzymes, serum tumor necrosis factor (TNF)-α, interleukin (IL)-1β, apoptosis markers, and nuclear factor KB (NF-κB) after 6 and 24 h of hepatic reperfusion...
November 24, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29152493/a-pilot-study-evaluating-biomarker-development-for-drug-induced-chronic-eczematous-eruptions-of-aging-individuals
#13
Erika Mae Summers, Nicholas Ray Blickenstaff, Garrett Curtis Coman, Thomas Bernd Martins, Harry Raymond Hill, Richard Dennis Sontheimer
Background: Identifying the drug(s) responsible for drug-induced chronic eczematous eruptions of aging individuals (CEEA) is a clinical challenge in patients on multiple medications. Reliable in vitro testing methods and biomarkers are needed to identify the causative agent and allow simultaneous assessment of T-cell responses to multiple drugs being taken concurrently. This study examined the feasibility of using in vitro, drug-specific T cell activation responses as a biomarker for drug-induced CEEA...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29128968/involvement-of-cyclodipeptides-in-the-competition-of-bacterial-communities-in-the-oligotrophic-churince-aquatic-system-of-cuatro-ci%C3%A3-negas-basin-dominated-by-gammaproteobacteria
#14
Enrique Martínez-Carranza, Gabriel Y Ponce-Soto, Alma L Díaz-Pérez, Erasmo Cadenas, Valeria Souza, Jesús Campos-García
The Cuatro Ciénegas Basin (CCB) within the Chihuahuan Desert in México is an extremely oligotrophic oasis with negligible phosphorous levels, described as a hot spot of biodiversity, not only in stromatolites and microbial mats, but also in living forms in general. The microorganisms possess the capability to produce a wide variety of virulence factors, antibiotics, and quorum-sensing (QS) crosstalk signals such as non-ribosomal cyclodipeptides (CDPs) which enables them to colonize diverse ecological niches...
November 11, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29124064/effect-of-calcium-channel-blockers-on-lower-urinary-tract-symptoms-a-systematic-review
#15
REVIEW
Muhammad Salman, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Junaid Habib Khan, Khalid Hussain, Naureen Shehzadi
Background: Numerous medications are known to be associated with the development of lower urinary tract symptoms (LUTS). One such medication group is calcium channel blockers (CCB). Objective: To critically examine the literature regarding the involvement of CCB in manifestation of LUTS in humans. Methods: A systematic literature search was conducted on PubMed, SciELO, Scopus, and OpenGrey databases to find all potentially relevant research studies before August 2016...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29122673/involvement-of-dual-mechanisms-of-anti-muscarinic-and-ca-antagonistic-activities-to-validate-the-folkloric-uses-of-cyperus-niveus-retz-in-multiple-gastrointestinal-ailments
#16
Ambreen Aleem, Khalid Hussain Janbaz
ETHNOPHARMACOLOGICAL RELEVANCE: Cyperus species are famous for their traditional uses and very commonly used for their anti-spasmodic and anti-diarrheal activities. Cyperus niveus Retz. is used in local traditional system of medicine in Pakistan to treat various gastrointestinal ailments. AIM OF THE STUDY: The aim of the study was to validate the traditional uses and to provide the possible mechanisms for the medicinal use of Cyperus niveus Retz. in gastrointestinal ailments...
November 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29114947/household-cleaning-products-and-the-risk-of-allergic-dermatitis-a-prospective-cohort-study-with-primary-school-children
#17
Xudong Liu, Lixing Tan, Ignatius T S Yu, Zilong Zhang, Claudie Chiu-Yi Wong, Cui Guo, Kin Fai Ho, Arthur P S Lau, Eng Kiong Yeoh, Albert Lee, Xiang Qian Lao
BACKGROUND: Household cleaning products are widely used by the public, but limited data have been obtained on whether their use induces allergic dermatitis in children. OBJECTIVE: This study investigated the association between exposure to household cleaning products and allergic dermatitis in primary-school children. METHODS: A prospective cohort study of Hong Kong primary-school children was conducted between 2012 and 2014. A baseline survey was administered to 1,812 students who did not have allergic dermatitis...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29108794/comparison-of-customized-cutting-block-and-conventional-cutting-instrument-in-total-knee-arthroplasty-a-randomized-controlled-trial
#18
Nattapol Tammachote, Phonthakorn Panichkul, Supakit Kanitnate
BACKGROUND: Customized cutting block (CCB) was designed to ensure the accurate alignment of knee prostheses during total knee arthroplasty. Given the paucity of CCB efficacy data, we compare CCB with conventional cutting guide using a randomized controlled trial. METHODS: One hundred eight osteoarthritic knee patients underwent total knee arthroplasty by one experienced surgeon were randomized to receive CCB (n = 54) or conventional cutting instrument (CCI) surgery (n = 54)...
October 6, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29071271/monte-carlo-estimation-of-absorbed-dose-distributions-obtained-from-heterogeneous-106-ru-eye-plaques
#19
Francisco J Zaragoza, Marion Eichmann, Dirk Flühs, Wolfgang Sauerwein, Lorenzo Brualla
BACKGROUND: The distribution of the emitter substance in (106)Ru eye plaques is usually assumed to be homogeneous for treatment planning purposes. However, this distribution is never homogeneous, and it widely differs from plaque to plaque due to manufacturing factors. METHODS: By Monte Carlo simulation of radiation transport, we study the absorbed dose distribution obtained from the specific CCA1364 and CCB1256 (106)Ru plaques, whose actual emitter distributions were measured...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29069114/concomitant-calcium-channel-blocker-and-antipsychotic-therapy-in-patients-with-schizophrenia-efficacy-analysis-of-the-catie-sz-phase-1-data
#20
Priscilla Van Dyke, Kelan L Thomas
BACKGROUND: This study evaluated the influence of concomitant calcium channel blocker (CCB) and antipsychotic (AP) therapy on efficacy measures in patients with schizophrenia. METHODS: Data from the Clinical Antipsychotic Trials of Intervention Effectiveness in Schizophrenia study were used to evaluate the effect of concomitant CCB therapy on the Clinical Global Impression-Severity (CGI-S) score, Positive and Negative Syndrome Scale (PANSS) score, and time to all-cause discontinuation of AP treatment...
November 1, 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
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