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https://www.readbyqxmd.com/read/28905698/microbulbifer-aggregans-sp-nov-isolated-from-estuarine-sediment-from-a-mangrove-forest
#1
Tsu Horng Moh, Go Furusawa, Abdullah Al-Ashraf Amirul
A novel, rod-shaped, Gram-stain-negative, halophilic and non-motile bacterium, designated CCB-MM1T, was isolated from a sample of estuarine sediment collected from Matang Mangrove Forest, Malaysia. The cells possessed a rod-coccus cell cycle in association with growth phase and formed aggregates. Strain CCB-MM1T was both catalase and oxidase positive, and able to degrade starch. Optimum growth occurred at 30 °C and pH 7.0 in the presence of 2-3 % (w/v) NaCl. The 16S rRNA gene sequence of strain CCB-MM1T showed 98...
September 14, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28899749/cyp4a-cyp2c-modulation-of-the-interaction-of-calcium-channel-blockers-with-cyclosporine-on-edhf-mediated-renal-vasodilations-in-rats
#2
Safaa H Hammoud, Amal G Omar, Assaad A Eid, Mahmoud M El-Mas
The endothelium-derived hyperpolarizing factor (EDHF) serves as a back-up mechanism that compensates for reduced nitric oxide (NO)/prostanoids bioavailability. Here we investigated whether (i) under conditions of vascular endothelium dysfunction, the immunosuppressant drug cyclosporine (CSA) upregulates EDHF-dependent renal vasodilations through altering CYP4A/CYP2C signaling, and (ii) calcium channel blockers modulate the CSA/EDHF/CYP interaction. Rats were treated with CSA, verapamil, nifedipine, or their combinations for 7days...
September 9, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28884205/development-of-brassica-oleracea-nigra-monosomic-alien-addition-lines-genotypic-cytological-and-morphological-analyses
#3
Chen Tan, Cheng Cui, Yi Xiang, Xianhong Ge, Zaiyun Li
We report the development and characterization of Brassica oleracea - nigra monosomic alien addition lines (MAALs) to dissect the Brassica B genome. Brassica nigra (2n = 16, BB) represents the diploid Brassica B genome which carries many useful genes and traits for breeding but received limited studies. To dissect the B genome from B. nigra, the triploid F1 hybrid (2n = 26, CCB) obtained previously from the cross B. oleracea var. alboglabra (2n = 18, CC) × B. nigra was used as the maternal parent and backcrossed successively to parental B...
September 7, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28879040/comparison-of-effects-between-calcium-channel-blocker-and-diuretics-in-combination-with-angiotensin-ii-receptor-blocker-on-24-h-central-blood-pressure-and-vascular-hemodynamic-parameters-in-hypertensive-patients-study-design-for-a-multicenter-double-blinded
#4
Gyu Chul Oh, Hae-Young Lee, Wook Jin Chung, Ho-Joong Youn, Eun-Joo Cho, Ki-Chul Sung, Shung Chull Chae, Byung-Su Yoo, Chang Gyu Park, Soon Jun Hong, Young Kwon Kim, Taek-Jong Hong, Dong-Ju Choi, Min Su Hyun, Jong Won Ha, Young Jo Kim, Youngkeun Ahn, Myeong Chan Cho, Soon-Gil Kim, Jinho Shin, Sungha Park, Il-Suk Sohn, Chong-Jin Kim
BACKGROUND: Hypertension is a risk factor for coronary heart disease and stroke, and is one of the leading causes of death. Although over a billion people are affected worldwide, only half of them receive adequate treatment. Current guidelines on antihypertensive treatment recommend combination therapy for patients not responding to monotherapy, but as the number of pills increase, patient compliance tends to decrease. As a result, fixed-dose combination drugs with different antihypertensive agents have been developed and widely used in recent years...
2017: Clinical Hypertension
https://www.readbyqxmd.com/read/28866282/calcium-channel-blockers-and-breast-cancer-incidence-an-updated-systematic-review-and-meta-analysis-of-the-evidence
#5
REVIEW
Cameron M Wright, Rachael E Moorin, Enayet K Chowdhury, Bruno H Stricker, Christopher M Reid, Christobel M Saunders, Jeffery D Hughes
Controversy exists regarding the potential association between taking calcium channel blockers (CCBs) and the development of breast cancer. As a positive association would have important public health implications due to the widespread use of CCBs, this study aimed to incorporate new evidence to determine whether an association is likely to exist. We searched MEDLINE, EMBASE and the Cochrane Library to 28 June 2016 for relevant literature. References and citing articles were checked and authors contacted as necessary...
September 1, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28860225/is-cardiovascular-risk-reduction-therapy-effective-in-south-asian-chinese-and-other-patients-with-diabetes-a-population-based-cohort-study-from-canada
#6
Calvin H Ke, Steve Morgan, Kate Smolina, Danijela Gasevic, Hong Qian, Nadia A Khan
OBJECTIVES: Guidelines recommend ACE inhibitors (ACEi), angiotensin receptor blockers (ARBs), calcium channel blockers (CCBs) and diuretics in all patients with diabetes mellitus. However, the effectiveness of these agents in South Asian and Chinese populations is unknown. We sought to determine whether ACEi, ARB, CCB and diuretics are associated with reduced mortality in South Asian, Chinese and other patients with diabetes. DESIGN: Population-based cohort study using administrative health databases...
August 31, 2017: BMJ Open
https://www.readbyqxmd.com/read/28853232/rate-control-with-beta-blockers-versus-calcium-channel-blockers-in-the-emergency-setting-predictors-of-medication-class-choice-and-associated-hospitalization
#7
Clare L Atzema, Peter C Austin
OBJECTIVES: Rate-control is an important component of the management of patients with atrial fibrillation (AF). Previous studies of emergency department (ED) rate-control have been limited by relatively small sample sizes. We examined the use of beta-blockers (BB) versus non-dihydropyridine calcium channel blockers (CCB) in ED patients from 24 sites, and the associated hospital admission rates. METHODS: In this pre-planned sub-study, we examined chart data on AF patients who visited one of 24 hospital EDs in Ontario, Canada, between April 2008 and March 2009...
August 29, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28815395/identification-of-a-novel-envelope-protein-encoded-by-orf-136-from-cyprinid-herpesvirus-3
#8
Shucheng Zheng, Yingying Li, Qing Wang, Jiexing Wu, Yingying Wang, Weiwei Zeng, Sven M Bergmann, Yan Ren, Cunbin Shi
Cyprinid herpesvirus 3 (CyHV-3) is the pathogenic agent of koi herpesvirus disease (KHVD) afflicting common carp and koi (Cyprinus carpio L.) populations globally. As described previously, proteomic analyses of purified CyHV-3 particles have shown that at least 46 structural proteins are incorporated into CyHV-3 virions; among these ORF136 may encode a putative envelope protein. In this study, Western blotting analysis showed that a specific band with the predicted molecular weight of 17 kDa was detected both in purified virions and envelope components using a rabbit anti-ORF136 polyclonal antibody...
August 16, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28791379/felodipine-inhibits-ox-ldl-induced-reactive-oxygen-species-production-and-inflammation-in-human-umbilical-vein-endothelial-cells
#9
Jie Qi, Jian-Bao Zheng, Wen-Ting Ai, Xiao-Wei Yao, Lei Liang, Gong Cheng, Xi-Ling Shou, Chao-Feng Sun
Oxidative stress and inflammation are involved in the pathogenesis of atherosclerosis. Calcium channel blockers (CCBs) inhibit the development of atherosclerosis, although the underlying molecular basis has not been completely elucidated. The present study was designed to investigate the effects of felodipine, a CCB, on inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs) and to examine the underlying mechanisms of action. Oxidized low‑density lipoprotein (ox‑LDL) was used to induce an inflammatory response in HUVECs...
October 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28777899/effect-of-hyperbaric-oxygen-therapy-on-blood-pressure-in-patients-undergoing-treatment
#10
Marvin Heyboer Rd, Susan M Wojcik, Garrett Smith, William Santiago
INTRODUCTION: Hyperbaric oxygen (HBO₂) therapy is generally safe and well tolerated. However, known side effects do exist. Elevation in the blood pressure of patients undergoing HBO₂ therapy is a less defined potential side effect. We sought to better quantify effects of HBO₂ on blood pressure (BP) in patients undergoing HBO₂. METHODS: A retrospective chart review was performed on quality assurance data captured on all patients undergoing HBO₂ between March 2012 and October 2015 at a large tertiary referral university hospital hyperbaric center...
March 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28765339/use-of-calcium-channel-blockers-and-breast-cancer-risk-in-the-women-s-health-initiative
#11
Theodore M Brasky, Jessica L Krok-Schoen, Jingmin Liu, Rowan T Chlebowski, Jo L Freudenheim, Sayeh Lavasani, Karen L Margolis, Lihong Qi, Kerryn W Reding, Peter G Shields, Michael S Simon, Jean Wactawski-Wende, Ange Wang, Catherine Womack, JoAnn E Manson
Background: Use of calcium channel blockers (CCBs) has been associated with increased risk of breast cancer in some, but not all, studies. Differences in reported associations from prior studies may be due, in part, to inadequate control of confounding factors.Methods: Participants were 28,561 postmenopausal women from the Women's Health Initiative who reported use of either CCBs or other antihypertensive medications (AHMs) at baseline; 1,402 incident breast cancer cases were diagnosed during 12 years of follow-up...
August 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28760424/anthocyanins-in-chokeberry-and-purple-maize-attenuate-diet-induced-metabolic-syndrome-in-rats
#12
Maharshi Bhaswant, Siti Raihanah Shafie, Michael L Mathai, Peter Mouatt, Lindsay Brown
OBJECTIVE: Increased consumption of fruits and vegetables as functional foods leads to the reduction of signs of metabolic syndrome. The aim of this study was to measure and compare cardiovascular, liver, and metabolic parameters following chronic administration of the same dose of anthocyanins either from chokeberry (CB) or purple maize (PM) in rats with diet-induced metabolic syndrome. METHODS: Male Wistar rats were fed a maize starch (C) or high-carbohydrate, high-fat diet (H) and divided into six groups for 16 wk...
September 2017: Nutrition
https://www.readbyqxmd.com/read/28756724/medical-expulsive-therapy-in-urolithiasis-a-mixed-treatment-comparison-network-meta-analysis-of-randomized-controlled-clinical-trials
#13
Kannan Sridharan, Gowri Sivaramakrishnan
BACKGROUND: Medical expulsive therapy (MET) using alpha blockers, calcium channel blockers (CCB), phosphodiesterase inhibitors (PDEI) and spasmolytics have been shown to be effective in clinical trials on urolithiasis. The present study is a network meta-analysis comparing the above mentioned drug classes. RESEARCH DESIGN AND METHODS: Electronic databases were searched for randomized controlled trials comparing the above mentioned drug classes in patients with urolithiasis using appropriate search strategy...
October 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28755451/comparative-effectiveness-of-antihypertensive-drugs-in-nondiabetic-patients-with-hypertension-a-population-based-study
#14
Marina Amaral de Ávila Machado, Cristiano Soares de Moura, Yishu Wang, Coraline Danieli, Michal Abrahamowicz, Sasha Bernatsky, Hassan Behlouli, Louise Pilote
The authors compared the effectiveness of thiazide diuretic (TD), angiotensin-converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), and calcium channel blocker (CCB) monotherapies for the treatment of nondiabetic hypertension using MarketScan Databases 2010-2014. Multivariable Cox regression models assessed whether the addition of a new antihypertensive drug, treatment discontinuation, or switch and major cardiovascular or cerebrovascular events varied across groups. A total of 565 009 patients started monotherapy with ACEIs (43...
July 29, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28752275/the-impact-of-antihypertensive-medications-on-bone-mineral-density-and-fracture-risk
#15
REVIEW
Joshua I Barzilay, Barry R Davis, Sara L Pressel, Alokananda Ghosh, Rachel Puttnam, Karen L Margolis, Paul K Whelton
PURPOSE OF REVIEW: This review summarizes the impact of thiazide diuretics on fracture risk in older hypertensive individuals. RECENT FINDINGS: We performed a post hoc evaluation of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, a randomized, prospective, double blind hypertension study comparing a thiazide-like diuretic, a calcium channel blocker (CCB), and an angiotensin converting enzyme inhibitor (ACEi). We examined the risk of hip and pelvic fractures during the in-trial period (n = 22,180 participants; mean 4...
September 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28704130/scleral-thinning-documented-by-ultrasound-biomicroscopy-after-plaque-therapy-for-anterior-ciliary-melanoma
#16
B Kuzmanović Elabjer, M Bušić, D Miletić, M Bjeloš, N Vukojević, D Bosnar
PURPOSE: To evaluate, by ultrasound biomicroscopy (UBM), changes in scleral thickness after ruthenium-106 CCB and CCC plaque (Eckert & Ziegler BE-BIG GmbH, Berlin, Germany) therapy for anterior ciliary melanoma. METHODS: Eleven patients with anterior ciliary melanoma underwent ruthenium-106 CCB and CCC plaque radiation with a radiation dose at the tumor apex of 80-100 Gy. UBM measurements performed prior to and after treatment were as follows: the largest prominence of the tumor perpendicular to the sclera and scleral thickness at scleral spur, 1...
July 13, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/28688059/a-case-of-severe-refractory-hypotension-after-amlodipine-overdose
#17
Melissa Chudow, Kevin Ferguson
Calcium channel blockers (CCBs) are responsible for a substantial portion of the mortality associated with cardiovascular medication overdose cases. Amlodipine, a dihydropyridine CCB, can cause prolonged hypotension in overdose. This report describes a severe amlodipine overdose case that was refractory to multiple therapeutic approaches. A 53-year-old male presented after ingesting eighty 10 mg amlodipine tablets in a suicide attempt. The patient was initially managed with calcium boluses, glucagon, multiple vasoactive agents, lipid emulsion infusions and hyperinsulinemic euglycemic therapy...
July 7, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28674077/physicians-are-more-likely-than-non-physicians-to-use-brand-name-drugs-to-treat-their-chronic-conditions
#18
REVIEW
Mariana Carrera, Niels Skipper
BACKGROUND: Little is known about the treatments physicians choose for themselves compared with how they treat their patients. We determine if physicians prescribe different treatments to patients than to themselves. METHODS: Population-based cohort study from 2004 to 2012 examining prescription claims of all Danish primary care physicians (PCP; n=3088) and all other Danish adults (n=2 334 590) who received a first-time prescription from a PCP for a statin (n=455 586), calcium channel blocker (CCB, n=330 369), serotonin-norepinephrine/selective serotonin reuptake inhibitors (SN/SSRIs, n=423 740), proton pump inhibitor (PPI, n=671 965) or antihistamine (n=456 018)...
July 3, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28672198/phosphate-recovery-from-liquid-fraction-of-anaerobic-digestate-using-four-slow-pyrolyzed-biochars-dynamics-of-adsorption-desorption-and-regeneration
#19
Simon Kizito, Hongzhen Luo, Shubiao Wu, Zeeshan Ajmal, Tao Lv, Renjie Dong
Four slow pyrolyzed biochars produced from wood (WDB), corncobs (CCB), rice husks (RHB) and sawdust (SDB) were evaluated for adsorption, desorption and regeneration of phosphate (PO4(3-)-P) from anaerobically digested liquid swine manure. The PO4(3-)-P adsorption capacity increased followed by initial concentrations increasing. Maximum PO4(3-)-P adsorptions at initial 150 mg/L of PO4(3-)-P (highest load) were average of 7.67, 6.43, 5.73 and 5.41 mg/g for WDB, CCB, RHB and SDB, respectively. Pseudo second order kinetics model could best fit PO4(3-)-P adsorption, which indicated the chemisorption via precipitation was the main mechanism for PO4(3-)-P removal...
June 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28671151/a-profile-of-adverse-effects-of-antihypertensive-medicines-in-a-tertiary-care-clinic-in-nigeria
#20
Abimbola O Olowofela, Ambrose O Isah
BACKGROUND: There has been a dearth of comprehensive data on the profile of adverse reactions to antihypertensive medicines in the Nigerian setting despite increased use. OBJECTIVE: This study was aimed to characterize the adverse reactions experienced in the homogenously black African population. METHODS: The study was carried out at the University of Benin Teaching Hospital, Benin City, Nigeria, in consenting eligible hypertensive patients ≥18 years...
July 2017: Annals of African Medicine
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