keyword
MENU ▼
Read by QxMD icon Read
search

CCB

keyword
https://www.readbyqxmd.com/read/29782269/-assessment-of-efficacy-of-combined-pharmacotherapy-with-fixed-perindopril-amlodipine-combination-in-patients-with-combined-cardiovascular-pathology-in-outpatient-practice
#1
E I Bezuglova, Y V Luneva, A A Kornilov, S V Povetkin
AIM: to study effects of using fixed perindopril/amlodipine combination in complex treatment of patients with combined cardiac pathology in active observation mode, in comparison with other angiotensin converting enzyme (ACE inhibitors) or angiotensin II receptor antagonists (ARA), including free combination with calcium channel blockers (CCB) in conditions of routine outpatient practice. MATERIALS AND METHODS: The design of the study included two stages: I - monitoring effectiveness of pharmacotherapy performed in routine outpatient practice (duration of 2 months), II - "active treatment (management)" - changing the pharmacotherapy scheme in patients who did not reach the target level of "office" blood pressure (BP), monitoring patients for 6 months and carrying out, if necessary, dose correction of the newly appointed treatment regimen...
March 2018: Kardiologiia
https://www.readbyqxmd.com/read/29781736/comparison-of-real-world-effectiveness-between-valsartan-and-non-ras-inhibitor-monotherapy-on-the-incidence-of-new-diabetes-in-chinese-hypertensive-patients-an-electronic-health-recording-system-based-study
#2
Tian Shen, Jiwei Wang, Yingjun Yu, Jinming Yu
This study aimed to compare the real-world effectiveness of valsartan and non renin-angiotensin system (non-RAS) agent monotherapy on the incidence of new on-set diabetes (NOD) in Chinese hypertensive patients. It was based on an electronic Health Recording System database from Minhang District of Shanghai. Hypertensive patients aged ≥18 years continuously taking either valsartan or non-RAS agent monotherapy for >12 months were included. Hazard ratios (HR) of NOD events were estimated using propensity score matching method and multivariate regression...
May 21, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29781586/treatment-algorithms-for-systemic-sclerosis-according-to-experts
#3
Andreu Fernández-Codina, Kyle M Walker, Janet E Pope
INTRODUCTION: Treatment for many aspects of systemic sclerosis (SSc) lacks agreement. OBJECTIVES: To generate SSc treatment algorithms endorsed by high percentage of SSc experts. METHODS: Experts from the Scleroderma Clinical Trials Consortium and the Canadian Scleroderma Research group (N=170) were asked whether they agreed with SSc algorithms (from 2012). Two consensus rounds refined agreement; 62 (36%), 54 (32%) and 48 (28%) experts completed surveys...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29779930/a-sialylated-voltage-dependent-ca-2-channel-binds-hemagglutinin-and-mediates-influenza-a-virus-entry-into-mammalian-cells
#4
Yoichiro Fujioka, Shinya Nishide, Toyoyuki Ose, Tadaki Suzuki, Izumi Kato, Hideo Fukuhara, Mari Fujioka, Kosui Horiuchi, Aya O Satoh, Prabha Nepal, Sayaka Kashiwagi, Jing Wang, Mika Horiguchi, Yuko Sato, Sarad Paudel, Asuka Nanbo, Tadaaki Miyazaki, Hideki Hasegawa, Katsumi Maenaka, Yusuke Ohba
Influenza A virus (IAV) infection is initiated by the attachment of the viral glycoprotein hemagglutinin (HA) to sialic acid on the host cell surface. However, the sialic acid-containing receptor crucial for IAV infection has remained unidentified. Here, we show that HA binds to the voltage-dependent Ca2+ channel Cav 1.2 to trigger intracellular Ca2+ oscillations and subsequent IAV entry and replication. IAV entry was inhibited by Ca2+ channel blockers (CCBs) or by knockdown of Cav 1.2. The CCB diltiazem also inhibited virus replication in vivo...
May 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29760223/genomic-heterogeneity-and-the-small-renal-mass
#5
Daiki Ueno, Zuoquan Xie, Marta Boeke, Jamil Syed, Kevin A Nguyen, Patrick McGillivray, Adebowale Adeniran, Peter A Humphrey, Garrett M Dancik, Yuval Kluger, Zongzhi Liu, Harriet M Kluger, Brian Shuch
PURPOSE: Tumor heterogeneity may represent a barrier to pre-operative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors. EXPERIMENTAL DESIGN: We conducted a study from 2013 through 2016, that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy...
May 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29687449/influence-of-3-calcium-channel-blockers-on-gingival-overgrowth-in-a-population-of-severe-refractory-hypertensive-patients
#6
F Vidal, R C de Souza, D C Ferreira, R G Fischer, L S Gonçalves
OBJECTIVE: The aim of the current study was to assess the association between 3 different calcium channel blockers (CCBs) (nifedipine, amlodipine and felodipine) and gingival overgrowth in patients with a diagnosis of severe refractory hypertension. METHODS: One hundred and sixty-two patients with severe refractory hypertension, taking CCBs, were selected. Gingival overgrowth was graded and periodontal measurements were recorded (probing pocket depth, clinical attachment level, plaque index and bleeding on probing)...
April 23, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29656432/calcium-channel-blockers-and-the-incidence-of-breast-and-prostate-cancer-a-meta-analysis
#7
A A Thakur, X Wang, M M Garcia-Betancourt, R A Forse
WHAT IS KNOWN AND OBJECTIVE: Breast cancer (BCa) and prostate cancer (PCa), both hormone-dependent cancers, are the second leading cause of death in both women and men, respectively. Calcium channel blockers (CCBs) have been thought to increase the risk of cancer by inhibiting calcium signal-mediated apoptosis, but the evidence for this association remains inconclusive. We have reviewed pertinent literature and pooled data to establish a consensus on the relationship of CCB use and the incidence of these two cancers...
April 15, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29625974/the-viral-structure-of-the-cuatro-ci%C3%A3-negas-basin-a-unique-oasis-in-northern-mexico-reveals-a-highly-diverse-population-at-a-small-geographic-scale
#8
B Taboada, P Isa, A L Gutiérrez-Escolano, R M Del Ángel, J E Ludert, N Vázquez, M A Tapia-Palacios, P Chávez, E Garrido, A C Espinosa, L E Eguiarte, S López, V Souza, C F Arias
The Cuatro Ciénegas Basin (CCB) is located in the Chihuahuan desert, in the Mexican state of Coahuila; it has been characterized as a site with a biological high diversity despite its extreme oligotrophic conditions. It has the greatest number of endemic species in North America, containing abundant living microbialites (including stromatolites and microbial mats), and diverse microbial communities. With the hypothesis that this large biodiversity and the geographic structure should be reflected in the virome, the viral communities in 11 different locations of three drainage systems: Churince, La Becerra, and Pozas Rojas and in the intestinal content of 3 different fish species were analyzed, looking for both eukaryotic and prokaryotic RNA and DNA viruses, using NGS methods...
April 6, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29615122/effect-of-cyp3-a4-cyp3-a5-and-abcb1-gene-polymorphisms-on-the-clinical-efficacy-of-tacrolimus-in-the-treatment-of-nephrotic-syndrome
#9
Min Li, Min Xu, Wei Liu, Xin Gao
BACKGROUND: The efficacy of tacrolimus (TAC) is variable in the treatment of nephrotic syndrome (NS), which might be related to genetic variation among patients. Therefore, we aim to investigate the effects of CYP3 A4, CYP3 A5 and ABCB1 gene polymorphisms on the clinical efficacy of TAC in the treatment of NS patients. Methods 100 NS patients were treated with TAC and prednisone and followed up for 3 months. Genotype differences (CYP3 A4*1G, CYP3 A5*3, ABCB1 1236C > T and ABCB1 2677G > T/A) were detected by Sanger sequencing...
April 3, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29610630/feasibility-and-safety-of-pleuroscopic-cryobiopsy-of-the-pleura-a-prospective-study
#10
Chia-Hung Chen, Wen-Chien Cheng, Biing-Ru Wu, Chih-Yu Chen, Wei-Chun Chen, Wei-Chih Liao, Chih-Yen Tu
Background: The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods: In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluated with a semirigid pleuroscope between January 2015 and July 2017. Each patient underwent pleural biopsy using flexible forceps and flexible cryoprobe through pleuroscope following diagnostic thoracentesis and closed pleural biopsy (CPB)...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29608546/postdiagnostic-calcium-channel-blocker-use-and-breast-cancer-mortality-a-population-based-cohort-study
#11
John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante, Chris R Cardwell
BACKGROUND: There have long been concerns that calcium channel blockers (CCBs), widely used to treat hypertension, may contribute to malignant growth through the evasion of apoptosis and proliferation of cancer cells. Worryingly, a recent cohort study found breast cancer patients who used CCBs had higher death rates, but interpreting these results was difficult as they were based on all-cause mortality and medication use before cancer diagnosis. We used UK population-based data to more robustly investigate the association between CCB use and cancer-specific mortality...
May 2018: Epidemiology
https://www.readbyqxmd.com/read/29606956/cognitive-blackouts-in-mild-cognitive-impairment-and-alzheimer-s-dementia
#12
Georg Adler, Agnies Marczak, Jana Binder
Background: Cognitive blackouts, e.g. moments of amnesia, disorientation, or perplexity may be an early sign of incipient Alzheimer's dementia (AD). A short questionnaire, the checklist for cognitive blackouts (CCB), was evaluated cross-sectionally in users of a memory clinic. Methods: The CCB was performed in 130 subjects, who further underwent a neuropsychological and clinical examination. Subjective memory impairment and depressive symptoms were assessed. Differences in the CCB score between diagnostic groups and relationships with cognitive performance, depression, and subjective memory impairment were analyzed...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29589516/upgrading-pyrolytic-residue-from-waste-tires-to-commercial-carbon-black
#13
Xue Zhang, Hengxiang Li, Qing Cao, Li'e Jin, Fumeng Wang
The managing and recycling of waste tires has become a worldwide environmental challenge. Among the different disposal methods for waste tires, pyrolysis is regarded as a promising route. How to effectively enhance the added value of pyrolytic residue (PR) from waste tires is a matter of great concern. In this study, the PRs were treated with hydrochloric and hydrofluoric acids in turn under ultrasonic waves. The removal efficiency for the ash and sulfur was investigated. The pyrolytic carbon black (PCB) obtained after treating PR with acids was analyzed by X-ray fluorescence spectrophotometry, Fourier transform infrared spectrometry, X-ray diffractometry, laser Raman spectrometry, scanning electron microscopy, thermogravimetric (TG) analysis, and physisorption apparatus...
March 1, 2018: Waste Management & Research
https://www.readbyqxmd.com/read/29588810/increased-frequency-of-angina-attacks-caused-by-switching-a-brand-name-vasodilator-to-a-generic-vasodilator-in-patients-with-vasospastic-angina-two-case-reports
#14
Remi Goto-Semba, Yuichi Fujii, Tomohiro Ueda, Chikage Oshita, Hiroki Teragawa
It is well known that calcium channel blockers (CCBs) are the first line of therapy for vasospastic angina (VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing...
March 26, 2018: World Journal of Cardiology
https://www.readbyqxmd.com/read/29581605/antihypertensive-prescription-pattern-and-compliance-to-jnc-7-and-jnc-8-at-tertiary-care-government-hospital-hyderabad-india-a-cross-sectional-retrospective-study
#15
Varsha Varakantham, Ashok Kumar Kurakula Sailoo, Dinesh Kumar Bharatraj
Background: The monitoring of hypertension treatment can provide insight into the rational drug use pattern. The objective of this study was to examine the antihypertensive medication use among South Indian adults with hypertension in compliance with the hypertension treatment guidelines (Seventh Joint National Committee [JNC 7] and JNC 8). Methods and Results: A total of 550 hypertensive people aged >25 years were included in this retrospective cross-sectional study. The order of drugs prescribed in the year 2012 was beta blockers (BB) > calcium channel blockers (CCB) > CCB + BB > angiotensin receptor blockers (ARB) > angiotensin-converting enzyme inhibitors (ACEI) > thiazide diuretics, whereas in the year 2014, the order has changed drastically, namely, ACEI > CCB > ARB > BB > thiazide diuretics ( P < ...
April 2018: Hospital Pharmacy
https://www.readbyqxmd.com/read/29559030/effect-of-ssri-and-calcium-channel-blockers-on-depression-symptoms-and-cognitive-function-in-elderly-persons-treated-for-hypertension-three-city-cohort-study
#16
Phillip J Tully, Ruth Peters, Karine Pérès, Kaarin J Anstey, Christophe Tzourio
BACKGROUND: Emerging genetic, ex-vivo, and clinical trial evidence indicates that calcium channel blockers (CCB) can improve mood and cognitive function. The objective of this study was to examine the effect of selective serotonin reuptake inhibitor (SSRI) therapy augmented with CCB on depression and cognitive decline in an elderly population with hypertension. METHODS: Prospective study of 296 persons treated with SSRI and antihypertensive drugs. Baseline and two year clinic assessments were used to categorize participants as users of SSRI + CCB (n = 53) or users of SSRI + other antihypertensives (n = 243)...
March 21, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29541415/sensitization-of-multidrug-resistant-cancer-cells-to-hsp90-inhibitors-by-nsaids-induced-apoptotic-and-autophagic-cell-death
#17
Hyun-Jung Moon, Hak-Bong Kim, Su-Hoon Lee, So-Eun Jeun, Chi-Dug Kang, Sun-Hee Kim
NSAIDs (non-steroidal anti-inflammatory drugs) have potential use as anticancer agents, either alone or in combination with other cancer therapies. We found that NSAIDs including celecoxib (CCB) and ibuprofen (IBU) significantly potentiated the cytotoxicity of Hsp90 inhibitors in human multidrug-resistant (MDR) cells expressing high levels of mutant p53 (mutp53) protein and P-glycoprotein (P-gp), and reversed Hsp90 inhibitor resistance caused by activation of heat shock factor 1 (HSF1) and by up-regulation of heat shock proteins (Hsps) and P-gp...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29534911/incidence-and-morphometry-of-sellar-bridges-and-related-foramina-in-dry-skulls-their-significance-in-middle-cranial-fossa-surgery
#18
Konstantinos Natsis, Maria Piagkou, Nikolaos Lazaridis, Trifon Totlis, Nikolaos Anastasopoulos, Jannis Constantinidis
PURPOSE: The current study investigated the incidence, morphology and morphometry of the ossified ligaments expanding between petrous bone and posterior clinoid processes and in between the anterior, middle and posterior clinoid processes. Side symmetry, gender dimorphism and age influence were also studied. MATERIALS AND METHODS: A total of 123 adult Greek dry skulls were observed. RESULTS: A caroticoclinoid bar (CCB) was found in 60.2%. Partial CCBs appeared more commonly (36...
April 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29532759/amlodipine-150-mg-poisoning-a-case-study
#19
Prasan Kumar Panda, Annu Raj, Shiv Shankar Singh
Treatments of patient with amlodipine (a calcium channel blocker, CCB) overdose/poisoning remain challenging and death is certain if not intervened timely. Furthermore, for a society, the availability and common use of this drug make more vulnerable, especially by children, towards an accidental/suicidal poisoning. Here we describe an adolescent school girl who took 150 mg of amlodipine and was admitted in our hospital approximately 4 hours after ingestion with suicidal intention. She developed circulatory failure and tachypnea...
March 13, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29528482/cryoballoon-ablation-of-atrial-fibrillation-in-patients-with-advanced-systolic-heart-failure-and-cardiac-implantable-electronic-devices
#20
Patrycja Pruszkowska, Radosław Lenarczyk, Jakub Gumprecht, Ewa Jedrzejczyk-Patej, Michał Mazurek, Oskar Kowalski, Adam Sokal, Tomasz Podolecki, Stanisław Morawski, Witold Streb, Katarzyna Mitręga, Zbigniew Kalarus
BACKGROUND: Pulmonary vein isolation with cryobaloon catheter ablation (CCB) is an effective method oftreatment in patients with atrial fibrillation (AF) but in patients with heart failure (HF) therole of CCB remains unknown. AIMS: To assess feasibility, effectiveness and safety of CCB in patients with HF and cardiac electronic devices (CIED), the impact of the procedure on symptoms and echocardiographic parameters. METHODS: Thirty consecutive HF patients with left ventricular ejection fraction (EF)≤40% and CIED, referred for CCB of AF were included...
March 12, 2018: Kardiologia Polska
keyword
keyword
31697
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"