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https://www.readbyqxmd.com/read/28346853/high-prevalence-of-vitamin-d-deficiency-and-correlation-of-serum-vitamin-d-with-cardiovascular-risk-in-patients-with-metabolic-syndrome
#1
Mohammad J Alkhatatbeh, Khalid K Abdul-Razzak, Lubna Q Khasawneh, Nesreen A Saadeh
BACKGROUND: Metabolic syndrome (MetS) identifies subjects with increased risk of cardiovascular disease when they have a combination of insulin resistance, obesity, hypertension, hyperglycemia, low high-density lipoprotein cholesterol (HDL-C), and elevated triglycerides (TGs). Increasing evidence suggests that vitamin D deficiency could be associated with diabetes and MetS. The aim is to assess if 25-hydroxyvitamin D (25-OHD) is correlated with cardiovascular risk components of MetS. METHODS: A cross-sectional study involved 124 diabetic patients with MetS according to International Diabetes Federation definition...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28345768/mycophenolate-mofetil-and-rapamycin-induce-apoptosis-in-the-human-monocytic-u937-cell-line-through-two-different-pathways
#2
Maxime Nowak, Sylviane Tardivel, Thao Nguyen-Khoa, Sonia Abreu, Fatima Allaoui, Natalie Fournier, Pierre Chaminade, Jean-Louis Paul, Bernard Lacour
Transplant vasculopathy may be considered as an accelerated form of atherosclerosis resulting in chronic rejection of vascularized allografts. After organ transplantation, a diffuse intimal thickening is observed, leading to the development of an atherosclerosis plaque due to a significant monocyte infiltration. This results from a chronic inflammatory process induced by the immune response. In this study, we investigated the impact of two immunosuppressive drugs used in therapy initiated after organ transplantation, mycophenolate mofetil and rapamycin, on the apoptotic response of monocytes induced or not by oxidized LDL...
March 27, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28345013/a-pilot-randomized-controlled-clinical-trial-to-assess-tolerance-and-efficacy-of-navy-bean-and-rice-bran-supplementation-for-lowering-cholesterol-in-children
#3
Erica C Borresen, NaNet Jenkins-Puccetti, Katie Schmitz, Dustin G Brown, Austin Pollack, Amanda Fairbanks, Melissa Wdowik, Sangeeta Rao, Tracy L Nelson, Gary Luckasen, Elizabeth P Ryan
Background: Navy beans and rice bran demonstrate efficacy to regulate serum cholesterol in hypercholesterolemic adults; however, the cardiovascular disease (CVD) protective properties of these foods in children are unknown and merit investigation. Objective: The objectives were to determine whether cooked navy bean powder (NBP) and/or heat-stabilized rice bran (RB) supplementation is tolerable, improves dietary fiber intake in children, and modulates lipid profiles. Methods: Children aged 8 to 13 years at risk for CVD due to abnormal lipids were recruited...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28344553/youthful-processing-speed-in-older-adults-genetic-biological-and-behavioral-predictors-of-cognitive-processing-speed-trajectories-in-aging
#4
Nicholas T Bott, Brianne M Bettcher, Jennifer S Yokoyama, Darvis T Frazier, Matthew Wynn, Anna Karydas, Kristine Yaffe, Joel H Kramer
Objective: To examine the impact of genetic, inflammatory, cardiovascular, lifestyle, and neuroanatomical factors on cognitive processing speed (CPS) change over time in functionally intact older adults. Methods: This observational study conducted over two time points, included 120 community dwelling cognitively normal older adults between the ages of 60 and 80 from the University of California San Francisco Memory and Aging Center. Participants were followed with composite measures of CPS, calculated based on norms for 20-30 year-olds...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28344415/percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-in-patients-with-diabetic-nephropathy-and-left-main-coronary-artery-disease
#5
Hsin-Ru Li, Chiao-Po Hsu, Shih-Hsien Sung, Chun-Che Shih, Shing-Jong Lin, Wan-Leong Chan, Cheng-Hsueh Wu, Tse-Min Lu
BACKGROUND: Patients with diabetic nephropathy and unprotected left main (LM) coronary artery disease suffer from high cardiovascular morbidity and mortality. Although surgical revascularization is currently recommended in this special patient population, the optimal revascularization method for this distinct patient group has remained unclear. METHODS: We collected 99 consecutive patients with unprotected LM disease and diabetic nephropathy, including 46 patients who had undergone percutaneous coronary intervention (PCI), and 53 who had coronary artery bypass grafting (CABG), with a mean age of 72 ± 10; with 80...
March 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28344015/transdermal-delivery-of-atorvastatin-calcium-from-novel-nanovesicular-systems-using-polyethylene-glycol-fatty-acid-esters-ameliorated-effect-without-liver-toxicity-in-poloxamer-407-induced-hyperlipidemic-rats
#6
Mohamed O Mahmoud, Heba M Aboud, Amira H Hassan, Adel A Ali, Thomas P Johnston
CONTEXT: Atorvastatin calcium (ATV), a cholesterol-lowering agent, suffers from poor systemic availability (14%) after oral administration in addition to other side effects on the gastrointestinal tract, liver and muscle. OBJECTIVE: The goal of the present investigation was to improve ATV bioavailability and overcome complications attendant with peroral administration by developing a new nanovesicular system encapsulating ATV for its delivery via the transdermal route...
March 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28343601/effects-of-rg7652-a-monoclonal-antibody-against-pcsk9-on-ldl-c-ldl-c-subfractions-and-inflammatory-biomarkers-in-patients-at-high-risk-of-or-with-established-coronary-heart-disease-from-the-phase-2-equator-study
#7
Amos Baruch, Sofia Mosesova, John D Davis, Nageshwar Budha, Alexandr Vilimovskij, Robert Kahn, Kun Peng, Kyra J Cowan, Laura Pascasio Harris, Thomas Gelzleichter, Josh Lehrer, John C Davis, Whittemore G Tingley
RG7652 (MPSK3169A), a fully human immunoglobulin G1 (IgG1) monoclonal antibody directed against proprotein convertase subtilisin/kexin type 9 (PCSK9), blocks the interaction between PCSK9 and low-density lipoprotein (LDL) receptor. EQUATOR (ClinicalTrials.govNCT01609140), a randomized, double-blind, and dose-ranging phase 2 study, evaluated RG7652 in patients (1) at high risk for or (2) with coronary heart disease (CHD). The primary end point was change in LDL cholesterol (LDL-C) from baseline to day 169. Patients (n = 248; median age, 64 years; 57% men; 52% with established CHD; 82% on statins) with baseline LDL-C levels of 90 to 250 mg/dl (mean, 126 mg/dl) continuing on standard-of-care therapy were randomized to receive 1 of 5 RG7652 doses or placebo, subcutaneously every 4, 8, or 12 weeks for 24 weeks...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28343408/safety-of-oral-direct-acting-antiviral-regimens-for-chronic-hepatitis-c-in-real-life-conditions
#8
Regina Juanbeltz, Silvia Goñi Esarte, Juan Isidro Úriz-Otano, Ana Martínez Echeverría, Inmaculada Elizalde, José Manuel Zozaya, Jesús Castilla, Ramón San Miguel
OBJECTIVES: Direct acting antivirals (DAA) are extremely effective to treat chronic hepatitis C. The aim of this study was to evaluate, by using objective variables, the safety of DAA combinations under clinical practice conditions. METHODS: A retrospective study was carried out in mono-infected patients with chronic hepatitis C treated with DAA between January and December 2015 in our centre. Discontinuations, treatment modifications, deaths and laboratory parameters were studied (liver function tests, haemoglobin, creatinine and lipid profile at baseline, weeks 4, 8 and post 12)...
March 27, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28343238/visualization-of-endothelial-barrier-damage-prior-to-formation-of-atherosclerotic-plaques
#9
Heike Bömmel, Florian Kleefeldt, Alma Zernecke, Sharang Ghavampour, Nicole Wagner, Stefanie Kuerten, Süleyman Ergün
En-face fat staining is frequently used to visualize atherosclerotic lesions. This method, however, is not suitable to visualize endothelial barrier damage prior to microscopically detectable morphological alterations of the arterial wall such as sub-endothelial lipid deposition. To enable the investigation of early endothelial barrier damage and in particular the initial steps of atherosclerosis, a new method has to fulfill three requirements: (i) easy and fast to perform, (ii) low cost of applicability without requirement for highly sophisticated technical equipment, and (iii) reliable reproducibility of valid results...
March 25, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28343194/lipid-metabolism-and-feeding-habits-of-indigenous-peoples-of-the-sakha-republic-yakutia-in-today-s-socio-economic-development
#10
Vadim G Krivoshapkin, Anna I Sivtseva, Elena N Sivtseva, Svetlana S Maximova, Leonid F Timofeev, Aytalina S Golderova
INTRODUCTION: By results of a single-step epidemiological research indicators of a lipid range at 355 Evenks of the Olenyoksky District of the Republic of Sakha (Yakutia) are estimated. The aim of this research was assessment of lipid exchange and character of a delivery of Evenks of the item of Zhilinda. MATERIAL AND METHODS: 355 evenks aged over 20 years (170 men, women-185). Total cholesterol (OCHS), cholesterol (low-density lipoproteins (LDL-CHOLESTEROL), highdensity lipoprotein cholesterol ((XC-LVNP), triglycerides (TG), the calculated coefficient of haemoglobin (Ka)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28342772/elucidating-the-structural-organization-of-a-novel-low-density-lipoprotein-nanoparticle-reconstituted-with-docosahexaenoic-acid
#11
Rohit S Mulik, Hui Zheng, Kumar Pichumani, James Ratnakar, Qiu-Xing Jiang, Ian R Corbin
Low-density lipoprotein nanoparticles reconstituted with unesterified docosahexaenoic acid (LDL-DHA) is promising nanomedicine with enhanced physicochemical stability and selective anticancer cytotoxic activity. The unique functionality of LDL-DHA ultimately relates to the structure of this nanoparticle. To date, however, little is known about the structural organization of this nanoparticle. In this study chemical, spectroscopic and electron microscopy analyses were undertaken to elucidate the structural and molecular organization of LDL-DHA nanoparticles...
March 22, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28342665/recombinant-newcastle-disease-virus-expressing-the-infectious-bronchitis-virus-s1-gene-protects-chickens-against-newcastle-disease-virus-and-infectious-bronchitis-virus-challenge
#12
Ran Zhao, Junfeng Sun, Tianming Qi, Wen Zhao, Zongxi Han, Xiaopu Yang, Shengwang Liu
The recombinant LaSota strain expressing a chimeric IBV S1 gene (rLaSota-S1) was constructed with the S1 gene of the LX4 type IBV ck/CH/LDL/091022. The expression of the S1 protein was detected by an indirect immunofluorescence assay and Western blotting. The rLaSota-S1 strain was slightly attenuated, and its growth dynamics were similar to that of the parental LaSota strain. Vaccination of specific pathogen-free chickens with the rLaSota-S1 strain induced NDV hemagglutination inhibition antibodies, and it protected chickens from challenge with virulent NDV...
March 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28342184/the-lipid-lowering-effect-of-levothyroxine-in-patients-with-subclinical-hypothyroidism-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#13
Xiang Li, Yupeng Wang, Qingbo Guan, Jiajun Zhao, Ling Gao
OBJECTIVES: Dyslipidaemia is common in patients with subclinical hypothyroidism (SCH). To date, there is no universal agreement regarding the lipid-lowering effect of substitution treatment with L-T4 in patients with SCH. We aimed to clarify the effect by conducting this systematic review and meta-analysis of randomized controlled trials (RCTs). DESIGN: We systematically searched PubMed, the Cochrane Library, ClinicalTrials. gov and EMBASE for RCTs comparing substitution treatment to placebo treatment or observation...
March 25, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28342064/hdl-cholesterol-reappraisal-of-its-clinical-relevance
#14
REVIEW
Winfried März, Marcus E Kleber, Hubert Scharnagl, Timotheus Speer, Stephen Zewinger, Andreas Ritsch, Klaus G Parhofer, Arnold von Eckardstein, Ulf Landmesser, Ulrich Laufs
BACKGROUND: While several lines of evidence prove that elevated concentrations of low-density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its clinical consequences, high-density lipoproteins are still widely believed to exert atheroprotective effects. Hence, HDL cholesterol (HDL-C) is in general still considered as "good cholesterol". Recent research, however, suggests that this might not always be the case and that a fundamental reassessment of the clinical significance of HDL-C is warranted...
March 24, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28341983/-management-of-different-cardiovascular-risk-factors-with-a%C3%A2-combination-tablet-polypill
#15
REVIEW
P Bramlage, W März, D Westermann, B Weisser, J H Wirtz, U Zeymer, P Baumgart, G van Mark, U Laufs, B K Krämer, T Unger
BACKGROUND: The multifactorial origin of cardiovascular diseases has led to polypharmacy in primary and secondary prophylaxis with evidence-based medications, such as statins, antihypertensive drugs and platelet aggregation inhibitors. The number of prescribed drugs correlates inversely to adherence and can lead to treatment failure. Fixed-dose combination drugs (polypills) could increase the medication adherence of patients, reduce risks and prevent cardiovascular events. METHODS: This review is based on publications that were retrieved from Medline (via PubMed) and The Cochrane Library...
March 24, 2017: Herz
https://www.readbyqxmd.com/read/28341743/adductome-based-identification-of-biomarkers-for-lipid-peroxidation
#16
Takahiro Shibata, Kazuma Shimizu, Keita Hirano, Fumie Nakashima, Ryosuke Kikuchi, Tadashi Matsushita, Koji Uchida
Lipid peroxidation is an endogenous source of aldehydes that give rise to covalent modification of proteins in various pathophysiological states. In the present study, a strategy for the comprehensive detection and comparison of adducts was applied to find a biomarker for lipid peroxidation-modified proteins in vivo. This adductome approach utilized liquid chromatography with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) methods designed to detect the specific product ions from positively ionized adducts in a selected reaction monitoring mode...
March 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28341552/identification-of-a-molecular-signaling-gene-gene-regulatory-network-between-gwas-susceptibility-genes-adtrp-and-mia3-tango1-for-coronary-artery-disease
#17
Chunyan Luo, Fan Wang, Xiang Ren, Tie Ke, Chengqi Xu, Bo Tang, Subo Qin, Yufeng Yao, Qiuyun Chen, Qing Kenneth Wang
Coronary artery disease (CAD) is the leading cause of death worldwide. GWAS have identified >50 genomic loci for CAD, including ADTRP and MIA3/TANGO1. However, it is important to determine whether the GWAS genes form a molecular network. In this study, we have uncovered a novel molecular network between ADTRP and MIA3/TANGO1 for the pathogenesis of CAD. We showed that knockdown of ADTRP expression markedly down-regulated expression of MIA3/TANGO1. Mechanistically, ADTRP positively regulates expression of PIK3R3 encoding the regulatory subunit 3 of PI3K, which leads to activation of AKT, resulting in up-regulation of MIA3/TANGO1...
March 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28341307/the-efficacy-advantage-of-evolocumab-amg-145-dosed-at-140mg-every-2weeks-versus-420mg-every-4weeks-in-patients-with-hypercholesterolemia-evidence-from-a-meta-analysis
#18
Xiao-Xiao He, Rong Zhang, Pei-Yuan Zuo, Yu-Wei Liu, Xiang-Nan Zha, Sheng-Shuai Shan, Cheng-Yun Liu
BACKGROUND: Evolocumab (AMG 145), a PCSK9 inhibitor, has been shown to decrease low-density lipoprotein cholesterol (LDL-C) levels. Doses of 140mg administered every 2weeks (Q2W) and 420mg administered every 4weeks (Q4W) are widely used, and both dosing schedules were effective in clinical trials. However, some researchers have speculated that 140mg Q2W administration has equal or even greater efficacy. This meta-analysis was performed to assess the differences in efficacy and safety between the two doses...
March 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28341248/abnormal-lipid-lipoprotein-metabolism-and-high-plasma-testosterone-levels-in-male-but-not-female-aromatase-knockout-mice
#19
Akiko Amano, Yoshitaka Kondo, Yoshihiro Noda, Mitsuhiro Ohta, Noriaki Kawanishi, Shuichi Machida, Kazuteru Mitsuhashi, Takafumi Senmaru, Michiaki Fukui, Osamu Takaoka, Taisuke Mori, Jo Kitawaki, Masafumi Ono, Toshiji Saibara, Hiroshi Obayashi, Akihito Ishigami
Sex steroid hormones, such as estrogen and testosterone, are believed to play important roles in lipid metabolism. To elucidate the effects of estrogen depletion on lipid metabolism in male and female mice, we used aromatase-knockout (ArKO) mice, in which Cyp19 gene disruption prevented estrogen synthesis in vivo. These mice were divided into the following 4 groups: male and female ArKO mice and male and female wild-type (WT) mice. These mice were fed a normal-fat diet (13.6% fat) ad libitum. At 159 days after birth, the mice were tested for liver and plasma lipid content and hepatic hormone receptor- and lipid/lipoprotein metabolism-related gene expression...
March 21, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28340945/plasma-levels-of-apolipoprotein-e-apoe-genotype-and-risk-of-dementia-and-ischemic-heart-disease-a-review
#20
REVIEW
Katrine Laura Rasmussen
Dementia is one of the major causes of disability in later life, and ischemic heart disease is a leading cause of morbidity and mortality. Apolipoprotein E (apoE) plays a pivotal role in lipoprotein metabolism in the brain and in the periphery, and is implicated in both dementia and ischemic heart disease. Peripherally, liver-derived apoE is the main source of plasma apoE. Approximately half of plasma apoE is associated with triglyceride-rich lipoproteins, where apoE serves as the main ligand for the low density lipoprotein (LDL) receptor and the LDL receptor Related Protein (LRP)...
December 2016: Atherosclerosis
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