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https://www.readbyqxmd.com/read/29029165/depicting-new-pharmacological-strategies-for-familial-hypercholesterolaemia-involving-lipoprotein-a
#1
Alpo Vuorio, Gerald F Watts, Petri T Kovanen
Approximately 35 million people worldwide suffer from heterozygous familial hypercholesterolaemia (HeFH), a condition characterized by genetically determined life-long elevation of plasma low-density lipoprotein cholesterol (LDL-C). One in three of these patients also inherit an elevated plasma concentration of lipoprotein (a) [Lp(a)], a lipoprotein particle with atherogenic, inflammatory and prothrombotic properties. Accordingly, the combination of high plasma LDL-C and Lp(a) can markedly accelerate premature atherosclerotic cardiovascular disease (ASCVD)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29029093/electronegative-low-density-lipoprotein-l5-induces-adipose-tissue-inflammation-associated-with-metabolic-syndrome
#2
Liang-Yin Ke, Hua-Chen Chan, Hsiu-Chuan Chan, Franklin Chikodi Udo Kalu, Hsiang-Chun Lee, I-Ling Lin, Shih-Jie Jhuo, Wen-Ter Lai, Chen-Rong Tsao, Tatsuya Sawamura, Richard A Dixon, Chu-Huang Chen, Chih-Sheng Chu, Shyi-Jang Shin
Context: Electronegative low-density lipoprotein (LDL) L5 is a naturally occurring, atherogenic entity found at elevated levels in the plasma of patients with metabolic syndrome (MetS) in the absence of elevated plasma LDL levels. Objective: To investigate the role of L5 in the mechanism of adipose tissue inflammation associated with MetS. Patients/Setting: Plasma LDL isolated from MetS patients (n=29) and controls (n=29) with similar plasma LDL levels was separated into 5 subfractions, L1-L5, with increasing electronegativity...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29029037/functional-variants-in-the-low-density-lipoprotein-receptor-gene-are-associated-with-clear-cell-renal-cell-carcinoma-susceptibility
#3
Gui-Ming Zhang, Meng-Yun Wang, Ya-Nan Liu, Yao Zhu, Fang-Ning Wan, Qing-Yi Wei, Ding-Wei Ye
Recent studies indicate that abnormal levels of low-density lipoprotein (LDL), which is an important component of dyslipidaemia, are associated with alterations to cancer risk, including that of renal cell carcinoma (RCC). Single nucleotide polymorphisms at microRNA-binding sites contribute to cancer susceptibility and progression by affecting the mRNA function of target genes. In this case-control study, we examined the frequency of six potentially functional single nucleotide polymorphisms in the LDL receptor gene (LDLR) in 1004 clear cell RCC (ccRCC) patients and 1065 cancer-free subjects...
September 22, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29028997/serum-quantitative-proteomic-analysis-reveals-soluble-egfr-to-be-a-marker-of-insulin-resistance-in-male-mice-and-humans
#4
Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Ayuko Kimura, Yu Togashi, Kazuki Tajima, Hisashi Hirano, Yasuo Terauchi
To identify circulating factors as candidates involved in type 2 diabetes (T2DM), we conducted two different quantitative proteomic analyses: 1) db/db mouse sera were compared with db/+ mouse sera obtained at 4, 8, 12, and 24 weeks of age, and 2) db/db mouse sera from animals treated with liraglutide were compared with sera from animals without liraglutide treatment. 20 and eight proteins were differentially expressed in db/db mouse sera in the first experiment and in db/db mouse sera after liraglutide treatment in the second experiment, respectively...
October 5, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028484/cholesterol-target-value-attainment-and-lipid-lowering-therapy-in-patients-with-stable-or-acute-coronary-heart-disease-results-from-the-dyslipidemia-international-study-ii
#5
Anselm K Gitt, Dominik Lautsch, Jean Ferrières, Gaetano M De Ferrari, Ami Vyas, Carl A Baxter, Lori D Bash, Veronica Ashton, Martin Horack, Wael Almahmeed, Fu-Tien Chiang, Kian Keong Poh, Philippe Brudi, Baishali Ambegaonkar
BACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C) is a major contributor to cardiovascular disease. In the Dyslipidemia International Study II (DYSIS II), we determined LDL-C target value attainment, use of lipid-lowering therapy (LLT), and cardiovascular outcomes in patients with stable coronary heart disease (CHD) and those suffering from an acute coronary syndrome (ACS). METHODS: DYSIS II included patients from 18 countries. Patients with either stable CHD or an ACS were enrolled if they were ≥18 years old and had a full lipid profile available...
August 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29028290/plasminogen-activator-inhibitor-1-regulates-the-vascular-expression-of-vitronectin
#6
M Luo, Y Ji, Y Luo, R Li, W P Fay, J Wu
BACKGROUND: Increased expression of vitronectin (VN) by smooth muscle cells (SMCs) promotes neointima formation after vascular injury and may contribute to chronic vascular diseases, such as atherosclerosis. However, the molecular regulation of vascular VN expression is poorly defined. Given the overlapping expression profiles and functions of VN and plasminogen activator inhibitor-1 (PAI-1), we hypothesized that PAI-1 regulates vascular VN expression OBJECTIVES: Determine whether PAI-1 regulates VN expression in SMCs and in vivo...
October 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29028083/association-between-advanced-oxidation-protein-products-aopp-and-vascular-calcification-in-uremic-patients
#7
L Lin, G-J Zhao, L-L Qin
OBJECTIVE: To investigate the correlation between serum advanced oxidation protein products (AOPP) and vascular calcification in uremic patients. PATIENTS AND METHODS: The general data of included subjects were collected, and the serum AOPP, intact parathyroid hormone (iPTH), creatinine (Cre), Urea, calcium (Ca), phosphorus (P), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterin (LDL-C), hemoglobin (Hb) and albumin (ALB) were detected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026969/extended-serum-lipid-profile-predicting-long-term-survival-in-patients-treated-for-abdominal-aortic-aneurysms
#8
Niina Khan, Leo-Pekka Lyytikäinen, Jahangir Khan, Ilkka Seppälä, Antti Lehtomäki, Tommi Kuorilehto, Velipekka Suominen, Terho Lehtimäki, Niku Oksala
BACKGROUND: Individuals treated for abdominal aortic aneurysms (AAAs) are high-risk patients in whom better risk prediction could improve survival. Contemporary serum lipid parameters, such as apolipoproteins and lipoprotein subfractions, may improve or complement the prognostic value of traditional serum lipids. The aim of this study was to ascertain the extended serum lipid profiles, long-term prognosis and their association in AAA patients. METHODS: Altogether 498 patients treated for AAAs and with available serum lipid values were retrospectively analysed...
October 12, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29026804/the-effect-of-cardamom-supplementation-on-serum-lipids-glycemic-indices-and-blood-pressure-in-overweight-and-obese-pre-diabetic-women-a-randomized-controlled-trial
#9
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29026486/martin-s-equation-as-the-most-suitable-method-for-estimation-of-low-density-lipoprotein-cholesterol-levels-in-korean-adults
#10
Mijeong Kang, Jongwoo Kim, Seon Yeong Lee, Kyunam Kim, Junehyung Yoon, Hongseok Ki
BACKGROUND: Friedewald equation is the most widely used method for estimating low-density lipoprotein cholesterol (LDL-C) level. However, due to potential over- or underestimation, many studies have used a modified equation. This study aimed to compare estimates by 4 different equations to directly measured LDL-C concentrations in order to propose the most appropriate method for LDL-C estimation in the Korean population. METHODS: We studied data of 4,350 subjects that included total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and LDL-C concentrations that had been measured at one university hospital in Seoul...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29025430/genetic-architecture-of-lipid-traits-in-the-hispanic-community-health-study-study-of-latinos
#11
Mariaelisa Graff, Leslie S Emery, Anne E Justice, Esteban Parra, Jennifer E Below, Nicholette D Palmer, Chuan Gao, Qing Duan, Adan Valladares-Salgado, Miguel Cruz, Alanna C Morrison, Eric Boerwinkle, Eric A Whitsel, Charles Kooperberg, Alex Reiner, Yun Li, Carlos Jose Rodriguez, Gregory A Talavera, Carl D Langefeld, Lynne E Wagenknecht, Jill M Norris, Kent D Taylor, George Papanicolaou, Eimear Kenny, Ruth J F Loos, Yii-Der Ida Chen, Cathy Laurie, Tamar Sofer, Kari E North
BACKGROUND: Despite ethnic disparities in lipid profiles, there are few genome-wide association studies investigating genetic variation of lipids in non-European ancestry populations. In this study, we present findings from genetic association analyses for total cholesterol, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), and triglycerides in a large Hispanic/Latino cohort in the U.S., the Hispanic Community Health Study / Study of Latinos (HCHS/SOL)...
October 12, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29025201/the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-overweight-korean-children-and-adolescents
#12
Dong-Yoon Yoo, Yu Sun Kang, Eun Byul Kwon, Eun-Gyong Yoo
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025108/hdl-cholesterol-levels-and-risk-of-age-related-macular-degeneration-a-multiethnic-genetic-study-using-mendelian-randomization
#13
Qiao Fan, Joseph C Maranville, Lars Fritsche, Xueling Sim, Chui Ming Gemmy Cheung, Li Jia Chen, Mathias Gorski, Kenji Yamashiro, Jeeyun Ahn, Augustinus Laude, Rajkumar Dorajoo, Tock Han Lim, Yik-Ying Teo, Robert O Blaustein, Nagahisa Yoshimura, Kyu-Hyung Park, Chi Pui Pang, E Shyong Tai, Chiea Chuen Khor, Tien Yin Wong, Heiko Runz, Ching-Yu Cheng
Background: Dyslipidemia, particularly high-density lipoprotein cholesterol (HDL-C), has recently been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of vision loss. However, epidemiological studies have yielded conflicting results. Methods: We investigated the causal role of plasma lipid levels in AMD in multiethnic populations comprising 16 144 advanced AMD cases and 17 832 controls of European descent, together with 2219 cases and 5275 controls of Asian descent, using Mendelian randomization in three models...
September 12, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29024625/effect-of-health-plan-financial-incentive-offering-on-employees-with-prediabetes
#14
Anita D Misra-Hebert, Bo Hu, Phuc H Le, Michael B Rothberg
Background Prediabetes may be improved or reversed with lifestyle interventions. A worksite wellness program offering financial incentives for participation may be effective in improving the health of employees with prediabetes. We studied the effect of employee health plan financial incentives on health outcomes for employees with prediabetes. Methods We conducted a retrospective cohort study using electronic medical record (EMR) data from January 2008- December 2012. Our study participants were employees with prediabetes and propensity-matched non-employees with prediabetes and commercial health insurance, all receiving care within one health system...
October 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29024318/antiphospholipid-antibody-induced-cellular-responses-depend-on-epitope-specificity-implications-for-treatment-of-aps
#15
Nadine Müller-Calleja, Anne Hollerbach, Friederike Häuser, Antje Canisius, Carolin Orning, Karl J Lackner
BACKGROUND: Antiphospholipid antibodies (aPL) contribute to the pathogenesis of the antiphospholipid syndrome (APS) by induction of an inflammatory and procoagulant state in different cell types and several signaling pathways have been described. OBJECTIVES: We hypothesized that signaling depends on epitope specificity of aPL. METHODS: Cellular effects of three human monoclonal aPL with distinctly different epitope specificities were analyzed in vitro...
October 11, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29024030/melatonin-prevents-endothelial-cell-pyroptosis-via-regulation-of-long-noncoding-rna-meg3-mir-223-nlrp3-axis
#16
Yong Zhang, Xin Liu, Xue Bai, Yuan Lin, Zhange Li, Jiangbo Fu, Mingqi Li, Tong Zhao, Huan Yang, Ranchen Xu, Jiamin Li, Jin Ju, Benzhi Cai, Chaoqian Xu, Baofeng Yang
Atherosclerosis (AS) is an inflammatory disease linked to endothelial dysfunction. Melatonin is reported to possess substantial anti-inflammatory properties, which has proven to be effective in AS. Emerging literature suggests that pyroptosis plays a critical role during AS progression. However, whether pyroptosis contributes to endothelial dysfunction and the underlying molecular mechanisms remained unexploited. This study was designed to investigate the anti-pyroptotic effects of melatonin in atherosclerotic endothelium and to elucidate the potential mechanisms...
October 11, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29021813/effect-of-a-short-term-dietary-supplementation-with-phytosterols-red-yeast-rice-or-both-on-lipid-pattern-in-moderately-hypercholesterolemic-subjects-a-three-arm-double-blind-randomized-clinical-trial
#17
Arrigo F G Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D'Addato, Claudio Borghi
BACKGROUND: Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid profile of phytosterols, red yeast rice and their association. METHODS: We performed a three parallel arms, double blind, clinical trial randomizing 90 moderately hypercholesterolemic subjects to treatment with phytosterols 800 mg (group 1), red yeast rice standardized to contain 5 mg monacolins from Monascus purpureus (group 2), or both combined nutraceuticals (group 3)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29021777/circulating-cholesterol-levels-may-link-to-the-factors-influencing-parkinson-s-risk
#18
Lijun Zhang, Xue Wang, Ming Wang, Nick W Sterling, Guangwei Du, Mechelle M Lewis, Tao Yao, Richard B Mailman, Runze Li, Xuemei Huang
OBJECTIVES: A growing literature suggests that circulating cholesterol levels have been associated with Parkinson's disease (PD). In this study, we investigated a possible causal basis for the cholesterol-PD link. METHODS: Fasting plasma cholesterol levels were obtained from 91 PD and 70 age- and gender-matched controls from an NINDS PD Biomarkers Program cohort at the Pennsylvania State University College of Medicine. Based on the literature, genetic polymorphisms in selected cholesterol management genes (APOE, LDLR, LRP1, and LRPAP1) were chosen as confounding variables because they may influence both cholesterol levels and PD risk...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29021285/placental-vitamin-d-metabolism-and-its-associations-with-circulating-vitamin-d-metabolites-in-pregnant-women
#19
Heyjun Park, Madeleine R Wood, Olga V Malysheva, Sara Jones, Saurabh Mehta, Patsy M Brannon, Marie A Caudill
Background: Little is known about placental vitamin D metabolism and its impact on maternal circulating vitamin D concentrations in humans.Objective: This study sought to advance the current understanding of placental vitamin D metabolism and its role in modulating maternal circulating vitamin D metabolites during pregnancy.Design: Nested within a feeding study, 24 healthy pregnant women (26-29 wk of gestation) consumed a single amount of vitamin D (511 IU/d from diet and a cholecalciferol supplement) for 10 wk...
October 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29020971/efficacy-and-safety-of-turmeric-and-curcumin-in-lowering-blood-lipid-levels-in-patients-with-cardiovascular-risk-factors-a-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Si Qin, Lifan Huang, Jiaojiao Gong, Shasha Shen, Juan Huang, Hong Ren, Huaidong Hu
BACKGROUND: Dyslipidemia is an important and common cardiovascular risk factor in the general population. The lipid-lowering effects of turmeric and curcumin are unconfirmed. We performed a meta-analysis to assess the efficacy and safety of turmeric and curcumin in lowering blood lipids in patients at risk of cardiovascular disease (CVD). METHODS: A comprehensive literature search was conducted on PubMed, Embase, Ovid, Medline and Cochrane Library databases to identify randomized controlled trials (published as of November 2016) that assessed the effect of turmeric and curcumin on blood lipid levels including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)...
October 11, 2017: Nutrition Journal
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