keyword
https://read.qxmd.com/read/38520873/increased-extra-neurite-conductivity-of-brain-in-patients-with-alzheimer-s-disease-a-pilot-study
#1
JOURNAL ARTICLE
Seowon Hong, Yunjeong Choi, Mun Bae Lee, Hak Young Rhee, Soonchan Park, Chang-Woo Ryu, Ah Rang Cho, Oh In Kwon, Geon-Ho Jahng
The objectives of this study were to investigate how the extra-neurite conductivity (EC) and intra-neurite conductivity (IC) were reflected in Alzheimer's disease (AD) patients compared with old cognitively normal (CN) people and patients with amnestic mild cognitive impairment (MCI) and to evaluate the association between those conductivity values and cognitive decline. To do this, high-frequency conductivity (HFC) at the Larmor frequency was obtained using MRI-based electrical property tomography (MREPT) and was decomposed into EC and IC using information of multi-shell multi-gradient direction diffusion tensor images...
March 5, 2024: Psychiatry Research. Neuroimaging
https://read.qxmd.com/read/38512090/-features-of-aphasic-disorders-in-patients-with-acute-cerebrovascular-disorder-in-the-posterior-cerebral-artery-basin
#2
JOURNAL ARTICLE
G R Gainetdinova, T V Danilova
Aphasia is a systemic disorder of formed speech that develops as a result of local brain lesions. Most aphasias are characterized by damage to secondary cortical fields, which in turn are responsible for the performance of the functions of gnosis and praxis, which explains the variability in the manifestations of speech disorders in patients with acute cerebrovascular accidents. However, it is necessary in each case to diagnose the central pathological mechanism, which underlies the development of the entire syndrome and determines the entire clinical picture...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38511349/strategic-lacunes-associated-with-mild-cognitive-impairment-in-rural-chinese-older-adults-a-population-based-study
#3
JOURNAL ARTICLE
Jiafeng Wang, Xiaodong Han, Yuanjing Li, Wenxin Fa, Mingqing Zhao, Chunyan Li, Ming Mao, Tingting Hou, Yongxiang Wang, Lin Cong, Lin Song, Yifeng Du, Chengxuan Qiu
BACKGROUND: Lacunes are associated with cognitive impairment. We sought to identify strategic lacune locations associated with mild cognitive impairment (MCI) and subtypes of MCI among older adults, and further to examine the role of white matter hyperintensities and perivascular spaces in the association. METHODS: This population-based cross-sectional study included 1230 dementia-free participants in the brain magnetic resonance imaging substudy (2018-2020) in MIND-China (Multimodal Interventions to Delay Dementia and Disability in Rural China)...
March 21, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38503484/circuit-based-neuromodulation-enhances-delayed-recall-in-amnestic-mild-cognitive-impairment
#4
JOURNAL ARTICLE
Jie Ma, Jia-Jia Wu, Xiang-Xin Xing, Xin Xue, Yun-Ting Xiang, Xiao-Min Zhen, Jian-Hua Li, Juan-Juan Lu, Jun-Peng Zhang, Mou-Xiong Zheng, Xu-Yun Hua, Jian-Guang Xu
BACKGROUND: This study aimed to investigate the efficacy of circuits-based paired associative stimulation (PAS) in adults with amnestic mild cognitive impairment (aMCI). METHODS: We conducted a parallel-group, randomised, controlled clinical trial. Initially, a cohort of healthy subjects was recruited to establish the cortical-hippocampal circuits by tracking white matter fibre connections using diffusion tensor imaging. Subsequently, patients diagnosed with aMCI, matched for age and education, were randomly allocated in a 1:1 ratio to undergo a 2-week intervention, either circuit-based PAS or sham PAS...
March 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/38488454/lost-in-space-s-multimodal-neuroimaging-of-disorientation-along-the-alzheimer-s-disease-continuum
#5
JOURNAL ARTICLE
Gregory Peters-Founshtein, Lidor Gazit, Tahel Naveh, Liran Domachevsky, Amos D Korczyn, Hanna Bernstine, Limor Shaharabani-Gargir, David Groshar, Gad A Marshall, Shahar Arzy
Orientation is a fundamental cognitive faculty and the bedrock of the neurologic examination. Orientation is defined as the alignment between an individual's internal representation and the external world in the spatial, temporal, and social domains. While spatial disorientation is a recognized hallmark of Alzheimer's disease (AD), little is known about disorientation beyond space in AD. This study aimed to explore disorientation in spatial, temporal, and social domains along the AD continuum. Fifty-one participants along the AD continuum performed an ecological orientation task in the spatial, temporal, and social domains while undergoing functional MRI...
March 2024: Human Brain Mapping
https://read.qxmd.com/read/38487076/alzheimer-s-disease-heterogeneity-revealed-by-neuroanatomical-normative-modeling
#6
JOURNAL ARTICLE
Flavia Loreto, Serena Verdi, Seyed Mostafa Kia, Aleksandar Duvnjak, Haneen Hakeem, Anna Fitzgerald, Neva Patel, Johan Lilja, Zarni Win, Richard Perry, Andre F Marquand, James H Cole, Paresh Malhotra
INTRODUCTION: Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding of individual differences in AD-related atrophy. METHODS: We applied neuroanatomical normative modeling to magnetic resonance imaging from a real-world clinical cohort with confirmed AD ( n  = 86). Regional cortical thickness was compared to a healthy reference cohort ( n  = 33,072) and the number of outlying regions was summed (total outlier count) and mapped at individual- and group-levels...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38482142/atypical-clinical-variants-of-alzheimer-s-disease-are-they-really-atypical
#7
JOURNAL ARTICLE
Jennifer L Whitwell
Alzheimer's disease (AD) is a neuropathological disorder defined by the deposition of the proteins, tau and β-amyloid. Alzheimer's disease is commonly thought of as a disease of the elderly that is associated with episodic memory loss. However, the very first patient described with AD was in her 50's with impairments in multiple cognitive domains. It is now clear that AD can present with multiple different non-amnestic clinical variants which have been labeled as atypical variants of AD. Instead of these variants of AD being considered "atypical," I propose that they provide an excellent disease model of AD and reflect the true clinical heterogeneity of AD...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38477907/pure-amnestic-seizure-a-clinico-intracranial-eeg-study
#8
JOURNAL ARTICLE
Norihiko Kawaguchi, Yushi Inoue, Kiyohito Terada, Naotaka Usui
OBJECTIVE: Enduring anterograde amnesia is caused by lesions in bilateral mesial temporal lobes. However, whether transient dysfunction of bilateral mesial temporal regions induces reversible amnesia has not been proven. We investigated this association in patients with epilepsy and analyzed the electroclinical correlation during pure amnestic seizures (PAS). PAS are defined as seizures with anterograde amnesia as the only ictal manifestation, accompanied by preserved responsiveness and other cognitive functions...
March 13, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/38469759/an-atherosclerosis-indicator-hyaluronic-acid-can-plasma-hyaluronic-acid-be-useful-in-diagnosing-alzheimer-s-disease
#9
JOURNAL ARTICLE
Serdar Ceylan, Merve Guner, Arzu Okyar-Bas, Zeynep Kahyaoglu, Neriman S Koc, Gamze N Koksal, Yasin Kiran, Aykut Sagir, Cafer Balci, Meltem G Halil, Mustafa Cankurtaran, Tolga Yildirim, Incilay Lay, Burcu B Dogu
BACKGROUND: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflam-mation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive impairment (aMCI), and normal cognitive functions (NCF). METHODS: Ninety participants were categorized into three groups, patients with AD, MCI, and NCF. Arterial stiffness measurement in the nephrology outpatient clinic, and storage and analysis of plasma samples in the biochemistry laboratory...
March 1, 2024: Clinical Laboratory
https://read.qxmd.com/read/38467658/cognitive-profile-in-cerebral-small-vessel-disease-comparison-between-cerebral-amyloid-angiopathy-and-hypertension-related-microangiopathy
#10
JOURNAL ARTICLE
Eleonora Barucci, Emilia Salvadori, Simona Magi, Martina Squitieri, Giulio Maria Fiore, Lorenzo Ramacciotti, Benedetta Formelli, Francesca Pescini, Anna Poggesi
Cerebral amyloid angiopathy (CAA) is recognized as a cause of cognitive impairment, but its cognitive profile needs to be characterized, also respect to hypertension-related microangiopathy (HA). We aimed at comparing difference or similarity of CAA and HA patients' cognitive profiles, and their associated factors. Participants underwent an extensive clinical, neuropsychological, and neuroimaging protocol. HA patients (n = 39) were more frequently males, with history of vascular risk factors than CAA (n = 32)...
March 11, 2024: Scientific Reports
https://read.qxmd.com/read/38465075/a-rare-case-of-exercise-induced-transient-global-amnesia-as-an-exclusive-presenting-symptom-of-hippocampus-infarct
#11
Roger F Tonna, Azin Azma
Transient global amnesia (TGA) is a rare condition characterized by a temporary loss of the ability to form new memories. Retrograde episodic memory loss may also occur but to a lesser extent. Although TGA is generally benign, its sudden onset and similarity to more dangerous conditions like transient ischemic attack (TIA) or cerebral vascular accident (CVA) can be concerning. We present the case of a 70-year-old female who experienced confusion and general memory loss after a vigorous workout on her stationary exercise bike...
February 2024: Curēus
https://read.qxmd.com/read/38464705/preliminary-experience-with-remimazolam-for-procedural-sedation-and-as-an-adjunct-to-general-anesthesia-during-diagnostic-and-interventional-cardiac-procedures
#12
JOURNAL ARTICLE
Holly Gillis, Christopher McKee, Kristin Chenault, Marco Corridore, Joseph D Tobias
BACKGROUND: Remimazolam is a benzodiazepine which, like midazolam, has sedative, anxiolytic, and amnestic properties. Ester metabolism results in a half-life of 5 - 10 min, a limited context sensitive half-life, and rapid recovery when the infusion is discontinued. METHODS: Following the Institutional Review Board (IRB) approval, we performed a retrospective chart review of patients who received remimazolam in the cardiac catheterization, cardiac magnetic resonance imaging (MRI), and electrophysiology suites...
February 2024: Cardiology Research
https://read.qxmd.com/read/38462045/prevention-of-mk-801-induced-amnestic-effect-with-combined-activation-of-5-ht-1a-and-muscarinic-receptors-in-mice
#13
JOURNAL ARTICLE
Paulina Cieślik, Anna Rafało-Ulińska, Joanna M Wierońska
BACKGROUND: Muscarinic or 5-HT1A receptors are crucial in learning and memory processes, and their expression is evident in the brain areas involved in cognition. The administration of the activators of these receptors prevents the development of cognitive dysfunctions in animal models of schizophrenia induced by MK-801 (N-methyl-d-aspartate receptor antagonist) administration. GABAergic dysfunction is considered as one of the most important causes of MK-801-induced spatial learning deficits...
March 8, 2024: Pharmacology, Biochemistry, and Behavior
https://read.qxmd.com/read/38461504/white-matter-microstructure-analysis-in-subjective-memory-complaints-and-cognitive-impairment-insights-from-diffusion-kurtosis-imaging-and-free-water-dti
#14
JOURNAL ARTICLE
Maurizio Bergamino, Elizabeth Keeling, Molly McElvogue, Sydney Y Schaefer, Anna Burke, George Prigatano, Ashley M Stokes
BACKGROUND: Dementia is characterized by a cognitive decline in memory and other domains that lead to functional impairments. As people age, subjective memory complaints (SMC) become common, where individuals perceive cognitive decline without objective deficits on assessments. SMC can be an early sign and may precede amnestic mild cognitive impairment (MCI), which frequently advances to Alzheimer's disease (AD). OBJECTIVE: This study aims to investigate white matter microstructure in individuals with SMC, in cognitively impaired (CI) cohorts, and in cognitively normal individuals using diffusion kurtosis imaging (DKI) and free water imaging (FWI)...
March 8, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38453029/effective-connectivity-of-the-locus-coeruleus-in-patients-with-late-life-major-depressive-disorder-or-mild-cognitive-impairment
#15
JOURNAL ARTICLE
Pablo Maturana-Quijada, Pamela Chavarría-Elizondo, Inés Del Cerro, Ignacio Martínez-Zalacaín, Asier Juaneda-Seguí, Andrés Guinea-Izquierdo, Jordi Gascón-Bayarri, Ramón Reñé, Mikel Urretavizcaya, José M Menchón, Isidre Ferrer, Virginia Soria, Carles Soriano-Mas
INTRODUCTION: We compared effective connectivity from the locus coeruleus (LC) during the resting-state in patients with late-life Major Depressive Disorder (MDD), individuals with amnestic Mild Cognitive Impairment (aMCI), and Healthy Controls (HCs). PARTICIPANTS: 23 patients with late-life MDD, 22 patients with aMCI, and 28 HCs. MATERIAL AND METHODS: Participants were assessed in two time-points, 2 years apart. They underwent a resting-state functional magnetic resonance imaging and a high-resolution anatomical acquisition, as well as clinical assessments...
March 5, 2024: Span J Psychiatry Ment Health
https://read.qxmd.com/read/38447166/performance-on-the-latin-american-version-of-the-face-name-associative-memory-exam-las-fname-distinguishes-individuals-with-mild-cognitive-impairment-from-age-matched-controls-in-a-sample-from-argentina
#16
JOURNAL ARTICLE
G Keller, N Corvalan, M A Carello, M M Arruabarrena, C Martínez-Canyazo, L De Los Santos, J Spehrs, C Vila-Castelar, R F Allegri, Y T Quiroz, L Crivelli
INTRODUCTION: The Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) has shown promise in identifying cognitive changes in those at risk for Alzheimer's disease (AD). However, its applicability for Mild Cognitive Impairment (MCI) detection in the Latin American population remains unexplored. This study aims to analyze the psychometric properties in terms of validity and reliability and diagnostic performance of the LAS-FNAME for the detection of memory disorders in patients with amnestic MCI (aMCI)...
March 6, 2024: Applied Neuropsychology. Adult
https://read.qxmd.com/read/38444909/longitudinal-default-mode-sub-networks-in-the-language-and-visual-variants-of-alzheimer-s-disease
#17
JOURNAL ARTICLE
Irene Sintini, Nick Corriveau-Lecavalier, David T Jones, Mary M Machulda, Jeffrey L Gunter, Christopher G Schwarz, Hugo Botha, Arenn F Carlos, Michael G Kamykowski, Neha Atulkumar Singh, Ronald C Petersen, Clifford R Jack, Val J Lowe, Jonathan Graff-Radford, Keith A Josephs, Jennifer L Whitwell
Disruption of the default mode network is a hallmark of Alzheimer's disease, which has not been extensively examined in atypical phenotypes. We investigated cross-sectional and 1-year longitudinal changes in default mode network sub-systems in the visual and language variants of Alzheimer's disease, in relation to age and tau. Sixty-one amyloid-positive Alzheimer's disease participants diagnosed with posterior cortical atrophy ( n = 33) or logopenic progressive aphasia ( n = 28) underwent structural MRI, resting-state functional MRI and [18 F]flortaucipir PET...
2024: Brain communications
https://read.qxmd.com/read/38444265/sex-differences-in-functional-connectivity-and-the-predictive-role-of-the-connectome-based-predictive-model-in-alzheimer-s-disease
#18
JOURNAL ARTICLE
Yuqing Li, Wanqiu Zhu, Shanshan Zhou, Hui Li, Ziwen Gao, Ziang Huang, Xiaohu Li, Yongqiang Yu, Xiaoshu Li
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive decline. Sex differences in the progression of AD exist, but the neural mechanisms are not well understood. The purpose of the current study was to explore sex differences in brain functional connectivity (FC) at different stages of AD and their predictive ability on Montreal Cognitive Assessment (MoCA) scores using connectome-based predictive modeling (CPM). Resting-state functional magnetic resonance imaging was collected from 81 AD patients (44 females), 78 amnestic mild cognitive impairment patients (44 females), and 92 healthy controls (50 females)...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38438923/a-proof-of-concept-phase-ii-study-with-the-pde-4-inhibitor-roflumilast-in-patients-with-mild-cognitive-impairment-or-mild-alzheimer-s-disease-dementia-romema-study-protocol-of-a-double-blind-randomized-placebo-controlled-between-subjects-trial
#19
JOURNAL ARTICLE
Nina Possemis, Frans Verhey, Jos Prickaerts, Arjan Blokland, Inez Ramakers
BACKGROUND: Research into the neurobiological underpinnings of learning and memory has demonstrated the cognitive-enhancing effects associated with diverse classes of phosphodiesterase (PDE) inhibitors. Specific PDE inhibitors have been identified to improve neuronal communication through selective inhibition of PDE activity. Roflumilast, a PDE4 inhibitor, has demonstrated efficacy in enhancing episodic memory in healthy adults and elderly participants with pronounced memory impairment, indicative of amnestic mild cognitive impairment (aMCI)...
March 4, 2024: Trials
https://read.qxmd.com/read/38438453/electroencephalography-based-classification-of-alzheimer-s-disease-spectrum-during-computer-based-cognitive-testing
#20
JOURNAL ARTICLE
Seul-Kee Kim, Hayom Kim, Sang Hee Kim, Jung Bin Kim, Laehyun Kim
Alzheimer's disease (AD) is a progressive disease leading to cognitive decline, and to prevent it, researchers seek to diagnose mild cognitive impairment (MCI) early. Particularly, non-amnestic MCI (naMCI) is often mistaken for normal aging as the representative symptom of AD, memory decline, is absent. Subjective cognitive decline (SCD), an intermediate step between normal aging and MCI, is crucial for prediction or early detection of MCI, which determines the presence of AD spectrum pathology. We developed a computer-based cognitive task to classify the presence or absence of AD pathology and stage within the AD spectrum, and attempted to perform multi-stage classification through electroencephalography (EEG) during resting and memory encoding state...
March 4, 2024: Scientific Reports
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