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https://www.readbyqxmd.com/read/29332038/sex-influences-the-accuracy-of-subjective-memory-complaint-reporting-in-older-adults
#1
Erin E Sundermann, Emily C Edmonds, Lisa Delano-Wood, Douglas R Galasko, David P Salmon, Leah H Rubin, Mark W Bondi
Subjective memory complaints (SMC) are required when diagnosing amnestic mild cognitive impairment (aMCI), although their relationship with objective memory performance and Alzheimer's disease (AD) pathology remains unclear. We investigated whether the sex of the patient/participant moderates these associations. Participants were 940 normal control (NC) and aMCI participants from the Alzheimer's Disease Neuroimaging Initiative. SMC were assessed via the memory scale of the Everyday Cognition questionnaire. Discrepancy scores were calculated between self- and informant-reports and categorized into "overestimates," "comparable estimates", and "underestimates" of SMC...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29319601/the-moca-memory-index-score-an-efficient-alternative-to-paragraph-recall-for-the-detection-of-amnestic-mild-cognitive-impairment
#2
Antarpreet Kaur, Steven D Edland, Guerry M Peavy
OBJECTIVE: To compare ability of 2 measures of delayed memory (word list, story paragraph) to discriminate Normal Control (NC) subjects from those with amnestic mild cognitive impairment (aMCI). METHODS: Demographic, neuropsychological, and diagnostic data contributed by 34 Alzheimer's Disease Centers to the National Alzheimer's Coordinating Center characterized 2717 individuals with a diagnosis of either NC (n=2205) or aMCI (n=512). The Montreal Cognitive Assessment-Memory Index Score (MoCA-MIS) assessed delayed word recall, and the Craft Story 21, delayed story recall...
January 9, 2018: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/29315361/networks-of-tau-distribution-in-alzheimer-s-disease
#3
Merle C Hoenig, Gérard N Bischof, Joseph Seemiller, Jochen Hammes, Juraj Kukolja, Özgür A Onur, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Thilo van Eimeren, Alexander Drzezga
A stereotypical anatomical propagation of tau pathology has been described in Alzheimer's disease. According to recent concepts (network degeneration hypothesis), this propagation is thought to be indicative of misfolded tau proteins possibly spreading along functional networks. If true, tau pathology accumulation should correlate in functionally connected brain regions. Therefore, we examined whether independent components could be identified in the distribution pattern of in vivo tau pathology and whether these components correspond with specific functional connectivity networks...
January 5, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29313875/memo-efficacy-durability-and-effect-of-cognitive-training-and-psychosocial-intervention-in-individuals-with-mild-cognitive-impairment
#4
Sylvie Belleville, Carol Hudon, Nathalie Bier, Catherine Brodeur, Brigitte Gilbert, Sébastien Grenier, Marie-Christine Ouellet, Chantal Viscogliosi, Serge Gauthier
BACKGROUND/OBJECTIVES: There is no consensus on the efficacy of cognitive training in persons with mild cognitive impairment (MCI) because of the paucity of well-designed randomized controlled trials. The objective was to assess the effect of memory training on the cognitive functioning of persons with MCI and its durability and to evaluate whether this effect generalizes to daily life and whether positive effects could be obtained from psychosocial intervention. DESIGN: Single-blind randomized controlled trial...
January 4, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29296659/unmasking-the-benefits-of-donepezil-via-psychometrically-precise-identification-of-mild-cognitive-impairment-a-secondary-analysis-of-the-adcs-vitamin-e-and-donepezil-in-mci-study
#5
Emily C Edmonds, M Colin Ard, Steven D Edland, Douglas R Galasko, David P Salmon, Mark W Bondi
Introduction: Criteria for mild cognitive impairment (MCI) used in many clinical trials are susceptible to "false-positive (FP)" errors that can be avoided by an actuarial psychometric approach. Methods: Cluster analysis was applied to baseline neuropsychological test data from 756 MCI participants in the Alzheimer's Disease Cooperative Study donepezil trial. Treatment groups were compared after FP MCI cases were removed. Results: Cluster analyses revealed three groups: "single-domain amnestic MCI" (31%), "multi-domain amnestic MCI" (39%), and "FP MCI" (30%)...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29278893/prediction-model-of-conversion-to-dementia-risk-in-subjects-with-amnestic-mild-cognitive-impairment-a-longitudinal-multi-center-clinic-based-study
#6
Hyemin Jang, Byoung Seok Ye, Sookyoung Woo, Sun Woo Kim, Juhee Chin, Seong Hye Choi, Jee Hyang Jeong, Soo Jin Yoon, Bora Yoon, Kyung Won Park, Yun Jeong Hong, Hee Jin Kim, Samuel N Lockhart, Duk L Na, Sang Won Seo
No abstract text is available yet for this article.
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29261535/limbic-and-basal-ganglia-neuroanatomical-correlates-of-gait-and-executive-function-older-adults-with-mild-cognitive-impairment-and-intact-cognition
#7
Ellen L McGough, Valerie E Kelly, Kurt E Weaver, Rebecca G Logsdon, Susan M McCurry, Kenneth C Pike, Thomas J Grabowski, Linda Teri
OBJECTIVE: This study aimed to examine differences in spatiotemporal gait parameters between older adults with amnestic mild cognitive impairment (aMCI) and normal cognition (NC), and to examine limbic and basal ganglia neural correlates of gait and executive function in older adults without dementia. DESIGN: This was a cross sectional study of 46 community dwelling older adults, ages 70-95 with aMCI (n=23) and NC (n=23). Structural magnetic resonance imaging (MRI) was used to attain volumetric measures of limbic and basal ganglia structures...
December 19, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29242811/patients-with-dementia-are-easily-distracted
#8
R C Hamdy, A Kinser, A Depelteau, T Kendall-Wilson, J V Lewis, K Whalen
Mild cognitive impairment (MCI) is the middle ground between normal, age-appropriate memory impairment, and dementia. Whereas patients with MCI are able to cope with the memory deficit, those with dementia are not: Their memory impairment and other cognitive deficits are of sufficient magnitude to interfere with the patients' ability to cope independently with daily activities. In both MCI and dementia, there is evidence of declining cognitive functions from a previously higher level of functioning. In both the conditions, there is also an evidence of dysfunction in one or more cognitive domains...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29237665/intermittent-catatonia-and-complex-automatisms-caused-by-frontal-lobe-epilepsy-in-dementia
#9
Robynne George, Alex Langford
An 82-year-old man was admitted to the emergency department following bizarre behaviour. Police had noticed him driving erratically through his village. He did not stop when instructed, drove slowly home and appeared 'vacant' on questioning. While in hospital, he had approximately 15 episodes of catatonia, involving rigidity, negativism, mutism except echolalia and perseveration, automatic obedience and utilisation phenomena, lasting 2-20 min each. Between episodes, he was amnestic but otherwise well. Electroencephalography demonstrated bifrontal slowing with left-sided emphasis, and captured two focal onset partial seizures with the clinical correlate of the syndrome described above...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29237555/real-world-navigation-in-amnestic-mild-cognitive-impairment-the-relation-to-visuospatial-memory-and-volume-of-hippocampal-subregions
#10
Jessica Peter, Richard Sandkamp, Lora Minkova, Lena V Schumacher, Christoph P Kaller, Ahmed Abdulkadir, Stefan Klöppel
Spatial disorientation is a frequent symptom in Alzheimer's disease and in mild cognitive impairment (MCI). In the clinical routine, spatial orientation is less often tested with real-world navigation but rather with 2D visuoconstructive tasks. However, reports about the association between the two types of tasks are sparse. Additionally, spatial disorientation has been linked to volume of the right hippocampus but it remains unclear whether right hippocampal subregions have differential involvement in real-world navigation...
December 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29232279/association-of-chronic-obstructive-pulmonary-disease-with-mild-cognitive-impairment-and-dementia
#11
Krishna Kakkera, Kalpana P Padala, Maneetha Kodali, Prasad R Padala
PURPOSE OF REVIEW: As age expectancy increases, both dementia and chronic obstructive pulmonary disease (COPD) have become more prevalent. Dementia and COPD together, however, occur more commonly than would be predicted from the incidence of either alone, suggesting a link between these two common senescent diseases. The purpose of this article is to review the extant literature and report findings in a clinically meaningful manner. We will look at the level of evidence, the risk factors for co-occurrence of the two diseases and the differential effects upon cognitive domains in the population with dementia and COPD...
December 9, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29226864/cardiorespiratory-fitness-and-white-matter-neuronal-fiber-integrity-in-mild-cognitive-impairment
#12
Kan Ding, Takashi Tarumi, David C Zhu, Benjamin Y Tseng, Binu P Thomas, Marcel Turner, Justin Repshas, Diana R Kerwin, Kyle B Womack, Hanzhang Lu, C Munro Cullum, Rong Zhang
BACKGROUND: Mounting evidence showed the self-reported levels of physical activity are positively associated with white matter (WM) integrity and cognitive performance in normal adults and patients with mild cognitive impairment (MCI). However, the objective measure of cardiorespiratory fitness (CRF) was not used in these studies. OBJECTIVE: To determine the associations of CRF measured by maximal oxygen uptake (VO2max) with WM fiber integrity and neurocognitive performance in older adults with MCI...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29223682/neocortical-origin-and-progression-of-gray-matter-atrophy-in-nonamnestic-alzheimer-s-disease
#13
Jeffrey S Phillips, Fulvio Da Re, Laynie Dratch, Sharon X Xie, David J Irwin, Corey T McMillan, Sanjeev N Vaishnavi, Carlo Ferrarese, Edward B Lee, Leslie M Shaw, John Q Trojanowski, David A Wolk, Murray Grossman
Amnestic Alzheimer's disease (AD) is characterized by early atrophy of the hippocampus and medial temporal lobes before spreading to the neocortex. In contrast, nonamnestic Alzheimer's patients have relative sparing of the hippocampus, but the pattern in which the disease spreads is unclear. We examined spreading disease in nonamnestic AD using a novel magnetic resonance imaging-based analysis adapted from pathologic staging studies, applied here to cross-sectional imaging data. We selected 240 T1-weighted scans from 129 patients with pathology confirmed by autopsy or cerebrospinal fluid, and atrophy maps were computed relative to 238 scans from 115 elderly controls...
November 21, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29213523/mild-cognitive-impairment-mci-and-dementia-in-a-sample-of-adults-in-the-city-of-bogot%C3%A3
#14
Olga Lucia Pedraza, Ana Maria Salazar Montes, Fabio Alexander Sierra, Maria Camila Montalvo, Yolanda Muñoz, Jose Miguel Díaz, Angela Lozano, Cesar Piñeros
The low prevalence of dementia described in communities is likely due to the low sensitivity of screening tests and an absence of evaluation by specialists. OBJECTIVE: To estimate the prevalence of mild cognitive impairment (MCI) and dementia in adults older than 50 years. METHODS: A two-phase, cross-sectional study was conducted by specialists to evaluate cognition and associated demographic risk factors in 1,235 independent community-dwelling adults from Bogotá...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213522/memory-specificity-training-can-improve-working-and-prospective-memory-in-amnestic-mild-cognitive-impairment
#15
Golita Emsaki, Hamid Taher NeshatDoost, Mahgol Tavakoli, Majid Barekatain
Amnestic Mild Cognitive Impairment (MCI) is one of the cognitive profiles of aging. OBJECTIVE: In this study, Memory Specificity Training (MEST) was used as cognitive training in patients with amnestic MCI to understand the effectiveness of the intervention on memory dimensions. METHODS: Twenty patients that met the criteria for amnestic MCI were selected and randomly assigned to experimental (n=10) or control (n=10) groups. The experimental group received five sessions of training on memory specificity while the participants in the control group took part in two general placebo sessions...
July 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29211812/a-simulation-study-on-the-impact-of-the-blood-flow-dependent-component-in-18f-av45-suvr-in-alzheimer-s-disease
#16
Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Sebastiaan Engelborghs, Sigrid Stroobants, Steven Staelens
BACKGROUND: Increased brain uptake on [18F]AV45 PET is a biomarker for Alzheimer's disease (AD). The standardised uptake value ratio (SUVR) is widely used for quantification but is subject to variability. Here we evaluate how SUVR of a cortical target region is affected by blood flow changes in the target and two frequently used reference regions. METHODS: Regional baseline time-activity curves (TACs) were simulated based on metabolite-corrected plasma input functions and pharmacokinetic parameters obtained from our previously acquired data in healthy control (HC; n = 10), amnestic mild cognitive impairment (aMCI; n = 15) and AD cohorts (n = 9)...
2017: PloS One
https://www.readbyqxmd.com/read/29210709/alphaxalone-binds-in-inner-transmembrane-%C3%AE-%C3%AE-interfaces-of-%C3%AE-1%C3%AE-3%C3%AE-2-%C3%AE-aminobutyric-acid-type-a-receptors
#17
Alexis M Ziemba, Andrea Szabo, David W Pierce, Marian Haburcak, Alex T Stern, Anahita Nourmahnad, Elizabeth S Halpin, Stuart A Forman
BACKGROUND: Neurosteroids like alphaxalone are potent anxiolytics, anticonvulsants, amnestics, and sedative-hypnotics, with effects linked to enhancement of γ-aminobutyric acid type A (GABAA) receptor gating in the central nervous system. Data locating neurosteroid binding sites on synaptic αβγ GABAA receptors are sparse and inconsistent. Some evidence points to outer transmembrane β-α interfacial pockets, near sites that bind the anesthetics etomidate and propofol. Other evidence suggests that steroids bind more intracellularly in β-α interfaces...
November 28, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29207277/laser-captured-microglia-in-the-alzheimer-s-and-parkinson-s-brain-reveal-unique-regional-expression-profiles-and-suggest-a-potential-role-for-hepatitis-b-in-the-alzheimer-s-brain
#18
Diego Mastroeni, Jennifer Nolz, Shobana Sekar, Elaine Delvaux, Geidy Serrano, Lori Cuyugan, Winnie S Liang, Thomas G Beach, Joseph Rogers, Paul D Coleman
Expression array data from dozens of laboratories, including our own, show significant changes in expression of many genes in Alzheimer's disease (AD) patients compared with normal controls. These data typically rely on brain homogenates, and information about transcripts specific to microglia and other central nervous system (CNS) cell types, which far outnumber microglia-specific transcripts, is lost. We therefore used single-cell laser capture methods to assess the full range of microglia-specific expression changes that occur in different brain regions (substantia nigra and hippocampus CA1) and disease states (AD, Parkinson's disease, and normal controls)...
November 1, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29204119/differential-effects-of-inactivation-of-discrete-regions-of-medial-prefrontal-cortex-on-memory-consolidation-of-moderate-and-intense-inhibitory-avoidance-training
#19
María E Torres-García, Andrea C Medina, Gina L Quirarte, Roberto A Prado-Alcalá
It has been found that the medial prefrontal cortex (mPFC) is involved in memory encoding of aversive events, such as inhibitory avoidance (IA) training. Dissociable roles have been described for different mPFC subregions regarding various memory processes, wherein the anterior cingulate cortex (ACC), prelimbic cortex (PL), and infralimbic cortex (IL) are involved in acquisition, retrieval, and extinction of aversive events, respectively. On the other hand, it has been demonstrated that intense training impedes the effects on memory of treatments that typically interfere with memory consolidation...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29201645/promoter-haplotypes-of-interleukin-10-gene-linked-to-cortex-plasticity-in-subjects-with-risk-of-alzheimer-s-disease
#20
Feng Bai, Chunming Xie, Yonggui Yuan, Yongmei Shi, Zhijun Zhang
The Alzheimer's disease (AD) aetiologic event is associated with brain inflammatory processes. In this study, we consider a haplotype of the IL-10 gene promoter region, - 1082A/- 819 T/- 592A (ATA haplotype), which is an additive and independent genetic risk factor for AD. Episodic memory change is the most striking cognitive alteration in AD. It remains unclear whether episodic memory networks can be affected by the ATA haplotype variant in amnestic mild cognitive impairment (aMCI), and if so, how this occurs...
2018: NeuroImage: Clinical
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