Jie Ma, Jia-Jia Wu, Xiang-Xin Xing, Xin Xue, Yun-Ting Xiang, Xiao-Min Zhen, Jian-Hua Li, Juan-Juan Lu, Jun-Peng Zhang, Mou-Xiong Zheng, Xu-Yun Hua, Jian-Guang Xu
BACKGROUND: This study aimed to investigate the efficacy of circuits-based paired associative stimulation (PAS) in adults with amnestic mild cognitive impairment (aMCI). METHODS: We conducted a parallel-group, randomised, controlled clinical trial. Initially, a cohort of healthy subjects was recruited to establish the cortical-hippocampal circuits by tracking white matter fibre connections using diffusion tensor imaging. Subsequently, patients diagnosed with aMCI, matched for age and education, were randomly allocated in a 1:1 ratio to undergo a 2-week intervention, either circuit-based PAS or sham PAS...
March 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry