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https://www.readbyqxmd.com/read/28070483/increased-hippocampal-activation-in-apoe-4-carriers-and-non-carriers-with-amnestic-mild-cognitive-impairment
#1
Tammy T Tran, Caroline L Speck, Aparna Pisupati, Michela Gallagher, Arnold Bakker
Increased fMRI activation in the hippocampus is recognized as a signature characteristic of the amnestic mild cognitive impairment (aMCI) stage of Alzheimer's disease (AD). Previous work has localized this increased activation to the dentate gyrus/CA3 subregion of the hippocampus and showed a correlation with memory impairments in those patients. Increased hippocampal activation has also been reported in carriers of the ApoE-4 allelic variation independently of mild cognitive impairment although these findings were not localized to a hippocampal subregion...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28068564/distinct-patterns-of-increased-translocator-protein-in-posterior-cortical-atrophy-and-amnestic-alzheimer-s-disease
#2
William C Kreisl, Chul Hyoung Lyoo, Jeih-San Liow, Joseph Snow, Emily Page, Kimberly J Jenko, Cheryl L Morse, Sami S Zoghbi, Victor W Pike, R Scott Turner, Robert B Innis
We sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 11 amnestic AD patients, and 15 age-matched controls underwent positron emission tomography with (11)C-PBR28 to measure translocator protein 18 kDa. PCA patients showed greater (11)C-PBR28 binding than controls in occipital, posterior parietal, and temporal regions...
December 16, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28066141/dehydroevodiamine%C3%A2-hcl-enhances-cognitive-function-in-memory-impaired-rat-models
#3
Ki Young Shin, Ka Young Kim, Yoo-Hun Suh
Progressive memory impairment such as that associated with depression, stroke, and Alzheimer's disease (AD) can interfere with daily life. In particular, AD, which is a progressive neurodegenerative disorder, prominently features a memory and learning impairment that is related to changes in acetylcholine and abnormal β-amyloid (Aβ) deposition in the brain. In the present study, we investigated the effects of dehydroevodiamine·HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a Aβ1-42-infused model...
January 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/28052734/motor-timing-intraindividual-variability-in-amnestic-mild-cognitive-impairment-and-cognitively-intact-elders-at-genetic-risk-for-alzheimer-s-disease
#4
Christina D Kay, Michael Seidenberg, Sally Durgerian, Kristy A Nielson, J Carson Smith, John L Woodard, Stephen M Rao
INTRODUCTION: Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT). METHOD: Two Alzheimer's disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 noncarriers (n = 65) completed the Rey Auditory Verbal Learning Test and the PFTT, which requires index finger tapping in synchrony with a visual stimulus (interstimulus interval = 333 ms)...
January 4, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28039765/exploring-the-contribution-of-spatial-navigation-to-cognitive-functioning-in-older-adults
#5
Jan Laczó, Ross Andel, Zuzana Nedelska, Martin Vyhnalek, Kamil Vlcek, Sebastian Crutch, John Harrison, Jakub Hort
Spatial navigation (SN) impairment is present early in Alzheimer's disease (AD). We tested whether SN performance, self-centered (egocentric) and world-centered (allocentric), was distinguishable from performance on established cognitive functions-verbal and nonverbal memory, executive and visuospatial function, attention/working memory, and language function. 108 older adults (53 cognitively normal [CN] and 55 with amnestic mild cognitive impairment [aMCI]) underwent neuropsychological examination and real-space navigation testing...
December 14, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/28039087/inhibition-of-transcription-and-translation-in-the-striatum-after-memory-reactivation-lack-of-evidence-of-reconsolidation
#6
Roberto A Prado-Alcalá, Andrea Cristina Medina, Paola C Bello-Medina, Gina L Quirarte
It has been found that interference with neural activity after a consolidated memory is retrieved produces an amnestic state; this has been taken has indicative of destabilization of the memory trace that would have been produced by a process of reconsolidation (allowing for maintenance of the original trace). However, a growing body of evidence shows that this is not a reliable effect, and that it is dependent upon some experimental conditions, such as the age of the memory, memory reactivation procedures, the predictability of the reactivation stimulus, and strength of training...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28038387/on-the-nose-olfactory-disturbances-in-patients-with-transient-epileptic-amnesia
#7
Sharon A Savage, Christopher R Butler, Fraser Milton, Yang Han, Adam Z Zeman
OBJECTIVE: While olfactory hallucinations are relatively rare in epilepsy, a high prevalence (up to 42%) has been reported in one form - Transient Epileptic Amnesia (TEA). TEA is characterized by recurring amnestic seizures and is commonly associated with persistent interictal memory deficits. Despite reports of changes in smell, olfactory ability has not been objectively assessed in this group. The aim of this study was to measure olfactory ability in patients with TEA and explore whether olfactory symptoms relate to other clinical variables...
December 27, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28035426/diagnostic-imaging-of-dementia-with-lewy-bodies-by-susceptibility-weighted-imaging-of-nigrosomes-versus-striatal-dopamine-transporter-single-photon-emission-computed-tomography-a-retrospective-observational-study
#8
Koji Kamagata, Tomoya Nakatsuka, Ryuji Sakakibara, Yohei Tsuyusaki, Tomohiro Takamura, Kanako Sato, Michimasa Suzuki, Masaaki Hori, Kanako K Kumamaru, Tsutomu Inaoka, Shigeki Aoki, Hitoshi Terada
INTRODUCTION: The characteristics of dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and amnestic mild cognitive impairment (a-MCI) overlap but require different treatments; therefore, it is important to differentiate these pathologies. Assessment of dopamine uptake in the striatum using dopamine transporter (DaT) single-photon emission computed tomography (SPECT) is the gold standard for diagnosing DLB; however, this modality is expensive, time consuming and involves radiation exposure...
December 29, 2016: Neuroradiology
https://www.readbyqxmd.com/read/28017880/aberrant-spontaneous-low-frequency-brain-activity-in-amnestic-mild-cognitive-impairment-a-meta-analysis-of-resting-state-fmri-studies
#9
REVIEW
PingLei Pan, Lin Zhu, TingTing Yu, HaiCun Shi, Bing Zhang, Ruomeng Qin, Xiaolei Zhu, Lai Qian, Hui Zhao, Hong Zhou, Yun Xu
Recent resting-state functional magnetic resonance imaging (rs-fMRI) studies have provided strong evidence of abnormal spontaneous brain activity in amnestic mild cognitive impairment (aMCI). However, the conclusions have been inconsistent. A meta-analysis of whole-brain rs-fMRI studies that measured differences in the amplitude of low-frequency fluctuations (ALFF) between aMCI patients and healthy controls was conducted using the Seed-based d Mapping software package. Twelve studies reporting 14 datasets were included in the meta-analysis...
December 23, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/28017480/cognitive-reserve-moderates-the-association-between-functional-network-anti-correlations-and-memory-in-mci
#10
Nicolai Franzmeier, Katharina Buerger, Stefan Teipel, Yaakov Stern, Martin Dichgans, Michael Ewers
Cognitive reserve (CR) shows protective effects on cognitive function in older adults. Here, we focused on the effects of CR at the functional network level. We assessed in patients with amnestic mild cognitive impairment (aMCI) whether higher CR moderates the association between low internetwork cross-talk on memory performance. In 2 independent aMCI samples (n = 76 and 93) and healthy controls (HC, n = 36), CR was assessed via years of education and intelligence (IQ). We focused on the anti-correlation between the dorsal attention network (DAN) and an anterior and posterior default mode network (DMN), assessed via sliding time window analysis of resting-state functional magnetic resonance imaging (fMRI)...
February 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28000005/comparison-of-cerebrospinal-fluid-profiles-in-alzheimer-s-disease-with-multiple-cerebral-microbleeds-and-cerebral-amyloid-angiopathy-related-inflammation
#11
Akio Kimura, Masao Takemura, Kuniaki Saito, Nobuaki Yoshikura, Yuichi Hayashi, Naoko Harada, Hiroshi Nishida, Hideto Nakajima, Takashi Inuzuka
Brain magnetic resonance imaging (MRI) of patients with Alzheimer's disease (AD) sometimes reveals multiple cerebral microbleeds (CMBs) and confluent white matter hyperintensities (WMHs) similar to those observed in cerebral amyloid angiopathy-related inflammation (CAA-I). To determine whether there might be common pathophysiological mechanisms underlying the MRI findings of multiple CMBs and confluent WMHs, we investigated the cerebrospinal fluid (CSF) profiles of 38 AD, five amnestic mild cognitive impairment (MCI), and six CAA-I patients...
December 20, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27992572/usefulness-of-dna-methylation-levels-in-coasy-and-spint1-gene-promoter-regions-as-biomarkers-in-diagnosis-of-alzheimer-s-disease-and-amnestic-mild-cognitive-impairment
#12
Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo
In order to conduct early therapeutic interventions for Alzheimer's disease (AD), convenient, early diagnosis markers are required. We previously reported that changes in DNA methylation levels were associated with amnestic mild cognitive impairment (aMCI) and AD. As the results suggested changes in DNA methylation levels in the COASY and SPINT1 gene promoter regions, in the present study we examined DNA methylation in these regions in normal controls (NCs, n = 30), aMCI subjects (n = 28) and AD subjects (n = 30) using methylation-sensitive high resolution melting (MS-HRM) analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27992372/how-does-white-matter-microstructure-differ-between-the-vascular-and-amnestic-mild-cognitive-impairment
#13
Yang Yu, Xinyu Liang, Haikuo Yu, Weina Zhao, Yan Lu, Yue Huang, Changhao Yin, Gaolang Gong, Ying Han
Changes in white matter (WM) microstructure may relate to the pathophysiology of cognitive impairment. Whether WM microstructure differs in two common pre-dementia subtypes, vascular mild cognitive impairment (VaMCI) and amnestic mild cognitive impairment (aMCI), is largely unknown. This study included 28 VaMCI (12 men, age: 46 ~ 77 years) and 34 aMCI patients (14 men, age: 51 ~ 79 years). All patients underwent a battery of neuropsychological tests and structural and diffusion magnetic resonance imaging (MRI) scanning...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27986237/sex-differences-in-the-relationship-between-depressive-symptoms-and-risk-of-amnestic-mild-cognitive-impairment
#14
Erin E Sundermann, Mindy J Katz, Richard B Lipton
OBJECTIVE: The relationship between depressive symptoms and subsequent cognitive impairment in older adults is controversial. Sex differences and the differences in the method of categorizing depressive symptoms may contribute to the inconsistencies. The authors examined the effect of severity of baseline depressive symptoms on risk of incident amnestic mild cognitive impairment (aMCI) separately in men and women. METHODS: Community-dwelling and cognitively healthy older adults (aged ≥ 70 years) from the Einstein Aging Study completed the 15-item Geriatric Depression Scale (GDS-15) at their baseline visit...
January 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27983557/investigating-simulated-driving-errors-in-amnestic-single-and-multiple-domain-mild-cognitive-impairment
#15
Megan A Hird, Kristin A Vesely, Corinne E Fischer, Simon J Graham, Gary Naglie, Tom A Schweizer
The areas of driving impairment characteristic of mild cognitive impairment (MCI) remain unclear. This study compared the simulated driving performance of 24 individuals with MCI, including amnestic single-domain (sd-MCI, n = 11) and amnestic multiple-domain MCI (md-MCI, n = 13), and 20 age-matched controls. Individuals with MCI committed over twice as many driving errors (20.0 versus 9.9), demonstrated difficulty with lane maintenance, and committed more errors during left turns with traffic compared to healthy controls...
December 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27983554/validation-of-the-spanish-version-of-the-lassi-l-for-diagnosing-mild-cognitive-impairment-and-alzheimer-s-disease
#16
Jordi A Matías-Guiu, Rosie E Curiel, Teresa Rognoni, María Valles-Salgado, Marta Fernández-Matarrubia, Roshan Hariramani, Alejandro Fernández-Castro, Teresa Moreno-Ramos, David A Loewenstein, Jorge Matías-Guiu
BACKGROUND: The Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L) is a novel cognitive test that measures recovery from proactive semantic interference, which may be an early cognitive marker of Alzheimer's disease (AD). OBJECTIVE: To generate normative data for a Spaniard population and to validate the LASSI-L for the diagnosis of amnestic mild cognitive impairment (aMCI) and mild AD. METHODS: We performed a cross-sectional study in which 97 healthy participants, 34 with aMCI, and 33 with mild AD were studied with LASSI-L and a comprehensive neuropsychological protocol...
December 9, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27974073/memory-for-emotional-images-differs-according-to-the-presence-of-depressive-symptoms-in-individuals-at-risk-for-dementia
#17
Brandy L Callahan, Robert Laforce, Michel Dugas, Carol Hudon
BACKGROUND: Studies of amnestic mild cognitive impairment (aMCI) and late-life depression (LLD) have examined the similarities and differences between these syndromes, but few have investigated how the cognitive profile of comorbid aMCI and subclinical depressive symptoms (aMCI/D+) may compare to that of aMCI or LLD. Memory biases for certain types of emotional information may distinguish these groups. METHODS: A total of 35 aMCI, 23 aMCI/D+, 13 LLD, and 17 elderly controls (CONT) rated the valence (positive, negative, or neutral) of 30 pictures from the International Affective Picture System...
December 15, 2016: International Psychogeriatrics
https://www.readbyqxmd.com/read/27964994/magnetic-resonance-spectroscopy-and-brain-volumetry-in-mild-cognitive-impairment-a-prospective-study
#18
Nicolás Fayed, Pedro J Modrego, Gracián García-Martí, Roberto Sanz-Requena, Luis Marti-Bonmatí
OBJECTIVE: To assess the accuracy of magnetic resonance spectroscopy (1H-MRS) and brain volumetry in mild cognitive impairment (MCI) to predict conversion to probable Alzheimer's disease (AD). METHODS: Forty-eight patients fulfilling the criteria of amnestic MCI who underwent a conventional magnetic resonance imaging (MRI) followed by MRS, and T1-3D on 1.5 Tesla MR unit. At baseline the patients underwent neuropsychological examination. 1H-MRS of the brain was carried out by exploring the left medial occipital lobe and ventral posterior cingulated cortex (vPCC) using the LCModel software...
December 11, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27960195/propositional-density-in-spoken-and-written-language-of-czech-speaking-patients-with-mild-cognitive-impairment
#19
Filip Smolík, Hana Stepankova, Martin Vyhnálek, Tomáš Nikolai, Karolína Horáková, Štepán Matejka
Purpose: Propositional density (PD) is a measure of content richness in language production that declines in normal aging and more profoundly in dementia. The present study aimed to develop a PD scoring system for Czech and use it to compare PD in language productions of older people with amnestic mild cognitive impairment (aMCI) and control participants matched on age, gender, and education. Method: Groups of patients with aMCI and cognitively healthy control participants (N = 20 each) provided short spoken and written language samples...
December 1, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/27938911/propofol-sedation-in-children-sleep-trumps-amnesia
#20
Robert Veselis, Eric Kelhoffer, Meghana Mehta, James C Root, Fay Robinson, Keira P Mason
OBJECTIVE: Detailed assessments of the effects of propofol on memory in children are lacking. We assessed the feasibility of measuring memory during propofol infusion, as commonly performed in sedation for MRI scanning. In addition, we determined the onset of memory loss in relation to the onset of sedation measured by verbal responsiveness. MATERIALS AND METHODS: Children scheduled for sedation for MRI received a 10-min infusion of propofol (3 mg/kg) as they viewed and named 100 simple line drawings, one shown every five seconds, until they were no longer responsive (encoding)...
November 2016: Sleep Medicine
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