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cleft palate or lip

Laurent A M Thierens, Noëmi M C de Roo, Guy A M de Pauw, Nele Brusselaers
PURPOSE: The use of nonionizing 3-dimensional (3D) imaging in cleft lip and palate (CLP) research is well-established; however, general guidelines concerning the assessment of these images are lacking. The aim of the present study was to review the methods for quantification of soft tissue changes on 3D surface images acquired before and after an orthopedic or surgical intervention in CLP patients. MATERIALS AND METHODS: A systematic literature search was performed using the databases MEDLINE (through PubMed), CENTRAL, Web of Science, and EMBASE...
May 26, 2018: Journal of Oral and Maxillofacial Surgery
Renji Chen, Siyuan Guo, Xin Wang, Yue Mu, Erling Duan, Yi Xu
AIMS: Nonsyndromic cleft lip with or without palate (NSCL/P) represents a complex condition caused by genetic and environmental factors. The aim of this study was to investigate the relationship between the EPHA3 polymorphisms and NSCL/P. MATERIALS AND METHODS: To investigate the relationship between five EPHA3 single nucleotide polymorphisms (SNPs) and NSCL/P, we selected 180 affected patients and 167 normal controls from the Chinese Han Population. EPHA3 SNPs (rs7650466, rs1398197, rs17801309, rs1054750, and rs7632427) were genotyped using the SNaPshot technique and used to perform bioinformatic analyses to determine if any of them were potentially functional SNPs...
June 22, 2018: Genetic Testing and Molecular Biomarkers
Jiewen Dai, Chen Xu, Guomin Wang, Yun Liang, Teng Wan, Yong Zhang, Xiaofeng Xu, Lebin Yu, Zonggang Che, Qiqing Han, Dandan Wu, Yusheng Yang
TBX22 is a gene which contribute to cleft lip/palate, and many mutation sites of TBX22 have been reported. However, the exact role of TBX22 mutation in Chinese nonsyndromic cleft lip/palate (NSCL/P) family was not clearly explored. In this study, we tried to investigate the profiles and effects of TBX22 mutation in Chinese NSCL/P family. Members of two Chinese NSCL/P families and 200 normal controls were enrolled in this study. Further, DNA sequence and bioinformatic analysis for TBX22 were performed. The results showed that a novel and essential splicing site mutation, IVS6-1G>C , was detected in a family with cleft palate...
June 2018: Journal of Genetics
Fernando Almas, Valerie Cote, Elie P Ramly, Rami S Kantar, Usama Hamdan
OBJECTIVE: Evaluating the safety and outcomes of premaxillary setback with posterior vomerine ostectomy in single-stage repair of complete bilateral cleft lip (CBCL) with severe premaxillary protrusion. DESIGN: Retrospective case series. SETTING: Multiple outreach surgical sites. PATIENTS/PARTICIPANTS: From 2012 to 2016, 41 patients with CBCL and severe premaxillary protrusion underwent posterior vomerine premaxillary setback (PVPS) by a single surgeon in Brazil, Ecuador, and Peru...
January 1, 2018: Cleft Palate-craniofacial Journal
Victor Chang, Brendan O'Donnell, William J Bruce, Uma Maduekwe, Max Drescher, Bernandino M Mendez, Anai N Kothari, Parit A Patel
BACKGROUND: The utilization of ambulatory surgical centers (ASCs) for cleft lip repair is increasing to reduce costs. This study better defines the patient population appropriate for ambulatory cleft repair with uplift modeling, a predictive analytics technique. METHODS: Pediatric patients who underwent cleft lip repair were identified in the 2007 to 2011 California Healthcare Cost and Utilization Project State Inpatient Database and State Ambulatory Surgery and Services Database...
January 1, 2018: Cleft Palate-craniofacial Journal
Claudia Resende Leal, Roberta Martinelli de Carvalho, Terumi Okada Ozawa, Araci Malagodi de Almeida, Gisele da Silva Dalben, José Carlos da Cunha Bastos, Daniela Gamba Garib Carreira
OBJECTIVE: To evaluate the influence of cleft type and width, canine eruption stage, and surgeon on the outcomes of alveolar graft with rhBMP-2. DESIGN: Cross-sectional. SETTING: Tertiary craniofacial center. PARTICIPANTS: Ninety individuals submitted to alveolar graft in late mixed or early permanent dentition. INTERVENTIONS: The 90 individuals (mean age: 16.8 years) were submitted to alveolar graft with rhBMP-2...
January 1, 2018: Cleft Palate-craniofacial Journal
Ni Wu, Jun Yan, Tao Han, Jijun Zou, Weimin Shen
BACKGROUND: Orofacial clefts include cleft lip only (CLO), cleft palate only (CPO), and cleft lip with palate (CLP). Previously, we reported the expression profile of plasma microRNAs in CLO, CPO, and CLP, respectively. However, the interaction of each subtype remains poorly investigated. METHODS: In this study, we integrated the expression profiles of plasma miRNAs in these 3 subtypes, and assessed the distinct and overlapping dysregulated miRNAs using Venn diagrams...
June 2018: Medicine (Baltimore)
Lihong Peng, Shijie Tang, Qin Li
OBJECTIVE: To observe the effects of intense pulsed light (IPL) and lattice CO2 laser treatment on scar evolution following cleft lip repair. METHODS: Fifty cleft lip repair patients were enrolled in this study. Twenty-five patients used conventional approach with scar cream massage combined with silica gel products after operation. While other 25 patients which received IPL and lattice CO2 laser treatments. The treatments commenced 1 week after removal of stitches and observation of scar hyperplasia...
June 19, 2018: Journal of Cosmetic Dermatology
Nicholas Rodriguez, Lorena Maili, Brett T Chiquet, Susan H Blanton, Jacqueline T Hecht, Ariadne Letra
BACKGROUND: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a debilitating condition that not only affects the individual, but the entire family. The purpose of this study was to investigate the association of BRCA1 and BRCA2 genes with NSCL/P. METHODS: Twelve polymorphisms in/nearby BRCA1 and BRCA2 were genotyped using Taqman chemistry. Our data set consisted of 3,473 individuals including 2,191 nonHispanic white (NHW) individuals (from 151 multiplex and 348 simplex families) and 1,282 Hispanic individuals (from 92 multiplex and 216 simplex families)...
June 19, 2018: Birth Defects Research
María Del Carmen Pamplona, Pablo Antonio Ysunza
Children with cleft palate frequently show speech and language disorders. In the related scientific literature, several reports have described the use of different strategies for treating speech disorders in children with cleft palate. However, only a few studies have addressed the use of these strategies within a meaningful linguistic context.Deliberate practice is a procedure or strategy, which proposes that the key for achieving high levels of expert performance is dedicating long time for practice. Deliberate practice has been studied mainly in the areas of sports and intellectual games...
June 18, 2018: Journal of Craniofacial Surgery
Ricardo D Bennun, Eduardo Stefano, Luis E Moggi
: Van der Woude syndrome is the most generic form of syndromic orofacial cleft, present in approximately 2% of all cleft patients. The lower lip pits with or without cleft lip and/or palate is typical of this syndrome. Popliteal pterygium syndrome (PPS), also known as popliteal web syndrome or fasciogenito-popliteal syndrome, was first described by Trelat in 1869, the incidence is approximately 1 in 300,000 live births. The term PPS was coined by Gorlin et al in 1968 based on the most unusual anomaly, the popliteal pterygium...
June 18, 2018: Journal of Craniofacial Surgery
Arminder S Kaura, Dhivya R Srinivasa, Steven J Kasten
PURPOSE: Timing of bone grafting for maxillary alveolar clefts is not standardized. Secondary bone grafting is often performed; however, consensus does not exist regarding use of chronologic versus dental age to guide treatment. Several authors suggest an early chronologic age is associated with greater success. Available literature was systematically reviewed for evidence for optimal timing for grafting maxillary alveolar clefts. METHODS: PubMed, MEDLINE, and Cochrane Central Registrar of Controlled Trials databases were queried for manuscripts pertaining to maxillary alveolar cleft bone grafting...
June 18, 2018: Journal of Craniofacial Surgery
Eman Allam, Ahmed Ghoneima, Sunil S Tholpady, Katherine Kula
OBJECTIVE: The aim of this study was to determine whether molar incisor hypomineralization (MIH) is greater in patients with cleft lip and palate (CLP) who underwent primary alveolar grafting (PAG) as compared with CLP waiting for secondary alveolar grafting (SAG) and with controls. DESIGN: A retrospective analysis of intraoral photographs of 13 CLP patients who underwent a PAG, 28 CLP prior to SAG, and 60 controls without CLP was performed. Mantel-Haenszel χ tests were used to compare the 3 groups for differences in MIH scores, and Wilcoxon rank sum tests were used to compare the groups for differences in average MIH scores...
June 19, 2018: Annals of Plastic Surgery
Elisabeth Willadsen, Christina Persson, Duncan Appelbe
Numerous studies have confirmed that prelinguistic utterances are precursors to speech, and there is ample evidence that, for example, frequency of canonical syllables and syllable inventory size correlate with speech and language measures at older ages. Traditionally, prelinguistic utterances have been assessed by phonetic transcription which is difficult and time-consuming in infants. Recently, a more time-efficient methodology to assess prelinguistic utterances in real time, called naturalistic listening, was developed (Ramsdell et al...
June 18, 2018: Clinical Linguistics & Phonetics
Sreevatsan Raghavan, Koshi Philip, Puneet Batra, Agneta Marcusson
Objective: To evaluate the influence of dentofacial attractiveness using the 'Psychosocial Impact of Dental Aesthetics Questionnaire' (PIDAQ), Satisfaction with Life Scale (SWLS) and Aesthetic Component (AC) of the Index of Orthodontic Treatment Need (IOTN) in patients with cleft lip/palate (CLP), and non-cleft orthodontic patients (Non-CLP) and their parents. Materials and methods: Eighty patients (aged 11-19 years) comprising 40 CLP and 40 non-CLP were administered the PIDAQ and SWLS questionnaires to be rated individually by the patients, along with IOTN-AC rated by the patients and their parents, respectively...
April 18, 2018: European Journal of Orthodontics
Patricia L Purcell, Kathleen Cy Sie, Todd C Edwards, Debra Lochner Doyle, Karin Neidt
Objective: This study assessed whether children with oral clefts are appropriately classified as at-risk for hearing loss at the time of newborn hearing screening and describes their screening and diagnostic results. Design: Birth certificates were used to identify children with cleft lip and palate or isolated cleft palate born in Washington State from 2008-2013. These were cross-referenced with the state's Early Hearing Detection, Diagnosis and Intervention (EHDDI) database...
2018: Journal of Early Hearing Detection and Intervention
Moustafa Abdelaziz Moustafa, Alaa Abdelrahman Kandeel, Ahmed M A Habib, Shady A Hassan
Background and Aims: The palatal defect and abnormal dentition in cleft palate make mask ventilation and laryngoscopy difficult. This study aimed to assess the effect of feeding obturator on laryngeal view in unilateral complete cleft palate. Methods: Ninety non-syndromic infants scheduled for the first stage correction of complete unilateral cleft palate were randomised to Group A (no feeding obturator) or Group B (obturator used for induction and intubation). The primary objective was to assess effect of the feeding obturator on the Cormack-Lehane grade on laryngoscopy...
May 2018: Indian Journal of Anaesthesia
Huaxiang Zhao, Wenjie Zhong, Chuntao Leng, Jieni Zhang, Mengqi Zhang, Wenbin Huang, Yunfan Zhang, Weiran Li, Peizeng Jia, Jiuxiang Lin, Gulibaha Maimaitili, Feng Chen
OBJECTIVES: Cleft lip and/or palate (CL/P) is the most common craniofacial congenital disease, and it has a complex aetiology. This study aimed to identify the causative gene mutation of a Han Chinese family with CL/P. SUBJECTS AND METHODS: Whole exome sequencing was conducted on the proband and her mother, who exhibited the same phenotype. A Mendelian dominant inheritance model, allele frequency, mutation regions, functional prediction and literature review were used to screen and filter the variants...
June 16, 2018: Oral Diseases
C M White, M K Hanna
OBJECTIVE: The glans penis may show a deep groove (surgically favorable), or may appear flat with an absent sulcus (unfavorable). Glans dehiscence following hypospadias repair, especially after multiple surgeries, frequently results in a scarred, obliterated, or absent urethral plate. The glans penis appears to be flat and grooveless. This study reported on the outcome of a two-stage salvage repair for glans dehiscence in 49 consecutive patients. MATERIALS AND METHODS: Retrospective chart review was performed for all patients who underwent repair for glans dehiscence following hypospadias repair...
May 30, 2018: Journal of Pediatric Urology
Ricardo Elizondo, Manuel O Lagravère, Esthela Flores, Nora Letechipía
In this article, we demonstrate an effective, cheap, and fast way to shape the nasal alar cartilage in patients with unilateral cleft lip and palate. This technique straightens the vomer and brings the philtrum, columella, premaxilla, and the maxillary frenum to the midsagittal plane, while the alveolar ridges are shaped and positioned. This reduces the lip and palatal cleft to zero even in a 4-week period.
January 1, 2018: Cleft Palate-craniofacial Journal
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