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https://www.readbyqxmd.com/read/29907148/a-case-of-metaplastic-atrophic-gastritis-in-immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-ipex-syndrome
#1
Youyou Luo, Jie Chen, Youhong Fang, Jingan Lou, Jindan Yu
BACKGROUND: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. CASE PRESENTATION: We present the case of a boy with metaplastic atrophic gastritis in whom immune dysregulation, polyendocrinopathy, enteropathy, X-linked(IPEX) syndrome was confirmed by FOXP3 gene mutation...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29906570/randomized-placebo-controlled-phase-iii-trial-of-fosaprepitant-ondansetron-dexamethasone-fond-versus-fond-plus-olanzapine-fond-o-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-patients-with-hematologic-malignancies-receiving-highly-emetogenic
#2
Amber B Clemmons, Julianne Orr, Benjamin Andrick, Arpita Gandhi, Claude Sportes, David DeRemer
Evidence supports olanzapine for prophylaxis of chemotherapy-induced nausea/vomiting (CINV) for highly emetogenic chemotherapy (HEC); however, most studies focus on solid malignancies and single day regimens. A randomized, double-blinded, placebo-controlled trial was conducted to compare addition of olanzapine to triplet therapy (fosaprepitant, ondansetron, dexamethasone; FOND-O) versus triplet therapy alone (FOND) in preventing CINV in hematology patients receiving single and multi-day HEC and hematopoietic cell transplant (HCT) regimens (NCT02635984)...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29904474/posterior-fossa-medulloblastoma-in-an-atypical-extra-axial-location-a-case-report
#3
Elizabeth Presutto, Matthew Chappell, Joseph Fullmer, Sajeev Ezhapilli
Medulloblastoma is the most common posterior fossa tumor of childhood typically within the fourth ventricle. However, extra-axial medulloblastoma in posterior fossa is an uncommon diagnosis. We report a case in a 33-month-old male who presented with repeated complaints of abdominal pain, intermittent emesis, and diarrhea, and diagnosed with right cerebellar extra-axial medulloblastoma, which was surgically resected. Majority of the reported extra-axial medulloblastoma in posterior fossa in the United States are located in the cerebellopontine angle...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29898245/treatment-of-carprofen-overdose-with-therapeutic-plasma-exchange-in-a-dog
#4
Astrid B Kjaergaard, Jennifer L Davis, Mark J Acierno
OBJECTIVE: To report the use of therapeutic plasma exchange (TPE) in a dog with carprofen toxicosis. SUMMARY: A 6-year-old female neutered Bichon Frise weighing 6.9 kg was examined after it had ingested 72 mg/kg carprofen. Mild dehydration without azotemia and with a urine specific gravity of 1.050 was noted at presentation. Treatment consisted of induction of emesis, symptomatic medical therapy, and TPE. The TPE achieved 1.5 plasma volume exchanges over 3 hours...
June 13, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29893452/aprepitant-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-paediatric-subjects-an-analysis-by-age-group
#5
Hyoung Jin Kang, Susan Loftus, Cara DiCristina, Stuart Green, Annpey Pong, Christian Michel Zwaan
BACKGROUND: This was a subgroup analysis of age group, dexamethasone use, and very highly emetogenic chemotherapy (VHEC) use from a randomised, multicentre, double-blind, Phase 3 study of oral aprepitant in paediatric subjects. METHODS: Subjects aged 6 months to 17 years scheduled to receive chemotherapeutic agents associated with at least moderate risk for emesis were randomly assigned to receive either aprepitant plus ondansetron (aprepitant regimen) or placebo plus ondansetron (control regimen); both could be administered with or without dexamethasone...
June 12, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29887332/balloon-dacryoplasty-for-congenital-nasolacrimal-duct-obstruction-a-report-by-the-american-academy-of-ophthalmology
#6
Edward J Wladis, Vinay K Aakalu, Michael T Yen, Jurij R Bilyk, Rachel K Sobel, Louise A Mawn
PURPOSE: To identify the efficacy and adverse event rates of balloon dacryoplasty in cases of congenital nasolacrimal duct obstruction in children who fail to respond to an initial nasolacrimal duct probing. METHODS: A literature search was last performed in September 2017 in the PubMed database to identify all reports of balloon dacryoplasty. All searches up to and including the last search were limited to the English language, and they yielded 104 articles that were assessed for relevancy...
June 7, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29882681/vagal-nerve-stimulation-for-intractable-hiccups-is-not-a-panacea-a-case-report-and-review-of-the-literature
#7
Sanjeet S Grewal, Andrea C Adams, Jamie J Van Gompel
INTRODUCTION: Hiccups are common and typically resolve spontaneously. However, in rare cases, they can continue for days, weeks or even years, causing significant morbidity and discomfort in patients. In the setting of intractable hiccups, vagal nerve stimulation has been reported in two cases. OBJECTIVES: This is a case report and review of the literature regarding the use of vagal nerve stimulators for intractable hiccups. Specifically, this report highlights a case where this therapy was not effective, as two prior case reports have reported positive results...
June 8, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29882488/orbital-and-nasal-meningoencephaloceles-secondary-to-chronic-hydrocephalus-a-rare-cause-of-bilateral-proptosis
#8
Zachary B Jenner, Nuruddin Husein, Roy Riascos, Yoshua Esquenazi
Introduction Orbital meningoencephalocele formation is primarily a result of congenital defects in the pediatric population and trauma of the anterior cranial fossa in adults. We present a unique case of nontraumatic nasal and orbital meningoencephaloceles presenting as bilateral proptosis with exotropia secondary to chronic hydrocephalus. Clinical presentation A 20-year-old male with a history of tuberous sclerosis, X-linked intellectual disability, and epilepsy presented to the emergency department with two days of nausea, emesis, seizures, and two months of progressive proptosis...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29881601/a-retrospective-review-of-treatment-patterns-of-antiemetic-agents-for-chemotherapy-induced-nausea-and-vomiting
#9
Abdulrahman Alamri, Yousef A Alawlah, Yanru Qiao, Junling Wang
Objectives: To evaluate the treatment pattern of antiemetic agents used for chemotherapy-induced nausea and vomiting in a tertiary hospital in Saudi Arabia. Methods: Over a period of 7 weeks, all new chemotherapy order sheets were collected and evaluated for chemotherapy-induced nausea and vomiting management. We compared each antiemetic regimen used for chemotherapy-induced nausea and vomiting prophylaxis with three international antiemetic guidelines by the following organizations: the Multinational Association of Supportive Care in Cancer, the American Society of Clinical Oncology, and the National Comprehensive Cancer Network for the clinician...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29873151/head-trauma-in-the-haemophilic-child-and-management-in-a-paediatric-emergency-department-descriptive-study
#10
P García Sánchez, M Á Molina Gutiérrez, J Martín Sánchez, L Inisterra Viu, S García García, M I Rivas Pollmar, M Martín Salces, M T Álvarez Román, V Jiménez Yuste
INTRODUCTION: Haemophilia is one of the most common inherited bleeding disorders in the Emergency Department (ED). The most dangerous site of bleeding is the central nervous system. AIMS: To describe the characteristics of haemophiliacs arrived to our ED following a head trauma and to analyse the incidence of intracranial haemorrhage (ICH). MATERIALS AND METHODS: Retrospective, analytical, observational study, conducted in a Paediatric ED...
June 6, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29866227/acute-massive-gastrointestinal-bleeding-in-the-elderly
#11
Jian-Yuan Gao, Jin-Feng Chen, Hui Su, Hai-Ying Fang, Li-Ping Wu, Ya-Jun Han, Xiao-Ming Wang
An 82-year patient presented with nausea, coffee-ground emesis, melena and hematochezia on July 10, 2011. The patient received blood transfusion on July 11, and continued to bleed from July 12 to 17. The patient underwent upper gastrointestinal endoscopy on July 16. There were no abnormalities in the esophagus, stomach and duodenum. Then the patient presented with shortness of breath, extreme fear, fatigue, hypotension, sweating, and cold limbs. Dopamine, as well as pressurised infusion of packed red blood cells and fresh frozen plasma were given to the patient to maintain blood pressure...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29850445/effect-of-aromatherapy-with-peppermint-oil-on-the-severity-of-nausea-and-vomiting-in-pregnancy-a-single-blind-randomized-placebo-controlled-trial
#12
Narges Joulaeerad, Giti Ozgoli, Homa Hajimehdipoor, Erfan Ghasemi, Fatemeh Salehimoghaddam
Background: Nausea and vomiting are common complaints in the first half of pregnancy. These symptoms can significantly affect a person's personal and professional life. Aromatherapy is one of the types of complementary medicine that is used in the treatment of nausea and vomiting. The objective of this study was to determine the effect of aromatherapy with peppermint oil on the severity of nausea and vomiting of pregnancy (NVP). Methods: This was a single-blind clinical trial that was conducted on 56 pregnant women with mild to moderate severity of NVP and 6 to 20 weeks of gestational age...
January 2018: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/29850386/acute-esophageal-necrosis-a-case-series
#13
Leon D Averbukh, Marianna G Mavilia, Grigoriy E Gurvits
Acute esophageal necrosis (AEN) is a particularly rare syndrome with an incidence of only 0.1-0.28%, whose appearance is notable for proximal extensions of black, necrotic appearing mucosa extending proximally in the esophagus and abruptly interrupted at the gastroesophageal junction. In this case series, we explore the cases of two males: one middle-aged and one elderly, who after presenting with emesis, were found to have acute esophageal necrosis on esophagogastroduodenoscopy.
March 29, 2018: Curēus
https://www.readbyqxmd.com/read/29846280/brincidofovir-cmx001-toxicity-associated-with-epithelial-apoptosis-and-crypt-drop-out-in-a-hematopoietic-cell-transplant-patient-challenges-in-distinguishing-drug-toxicity-from-gvhd
#14
Claire J Detweiler, Sarah B Mueller, Anthony D Sung, Jennifer L Saullo, Vinod K Prasad, Diana M Cardona
Brincidofovir (CMX001) is an oral agent with activity against double-strand DNA viruses undergoing clinical trials in immunocompromised patients. We report a patient clinically diagnosed with brincidofovir-related gastrointestinal (GI) toxicity and his histologic findings. A 2-year-old boy with medulloblastoma undergoing autologous hematopoietic cell transplantation developed adenovirus viremia 9 days posttransplant. After initial treatment with intravenous cidofovir he was started on oral brincidofovir as part of a clinical trial...
May 25, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29845459/synthesis-characterization-and-biocompatibility-of-n-palmitoyl-l-alanine-based-organogels-as-sustained-implants-of-granisetron-and-evaluation-of-thier-antiemetic-effect
#15
Hala Bakr El-Nassan, Aliaa Nabil ElMeshad, Walaa Wadie, Rabab H Sayed
PURPOSE: To assess the gelation power of N-palmitoyl L-alanine derivatives in injectable oils and to use the best chosen organogel as parenteral implant of granisetron for the treatment of emesis. METHODS: Twelve N-palmitoyl L-alanine derived organogels were developed and evaluated in terms of morphology, thermal properties and in vivo performance. The ability of the selected formula to form in situ gel upon subcutaneous injection in rats and its biocompatibility were monitored over 2 weeks by histopathological examination of the injection site...
May 29, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29808378/impact-of-radiation-induced-nausea-and-vomiting-on-quality-of-life
#16
Caitlin Yee, Leah Drost, Liying Zhang, Bo Angela Wan, Vithusha Ganesh, May Tsao, Elizabeth Barnes, Mark Pasetka, Carlo DeAngelis, Edward Chow
PURPOSE: Radiotherapy-induced nausea and vomiting is a common side effect of radiotherapy. It is well-established that nausea and vomiting have a negative impact on quality of life, but the relative influence of each of symptom is infrequently reported. This study aimed to compare the effects of nausea and vomiting on quality of life in cancer patients receiving palliative radiotherapy. METHODS: The Functional Living Index-Emesis (FLIE) is a quality of life questionnaire developed in the chemotherapy-induced nausea and vomiting setting...
May 28, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29796708/should-palonosetron-be-a-preferred-5-ht-3-receptor-antagonist-for-chemotherapy-induced-nausea-and-vomiting-an-updated-systematic-review-and-meta-analysis
#17
REVIEW
Ronald Chow, David G Warr, Rudolph M Navari, May Tsao, Marko Popovic, Leonard Chiu, Milica Milakovic, Henry Lam, Carlo DeAngelis
PURPOSE: Chemotherapy-induced nausea and vomiting (CINV) continues to be a common side effect of systemic anticancer therapy, decreasing quality of life and increasing resource utilization. The aim of this meta-analysis was to investigate the comparative efficacy and safety of palonosetron relative to other 5-HT3 RAs. METHODS: A literature search was carried out in Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. Full-text references were then screened and included in this meta-analysis if they were an RCT and had adequate data regarding one of the five primary endpoints-complete response (CR), complete control (CC), no emesis, no nausea, or no rescue medications...
May 23, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29796359/acute-appendicitis-in-young-children-a-persistent-diagnostic-challenge-for-clinicians
#18
Kewan A Hamid, Mohamed A Mohamed, Anas Salih
Acute appendicitis is a grave and life-threatening condition in children, accounting for one to two cases per 10,000 in children less than four years' old. Prompt diagnosis and management are imperative to prevent serious complications, such as abscess formation, perforation, bowel obstruction, peritonitis, and sepsis. In young children, however, the diagnosis of this condition is challenging. The delayed utilization of imaging may further delay the diagnosis due to concerns of exposure to ionizing radiation...
March 19, 2018: Curēus
https://www.readbyqxmd.com/read/29794645/evaluation-of-the-use-of-fosaprepitant-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-pediatric-patients
#19
Sarah Timaeus, Joshua Elder, Kyle Franco
A neurokinin-1 (NK1) receptor antagonist is recommended with a 5-HT3 receptor antagonist and dexamethasone for prevention of chemotherapy-induced nausea and vomiting (CINV) in adult patients receiving highly emetogenic chemotherapy. Data for fosaprepitant use in pediatric patients is lacking. A retrospective chart review was conducted using an electronic medical record to characterize the use of fosaprepitant in patients aged 10 months to 18 years at a single institution from August 2015 to January 2017. Thirty-nine patients received fosaprepitant 4 mg/kg (maximum, 150 mg) for prevention of CINV, and 35 were included in the analysis...
May 22, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29794499/efficacy-and-safety-of-oral-nepa-netupitant-palonosetron-the-first-fixed-combination-antiemetic-in-patients-with-gynecological-cancers-receiving-platinum-based-chemotherapy
#20
Snežana M Bošnjak, Ljiljana Stamatovic, Maria Elisa Borroni, Giada Rizzi, Karin Jordan
OBJECTIVE: Patients with gynecological cancers are at high risk for chemotherapy-induced nausea and vomiting (CINV) after platinum-based chemotherapy (CT). NEPA (300-mg netupitant, 0.50-mg palonosetron) is the first oral fixed-combination antiemetic. Pivotal trials demonstrated the superiority of oral NEPA over intravenous palonosetron in preventing CINV after highly emetogenic (anthracycline-cyclophosphamide-based [AC] and cisplatin-based [non-AC]) CT. This post hoc subset analysis considered patients with gynecological cancer receiving cisplatin- or carboplatin-based CT from 1 pivotal trial and from 1 multicycle safety trial to evaluate the efficacy of oral NEPA in preventing CINV...
May 23, 2018: International Journal of Gynecological Cancer
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