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inflammatory bowel diseases

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https://www.readbyqxmd.com/read/28103499/incarcerated-incisional-hernia-of-the-sigmoid-colon-after-appendectomy-a-case-report
#1
Pyong Wha Choi
INTRODUCTION: Incisional hernia after appendectomy is rare, affecting 0.4% to 0.9% of cases. The small bowel and omentum are commonly herniated through the abdominal wall defect, but incisional hernia of the sigmoid colon is extremely rare. CASE PRESENTATION: A 78-year-old man presented with a right lower quadrant abdominal wall mass on the previous McBurney incision site. He had a history of appendectomy for appendicitis 40 years ago. Computed tomography (CT) showed the sigmoid colon herniated thorough the abdominal wall defect...
January 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28103205/is-the-use-of-agile-patency-capsule-prior-to-videocapsule-endoscopy-useful-in-all-patients-with-spondyloarthritis
#2
Andrada Gheorghe, Denise Carmen Mihaela Zahiu, Theodor Alexandru Voiosu, Bogdan Radu Mateescu, Mihail Radu Voiosu, Mihai Rimbaş
BACKGROUND AND AIMS: As already known, spondyloarthritis patients present a striking resemblance in intestinal inflammation with early Crohn's disease. Moreover, the frequent use of nonsteroidal anti-inflammatory drugs is an important part of their treatment. Both conditions could lead to intestinal stenoses. Therefore we proposed to investigate the usefulness of the patency capsule test in patients with spondyloarthritis. MATERIAL AND METHODS: 64 consecutive patients (33 males; mean age 38 ± 11 years) that fulfilled the AMOR criteria for seronegative spondyloarthropathy (59...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28103201/different-effects-of-anti-tnf-alpha-biologic-drugs-on-the-small-bowel-macroscopic-inflammation-in-patients-with-ankylosing-spondylitis
#3
A Chitul, A M Voiosu, Mădălina Marinescu, Simona Caraiola, Adriana Nicolau, Georgeta Camelia Badea, Magda Ileana Pârvu, R A Ionescu, B R Mateescu, M R Voiosu, C R Băicuș, M Rimbaș
: Background&Aims: Considering the ability of anti-TNF alpha drugs to lower the burden intestinal inflammation in patients with inflammatory bowel disease (IBD), and the similarity between IBD and ankylosing spondylitis (AS) regarding inflammatory intestinal involvement, we aimed to investigate the impact of anti-TNF alpha biologic therapy on subclinical intestinal inflammation in AS patients. METHODS: Between January 2008 and December 2013, 38 AS patients and 23 controls were enrolled in the study and investigated with small bowel videocapsule endoscopy examination and ileocolonoscopy...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28103145/can-you-cause-inflammatory-bowel-disease-with-fecal-transplantation-a-31-patient-case-series-of-fecal-transplantation-using-stool-from-a-donor-who-later-developed-crohn-s-disease
#4
Monika Fischer, Mohamad Bittar, Eliseo Papa, Zain Kassam, Mark Smith
No abstract text is available yet for this article.
January 19, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28102860/psychological-interventions-for-irritable-bowel-syndrome-and-inflammatory-bowel-diseases
#5
Sarah Ballou, Laurie Keefer
Psychological interventions have been designed and implemented effectively in a wide range of medical conditions, including Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Diseases (IBD). The psychological treatments for IBS and IBD with the strongest evidence base include: cognitive behavioral therapy, hypnosis, and mindfulness-based therapies. The evidence for each of these therapies is reviewed here for both IBS and IBD. In general, there is a stronger and larger evidence base to support the use of psychological interventions in IBS compared with IBD...
January 19, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28102757/dysbiosis-in-crohn-s-disease-joint-action-of-stochastic-injuries-and-focal-inflammation-in-the-gut
#6
Ludovica F Buttó, Dirk Haller
Gut homeostasis involves interrelated biological networks that include the immune system, specialized cells of the epithelium, such as Paneth and goblet cells, as well as triggers derived from the microbiota. Disruption of these homeostatic interactions may lead to the pathogenesis of inflammatory bowel diseases (IBD). To develop more targeted and individual treatments in Crohn's disease and ulcerative colitis, it becomes more and more important to link key mechanisms of the disease pathogenesis to distinct IBD subsets...
January 19, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28102756/treatment-of-recurrent-clostridium-difficile-infection-using-fecal-microbiota-transplantation-in-patients-with-inflammatory-bowel-disease
#7
Krista M Newman, Kevin M Rank, Byron P Vaughn, Alexander Khoruts
We recently compared results of fecal microbiota transplantation (FMT) in patients with refractory, recurrent Clostridium difficile infection (rCDI), with and without underlying inflammatory bowel disease (IBD). Here we extend this cohort and analyze outcomes in greater detail by subtype of IBD. We find that FMT is generally effective in breaking the cycle of CDI recurrence, but its effects on overall IBD progression are much less predictable. We discuss a number of challenges intrinsic to this complex clinical situation and outline the next steps that can address these challenges going forward...
January 19, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28102669/intervention-of-isomaltodextrin-mitigates-intestinal-inflammation-in-a-dextran-sodium-sulfate-induced-mouse-model-of-colitis-via-inhibition-of-toll-like-receptor-4
#8
Kaustav Majumder, Toshihiko Fukuda, Hua Zhang, Takeo Sakurai, Yoshifumi Taniguchi, Hikaru Watanabe, Hitoshi Mitsuzumi, Toshiro Matsui, Yoshinori Mine
Isomaltodextrin (IMD), a highly branched α-glucan, is a type of resistant starch. Earlier studies have indicated that polysaccharides could prevent inflammation and can be effective in reducing the complications of chronic gastrointestinal diseases such as inflammatory bowel disease (IBD). Therefore, the aim of the present study was to evaluate the anti-inflammatory effect of IMD in dextran sodium sulfate (DSS)-induced colitis in a mouse model. IMD (0.5, 1.0, 2.5, and 5.0% (w/v)) was given orally for 23 days to female Balb/c mice, and then 5% DSS was administered to induce colitis (from day 15 onward to the end of the trial)...
January 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28102560/the-epidemiology-of-inflammatory-bowel-diseases-from-west-to-east
#9
Zsuzsanna Vegh, Zsuzsanna Kurti, Peter Lakatos
The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographic regions. The first studies on the epidemiology of IBD were available mainly from traditionally high-incidence areas, as North America and Northern and Western Europe. In the last two decades, more and more data have been reported from Eastern European and Asian counties with increasing incidence rates from some regions. According to recent studies, the high incidence and prevalence of IBD in some Western countries is plateauing and in some Eastern countries increasing incidence rates have been reported...
January 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28102115/can-probiotics-modulate-human-disease-by-impacting-intestinal-barrier-function
#10
Peter A Bron, Michiel Kleerebezem, Robert-Jan Brummer, Patrice D Cani, Annick Mercenier, Thomas T MacDonald, Clara L Garcia-Ródenas, Jerry M Wells
Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease...
January 19, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28101306/essential-role-of-small-bowel-capsule-endoscopy-in-reclassification-of-colonic-inflammatory-bowel-disease-type-unclassified
#11
Sara Monteiro, Francisca Dias de Castro, Pedro Boal Carvalho, Bruno Rosa, Maria João Moreira, Rolando Pinho, Miguel Mascarenhas Saraiva, José Cotter
AIM: To evaluate the role of small bowel capsule endoscopy (SBCE) on the reclassification of colonic inflammatory bowel disease type unclassified (IBDU). METHODS: We performed a multicenter, retrospective study including patients with IBDU undergoing SBCE, between 2002 and 2014. SBCE studies were reviewed and the inflammatory activity was evaluated by determining the Lewis score (LS). Inflammatory activity was considered significant and consistent with Crohn's disease (CD) when the LS ≥ 135...
January 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28100889/cotransfer-of-regulatory-t-cells-improve-the-therapeutic-effectiveness-of-mesenchymal-stem-cells-in-treating-a-colitis-mouse-model
#12
Yang Yu, Tianyu Zhao, Deqin Yang
Inflammatory bowel disease (IBD) is a severe inflammatory condition in the colon. To date, clinical solutions for this disease have been limited. Mesenchymal stem cells (MSCs), multipotential cells with immune regulation and anti-inflammatory functions, have been applied to treatment of IBD. However, the therapeutic effectiveness of MSCs still needs to be improved. Here, we were interested in whether regulatory T cells (Tregs) could enhance the immune regulation function of MSCs in treatment of mouse colitis...
January 19, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28100093/p19-targeted-abd-derived-protein-variants-inhibit-il-23-binding-and-exert-suppressive-control-over-il-23-stimulated-expansion-of-primary-human-il-17-t-cells
#13
Lucie Křížová, Milan Kuchař, Hana Petroková, Radim Osička, Marie Hlavničková, Ondřej Pelák, Jiří Černý, Tomáš Kalina, Petr Malý
Interleukin-23 (IL-23), a heterodimeric cytokine of covalently bound p19 and p40 proteins, has recently been closely associated with development of several chronic autoimmune diseases such as psoriasis, psoriatic arthritis or inflammatory bowel disease. Released by activated dendritic cells, IL-23 interacts with IL-23 receptor (IL-23R) on Th17 cells, thus promoting intracellular signaling, a pivotal step in Th17-driven pro-inflammatory axis. Here, we aimed to block the binding of IL-23 cytokine to its cell-surface receptor by novel inhibitory protein binders targeted to the p19 subunit of human IL-23...
January 19, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28099821/medication-non-adherence-in-adult-patients-affected-by-inflammatory-bowel-disease-a-critical-review-and-update-of-the-determining-factors-consequences-and-possible-interventions
#14
Marco Vincenzo Lenti, Christian P Selinger
Achieving adherence to medications can be a serious challenge for patients affected by inflammatory bowel disease (IBD). Medical treatment is fundamental for inducing and maintaining remission, preventing flares and reducing the risk of colorectal cancer. Non-adherence may affect patients' quality of life resulting in unfavourable treatment outcomes, more hospitalizations and higher healthcare-related costs. Recognising and improving adherence is therefore a primary aim for the treatment of IBD. Areas covered: We critically discuss the current knowledge on medication non-adherence in adult patients affected by IBD, also mentioning a few issues concerning the paediatric and adolescent populations...
January 18, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28099495/intestinal-bacteria-composition-and-translocation-of-bacteria-in-inflammatory-bowel-disease
#15
Spyros Vrakas, Konstantinos C Mountzouris, George Michalopoulos, George Karamanolis, George Papatheodoridis, Charalampos Tzathas, Maria Gazouli
BACKGROUND: Live commensal intestinal bacteria are present in the peripheral blood where they can induce inflammation. OBJECTIVE: To evaluate the intestinal bacteria composition and translocation of bacteria in IBD. METHODS: Both blood and tissue biopsy samples were collected from adult patients with active/inactive Crohn's disease (CD), active/inactive ulcerative colitis (UC) and healthy individuals. Most of the patients were newly diagnosed and none of them received antibiotics...
2017: PloS One
https://www.readbyqxmd.com/read/28099343/efficacy-and-safety-of-bisphosphonates-in-management-of-low-bone-density-in-inflammatory-bowel-disease-a-meta-analysis
#16
Liwei Yao, Haiqing Wang, Wenwei Dong, Zhenxin Liu, Haijiao Mao
This study aims to determine whether bisphosphonates are safe, as well as effective against bone mineral loss in inflammatory bowel disease (IBD). A computerized search of electronic databases from 1966 to 2016 was performed. Randomized controlled trials (RCTs) were included in this review to evaluate the role of bisphosphonates in the management of osteoporosis in IBD patients. A revised 7-point Jadad scale was used to evaluate the quality of each study. Overall, 13 RCTs and 923 patients met the inclusion criteria of this meta-analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28098389/rosacea-inflammatory-bowel-disease-and-the-value-of-big-data-and-of-epidemiological-studies
#17
C R Meier
No abstract text is available yet for this article.
January 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28096643/intestinal-obstruction-associated-with-ovarian-remnant-in-postmenopausal-female
#18
Ridhima Gupta, Pushpender Gupta
Ovarian remnant syndrome (ORS) is a rare condition, in which the ovarian tissue is inadvertently left behind after difficult oophorectomy. The most common preexisting conditions associated for this complication include endometriosis, pelvic inflammatory disease, and prior abdominal surgery as in these conditions, removal of ovarian tissue becomes difficult. This is likely due to the presence of the dense fibrotic adhesions between an ovary and the surrounding structures. This residual ovarian tissue can become functional and cystic...
October 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28096092/initiation-of-acute-graft-versus-host-disease-by-angiogenesis
#19
Katarina Riesner, Yu Shi, Angela Jacobi, Martin Kraeter, Martina Kalupa, Aleixandria McGearey, Sarah Mertlitz, Steffen Cordes, Jens-Florian Schrezenmeier, Jörg Mengwasser, Sabine Westphal, Daniel Perez-Hernandez, Clemens Schmitt, Gunnar Dittmar, Jochen Guck, Olaf Penack
The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recruitment of tissue infiltrating leukocytes. However, it is not known if angiogenesis has an active role during the initiation of inflammation or if it is merely a secondary effect occurring in response to stimuli by tissue infiltrating leukocytes. Here we show that angiogenesis precedes leukocyte infiltration in experimental models of inflammatory bowel disease and acute graft-versus-host disease (GVHD)...
January 17, 2017: Blood
https://www.readbyqxmd.com/read/28096058/anemia-at-the-time-of-diagnosis-of-inflammatory-bowel-disease-prevalence-and-associated-factors-in-adolescent-and-adult-patients
#20
Alfredo J Lucendo, Ángel Arias, Óscar Roncero, Daniel Hervías, Cristina Verdejo, Carmen Naveas-Polo, Abdelmouneim Bouhmidi, Rufo Lorente, Luis Miguel Alcázar, Irina Salueña, Julio A García-Quiñones, María Jesús Carrillo-Ramos
BACKGROUND: The prevalence, characteristic and determinants of anemia, at the time of inflammatory bowel disease (IBD) diagnosis have yet to be fully elucidated. METHODS: Retrospective cross-sectional study. Analytical data and disease characteristics obtained upon diagnosis of 1278 IBD patients [Crohn's disease/ulcerative colitis (CD/UC): 718/560] were collected. RESULTS: Anemia was present in 41.2% of patients at diagnosis (47% and 33.8% of CD and UC patients, respectively; p<0...
December 14, 2016: Digestive and Liver Disease
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