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https://www.readbyqxmd.com/read/28212924/ibd-immunopathogenesis-a-comprehensive-review-of-inflammatory-molecules
#1
REVIEW
Jae Hyon Park, Laurent Peyrin-Biroulet, Michael Eisenhut, Jae Il Shin
Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic inflammatory conditions of the gastrointestinal tract. Abnormal expressions of pro-and anti-inflammatory molecules have been described to cause an imbalance to the gut innate and adaptive immunity, and recently a large portion of research in IBD has been geared towards identifying novel molecules that may be used as potential therapeutic targets...
February 14, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28212760/psoriasis-and-comorbid-diseases-implications-for-management
#2
REVIEW
Junko Takeshita, Sungat Grewal, Sinéad M Langan, Nehal N Mehta, Alexis Ogdie, Abby S Van Voorhees, Joel M Gelfand
As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chronic kidney disease, inflammatory bowel disease, hepatic disease, certain malignancies, infections, and mood disorders. Recognizing the comorbid disease burden of psoriasis is essential for ensuring comprehensive care of patients with psoriasis...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28212158/an-integrated-understanding-of-the-immunology-of-allograft-inflammation
#3
Brenna Houlihan, Priscilla Cha, Michael Zasloff, Thomas M Fishbein, Alexander Kroemer
PURPOSE OF REVIEW: The purpose of this review is to summarize recent advances in our understanding of the complex immunology of intestinal transplantation and allograft rejection. RECENT FINDINGS: Recent findings highlight the importance of the intestinal microbiome for intestinal homeostasis and the role of newly discovered innate lymphoid cells in intestinal transplantation. In addition, the role of host antimicrobial Th17 responses in the pathogenesis of inflammatory bowel diseases and intestinal allograft rejection has been further elucidated...
February 15, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28211554/psychiatric-illnesses-in-inflammatory-bowel-diseases-psychiatric-comorbidity-and-biological-underpinnings
#4
REVIEW
Jarosław Nowakowski, Adrian Andrzej Chrobak, Dominika Dudek
Inflammatory bowel disease is a group of chronic medical conditions comprising Crohn's disease and ulcerative colitis that involves increased frequency of mental disorders. The most common psychiatric disorders in inflammatory bowel disease are depression and anxiety, however, some epidemiologic and biological evidence suggest that other disorders like bipolar disorder occur more often. Biological mechanisms concerning both inflammatory bowel disease and depression or anxiety explain susceptibility to developing mental disorders in inflammatory bowel disease...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28211537/ambient-ultrafine-particle-ingestion-alters-gut-microbiota-in-association-with-increased-atherogenic-lipid-metabolites
#5
Rongsong Li, Jieping Yang, Arian Saffari, Jonathan Jacobs, Kyung In Baek, Greg Hough, Muriel H Larauche, Jianguo Ma, Nelson Jen, Nabila Moussaoui, Bill Zhou, Hanul Kang, Srinivasa Reddy, Susanne M Henning, Matthew J Campen, Joseph Pisegna, Zhaoping Li, Alan M Fogelman, Constantinos Sioutas, Mohamad Navab, Tzung K Hsiai
Ambient particulate matter (PM) exposure is associated with atherosclerosis and inflammatory bowel disease. Ultrafine particles (UFP, dp < 0.1-0.2 μm) are redox active components of PM. We hypothesized that orally ingested UFP promoted atherogenic lipid metabolites in both the intestine and plasma via altered gut microbiota composition. Low density lipoprotein receptor-null (Ldlr(-/-)) mice on a high-fat diet were orally administered with vehicle control or UFP (40 μg/mouse/day) for 3 days a week...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211161/psoriasis-and-psoriasiform-eruptions-in-pediatric-patients-with-inflammatory-bowel-disease-treated-with-anti-tumor-necrosis-factor-alpha-agents
#6
Joshua B Eickstaedt, Luke Killpack, Jeanne Tung, Dawn Davis, Jennifer L Hand, Megha M Tollefson
BACKGROUND: Anti-tumor necrosis factor alpha (TNF-α) agents are used to treat a variety of autoimmune and inflammatory conditions, including psoriasis. Paradoxically, numerous reports have documented new-onset or exacerbation of psoriasis or psoriasiform skin lesions (PSO) in patients treated with these agents for conditions other than PSO-particularly in adults with inflammatory bowel disease (IBD). Not much is known regarding similar cases in children. METHODS: A retrospective chart review was performed on children younger than 19 years of age with IBD seen at the Mayo Clinic between 2003 and 2015 who developed new-onset or recurrent PSO while undergoing anti-TNF-α therapy...
February 17, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28210836/clostridium-difficile-infection-in-inflammatory-bowel-disease-challenges-in-diagnosis-and-treatment
#7
REVIEW
Ying M Tang, Christian D Stone
The problem of Clostridium difficile infection (CDI) has reached epidemic proportions, particularly in industrialized nations. The pathophysiology, disease course and the potential complications are well appreciated in the general hospitalized patient. However, when CDI occurs in the setting of inflammatory bowel disease (IBD), a number of distinct differences in the diagnosis and clinical management of the infection in this population should be appreciated by gastroenterologists, hospitalists and other care providers...
February 16, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28210767/crohn-s-disease-diagnosis-treatment-approach-and-management-paradigm-what-the-radiologist-needs-to-know
#8
Parakkal Deepak, Sang Hyoung Park, Eric C Ehman, Stephanie L Hansel, Jeff L Fidler, David H Bruining, Joel G Fletcher
Crohn's disease is one of the major subtypes of idiopathic inflammatory bowel disease and is characterized by chronic transmural intestinal inflammation of the gastrointestinal tract anywhere from mouth to the anus, with a predilection for the small bowel. Cross-sectional imaging with computed tomography and magnetic resonance enterography plays a key role in confirming diagnosis, identifying and managing complications, assessing disease severity, and identifying response to medical therapy. This review will focus on the role of radiologists in the diagnosis and assessment of Crohn's disease...
February 16, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28210706/single-balloon-enteroscopy-efficacy-and-degree-of-concordance-with-noninvasive-evaluation-of-small-bowel
#9
Margarida Marques, João Antunes, Rosa Coelho, Hélder Cardoso, Filipe Vilas Boas, Armando Ribeiro, Guilherme Macedo
Background and study aims Clinical impact of single-balloon enteroscopy (SBE) is fairly known, as well as its diagnostic yield comparing with other small bowel gastrointestinal investigations. This study represents a contribution to better understand it and is designed to evaluate SBE efficacy and degree of concordance with previous evaluation of small bowel. Patients and methods This is a single-center retrospective study of patients that underwent SBE with suspected small bowel disease based on non-invasive imaging...
February 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28210079/%C3%AE-2-heremans-schmid-glycoprotein-fetuin-a-downregulation-and-its-utility-in-inflammatory-bowel-disease
#10
Anastassios C Manolakis, Gregory Christodoulidis, Andreas N Kapsoritakis, Panagiotis Georgoulias, Elisavet K Tiaka, Kostas Oikonomou, Varvara J Valotassiou, Spyros P Potamianos
AIM: To investigate the impact of inflammatory bowel disease (IBD) on α2-Heremans-Schmid Glycoprotein (AHSG/fetuin A) and potential associations with disease and patient characteristics. METHODS: AHSG serum levels were determined in treatment-naïve newly-diagnosed patients, 96 with ulcerative colitis (UC), 84 with Crohn's disease (CD), 62 with diarrhea-predominant or mixed irritable bowel syndrome (IBS, D- and M- types) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA)...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28210077/clinical-impact-of-immunomonitoring-in-the-treatment-of-inflammatory-bowel-disease
#11
REVIEW
Donal Tighe, Deirdre McNamara
Despite improvement in outcomes, loss of response (LOR) to tumor necrosis factor-alpha (TNFα) therapies is a big concern in the management of inflammatory bowel disease. LOR is associated with flares of disease, increased hospitalisation rates, need for surgical interventions, and decline in quality of life. LOR may be multifactorial, but immunogenicity makes a significant contribution. Traditionally doses of anti-TNFα have been adjusted based on clinical response, using a standard approach. Immunomonitoring involves the measurement of anti-TNFα trough and antibody levels...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28210071/update-on-the-medical-management-of-gastrointestinal-beh%C3%A3-et-s-disease
#12
REVIEW
Giuseppe Lopalco, Donato Rigante, Vincenzo Venerito, Claudia Fabiani, Rossella Franceschini, Michele Barone, Giovanni Lapadula, Mauro Galeazzi, Bruno Frediani, Florenzo Iannone, Luca Cantarini
Behçet's disease (BD) is a multisystemic disorder of unknown etiology mainly defined by recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis, all of which represent the "stigmata" of disease. However, many other organs including the vascular, neurological, musculoskeletal, and gastrointestinal systems can be affected. The gastrointestinal involvement in Behçet's disease (GIBD), along with the neurological and vascular ones, represents the most feared clinical manifestation of BD and shares many symptoms with inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28209676/what-is-hidradenitis-suppurativa
#13
REVIEW
Erika Yue Lee, Raed Alhusayen, Perla Lansang, Neil Shear, Jensen Yeung
OBJECTIVE: To provide family physicians with an understanding of the epidemiology, clinical features, diagnosis, and management of hidradenitis suppurativa (HS). SOURCES OF INFORMATION: A PubMed literature search was performed using the MeSH term hidradenitis suppurativa. MAIN MESSAGE: Hidradenitis suppurativa is a chronic, recurrent, and debilitating skin condition. It is an inflammatory disorder of the follicular epithelium, but secondary bacterial infection can often occur...
February 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28209014/pyostomatitis-vegetans-a-clue-for-diagnosis-of-silent-crohn-s-disease
#14
Saede Atarbashi-Moghadam, Ali Lotfi, Fazele Atarbashi-Moghadam
Pyostomatitis vegetans is a very rare oral manifestation with unknown pathogenesis. Skin and other mucous membrane involvement may be seen. This lesion has strong association with Inflammatory Bowel Disease (IBD) and may be the first sign of it. The management of Pyostomatitis vegetans is usually based on the management of underlying bowel disease. We present a case of Pyostomatitis vegetans involving gingiva and oral mucosa with no skin lesion which led to the diagnosis of Crohn's disease to emphasize important role of dentists in diagnosis of rare oral lesions and management of patients' systemic disease...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208008/disability-due-to-inflammatory-bowel-disease-is-correlated-with-drug-compliance-disease-activity-and-quality-of-life
#15
Jin Young Yoon, Jeong Eun Shin, Sang Hyoung Park, Dong Il Park, Jae Myung Cha
Background/Aims: The inflammatory bowel disease disability index (IBD-DI) was recently developed for IBD to assess the functional consequences and disease burden. We applied the IBD-DI to a Korean population and identified predictive factors influencing IBD-related disability. Methods: Between March and August 2015, 322 consecutive patients with IBD were prospectively recruited. Patients completed the IBD-DI questionnaire and Crohn's and Ulcerative Colitis Questionnaire (CUCQ-8) for assessing quality of life...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28208007/risk-factors-for-vitamin-d-zinc-and-selenium-deficiencies-in-korean-patients-with-inflammatory-bowel-disease
#16
Yoo Min Han, Hyuk Yoon, Soo Lim, Mi-Kyung Sung, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee, Joo Sung Kim
Background/Aims: Studies on the micronutrient status of Asian patients with inflammatory bowel disease (IBD) are scarce. We evaluated the prevalence of micronutrient deficiency and verified the risk factors for micronutrient deficiency in Korean patients with IBD. Methods: We measured the serum levels of 25-hydroxyvitamin D3 [25-(OH)D], zinc, and selenium to analyze the clinical risk factors for micronutrient levels below the reference values. In addition, we compared the 25-(OH)D levels of patients with IBD to those of age- and sex-matched healthy controls...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28207475/temporal-trend-of-pediatric-inflammatory-bowel-disease-analysis-of-national-registry-data-2004-2013-in-japan
#17
Takashi Ishige, Takeshi Tomomasa, Reiko Hatori, Maiko Tatsuki, Yoshiko Igarashi, Kazuhiko Sekine, Hirokazu Arakawa
Increased incidence and prevalence of pediatric inflammatory bowel disease (IBD) have been reported in Western countries. However, changes in the prevalence of pediatric IBD in Asian countries remain unclear. We evaluated the changes in the prevalence of IBD among Japanese adults and children from 2004-2013, by using the Japanese national registry data of patients receiving financial aid. Data from children (aged 0-19 years) were compared with those from young adults (aged 20-39 years).In 2004, age-standardized prevalences of CD and UC among children were 4...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28207474/risk-of-colectomy-in-patients-with-pediatric-onset-ulcerative-colitis
#18
Firas Rinawi, Amit Assa, Rami Eliakim, Yael Mozer Glassberg, Vered Nachmias Friedler, Yaron Niv, Yoram Rosenbach, Ari Silbermintz, Noam Zevit, Raanan Shamir
OBJECTIVES: Data describing the incidence and risk factors for colectomy in pediatric ulcerative colitis (UC) is inconsistent. Our aim was to describe the colectomy rate and to identify risk factors associated with colectomy in a large cohort of children with UC with long term follow up. METHODS: We performed a retrospective chart review of pediatric UC cases that were diagnosed at Schneider Children's Medical Center of Israel between 1981 to 2013. Potential predictors for colectomy including age at diagnosis, gender, disease extent, severity indices and different therapeutic regimens during disease course were assessed...
February 15, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28207290/fatty-acid-and-mineral-receptors-as-drug-targets-for-gastrointestinal-disorders
#19
Pawin Pongkorpsakol, Aekkacha Moonwiriyakit, Chatchai Muanprasat
Nutrient-sensing receptors, including fatty acid receptors (FFA1-FFA4), Ca(2+)-sensing receptors and Zn(2+)-sensing receptors, are involved in several biological processes. These receptors are abundantly expressed in the GI tract, where they have been shown to play crucial roles in regulating GI function. This review provides an overview of the GI functions of fatty acid and mineral receptors, including the regulation of gastric and enteroendocrine functions, GI motility, ion transport and cell growth. Recently, several lines of evidence have implicated these receptors as promising therapeutic targets for the treatment of GI disorders, for example, inflammatory bowel disease, colorectal cancer, metabolic syndrome and diarrheal diseases...
February 16, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28206918/y-type-anovulvar-fistula-complicating-inflammatory-bowel-disease
#20
Georgios-Marios Makris, Anestis Charalampopoulos, Charalampos Siristatidis, Dimitra Fexi, Charalampos Chrelias, Marco-Johannes Battista, Nikolaos Papantoniou
No abstract text is available yet for this article.
November 1, 2016: American Surgeon
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