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JOURNAL ARTICLE
Zainab M A Al Radi, Femke M Prins, Valerie Collij, Arnau Vich Vila, Eleonora A M Festen, Gerard Dijkstra, Rinse K Weersma, Marjolein A Y Klaassen, Ranko Gacesa
BACKGROUND: Inflammatory bowel diseases (IBDs) pose a significant challenge due to their diverse, often debilitating, and unpredictable clinical manifestations. The absence of prognostic tools to anticipate the future complications that require therapy intensification presents a substantial burden to patient private life and health. We aimed to explore whether the gut microbiome is a potential biomarker for future therapy intensification in a cohort of 90 IBD patients. METHODS: We conducted whole-genome metagenomics sequencing on fecal samples from these patients, allowing us to profile the taxonomic and functional composition of their gut microbiomes...
April 18, 2024: Inflammatory Bowel Diseases
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JOURNAL ARTICLE
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JOURNAL ARTICLE
Helen Burton-Murray, Katheryn Kiser, Jenny Gurung, Katherine Williams, Jennifer J Thomas, Hamed Khalili
BACKGROUND AND AIM: Recent studies have shown that up to 53% of patients with inflammatory bowel disease (IBD) screen positive for avoidant/restrictive food intake disorder (ARFID). There is however concern that ARFID screening rates are over-inflated in patients with active disease. We aimed to evaluate the frequency and characteristics of ARFID symptoms using the Nine Item ARFID Screen (NIAS), and to use another eating disorder measure, the Eating Disorder Examination-Questionnaire 8 (EDE-Q8), to rule-out/characterize other eating disorder cognitive and behavioral symptoms...
April 18, 2024: Journal of Crohn's & Colitis
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REVIEW
Ryan Xin
Inflammatory bowel disease (IBD) is a complex disease that develops through a sequence of molecular events that are still poorly defined. This process is driven by a multitude of context-dependent genes that play different roles based on their environment. The complexity and multi-faceted nature of these genes make it difficult to study the genetic basis of IBD. The goal of this article is to review the key genes in the pathophysiology of IBD and highlight new technology that can be used in further research...
April 18, 2024: Molecular Diagnosis & Therapy
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JOURNAL ARTICLE
Flor M Fernández-Gordón Sánchez, Celia Gómez Labrador, Luis Wong Becerra, Bairon Alfoso Paz Fernández, Ana Patricia Martínez Aguilar, Carlos Castaño-Milla
Microscopic colitis is a form of chronic and recurrent inflammatory bowel disease characterized by non-bloody, watery diarrhea, macroscopically normal colonic mucosa, and characteristic histopathological findings. Some drugs have been described as triggers of colonic inflammation in predisposed individuals, while others may exacerbate microscopic colitis that evolves on its own. We present the case of a patient diagnosed with active microscopic colitis in relation to taking fluoxetine at high doses.
April 18, 2024: Revista Española de Enfermedades Digestivas
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JOURNAL ARTICLE
David Beaton, Linda Sharp, Liya Lu, Nigel Trudgill, Mo Thoufeeq, Brian Nicholson, Peter Rogers, James Docherty, Anna Jenkins, A John Morris, Thomas Rösch, Matthew Rutter
BACKGROUND: The value of lower gastrointestinal endoscopy (LGIE; colonoscopy or sigmoidoscopy) relates to its ability to detect clinically relevant findings, predominantly cancers, preneoplastic polyps or inflammatory bowel disease. There are concerns that many LGIEs are performed on low-risk patients with limited benefit. AIMS: To determine the diagnostic outcomes of LGIE for common symptoms. METHODS: We performed a cross-sectional study of diagnostic LGIE between March 2019 and February 2020 using the UK National Endoscopy Database...
April 18, 2024: Alimentary Pharmacology & Therapeutics
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REVIEW
Changlin Wen, Dan Chen, Rao Zhong, Xi Peng
Inflammatory bowel disease (IBD) research often relies on animal models to study the etiology, pathophysiology, and management of IBD. Among these models, rats and mice are frequently employed due to their practicality and genetic manipulability. However, for studies aiming to closely mimic human pathology, non-human primates such as monkeys and dogs offer valuable physiological parallels. Guinea pigs, while less commonly used, present unique advantages for investigating the intricate interplay between neurological and immunological factors in IBD...
2024: Gastroenterology Report
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JOURNAL ARTICLE
Seung Yeob Yu, Byeong Seob Oh, Seoung Woo Ryu, Jeong Eun Bak, Eun Seo Heo, Jeong Chan Moon, Jae-Ho Jeong, Ju Huck Lee
A novel Gram-negative, obligate anaerobe, non-motile, flagella-lacking, catalase- and oxidase-negative, coccobacilli-shaped bacterial strain designated AGMB02718T was isolated from swine feces. The 16S rRNA gene analysis indicated that strain AGMB02718T belonged to the genus Mesosutterella with the highest similarity to M. multiformis 4NBBH2T (= DSM 106860T ) (sequence similarity of 96.2%), forming a distinct phylogenetic lineage. Its growth occurred at 25-45°C (optimal 37°C) and in 0.5-1% NaCl (optimal 0...
2024: Frontiers in Microbiology
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JOURNAL ARTICLE
Sara Gostoli, Francesco Ferrara, Ludovica Quintavalle, Sara Tommasino, Graziano Gigante, Maria Montecchiarini, Alessia Urgese, Francesco Guolo, Regina Subach, Angelica D'Oronzo, Annamaria Polifemo, Federica Buonfiglioli, Vincenzo Cennamo, Chiara Rafanelli
Psychological characterization of patients affected by Inflammatory Bowel Disease (IBD) focuses on comorbidity with psychiatric disorders, somatization or alexithymia. Whereas IBD patients had higher risk of stable anxiety and depression for many years after the diagnosis of the disease, there is a lack of studies reporting a comprehensive psychosomatic assessment addressing factors of disease vulnerability, also in the long-term. The objective of this investigation is to fill this gap in the current literature...
April 17, 2024: BMC Psychology
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REVIEW
Mari Murakami
Tissue-resident memory T cells (TRM ) serve as the frontline of host defense, playing a critical role in protection against invading pathogens. This emphasizes their role in providing rapid on-site immune responses across various organs. The physiological significance of TRM is not just confined to infection control; accumulating evidence has revealed that TRM also determine the pathology of diseases such as autoimmune disorders, inflammatory bowel disease, and cancer. Intensive studies on the origin, mechanisms of formation and maintenance, and physiological significance of TRM have elucidated the transcriptional and functional diversity of these cells, which are often affected by local cues associated with their presence...
April 17, 2024: Inflammation and Regeneration
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JOURNAL ARTICLE
Wu Ronghua, Zheng Ji, Liu Gang, Zhang Yun, Nie Xubiao
•we report the case of a 36-year-old female patient who presented to our hospital with a diagnosis of cystitis glandularis manifesting as a vesicovaginal fistula. She underwent cystoscopic biopsy at a local hospital, but anti-inflammatory treatment was ineffective, and the patient was experiencing low urination frequency and urgency, as well as pain. The patient underwent laparoscopic repair of a cystoscopy-confirmed vesicovaginal fistula. After surgery, the patient experienced a paroxysm of Crohn's disease with multiple small bowel fistulas and erosion of the external iliac vessels that ruptured to form an external iliac vessel small bowel fistula...
April 17, 2024: BMC Urology
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JOURNAL ARTICLE
Mu-Ming Chien, Mei-Hwei Chang, Kai-Chi Chang, Yen-Hsuan Ni, Jia-Feng Wu
BACKGROUND: The incidence of Clostridium difficile infection (CDI) is increasing around the world, and patients with inflammatory bowel disease (IBD) have a higher risk of obtaining CDI. The data on the incidence rate of CDI in the Asian pediatric IBD population was lacking. METHODS: We retrospectively collected data from a tertiary medical center in Taipei, Taiwan. All patients aged 1-18 years old who visited the outpatient department or were admitted to our hospital between 2006 and 2019 were included...
April 16, 2024: Journal of the Formosan Medical Association
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JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
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JOURNAL ARTICLE
Morris Gordon, Jamal Khudr, Vassiliki Sinopoulou, Svetlana Lakunina, Aditi Rane, Anthony Akobeng
OBJECTIVE: Our objective was to perform a systemic evaluation of the risk of bias in randomised controlled trial (RCT) reports published on inflammatory bowel disease (IBD). DESIGN: We assessed the risk of bias using the Cochrane tool, as indicators of poor methodology or subsequently poor reporting. We systematically selected, with dual independent judgements, all studies published on IBD with no time limits and assessed the methodological quality of included studies again using independent dual ratings...
April 17, 2024: BMJ Open Gastroenterology
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JOURNAL ARTICLE
Andrea N Simpson, Rinku Sutradhar, Eric I Benchimol, Wing C Chan, Joan Porter, Sarah Moore, Fahima Dossa, Vivian Huang, Cynthia Maxwell, Laura Targownik, Ning Liu, Nancy N Baxter
OBJECTIVE: It is unclear if use of cesarean delivery in people with inflammatory bowel disease (IBD) is guideline-concordant. We compared the odds of cesarean delivery among primiparous individuals with IBD versus without, overall and by disease characteristics, as well as time to subsequent delivery. METHODS: Retrospective matched population-based cohort study between 1 April 1994 and 31 March 2020. Primiparous individuals aged 15-55 years with IBD were matched to those without on age, year, hospital, and number of newborns delivered...
April 15, 2024: Journal of Obstetrics and Gynaecology Canada: JOGC
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JOURNAL ARTICLE
Andreas Zollner, Robert Koch, Almina Jukic, Alexandra Pfister, Moritz Meyer, Nikolaus Wick, Georg Wick, Annika Rössler, Janine Kimpel, Timon E Adolph, Herbert Tilg
No abstract text is available yet for this article.
April 15, 2024: Gastroenterology
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JOURNAL ARTICLE
Devendra Paudel, Divek V T Nair, Sangshan Tian, Fuhua Hao, Umesh K Goand, Grace Joseph, Eleni Prodes, Zhi Chai, Chloé E M Robert, Benoit Chassaing, Andrew D Patterson, Vishal Singh
With an increasing interest in dietary fibers (DFs) to promote intestinal health and the growth of beneficial gut bacteria, there is a continued rise in the incorporation of refined DFs in processed foods. It is still unclear how refined fibers, such as guar gum, affect the gut microbiota activity and pathogenesis of inflammatory bowel disease (IBD). Our study elucidated the effect and underlying mechanisms of guar gum, a fermentable DF (FDF) commonly present in a wide range of processed foods, on colitis development...
2024: Gut Microbes
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JOURNAL ARTICLE
Lilang Li, Xiang Zhang, Li Wang, Ming Gao, Yu Wang, Zhengrong Zhang, Xiaosheng Yang, Juan Yang
BACKGROUND: Ulcerative colitis (UC) refers to an idiopathic chronic inflammatory bowel disease that start with inflammation of the intestinal mucosa. Dietary fiber plays a crucial role in maintaining the normal architecture of the intestinal mucosa. In this study, the protective effect and potential mechanism of soluble dietary fiber from Rosa roxburghii Tratt residue (SDFR) on dextran sulfate sodium (DSS)-induced UC mice were explored. RESULTS: The results revealed that SDFR could ameliorate the body weight loss and pathological injury, improve the structure and crypt destruction in colon in DSS-induced mice...
April 17, 2024: Journal of the Science of Food and Agriculture
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JOURNAL ARTICLE
Laura Vekara, Saija Kantanen, Kaija-Leena Kolho, Kati Räsänen, Timo Lakka, Heini Huhtala, Eija Piippo-Savolainen, Pekka Arikoski, Pauliina Hiltunen
OBJECTIVES: Prior studies on the psychological well-being in pediatric inflammatory bowel disease (PIBD) have reported controversial results. Our aim was to compare the psychological well-being and lifestyle factors in patients with PIBD and their controls and to assess the role of contributing disease characteristics. METHODS: This cross-sectional study included 60 PIBD patients aged 6-17 years (26 with Crohn's disease [CD], 34 with ulcerative colitis [CD] or unclassified colitis [IBD-U]) from two university hospitals in Finland, and their age- and sex-matched healthy controls...
April 17, 2024: Journal of Pediatric Gastroenterology and Nutrition
#20
JOURNAL ARTICLE
Lili You, Siyao Wang, Yangyang Wang, Lingling Zhu, Tiantian Wang, Xiang Yu, Jing Dong, Yuxia Guan
AIM: To explore factors promoting and hindering resilience in youth with inflammatory bowel disease (IBD) based on Kumpfer's resilience framework. DESIGN: A descriptive qualitative study design with an interpretative approach was used. METHODS: Participants consisted of 10 youths with IBD from a tertiary hospital in Beijing (China) recruited using the purposive sampling method. Data were collected by semi-structured interviews from December 2020 to March 2021...
April 2024: Nursing Open
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