Ji Hee Ha, Rangasudhagar Radhakrishnan, Revathy Nadhan, Rohini Gomathinayagam, Muralidharan Jayaraman, Mingda Yan, Srishti Kashyap, Kar-Ming Fung, Chao Xu, Resham Bhattacharya, Priyabrata Mukherjee, Ciro Isidoro, Yong Sang Song, Danny N Dhanasekaran
Ovarian cancer ranks as a leading cause of mortality among gynecological malignancies, primarily due to the lack of early diagnostic tools, effective targeted therapy, and clear understanding of disease etiology. Previous studies have identified the pivotal role of Lysophosphatidic acid (LPA)-signaling in ovarian cancer pathobiology. Our earlier transcriptomic analysis identified Urothelial Carcinoma Associated-1 (UCA1) as an LPA-stimulated long non-coding RNA (lncRNA). In this study, we elucidate the tripartite interaction between LPA-signaling, UCA1, and let-7 miRNAs in ovarian cancer progression...
April 18, 2024: Cancer Letters