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https://www.readbyqxmd.com/read/29351547/mortality-and-continuity-of-care-definitions-matter-a-cohort-study-in-diabetics
#1
Angelika Geroldinger, Simone Katja Sauter, Georg Heinze, Gottfried Endel, Wolfgang Dorda, Georg Duftschmid
OBJECTIVE: To demonstrate that when investigating the relevance of continuity of care for patient outcomes, different definitions can lead to contradicting results. METHODS: We used claims data from the regional public health insurer of Lower Austria covering the period from 2008 to 2011. The study sample included subjects with repeated dispensings of anti-diabetic drugs. The continuity of care index was calculated firstly based on a patient's contacts with general practitioners (primary COCI) and secondly based on contacts at all medical disciplines (total COCI)...
2018: PloS One
https://www.readbyqxmd.com/read/29350569/practice-pearl-liraglutide-and-cardiovascular-and-renal-events-in-type-2-diabetes
#2
Robert Guthrie
Review of: Marso S, Daniels G, Brown-Frandsen K, et al. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med 2016; 375: 311-322. Mann J, Orsted D, Brown-Frandsen K, et al. Liraglutide and Renal Outcomes in Type 2 Diabetes. N Engl J Med 2017; 377: 839-848. This comprehensive research project, LEADER, led to two reports, one focusing on the effect of liraglutide on cardiovascular events, and the second one reporting on the renal effects on the same study population. The study group included 9340 patients with type 2 diabetes...
January 19, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29350465/proteomics-analysis-of-skeletal-muscle-from-leptin-deficient-ob-ob-mice-reveals-adaptive-remodeling-of-metabolic-characteristics-and-fiber-type-composition
#3
Milena Schönke, Marie Björnholm, Alexander V Chibalin, Juleen R Zierath, Atul S Deshmukh
Skeletal muscle insulin resistance, an early metabolic defect in the pathogenesis of type 2 diabetes, may be a cause or consequence of altered protein expressions profiles. Proteomics technology offers enormous promise to investigate molecular mechanisms underlying pathologies, however, the analysis of skeletal muscle is challenging. Using state-of-the-art multi-enzyme digestion and filter-aided sample preparation (MED-FASP) and a mass spectrometry (MS) based workflow, we performed a global proteomics analysis of skeletal muscle from leptin-deficient, obese, insulin resistant (ob/ob) and lean mice in mere two fractions in a short time (8 hours/sample)...
January 19, 2018: Proteomics
https://www.readbyqxmd.com/read/29350063/a-qualitative-interview-study-of-people-living-with-well-controlled-type-1-diabetes
#4
Debbie M Smith, Peter J Donnelly, John Howe, Terry Mumford, Alan Campbell, Angela Ruddock, Stephanie Tierney, Alison Wearden
OBJECTIVE: While many people with Type 1 diabetes find it difficult to achieve recommended blood glucose levels, a minority do achieve good control. Our study was conceived by patient and public (PP) partners and sought to learn about experiences of people living with well-controlled diabetes. DESIGN: A collaboration between academic health psychologists and five PP partners with experience of diabetes, who were trained to conduct and analyse semi-structured interviews...
January 19, 2018: Psychology & Health
https://www.readbyqxmd.com/read/29349888/distal-amyloid-%C3%AE-protein-fragments-template-amyloid-assembly
#5
Thanh D Do, Smriti Sangwan, Natália E C de Almeida, Alexandre I Ilitchev, Maxwell Giammona, Michael R Sawaya, Steven K Buratto, David S Eisenberg, Michael T Bowers
Amyloid formation is associated with devastating diseases such as Alzheimer's, Parkinson's and Type-2 diabetes. The large amyloid deposits found in patients suffering from these diseases have remained difficult to probe by structural means. Recent NMR models also predict heterotypic interactions from distinct peptide fragments but limited evidence of heterotypic packed sheets is observed in solution. Here we characterize two segments of the protein amyloid β (Aβ) known to form fibrils in Alzheimer's disease patients...
January 19, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29349876/effectiveness-of-a-body-shape-index-absi-in-predicting-chronic-diseases-and-mortality-a-systematic-review-and-meta-analysis
#6
REVIEW
M Ji, S Zhang, R An
Anthropometric measures are simple, inexpensive, noninvasive tools to assess the risk of morbidity and mortality. This systematic review assessed the performance of A Body Shape Index (ABSI) in predicting hypertension, cardiovascular disease, type 2 diabetes and all-cause mortality and compared the differential predictability between ABSI and two other common anthropometric measures - body mass index and waist circumference. A keyword and reference search were conducted in the PubMed and Web of Science for articles published until 1 November 2017...
January 19, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29348994/the-association-of-mediterranean-diet-and-exercise-modifications-with-anthropometric-parameters-in-a-psychiatric-community-population-a-pilot-study
#7
Rosaria Di Lorenzo, Jessica Pedretti, Letizia Grossi, Benedetta Cuoghi, Cinzia Varni, Giulia Landi, Ludovica Spattini, Chiara Visentini, Paola Ferri, Francesca Carubbi
Weight gain and related metabolic syndrome (MS) are major current issues in public health. MS consists of abdominal fat, atherogenic dyslipidemia, hypertension, hyperglycemia, insulin resistance, pro-inflammatory and pro-thrombotic state, and accounts for both cardiovascular diseases and type II diabetes mellitus risk factors. Patients affected by psychiatric illness present a prevalence of 35-40% of MS. Many studies have shown that Mediterranean diet is associated with the reduction of mortality due to cardiovascular and malignant diseases, potentially preventing both obesity and type II diabetes mellitus...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29348496/natriuretic-peptides-promote-glucose-uptake-in-a-cgmp-dependent-manner-in-human-adipocytes
#8
Marine Coué, Valentin Barquissau, Pauline Morigny, Katie Louche, Corinne Lefort, Aline Mairal, Christian Carpéné, Nathalie Viguerie, Peter Arner, Dominique Langin, Mikael Rydén, Cedric Moro
Robust associations between low plasma level of natriuretic peptides (NP) and increased risk of type 2 diabetes (T2D) have been recently reported in humans. Adipose tissue (AT) is a known target of NP. However it is unknown whether NP signalling in human AT relates to insulin sensitivity and modulates glucose metabolism. We here show in two European cohorts that the NP receptor guanylyl cyclase-A (GC-A) expression in subcutaneous AT was down-regulated as a function of obesity grade while adipose NP clearance receptor (NPRC) was up-regulated...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348381/thyroid-dysfunction-in-type-2-diabetes-mellitus-patients
#9
Imam Subekti, Laurentius Aswin Pramono, Esthika Dewiasty, Dante Saksono Harbuwono
BACKGROUND: thyroid dysfunction is more likely to occur in diabetes mellitus patients than general population. Until now, no study has been done to find prevalence of hypothyroidism and hyperthyroidism in Indonesian diabetics. This study aimed to find the proportion and characteristics of thyroid dysfunction in Indonesian type 2 diabetes mellitus patients. METHODS: a cross-sectional study was conducted in Endocrine and Diabetes Polyclinic, Department of Internal Medicine, Cipto Mangunkusumo Hospital from July to September 2015...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29348194/health-care-costs-associated-with-incident-complications-in-patients-with-type-2-diabetes-in-germany
#10
Katharina Kähm, Michael Laxy, Udo Schneider, Wolf H Rogowski, Stefan K Lhachimi, Rolf Holle
OBJECTIVE: The aim of this study is to provide reliable regression-based estimates of costs associated with different type 2 diabetes complications. RESEARCH DESIGN AND METHODS: We used nationwide statutory health insurance (SHI) data from 316,220 patients with type 2 diabetes. Costs for inpatient and outpatient care, pharmaceuticals, rehabilitation, and nonmedical aids and appliances were assessed in the years 2013-2015. Quarterly observations are available for each year...
January 18, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29347857/mulberry-leaves-and-their-potential-effects-against-cardiometabolic-risks-a-review-of-chemical-compositions-biological-properties-and-clinical-efficacy
#11
Thanchanit Thaipitakwong, Surawej Numhom, Pornanong Aramwit
CONTEXT: Cardiometabolic risks are regarded as the crucial factors associated with type 2 diabetes (T2DM) and cardiovascular diseases (CVD). Regarding an increased attention to medicinal plants in the current healthcare system, the effects of mulberry (Morus spp., Moraceae) leaves on cardiometabolic risks have been consecutively considered in scientific research. OBJECTIVE: The present review compiles and summarizes the chemical compositions, biological properties and clinical efficacy of mulberry leaves that are related to the amelioration of cardiometabolic risks...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29347844/docking-analysis-targeted-to-the-whole-enzyme-an-application-to-the-prediction-of-inhibition-of-ptp1b-by-thiomorpholine-and-thiazolyl-derivatives
#12
C A Ganou, P Th Eleftheriou, P Theodosis-Nobelos, M Fesatidou, A A Geronikaki, T Lialiaris, E A Rekka
PTP1b is a protein tyrosine phosphatase involved in the inactivation of insulin receptor. Since inhibition of PTP1b may prolong the action of the receptor, PTP1b has become a drug target for the treatment of type II diabetes. In the present study, prediction of inhibition using docking analysis targeted specifically to the active or allosteric site was performed on 87 compounds structurally belonging to 10 different groups. Two groups, consisting of 15 thiomorpholine and 10 thiazolyl derivatives exhibiting the best prediction results, were selected for in vitro evaluation...
February 2018: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/29345498/effects-of-blueberry-and-cranberry-consumption-on-type-2-diabetes-glycemic-control-a-systematic-review
#13
Dmup Rocha, Aps Caldas, Bp da Silva, Hh Hermsdorff, Rcg Alfenas
The metabolic effects of cranberry and blueberry consumption on glycemic control have been evaluated in vitro and in animal models as well as in human studies, although findings have not been systematically reviewed yet. Therefore, a systematic review was carried out of relevant randomized clinical trials (RCTs) in order to assess the effect of berries (blueberry and cranberry) consumption on type 2 diabetes (T2DM) glycemic control. Some evidences were also discussed on the anti-diabetic mechanisms exerted by berries polyphenols...
January 18, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29345464/whole-egg-consumption-exerts-a-nephroprotective-effect-in-an-acute-rodent-model-of-type-1-diabetes
#14
Cassondra J Saande, Samantha K Jones, Matthew J Rowling, Kevin L Schalinske
Nephropathy is a well-characterized complication of type 1 diabetes (T1D), resulting in proteinuria and urinary loss of micronutrients. We previously found that a whole egg-based diet maintained vitamin D balance in type 2 diabetic rats despite excessive urinary losses due to nephropathy. The goal of this study was to investigate the impact of whole egg consumption in T1D rats. Sprague-Dawley rats were randomly assigned to T1D or nondiabetic control groups and fed a casein or whole egg-based diet for 32 days...
January 18, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29344829/rapid-acting-and-regular-insulin-are-equal-for-high-fat-protein-meal-in-individuals-with-type-1-diabetes-treated-with-multiple-daily-injections
#15
Karolina Jabłońska, Piotr Molęda, Krzysztof Safranow, Lilianna Majkowska
INTRODUCTION: The fat and protein content can impact late postprandial glycemia; therefore, prolonged insulin boluses for high-fat/-protein meals are recommended for patients with type 1 diabetes on insulin pump therapy. It is not clear how to translate these findings to multiple daily injection (MDI) therapy. We hypothesized that regular insulin with a slower onset and a longer duration of action might be advantageous for such meals. METHODS: Twenty-five patients with well-controlled type 1 diabetes (mean HbA1c 6...
January 17, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29344534/the-effect-of-self-care-education-on-emotional-intelligence-and-hba1c-level-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-clinical-trial
#16
Salma Tavakol Moghadam, Seyed Saeed Najafi, Shahrzad Yektatalab
Background: The role of Emotional Intelligence (EI) in glycemic control in type 2 Diabetes Mellitus (DM) has not been fully understood. The present study aimed to investigate the effect of self-care education on EI and hemoglobin glycosylated (HbA1c) in patients with type 2 diabetes. Methods: In this randomized controlled clinical trial, 48 patients with type 2 DM referred to Shahid Motahari Diabetes Center in 2015 were divided into an intervention and a control group using block randomization...
January 2018: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29344329/major-adverse-cardiovascular-event-reduction-with-glp-1-and-sglt2-agents-evidence-and-clinical-potential
#17
REVIEW
Michael E Røder
Treatment of patients with type 2 diabetes is directed against treating symptoms of hyperglycemia, minimizing the risk of hypoglycemia, and the risk of microvascular and macrovascular complications. The majority of patients with type 2 diabetes die from cardiovascular or cerebrovascular disease. Future therapies should therefore focus on reducing cardiovascular morbidity in this high-risk population. Glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose co-transporter 2 inhibitors (SGLT2-i) are two drug classes with proven antihyperglycemic effect in type 2 diabetes...
January 2018: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/29344042/effect-of-telephone-follow-up-by-nurses-on-self-care-in-children-with-diabetes
#18
Zahra Samimi, Sedigeh Talakoub, Zohreh Ghazavi
Background: Diabetes is a serious chronic disease during childhood. Because of the chronic nature of the disease, self-care is necessary. Education alone is not effective in providing care. Misunderstanding by the patients regarding diabetes during the training programs render telephone follow-up after training essential. Materials and Methods: This quasi-experimental study with two groups (experimental and control) was conducted in two phases in 2014. The study population consisted of 70 children of 10-18 years of age with type I diabetes (35 patients in the experimental group and 35 in the control group)...
January 2018: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29343992/validation-of-bp-devices-qardioarm%C3%A2-in-the-general-population-and-omron-m6-comfort%C3%A2-in-type-ii-diabetic-patients-according-to-the-european-society-of-hypertension-international-protocol-esh-ip
#19
Mirna N Chahine, Jirar Topouchian, Parounak Zelveian, Zoya Hakobyan, Arevik Melkonyan, Alaa Azaki, Reem Diab, Aya Harb, Roland Asmar
Background: Following the European Society of Hypertension International Protocol (ESH-IP) Revision 2010, QardioArm® and Omron M6 Comfort IT® oscillometric devices were evaluated in the general population and in patients with type II diabetes, respectively, for self-blood pressure (BP) measurement. Methods: Both devices, QardioArm® and Omron M6 Comfort®, measure BP at the brachial level. The ESH-IP Revision 2010 includes a total number of 33 subjects. For each measure, the difference between observer and device BP values was calculated...
2018: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/29342229/a-rapid-epistatic-mixed-model-association-analysis-by-linear-retransformations-of-genomic-estimated-values
#20
Chao Ning, Dan Wang, Huimin Kang, Raphael Mrode, Lei Zhou, Shizhong Xu, Jian-Feng Liu
Motivation: Epistasis provides a feasible way for probing potential genetic mechanism of complex traits. However, time-consuming computation challenges successful detection of interaction in practice, especially when linear mixed model (LMM) is used to control type I error in the presence of population structure and cryptic relatedness. Results: A rapid epistatic mixed-model association analysis (REMMA) method was developed to overcome computational limitation. This method first estimates individuals' epistatic effects by an extended genomic best linear unbiased prediction (EG-BLUP) model with additive and epistatic kinship matrix, then pairwise interaction effects are obtained by linear retransformations of individuals' epistatic effects...
January 12, 2018: Bioinformatics
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