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https://www.readbyqxmd.com/read/28427145/uncoupling-genotoxic-stress-responses-from-circadian-control-increases-susceptibility-to-mammary-carcinogenesis
#1
Mingzhu Fang, Pamela A Ohman Strickland, Hwan-Goo Kang, Helmut Zarbl
We previously demonstrated that chemopreventive methylselenocysteine (MSC) prevents N-Nitroso-N-methylurea (NMU)-induced mammary carcinogenesis in the susceptible Fischer 344 (F344) rats by enhancing NAD+-dependent SIRT1 activity, restoring circadian expression of Period 2 (Per2) and circadian controlled genes. Here, we show that compared to the genetically resistant Copenhagen (COP) rat strain, mammary glands of the F344 rats have a 4-hour phase delay in circadian expression of Per2. Consequently, F344 rats failed to increase SIRT1 activity and circadian expression of Per2 and DDRR genes after exposure to NMU...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423013/mapping-the-co-localization-of-the-circadian-proteins-per2-and-bmal1-with-enkephalin-and-substance-p-throughout-the-rodent-forebrain
#2
Ariana Frederick, Jory Goldsmith, Nuria de Zavalia, Shimon Amir
Despite rhythmic expression of clock genes being found throughout the central nervous system, very little is known about their function outside of the suprachiasmatic nucleus. Determining the pattern of clock gene expression across neuronal subpopulations is a key step in understanding their regulation and how they may influence the functions of various brain structures. Using immunofluorescence and confocal microscopy, we quantified the co-expression of the clock proteins BMAL1 and PER2 with two neuropeptides, Substance P (SubP) and Enkephalin (Enk), expressed in distinct neuronal populations throughout the forebrain...
2017: PloS One
https://www.readbyqxmd.com/read/28422445/transcriptional-profiling-of-shr-ncrl-prefrontal-cortex-reveals-hyperactivity-associated-genes-responsive-to-amphetamine-challenge
#3
Irene Joy I Dela Peña, Ike Dela Peña, June Bryan de la Peña, Hee Jin Kim, Aeree Sohn, Chan Young Shin, Doug Hyun Han, Bung-Nyun Kim, Jong Hoon Ryu, Jae Hoon Cheong
Several studies suggest a strong genetic component of attention-deficit/hyperactivity disorder (ADHD), a complex neurodevelopmental disorder characterized by inappropriate levels of hyperactivity, impulsivity, and inattention. Determining specific genetic risk variants for each symptom dimension of ADHD may aid in the identification of the biological risk factors of the disorder. In this study, we explored the potential genetic underpinnings of the hyperactive phenotype of ADHD. To this end, we examined differentially expressed genes (DEGs) in the prefrontal cortex (PFC) of SHR/NCrl, an animal model of ADHD, compared with its genetic control, the Wistar Kyoto (WKY/NCrl) rat and the Wistar rat, strain used to represent the "normal" heterogeneous population...
April 19, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28419375/transcriptional-profiling-of-cholinergic-neurons-from-basal-forebrain-identifies-changes-in-expression-of-genes-between-sleep-and-wake-mrna-profiling-in-basal-forebrain-with-sleep-sleep-deprivation
#4
Elena V Nikonova, Jason DA Gilliland, Keith Q Tanis, Alexei A Podtelezhnikov, Alison M Rigby, Raymond J Galante, Eva M Finney, David J Stone, John J Renger, Allan I Pack, Christopher J Winrow
Study objective: To assess differences in gene expression in cholinergic basal forebrain cells between sleeping and sleep deprived mice sacrificed at the same time of day. Methods: Tg(ChAT-eGFP)86Gsat mice expressing eGFP under control of the choline acetyltransferase (Chat) promoter were utilized to guide laser capture of cholinergic cells in basal forebrain. mRNA expression levels in these cells were profiled using microarrays. Gene expression in eGFP(+) neurons was compared (1) to that in eGFP(-) neurons and to adjacent white matter, (2) between 7:00 am (lights on) and 7:00 pm (lights off), (3) between sleep deprived and sleeping animals at 0, 3, 6, 9 hrs from lights on...
April 13, 2017: Sleep
https://www.readbyqxmd.com/read/28417351/detrimental-effect-of-maternal-and-post-weaning-high-fat-diet-on-the-reproductive-function-in-the-adult-female-offspring-rat-roles-of-insulin-like-growth-factor-2-and-the-ovarian-circadian-clock
#5
Yu-Ju Lin, Ching-Chou Tsai, Li-Tung Huang, Jiunn-Ming Sheen, Mao-Meng Tiao, Hong-Ren Yu, Chih-Cheng Chen, You-Lin Tain
PURPOSE: We evaluate the impact of maternal and post-weaning high-fat (HF) diet on ovarian follicular population, steroidogenesis, and gene expression with a focus on the circadian clock system and insulin-like growth factor 2 (Igf2) in adult offspring ovaries, and to elucidate whether a maternal and post-weaning diet confers similar risks. METHODS: Virgin Sprague-Dawley rats were fed with normal chow (C) diet or HF diet for 5 weeks before mating, during gestation, and lactation...
April 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28408140/differential-menopause-versus-aging-induced-changes-in-oxidative-stress-and-circadian-rhythm-gene-markers
#6
Oriol A Rangel-Zuñiga, Cristina Cruz-Teno, Carmen Haro, Gracia M Quintana-Navarro, Fernando Camara-Martos, Pablo Perez-Martinez, Antonio Garcia-Rios, Marta Garaulet, Manuel Tena-Sempere, Jose Lopez-Miranda, Francisco Perez-Jimenez, Antonio Camargo
Menopause is characterized by the depletion of estrogen that has been proposed to cause oxidative stress. Circadian rhythm is an internal biological clock that controls physiological processes. It was analyzed the gene expression in peripheral blood mononuclear cells and the lipids and glucose levels in plasma of a subgroup of 17 pre-menopausal women, 19 men age-matched as control group for the pre-menopausal women, 20 post-menopausal women and 20 men age-matched as control group for the post-menopausal women; all groups were matched by body mass index...
April 10, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28395871/a-circadian-genomic-signature-common-to-ketamine-and-sleep-deprivation-in-the-anterior-cingulate-cortex
#7
Ricardo Orozco-Solis, Emilie Montellier, Lorena Aguilar-Arnal, Shogo Sato, Marquis P Vawter, Blynn G Bunney, William E Bunney, Paolo Sassone-Corsi
BACKGROUND: Conventional antidepressants usually require several weeks to achieve a full clinical response in patients with major depressive disorder, an illness associated with dysregulated circadian rhythms and a high incidence of suicidality. Two rapid-acting antidepressant strategies, low-dose ketamine (KT) and sleep deprivation (SD) therapies, dramatically reduce depressive symptoms within 24 hours in a subset of major depressive disorder patients. However, it is unknown whether they exert their actions through shared regulatory mechanisms...
March 1, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28370493/melatonin-administration-to-wild-type-mice-and-non-treated-nlrp3-mutant-mice-share-similar-inhibition-of-the-inflammatory-response-during-sepsis
#8
Ibtissem Rahim, Bahia Djerdjouri, Ramy K Sayed, Marisol Fernández-Ortiz, Beatriz Fernández-Gil, Agustín Hidalgo-Gutiérrez, Luis C López, Germaine Escames, Russel J Reiter, Dario Acuna-Castroviejo
The NLRP3 inflammasome is involved in the innate immune response during inflammation. Moreover, melatonin blunts the NF-κB/NLRP3 connection during sepsis. Thus, we compared the roles of the NLRP3 inflammasome and/or melatonin treatment in the septic response of wild-type and NLRP3(-/-) mice. Mouse myocardial tissue was used for this purpose. The nuclear turnover of NF-κB was enhanced during sepsis, with an increase in TNFα, iNOS, and pro-IL-1β. The lack of inflammasome in NLRP3(-/-) mice significantly reduced that response and blunted IL-1β maturation due to the lack of caspase-1...
March 31, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28352282/poor-sleep-quality-is-associated-with-dawn-phenomenon-and-impaired-circadian-clock-gene-expression-in-subjects-with-type-2-diabetes-mellitus
#9
Yuxin Huang, Haidong Wang, Yuan Li, Xiaoming Tao, Jiao Sun
Aims. We investigated whether poor sleep quality is associated with both dawn phenomenon and impaired circadian clock gene expression in subjects with diabetes. Methods. 81 subjects with diabetes on continuous glucose monitoring were divided into two groups according to the Pittsburgh Sleep Quality Index. The magnitude of dawn phenomenon was quantified by its increment from nocturnal nadir to prebreakfast. Peripheral leucocytes were sampled from 81 subjects with diabetes and 28 normal controls at 09:00. Transcript levels of circadian clock genes (BMAL1, PER1, PER2, and PER3) were determined by real-time quantitative polymerase chain reaction...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28352249/high-fat-feeding-does-not-disrupt-daily-rhythms-in-female-mice-because-of-protection-by-ovarian-hormones
#10
Brian T Palmisano, John M Stafford, Julie S Pendergast
Obesity in women is increased by the loss of circulating estrogen after menopause. Shift work, which disrupts circadian rhythms, also increases the risk for obesity. It is not known whether ovarian hormones interact with the circadian system to protect females from obesity. During high-fat feeding, male C57BL/6J mice develop profound obesity and disruption of daily rhythms. Since C57BL/6J female mice did not develop diet-induced obesity (during 8 weeks of high-fat feeding), we first determined if daily rhythms in female mice were resistant to disruption from high-fat diet...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28350992/expression-of-circadian-core-clock-genes-in-fibroblasts-of-human-gingiva-and-periodontal-ligament-is-modulated-by-l-mimosine-and-hypoxia-in-monolayer-and-spheroid-cultures
#11
Klara Janjić, Christoph Kurzmann, Andreas Moritz, Hermann Agis
OBJECTIVE: The circadian clock is involved in a plethora of physiological processes including bone formation and tooth development. While expression of circadian core clock genes was observed in various tissues, their role in the periodontium is unclear. We hypothesized that periodontal cells express circadian core clock genes and that their levels are modulated by hypoxia mimetic agents and hypoxia. MATERIAL AND METHODS: Fibroblasts of human gingiva (GF) and periodontal ligament (PDLF) in monolayer and spheroid cultures were treated with the hypoxia mimetic agent L-Mimosine (L-MIM) or hypoxia...
March 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28326909/resynchronization-dynamics-reveal-that-the-ventral-entrains-the-dorsal-suprachiasmatic-nucleus
#12
Stephanie R Taylor, Thomas J Wang, Daniel Granados-Fuentes, Erik D Herzog
Although the suprachiasmatic nucleus (SCN) has long been considered the master circadian clock in mammals, the topology of the connections that synchronize daily rhythms among SCN cells is not well understood. We combined experimental and computational methods to infer the directed interactions that mediate circadian synchrony between regions of the SCN. We analyzed PERIOD2 (PER2) expression from SCN slices during and after treatment with tetrodotoxin, allowing us to map connections as cells resynchronized their daily cycling following blockade and restoration of cell-cell communication...
February 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28326728/-effect-of-clock-gene-per1-knockdown-on-clock-gene-networks-in-human-oral-squamous-cell-carcinoma
#13
Zhao Qin, Ao Yiran, Yang Kai, Su Xiaoli, Lü Xiaoqiang
OBJECTIVE: This study investigated the effect of clock gene PER1 on the expression levels of other clock genes in clock gene networks in oral squamous cell carcinoma cells. METHODS: We used RNA interference mediated by short hairpin RNAs (shRNAs) to effectively knock down PER1 in SCC15 human oral squamous cell carcinoma cells. Flow cytometry was used to detect the degree of proliferation and apoptosis of the cells after PER1 knockdown, and quantitative real-time PCR was used to detect the mRNA expression levels of the clock genes CLOCK, BMAL1, PER1, PER2, PER3, DEC1, DEC2, CRY1, CRY2, TIM, CKIE, RORA, NPAS2, and REV-ERBA...
February 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28324022/postnatal-ontogeny-of-the-circadian-expression-of-the-adrenal-clock-genes-and-corticosterone-rhythm-in-male-rats
#14
Silvia Liliana Ruiz Roa, Edson Zangiacomi Martinez, Clarissa Silva Martins, Sonir Rauber Antonini, Margaret de Castro, Ayrton Custódio Moreira
The postnatal synchronization of the circadian variation of the adrenal clock genes in mammals remains unknown. We evaluated the postnatal ontogeny of daily variation of clock genes (Clock/Bmal1/Per1/Per2/Per3/Cry1/Cry2/Rorα/Rev-Erbα) and steroidogenesis-related genes (Star and Mc2r) in rat adrenals and its relationship with the emergence of plasma corticosterone rhythm using Cosinor analysis. Plasma corticosterone circadian rhythm was detected from postnatal day (P) P1, with morning acrophase, between zeitgeber time (ZT) ZT0 and ZT2...
January 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28318412/effects-of-lithium-and-2-4-dichlorophenol-on-zebrafish-circadian-rhythm-disorder-and-molecular-effects
#15
Bo Xiao, Li-Qiang Cui, Cheng Ding, Han Wang
The aim of this study was to investigate lithium and 2,4-dichlorophenol (2,4-DCP)-induced circadian rhythm disorder and their genome-wide effects in zebrafish. Zebrafish larvae were exposed to 250 ppm LiCl (n = 40) or 20 ppm 2,4-DCP. RNA was subsequently extracted and determined quantitatively. The mRNA levels of circadian clock-related genes, including clock1a, bmal1b, per2, and per1b, were determined. Microarray datasets were generated and the differentially expressed genes (DEGs) were identified. The mRNA levels of some upregulated and downregulated DEGs were examined by quantitative real-time polymerase chain reaction (RT-PCR)...
March 20, 2017: Zebrafish
https://www.readbyqxmd.com/read/28317486/abnormal-clock-gene-expression-and-locomotor-activity-rhythms-in-two-month-old-female-appswe-ps1de9-mice
#16
Olaide Oyegbami, Hilary M Collins, Marie C Pardon, Fran Jp Ebling, David M Heery, Paula M Moran
In addition to cognitive decline, Alzheimer's disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as 'sundowning'. These symptoms are especially difficult for carers and there are no specific drug treatments. There is increasing evidence that these symptoms reflect an underlying pathology of circadian rhythm generation and transmission. We investigated whether a transgenic mouse model relevant to AD (APPswe/PS1dE9) exhibits circadian alterations in locomotor activity and expression of clock genes involved in the regulation of the circadian cycle...
March 17, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28296937/effects-of-circadian-clock-genes-and-health-related-behavior-on-metabolic-syndrome-in-a-taiwanese-population-evidence-from-association-and-interaction-analysis
#17
Eugene Lin, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Shih-Jen Tsai
Increased risk of developing metabolic syndrome (MetS) has been associated with the circadian clock genes. In this study, we assessed whether 29 circadian clock-related genes (including ADCYAP1, ARNTL, ARNTL2, BHLHE40, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, GSK3B, HCRTR2, KLF10, NFIL3, NPAS2, NR1D1, NR1D2, PER1, PER2, PER3, REV1, RORA, RORB, RORC, SENP3, SERPINE1, TIMELESS, TIPIN, VIP, and VIPR2) are associated with MetS and its individual components independently and/or through complex interactions in a Taiwanese population...
2017: PloS One
https://www.readbyqxmd.com/read/28286126/circadian-rhythms-of-hedonic-drinking-behavior-in-mice
#18
Claire Bainier, Maria Mateo, Marie-Paule Felder-Schmittbuhl, Jorge Mendoza
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the main circadian clock, synchronized by the light-dark cycle, which generates behavioral rhythms like feeding, drinking and activity. Notwithstanding, the main role of the SCN clock on the control of all circadian rhythms has been questioned due to the presence of clock activity in many brain areas, including those implicated in the regulation of feeding and reward. Moreover, whether circadian rhythms of particular motivated behaviors exist is unknown...
March 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/28283079/molecular-investigation-of-the-direct-anti-tumour-effects-of-nonsteroidal-anti-inflammatory-drugs-in-a-panel-of-canine-cancer-cell-lines
#19
R Yoshitake, K Saeki, M Watanabe, N Nakaoka, S M Ong, M Hanafusa, N Choisunirachon, N Fujita, R Nishimura, T Nakagawa
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been suggested as effective adjunctive anti-tumour agents in human and veterinary medicine. However, the molecular mechanisms associated with their anti-tumour effects and correlations with the expression of cyclooxygenase (COX) and related molecules in tumours remain controversial. The objective of this study was to compare the expression profiles of COX and related molecules with NSAID sensitivity and to explore the molecular mechanisms of anti-tumour effects...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28277108/temporal-effects-of-human-chorionic-gonadotropin-on-expression-of-the-circadian-genes-and-steroidogenesis-related-genes-in-human-luteinized-granulosa-cells
#20
Minghui Chen, Yanwen Xu, Benyu Miao, Hui Zhao, Jun Gao, Canquan Zhou
OBJECTIVE: It has been shown in animal models that circadian clock exists in corpora luteum which is essential for maintaining pregnancy. However, it is unknown whether circadian clock exists in corpora luteum and its relation with steroidogenesis in human ovary. STUDY DESIGN: Human luteinized granulosa cells from patients who underwent in vitro fertilization treatment were purified and cultured in vitro. Accumulation patterns of circadian gene and steroidogenesis-related gene mRNAs in human luteinized granulosa cells were observed during the 48 hours after treatment with human chorionic gonadotropin (hCG) by quantitative PCR...
March 5, 2017: Gynecological Endocrinology
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