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https://www.readbyqxmd.com/read/29154494/interplay-between-environmentally-modulated-feedback-loops-hypoxia-and-circadian-rhythms-two-sides-of-the-same-coin
#1
Reinhard Depping, Henrik Oster
Sensing of environmental parameters is critically important for cells of metazoan organisms. Members of the superfamily of bHLH-PAS transcription factors, involved in oxygen sensing and circadian rhythm generation, are important players in such molecular pathways. The interplay between both networks includes a so far unknown factor, connecting PER2 (circadian clocks) to hypoxia sensing (HIF-1 α) to result in a more adapted state of homeostasis at the right time.
November 2017: FEBS Journal
https://www.readbyqxmd.com/read/29144171/circadian-gene-methylation-in-rotating-shift-nurses-a-cross-sectional-study
#2
Edyta Reszka, Edyta Wieczorek, Monika Przybek, Ewa Jabłońska, Paweł Kałużny, Agnieszka Bukowska-Damska, Shanbeh Zienolddiny, Beata Pepłońska
Investigating the methylation status of the circadian genes may contribute to a better understanding of the shift work-related circadian disruption in individuals exposed to artificial light at night. In the present study, we determined the methylation status of the circadian genes associated with a shift work pattern among nurses and midwives participating in a cross-sectional study in Lodz, Poland. Quantitative methylation polymerase chain reaction assays were used to assess promoter CpG methylation in PER1, PER2, PER3, CRY1, CRY2, BMAL1, CLOCK, and NPAS2 in genomic DNA from whole blood of 347 women having a rotating-shift work schedule and 363 women working days only...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29138421/mperiod2-brdm1-and-other-single-period-mutant-mice-have-normal-food-anticipatory-activity
#3
Julie S Pendergast, Robert H Wendroth, Rio C Stenner, Charles D Keil, Shin Yamazaki
Animals anticipate the timing of food availability via the food-entrainable oscillator (FEO). The anatomical location and timekeeping mechanism of the FEO are unknown. Several studies showed the circadian gene, Period 2, is critical for FEO timekeeping. However, other studies concluded that canonical circadian genes are not essential for FEO timekeeping. In this study, we re-examined the effects of the Per2 (Brdm1) mutation on food entrainment using methods that have revealed robust food anticipatory activity in other mutant lines...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29115399/loss-of-the-clock-gene-per2-is-associated-with-cancer-development-and-altered-expression-of-important-tumor-related-genes-in-oral-cancer
#4
Honggang Xiong, Yixin Yang, Kai Yang, Dan Zhao, Hong Tang, Xiongwen Ran
Recent studies have demonstrated that abnormal expression of the clock gene PER2 is closely associated with the development of a variety of cancer types. However, the expression of PER2 in oral squamous cell carcinoma (OSCC), a common malignant tumor in humans, and its correlations with the clinicopathological parameters and survival time of OSCC patients and the altered expression of important tumor-related genes remain unclear. In the present study, we detected the mRNA and protein expression levels of PER2, PIK3CA, PTEN, P53, P14ARF and caspase‑8 in OSCC tissues and cancer-adjacent oral mucosa by reverse transcription-quantitative PCR (RT-qPCR), western blotting and immunohistochemistry...
October 31, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29113166/expression-of-circadian-clock-genes-in-human-colorectal-adenoma-and-carcinoma
#5
Tomoyuki Momma, Hirokazu Okayama, Masaru Saitou, Hidekazu Sugeno, Nobuhiro Yoshimoto, Yuji Takebayashi, Shinji Ohki, Seiichi Takenoshita
Circadian rhythms are fundamental biological systems in most organisms. Epidemiological and animal studies have demonstrated that disruption of circadian rhythms is linked to tumor progression and mammalian tumorigenesis. However, the clinical significance of in situ clock gene expression in precancerous and cancerous colorectal lesions remains unknown. The present study aimed to investigate mRNA transcript levels of circadian clock genes within human colorectal cancer and adenoma tissue sections. Using in situ hybridization, the expression of key clock genes, including period circadian protein homolog (Per) 1 and 2, cryptochrome 1 (Cry1), circadian locomoter output cycles protein kaput (Clock), brain and muscle ARNT-like protein 1 (Bmal1) and casein kinase 1ε (CK1ε) were retrospectively examined in 51 cases of colorectal carcinoma and 10 cases of adenoma...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29111822/repercussions-of-hypo-and-hyperthyroidism-on-the-heart-circadian-clock
#6
Rodrigo A Peliciari-Garcia, Paula Bargi-Souza, Martin E Young, Maria Tereza Nunes
Myocardial gene expression and metabolism fluctuate over the course of the day in association with changes in energy supply and demand. Time-of-day-dependent oscillations in myocardial processes have been linked to the intrinsic cardiomyocyte circadian clock. Triiodothyronine (T3) is an important modulator of heart metabolism and function. Recently, our group has reported time-of-day-dependent rhythms in cardiac T3 sensitivity, as well as, T3-mediated acute alterations on core clock components. Hypo and hyperthyroidism are the second most prevalent endocrine disease worldwide...
November 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29108063/rapid-communication-period2-gene-silencing-increases-the-synthesis-of-%C3%AE-s-casein-protein-in-bovine-mammary-epithelial-cells
#7
L Y Hu, M Z Wang, J L Ouyang, P F Li, J J Loor
(), a core clock gene, encodes a circadian rhythm protein which has been shown to control mammary metabolism in rodents. Whether regulates milk component synthesis such as α-casein protein in bovine mammary cells is unknown. Thus, we used gene silencing technology to determine if silencing could affect α-casein synthesis and cell growth in cultured primary bovine mammary epithelial cells (BMEC). The BMEC were established by enzymatic digestion of mammary tissue from mid-lactation cows. A transient-transfection technique was used to insert a small interfering RNA (siRNA) oligonucleotide specific for to inhibit transcription...
October 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/29106308/sleep-quality-and-methylation-status-of-core-circadian-rhythm-genes-among-nurses-and-midwives
#8
Agnieszka Bukowska-Damska, Edyta Reszka, Pawel Kaluzny, Edyta Wieczorek, Monika Przybek, Shanbeh Zienolddiny, Beata Peplonska
ABSTARCT Poor sleep quality or sleep restriction is associated with sleepiness and concentration problems. Moreover, chronic sleep restriction may affect metabolism, hormone secretion patterns and inflammatory responses. Limited recent reports suggest a potential link between sleep deprivation and epigenetic effects such as changes in DNA methylation profiles. The aim of the present study was to assess the potential association between poor sleep quality or sleep duration and the levels of 5-methylcytosine in the promoter regions of PER1, PER2, PER3, BMAL1, CLOCK, CRY1 CRY2 and NPAS2 genes, taking into account rotating night work and chronotype as potential confounders or modifiers...
November 6, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29105092/ultraviolet-a-eye-irradiation-ameliorates-atopic-dermatitis-via-p53-and-clock-gene-proteins-in-nc-nga-mice
#9
Keiichi Hiramoto, Yurika Yamate, Satoshi Yokoyama
Atopic dermatitis (AD) is a widespread chronic skin condition that severely affects quality of life and can lead to more serious complications. Although ultraviolet (UV)A eye irradiation can exert various effects on the skin, it is unknown whether UVA can affect AD. To investigate potential associations, we used an NC/Nga mouse model of AD to study the effects of UVA eye irradiation. The eyes of mice were irradiated with a UVA dose of 100 kJ/m(2) using a FL20SBLB-A lamp. Our histological data demonstrated that AD symptoms could be ameliorated by UVA eye irradiation...
November 4, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29054877/ontogeny-of-circadian-rhythms-and-synchrony-in-the-suprachiasmatic-nucleus
#10
Vania Carmona-Alcocer, John H Abel, Tao C Sun, Linda R Petzold, Francis J Doyle, Carrie L Simms, Erik D Herzog
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates daily rhythms including sleep-wake, hormone release and gene expression. The cells of the SCN must synchronize to each other to drive these circadian rhythms in the rest of the body. The ontogeny of circadian cycling and intercellular coupling in the SCN remains poorly understood. Recent in vitro studies have recorded circadian rhythms from the whole embryonic SCN. Here, we tracked the onset and precision of rhythms in PERIOD2 (PER2), a clock protein, within the SCN isolated from embryonic and postnatal mice of undetermined sex...
October 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29050555/natural-variation-in-human-clocks
#11
Malcolm von Schantz
Our own species has a diurnal activity pattern and an average circadian period of 24.2h. Exact determination of circadian period requires expensive and intrusive protocols, and investigators are therefore using chronotype questionnaires as a proxy quantitative measure. Both measures show a normal distribution suggestive of a polygenic trait. The genetic components of the 24-h feedback loop that generates circadian rhythms within our cells have been mapped in detail, identifying a number of candidate genes which have been investigated for genetic polymorphisms relating to the phenotypic variance...
2017: Advances in Genetics
https://www.readbyqxmd.com/read/29045837/the-circadian-clock-gene-bmal1-controls-thyroid-hormone-mediated-spectral-identity-and-cone-photoreceptor-function
#12
Onkar B Sawant, Amanda M Horton, Olivia F Zucaro, Ricky Chan, Vera L Bonilha, Ivy S Samuels, Sujata Rao
Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision. Here, we define the molecular function of circadian activity within cone photoreceptors and reveal a role for the clock genes Bmal1 and Per2 in regulating cone spectral identity. ChIP analysis revealed that BMAL1 binds to the promoter region of the thyroid hormone (TH)-activating enzyme type 2 iodothyronine deiodinase (Dio2) and thus regulates the expression of Dio2...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29021622/the-circadian-transcriptome-of-marine-fish-sparus-aurata-larvae-reveals-highly-synchronized-biological-processes-at-the-whole-organism-level
#13
M Yúfera, E Perera, J A Mata-Sotres, J Calduch-Giner, G Martínez-Rodríguez, J Pérez-Sánchez
The regulation of circadian gene expression remains largely unknown in farmed fish larvae. In this study, a high-density oligonucleotide microarray was used to examine the daily expression of 13,939 unique genes in whole gilthead sea bream (Sparus aurata) larvae with fast growth potentiality. Up to 2,229 genes were differentially expressed, and the first two components of Principal Component Analysis explained more than 81% of the total variance. Clustering analysis of differentially expressed genes identified 4 major clusters that were triggered sequentially, with a maximum expression at 0 h, 3 h, 9-15 h and 18-21 h zeitgeber time...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992598/global-transcriptomic-analysis-of-zebrafish-in-response-to-embryonic-exposure-to-three-antidepressants-amitriptyline-fluoxetine-and-mianserin
#14
Minghong Wu, Shuai Liu, Lei Hu, Haidong Qu, Chenyuan Pan, Penghui Lei, Yingjia Shen, Ming Yang
Antidepressants are among the most commonly detected pharmaceuticals in aqueous systems, and, as emerging organic pollutants, may exert negative effects on non-target aquatic organisms. Previously, it has been revealed that antidepressant exposure significantly inhibits the growth and development of fish during their early developmental stages. Thus, in the present study, we aimed to identify and compare the underlying mechanisms of action of different antidepressants at the transcriptional level using zebrafish (Danio rerio) embryos...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28981604/an-individual-12-h-shift-of-the-light-dark-cycle-alters-the-pancreatic-and-duodenal-circadian-rhythm-and-digestive-function
#15
Liang Xu, Tao Wu, Haifeng Li, Yinhua Ni, Zhengwei Fu
In mammals, behavioral and physiological rhythms are controlled by circadian clocks which are entrained by environmental light and food signals. However, how the environmental cues affect digestive tract's circadian clock remains poorly understood. Therefore, in order to elucidate the effect of light cue on the resetting of the peripheral clocks, we investigated the expressions of clock genes (Bmal1, Cry1, Rev-erbα, Per1, and Per2) and digestive function genes (Cck, Cck-1r, Sct, Sctr, and Ctrb1) in the pancreas and duodenum of rats after the light-dark (LD) cycle reversal for 7 days...
October 1, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28973913/period2-3-utr-and-microrna-24-regulate-circadian-rhythms-by-repressing-period2-protein-accumulation
#16
Seung-Hee Yoo, Shihoko Kojima, Kazuhiro Shimomura, Nobuya Koike, Ethan D Buhr, Tadashi Furukawa, Caroline H Ko, Gabrielle Gloston, Christopher Ayoub, Kazunari Nohara, Bryan A Reyes, Yoshiki Tsuchiya, Ook-Joon Yoo, Kazuhiro Yagita, Choogon Lee, Zheng Chen, Shin Yamazaki, Carla B Green, Joseph S Takahashi
We previously created two PER2::LUCIFERASE (PER2::LUC) circadian reporter knockin mice that differ only in the Per2 3'-UTR region: Per2::Luc, which retains the endogenous Per2 3'-UTR and Per2::LucSV, where the endogenous Per2 3'-UTR was replaced by an SV40 late poly(A) signal. To delineate the in vivo functions of Per2 3'-UTR, we analyzed circadian rhythms of Per2::LucSV mice. Interestingly, Per2::LucSV mice displayed more than threefold stronger amplitude in bioluminescence rhythms than Per2::Luc mice, and also exhibited lengthened free-running periods (∼24...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28971988/high-dietary-sodium-causes-dyssynchrony-of-the-renal-molecular-clock-in-rats
#17
Joshua S Speed, Kelly A Hyndman, Kaehler J Roth, Jonathan Brett Heimlich, Malgorzata Kasztan, Brandon M Fox, Jermaine G Johnston, Bryan K Becker, Chunhua Jin, Karen L Gamble, Martin E Young, Jennifer S Pollock, David M Pollock
Dyssynchrony of circadian rhythms are associated with various disorders, including cardiovascular and metabolic diseases. The cell autonomous molecular clock maintains circadian control, however, environmental factors that may cause circadian dyssynchrony either within or between organ systems are poorly understood. Our lab recently reported that the endothelin B (ETB) receptor functions to facilitate Na+ excretion in a time of day dependent manner. Therefore, the current study was designed to determine whether high salt (HS) intake leads to circadian dyssynchrony within the kidney, and whether the renal endothelin system contributes to control of the renal molecular clock...
September 27, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28970786/circadian-clock-protein-content-and-daily-rhythm-of-locomotor-activity-are-altered-after-chronic-exposure-to-lead-in-rat
#18
Mariam Sabbar, Ouria Dkhissi-Benyahya, Abdelhamid Benazzouz, Nouria Lakhdar-Ghazal
Lead exposure has been reported to produce many clinical features, including parkinsonism. However, its consequences on the circadian rhythms are still unknown. Here we aimed to examine the circadian rhythms of locomotor activity following lead intoxication and investigate the mechanisms by which lead may induce alterations of circadian rhythms in rats. Male Wistar rats were injected with lead or sodium acetate (10 mg/kg/day, i.p.) during 4 weeks. Both groups were tested in the "open field" to quantify the exploratory activity and in the rotarod to evaluate motor coordination...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28963769/a-circadian-clock-gene-per2-activates-hif-1-as-an-effector-molecule-for-recruitment-of-hif-1%C3%AE-to-promoter-regions-of-its-downstream-genes
#19
EDITORIAL
Minoru Kobayashi, Akiyo Morinibu, Sho Koyasu, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor functioning in cellular adaptive responses to hypoxia. Recent studies have suggested that HIF-1 activity is upregulated by one of the important circadian clock genes, period circadian clock 2 (PER2); however, its underlying mechanism remains unclear. Here, we show that PER2 functions as an effector protein for the recruitment of HIF-1α to its cognate enhancer sequence, the hypoxia-response element (HRE). We found that the forced expression of PER2 enhanced HIF-1 activity without influencing expression levels of the regulatory subunit of HIF-1, HIF-1α, at either mRNA or protein levels...
September 30, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28960346/creb-mediates-alcohol-induced-circadian-disruption-and-intestinal-permeability
#20
Booker T Davis, Robin M Voigt, Maliha Shaikh, Christopher B Forsyth, Ali Keshavarzian
BACKGROUND: Alcoholic Liver Disease (ALD) is commonly associated with intestinal permeability. An unanswered question is why only a subset of heavy alcohol drinkers develop endotoxemia. Recent studies suggest that circadian disruption is the susceptibility factor for alcohol-induced gut leakiness to endotoxins. The circadian protein PER2 is increased after exposure to alcohol and siRNA knockdown of PER2 in vitro blocks alcohol-induced intestinal barrier dysfunction. We have shown that blocking CYP2E1 (i...
September 27, 2017: Alcoholism, Clinical and Experimental Research
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