Adam H Freedman, Rena M Schweizer, Diego Ortega-Del Vecchyo, Eunjung Han, Brian W Davis, Ilan Gronau, Pedro M Silva, Marco Galaverni, Zhenxin Fan, Peter Marx, Belen Lorente-Galdos, Oscar Ramirez, Farhad Hormozdiari, Can Alkan, Carles Vilà, Kevin Squire, Eli Geffen, Josip Kusak, Adam R Boyko, Heidi G Parker, Clarence Lee, Vasisht Tadigotla, Adam Siepel, Carlos D Bustamante, Timothy T Harkins, Stanley F Nelson, Tomas Marques-Bonet, Elaine A Ostrander, Robert K Wayne, John Novembre
Controlling for background demographic effects is important for accurately identifying loci that have recently undergone positive selection. To date, the effects of demography have not yet been explicitly considered when identifying loci under selection during dog domestication. To investigate positive selection on the dog lineage early in the domestication, we examined patterns of polymorphism in six canid genomes that were previously used to infer a demographic model of dog domestication. Using an inferred demographic model, we computed false discovery rates (FDR) and identified 349 outlier regions consistent with positive selection at a low FDR...
March 2016: PLoS Genetics