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https://www.readbyqxmd.com/read/28803917/sca1-cells-from-the-heart-possess-a-molecular-circadian-clock-and-display-circadian-oscillations-in-cellular-functions
#1
Bastiaan C Du Pré, Evelyne J Demkes, Dries A M Feyen, Pieterjan Dierickx, Sandra Crnko, Bart J M Kok, Joost P G Sluijter, Pieter A Doevendans, Marc A Vos, Toon A B Van Veen, Linda W Van Laake
Stem cell antigen 1-positive (SCA1(+)) cells (SPCs) have been investigated in cell-based cardiac repair and pharmacological research, although improved cardiac function after injection has been variable and the mode of action remains unclear. Circadian (24-hr) rhythms are biorhythms regulated by molecular clocks that play an important role in (patho)physiology. Here, we describe (1) the presence of a molecular circadian clock in SPCs and (2) circadian rhythmicity in SPC function. We isolated SPCs from human fetal heart and found that these cells possess a molecular clock based on typical oscillations in core clock components BMAL1 and CRY1...
August 8, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28802827/the-novel-heme-dependent-inducible-protein-srrd-regulates-heme-biosynthesis-and-circadian-rhythms
#2
Yuka Adachi, Mana Umeda, Asako Kawazoe, Tetsuya Sato, Yasuyuki Ohkawa, Sakihito Kitajima, Shingo Izawa, Ikuko Sagami, Shigeru Taketani
Heme plays a role in the regulation of the expression of genes related to circadian rhythms and heme metabolism. In order to identify new heme-regulated proteins, an RNA sequence analysis using mouse NIH3T3 cells treated without or with 5-aminolevulinic acid (ALA) was performed. Among the changes observed in the levels of various mRNAs including heme oxygenase-1 (HO-1) and ALA synthase-1 (ALAS1), a mouse homologue of the plant circadian-regulating protein SRR1, SRR1 domain containing (SRRD) was induced by the ALA treatment...
August 9, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28797635/circadian-rhythmicity-a-functional-connection-between-differentiated-embryonic-chondrocyte-1-dec1-and-small-heterodimer-partner-shp
#3
Marek M Marczak, Bingfang Yan
Circadian rhythm misalignment has been increasingly recognized to pose health risk for a wide range of diseases, particularly metabolic disorders. The liver maintains metabolic homeostasis and expresses many circadian genes, such as differentiated embryo chondrocyte-1 (DEC1) and small heterodimer partner (SHP). DEC1 is established to repress transcription through E-box elements, and SHP belongs to the superfamily of nuclear receptors and has multiple E-box elements in its promoter. Importantly, DEC1 and SHP are inversely oscillated...
August 8, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28765524/bmal1-regulates-inflammatory-responses-in-macrophages-by-modulating-enhancer-rna-transcription
#4
Yumiko Oishi, Shinichiro Hayashi, Takayuki Isagawa, Motohiko Oshima, Atsushi Iwama, Shigeki Shimba, Hitoshi Okamura, Ichiro Manabe
Bmal1 (encoded by Arntl gene) is a core circadian clock gene that regulates various genes involved in circadian rhythm. Although Bmal1 is expressed rhythmically in macrophages, the role of Bmal1 in the regulation of their cellular function remains insufficiently understood. Here, we report that Bmal1 regulates time-dependent inflammatory responses following Toll-like receptor 4 (TLR4) activation by modulating enhancer activity. Global transcriptome analysis indicated that deletion of Arntl perturbed the time-dependent inflammatory responses elicited by TLR4 activation by Kdo2-lipid A (KLA)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751364/circadian-repressors-cry1-and-cry2-broadly-interact-with-nuclear-receptors-and-modulate-transcriptional-activity
#5
Anna Kriebs, Sabine D Jordan, Erin Soto, Emma Henriksson, Colby R Sandate, Megan E Vaughan, Alanna B Chan, Drew Duglan, Stephanie J Papp, Anne-Laure Huber, Megan E Afetian, Ruth T Yu, Xuan Zhao, Michael Downes, Ronald M Evans, Katja A Lamia
Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circadian locomotor output cycles kaput (CLOCK) and brain and muscle ARNT-like 1 (BMAL1), and transcriptional repressors cryptochrome (CRY) and period (PER)...
July 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28746872/aberrant-proteostasis-of-bmal1%C3%A2-underlies-circadian-abnormalities-in-a-paradigmatic-mtor-opathy
#6
Jonathan O Lipton, Lara M Boyle, Elizabeth D Yuan, Kevin J Hochstrasser, Fortunate F Chifamba, Ashwin Nathan, Peter T Tsai, Fred Davis, Mustafa Sahin
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder characterized by mutations in either the TSC1 or TSC2 genes, whose products form a critical inhibitor of the mechanistic target of rapamycin (mTOR). Loss of TSC1/2 gene function renders an mTOR-overactivated state. Clinically, TSC manifests with epilepsy, intellectual disability, autism, and sleep dysfunction. Here, we report that mouse models of TSC have abnormal circadian rhythms. We show that mTOR regulates the proteostasis of the core clock protein BMAL1, affecting its translation, degradation, and subcellular localization...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28736261/genetic-disruption-of-the-cardiomyocyte-circadian-clock-differentially-influences-insulin-mediated-processes-in-the-heart
#7
Graham R McGinnis, Yawen Tang, Rachel A Brewer, Manoja K Brahma, Haley L Stanley, Gobinath Shanmugam, Namakkal Soorappan Rajasekaran, Glenn C Rowe, Stuart J Frank, Adam R Wende, E Dale Abel, Heinrich Taegtmeyer, Silvio Litovsky, Victor Darley-Usmar, Jianhua Zhang, John C Chatham, Martin E Young
Cardiovascular physiology exhibits time-of-day-dependent oscillations, which are mediated by both extrinsic (e.g., environment/behavior) and intrinsic (e.g., circadian clock) factors. Disruption of circadian rhythms negatively affects multiple cardiometabolic parameters. Recent studies suggest that the cardiomyocyte circadian clock directly modulates responsiveness of the heart to metabolic stimuli (e.g., fatty acids) and stresses (e.g., ischemia/reperfusion). The aim of this study was to determine whether genetic disruption of the cardiomyocyte circadian clock impacts insulin-regulated pathways in the heart...
July 20, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28730830/preventive-effect-of-l-carnitine-on-the-disorder-of-lipid-metabolism-and-circadian-cclock-of-mice-subjected-to-chronic-jet-lag
#8
X Xie, A Guo, T Wu, Q Hu, L Huang, C Yao, B Zhao, W Zhang, B Chi, P Lu, Z Zhao, Z Fu
Circadian clock plays an essential role in orchestrating daily physiology, and its disruption can evoke metabolic diseases such as obesity. L-Carnitine can reduce blood lipid levels, and ameliorate fatty liver through regulating lipid metabolism. However, whether L-Carnitine administration may affect the disturbance of lipid metabolism and circadian rhythm of mice induced by prolonged circadian disruption is still unknown. Herein, we investigated the effects of L-Carnitine on conditions of circadian clock and lipid metabolism through a chronic jet-lag mice model which was developed by reversing12 h light/12 h dark cycle every 4 days for a continuous 12 weeks...
July 18, 2017: Physiological Research
https://www.readbyqxmd.com/read/28729066/the-effect-of-high-fat-diet-on-daily-rhythm-of-the-core-clock-genes-and-muscle-functional-genes-in-the-skeletal-muscle-of-chinese-soft-shelled-turtle-trionyx-sinensis
#9
Li Liu, Guomin Jiang, Zhitao Peng, Yulong Li, Jinlong Li, Li Zou, Zhigang He, Xiaoqing Wang, Wuying Chu
In the present study, we sought to investigate the influence of high fat diet on the core clock genes and the muscle functional genes daily expression in the skeletal muscle of Chinese soft-shelled turtle. The turtles were fed by two diets including a control fat diet (the CON treatment, 7.98% lipid) and a high fat diet (the HFD treatment, 13.86% lipid) for six weeks and administrated by the photophase regimen of 24h light/dark (12L:12D) cycle. After the feeding trial experiment, we measured the daily expression levels of 17 core clock genes (Clock, Bmal1/2, NPAS2, Tim, Cry1/2, Per1/2, DBP, AANAT, NIFL3, BHLHE40, NR1D2, RORA, RORB, RORC) and 12 muscle functional genes (FBXO32, MBNL1, MSTN, Myf5, Myf6, MyoD, MyoG, MyoM1, PPARa, PDK4, Trim63, UCP3) in the skeletal muscle of the two treatments...
July 17, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28726633/bmal1-function-in-skeletal-muscle-regulates-sleep
#10
J Christopher Ehlen, Allison J Brager, Julie Baggs, Lennisha Pinckney, Cloe L Gray, Jason P DeBruyne, Karyn A Esser, Joseph S Takahashi, Ketema N Paul
Sleep loss can severely impair the ability to perform, yet the ability to recover from sleep loss is not well understood. Sleep regulatory processes are assumed to lie exclusively within the brain mainly due to the strong behavioral manifestations of sleep. Whole-body knockout of the circadian clock gene Bmal1 in mice affects several aspects of sleep, however, the cells/tissues responsible are unknown. We found that restoring Bmal1 expression in the brains of Bmal1-knockout mice did not rescue Bmal1-dependent sleep phenotypes...
July 20, 2017: ELife
https://www.readbyqxmd.com/read/28721450/smad3-and-bmal1-regulate-p21-and-s100a4-expression-in-myocardial-stromal-fibroblasts-via-tnf-%C3%AE
#11
Fuyuki Sato, Akira Kohsaka, Kana Takahashi, Saki Otao, Yusuke Kitada, Yoshiyuki Iwasaki, Yasuteru Muragaki
Bmal1, a clock gene, is associated with depression, hypertrophy, metabolic syndrome and diabetes. Smad3, which is involved in the TGF-β signaling pathway, plays an important role in the regulation of tumor progression, fibrosis, obesity and diabetes. Our previous report showed that Smad3 has circadian expression in mouse livers. In the current study, we focused on the heart, especially on the myocardial stromal fibroblasts because the roles of Bmal1 and Smad3 in this tissue are poorly understood. Bmal1 and Smad3 have circadian expression in mouse hearts, and their circadian expression patterns were similar...
July 18, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28720252/the-cryptochrome-photolyase-protein-family-in-diatoms
#12
Sarah König, Matthias Juhas, Stefanie Jäger, Tilman Kottke, Claudia Büchel
The cryptochrome - photolyase family (CPF) consists of homologous flavoproteins having completely different functions involving DNA repair, circadian rhythm and/or photoreception. From the original photolyases, working either as (6-4) or cyclobutane pyrimidine dimer photolyases, the animal- and plant-type cryptochromes, respectively, evolved and also the more intermediate DASH cryptochromes. Whereas animal cryptochromes work mostly in clock-related functions, plant cryptochromes are also directly involved in developmental processes such as hypocotyl elongation or flower induction...
July 8, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28715394/a-filtration-based-method-of-preparing-high-quality-nuclei-from-cross-linked-skeletal-muscle-for-chromatin-immunoprecipitation
#13
Kazunari Nohara, Zheng Chen, Seung-Hee Yoo
Chromatin immunoprecipitation (ChIP) is a powerful method to determine protein binding to chromatin DNA. Fiber-rich skeletal muscle, however, has been a challenge for ChIP due to technical difficulty in isolation of high-quality nuclei with minimal contamination of myofibrils. Previous protocols have attempted to purify nuclei before cross-linking, which incurs the risk of altered DNA-protein interaction during the prolonged nuclei preparation process. In the current protocol, we first cross-linked the skeletal muscle tissue collected from mice, and the tissues were minced and sonicated...
July 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28708501/bmal1-interference-impairs-hormone-synthesis-and-promotes-apoptosis-in-porcine-granulosa-cells
#14
Wusu Wang, Lin Yin, Long Bai, Guangjun Ma, Cunzhen Zhao, Aoqi Xiang, Weijun Pang, Gongshe Yang, Guiyan Chu
In mammals, granulosa cell proliferation, differentiation, luteinization, apoptosis, and hormone synthesis are tightly related to oocyte maturation, follicular development and ovarian function. In current study, we investigated the role of the key circadian clock gene, brain and muscle arnt-like protein-1 (Bmal1), on porcine granulosa cell hormone secretion and apoptosis. The transcription levels of circadian clock genes, including Bmal1 and period circadian clock 2 (Per2), were detected by RT-qPCR. We found that the circadian clock genes exhibited rhythmic change and were further enhanced by dexamethasone synchronization in granulosa cells...
May 23, 2017: Theriogenology
https://www.readbyqxmd.com/read/28699894/cancer-testis-antigen-piwil2-suppresses-circadian-rhythms-by-regulating-the-stability-and-activity-of-bmal1-and-clock
#15
Yilu Lu, Xulei Zheng, Wei Hu, Shasha Bian, Zhiwei Zhang, Dachang Tao, Yunqiang Liu, Yongxin Ma
Circadian rhythms are regulated by transcriptional and post-translational feedback loops generated by appropriate functions of clock proteins. Rhythmic degradation of the circadian clock proteins is critical for maintenance of the circadian oscillations. Notably, circadian clock does not work during spermatogenesis and can be disrupted in tumors. However, the underlying mechanism that suppresses circadian rhythms in germ cells and cancer cells remains largely unknown. Here we report that the cancer/testis antigen PIWIL2 can repress circadian rhythms both in the testis and cancer cells...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28687372/effects-of-a-free-choice-high-fat-high-sugar-diet-on-brain-per2-and-bmal1-protein-expression-in-mice
#16
Aurea Blancas-Velazquez, Susanne E la Fleur, Jorge Mendoza
The suprachiasmatic nucleus (SCN) times the daily rhythms of behavioral processes including feeding. Beyond the SCN, the hypothalamic arcuate nucleus (ARC), involved in feeding regulation and metabolism, and the epithalamic lateral habenula (LHb), implicated in reward processing, show circadian rhythmic activity. These brain oscillators are functionally coupled to coordinate the daily rhythm of food intake. In rats, a free choice high-fat high-sugar (fcHFHS) diet leads to a rapid increase of calorie intake and body weight gain...
October 1, 2017: Appetite
https://www.readbyqxmd.com/read/28683290/cry1-2-selectively-repress-ppar%C3%AE-and-limit-exercise-capacity
#17
Sabine D Jordan, Anna Kriebs, Megan Vaughan, Drew Duglan, Weiwei Fan, Emma Henriksson, Anne-Laure Huber, Stephanie J Papp, Madelena Nguyen, Megan Afetian, Michael Downes, Ruth T Yu, Anastasia Kralli, Ronald M Evans, Katja A Lamia
Cellular metabolite balance and mitochondrial function are under circadian control, but the pathways connecting the molecular clock to these functions are unclear. Peroxisome proliferator-activated receptor delta (PPARδ) enables preferential utilization of lipids as fuel during exercise and is a major driver of exercise endurance. We show here that the circadian repressors CRY1 and CRY2 function as co-repressors for PPARδ. Cry1(-/-);Cry2(-/-) myotubes and muscles exhibit elevated expression of PPARδ target genes, particularly in the context of exercise...
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28674733/micrornas-modulate-core-clock-gene-expression-in-pancreatic-islets-during-early-postnatal-life-in-rats
#18
Cécile Jacovetti, Adriana Rodriguez-Trejo, Claudiane Guay, Jonathan Sobel, Sonia Gattesco, Volodymyr Petrenko, Camille Saini, Charna Dibner, Romano Regazzi
AIMS/HYPOTHESIS: Evidence continues to emerge detailing a fine-tuning of the regulation of metabolic processes and energy homeostasis by cell-autonomous circadian clocks. Pancreatic beta cell functional maturation occurs after birth and implies transcriptional changes triggered by a shift in the nutritional supply that occurs at weaning, enabling the adaptation of insulin secretion. So far, the developmental timing and exact mechanisms involved in the initiation of the circadian clock in the growing pancreatic islets have never been addressed...
July 4, 2017: Diabetologia
https://www.readbyqxmd.com/read/28669630/crystal-structure-of-the-clock-transactivation-domain-exon19-in-complex-with-a-repressor
#19
Zhiqiang Hou, Lijing Su, Jimin Pei, Nick V Grishin, Hong Zhang
In the canonical clock model, CLOCK:BMAL1-mediated transcriptional activation is feedback regulated by its repressors CRY and PER and, in association with other coregulators, ultimately generates oscillatory gene expression patterns. How CLOCK:BMAL1 interacts with coregulator(s) is not well understood. Here we report the crystal structures of the mouse CLOCK transactivating domain Exon19 in complex with CIPC, a potent circadian repressor that functions independently of CRY and PER. The Exon19:CIPC complex adopts a three-helical coiled-coil bundle conformation containing two Exon19 helices and one CIPC...
August 1, 2017: Structure
https://www.readbyqxmd.com/read/28668516/effect-of-monochromatic-light-on-circadian-rhythmic-expression-of-clock-genes-in-the-hypothalamus-of-chick
#20
Nan Jiang, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
To clarify the effect of monochromatic light on circadian clock gene expression in chick hypothalamus, a total 240 newly hatched chickens were reared under blue light (BL), green light (GL), red light (RL) and white light (WL), respectively. On the post-hatched day 14, 24-h profiles of seven core clock genes (cClock, cBmal1, cBmal2, cCry1, cCry2, cPer2 and cPer3) were measured at six time points (CT 0, CT 4, CT 8, CT 12, CT 16, CT 20, circadian time). We found all these clock genes expressed with a significant rhythmicity in different light wavelength groups...
June 23, 2017: Journal of Photochemistry and Photobiology. B, Biology
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