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https://www.readbyqxmd.com/read/28739753/application-of-ultrasound-guided-core-needle-biopsy-in-the-diagnosis-of-t3-or-t4-stage-laryngeal-and-hypopharyngeal-cancer
#1
Yunqiang Wang, Dajian Li, Ruihua Liu, Chuanliang Jia, Aihua Jiang, Yayun Lv, Shufen Xu, Hua Zhang, Xiaoli Cao, Xicheng Song
AIM: To study the value of ultrasound-guided core needle biopsy (CNB) in the diagnosis of T3 or T4 stage laryngeal and hypopharyngeal cancer, which is difficult by routine methods. PATIENTS AND METHODS: Nineteen cases of T3 or T4 stage laryngeal or hypopharyngeal carcinoma with abnormal pharyngeal sensitivity, severe dyspnea, submucous cancer recurrence, cardiovascular and pulmonary dysfunction were reviewed retrospectively from October 2012 to October 2014 in the Yuhuangding Hospital of Qingdao University...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739733/analysis-of-association-between-mgmt-and-p53-gene-single-nucleotide-polymorphisms-and-laryngeal-cancer
#2
Yayun Lv, Chuanliang Jia, Aihua Jiang, Hua Zhang, Yunqiang Wang, Feifei Liu, Linlin Yang, Yan Sun, Runli Lv, Xicheng Song
AIM: To investigate the p53 and O(6)-methylguanine DNA methyltransferase (MGMT)5' upstream sequence gene promoter regions for single nucleotide polymorphisms and explore the p53 gene 5' upstream sequence consisting of two haplotypes to provide a genetic marker for the incidence of laryngeal squamous cell carcinoma. MATERIALS AND METHODS: We included 96 cases of laryngeal squamous cell carcinoma and 102 controls. We used SNaPshot micro-sequencing analysis of the MGMT promoter region for four single nucleotide polymorphisms and p53 gene 5' upstream sequence loci (rs1625649, rs2287499, rs2287498, rs228749) genotypes...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28730799/a-historical-overview-of-laryngeal-carcinoma-and-the-first-total-laryngectomies
#3
Marianna Karamanou, Kostas Markatos, Maria Lymperi, Emmanouil Agapitos, George Androutsos
Laryngeal cancer was a well known entity since antiquity and its treatment evolved through several phases. The lack of knowledge in anatomy and pathology as well as the absence of anesthesia and proper instrumentation made the treatment almost impossible. Ancient physicians were performing laryngotomy or tracheotomy in an attempt to prevent the suffocation symptoms produced by tumoral masses. In 19th century the invention of laryngoscope and the advent of pathology and anesthesiology encouraged surgeons to operate on man...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28730788/topoisomerase-i-deregulation-in-laryngeal-squamous-cell-carcinomas-based-on-tissue-microarray-analysis
#4
Theodoros A Papadas, Evangelos Tsiambas, Nicholas S Mastronikolis, Andreas Karameris, Stylianos N Mastronikolis, Athanasios T Papadas, Panagiotis P Fotiades, Vasileios Ragos
PURPOSE: Topoisomerases (types: I/IIa-b/IIIa-b) represent a super-family of nucleic enzymes involved in the DNA replication, transcription, recombination, and also chromosome topological formation. Topoisomerase's I (Topo I- gene location: 20q12) aberrant expression is a frequent genetic event in a variety of solid malignancies. Topo I inhibition promotes cell death due to DNA damage and for this reason it is a target for specific targeted chemotherapy (camptothecin, topotecan, irinotecan)...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28728249/-application-of-narrow-band-imaging-endoscopy-in-identifying-of-extent-disease-after-chemotherapy-for-laryngeal-carcinoma
#5
J Hou, X Y Ren, K Zhu, X Y Du, N Li, M J Yang
No abstract text is available yet for this article.
July 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28725538/a-rare-case-of-solitary-kidney-metastasis-following-primary-laryngeal-squamous-cell-carcinoma
#6
Sharon Del Vecchio, Robert Ellis, Kylie Gallagher, Keng Lim Ng, Li Ma, Geoffrey Strutton, Simon Wood
Laryngeal cancer is the 14th most common malignancy worldwide, and its common subtype squamous cell carcinoma (SCC) is highly associated with tobacco use and long-term alcohol consumption. The incidence of distant metastasis from a primary laryngeal cancer has been reported to be very low, between 6.5% and 8.5%, according to published tumour registry data. Distant metastases of laryngeal SCC most commonly involve the lung, liver, bone and mediastinum, seldom involving the kidney. Renal metastasis has been well established in many other cancers such as lymphoma, lung, breast and gastric carcinoma...
2017: Journal of Kidney Cancer and VHL
https://www.readbyqxmd.com/read/28725433/macrophage-type-2-differentiation-in-a-patient-with-laryngeal-squamous-cell-carcinoma-and-metastatic-prostate-adenocarcinoma-to-the-cervical-lymph-nodes
#7
Michael C Topf, Madalina Tuluc, Larry A Harshyne, Adam Luginbuhl
BACKGROUND: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. The tumor microenvironment contains a milieu of secreted factors and vesicles, which in certain circumstances can gain access to lymphatic vessels that drain to local lymph nodes...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28724656/dietary-flavonoid-intake-reduces-the-risk-of-head-and-neck-but-not-esophageal-or-gastric-cancer-in-us-men-and-women
#8
Lucy Sun, Amy F Subar, Claire Bosire, Sanford M Dawsey, Lisa L Kahle, Thea P Zimmerman, Christian C Abnet, Ruth Heller, Barry I Graubard, Michael B Cook, Jessica L Petrick
Background: Flavonoids are bioactive polyphenolic compounds found in fruits, vegetables, and beverages of plant origin. Previous studies have shown that flavonoid intake reduces the risk of certain cancers; however, few studies to date have examined associations of flavonoids with upper gastrointestinal cancers or used prospective cohorts.Objective: Our study examined the association between intake of flavonoids (anthocyanidins, flavan-3-ols, flavanones, flavones, flavonols, and isoflavones) and risk of head and neck, esophageal, and gastric cancers...
July 19, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#9
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716144/macrophage-type-2-differentiation-in-a-patient-with-laryngeal-squamous-cell-carcinoma-and-metastatic-prostate-adenocarcinoma-to-the-cervical-lymph-nodes
#10
Michael C Topf, Madalina Tuluc, Larry A Harshyne, Adam Luginbuhl
BACKGROUND: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. The tumor microenvironment contains a milieu of secreted factors and vesicles, which in certain circumstances can gain access to lymphatic vessels that drain to local lymph nodes...
July 18, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28713931/downregulation-of-mirna-26b-inhibits-cancer-proliferation-of-laryngeal-carcinoma-through-autophagy-by-targeting-ulk2-and-inactivation-of-the-pten-akt-pathway
#11
Shujing Wang, Dandan Guo, Congying Li
Laryngeal carcinoma is one of the most common tumors of the head and neck cancers, the pathogenesis of which remains yet unclear. It has been discovered through research that microRNAs (miRNAs) play an important role during the genesis of laryngeal carcinoma. In the present study we investigated the effect of miRNA-26b on the proliferation of laryngeal carcinoma and elucidated the potential underlying mechanisms in order to provide new targets for laryngeal carcinoma. Firstly, we found that miRNA-26b expression was significantly increased in patients with laryngeal carcinoma, compared with normal volunteers...
July 11, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28712408/-dectection-of-g3bp-and-cd44v6-in-the-tissues-of-laryngeal-squamous-cell-carcinoma-and-their-clinical-significance
#12
Dahu Luo, Weihua Lou
Objective To study the expressions of RNA-binding Ras-GAP SH3 binding protein (G3BP) and tumor stem cell marker CD44v6 in laryngeal squamous cell carcinoma and their correlations with angiogenesis. Methods We collected the cancer tissues and corresponding paracancerous tissues from 56 patients with laryngeal squamous cell carcinoma. The expressions of G3BP and CD44v6 proteins were detected by Western blotting in cancer tissues and corresponding paracancerous tissues; the expressions of G3BP, CD44v6 and vascular endothelial growth factor A (VEGF-A) were tested by immunohistochemistry...
July 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28710449/combined-deletion-and-dna-methylation-result-in-silencing-of-fam107a-gene-in-laryngeal-tumors
#13
Katarzyna Kiwerska, Marcin Szaumkessel, Julia Paczkowska, Magdalena Bodnar, Ewa Byzia, Ewelina Kowal, Magdalena Kostrzewska-Poczekaj, Joanna Janiszewska, Kinga Bednarek, Małgorzata Jarmuż-Szymczak, Ewelina Kalinowicz, Małgorzata Wierzbicka, Reidar Grenman, Krzysztof Szyfter, Andrzej Marszałek, Maciej Giefing
Larynx squamous cell carcinoma (LSCC) is characterized by complex genotypes, with numerous abnormalities in various genes. Despite the progress in diagnosis and treatment of this disease, 5-year survival rates remain unsatisfactory. Therefore, the extended studies are conducted, with the aim to find genes, potentially implicated in this cancer. In this study, we focus on the FAM107A (3p14.3) gene, since we found its significantly reduced expression in LSCC by microarray profiling (Affymetrix U133 Plus 2.0 array)...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710395/alterations-of-microbiota-structure-in-the-larynx-relevant-to-laryngeal-carcinoma
#14
Hongli Gong, Yi Shi, Xiyan Xiao, Pengyu Cao, Chunping Wu, Lei Tao, Dongsheng Hou, Yuezhu Wang, Liang Zhou
The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question by comparing the laryngeal microbiota structure in laryngeal cancer patients with that in control subjects with vocal cord polyps through high-throughput pyrosequencing. Overall, the genera Streptococcus, Fusobacterium, and Prevotella were prevalent bacterial populations in the laryngeal niche...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708883/impact-of-stage-management-and-recurrence-on-survival-rates-in-laryngeal-cancer
#15
Jesper Brandstorp-Boesen, Ragnhild Sørum Falk, Morten Boysen, Kjell Brøndbo
A retrospective, longitudinal study of 1,616 patients with primary laryngeal squamous cell carcinoma (LSCC) at a single center in Norway during 1983-2010 was undertaken to investigate overall survival, disease specific survival, disease-free survival, prognostic factors for overall survival, and impact of recurrence among all-stage laryngeal cancer patients over 15 years' follow-up. The prognostic impact of gender, age, smoking/alcohol, subsite, tumour, node and metastasis staging, period and modality of treatment were evaluated using Kaplan-Meier and Cox proportional hazard analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28708206/iqgap1-silencing-suppresses-the-malignant-characteristics-of-laryngeal-squamous-cell-carcinoma-cells
#16
Xiaoxia Wang, Chun He, Chaohui Li, Benhong Ren, Qing Deng, Wei Gao, Binquan Wang
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) has a poor prognosis due to recurrence and metastasis. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold protein, plays an important role in tumorigenesis and malignant development. In this study, we aimed to explore the role of IQGAP1 in LSCC. METHODS: Expression of IQGAP1 in human LSCC specimens was assessed by immunohistochemistry. We also evaluated the roles of IQGAP1 in cell proliferation, migration and invasion and epithelial-to-mesenchymal transition (EMT) in Hep-2 cells...
July 8, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28693206/role-of-t-helper-17-cytokines-in-the-tumour-immune-inflammation-response-of-patients-with-laryngeal-squamous-cell-carcinoma
#17
Wei-Jing Tang, Lei Tao, Li-Ming Lu, Di Tang, Xiao-Lin Shi
Altered cytokine production can lead to immune dysfunction in patients with cancer. The present study investigated the expression of T helper (Th)17 cytokines in patients with laryngeal squamous cell carcinoma (LSCC) and their clinical significance in providing new therapeutic insights. The prevalence of Th17 cells and their receptors in patients with LSCC was studied using immunohistochemical analysis via tissue microarray technology. Flow cytometry was used to investigate the percentage of Th17 and Th1 cells in peripheral blood mononuclear cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693195/microrna-125b-targeted-stat3-to-inhibit-laryngeal-squamous-cell-carcinoma-cell-growth-and-motility
#18
Juan Feng, Yuqin Fan, Qukuerhan Ayiheng, Hua Zhang, Jun Yong, Bin Hu
A majority of studies have indicated that microRNA-125b (miR-125b) is aberrantly expressed in various types of cancer. However, there are no studies on the expression and function of miR-125b in human laryngeal squamous cell carcinoma (LSCC). In the present study, miR-125b expression in LSCC sample tissues, corresponding adjacent non-neoplastic tissues, LSCC cell lines and a normal human keratinocyte cell line was measured using the reverse transcription-quantitative polymerase chain reaction. Following transfection with miR-125b mimics, the Cell Counting Kit-8, cell migration, cell invasion, western blotting and dual-luciferase reporter assays were performed on LSCC cell lines...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28688691/impact-of-combined-modality-treatment-with-radiotherapy-and-s-1-on-t2n0-laryngeal-cancer-possible-improvement-in-survival-through-the-prevention-of-second-primary-cancer-and-distant-metastasis
#19
Yosuke Kitani, Akira Kubota, Madoka Furukawa, Yukiko Hori, Yuko Nakayama, Tetsuo Nonaka, Nobutaka Mizoguchi, Yuka Kitani, Hiromitsu Hatakeyama, Nobuhiko Oridate
BACKGROUND: In patients with head and neck cancer, the management of second primary cancer (SPC) is particularly important for improving survival because of its high incidence and associated mortality. We evaluated the impact of combination chemotherapy on survival and SPC. METHOD: We retrospectively analyzed data from 49 patients treated with definitive radiation therapy (RT) for T2N0M0 laryngeal squamous cell carcinoma between 2003 and 2011. Among them, 22 patients received combined modality treatment with radiotherapy and S-1 (RT+CT group)...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28688688/survival-after-refusal-of-surgical-treatment-for-locally-advanced-laryngeal-cancer
#20
Sean T Massa, Nosayaba Osazuwa-Peters, Joel Franco, Gregory W Ward, Ronald J Walker
OBJECTIVE: Survival of advanced laryngeal cancer is declining while the popularity of organ preservation protocols grows. This study assesses the survival impact of refusing surgical treatment for locally advanced, resectable laryngeal cancer. METHODS: Adult patients with T3 and T4a non-metastatic laryngeal squamous cell carcinoma were identified from the Surveillance, Epidemiology and End Results 18 database from 2004 to 2013. Patients were stratified based on a recommendation for extirpative surgery and the refusal of surgery...
August 2017: Oral Oncology
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