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https://www.readbyqxmd.com/read/27926786/nut-midline-carcinoma-of-the-larynx-an-international-series-and-review-of-the-literature
#1
Henrik Hellquist, Christopher A French, Justin A Bishop, Andrés Coca-Pelaz, Evan J Propst, António Paiva Correia, Bo-Yee Ngan, Ronald Grant, Nicole A Cipriani, David Vokes, Rui Henrique, Fernando Pardal, Jose Ramon Vizcaino, Alessandra Rinaldo, Alfio Ferlito
AIMS: NUT midline carcinoma (NMC) is a rare undifferentiated and aggressive carcinoma that characteristically locates to the midline of the head and neck, and mediastinum. NMC is characterised by chromosomal rearrangements of the gene encoding nuclear protein in testis, NUT, at 15q14. The BRD4 gene on 19q13 is the most common translocation partner forming a fusion oncogene, BRD4-NUT. By the end of 2014, the International NUT Midline Carcinoma Registry had 48 patients treated for NMC. Laryngeal NMC are exceedingly rare and we report a case series of seven cases...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27924796/detection-and-phylogenetic-analysis-of-torque-teno-virus-in-salivary-and-tumor-biopsy-samples-from-head-and-neck-carcinoma-patients
#2
Andrea Hettmann, Anett Demcsák, Ádám Bach, Gábor Decsi, Ágnes Dencs, Dóra Pálinkó, László Rovó, Katalin Nagy, Janos Minarovits, Mária Takács
OBJECTIVES: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. METHODS: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used...
December 8, 2016: Intervirology
https://www.readbyqxmd.com/read/27920556/the-prognostic-value-of-systemic-and-local-inflammation-in-patients-with-laryngeal-squamous-cell-carcinoma
#3
Jie Wang, Shengzi Wang, Xinmao Song, Wenjiao Zeng, Shuyi Wang, Fu Chen, Hao Ding
BACKGROUND: Cancer-related systemic inflammation has been demonstrated to be associated with poor outcome in multiple types of cancers. Meanwhile, the local inflammation, which is characterized by dense intratumoral immune infiltrate, is a favorable predictor of survival outcome. PURPOSE: To evaluate the role of systemic and local inflammation in predicting outcome in patients with laryngeal squamous cell carcinoma. PATIENTS AND METHODS: In this retrospective study, 120 patients who had undergone postoperative radiotherapy were enrolled...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27919993/laryngo-esophageal-dysfunction-free-survival-in-a-preservation-protocol-for-t3-laryngeal-squamous-cell-carcinoma
#4
Philippe Gorphe, Margarida Matias, Caroline Even, Charles Ferte, François Bidault, Gabriel Garcia, Stéphane Temam, France Nguyen, Pierre Blanchard, Yungan Tao, François Janot
BACKGROUND: We reviewed the outcomes of patients with T3 laryngeal neoplasms with a fixed hemilarynx, a large gross tumor volume or a subglottic extension (SGE), treated with a laryngeal-preservation protocol with induction chemotherapy. PATIENTS AND METHODS: The study end-points were laryngo-esophageal dysfunction-free survival (LEDFS), laryngectomy-free survival (LFS), overall survival (OS), and disease-free survival (DFS). RESULTS: A total of 104 patients were included...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27914909/benefits-pitfalls-and-risks-of-phytotherapy-in-clinical-practice-in-otorhinolaryngology
#5
O Laccourreye, A Werner, L Laccourreye, P Bonfils
OBJECTIVES: To elucidate the benefits, pitfalls and risks of phytotherapy in the clinical practice of otorhinolaryngology. MATERIAL AND METHODS: The PubMed and Cochrane databases were searched using the following keywords: phytotherapy, phytomedicine, herbs, otology, rhinology, laryngology, otitis, rhinitis, laryngitis and otorhinolaryngology. Seventy-two articles (18 prospective randomized studies, 4 Cochrane analyses, 4 meta-analysis and 15 reviews of the literature) devoted to clinical studies were analyzed...
November 30, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27910227/preoperative-computed-tomography-diagnosis-of-non-recurrent-laryngeal-nerve-in-patients-with-esophageal-carcinoma
#6
Zhong-Xi Niu, Hang Zhang, Long-Qi Chen, Hui Shi, Jun Peng, Li-Wei Su, Wei Li, Bo Xiao, Shu He, Hong-Xu Yue
BACKGROUND: The non-recurrent laryngeal nerve (NRLN) is a rare but potentially serious anomaly that is commonly associated with the aberrant right subclavian artery (ARSA). It is easy to damage during surgical resection of esophageal cancer, leading to severe complications. METHODS: Preoperative enhanced thoracic computed tomography (CT) scans of 2697 patients with esophageal carcinoma treated in our hospital between January 2010 and December 2013 were examined...
December 2, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/27909719/the-expression-and-function-of-epithelial-membrane-protein-1-in-laryngeal-carcinoma
#7
Hong Li, Xiaowen Zhang, Xuejun Jiang, Xu Ji
In this study, we compared the expression of epithelial membrane protein 1 (EMP1) on the steady-state mRNA level (by quantitative real-time PCR) and on the protein level (by western immunoblot and immunohistochemistry) in 51 pairs of laryngeal carcinoma tissues and matched cancer-free peritumor tissues, and we analyzed the correlation between EMP1 expression and different clinicopathological factors. Furthermore, we ectopically expressed EMP1 in human laryngeal carcinoma Hep-2 cells and examined the effects on cell viability, apoptosis, colonogenicity, and motility, by MTT assay, flow cytometry, colony formation assay and Transwell migration assay, respectively...
November 28, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27906459/integrative-genomic-analysis-identifies-ancestry-related-expression-quantitative-trait-loci-on-dna-polymerase-%C3%AE-and-supports-the-association-of-genetic-ancestry-with-survival-disparities-in-head-and-neck-squamous-cell-carcinoma
#8
Meganathan P Ramakodi, Karthik Devarajan, Elizabeth Blackman, Denise Gibbs, Danièle Luce, Jacqueline Deloumeaux, Suzy Duflo, Jeffrey C Liu, Ranee Mehra, Rob J Kulathinal, Camille C Ragin
BACKGROUND: African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival. METHODS: Ancestry-informative SNPs, RNA sequencing, methylation, and copy number variation data for 316 oral cavity and laryngeal cancer patients were analyzed across 178 DNA repair genes...
December 1, 2016: Cancer
https://www.readbyqxmd.com/read/27902867/predictive-factors-and-treatment-outcome-of-laryngeal-carcinoma-recurrence
#9
Aaro Haapaniemi, Janne Väisänen, Timo Atula, Olli-Pekka Alho, Antti Mäkitie, Petri Koivunen
BACKGROUND: Up to 30% of patients with laryngeal squamous cell carcinoma (SCC) present with recurrence after treatment. We analyzed factors associated with the risk of cancer recurrence and prognosis after recurrence. METHODS: A nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005 with initial successful therapy (n = 316) was analyzed. RESULTS: Laryngeal SCC recurred in 22% of patients. The median time to recurrence was 9 months, with 90% occurring within 36 months after treatment...
November 30, 2016: Head & Neck
https://www.readbyqxmd.com/read/27895741/the-prognostic-significance-of-estrogen-receptor-%C3%AE-in-head-and-neck-squamous-cell-carcinoma
#10
Kresimir Grsic, Iva Ledinsky Opacic, Sanda Sitic, Marija Milkovic Perisa, Petar Suton, Bozena Sarcevic
Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer in the world. Although multimodal and targeted therapy is now used in therapeutic procedures, the survival of patients with HNSCC has remained unchanged over the last 30 years. A number of studies have demonstrated that the increased expression of intranuclear ERβ in breast, lung and colon cancer is a favorable prognostic marker associated with higher survival rates. However, the clinical significance of sex hormone receptors in HNSCC remains unclear...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27891275/tortuous-carotid-artery-extended-to-neck-level-iib-mimicking-the-metastatic-mass
#11
Lokman Uzun, Oğuz Kadir Eğilmez, M Tayyar Kalcioglu, Muhammet Tekin
Specifically in neck level IIb, the expected normal anatomy does not contain any vital structures and consequently it might direct a surgeon to perform rapid surgical dissection of tissues. Therefore aberrant anatomy of the vessels in the patients may be overlooked during neck dissection. Unexpected and potentially devastating injuries can be avoided by respecting the possible aberrant anatomy in any level of the neck. In this case report, a 74-year-old man was presented with laryngeal carcinoma who was treated with laryngectomy and bilateral neck dissection...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27882053/hypoxia-inducible-factor-1%C3%AE-expression-in-indonesian-laryngeal-squamous-cell-carcinoma-patients
#12
Agus Surono, Priyanto Priyanto, Sagung Rai Indrasari
Objectives. This research aimed to determine the association between hypoxia-inducible factor-1α (HIF-1α) expression and laryngeal squamous cell carcinoma clinical stage. Methods. We retrospectively analyzed paraffin-embedded tissue from 47 laryngeal squamous cell carcinoma (LSCC) patients from 2011 to 2014. HIF-1α expression was analyzed by immunohistochemistry using an anti-HIF-1α mouse monoclonal antibody. The association between HIF-1α expression and clinical stage was analyzed using the chi square test...
2016: Journal of Oncology
https://www.readbyqxmd.com/read/27880721/inhibition-of-hax-1-by-mir-125a-reverses-cisplatin-resistance-in-laryngeal-cancer-stem-cells
#13
Jiajia Liu, Qinglai Tang, Shisheng Li, Xinming Yang
Chemoresistance is a major obstacle in chemotherapy of laryngeal carcinoma. Recently, studies indicate that cancer stem cells are responsible for chemotherapy failure. In addition, microRNAs play important roles in tumor initiation, development and multidrug resistance. In the present study, we found that the expression of microRNA-125a was decreased in laryngeal carcinoma tissues and Hep-2 laryngeal cancer stem cells (Hep-2-CSCs). MicroRNA-125a gain-of-function significantly increased the sensitivity of Hep-2-CSCs to cisplatin in vitro and in vivo...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27876461/neutrophil-infiltration-mediated-by-cxcl5-accumulation-in-the-laryngeal-squamous-cell-carcinoma-microenvironment-a-mechanism-by-which-tumour-cells-escape-immune-surveillance
#14
Duo Zhang, Jian Zhou, Di Tang, Lin Zhou, Liang Chou, Kuang-Yen Chou, Lei Tao, Li-Ming Lu
The CXCL5 chemokine is important for neutrophil accumulation in tumour tissues. In this report, we attempted to clarify whether and how infiltrating tumour-associated neutrophils (TANs) in laryngeal squamous cell carcinoma (LSCC) affect the proliferation and activation of T cells. We examined chemokine expression by real-time PCR (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) and performed an immunohistochemical analysis of LSCC microarrays. The relationship between CXCL5 and CD66b (a neutrophil marker) was investigated by immunofluorescence staining...
November 19, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27874955/expression-and-significances-of-mirna-let-7-and-hmga2-in-laryngeal-carcinoma
#15
F-C Song, Y Yang, J-X Liu
OBJECTIVE: High mobility group protein A2 (HMGA2) is a reported new oncogene been regulated by tumor suppressor microRNA Let-7. HMGA2 has become a hot topic in fundamental and clinical research of laryngeal carcinoma. The aim of the current study is to investigate the molecular mechanism of Let-7 and HMGA2 in oncogenesis and progression of laryngeal cancer. PATIENTS AND METHODS: We used quantitative RT-PCR to detect the expression of miRNA Let-7a and HMGA2 mRNA from 59 pairs of fresh laryngeal cancer tissues and adjacent tissues collected for the laryngeal cancer patient...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27868407/-effect-of-dj-1-silencing-by-rna-interference-on-growth-of-xenografted-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-in-nude-mice
#16
Zhisen Shen, Hongxia Deng, Dong Ye, Jian Zhang, Shijie Qiu, Qun Li, Xiang Cui
Objective: To investigate the effect of silencing DJ-1 on xenografted human laryngeal squamous cell carcinoma (LSCC) Hep-2 cells in nude mice. Methods: Xenograft model of human LSCC was established by subcutaneous transplantation of Hep-2 cells in 24 nude mice. The LSCC-bearing nude mice were randomly divided into 3 groups (n=8 in each):DJ-1 siRNA low dose group and DJ-1 siRNA high dose group were injected in tumors with 20 μg of DJ-1 siRNA or 40 μg of DJ-1 siRNA in 50 μL, respectively; control group was injected with 5% glucose solution in 50 μL, twice a week for 3 weeks...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27867556/recurrent-laryngeal-nerve-lymph-node-dissection-may-not-be-suitable-for-all-early-stage-esophageal-squamous-cell-carcinoma-patients-an-8-year-experience
#17
Shaobin Yu, Jihong Lin, Chenshu Chen, Jiangbo Lin, Ziyang Han, Wenwei Lin, Mingqiang Kang
BACKGROUND: Recurrent laryngeal nerve (RLN) injury is one of the most frequent postoperative complications of esophageal squamous cell carcinoma (ESCC) radical resection. This study aims to develop a novel scoring system to predict recurrent laryngeal nerve lymph node (RLNLN) metastases in early ESCC and explore the indications for precise RLN lymphadenectomy. METHODS: Early stage ESCC patients from 2006 to 2014 were analyzed. Patient and pathologic characteristics were compared between patients with RLNLN metastases and those without...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27863075/transoral-laser-microsurgery-versus-radiotherapy-for-t2-glottic-squamous-cell-carcinoma-a-systematic-review-of-local-control-outcomes
#18
L Warner, K Lee, J J Homer
BACKGROUND: Systematic reviews comparing treatment of early glottic cancer with transoral surgery or radiotherapy demonstrate similar oncological outcomes. Most studies of "early stage" laryngeal cancer include Tis, T1a, T1b and T2 cases. The data is dominated by patients with T1 and Tis tumours, although extrapolating these results and applying them for T2 cases may be inappropriate. No previous systematic reviews have focused on T2 cancers as a separate group. OBJECTIVE OF REVIEW: This review compares local control outcomes for T2 glottic squamous cell carcinoma, treated with transoral microsurgery or external beam radiotherapy...
November 10, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27859417/runx3-inhibits-laryngeal-squamous-cell-carcinoma-malignancy-under-the-regulation-of-mir-148a-3p-dnmt1-axis
#19
Su Jili, Lu Eryong, Lu Lijuan, Zhang Chao
Laryngeal squamous cell carcinoma (LSCC) is a highly aggressive malignant cancer and accounts for 1% to 2% of all malignancies diagnosed worldwide. Runt-related transcription factor 3 (RUNX3), an important tumor suppressor, is known to related to lymph node metastasis and the development of LSCC. However, the biological roles and potential mechanisms RUNX3 expression was not well understood. In this study, we reported that the RUNX3 was significantly downregulated and highly methylated in LSCC compared with their matched normal...
November 15, 2016: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/27855370/cd47-is-a-potential-target-for-the-treatment-of-laryngeal-squamous-cell-carcinoma
#20
ChunPing Yang, ShuFeng Gao, HaiZhen Zhang, Lian Xu, JianGuo Liu, Meiqun Wang, ShaoRong Zhang
BACKGROUND/AIMS: This study aims to investigate the effect of CD47 on the development of laryngeal squamous cell carcinoma (LSCC) and the therapeutic potential of monoclonal antibody against CD47 and its ligand SIRPα in the treatment of LSCC. METHODS: We firstly detected the expressions of CD47 mRNA and protein in LSCC and para-carcinoma tissues, introduced the most efficient CD47siRNA sequence into LSCC cells by lentiviral transfection and employed three monoclonal antibodies to evaluate their anti-LSCC effects in vitro and in vivo...
2016: Cellular Physiology and Biochemistry
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