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https://www.readbyqxmd.com/read/29344234/an-oncogenic-function-of-retinoic-acid-receptor-%C3%AE-in-the-development-of-laryngeal-squamous-cell-carcinoma
#1
Cheng-Fu Cai, Cun-Shan Liu, Han-Jing Shang-Guan, Cai-Hong Yang, Xian-Yang Luo, Dong-Yan Shen, Shu-Yu Yang
The aberrant expression of retinoic acid receptor-α (RARα) has been reported in various types of cancer. However, its association with the prognosis and development of laryngeal squamous cell carcinoma (LSCC) has not yet been determined. Therefore, the present study aimed to examine the expression and function of RARα in patients with LSCC. The expression of RARα in LSCC tissues was investigated using immunostaining. An MTT assay and flow cytometry analysis were also performed to investigate the function of RARα in the proliferation and cell cycle of LSCC cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29335520/hpv16-e6-and-e7-upregulate-the-histone-lysine-demethylase-kdm2b-through-the-c-myc-mir-146a-5p-axys
#2
Elektra Peta, Alessandro Sinigaglia, Giulia Masi, Barbara Di Camillo, Angela Grassi, Marta Trevisan, Lorenzo Messa, Arianna Loregian, Erminia Manfrin, Matteo Brunelli, Guido Martignoni, Giorgio Palù, Luisa Barzon
Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an important role in the development of cancer, including HPV-related tumors. In this study, we demonstrated that miR-146a-5p was down-regulated by E6 and, less efficiently, by E7 of high-risk HPV16 in keratinocytes and the presence of low levels of this miRNA in cervical carcinoma cell lines and in high-risk HPV-positive cervical specimens...
January 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29332349/characteristics-and-clinical-significance-of-recurrent-laryngeal-nerve-lymph-node-metastasis-in-esophageal-squamous-cell-carcinoma
#3
Longfei Ma, Jiaqing Xiang, Yawei Zhang, Hong Hu, Rongrong Shao, Dong Lin
PURPOSE: The recurrent laryngeal nerve lymph nodes (RLN LNs) are among the most common metastatic sites in esophageal cancer, and the dissection of these lymph nodes (LNs) is considered beneficial. The purpose of this study was to evaluate the characteristics of RLN LN metastases from esophageal squamous cell carcinoma, and the effects of these metastases on the prognosis of patients. In addition, we aimed to determine the reasonable range of dissection of regional LNs. METHODS: The clinical data from 348 patients who underwent resection for esophageal carcinoma were retrospectively analyzed...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332170/mirna-mrna-crosstalk-in-laryngeal-squamous-cell-carcinoma-based-on-the-tcga-database
#4
Guan-Jiang Huang, Meng-Si Luo, Guo-Ping Chen, Min-Yi Fu
BACKGROUND: The functional characterization of non-coding microRNAs (miRNAs) has been shown to be associated with the pathophysiology of the disease, but it is still a challenging task to elucidate the pathogenesis of microRNAs and disease. In addition, the understanding of the role of miRNAs in the development of LSCC still needs further exploration. MATERIALS AND METHODS: In this study, to identify miRNAs that play a key role in LSCC, we analyzed miRNA and mRNA sequence data from 162 LSCC samples from the TCGA database, and screened specific miRNAs and mRNAs by differential gene expression analysis...
January 13, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29331266/human-papilloma-virus-specific-t-cells-can-be-generated-from-na%C3%A3-ve-t-cells-for-use-as-an-immunotherapeutic-strategy-for-immunocompromised-patients
#5
Sarah E McCormack, Conrad Russell Y Cruz, Kaylor E Wright, Allison B Powell, Haili Lang, Cornelia Trimble, Michael D Keller, Ephraim Fuchs, Catherine M Bollard
Human papilloma virus (HPV) is a known cause of cervical cancer, squamous cell carcinoma and laryngeal cancer. Although treatments exist for HPV-associated malignancies, patients unresponsive to these therapies have a poor prognosis. Recent findings from vaccine studies suggest that T-cell immunity is essential for disease control. Because Epstein-Barr Virus (EBV)-specific T cells have been highly successful in treating or preventing EBV-associated tumors, we hypothesized that the development of a manufacturing platform for HPV-specific T cells from healthy donors could be used in a third-party setting to treat patients with high-risk/relapsed HPV-associated cancers...
January 10, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29328423/cetuximab-enhances-cisplatin-induced-endoplasmic-reticulum-stress-associated-apoptosis-in-laryngeal-squamous-cell-carcinoma-cells-by-inhibiting-expression-of-txndc5
#6
Fusen Peng, Hailin Zhang, Youhong Du, Pingqing Tan
Cisplatin and cetuximab, an anti‑epidermal growth factor receptor (EGFR) monoclonal humanized antibody, have been used for treatment of laryngeal squamous cell carcinoma (LSCC). It has been demonstrated that cisplatin and inhibition of EGFR signaling may induce endoplasmic reticulum (ER) stress‑associated apoptosis. However, ER protein thioredoxin domain‑containing protein 5 (TXNDC5) reportedly protects cells from ER stress‑associated apoptosis. The present study investigated the interaction between cisplatin, cetuximab and TXNDC5 on ER stress‑associated apoptosis in LSCC cells...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327732/a-mirna-signature-suggestive-of-nodal-metastases-from-laryngeal-carcinoma
#7
F Ricciardiello, R Capasso, H Kawasaki, T Abate, F Oliva, A Lombardi, G Misso, D Ingrosso, C A Leone, M Iengo, M Caraglia
The discovery that miRNAs are frequently deregulated in tumours offers the opportunity to identify them as prognostic and diagnostic markers. The aim of this multicentric study is to identify a miRNA expression profile specific for laryngeal cancer. The secondary endpoint was to identify specific deregulated miRNAs with potential as prognostic biomarkers for tumour spread and nodal involvement, and specifically to search for a miRNA pattern pathognomonic for N+ laryngeal cancer and for N- tissues. We identified 20 miRNAs specific for laryngeal cancer and a tissue-specific miRNA signature that is predictive of lymph node metastases in laryngeal carcinoma characterised by 11 miRNAs, seven of which are overexpressed (upregulated) and four downregulated...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29322787/beclin1-enhances-cisplatin-induced-apoptosis-via-bcl-2-modulated-autophagy-in-laryngeal-carcinoma-cells-hep-2
#8
M Yang, X M Yang, D H Yin, Q L Tang, L Wang, C Huang, P Li, S S Li
To investigate the role of Beclin1 in cisplatin-induced apoptosis in laryngeal carcinoma cells Hep-2 and to explore the potential mechanism. We up-regulated Beclin1 expression in Hep-2 cells. The survival rate and apoptotic rate were evaluated by MTT and flow cytometry (FCM). The Beclin1 overexpression group and the control group were treated with cisplatin for 24 hours. The proliferation and cell apoptosis of laryngeal cancer cell lines were evaluated. The mitochondrial membrane potentials were detected by DiOC6(3)...
2018: Neoplasma
https://www.readbyqxmd.com/read/29307338/expression-of-mir-373-and-its-predicted-target-genes-e-cadherin-and-cd44-in-patients-with-laryngeal-squamous-cell-carcinoma
#9
Özlem Timirci-Kahraman, Ayşegül Verim, Ammad Ahmad Farooqi, Saime Turan, Nazli Ezgi Özkan-Küçük, İlhan Yaylim
Laryngeal squamous cell carcinoma (LSCC) is a genomically complex disease that is difficult to target, and efforts have been made to identify new treatment strategies and   molecular markers that might stratify patients and individualize options for treatment. miR-373 has diametrically opposed roles in different stages and types of cancers. miR-373 has been suggested to quantitatively control E-cadherin and CD44 expression. We studied the expression of miR-373, E-cadherin and CD44 in laryngeal squamous cell carcinoma and evaluated the association between the disease and clinical characteristics of patients...
December 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29302639/minimally-invasive-esophagectomy-via-sweet-approach-in-combination-with-cervical-mediastinoscopy-for-esophageal-squamous-cell-carcinoma-a-case-series
#10
Wenxiang Wang, Baihua Zhang, Xu Li, Jie Wu, Zhining Wu, Yan Ding, Desong Yang, Jinming Tang, Min Su, Junliang Ma, Xianman You, Jianping Liang, Yong Zhou
Objective: Minimally invasive esophagectomy (MIE) is increasingly used for the treatment of esophageal cancer. However, MIE via the Sweet approach has seldom been reported owing to the challenging procedure for a mediastinal lymph node. Thus, the approach of MIE via left-sided thoracoscopy coupled with video-assisted cervical mediastinoscopy (MIE-SM) was explored for eradicating the mediastinal lymph nodes and recurrent laryngeal nerve; the incidence of perioperative complications, mortality, and surgical radicality were analyzed...
December 2017: International Journal of Surgery. Oncology
https://www.readbyqxmd.com/read/29299511/detection-of-cartilage-invasion-in-laryngeal-carcinoma-with-dynamic-contrast-enhanced-ct
#11
Jan W Dankbaar, Jaap Oosterbroek, Elise A Jager, Hugo W de Jong, Cornelis P Raaijmakers, Stefan M Willems, Chris H Terhaard, Marielle E Philippens, Frank A Pameijer
Objective: Staging of laryngeal cancer largely depends on cartilage invasion. Presence of cartilage invasion affects treatment choice and prognosis. On MRI and contrast-enhanced CT (CECT) it may be challenging to differentiate cartilage invasion from inflammation. The purpose of this study is to compare the diagnostic properties of dynamic contrast-enhanced CT (DCECT) and CECT for visual detection of cartilage invasion in laryngeal cancer. Study Design: Prospective cohort study...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29290320/-sarcomatoid-carcinoma-of-larynx-a-histological-challenge
#12
Alejandra Osorio-Velásquez, Carlos M Chiesa-Estomba, Frank A Betances-Reinoso, M Pilar San Miguel-Fraile, José A Ortiz-Rey
INTRODUCTION: Sarcomatoid carcinoma can occur in any part of the body; in the head and neck it occurs most frequently in the major salivary glands, with only about 1% of cases found in the larynx. As it has both epithelial and mesenchymal components, there are many theories concerning its origin and it can prove a diagnostic challenge. CASE REPORT: A 76 year old male smoker presented with dysphonia. Vocal cord injury was found on examination but no lymphadenopathy or metastases were present...
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29285357/utility-of-chemoradioselection-for-the-optimization-of-treatment-intensity-in-advanced-hypopharyngeal-and-laryngeal-carcinoma
#13
Muneyuki Masuda, Takahiro Wakasaki, Satoshi Toh, Yoshinori Uchida, Hidefumi Rikimaru, Naonobu Kunitake, Yuichiro Higaki
Definitive concomitant chemoradiotherapy (CRT) with high-dose cis-platinum (CDDP) is a current standard protocol for advanced laryngeal and hypopharyngeal cancer sparing surgery for salvage. However, this modality is associated with limited feasibility and frequent sever toxicities. In the present study, a 'chemoradioselection' protocol with minimal toxicity was developed using initial response to CRT as a biomarker for patient selection. Between 2000, March and 2012, September 123 patients with stage III (44), IV (79) laryngeal (64) and hypopharyngeal carcinoma (59) excluding T4 cases were enrolled to this protocol...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29285166/annexin-a2-is-an-independent-prognostic-biomarker-for-evaluating-the-malignant-progression-of-laryngeal-cancer
#14
Shi Luo, Chubo Xie, Ping Wu, Jian He, Yaoyun Tang, Jing Xu, Suping Zhao
Due to the lack of a definite diagnosis, a frequent recurrence rate and resistance to chemotherapy or radiotherapy, the clinical outcome for patients with advanced laryngeal cancer has not improved over the last decade. Annexin A2 is associated with the invasion and metastasis of cancer cells. In the present study, it was demonstrated using differential proteomics analysis that Annexin A2 is highly expressed in laryngeal carcinoma tissues and this was confirmed using immunohistochemistry, which demonstrated that the expression of Annexin A2 in laryngeal carcinoma tissues was significantly higher than in healthy adjacent tissue...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29280495/tsr2-induces-laryngeal-cancer-cell-apoptosis-through-inhibiting-nf-%C3%AE%C2%BAb-signaling-pathway
#15
Hong-Jiang He, Han Bing, Guijun Liu
OBJECTIVES/HYPOTHESIS: Human laryngeal squamous cell carcinoma (LSCC) is a malignancy that was discovered originally in the epithelial tissue of laryngeal mucosa. However, the underlying molecular mechanism is still not clear. In this study, we aimed to investigate the potential molecular mechanisms of TSR2 in the LSCC cell apoptosis. STUDY DESIGN: The expression of TSR2 was first analyzed in LSCC tissues. Then functional effects of TSR2 on Hep-2 and AMC-HN-8 cell lines were performed by overexpression pcDNA3...
December 27, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29278752/cost-effectiveness-analysis-in-papillary-thyroid-carcinoma-patients-with-different-neck-dissection-strategy-a-retrospective-cohort-study
#16
Kai Guo, Xiaoke Zheng, Duanshu Li, Yi Wu, Qinghai Ji, Zhuoying Wang
BACKGROUND: There are two surgical strategies for bilateral neck dissection (BND), simultaneous and two-stage operations. The aim of the study was to compare the cost-effectiveness BND with this two operations in papillary thyroid carcinoma (PTC) patients. MATERIALS AND METHODS: Consecutive PTC patients undergoing BND were studied retrospectively, and were classified into simultaneous group (Group A) and two-stage group (Group B). Demographic, medical costs, complication and surgical variables were recorded...
December 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29278552/oncologic-and-functional-outcomes-of-patients-treated-with-transoral-co2-laser-microsurgery-or-radiotherapy-for-t2-glottic-carcinoma-a-systematic-review-of-the-literature
#17
Martine Hendriksma, Bas J Heijnen, Elisabeth V Sjögren
PURPOSE OF REVIEW: To give an overview of the laryngeal preservation and functional outcomes of patients treated with transoral CO2 laser microsurgery (TLM) or radiotherapy for T2 glottic carcinoma. This information supports physicians and patients in treatment counselling and choices. RECENT FINDINGS: A recent systematic review showed that local control rates at 5-year did not differ between radiotherapy and TLM for T2 glottic tumours. However, there is a lack of comparative data on laryngeal preservation as well as functional outcomes in T2 glottic carcinoma...
December 22, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29277379/lymph-node-metastasis-following-total-laryngectomy-and-total-pharyngolaryngectomy-for-laryngeal-and-hypopharyngeal-squamous-cell-carcinoma-frequency-distribution-and-risk-factors
#18
D Rivière, J Mancini, L Santini, A Giovanni, P Dessi, N Fakhry
OBJECTIVES: To evaluate the prevalence and distribution of lymph-node metastasis after total laryngectomy or total pharyngolaryngectomy. MATERIAL AND METHODS: Retrospective single-center series of 136 successive patients undergoing total laryngectomy or total pharyngolaryngectomy with neck dissection for squamous cell carcinoma of the larynx or hypopharynx. RESULTS: The primary site was laryngeal in 110 cases and hypopharyngeal in 26. In 63 patients, surgery was first-line treatment; 73 were operated on for recurrence...
December 22, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29275426/platelet-to-lymphocyte-ratio-predicts-long-term-survival-in-laryngeal-cancer
#19
Yize Mao, Yan Fu, Yunfei Gao, Ankui Yang, Quan Zhang
OBJECTIVES: Although the survival rate of laryngeal cancer is relatively high, some patients with laryngeal squamous cell carcinoma (LSCC) show the least benefit from laryngectomy, owing to few determining diagnostic tools. We aimed to identify high-risk patients according to a preoperatively determined signature of the platelet-to-lymphocyte ratio (PLR) of > 193.55, as an indicator of poor treatment outcome in LSCC patients. METHODS: We retrospectively evaluated 899 patients who underwent laryngectomy for LSCC...
December 23, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29262452/-expression-and-correlation-of-fra-1-and-hmga1-in-laryngeal-squamous-cell-carcinoma
#20
Y L Zhang, X F Song, Y J Duan, R L Zhao
Objective: To investigate the expressions of Fra-1 and HMGA1 in laryngeal squamous cell carcinoma and their correlation. Methods: Immunohistochemistry and reverse transcription-polymer chain reaction (RT-PCR) were used to detect the expressions of HMGA1 and Fra-1 in laryngeal squamous carcinoma tissues in 47 cases and para-carcinoma tissues in 21 cases(the First Hospital of Shijiazhuang). The relationship between the gene expressions in carcinoma tissues and clinopathological parameters such as pathological grade, clinical stage, lymph metastasis, age and anatomic site and the relevance of the two gene expressions were analyzed...
December 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
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