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https://www.readbyqxmd.com/read/27619191/combined-ankle-foot-energetics-are-conserved-when-distal-foot-energy-absorption-is-minimized
#1
Elisa S Arch, Bretta L Fylstra
The large, late-stance energy generated by the ankle is believed to be critical during gait. However, the distal foot absorbs/dissipates a considerable amount of energy during the same phase. Thus, the energy generated by the combined ankle-foot system is more modest, which raises questions regarding the necessity of such a large ankle power and the interplay between foot and ankle energetics. This study aimed to evaluate our conservation of energy hypothesis, which predicted if distal foot energy absorption/dissipation was reduced, less energy would be generated at the ankle and thus the same combined ankle-foot energetics would be achieved...
September 6, 2016: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/27228405/comparative-proteomic-analysis-of-whole-gut-lavage-fluid-and-pancreatic-juice-reveals-a-less-invasive-method-of-sampling-pancreatic-secretions
#2
Jana M Rocker, Marcus C Tan, Lee W Thompson, Carlo M Contreras, Jack A DiPalma, Lewis K Pannell
OBJECTIVES: There are currently no reliable, non-invasive screening tests for pancreatic ductal adenocarcinoma. The fluid secreted from the pancreatic ductal system ("pancreatic juice") has been well-studied as a potential source of cancer biomarkers. However, it is invasive to collect. We recently observed that the proteomic profile of intestinal effluent from the bowel in response to administration of an oral bowel preparation solution (also known as whole-gut lavage fluid, WGLF) contains large amounts of pancreas-derived proteins...
May 26, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/26516351/pedobarographic-and-kinematic-analysis-in-the-functional-evaluation-of-two-post-operative-forefoot-offloading-shoes
#3
Paolo Caravaggi, Alessia Giangrande, Lisa Berti, Giada Lullini, Alberto Leardini
BACKGROUND: Forefoot offloading shoes are special orthopaedic footwear designed to protect and unload the injured part of the foot after surgery and for conservative treatments. The offloading action is often achieved by transferring plantar load to the rearfoot via rocker shoes with reduced contact area between shoe and ground. While these shoes are intended to be worn only for short periods, a compromise must be found between functionality and the risk of alterations in gait patterns at the lower limb joints...
2015: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/25624422/use-of-an-online-portal-to-facilitate-clinical-trial-recruitment-a-preliminary-analysis-of-fox-trial-finder
#4
Charlotte Rocker, Lily Cappelletti, Claudia Marshall, Claire C Meunier, Deborah W Brooks, Todd Sherer, Sohini Chowdhury
BACKGROUND: As in other therapeutic areas, clinical studies in Parkinson's disease (PD) face significant recruitment challenges. However, qualitative surveys suggest that individuals with PD are willing to participate in clinical research. The Michael J. Fox Foundation therefore established Fox Trial Finder in 2011 to facilitate connection between PD research teams and volunteers. OBJECTIVE: Characterize the research volunteers (with and without PD) registered on Fox Trial Finder as of June 2014, and the published, recruiting studies to identify trends and highlight gaps between research requirements and available volunteers...
2015: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/24370440/effect-of-rocker-shoes-on-plantar-pressure-pattern-in-healthy-female-runners
#5
COMPARATIVE STUDY
Sobhan Sobhani, Edwin van den Heuvel, Steef Bredeweg, Bas Kluitenberg, Klaas Postema, Juha M Hijmans, Rienk Dekker
Rocker profile shoes (rocker shoes) are one of the treatment options of metatarsalgia and forefoot stress fractures. The efficacy of rocker shoes in unloading the forefoot pressure has been shown in walking. In running, however, the effect of rocker shoes on forefoot pressure is unknown. Eighteen healthy female runners participated in this study. In-shoe plantar pressures were recorded during running with the standard running shoes and rocker shoes. Shoe comfort was assessed after each shoe measurement. Peak pressure (PP), maximum mean pressure (MMP) and force-time integral (FTI) were determined for seven foot areas...
March 2014: Gait & Posture
https://www.readbyqxmd.com/read/23401295/effects-of-the-heel-to-toe-rocker-sole-on-walking-in-able-bodied-persons
#6
COMPARATIVE STUDY
Mokhtar Arazpour, Stephen W Hutchins, Farhad T Ghomshe, Fahimeh Shaky, Masome V Karami, Andrey Y Aksenov
BACKGROUND AND AIM: The most commonly prescribed external shoe modification is the use of rocker soles. The aim of this study was to evaluate the effect of a heel-to-toe rocker sole profile on specific temporal-spatial parameters and the kinematics of walking when added to footwear. METHOD: Seventeen healthy adult volunteers participated in this study. For each subject, gait analysis was performed under two conditions that were tested in a random order: walking with either a baseline shoe with a flat sole or a modified shoe adapted with a heel-to-toe rocker sole...
December 2013: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/22151192/an-investigation-of-the-effect-of-modifying-stimulation-profile-shape-on-the-loading-response-phase-of-gait-during-fes-corrected-drop-foot-stimulation-profile-and-loading-response
#7
Thomas O'Halloran, Morten Haugland, Gerard M Lyons, Thomas Sinkjaer
Drop foot stimulators today operate open loop with a trapezoidal stimulation profile. The traditionally applied profile originated as much from technological constraints as suitability for the physical pathology. It was proposed that by increasing the stimulation intensity during the loading response phase of gait, the ankle angle trajectory would become closer to that of normal gait and a more efficient heel rocker would be introduced. One patient, who used an implanted stimulator, was tested. Various profiles, which provided increased stimulation during loading response, were tried and joint angle trajectories, electromyograms, and footswitches were recorded...
April 2004: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/22076094/rocker-bottom-profile-type-shoes-do-not-increase-lower-extremity-muscle-activity-or-energy-cost-of-walking
#8
Antonio S Santo, Jenevieve L Roper, Janet S Dufek, John A Mercer
The purpose of this study was to determine if wearing rocker-bottom shoes with compliant midsoles (RB) influences muscle activity and metabolic cost of walking. Furthermore, we sought to determine if weight differences between shod conditions accounted for any potential change. Twenty-eight subjects (17 women, 11 men, age 22.8 ± 6.6 years; weight 72 ± 20 kg; height 170 ± 6.7 cm; percent body fat 23.0 ± 11.7) walked on a treadmill (0% grade) for 10 minutes at a self-selected speed plus 10% (1.3 ± 0.2 m·s) in each of the following laboratory-provided shoes: flat-bottomed shoe (W), flat-bottomed shoe weight-matched to RB (WM), and RB...
September 2012: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/21521160/gait-related-strategies-for-the-prevention-of-plantar-ulcer-development-in-the-high-risk-foot
#9
REVIEW
Frank L Bowling, Neil D Reeves, Andrew J Boulton
High plantar pressures lead to ulceration in the diabetic foot, particularly in the forefoot region around the metatarsal heads. High plantar pressures persist during gait due to factors such as peripheral neuropathy, foot deformities, limited ankle dorsi flexion range of motion and reduced plantar tissue thickness. Strategies impinging upon gait such as the use of appropriate therapeutic footwear, custom-moulded insoles and injectable silicone can help to reduce plantar pressures and attenuate the risk for ulceration...
May 2011: Current Diabetes Reviews
https://www.readbyqxmd.com/read/20382279/effects-of-combining-electric-stimulation-with-active-ankle-dorsiflexion-while-standing-on-a-rocker-board-a-pilot-study-for-subjects-with-spastic-foot-after-stroke
#10
RANDOMIZED CONTROLLED TRIAL
Ju-Shao Cheng, Yea-Ru Yang, Shih-Jung Cheng, Pei-Yi Lin, Ray-Yau Wang
OBJECTIVE: To investigate the therapeutic effects of combining electric stimulation (ES) with active ankle dorsiflexion while standing on a rocker board in subjects with plantarflexor spasticity after stroke. DESIGN: Randomized controlled trial. SETTING: A rehabilitation medical center. PARTICIPANTS: Subjects (N=15) with spastic foot after stroke. INTERVENTIONS: Subjects were randomly assigned to an experimental or a control group...
April 2010: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/20307470/the-biomechanics-and-clinical-efficacy-of-footwear-adapted-with-rocker-profiles-evidence-in-the-literature
#11
S Hutchins, P Bowker, N Geary, J Richards
BACKGROUND: Rocker profiles are the most commonly prescribed external therapeutic shoe modification. However, the prescription criteria for rocker profiles have historically been based on theoretical considerations with minimal scientific study and validation. OBJECTIVE: Rocker profiles are used to afford pressure relief for the plantar surface of the foot, to limit the need for sagittal plane motion in the joints of the foot and to alter gait kinetics and kinematics in proximal joints...
September 2009: Foot
https://www.readbyqxmd.com/read/19083608/treatment-of-charcot-foot-and-ankle-with-a-prefabricated-removable-walker-brace-and-custom-insole
#12
Shawn Verity, Michael Sochocki, John M Embil, Elly Trepman
BACKGROUND: Removable walker braces have been used successfully to treat acute and chronic foot and ankle conditions including diabetic foot ulcers. We hypothesized that a removable walker brace may be successfully used in the management of the Charcot foot and ankle. METHODS: Twenty-five feet and ankles with Charcot arthropathy in 21 patients (bilateral in 4 patients) were treated with a prefabricated, pneumatic removable walker brace fitted with a custom orthotic insole...
2008: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/18362803/idiopathic-toe-walking-a-kinematic-and-kinetic-profile
#13
David E Westberry, Jon R Davids, Roy B Davis, Mauro César de Morais Filho
PURPOSE: The differential diagnosis in children who walk on their toes includes mild spastic diplegia and idiopathic toe walking (ITW). A diagnosis of ITW is often one of exclusion. To better characterize the diagnosis of ITW, quantitative gait analysis was utilized in a series of patients with an established diagnosis of ITW. STUDY DESIGN: Patients with an established diagnosis of ITW were analyzed by quantitative gait analysis. Data were recorded as each subject walked in a self-selected toe-walking pattern...
April 2008: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/17389127/a-review-of-neurocognitive-and-behavioral-profiles-associated-with-22q11-deletion-syndrome-implications-for-clinical-evaluation-and-treatment
#14
REVIEW
Opal Ousley, Kimberly Rockers, Mary Lynn Dell, Karlene Coleman, Joseph F Cubells
22q11 deletion syndrome (22q11DS) is a chromosomal disorder that results in variable multisystem abnormalities, including conotruncal cardiac malformations, aplasia or hypoplasia of the thymus and/or parathyroid glands, immunodeficiency, dysmorphic facial features, and cleft palate and other nasopharyngeal and dental anomalies. Individuals with 22q11DS also exhibit cognitive and behavioral difficulties, including delayed motor and speech-language development, mental retardation, low academic achievement, impaired spatial reasoning, poor attentional and executive functioning, attention-deficit hyperactivity disorder, autism spectrum disorders, mood disorders, and/or schizophrenia spectrum disorders...
April 2007: Current Psychiatry Reports
https://www.readbyqxmd.com/read/15146389/a-hox-gene-mutation-in-a-family-with-isolated-congenital-vertical-talus-and-charcot-marie-tooth-disease
#15
Antony E Shrimpton, E Mark Levinsohn, Justin M Yozawitz, David S Packard, Robert B Cady, Frank A Middleton, Antonio M Persico, David R Hootnick
Congenital vertical talus (CVT), also known as "rocker-bottom foot" deformity, is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity. The reported familial cases are consistent with an autosomal dominant mode of inheritance with incomplete penetrance. In contrast, Charcot-Marie-Tooth disease (CMT) is thought to be a completely distinct heterogeneous group of disorders, with foot abnormalities that typically develop a high-arched "claw foot" appearance later in life...
July 2004: American Journal of Human Genetics
https://www.readbyqxmd.com/read/7826431/immediate-physiological-responses-of-healthy-volunteers-to-different-types-of-music-cardiovascular-hormonal-and-mental-changes
#16
RANDOMIZED CONTROLLED TRIAL
M Möckel, L Röcker, T Störk, J Vollert, O Danne, H Eichstädt, R Müller, H Hochrein
A group of 20 healthy volunteers [10 women, 10 men; median age 25 (20-33) years] were examined by means of pulsed wave Doppler echocardiography, blood sample analysis and psychological testing before and after listening to three different examples of music: a waltz by J. Strauss, a modern classic by H. W. Henze, and meditative music by R. Shankar. To assess small haemodynamic changes, mitral flow, which reflects left ventricular diastolic behaviour, was measured by Doppler ultrasound. Heart rate, arterial blood pressure and plasma concentrations of adrenocorticotropic hormone, cortisol, prolactin, adrenaline, noradrenaline, atrial natriuretic peptide (ANP) and tissue plasminogen activator (t-PA) were determined simultaneously...
1994: European Journal of Applied Physiology and Occupational Physiology
https://www.readbyqxmd.com/read/7539799/a-novel-form-of-dipeptidylpeptidase-iv-found-in-human-serum-isolation-characterization-and-comparison-with-t-lymphocyte-membrane-dipeptidylpeptidase-iv-cd26
#17
COMPARATIVE STUDY
J S Duke-Cohan, C Morimoto, J A Rocker, S F Schlossman
Human CD26, a Type II membrane glycoprotein with intrinsic dipeptidylpeptidase IV (DPPIV) activity and ability to bind adenosine deaminase type I (ADA-1), is expressed on epithelial cells constitutively, but on T lymphocytes its expression is regulated. A soluble form of CD26/DPPIV has been described in plasma and related to immunological status, but it has been defined by the presence of DPPIV activity rather than by isolation. Using nondenaturing chromatographic techniques followed by nondenaturing native preparative electrophoresis, we obtained a homogeneous preparation of soluble serum DPPIV and compared it with a recombinant soluble CD26/DPPIV (rsCD26)...
June 9, 1995: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/3688125/affective-responses-to-keeping-and-not-keeping-an-activity-product
#18
J D Rocker, D L Nelson
This study examined whether keeping or not keeping the products of a craft activity influences affective meaning and mood. Four groups of undergraduate (n = 23) and graduate (n = 20) students created block-printed stationery. Two groups were allowed to keep their stationery, and two groups were not. The measure of mood changes was the Bipolar Profile of Mood States, which subjects completed before and after the activity. After the activity, subjects also completed the Osgood 12-scale short-form semantic differential, which measured the affective meanings of the activity...
March 1987: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/2538063/carbohydrate-metabolism-by-primary-cultures-of-rabbit-proximal-tubules
#19
M J Tang, K R Suresh, R L Tannen
Renal proximal tubular epithelia were used to assess the factors responsible for the induction of glycolysis in cultured cells. Primary cultures of rabbit proximal tubules, which achieved confluency at 6 days, exhibited hormonal responsiveness and brush-border characteristics typical of proximal tubular cells. Beginning at day 4, these cultured cells exhibited increased glycolytic metabolism reflected by enhanced glucose uptake and lactate production, along with parallel increases in activity of the glycolytic enzymes, pyruvate kinase and lactate dehydrogenase...
March 1989: American Journal of Physiology
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