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Alexander V Kofman, Roger Abounader
The paper by Soda et al. provides experimental evidence for the plasticity of glioblasoma multiforme (GBM) cells, specifically their ability to form vascular endothelial cells (ECs). The study demonstrates the existence of tumor-derived ECs (TDECs) in GBM blood vessels of transgenic mice and humans. Blood vessels with TDECs were functional and were more frequently found in hypoxic tumor regions. In vitro hypoxic conditions enhanced the transition of tumor-initiating cells to an endothelial-like morphology and the formation of tube-like structures...
July 2011: Future Oncology
Jaren W Landen, Vincent Hau, Mingshen Wang, Thomas Davis, Brian Ciliax, Bruce H Wainer, Erwin G Van Meir, Johnathan D Glass, Harish C Joshi, David R Archer
The opium alkaloid noscapine is a commonly used antitussive agent available in Europe, Asia, and South America. Although the mechanism by which it suppresses coughing is currently unknown, it is presumed to involve the central nervous system. In addition to its antitussive action, noscapine also binds to tubulin and alters microtubule dynamics in vitro and in vivo. In this study, we show that noscapine inhibits the proliferation of rat C6 glioma cells in vitro (IC(50) = 100 microm) and effectively crosses the blood-brain barrier at rates similar to the ones found for agents such as morphine and [Met]enkephalin that have potent central nervous system activity (P < or = 0...
August 1, 2004: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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