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https://www.readbyqxmd.com/read/29692000/phloroglucinol-derivatives-from-the-fruits-of-eucalyptus-globulus-and-their-cytotoxic-activities
#1
Pham Thi-Anh, Imran Shair Mohammad, Vu Van-Tuan, Hu Xiao-Long, Chaurasiya Birendra, Aftab Ulah, Guo Cui, Lv Xian-Yu, Ye Wen-Cai, Wang Hao
A new phloroglucinol derivative, named Eucalyptin B (1), along with five related known compounds (2-6), was isolated from the fruits of Eucalyptus globulus. Their structures were elucidated by means of 1D and 2D NMR spectroscopy, with the absolute configuration of 1 determined by electronic circular dichroism (ECD) calculations. All isolated compounds (1-6) were evaluated for their cytotoxic activities against lung (A549), breast (4T1), and skin (B16F10) cancer cell lines. On the basis of cytoxicity the antitumor activity of Eucalyptin B (1) was further confirmed by apoptosis assay...
April 24, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29691683/angio-3-a-10-residue-peptide-derived-from-human-plasminogen-kringle-3-suppresses-tumor-growth-in-mice-via-impeding-both-angiogenesis-and-vascular-permeability
#2
Shruthi Venugopal, Chieh Kao, Ritu Chandna, Konerirajapuram N Sulochana, Vivekanandan Subramanian, Mo Chen, R Manjunatha Kini, Ruowen Ge
Anti-angiogenesis therapy is an established therapeutic strategy for cancer. The endogenous angiogenic inhibitor angiostatin contains the first 3-4 kringle domains of plasminogen and inhibits both angiogenesis and vascular permeability. We present here a 10-residue peptide, Angio-3, derived from plasminogen kringle 3, which retains the functions of angiostatin in inhibiting both angiogenesis and vascular permeability. NMR studies indicate that Angio-3 holds a solution structure similar to the corresponding region of kringle 3...
April 24, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29691399/a-serum-microrna-signature-predicts-trastuzumab-benefit-in-her2-positive-metastatic-breast-cancer-patients
#3
Huiping Li, Jiang Liu, Jianing Chen, Huiyun Wang, Linbin Yang, Fei Chen, Siting Fan, Jing Wang, Bin Shao, Dong Yin, Musheng Zeng, Mengfeng Li, Jun Li, Fengxi Su, Qiang Liu, Herui Yao, Shicheng Su, Erwei Song
Trastuzumab is a standard treatment for HER2-positive (HER2+ ) breast cancer, but some patients are refractory to the therapy. MicroRNAs (miRNAs) have been used to predict therapeutic effects for various cancers, but whether miRNAs can serve as biomarkers for HER2+ metastatic breast cancer (MBC) patients remains unclear. Using miRNA microarray, we identify 13 differentially expressed miRNAs in the serum of HER2+ MBC patients with distinct response to trastuzumab, and four miRNAs are selected to construct a signature to predict survival using LASSO model...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29691196/clinical-characteristics-and-outcomes-of-older-women-with-breast-cancer-in-mexico
#4
Paula Cabrera-Galeana, Enrique Soto-Perez-de-Celis, Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, Claudia Arce-Salinas, Juan Matus-Santos, María Teresa Ramírez-Ugalde, Alberto Alvarado-Miranda, Abelardo Meneses-García, Fernando Lara-Medina, Juan Torres-Dominguez, Enrique Bargalló-Rocha, Alejandro Mohar
INTRODUCTION: Although the epidemiology of breast cancer in older women has been widely described before, little is known about the clinical characteristics and prognosis of older patients living in developing countries. Here, we studied older women with breast cancer treated at a public cancer center in Mexico City, and compared their outcomes with their younger counterparts. MATERIALS AND METHODS: We retrospectively analyzed a database of 5488 women treated for breast cancer at a single institution...
April 21, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29690864/radiogenic-angiosarcoma-of-the-breast-case-report-and-systematic-review-of-the-literature
#5
Askin Dogan, Peter Kern, Beate Schultheis, Günther Häusler, Günther A Rezniczek, Clemens B Tempfer
BACKGROUND: Radiogenic angiosarcoma of the breast (RASB) is a rare late sequela of local irradiation of the breast or chest wall after breast cancer. The prognosis of women with RASB is poor and there is no standardized therapy for this type of malignancy. CASE PRESENTATION: We present the case of a 54 year old woman with RASB (poorly differentiated angiosarcoma of the left breast; pT1, pNX, M0, L0, V0) and a history of invasive-ductal cancer of the left breast (pT1b, G2, pN0, ER positive, PR positive, HER-2/neu negative) treated in July 2012 with breast-conserving surgery, adjuvant chemotherapy with 6 cycles of epirubicin and cyclophosphamide, adjuvant irradiation of the left breast with 50 Gray, and adjuvant endocrine therapy with an aromatase inhibitor...
April 24, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29690812/analysis-of-orthopedic-surgery-of-patients-with-metastatic-bone-tumors-and-pathological-fractures
#6
Resit Sevimli, Mehmet Fatih Korkmaz
Objective This study was performed to determine the most common causes, locations, and treatments of metastasizing primary tumors through evaluation of patients with metastatic bone tumors who were admitted to our clinic. Methods In total, 96 patients with metastatic bone tumors who were admitted to our clinic from 2000 to 2016 were included in the study. Results The breast (30 patients, 31.3%) and lung (18 patients, 18.8%) were the most commonly metastasized primary organs. The femur was the most commonly metastasized bone...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29690797/atezolizumab-for-the-treatment-of-breast-cancer
#7
Debora Basile, Giacomo Pelizzari, Maria Grazia Vitale, Camilla Lisanti, Marika Cinausero, Donatella Iacono, Fabio Puglisi
Breast cancer (BC) is the most common cancer diagnosed among women. The development of new personalized therapeutic strategies has reshaped the landscape in this field. However, BC is still the first cause of death among women. Interestingly, several preclinical studies and some clinical evidences are focused their attention on the role of immune system and immunotherapy on cancer control, also in BC. Areas covered: Usually, BC has been considered a not immunogenic tumor for its low mutational load. However, recent studies have evidenced that some subtypes, triple negative and HER-2 positive BC, are "hot" tumors, thus more immunogenic...
April 24, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29689710/esr1-and-pik3ca-mutational-status-in-serum-and-plasma-from-metastatic-breast-cancer-patients-a-comparative-study
#8
Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Mai Tomiguchi, Aiko Sueta, Hirotaka Iwase
PURPOSE: Plasma and serum cell-free DNA (cfDNA) are useful sources of tumor DNA, but comparative investigations of the tumor mutational status between them are rare. METHODS: we performed droplet digital PCR assay for representative hotspot mutations in metastatic breast cancer (MBC) (ESR1 and PIK3CA) in serum and plasma cfDNA concurrently extracted from the blood of 33 estrogen receptor-positive MBC patients. RESULTS: ESR1 mutations in plasma cfDNA were found in 7 of the 33 patients; ESR1 mutations in serum cfDNA were detected in only one out of 7 patients with ESR1 mutations in plasma cfDNA...
April 7, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29689598/correlation-between-circulating-cell-free-pik3ca-tumor-dna-levels-and-treatment-response-in-patients-with-pik3ca-mutated-metastatic-breast-cancer
#9
Annette R Kodahl, Sidse Ehmsen, Niels Pallisgaard, Anne Marie B Jylling, Jeanette Dupont Jensen, Anne-Vibeke Laenkholm, Ann S Knoop, Henrik J Ditzel
Liquid biopsies focusing on the analysis of circulating cell-free tumor DNA (ctDNA) may have important clinical implications for personalized medicine, including early detection of cancer, therapeutic guidance and monitoring of recurrence. Mutations in the oncogene, PIK3CA, are frequently observed in breast cancer and have been suggested as a predictive biomarker for PI3K-selective inhibitor treatment. In this study, we analyzed the presence of PIK3CA mutations in formalin-fixed, paraffin-embedded, metastatic tissue and corresponding ctDNA from serum of patients with advanced breast cancer using a highly-sensitive, optimized droplet digital PCR (ddPCR) assay...
April 24, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29689563/microrna-34a-inhibition-of-the-tlr-signaling-pathway-via-cxcl10-suppresses-breast-cancer-cell-invasion-and-migration
#10
Min Xu, Dong Li, Chen Yang, Jian-Song Ji
BACKGROUND/AIMS: Breast cancer (BC) starts as a local disease, but it can metastasize to the lymph nodes and distant organs. However, the metastatic process is still poorly understood. The mRNA microarray datasets GSE26910 and GSE33447 show that CXCL10 is up-regulated in BC, and the microRNA microarray dataset GSE38167 and a network meta-analysis of microRNA expression profile studies in human BC suggest that microRNA-34a (miR-34a) is down-regulated in BC. CXCL10 was predicted as a target of miR-34a by microRNA...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29689288/self-assembled-amphiphilic-zein-lactoferrin-micelles-for-tumor-targeted-co-delivery-of-rapamycin-and-wogonin-to-breast-cancer
#11
Sally A Sabra, Ahmed O Elzoghby, Salah A Sheweita, Medhat Haroun, Maged W Helmy, Maha A Eldemellawy, Ying Xia, David Goodale, Alison L Allan, Sohrab Rohani
Protein-based micelles have shown significant potential for tumor-targeted delivery of anti-cancer drugs. In this light, self-assembled nanocarriers based on GRAS (Generally recognized as safe) amphiphilic protein co-polymers were synthesized via carbodiimide coupling reaction. The new nano-platform is composed of the following key components: i) hydrophobic zein core to encapsulate the hydrophobic drugs rapamycin (RAP) and wogonin (WOG) with high encapsulation efficiency, ii) hydrophilic lactoferrin (Lf) corona to enhance the tumor targeting, and prolong systemic circulation of the nanocarriers, and iii) glutaraldehyde (GLA)-crosslinking to reduce the particle size and improve micellar stability...
April 21, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29689276/withaferin-a-and-sulforaphane-regulate-breast-cancer-cell-cycle-progression-through-epigenetic-mechanisms
#12
Kendra J Royston, Bidisha Paul, Susan Nozell, Rajani Rajbhandari, Trygve O Tollefsbol
Little is known about the effects of combinatorial dietary compounds on the regulation of epigenetic mechanisms involved in breast cancer prevention. The human diet consists of a multitude of components, and there is a need to elucidate how certain compounds interact in collaboration. Withaferin A (WA), found in the Indian winter cherry and documented as a DNA methyltransferase (DNMT) inhibitor, and sulforaphane (SFN), a well-known histone deacetylase (HDAC) inhibitor found in cruciferous vegetables, are two epigenetic modifying compounds that have only recently been studied in conjunction...
April 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29689246/il-13-is-produced-by-tumor-cells-in-breast-implant-associated-anaplastic-large-cell-lymphoma-implications-for-pathogenesis
#13
Marshall E Kadin, John Morgan, Haiying Xu, Alan L Epstein, David Sieber, Bradley A Hubbard, William P Adams, Carlos E Bacchi, Joao C S Goes, Mark W Clemens, L Jeffrey Medeiros, Roberto N Miranda
More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause and effect relationship, and designated as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogene JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL...
April 21, 2018: Human Pathology
https://www.readbyqxmd.com/read/29689158/synergistically-enhancing-therapeutic-effect-of-radiation-therapy-with-radiation-activatable-and-reactive-oxygen-species-releasing-nanostructures
#14
Kai Cheng, Michael Sano, Cesare H Jenkins, Guanglei Zhang, Don Vernekohl, Wei Zhao, Chenxi Wei, Yan Zhang, Zhe Zhang, Yijin Liu, Zhen Cheng, Lei Xing
Nanoparticle-based radio-sensitizers can amplify the effects of radiation therapy on tumor tissue even at relatively low concentrations while reducing the potential side effects to healthy surrounding tissues. In this study, we investigated a hybrid anisotropic nanostructure, composed of gold (Au) and titanium dioxide (TiO2), as a radio-sensitizer for radiation therapy of triple negative breast cancer (TNBC). In contrast to other gold based radio sensitizers, dumbbell-like Au-TiO2 nanoparticles (DATs) show a synergistic therapeutic effect on radiation therapy, mainly because of strong asymmetric electric coupling between the high atomic number metals and dielectric oxides at their interfaces...
April 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29688063/evaluation-of-a-novel-biocompatible-magnetic-nanomedicine-based-on-beta-cyclodextrin-loaded-doxorubicin-curcumin-for-overcoming-chemoresistance-in-breast-cancer
#15
Roghayeh Rastegar, Hamid Akbari Javar, Mehdi Khoobi, Poua Dehghan Kelishadi, Gholam Hossein Yousefi, Mahmoud Doosti, Mohammad Hossien Ghahremani, Ahmad Sharif Tabrizi, Fatemeh Imanparast, Elham Gholibeglu, Mahdi Gholami
Codelivery of chemo-sensitizers with chemotherapeutics using combo nanomedicine is a promising platform for overcoming chemoresistance in breast cancer. However, tumor accumulation of nano-carriers based on enhanced permeability and retention (EPR) effect is confounded by heterogeneity in tumor microenvironment. Adsorption of protein corona on surface of nanoparticle boost up clearance by reticulo-endothelial system. In this study, a surface functionalized magnetic nanocomposite (NC) for codelivery of doxorubicin (DOX) and curcumin (CUR) is developed...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29687853/lncrna-linc01116-competes-with-mir-145-for-the-regulation-of-esr1-expression-in-breast-cancer
#16
H-B Hu, Q Chen, S-Q Ding
OBJECTIVE: To investigate the biological role and clinical significance of long non-coding RNAs (lncRNA) LINC01116 in breast cancer. MATERIALS AND METHODS: In the public database Gene Expression Omnibus (GEO), the breast cancer data set GSE54002 was screened for differentially expressed lncRNA LINC01116 in breast cancer tissues and paracancerous tissues. Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of LINC01116 in 64 breast cancer tissues and 30 normal breast tissues...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687544/palpable-breast-abnormalities-in-women-under-age-40
#17
Michelle V Lee, Hillary L Shaw, Tingying Chi, Hilary A Brazeal, Susan O Holley, Catherine M Appleton
Although the prevalence of malignancy in average risk women under age 40 presenting with a palpable breast abnormality is low, the management of benign-appearing palpable abnormalities remains controversial. This study assesses the imaging evaluation, subsequent management, and outcomes of women under age 40 presenting with a palpable area of concern. This study also evaluates the costs, utility, and outcomes of BI-RADS 3 assessment in this patient population. A single institution retrospective case review from July 2010 through June 2013 identified women under age 40 presenting with a new palpable breast abnormality...
April 24, 2018: Breast Journal
https://www.readbyqxmd.com/read/29687541/evaluation-of-recurrence-patterns-and-survival-in-modern-series-of-young-women-with-breast-cancer
#18
Kelsey E Larson, Stephen R Grobmyer, Stephanie A Valente
The data on oncologic outcomes in young women with breast cancer (BC) are dated as it relates to recurrences and mortality. Our goal was to assess these outcomes in a modern series of young women with BC. A retrospective chart review identified women ≤40 years old with stage I-III BC diagnosed from 2006 to 2013 at our institution. Demographics, tumor biology, type of operation, recurrence, and survival were analyzed. Overall, 322 women were identified. Most had ER+(70%) infiltrating ductal tumors (88%) with low stage (42% T1; 41% T2; 56% N0)...
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29687533/squamous-differentiation-in-breast-carcinoma-following-neo-adjuvant-chemotherapy-therapy-effect-vs-tumor-heterogeneity
#19
Pallavi A Patil, Kamaljeet Singh, Cherie Paquette, M Ruhul Quddus
No abstract text is available yet for this article.
April 23, 2018: Breast Journal
https://www.readbyqxmd.com/read/29687293/psychosocial-stress-exposure-disrupts-mammary-gland-development
#20
Marianna B Johnson, Joscelyn N Hoffmann, Hannah M You, Ricardo R Lastra, Sully Fernandez, Jordan W Strober, Ahmad B Allaw, Matthew J Brady, Suzanne D Conzen, Martha K McClintock
Exposure to psychosocial stressors and ensuing stress physiology have been associated with spontaneous invasive mammary tumors in the Sprague-Dawley rat model of human breast cancer. Mammary gland (MG) development is a time when physiologic and environmental exposures influence breast cancer risk. However, the effect of psychosocial stress exposure on MG development remains unknown. Here, in the first comprehensive longitudinal study of MG development in nulliparous female rats (from puberty through young adulthood; 8-25 wks of age), we quantify the spatial gradient of differentiation within the MG of socially stressed (isolated) and control (grouped) rats...
April 23, 2018: Journal of Mammary Gland Biology and Neoplasia
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