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https://www.readbyqxmd.com/read/27916488/human-organic-anion-transporter-2-is-an-entecavir-but-not-tenofovir-transporter
#1
Tomomi Furihata, Hanae Morio, Meiyan Zhu, Yuki Suzuki, Hideyuki Ide, Akihito Tsubota, Zhongguo Fu, Naohiko Anzai, Kan Chiba
Entecavir (ETV) and tenofovir (TFV) are essential nucleoside analogues in current hepatitis B virus (HBV) treatments. Since these drugs target the HBV polymerase that is localized within human hepatocytes, determining of their cellular uptake process is an important step in fully understanding their pharmacological actions. However, the human hepatic transporters responsible for their uptake have remained unidentified. Therefore, this study aimed at identifying the primary ETV and TFV uptake transporter(s) in human hepatocytes...
September 23, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27915131/the-efficacy-and-safety-comparison-between-tenofovir-and-entecavir-in-treatment-of-chronic-hepatitis-b-and-hbv-related-cirrhosis-a-systematic-review-and-meta-analysis
#2
Ying Han, Ajuan Zeng, Huiyu Liao, Yanmin Liu, Yuhan Chen, Huiguo Ding
BACKGROUND: The purpose of this study was to assess the efficacy and safety between tenofovir and entecavir in the treatment of CHB and HBV related cirrhosis through Meta-analysis. Methods The electronic databases of PubMed, the Cochrane Library, Nature, CNKI and WanFang data were searched. The key words were: ("tenofovir", "entecavir") and ("Chronic Hepatitis B" or "CHB") and "Liver cirrhosis". Heterogeneity and report bias were analyzed. RESULTS: There was significant difference of ALT norm level in the short-term period of 3months (RR=1...
December 1, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27911926/international-collaboration-patterns-and-effecting-factors-of-emerging-technologies
#3
Xu Bai, Yun Liu
With the globalization of the world economy, international innovation collaboration has taken place all over the world. This study selects three emerging technologies (3D printing, big data and carbon nanotubes and graphene technology) among 20 countries as the research objects, using three patent-based indicators and network relationship analysis to reflect international collaboration patterns. Then we integrate empirical analyses to show effecting factors of international collaboration degrees by using panel data...
2016: PloS One
https://www.readbyqxmd.com/read/27866195/comparison-of-telbivudine-and-entecavir-therapy-on-nephritic-function-and-drug-resistance-in-patients-with-hepatitis-b-virus-related-compensated-cirrhosis
#4
Huajiang Shen, Feng Ding, Zhiwei Wang, Fang Sun, Yafeng Yu, Jiankang Zhou, Wenfang Xu, Jianchao Ni, Jiangang Wang, Yida Yang
BACKGROUND: To compare the impact of telbivudine (LDT) and entecavir (ETV) administration on nephritic function. METHOD: One hundred thirty patients diagnosed with hepatitis B virus (HBV)-related compensated cirrhosis were randomly divided into LDT (600 mg/d) or ETV (0.5 mg/d) groups. RESULTS: The drug resistance rate was higher following LDT treatment compared to ETV treatment (16.9% vs. 1.5%, P=0.0006). The mean creatinine level decreased compared to baseline in the LDT group (0...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27862721/efficacy-and-safety-of-tenofovir-disoproxil-fumarate-rescue-therapy-for-chronic-hepatitis-b-patients-who-failed-other-nucleos-t-ide-analogues
#5
Hiromitsu Kumada, Kazuhiko Koike, Kazuaki Suyama, Hiroshi Ito, Hiroshi Itoh, Wataru Sugiura
OBJECTIVE: Acquisition of nucleos(t)ide analogue (NA) inhibitors resistance is critical in successful chronic hepatitis B treatment. As the pattern of tenofovir disoproxil fumarate (TDF) resistance mutations differs from that of other antiviral drugs, we sought to clarify the salvaging potential of TDF in HBV patients who are poor responders or resistant to other NAs. MATERIALS AND METHOD: A prospective, multi-center, one-arm, open-label study was conducted from December 2011 to October 2014...
November 15, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27858892/circulating-kidney-injury-molecule-1-is-a-novel-diagnostic-biomarker-for-renal-dysfunction-during-long-term-adefovir-therapy-in-chronic-hepatitis-b
#6
Ziyue Li, Chuan Shen, Yadong Wang, Wei Wang, Qian Zhao, Zhenzhong Liu, Yang Wang, Caiyan Zhao
The aim of this study was to evaluate serum kidney injury molecule-1 (KIM-1) as a new diagnostic marker of renal dysfunction in chronic hepatitis B (CHB) patients receiving long-term adefovir dipivoxil (ADV) treatment.We retrospectively enrolled 85 patients treated with ADV and 85 patients treated with entecavir (ETV) monotherapy, for at least 6 months. The 2 groups were matched for baseline age (± 5 years), sex, and estimated glomerular filtration rate (eGFR). Serum creatinine, cystatin C, and KIM-1 concentrations were measured, and eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation, at baseline and last follow-up...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858385/third-ventricle-floor-variations-and-abnormalities-in-myelomeningocele-associated-hydrocephalus-an-experience-in-455-endoscopic-third-ventriculostomy-procedures
#7
Volkan Etus, Tugba Morali Guler, Hakan Karabagli
AIM: This multicenter study aims to evaluate the incidence of anatomical variations and abnormalities of the third ventricle floor encountered during endoscopic third ventriculostomy (ETV) procedure in myelomeningocele associated hydrocephalus (MAH) cases. MATERIAL AND METHODS: A retrospective analysis was performed on 455 pediatric MAH cases that have been treated with ETV. This case series consisted of the patients who were initially treated with ETV and those who were treated with ETV for the management of cerebrospinal fluid shunt dysfunction as well...
September 21, 2016: Turkish Neurosurgery
https://www.readbyqxmd.com/read/27847098/lamivudine-switch-therapy-in-chronic-hepatitis-b-patients-achieving-undetectable-hepatitis-b-virus-dna-after-3-years-of-entecavir-therapy-a-prospective-open-label-multicenter-study
#8
Ming-Lun Yeh, Ching-I Huang, Ming-Yen Hsieh, Chung-Feng Huang, Meng-Hsuan Hsieh, Jee-Fu Huang, Chia-Yen Dai, Zu-Yau Lin, Shinn-Chern Chen, Ming-Lung Yu, Wan-Long Chuang
The subsequent maintenance therapy in chronic hepatitis B (CHB) patients after long-term viral replication suppression is still uncertain. We aim to evaluate the efficacy of lamivudine (LAM) maintenance therapy in CHB patients achieving undetectable hepatitis B virus (HBV) DNA after 3 years of entecavir (ETV) therapy. Consecutive CHB patients who received at least 3 years of ETV and achieved HBV DNA negativity were allocated either LAM switch therapy or stopped ETV therapy in a prospective, open-label study...
November 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27845395/slow-reduction-of-ip-10-levels-predicts-hbeag-seroconversion-in-chronic-hepatitis-b-patients-with-5-years-of-entecavir-treatment
#9
Renyong Guo, Hejun Mao, Xiao Hu, Nengneng Zheng, Dong Yan, Jianqin He, Jiezuan Yang
The aim of this study was to determine the correlation between dynamic changes in serum cytokine/chemokine expression levels in response to entecavir (ETV) treatment and HBV e antigen (HBeAg) seroconversion in patients with chronic hepatitis B (CHB). Four cytokines (interleukin [IL]-4, IL-6, IL-8, and interferon-γ) and five chemokines (macro-phage inflammatory protein [MIP]-1α, MIP-1β, platelet derived growth factor-BB, and interferon-inducible protein 10 [IP-10]) before ETV therapy and at 3, 6, 12, 24, 36 and 60 months during therapy in 105 CHB patients were analyzed...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822262/a-cost-utility-and-cost-effectiveness-analysis-of-different-oral-antiviral-medications-in-patients-with-hbeag-negative-chronic-hepatitis-b-in-iran-an-economic-microsimulation-decision-model
#10
Khosro Keshavarz, Abbas Kebriaeezadeh, Seyed Moayed Alavian, Ali Akbari Sari, Mohsen Rezaei Hemami, Farhad Lotfi, Amir Hashemi Meshkini, Mehdi Javanbakht, Maryam Keshvari, Shekoufeh Nikfar
BACKGROUND: Although hepatitis B infection is the major cause of chronic liver disease in Iran, no studies have employed economic evaluations of the medications used to treat Iranian patients with chronic hepatitis B (CHB). Therefore, the cost-effectiveness of the different treatment options for this disease in Iran is unknown. OBJECTIVES: The aim of this study was to compare the cost utility and cost-effectiveness of medication strategies tailored to local conditions in patients with HB e antigen (HBeAg)-negative CHB infection in Iran...
September 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/27807671/surgical-treatment-of-long-standing-overt-ventriculomegaly-in-adults-lova
#11
Ronak Ved, Paul Leach, Chirag Patel
BACKGROUND: Longstanding overt ventriculomegaly in adults (LOVA) is characterised by chronic hydrocephalus presumed to begin during infancy, but arresting before becoming clinically detectable. Later in life clinical features of hydrocephalus ensue, typically in the 5th or 6th decades. Only a relatively small number of LOVA case series have been published, and ambiguity remains regarding optimal management. This case series describes a series of patients with LOVA treated successfully at a single neurosurgical institution using endoscopic third ventriculostomy (ETV)...
November 2, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27796553/cerebrospinal-fluid-csf-shunting-and-ventriculocisternostomy-etv-in-400-pediatric-patients-shifts-in-understanding-diagnostics-case-mix-and-surgical-management-during-half-a-century
#12
A Henriette Paulsen, Bernt J Due-Tønnessen, Tryggve Lundar, Karl-Fredrik Lindegaard
OBJECTIVE: To characterize shifts from the 1960s to the first decade in the 21st century as to diagnostics, case-mix, and surgical management of pediatric patients undergoing permanent CSF diversion procedures. METHODS: One hundred and thirty-four patients below 15 years of age were the first time treated with CSF shunt or ETV for hydrocephalus or idiopathic intracranial hypertension (IIH) in 2009-2013. This represents our current practice. Our previously reported cohorts of shunted children 1967-1970 (n = 128) and 1985-1988 (n = 138) served as backgrounds for comparison...
October 29, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27792585/comparison-of-detection-rate-and-mutational-pattern-of-drug-resistant-mutations-between-a-large-cohort-of-genotype-b-and-genotype-c-hepatitis-b-virus-infected-patients-in-north-china
#13
Xiaodong Li, Yan Liu, Shaojie Xin, Dong Ji, Shaoli You, Jinhua Hu, Jun Zhao, Jingjing Wu, Hao Liao, Xin-Xin Zhang, Dongping Xu
The study aimed to investigate the association of prevalent genotypes in China (HBV/C and HBV/B) with HBV drug-resistant mutations. A total of 13,847 nucleos(t)ide analogue (NA)-treated patients with chronic HBV infection from North China were enrolled. HBV genotypes and resistant mutations were determined by direct sequencing and confirmed by clonal sequencing if necessary. HBV/B, HBV/C, and HBV/D occupied 14.3%, 84.9%, and 0.8% across the study population, respectively. NA usage had no significant difference between HBV/B- and HBV/C-infected patients...
October 28, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27777855/telbivudine-for-the-treatment-of-chronic-hepatitis-b-in-hbeag-positive-patients-in-china-a-health-economic-analysis
#14
S Banerjee, P Gunda, R F Drake, K Hamed
BACKGROUND: Nucleos(t)ide analogs (NUCs) are the standard of care for chronic hepatitis B (CHB). The present analysis aimed to determine the cost effectiveness of NUCs in Chinese healthcare settings. METHODS: A Markov model was used to simulate two therapeutic strategies for a hypothetical patient cohort diagnosed with hepatitis B e antigen-positive CHB, unwilling or unable to receive interferon therapy, and about to start treatment with any NUC. The first strategy included NUC monotherapy without sequencing (telbivudine [LDT], entecavir [ETV], tenofovir [TDF], lamivudine [LAM], adefovir dipivoxil [ADV], and combination therapies of either LDT and ADV or LDT and TDF, followed by best supportive care [BSC])...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27774823/endoscopic-third-ventriculostomy-a-historical-review
#15
Amin Demerdash, Brandon G Rocque, James Johnston, Curtis J Rozzelle, Bulent Yalcin, Rod Oskouian, Johnny Delashaw, R Shane Tubbs
BACKGROUND: Endoscopic third ventriculostomy (ETV) has become one of the most common neuroendoscopic procedures. METHODS: In this article, we will review the major milestones in the history of ETV development from its early use by Walter Dandy to the techniques currently employed with advanced technology. CONCLUSIONS: ETV has become an important technique in the armamentarium of the neurosurgeon. From a meager beginning with few applications, our knowledge of long-term outcomes has evolved...
October 22, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27766731/tenofovir-versus-tenofovir-plus-entecavir-for-chronic-hepatitis-b-with-lamivudine-resistance-and-entecavir-resistance
#16
S Lee, S H Ahn, K S Jung, D Y Kim, B K Kim, S U Kim, O Baatarkhuu, H J Ku, K Han, J Y Park
We compared the viral suppressive efficacy of tenofovir disoproxil fumarate (TDF) mono-rescue therapy (TDF group) and TDF plus entecavir (ETV) combination-rescue therapy (TDF + ETV group) in chronic hepatitis B (CHB) patients with lamivudine resistance and entecavir resistance. One hundred and thirty-three CHB patients with lamivudine and entecavir resistance were investigated. Ninety-six patients were treated with TDF and 37 with TDF + ETV for at least 6 months. We compared the virologic response rate (HBV DNA level <20 IU/mL) between the two groups and identified the predictive factors of treatment outcome...
October 20, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27766627/whole-body-magnetic-resonance-imaging-in-newly-diagnosed-multiple-myeloma-early-changes-in-lesional-signal-fat-fraction-predict-disease-response
#17
Arash Latifoltojar, Margaret Hall-Craggs, Neil Rabin, Rakesh Popat, Alan Bainbridge, Nikolaos Dikaios, Magdalena Sokolska, Ali Rismani, Shirley D'Sa, Shonit Punwani, Kwee Yong
Cross-sectional imaging techniques are being increasingly used for disease evaluation in patients with multiple myeloma. Whole body magnetic resonance imaging (WB-MRI) scanning is superior to plain radiography in baseline assessment of patients but changes following treatment have not been systematically explored. We carried out paired WB-MRI scans in 21 newly diagnosed patients prior to, and 8-weeks after, starting chemotherapy, and analysed stringently selected focal lesions (FLs) for parametric changes. A total of 323 FLs were evaluated, median 20 per patient...
October 21, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27761438/treatment-for-hepatitis-b-in-patients-with-drug-resistance
#18
Frank Tacke, Daniela C Kroy
Persistent hepatitis B virus (HBV) infections affect about 240 million patients worldwide that are at risk of developing liver cirrhosis or hepatocellular carcinoma. HBV is a small, partially double stranded DNA virus with four overlapping genes and a unique life cycle, which involves the generation of an RNA template for replication via reverse transcription. Mutations occur frequently during chronic infection, and particular selection pressures select distinct mutants. Nucleoside and nucleotide analogues like lamivudine (LMV), entecavir (ETV), telbivudine (LdT), adefovir dipivoxil (ADV) and tenofovir (TDF) are used to achieve long-term suppression of viral replication...
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27757566/tectal-glioma-presenting-with-clinical-triad-of-obesity-amenorrhea-and-central-cord-syndrome-with-radiological-pentad-of-hydrocephalus-empty-sella-suprapineal-diverticula-chiari-and-syrinx
#19
Sivashanmugam Dhandapani, Madhivanan Karthigeyan, Sushanta K Sahoo, Vivek Gupta
BACKGROUND: Tectal gliomas (TG) are slow-growing tumors and generally present with features of increased intracranial pressure. CASE DESCRIPTION: We describe an unusual case of a young girl who presented with clinical triad of obesity, primary amenorrhea and central cord syndrome. The radiology unveiled a pentad of hydrocephalus, empty sella, suprapineal recess diverticulum, secondary Chiari malformation and cervical syringomyelia, masking a relatively obscure tectal plate glioma...
October 18, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27750153/discovery-of-novel-piperidine-substituted-indolylarylsulfones-as-potent-hiv-nnrtis-via-structure-guided-scaffold-morphing-and-fragment-rearrangement
#20
Xiao Li, Ping Gao, Boshi Huang, Zhongxia Zhou, Zhao Yu, Zheng Yuan, Huiqing Liu, Christophe Pannecouque, Dirk Daelemans, Erik De Clercq, Peng Zhan, Xinyong Liu
To further explore the chemical space around the entrance channel of HIV-1 reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing N-substituted piperidine at indole-2-carboxamide were identified as potent HIV NNRTIs by structure-guided scaffold morphing and fragment rearrangement. All the IASs exhibited moderate to excellent potency against wild-type HIV-1 with EC50 values ranging from 0.62 μM to 0.006 μM 8 (EC50 = 6 nM) and 18 (EC50 = 9 nM) were identified as the most potent compounds, which were more active than NVP and DLV, and reached the same order of EFV and ETV...
October 5, 2016: European Journal of Medicinal Chemistry
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