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Depression and dementia

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https://www.readbyqxmd.com/read/29792244/affective-problems-and-decline-in-cognitive-state-in-older-adults-a-systematic-review-and-meta-analysis
#1
A John, U Patel, J Rusted, M Richards, D Gaysina
Evidence suggests that affective problems, such as depression and anxiety, increase risk for late-life dementia. However, the extent to which affective problems influence cognitive decline, even many years prior to clinical diagnosis of dementia, is not clear. The present study systematically reviews and synthesises the evidence for the association between affective problems and decline in cognitive state (i.e., decline in non-specific cognitive function) in older adults. An electronic search of PubMed, PsycInfo, Cochrane, and ScienceDirect was conducted to identify studies of the association between depression and anxiety separately and decline in cognitive state...
May 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29792064/the-effect-and-importance-of-physical-activity-on-behavioural-and-psychological-symptoms-in-people-with-dementia-a-systematic-mixed-studies-review
#2
Tina Junge, Jonas Ahler, Hans K Knudsen, Hanne K Kristensen
Background People with dementia may benefit from the effect of physical activity on behavioural and psychological symptoms of dementia. Qualitative synthesis of the importance of physical activity might complement and help clarify quantitative findings on this topic. The purpose of this systematic mixed studies review was to evaluate findings from both quantitative and qualitative methods about the effect and importance of physical activity on behavioural and psychological symptoms of dementia in people with dementia...
January 1, 2018: Dementia
https://www.readbyqxmd.com/read/29791025/factors-associated-with-quality-of-life-of-dementia-caregivers-direct-and-indirect-effects
#3
Hikaru Oba, Teruyuki Matsuoka, Yuka Kato, Jin Narumoto
AIMS: To examine the direct and indirect relationships between the characteristics of patients and caregivers associated with caregivers' quality of life. BACKGROUND: Complex relationships exist among the factors associated with caregivers' quality of life. DESIGN: This study was a retrospective cross-sectional design. METHODS: The data were retrospectively extracted from participants who had visited the Center for Diagnosis of Dementia at Kyoto Prefectural University of Medicine from April 2013 - March 2016...
May 23, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29790690/validation-of-the-portuguese-version-of-addenbrooke-s-cognitive-examination-iii-in-mild-cognitive-impairment-and-dementia
#4
Bruno Peixoto, Milene Machado, Patricia Rocha, Carla Macedo, António Machado, Élia Baeta, Gerly Gonçalves, Paulo Pimentel, Emanuela Lopes, Luis Monteiro
BACKGROUND: Cognitive assessment is central to the diagnosis of cognitive impairment and dementia, and it should be performed in all patients in the early stages of the disease. Recently, the 3rd version of Addenbrooke's Cognitive Examination (ACE-III) has been developed in order to improve the previous versions. OBJECTIVES: The aim of this study was to determine the psychometric properties of the Portuguese version of ACE-III, namely: reliability and discriminative validity (sensitivity and specificity) in the identification of mild cognitive impairment (MCI) and dementia, in comparison to other neuropsychological screening tests, as well as to establish its concurrent and divergent validity...
May 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29789032/neuropsychological-correlates-of-instrumental-activities-of-daily-living-in-neurocognitive-disorders-a-possible-role-for-executive-dysfunction-and-mood-changes
#5
Martina Amanzio, Sara Palermo, Milena Zucca, Rosalba Rosato, Elisa Rubino, Daniela Leotta, Massimo Bartoli, Innocenzo Rainero
ABSTRACTSince baseline executive dysfunction predicts worsening Instrumental Activities of Daily Living (i-ADL) over time and progression to Alzheimer's Disease (AD), we aimed to analyze the role of neuropsychological variables to outline which factors can contribute to functional impairment. Specific attention to executive functions (EFs) has been given.A total of 144 subjects complaining of different cognitive deficits - ranging from "MCI likely due to AD" to "mild AD patients" - underwent an overall neuropsychological assessment...
May 23, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29787954/the-effectiveness-of-a-cognitive-training-program-in-people-with-mild-cognitive-impairment-a-study-in-urban-community
#6
Chalermpong Sukontapol, Sasithorn Kemsen, Sirintorn Chansirikarn, Daochompu Nakawiro, Orawan Kuha, Unchulee Taemeeyapradit
OBJECTIVE: To assess the effectiveness of a cognitive training program on global cognition among people with mild cognitive impairment. METHODS: In this experimental study, using purposive sampling, 60 participants age 50 years and over who complained of subjective memory impairment were screened in their communities by public health volunteers with the Abbreviated Mental Test. Those with dementia were excluded as well as those with depression, which were screened out by the Thai Geriatric Depression Scale (TGDS-15)...
May 19, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29786922/finding-factors-that-predict-treatment-resistant-depression-results-of-a-cohort-study
#7
M Soledad Cepeda, Jenna Reps, Patrick Ryan
BACKGROUND: Treatment for depressive disorders often requires subsequent interventions. Patients who do not respond to antidepressants have treatment-resistant depression (TRD). Predicting who will develop TRD may help healthcare providers make more effective treatment decisions. We sought to identify factors that predict TRD in a real-world setting using claims databases. METHODS: A retrospective cohort study was conducted in a US claims database of adult subjects with newly diagnosed and treated depression with no mania, dementia, and psychosis...
May 22, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29785803/depressive-spectrum-states-in-a-population-based-cohort-of-70-year-olds-followed-over-9-years
#8
Robert Sigström, Margda Waern, Pia Gudmundsson, Ingmar Skoog, Svante Östling
OBJECTIVE: Depression may be understood as a spectrum of more or less symptomatic states. Little is known about the long-term course of these states in older populations. We examined the prevalence and course of depressive states of different severity in a Swedish population sample of older people followed over 9 years. METHODS: A population-based sample of 70-year olds without dementia (N = 563, response rate 71.1%) underwent a psychiatric examination; 450 survivors without dementia were reexamined at ages 75 and/or 79 years...
May 21, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29785782/path-analysis-of-caregiver-characteristics-and-neuropsychiatric-symptoms-in-alzheimer-s-disease-patients
#9
Lais L Delfino, Ricardo S Komatsu, Caroline Komatsu, Anita L Neri, Meire Cachioni
AIM: To determine the direct and indirect relationships of sociodemographic, emotional and behavioral characteristics of family caregivers of Alzheimer's disease patients who have neuropsychiatric symptoms. METHODS: A total of 134 family caregivers answered a questionnaire with sociodemographic data, and questions regarding the context of care, Neuropsychiatric Inventory, Zarit Burden Interview, Dementia Management Strategies Scale and the Beck Depression Inventory...
May 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29784047/memory-related-subjective-cognitive-symptoms-in-the-adult-population-prevalence-and-associated-factors-results-of-the-life-adult-study
#10
Tobias Luck, Susanne Roehr, Francisca S Rodriguez, Matthias L Schroeter, A Veronica Witte, Andreas Hinz, Anja Mehnert, Christoph Engel, Markus Loeffler, Joachim Thiery, Arno Villringer, Steffi G Riedel-Heller
BACKGROUND: Subjectively perceived memory problems (memory-related Subjective Cognitive Symptoms/SCS) can be an indicator of a pre-prodromal or prodromal stage of a neurodegenerative disease such as Alzheimer's disease. We therefore sought to provide detailed empirical information on memory-related SCS in the dementia-free adult population including information on prevalence rates, associated factors and others. METHODS: We studied 8834 participants (40-79 years) of the population-based LIFE-Adult-Study...
May 21, 2018: BMC Psychology
https://www.readbyqxmd.com/read/29768974/brain-phospholipid-precursors-administered-post-injury-reduce-tissue-damage-and-improve-neurological-outcome-in-experimental-traumatic-brain-injury
#11
Orli Thau-Zuchman, Rita Noutel Gomes, Simon Christopher Dyall, Meirion Davis, John V Priestley, Martine Groenendijk, Martijn DE Wilde, Jordi Lopez-Tremoleda, Adina T Michael-Titus
Traumatic brain injury (TBI) leads to cellular loss, destabilisation of membranes, disruption of synapses and altered brain connectivity, and increased risk of neurodegenerative disease. A significant and long-lasting decrease in phospholipids (PL), essential membrane constituents, has recently been reported in plasma and brain tissue, in human and experimental TBI. We hypothesised that supporting PL synthesis post-injury could improve outcome after TBI. We tested this hypothesis using a multi-nutrient combination designed to support the biosynthesis of phospholipids and available for clinical use...
May 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29764877/efficacy-of-practising-tai-chi-for-older-people-with-mild-dementia-protocol-for-a-randomised-controlled-study
#12
Jihui Lyu, Wenjie Li, Xiangjiang Rong, Lian Wei, Nayan Huang, Mei Champ, Qian Xiong, Xueli Chen, Mo Li, Fangling Li
INTRODUCTION: Many studies suggest that Tai Chi exercise is a safe and appropriate mind-body exercise for older people and effectively slows down age-related cognitive decline. A set of bespoke Tai Chi exercise named 'Cognition Protecting Tai Chi' (CPT) has been created for older people with cognitive impairments by the research team of geriatricians, neurologists, rehabilitation specialists, experts of sports medicine and experienced practitioners of traditional Chinese medicine. This trial is designed to evaluate its effects on cognitive function, behaviour/moods, risk of falls and activities of daily living of the participants with mild dementia...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29762677/anti-dementia-drugs-for-psychopathology-and-cognitive-impairment-in-schizophrenia-a-systematic-review-and-meta-analysis
#13
Taro Kishi, Toshikazu Ikuta, Kazuto Oya, Shinji Matsunaga, Yuki Matsuda, Nakao Iwata
Background: We conducted a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials of anti-dementia drugs plus antipsychotics (ADD+AP) for schizophrenia. Methods: Primary outcomes of efficacy and safety included improving overall symptoms (Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale scores) and all-cause discontinuation, respectively. Other outcomes included psychopathology subscales (positive, negative, general, and anxiety/depressive symptoms), cognitive function (attention/vigilance, reasoning/problem solving, social cognition, speed of processing, verbal learning, visual learning, working memory, and cognitive control/executive function), Mini-Mental State Examination (MMSE) scores, treatment discontinuation due to adverse events and inefficacy, and individual adverse events...
May 14, 2018: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29762315/effectiveness-of-psychosocial-interventions-on-the-psychological-health-and-emotional-well-being-of-family-carers-of-people-with-dementia-following-residential-care-placement-a-systematic-review
#14
Deborah Brooks, Elaine Fielding, Elizabeth Beattie, Helen Edwards, Sonia Hines
OBJECTIVE: To identify, appraise and synthesize existing evidence regarding the effectiveness of psychosocial interventions on the psychological health and emotional well-being of family carers of people with dementia who have moved into residential care. INTRODUCTION: Many carers experience stress, guilt, grief and depression following placement of a relative with dementia into residential care. Psychosocial interventions to support family carers may help to improve psychological health and emotional well-being; however, evidence for such interventions delivered to family carers following placement has yet to be appraised and synthesized...
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29761589/prevalence-and-effect-factors-of-dementia-among-the-community-elderly-in-chongqing-china
#15
Jing Deng, Cheng Cao, Yi Jiang, Bin Peng, Tingting Wang, Ke Yan, Jingxi Lian, Zengzi Wang
BACKGROUND: China is an ageing society, with around 150 million people aged 60 years or older. The prevalence of dementia will increase by more than 100% in the coming 20 years. This study aimed to investigate the prevalence and effects of dementia among the community elderly in Chongqing, China. METHODS: Cluster sampling was adopted. A sample of elderly individuals aged 60 years and older was extracted as research subjects from three counties within Chongqing, China...
May 14, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29752348/genetic-study-of-white-matter-integrity-in-uk-biobank-n-8448-and-the-overlap-with-stroke-depression-and-dementia
#16
Loes C A Rutten-Jacobs, Daniel J Tozer, Marco Duering, Rainer Malik, Martin Dichgans, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: Structural integrity of the white matter is a marker of cerebral small vessel disease, which is the major cause of vascular dementia and a quarter of all strokes. Genetic studies provide a way to obtain novel insights in the disease mechanism underlying cerebral small vessel disease. The aim was to identify common variants associated with microstructural integrity of the white matter and to elucidate the relationships of white matter structural integrity with stroke, major depressive disorder, and Alzheimer disease...
May 11, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29751506/neurocognitive-disorders-and-dehydration-in-older-patients-clinical-experience-supports-the-hydromolecular-hypothesis-of-dementia
#17
Michele Lauriola, Antonio Mangiacotti, Grazia D'Onofrio, Leandro Cascavilla, Francesco Paris, Giulia Paroni, Davide Seripa, Antonio Greco, Daniele Sancarlo
Abnormalities of water homeostasis can be early expressions of neuronal dysfunction, brain atrophy, chronic cerebrovasculopathy and neurodegenerative disease. The aim of this study was to analyze the serum osmolality of subjects with cognitive impairment. One thousand and ninety-one consecutive patients attending the Alzheimer’s Evaluation Unit were evaluated with the Mini-Mental State Examination (MMSE), 21-Item Hamilton Depression Rating Scale (HDRS-21), Activities of Daily Living (ADL), Instrumental-ADL (IADL), Mini Nutritional Assessment (MNA), Exton-Smith Scale (ESS), and Cumulative Illness Rating Scale (CIRS)...
May 3, 2018: Nutrients
https://www.readbyqxmd.com/read/29751080/prenylated-%C3%AE-diketones-two-new-additions-to-the-family-of-biologically-active-hypericum-perforatum-l-hypericaceae-secondary-metabolites
#18
Niko S Radulović, Marija S Genčić, Nikola M Stojanović, Pavle J Randjelović, Nicolas Baldovini, Vanya Kurteva
Two novel β-diketones, 2,6,9-trimethyl-8-decene-3,5-dione (A) and 3,7,10-trimethyl-9-undecene-4,6-dione (B), were identified from the renowned medicinal plant Hypericum perforatum L. The structures of β-diketones A and B were corroborated by syntheses (4 steps starting from methyl acetoacetate, overall yields 30% and 23%, respectively). In solution, these β-diketones predominantly exist as two rapidly interconverting β-keto-enol tautomers. The structures of A and B show some common fragments with the molecules of hyperforin and adhyperforin, respectively, the acknowledged multi-target secondary metabolites from St...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29747721/longitudinal-changes-in-quality-of-life-among-elderly-people-with-and-without-dementia
#19
A E Ydstebø, S Bergh, G Selbæk, J Šaltytė Benth, K Brønnick, C Vossius
ABSTRACTObjective:To study longitudinal changes in the quality of life (QoL) in persons with and without dementia, and explore the factors associated with baseline QoL and changes of QoL over the follow-up period. DESIGN: Prospective longitudinal study. SETTING: Data were collected from 17 municipalities in Norway in the period from January 2009 to August 2012. A total of 412 persons were included, 254 (61.7 %) persons without dementia and 158 (38.3 %) with dementia at baseline...
May 11, 2018: International Psychogeriatrics
https://www.readbyqxmd.com/read/29747139/prevalence-of-anxiety-in-patients-with-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#20
REVIEW
Chunli Chen, Zhiping Hu, Zheng Jiang, Fangfang Zhou
BACKGROUND: Prevalence rates of anxiety in patients with mild cognitive impairment (MCI) varied widely across studies and may confer a higher likelihood of progression to dementia. Our aim was to estimate the prevalence of anxiety in MCI and identify reasons for heterogeneity in the reported results. METHODS: A computerized search in PubMed, EMBASE, and Psyc INFO for studies on anxiety in MCI was performed up to March 2017. The overall prevalence of anxiety in patients with MCI was pooled using a random-effects model...
April 26, 2018: Journal of Affective Disorders
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