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https://www.readbyqxmd.com/read/28916936/does-diabetes-mellitus-comorbidity-affect-in-hospital-mortality-and-length-of-stay-analysis-of-administrative-data-in-an-italian-academic-hospital
#1
Francesca Valent, Laura Tonutti, Franco Grimaldi
AIMS: Hospitalized patients with comorbid diabetes mellitus may have worse outcomes than the others. We conducted a study to assess whether comorbid diabetes affects in-hospital mortality and length of stay. METHODS: For this population-based study, we analyzed the administrative databases of the Regional Health Information System of the Region Friuli Venezia Giulia, where the Hospital of Udine is located. Hospital discharge data were linked at the individual patient level with the regional Diabetes Mellitus Registry to identify diabetic patients...
September 15, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28916436/treating-overactive-bladder-in-older-patients-with-a-combination-of-mirabegron-and-solifenacin-a-prespecified-analysis-from-the-beside-study
#2
William Gibson, Scott MacDiarmid, Moses Huang, Emad Siddiqui, Matthias Stölzel, Nurul Choudhury, Marcus J Drake
BACKGROUND: The BESIDE study demonstrated that combination therapy (mirabegron and solifenacin 5mg) improved overactive bladder symptoms versus solifenacin 5mg or 10mg, and was well tolerated. OBJECTIVE: To ensure efficacy and safety is maintained in older patients (>65 yr), who usually experience greater symptom severity and comorbidities, a prespecified subanalysis stratified by age group was conducted. DESIGN, SETTING, AND PARTICIPANTS: Patients remaining incontinent (≥1 episode during 3-d diary) following 4-wk single-blind daily solifenacin 5mg were randomized 1:1:1 to a daily double-blind combination (solifenacin 5mg and mirabegron 25mg, increased to 50mg at wk 4), solifenacin 5mg or 10mg for 12 wk...
September 12, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28914707/prospective-randomized-feasibility-study-assessing-the-effect-of-cyclic-sacral-neuromodulation-on-urinary-urge-incontinence-in-women
#3
Steven Siegel, Karl Kreder, Elizabeth Takacs, Rachael McNamara, Fangyu Kan
OBJECTIVES: The aim of this prospective, randomized, multicenter, single-blind, 4 × 4 crossover study was to estimate the effect of 4 InterStim cycling settings (continuous, 16 seconds on/8 seconds off, 10 minutes on/10 minutes off, and 30 minutes on/23.5 hours off) on efficacy, Global Response Assessment, and safety. METHODS: Eligible women implanted for at least 3 months for urgency urinary incontinence (UI) were enrolled, and daily diaries were collected. General linear mixed models were used to estimate the cycling effect on efficacy...
September 13, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28912683/nano-scale-biophysical-and-structural-investigations-on-intact-and-neuropathic-nerve-fibers-by-simultaneous-combination-of-atomic-force-and-confocal-microscopy
#4
Gonzalo Rosso, Ivan Liashkovich, Peter Young, Victor Shahin
The links between neuropathies of the peripheral nervous system (PNS), including Charcot-Marie-Tooth1A and hereditary neuropathy with liability to pressure palsies, and impaired biomechanical and structural integrity of PNS nerves remain poorly understood despite the medical urgency. Here, we present a protocol describing simultaneous structural and biomechanical integrity investigations on isolated nerve fibers, the building blocks of nerves. Nerve fibers are prepared from nerves harvested from wild-type and exemplary PNS neuropathy mouse models...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28910949/-china-hainan-centenarian-cohort-study-study-design-and-preliminary-results
#5
Y He, F X Luan, Y Yao, S S Yang, H G Xie, J Li, M Liu, J H Wang, L Wu, Q Zhu, X P Chen, C X Ning, L N Wang, X Y Li, S B Zhang, F Zhang, Y L Zhao
Objective: To investigate the health status, functional ability, mental psychology, health care and other longevity-related characteristics of individuals aged ≥100 years as well as risk factors in Hainan province, China. Methods: China Hainan Centenarian Cohort Study (CHCCS) is a community-based, prospective cohort study to establish multi-dimensional database consisting of questionnaire findings, anthropometric parameters and biological specimens as well as imaging features. With the household registration information provided by the Department of Civil Affairs of Hainan province, a baseline survey was conducted in centenarians in 18 counties in Hainan with the oldest old in 5 counties as controls between 2014 and 2017...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28906390/empathy-and-burnout-of-emergency-professionals-of-a-health-region-a-cross-sectional-study
#6
Oriol Yuguero, Carles Forné, Montserrat Esquerda, Josep Pifarré, María José Abadías, Joan Viñas
The objective of this study is to assess the association between levels of empathy and burnout of emergency professionals in all the assistance levels.A cross-sectional observational study was conducted in the health region of Lleida and the Pyrenees with 100 professionals from the field of Urgency. Participation reached 40.8%. Empathy and burnout were measured using the Spanish versions of the Jefferson Scale of Physician Empathy (JSPE) and Maslach Burnout Inventory (MBI) respectively. The total MBI score and its 3 dimensions (emotional exhaustion, depersonalization, and personal accomplishment) were analyzed...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906036/phosphorus-and-fluorine-co-doping-induced-enhancement-of-oxygen-evolution-reaction-in-bimetallic-nitride-nanorods-arrays-ionic-liquid-driven-and-mechanism-clarification
#7
Xue Bai, Qin Wang, Feng He, Zhi-Jian Wu, Guangran Xu, Keke Huang, Yunkun Ning, Jun Zhang
Electrocatalytic splitting of water is becoming increasingly crucial for renewable energy and device technologies. As one of the most important half-reactions for water splitting reaction, oxygen evolution reaction (OER) is a kinetically sluggish process that will greatly affect the energy conversion efficiency. Therefore, exploring a highly efficient, and durable catalyst to boost the OER is of great urgency. In this work, we develop a facile strategy for synthesis of well-defined phosphorus, fluorine co-doped Ni1...
September 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28905793/re-reduction-of-urgency-severity-is-the-most-important-factor-in-the-subjective-therapeutic-outcome-of-intravesical-onabotulinumtoxina-injection-for-overactive-bladder
#8
https://www.readbyqxmd.com/read/28904950/quantitative-changes-in-cerebral-perfusion-during-urinary-urgency-in-women-with-overactive-bladder
#9
Nisha G Arya, Steven J Weissbart, Sihua Xu, Rupal Bhavsar, Hengyi Rao
PURPOSE: To quantitatively measure changes in cerebral perfusion in select regions of interest in the brain during urinary urgency in women with overactive bladder (OAB) using arterial spin labeling (ASL). METHODS: Twelve women with OAB and 10 controls underwent bladder filling and rated urinary urgency (scale 0-10). ASL fMRI scans were performed (1) in the low urgency state after voiding and (2) high urgency state after drinking oral fluids. Absolute regional cerebral blood flow (rCBF) in select regions of interest was compared between the low and high urgency states...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28904925/a-rare-case-of-transvesical-cesarean-section
#10
Sunil Kumar Juneja, Pooja Tandon, Bakul Kochhar, Harman Deep Singh, Bhanupriya Sharma
Cesarean section, also commonly known as C-section, is a surgical procedure in which incision is made through a mother's abdomen and uterus to deliver one or more babies. According to urgency, they are classified either as elective or emergency. According to technique, they have been classified as classical, lower uterine segment and cesarean hysterectomy. Intentional transvesical cesarean though not a routinely practiced technique is used for delivery in women born with imperforate anus, ectopic intravaginal urethra, vaginal and urethral strictures, and bladder adherent completely over the uterus...
July 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28900813/assessment-of-acute-bowel-function-after-radiotherapy-for-prostate-cancer-is-it-accurate-enough
#11
M Bonet, L Cayetano, M Núñez, E Jovell-Fernández, A Aguilar, Y Ribas
BACKGROUND AND PURPOSE: Pelvic radiotherapy for prostate cancer can be associated with bowel toxicity, which may have a significant impact on quality of life. Our aim was to assess the adequacy of the tools currently used to assess bowel symptoms after radiotherapy, including physician and patient reported outcomes. This sub-study on acute toxicity was part of a prospective trial assessing long-term bowel dysfunction. MATERIALS AND METHODS: Between February 2013 and July 2015, 75 patients with prostate cancer who received radiotherapy completed the LENT/SOMA and the EPIC questionnaires baseline and 2 weeks after the treatment...
September 12, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28900355/distribution-of-blatem-blashv-and-blactx-m-genes-among-esbl-producing-p-aeruginosa-isolated-from-qazvin-and-tehran-hospitals-iran
#12
REVIEW
A Peymani, T Naserpour-Farivar, E Zare, K H Azarhoosh
INTRODUCTION: Pseudomonas aeruginosa is as an important opportunistic human pathogen, which is associated with several clinical infections that are usually difficult to treat because of resistance to multiple antimicrobials. The production of extendedspectrum ß-lactamases (ESBLs) is an important mechanism of ß-lactam resistance. The aims of this study were to determine the prevalence of ESBLs, antimicrobial susceptibility, and to detect the blaTEM, blaSHV, and blaCTX-M genes. METHODS: In this study, carried out from March 2013 to December 2014, 266 P...
June 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28893405/genome-editing-for-global-food-security
#13
Xingliang Ma, Martin Mau, Timothy F Sharbel
Global food security is increasingly challenging in light of population increase, the impact of climate change on crop production, and limited land available for agricultural expansion. Here we outline how genome editing provides excellent and timely methods to optimize crop plants, and argue the urgency for societal acceptance and support.
September 8, 2017: Trends in Biotechnology
https://www.readbyqxmd.com/read/28893200/an-after-hours-gp-clinic-in-regional-australia-appropriateness-of-presentations-and-impact-on-local-emergency-department-presentations
#14
Kristy Payne, Tegan Dutton, Kate Weal, Maree Earle, Ross Wilson, Jannine Bailey
BACKGROUND: After hours general practice clinics provide medical attention for clients with non-emergency situations but are seeking immediate treatment and unable to wait for a general practitioner during routine opening hours. Evidence on the impact that after hours clinics have on emergency department presentations is equivocal. This study explored outcomes of the Bathurst After Hours General Practice Clinic (BAHGPC). Specifically it examined: clients' perceived urgency of, and satisfaction with their presentation to the BAHGPC; general practitioners' perception of the appropriateness of presentations to the BAHGPC; and whether the frequency of non-urgent and semi-urgent emergency department presentations at Bathurst Base Hospital has changed since the opening of the BAHGPC...
September 11, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28892501/implementation-of-a-study-to-examine-the-persistence-of-ebola-virus-in-the-body-fluids-of-ebola-virus-disease-survivors-in-sierra-leone-methodology-and-lessons-learned
#15
Gibrilla Fadlu Deen, Suzanna L R McDonald, Jaclyn E Marrinan, Foday R Sesay, Elizabeth Ervin, Anna E Thorson, Wenbo Xu, Ute Ströher, Patricia Ongpin, Neetu Abad, Archchun Ariyarajah, Tasneem Malik, Hongtu Liu, Christine Ross, Kara N Durski, Philippe Gaillard, Oliver Morgan, Pierre Formenty, Barbara Knust, Nathalie Broutet, Foday Sahr
BACKGROUND: The 2013-2016 West African Ebola virus disease epidemic was unprecedented in terms of the number of cases and survivors. Prior to this epidemic there was limited data available on the persistence of Ebola virus in survivors' body fluids and the potential risk of transmission, including sexual transmission. METHODOLOGY/PRINCIPAL FINDINGS: Given the urgent need to determine the persistence of Ebola virus in survivors' body fluids, an observational cohort study was designed and implemented during the epidemic response operation in Sierra Leone...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28892221/a-novel-leadless-miniature-implantable-tibial-nerve-neuromodulation-system-for-the-management-of-overactive-bladder-complaints
#16
John P F A Heesakkers, Guiseppe A Digesu, Jetske van Breda, Philip Van Kerrebroeck, Sohier Elneil
BACKGROUND: Overactive bladder is a chronic condition affecting lower urinary tract function that has a significant negative impact on QoL. OBJECTIVE: Evaluation of the BlueWind implantable tibial nerve system performance and safety in refractory OAB. DESIGN, SETTING, AND PARTICIPANTS INTERVENTION: A 6-month multi-center prospective intervention study. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Objective assessment was done by voiding diary parameters included voids/day, volume voided/day, urgency assessment, leaking episodes/day, pads used/day, leak severity, and clinical success defined as a ≥50% reduction in the number of leaks/day or number of voids/day or number of episodes with degree of urgency >2 or a return to <8 voids/day on a 3 Day diary...
September 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28891795/-intravesical-botulinum-toxin-under-local-anestesia-as-ambulatory-procedure
#17
José Javier Fabuel Alcañiz, Laura Martínez Arcos, Miguel Jimenez Cidre, Francisco Javier Burgos Revilla
Bladder hyperactivity is described as the presence of "voiding urgency, generally associated with increased daytime frequency and nocturia, with or without urinary incontinence, in the absence of urinary tract infection or other obvious pathology". Onabotulinum toxin A (BTA) is a recommendable therapeutic option in case of failure, contraindication or refusal of the conservative therapy or other non-pharmacological therapies. The injection of BTA in the detrusor has been performed under local, regional or general anesthesia either in the conventional or major ambulatory surgery operative room or in the cystoscopy room...
September 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28890225/early-life-stress-predicts-negative-urgency-through-brooding-depending-on-5-httlpr-genotype-a-pilot-study-with-6-month-follow-up-examining-suicide-ideation
#18
Jorge Valderrama, Regina Miranda
The present study examined the interaction between early life stress and 5-HTT genotypes in predicting two risk factors for suicidal behavior - the brooding subtype of rumination and impulsivity, in the form of negative urgency - over time. Furthermore, we examined early life stress, brooding, and impulsivity as predictors of suicidal ideation over time. Participants with and without a history of early life stress were genotyped for the 5-HTTLPR polymorphism and completed assessments assessing brooding and negative urgency at baseline and 6-month follow up...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28890140/-impact-of-the-elderly-patient-in-the-emergency-department
#19
Manuel Bermúdez Menéndez de la Granda, German Guzmán Gutiérrez, María Fernández Fernández, Juan José Solano Jaurrieta
INTRODUCTION: The aging of the population, chronic diseases, and non-urgent visits to the Emergency departments (ED) are considered the reasons for the increase of the demand of care. The aim of this study is to analyse the impact of the older population in the ED, when compared to a younger population. MATERIAL AND METHODS: An observational, descriptive and retrospective study including an analysis of the 92,627 patients that attended the ED in Hospitals from Health Area IV belonging to the Principality of Asturias Health Services during 2009...
September 7, 2017: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/28889385/the-n-butyl-n-4-hydroxybutyl-nitrosamine-mouse-urinary-bladder-cancer-model
#20
Paula A Oliveira, Cármen Vasconcelos-Nóbrega, Rui M Gil da Costa, Regina Arantes-Rodrigues
Urinary bladder cancer (UBC) is a common and complex malignancy, with a multifactorial etiology, like environmental factors, such as cigarette smoking, occupational exposure, and genetic factors.UBC exhibits considerable genotypic and phenotypic heterogeneity. Among all UBC lesions, urothelial carcinoma is the most frequently observed histological type. Despite all the developments made in urologic oncology field, therapeutic options remain inadequate. There is urgency for the identification and development of new antineoplastic drugs to replace or improve current protocols and in vivo models have been proven to be essential for this step...
2018: Methods in Molecular Biology
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