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https://www.readbyqxmd.com/read/28445996/energy-transfer-in-ce0-85tb0-15f3-nanoparticles-ctab-shell-chlorin-e6-system
#1
Mykhaylo Yu Losytskyy, Liliia V Kuzmenko, Oleksandr B Shcherbakov, Nikolai F Gamaleia, Andrii I Marynin, Valeriy M Yashchuk
Formation and electronic excitation energy transfer process in the nanosystem consisting of Ce0.85Tb0.15F3 nanoparticles, cetrimonium bromide (CTAB) surfactant, and chlorin e6 photosensitizer were studied. It was shown that chlorin e6 molecules bind to Ce0.85Tb0.15F3 NP in the presence of CTAB forming thus Ce0.85Tb0.15F3 NP-CTAB-chlorin e6 nanosystem. We consider that binding occurs via chlorin e6 embedding in the shell of CTAB molecules, formed around NP. In the Ce0.85Tb0.15F3 NP-CTAB-chlorin e6 nanosystem, electronic excitation energy transfer from Ce(3+) to chlorin e6 takes place both directly (with the 0...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28445109/distinct-prevalence-of-drug-resistant-tuberculosis-in-gansu-china-a-retrospective-study-on-drug-susceptibility-profiles-between-2010-and-2014
#2
XingFang Li, Lei Wang, Yanling Tan, Jun Hou, Jianjun Ma
Limited knowledge is available on regional distribution of antituberculosis (TB) drug resistance and on province-specific time-trends in TB drug susceptibility in China. To obtain the latest information about the dynamics of drug-resistant TB in Gansu province, we conducted a retrospective study and analyzed data on drug resistance among new TB cases diagnosed between June 2010 and May 2014 in Gansu, China. The data were collected from the only TB surveillance and treatment hospital in Gansu and, therefore, represented the epidemiology of TB in the province...
April 26, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28445012/drug-resistance-patterns-of-multidrug-and-extensively-drug-resistant-tuberculosis-in-korea-amplification-of-resistance-to-oral-second-line-drugs
#3
Chang Ki Kim, So Youn Shin, Hee Jin Kim, Kyungwon Lee
We aimed to analyze the drug resistance patterns of multidrug-resistant and extensively drug-resistant tuberculosis (TB) and the difference of drug resistance among various settings for health care in Korea. The data of drug susceptibility testing in 2009 was analyzed in order to secure sufficient number of patients from various settings in Korea. Patients were categorized by types of institutions into four groups, which comprised new and previously treated patients from public health care centers (PHC), the private sector, and Double-barred Cross clinics (DBC)...
July 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28444006/scale-up-of-collaborative-tb-hiv-activities-in-guyana
#4
Brian J Baker, Brandy Peterson, Jeetendra Mohanlall, Shanti Singh, Collene Hicks, Ruth Jacobs, Ruth Ramos, Barbara Allen, Eric Pevzner
Objective: To assess scale-up of recommended tuberculosis (TB)/HIV activities in Guyana and to identify specific strategies for further expansion. Methods: Medical records and clinic registers were reviewed at nine TB clinics and 10 HIV clinics. At TB clinics, data were collected on HIV testing and antiretroviral therapy (ART) for patients with TB/HIV; at HIV clinics, data were collected on intensified case finding (ICF), tuberculin skin test (TST) results, and provision of isoniazid preventive therapy (IPT)...
April 20, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28443511/current-approaches-and-future-prospects-of-nanomedicines-in-tuberculosis-therapy
#5
Md Tanwir Athar, Zabih Ullah
Tuberculosis (TB), which is caused by the Mycobacterium tuberculosis, is a serious threat and one of the major health problems worldwide. In recent years, an estimated of 9.6 million TB cases occurred and 1.5 million death occurred due to TB worldwide. The present review is an attempt to introduce this disease focusing on the pathophysiology of the disease, the current approachesand the related patents for treatment and the future planningfor combating this disease.
April 25, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/28443279/analogs-of-the-frog-skin-antimicrobial-peptide-temporin-1tb-exhibit-a-wider-spectrum-of-activity-and-a-stronger-antibiofilm-potential-as-compared-to-the-parental-peptide
#6
Lucia Grassi, Giuseppantonio Maisetta, Giuseppe Maccari, Semih Esin, Giovanna Batoni
The frog skin-derived peptide Temporin 1Tb (TB) has gained increasing attention as novel antimicrobial agent for the treatment of antibiotic-resistant and/or biofilm-mediated infections. Nevertheless, such a peptide possesses a preferential spectrum of action against Gram-positive bacteria. In order to improve the therapeutic potential of TB, the present study evaluated the antibacterial and antibiofilm activities of two TB analogs against medically relevant bacterial species. Of the two analogs, TB_KKG6A has been previously described in the literature, while TB_L1FK is a new analog designed by us through statistical-based computational strategies...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28443247/evaluation-of-a-new-ifn-%C3%AE-release-assay-for-rapid-diagnosis-of-active-tuberculosis-in-a-high-incidence-setting
#7
Gen Li, Feng Li, Hui-Min Zhao, Han-Li Wen, Hai-Cong Li, Chun-Ling Li, Ping Ji, Peng Xu, Kang Wu, Zhi-Dong Hu, Shui-Hua Lu, Douglas B Lowrie, Jian-Xin Lv, Xiao-Yong Fan
Blood-based interferon-gamma (IFN-γ) release assays (IGRAs) have been proven to be useful in the diagnosis of Mycobacterium tuberculosis (Mtb) infection. However, IGRAs have not been recommended for clinical practice in most low-income settings due to cost-intensive limitations and shortage of clinical data available. The established T-SPOT. TB assay containing Mtb-specific antigens ESAT-6 and CFP10 are widely used for immunodiagonsis of Mtb infection, but the high cost is one of the restricting factors against its clinical application in the developing countries...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28442556/short-course-treatment-for-mdr-tb-jumping-the-gun
#8
EDITORIAL
Anna Turkova, Beate Kampmann
No abstract text is available yet for this article.
April 25, 2017: Thorax
https://www.readbyqxmd.com/read/28442117/tuberculosis-toxoplasmosis-co-infection-in-egyptian-patients-a-reciprocal-impact
#9
Mervat Mashaly, Nairmen Nabih, Iman M Fawzy, Abeer A El Henawy
OBJECTIVE: To assess the concurrent toxoplasmosis infection in Egyptian TB patients and the impact of each infection on the other in terms of increased severity of TB or reactivation of latent Toxoplasma infection. METHODS: Three hundred suspected pulmonary TB cases were initially screened for TB using direct Ziehl Neelsen staining and Lowenstein Jensen culture of their sputa. Rifampicin resistance was detected by Xpert MTB/RIF assay. Control group of 30 age and sex-matched healthy individuals negative for TB was included for comparison...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28440617/anchoring-tailored-low-index-faceted-biobr-nanoplates-onto-tio2-nanorods-to-enhance-the-stability-and-visible-light-driven-catalytic-activity
#10
Chao Xue, Tianxi Zhang, Shujiang Ding, Jinjia Wei, Guidong Yang
In this work, a fantastic one-dimensional (1D) BiOBr/TiO2 nanorods (NRs) heterojunction composite was rationally proposed and designed from the perspective of molecular and interface engineering. The fabricated intimately connected interfacial heterojunction between two-dimensional (2D) BiOBr nanoplates and 1D TiO2 NRs acts as the interfacial nano-channel to promote efficient interfacial charge migration and the separation of photogenerated electron-hole pairs. As a result, 1D BiOBr/TiO2 NRs heterojunctions exhibited outstanding visible-light photocatalytic activities and sustained cycling performance...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28440604/a-proposed-novel-framework-for-monitoring-and-evaluation-of-the-cascade-of-hiv-associated-tb-care-at-the-health-facility-level
#11
Colleen F Hanrahan, Annelies Van Rie
INTRODUCTION: The rapid and accurate diagnosis of HIV-associated tuberculosis (TB), timely initiation of curative or preventative treatment and assurance of favourable treatment outcomes is a complex process. The current system of monitoring and reporting TB diagnosis and treatment does not include several key aspects of the care cascade, and may obscure systematic bottlenecks, inefficiencies or sources of sub-optimal care. METHODS: We critically reviewed the current World Health Organizations recommended system of monitoring and reporting, and identified the following key deficiencies that could limit the ability of healthcare workers to identify structural problems in the provision of TB/HIV care...
April 20, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28439071/diabetes-mellitus-and-the-risk-of-multidrug-resistant-tuberculosis-a-meta-analysis
#12
Qianqian Liu, Wenzhang Li, Miao Xue, Yunfeng Chen, Xinmiao Du, Chengdi Wang, Lina Han, Yin Tang, Yulin Feng, Chuanmin Tao, Jian-Qing He
The high prevalence of diabetes mellitus (DM) among multidrug resistant tuberculosis (MDR-TB) patients is a serious cause for concern. We conducted a meta-analysis to determine whether DM is an independent risk factor for MDR-TB. Electronic literature searches of the PubMed, Web of Science and EMBASE databases up to July 12, 2016 were conducted. The pooled adjusted odds ratio (OR) and 95% confidence intervals (CIs) were calculated using the random effects model with STATA 12.0 software. In total 13 studies, including 9289 individuals with TB, were included in this meta-analysis...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438994/latently-and-uninfected-healthcare-workers-exposed-to-tb-make-protective-antibodies-against-mycobacterium-tuberculosis
#13
Hao Li, Xing-Xing Wang, Bin Wang, Lei Fu, Guan Liu, Yu Lu, Min Cao, Hairong Huang, Babak Javid
The role of Igs in natural protection against infection by Mycobacterium tuberculosis (Mtb), the causative agent of TB, is controversial. Although passive immunization with mAbs generated against mycobacterial antigens has shown protective efficacy in murine models of infection, studies in B cell-depleted animals only showed modest phenotypes. We do not know if humans make protective antibody responses. Here, we investigated whether healthcare workers in a Beijing TB hospital-who, although exposed to suprainfectious doses of pathogenic Mtb, remain healthy-make antibody responses that are effective in protecting against infection by Mtb...
April 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28438617/tumor-budding-as-a-risk-factor-for-nodal-metastasis-in-pt1-colorectal-cancers-a-meta-analysis
#14
Rocco Cappellesso, Claudio Luchini, Nicola Veronese, Marcello Lo Mele, Erik Rosa-Rizzotto, Ennio Guido, Franca De Lazzari, Pierluigi Pilati, Fabio Farinati, Stefano Realdon, Marco Solmi, Matteo Fassan, Massimo Rugge
Worldwide, colorectal cancer (CRC) screening programs have significantly increased the detection of sub-mucosal (pT1) adenocarcinoma. Completion surgery may be indicated after endoscopic excision of these potentially metastasizing early cancers. However, the post-surgical prevalence of nodal implants does not exceed 15%, leading to questions concerning the clinical appropriateness of any post-endoscopy surgery. Eastern scientific societies (Japanese Society for Cancer of the Colon-Rectum, in particular) include tumor budding (TB), defined as the presence of isolated single cancer cells or clusters of fewer than five cancer cells at the tumor invasive front, among the variables that must be included in histological reports...
April 21, 2017: Human Pathology
https://www.readbyqxmd.com/read/28438554/interleukin-17f-and-interleukin-6-gene-polymorphisms-in-asian-indian-patients-with-takayasu-arteritis
#15
Debashish Danda, Ruchika Goel, Sumita Danda, Hindhumathi Mohan, George Joseph, Jayakanthan Kabeerdoss, Swapan K Nath
OBJECTIVES: To assess genetic association between single nucleotide polymorphisms (SNPs) in genes encoding T-helper cytokines and Takayasu Arteritis (TA) susceptibility in Indian population. METHODS: In Phase-1, the genomic DNA of 120 TA patients and 119 healthy controls were genotyped for SNPs rs1800795 (interleukin (IL)-6), rs763780 (IL-17F), rs1800871, rs1800872, rs1800896 (IL-10) and rs1800468, rs1800469, rs1800470 (transforming growth factor-β). Allele frequencies between cases and controls were compared using chi-squared test and also reassessed empirically (pe) by 10,000 permutations...
April 21, 2017: Human Immunology
https://www.readbyqxmd.com/read/28438462/comparison-of-interferon-%C3%AE-release-assays-quantiferon-tb-git-and-t-spot-tb-in-renal-transplantation
#16
Satoru Ishikawa, Hidetoshi Igari, Naotake Akutsu, Mizue Tsuyuzaki, Hiromichi Aoyama, Masayuki Hasegawa, Kazunori Otsuki, Michihiro Maruyama, Kenichi Saigo, Kiminori Suzuki, Fumio Yamagishi
Renal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and progressing to active tuberculosis (TB). This study was conducted in National hospital for tuberculosis and renal transplantation (RT) in Japan. The purpose is to compare two interferon-γ release assays (IGRAs), QuantiFERON(®)-TB Gold in Tube (QFT) and T-SPOT(®).TB (TSPOT), in patients after renal transplantation for detecting latent TB infection (LTBI). Total 92 renal transplant recipients (median age 46 years, range 17-75) were prospectively enrolled, and QFT and TSPOT were concurrently examined...
April 21, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28438143/erratum-to-high-pre-diagnosis-attrition-among-patients-with-presumptive-mdr-tb-an-operational-research-from-bhopal-district-india
#17
Hemant Deepak Shewade, Arun M Kokane, Akash Ranjan Singh, Manoj Verma, Malik Parmar, Ashish Chauhan, Sanjay Singh Chahar, Manoj Tiwari, Sheeba Naz Khan, Vivek Gupta, Jaya Prasad Tripathy, Mukesh Nagar, Sanjai Kumar Singh, Pradeep Kumar Mehra, Ajay M V Kumar
No abstract text is available yet for this article.
April 24, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28438139/digital-cxr-with-computer-aided-diagnosis-versus-symptom-screen-to-define-presumptive-tuberculosis-among-household-contacts-and-impact-on-tuberculosis-diagnosis
#18
Monde Muyoyeta, Nkatya Chanda Kasese, Deborah Milimo, Isaac Mushanga, Mapopa Ndhlovu, Nathan Kapata, Maureen Moyo-Chilufya, Helen Ayles
BACKGROUND: Household (HH) contact tracing is a strategy that targets high risk groups for TB. Symptom based screening is the standard used to identify HH contacts at risk for TB during HH contact tracing for TB. However, this strategy may be limited due to poor performance in predicting TB. The objective of this study was to compare CXR with Computer Aided Diagnosis (CAD) against symptom screen for defining presumptive TB and how TB detection changes with each method. METHODS: Household contacts of consecutive index bacteriologically confirmed TB cases were visited by study teams and given TB/HIV education to raise awareness of the risk of TB following close contact with a TB patient...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28438132/early-detection-of-multidrug-and-pre-extensively-drug-resistant-tuberculosis-from-smear-positive-sputum-by-direct-sequencing
#19
Jun Chen, Peng Peng, Yixiang Du, Yi Ren, Lifeng Chen, Youyi Rao, Weihua Wang
BACKGROUND: Emergence of multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) is a major hurdle for TB control programs especially in developing countries like China. Resistance to fluoroquinolones is high among MDR-TB patients. Early diagnosis of MDR/pre-XDR-TB is essential for lowering transmission of drug-resistant TB and adjusting the treatment regimen. METHODS: Smear-positive sputum specimens (n = 186) were collected from Wuhan Institute for Tuberculosis Control...
April 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28438118/predictors-of-delayed-culture-conversion-among-ugandan-patients
#20
Daniel Atwine, Patrick Orikiriza, Ivan Taremwa, Arnold Ayebare, Suzan Logoose, Juliet Mwanga-Amumpaire, Amina Jindani, Maryline Bonnet
BACKGROUND: Estimates of month-2 culture conversion, a proxy indicator of tuberculosis (TB) treatment efficacy in phase-2 trials can vary by culture-type and geographically with lower rates reported among African sites. The sub-study aimed at comparing TB detection rates of different culture media, within and across rifampicin-based regimens (R10, 15 and 20 mg/Kg) over a 6-month treatment follow-up period, and to establish predictors of month-2 culture non-conversion among HIV-negative TB patients enrolled at RIFATOX trial site in Uganda...
April 24, 2017: BMC Infectious Diseases
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