keyword
MENU ▼
Read by QxMD icon Read
search

TB

keyword
https://www.readbyqxmd.com/read/29166403/integration-of-molecular-typing-results-into-tuberculosis-surveillance-in-germany-a-pilot-study
#1
Marta Andrés, Elke Göhring-Zwacka, Lena Fiebig, Martin Priwitzer, Elvira Richter, Sabine Rüsch-Gerdes, Walter Haas, Stefan Niemann, Bonita Brodhun
An integrated molecular surveillance for tuberculosis (TB) improves the understanding of ongoing TB transmission by combining molecular typing and epidemiological data. However, the implementation of an integrated molecular surveillance for TB is complex and requires thoughtful consideration of feasibility, demand, public health benefits and legal issues. We aimed to pilot the integration of molecular typing results between 2008 and 2010 in the German Federal State of Baden-Württemberg (population 10.88 Million) as preparation for a nationwide implementation...
2017: PloS One
https://www.readbyqxmd.com/read/29166305/botulinum-toxin-therapy-is-syringe-type-related-to-cost-effectiveness
#2
Mark Anthony Foglietti, Lauren Wright, Alanna Foglietti-Fostyk
INTRODUCTION: Clostridium botulinum toxin is effective through cleaving presynaptic proteins at the neuromuscular junction, which prevents the release of acetylcholine and inhibits muscle contraction. Several serotypes of botulinum toxin (BT) exist; however, only 2 types have been approved by the US Food and Drug Administration for commercial and medical use, A and B. Both types of BT must be administered intramuscularly with a syringe, but the type of syringe is the injector's preference...
November 21, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29166003/hydrogenation-properties-of-laves-phases-lnmg2-ln-la-ce-pr-nd-sm-eu-gd-tb-ho-er-tm-yb
#3
Anton Werwein, Florian Maaß, Leonhard Y Dorsch, Oliver Janka, Rainer Pöttgen, Thomas C Hansen, Justin Kimpton, Holger Kohlmann
The hydrogenation properties of Laves phases LnMg2 (Ln = La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Ho, Er, Tm, Yb) were investigated by thermal analysis, X-ray, synchrotron, and neutron powder diffraction. At 14.0 MPa hydrogen gas pressure and 393 K, PrMg2 and NdMg2 take up hydrogen and form the colorless, ternary hydrides PrMg2H7 (P41212, a = 632.386(6) pm, c = 945.722(11) pm) and NdMg2H7 (P41212, a = 630.354(9) pm, c = 943.018(16) pm). The crystal structures were refined by the Rietveld method from neutron powder diffraction data on the deuterides (PrMg2D7, P41212, a = 630...
November 22, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29165702/trend-of-tuberculosis-case-notification-and-treatment-outcome-in-lagos-state-nigeria-a-5-year-retrospective-study
#4
Olusola A Adejumo, Olusoji J Daniel, Husseine A Abdur-Razzaq, Yeside O Shogbamimu, Toriola Femi-Adebayo, Victor A Adepoju, Bisola I Adebayo, Oluwajimi O Sodipo
Background: This study assessed trends of tuberculosis (TB) case notification rate (CNR) and treatment outcomes between 2011 and 2015 in Lagos State, Nigeria. Methods: A retrospective review of TB notification data to the Lagos State Tuberculosis and Leprosy Control Programme (LSTBLCP) between 1 January 2011 and 31 December 2015 was conducted. Results: A total of 44 516 TB cases were notified during the study period, representing 9.4% of the national figure...
November 20, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29165665/novel-structural-features-drive-dna-binding-properties-of-cmr-a-crp-family-protein-in-tb-complex-mycobacteria
#5
Sridevi Ranganathan, Jonah Cheung, Michael Cassidy, Christopher Ginter, Janice D Pata, Kathleen A McDonough
Mycobacterium tuberculosis (Mtb) encodes two CRP/FNR family transcription factors (TF) that contribute to virulence, Cmr (Rv1675c) and CRPMt (Rv3676). Prior studies identified distinct chromosomal binding profiles for each TF despite their recognizing overlapping DNA motifs. The present study shows that Cmr binding specificity is determined by discriminator nucleotides at motif positions 4 and 13. X-ray crystallography and targeted mutational analyses identified an arginine-rich loop that expands Cmr's DNA interactions beyond the classical helix-turn-helix contacts common to all CRP/FNR family members and facilitates binding to imperfect DNA sequences...
November 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29165509/-evaluation-of-xpert%C3%A2-mtb-rif-technique-for-mycobacterium-tuberculosis-complex-detection-in-extra-respiratory-specimens
#6
Patricia García, M Elvira Balcells, Claudia Castillo, Carolina Miranda, Enrique Geoffroy, Juan C Román, Aniela Wozniak
Extra-pulmonary tuberculosis (TB) represents the 26.2% of total TB cases in Chile. Culture is the gold standard method, but the process is extremely slow. Xpert®MTB/RIF technique detects Mycobacterium tuberculosis complex (MTBc) through real time PCR in less than 3 h. However, it has been validated only for respiratory specimens. We aimed to determine the performance of Xpert®MTB/RIF test in detecting MTBc in extra-respiratory specimens compared with a combined gold standard consisting in a positive (liquid and solid) mycobacterial culture and/or a positive validated molecular method (q-RPC, Cobas®TaqMan®-MTB)...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29165080/tuberculosis-treated-by-multiple-drugs-an-overview
#7
Gyanendra Singh, Prashant Kesharwani, A K Shrivastava
Current tuberculosis (TB) treatment is established on an amalgamation of drugs that were evolved mostly in the central decades of the hind century. Cure rates are elevated for drug-sensitive strains of Mycobacterium tuberculosis (M.Tb) when the recommended complex and prolonged treatment protocols adhere. However, the difficulty in accurately prescribing and adhering to these protocols and the emergence of M. Tb strains resistant to multiple drugs and drug-drug interactions that interfere with optimal treatment of Tuberculosis and co-infected patients with the different disease has generated a pressing need for improved Tuberculosis therapies...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29164169/tuberculosis-patients-who-are-a-potential-source-for-unprotected-exposure-in-health-care-systems-a-multicenter-case-control-study
#8
Jose Cadena, Norys A Castro-Pena, Heta Javeri, Brian Hernandez, Joel Michalek, Ana Fuentes Arzola, Miloni Shroff, Chetan Jinadatha, Gustavo Valero, Jason Bowling, Jean Przykucki, Michele Adams, James Jorgensen, Jan E Patterson, Pranavi Sreeramoju
Setting: Five health care systems in Texas. Objective: To describe the epidemiology of inadequate isolation for pulmonary tuberculosis leading to tuberculosis (TB) exposures from confirmed TB patients and the patient factors that led to the exposures. Design: A retrospective cohort and case-control study of adult patients with TB resulting in exposures (cases) vs those TB patients who did not result in exposures (controls) during January 2005 to December 2012...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29164066/application-of-immunoscore-model-for-the-differentiation-between-active-tuberculosis-and-latent-tuberculosis-infection-as-well-as-monitoring-anti-tuberculosis-therapy
#9
Yu Zhou, Juan Du, Hong-Yan Hou, Yan-Fang Lu, Jing Yu, Li-Yan Mao, Feng Wang, Zi-Yong Sun
Tuberculosis (TB) is a leading global public health problem. To achieve the end TB strategy, non-invasive markers for diagnosis and treatment monitoring of TB disease are urgently needed, especially in high-endemic countries such as China. Interferon-gamma release assays (IGRAs) and tuberculin skin test (TST), frequently used immunological methods for TB detection, are intrinsically unable to discriminate active tuberculosis (ATB) from latent tuberculosis infection (LTBI). Thus, the specificity of these methods in the diagnosis of ATB is dependent upon the local prevalence of LTBI...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29164047/cost-of-tuberculosis-treatment-evidence-from-iran-s-health-system
#10
Vahid Bay, Payam Tabarsi, Aziz Rezapour, Sima Marzban, Ehsan Zarei
Objectives: This study aimed to estimate the cost of smear-positive drug-susceptible pulmonary tuberculosis (TB) treatment of the patients in the Azadshahr district, Golestan Province, Iran. Methods: In this retrospective study, all new smear positive pulmonary TB patients who had been registered at the district's health network between April, 2013 and December, 2015 and had successfully completed their treatment were entered into the study (45 patients). Treatment costs were estimated from the provider's perspective using an activity-based costing (ABC) method...
October 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/29163551/host-antimicrobial-peptides-the-promise-of-new-treatment-strategies-against-tuberculosis
#11
REVIEW
Javier Arranz-Trullén, Lu Lu, David Pulido, Sanjib Bhakta, Ester Boix
Tuberculosis (TB) continues to be a devastating infectious disease and remerges as a global health emergency due to an alarming rise of antimicrobial resistance to its treatment. Despite of the serious effort that has been applied to develop effective antitubercular chemotherapies, the potential of antimicrobial peptides (AMPs) remains underexploited. A large amount of literature is now accessible on the AMP mechanisms of action against a diversity of pathogens; nevertheless, research on their activity on mycobacteria is still scarce...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163427/antimycobacterial-and-anti-inflammatory-mechanisms-of-baicalin-via-induced-autophagy-in-macrophages-infected-with-mycobacterium-tuberculosis
#12
Qingwen Zhang, Jinxia Sun, Yuli Wang, Weigang He, Lixin Wang, Yuejuan Zheng, Jing Wu, Ying Zhang, Xin Jiang
Tuberculosis (TB) remains a leading killer worldwide among infectious diseases and the effective control of TB is still challenging. Autophagy is an intracellular self-digestion process which has been increasingly recognized as a major host immune defense mechanism against intracellular microorganisms like Mycobacterium tuberculosis (Mtb) and serves as a key negative regulator of inflammation. Clinically, chronic inflammation surrounding Mtb can persist for decades leading to lung injury that can remain even after successful treatment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162752/systemic-thrombosis-due-to-pulmonary-tuberculosis
#13
Sameer Bansal, Ketaki Utpat, Jyotsna M Joshi
Pulmonary tuberculosis (TB) is an established cause of venous thrombosis. A few instances have been described with arterial thrombosis as well. It has been speculated that TB causes systemic hypercoagulability, which may lead to venous thrombosis. This may be the presenting phenomenon, may occur shortly after diagnosis of TB, or even after starting antitubercular therapy. We describe a patient of pulmonary TB, who presented with pulmonary thromboembolism, with both arterial as well as venous thrombosis, which resolved on antitubercular therapy...
July 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29162063/elevated-aspergillus-specific-antibody-levels-among-hiv-infected-ugandans-with-pulmonary-tuberculosis
#14
Richard Kwizera, Rosalind Parkes-Ratanshi, Iain D Page, Christine Sekaggya-Wiltshire, Joseph Musaazi, Jan Fehr, Barbara Castelnuovo, Andrew Kambugu, David W Denning
BACKGROUND: The incidence of tuberculosis (TB) is high among human immunodeficiency virus (HIV) infected Ugandans. Recent evidence suggests that Chronic Pulmonary Aspergillosis and Aspergillus sensitisation might be responsible for significant mortality in patients treated for tuberculosis in Uganda. METHODS: We retrieved and tested paired serum aliquots for 101 HIV-TB co-infected patients at the beginning and week 24 of TB treatment. We tested samples for Aspergillus-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) using ImmunoCAP®; and Aspergillus-specific IgG and total serum IgE using Immulite® immunoassays...
November 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29161962/purification-and-structural-analysis-of-volatile-sesquiterpenes-produced-by-escherichia-coli-carrying-unidentified-terpene-synthase-genes-from-edible-plants-of-the-family-araliaceae
#15
Kazutoshi Shindo, Jun-Ichiro Hattan, Mariko Kato, Miho Sato, Tomoko Ito, Yurika Shibuya, Arisa Watanabe, Maki Sugiyama, Yuri Nakamura, Norihiko Misawa
A simple method to purify volatile sesquiterpenes from recombinant Escherichia coli was developed using the cells that carried known sesquiterpene synthase (Tps) genes ZzZss2 (ZSS2) and ZoTps1. This method was applied for the purification and structural analyses of volatile sesquiterpenes produced by E. coli cells that carried unidentified Tps genes, which were isolated from the Aralia-genus edible plants belonging to the family Araliaceae. Recombinant cells carrying each Tps gene were cultured in the two-layer medium (n-octane/TB medium), and volatile sesquiterpenes trapped in n-octane were purified through two-phase partition, silica gel column chromatography, and reversed-phase preparative high-performance liquid chromatography, if necessary...
November 22, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29161842/mathematical-model-for-the-growth-of-mycobacterium-tuberculosis-in-the-granuloma
#16
Eduardo Ibarguen-Mondragon, Lourdes Esteva, Edith Mariela Burbano-Rosero
In this work we formulate a model for the population dynamics of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). Our main interest is to assess the impact of the competition among bacteria on the infection prevalence. For this end, we assume that Mtb population has two types of growth. The first one is due to bacteria produced in the interior of each infected macrophage, and it is assumed that is proportional to the number of infected macrophages. The second one is of logistic type due to the competition among free bacteria released by the same infected macrophages...
April 1, 2018: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29161834/a-tb-model-is-disease-eradication-possible-in-india
#17
Surabhi Pandey, Ezio Venturino
Tuberculosis (TB) is returning to be a worldwide global public health threat. It is estimated that 9.6 million cases occurred in 2014, of which just two-thirds notified to public health authorities. The "missing cases" constitute a severe challenge for TB transmission control. TB is a severe disease in India, while, worldwide, the WHO estimates that one third of the entire world population is infected. Nowadays, incidence estimation relies increasingly more on notifications of new cases from routine surveillance...
February 1, 2018: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29161379/strong-vertical-tb-programme-embedded-in-a-developing-primary-healthcare-system-impact-on-patient-and-community-experiences-in-cambodia
#18
Neisha Sundaram, Richard James, Um Sreynimol, Pen Linda, Joanne Yoong, Saint Saly, Pichenda Koeut, Mao Tan Eang, Richard Coker, Mishal Khan
No abstract text is available yet for this article.
November 17, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29161328/use-of-quantiferon%C3%A2-tb-gold-in-tube-culture-supernatants-for-measurement-of-antibody-responses
#19
Simon G Kimuda, Irene Andia-Biraro, Moses Egesa, Bernard S Bagaya, John G Raynes, Jonathan Levin, Alison M Elliott, Stephen Cose
QuantiFERON®-TB Gold in-tube (QFT-GIT) supernatants may be important samples for use in assessment of anti-tuberculosis (TB) antibodies when only limited volumes of blood can be collected and when a combination of antibody and cytokine measurements are required. These analytes, when used together, may also have the potential to differentiate active pulmonary TB (APTB) from latent TB infection (LTBI). However, few studies have explored the use of QFT-GIT supernatants for investigations of antibody responses...
2017: PloS One
https://www.readbyqxmd.com/read/29161276/association-between-diabetes-mellitus-and-active-tuberculosis-a-systematic-review-and-meta-analysis
#20
Rami H Al-Rifai, Fiona Pearson, Julia A Critchley, Laith J Abu-Raddad
The burgeoning epidemic of diabetes mellitus (DM) is one of the major global health challenges. We systematically reviewed the published literature to provide a summary estimate of the association between DM and active tuberculosis (TB). We searched Medline and EMBASE databases for studies reporting adjusted estimates on the TB-DM association published before December 22, 2015, with no restrictions on region and language. In the meta-analysis, adjusted estimates were pooled using a DerSimonian-Laird random-effects model, according to study design...
2017: PloS One
keyword
keyword
3162
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"