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https://www.readbyqxmd.com/read/28644497/novel-tunable-green-red-emitting-oxynitride-phosphors-co-activated-with-ce-3-tb-3-and-eu-3-photoluminescence-and-energy-transfer
#1
Jiansheng Huo, Langping Dong, Wei Lü, Baiqi Shao, Hongpeng You
A series of novel Ce(3+), Tb(3+) and Eu(3+) ion doped Y4SiAlO8N-based oxynitride phosphors were synthesized by the solid-state method and characterized by X-ray powder diffraction, scanning electron microscopy, photoluminescence, lifetimes and thermo-luminescence. The excitation of the Ce(3+)/Tb(3+) co-doped and Ce(3+)/Tb(3+)/Eu(3+) tri-doped phosphor with near-UV radiation results in strong linear Tb(3+) green and Eu(3+) red emission. The occurrence of Ce(3+)-Tb(3+) and Ce(3+)-Tb(3+)-Eu(3+) energy transfer processes is responsible for the bright green or red luminescence...
June 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28644388/cellular-uptake-and-delivery-dependent-effects-of-tb-3-doped-hydroxyapatite-nanorods
#2
Yan Wei, Ying He, Xiyu Li, Haifeng Chen, Xuliang Deng
With the increasing interest in hydroxyapatite (HA) nanostructures for use in biomedicine, the systematic evaluation of their potential effects on biological systems is becoming critically important. In this work, we report the in vitro cellular uptake, in vivo tissue distributions and toxicity of Tb(3+)-doped HA (HA-Tb) after short-, intermediate-, and long-term exposure. Transmission electron microscopy analysis indicated that HA-Tb was taken up by cells via vesicle endocytosis. Cell proliferation and cytotoxicity assay, combined with confocal laser scanning microscopy, indicated excellent cell viability with no changes in cell morphology at the examined doses...
June 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28644107/gingival-perfusion-and-tissue-biomarkers-during-early-healing-of-post-extraction-regenerative-procedures-a-prospective-case-series
#3
Lamees Alssum, Timothy D Eubank, Sashwati Roy, Barbaros S Erdal, Vedat O Yildiz, Dimitris N Tatakis, Binnaz Leblebicioglu
BACKGROUND: Post-extraction alveolar bone loss, mostly affecting the buccal plate, occurs despite regenerative procedures. To better understand possible determinants, this prospective case series assessed gingival blood perfusion and tissue molecular responses in relation to post-extraction regenerative outcomes. METHODS: Adults scheduled to receive bone grafting in maxillary, non-molar, single tooth extraction site were recruited. Clinical documentation included probing pocket depth (PD), keratinized tissue width (KT), tissue biotype (TB), plaque (P) and bleeding...
June 23, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28644016/color-tunable-and-white-light-luminescence-in-lanthanide-dicyanoaurate-coordination-polymers
#4
Ryan J Roberts, Debbie Le, Daniel B Leznoff
The new lanthanide-dicyanoaurate coordination polymers [(n)Bu4N]2[Ln(NO3)4Au(CN)2] (Ln = Sm, Dy) and Sm[Au(CN)2]3·3H2O were prepared and structurally characterized and their luminescence spectra described. The emissions of solid-solutions of [(n)Bu4N]2[Ln(NO3)4Au(CN)2] (Ln = Ce, Sm, Eu, Tb, and Dy) were explored with an emphasis on their capacity for luminescent color tuning and white-light emission via the selection of composition, excitation wavelength, and temperature. Specifically, the binary solid-solutions [(n)Bu4N]2[Ce0...
June 23, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28642848/mycobacterium-tuberculosis-glyceraldehyde-3-phosphate-dehydrogenase-gapdh-functions-as-a-receptor-for-human-lactoferrin
#5
Himanshu Malhotra, Anil Patidar, Vishant M Boradia, Rajender Kumar, Rakesh D Nimbalkar, Ajay Kumar, Zahid Gani, Rajbeer Kaur, Prabha Garg, Manoj Raje, Chaaya I Raje
Iron is crucial for the survival of living cells, particularly the human pathogen Mycobacterium tuberculosis (M.tb) which uses multiple strategies to acquire and store iron. M.tb synthesizes high affinity iron chelators (siderophores), these extract iron from host iron carrier proteins such as transferrin (Tf) and lactoferrin (Lf). Recent studies have revealed that M.tb may also relocate several housekeeping proteins to the cell surface for capture and internalization of host iron carrier protein transferrin...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28642843/the-impact-of-genome-region-of-difference-4-rd4-on-mycobacterial-virulence-and-bcg-efficacy
#6
Huanwei Ru, Xiaojia Liu, Chen Lin, Jingyan Yang, Fuzeng Chen, Ruifeng Sun, Lu Zhang, Jun Liu
Comparative genome analyses have revealed a number of regions of difference (RD) among mycobacterial species. The functional consequences of most of these genome variations have not been studied. RD4, which encompasses Rv1506c-Rv1516c of Mycobacterium tuberculosis (M. tb) H37Rv, is absent in the closely related Mycobacterium bovis and M. bovis Bacille Calmette-Guérin (BCG). On the other hand, we previously found that Mycobacterium marinum has an extended RD4 which includes a number of genes involved in the biosynthesis of lipooligosaccharides (LOSs)...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28642632/mcl-plays-an-anti-inflammatory-role-in-mycobacterium-tuberculosis-induced-immune-response-by-inhibiting-nf-%C3%AE%C2%BAb-and-nlrp3-inflammasome-activation
#7
Qingwen Zhang, Xinru Jiang, Weigang He, Kailin Wei, Jinxia Sun, Xiangyang Qin, Yuejuan Zheng, Xin Jiang
Mycobacterium tuberculosis (Mtb) remains a significant menace to global health as it induces granulomatous lung lesions and systemic inflammatory responses during active tuberculosis (TB). Micheliolide (MCL), a sesquiterpene lactone, was recently reported to have a function of relieving LPS-induced inflammatory response, but the regulative role of MCL on the immunopathology of TB still remains unknown. In this experiment, we examined the inhibitory effect of MCL on Mtb-induced inflammatory response in mouse macrophage-like cell line Raw264...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28642057/novel-multifunctional-dental-cement-to-prevent-enamel-demineralization-near-orthodontic-brackets
#8
Yansong Ma, Ning Zhang, Michael D Weir, Yuxing Bai, Hockin H K Xu
OBJECTIVES: White spot lesions due to biofilm acid-induced enamel demineralization are prevalent in orthodontic treatments. The aim of this study was to develop a novel bioactive multifunctional cement with protein-repellent, antibacterial and remineralizing capabilities, and investigate the effects on enamel hardness and lesion depth in vitro for the first time. MATERIALS AND METHODS: 2-Methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM), and nanoparticles of amorphous calcium phosphate (NACP) were incorporated into a resin-modified glass ionomer (RMGI)...
June 19, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28642013/identifying-mechanisms-driving-formation-of-granuloma-associated-fibrosis-during-mycobacterium-tuberculosis-infection
#9
Hayley C Warsinske, Robert M DiFazio, Jennifer J Linderman, JoAnne L Flynn, Denise E Kirschner
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a pulmonary pathogen of major global concern. A key feature of Mtb infection in primates is the formation of granulomas, dense cellular structures surrounding infected lung tissue. These structures serve as the main site of host-pathogen interaction in TB, and thus to effectively treat TB we must clarify mechanisms of granuloma formation and their function in disease. Fibrotic granulomas are associated with both good and bad disease outcomes...
June 19, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28641948/optimally-capturing-latency-dynamics-in-models-of-tuberculosis-transmission
#10
Romain Ragonnet, James M Trauer, Nick Scott, Michael T Meehan, Justin T Denholm, Emma S McBryde
Although different structures are used in modern tuberculosis (TB) models to simulate TB latency, it remains unclear whether they are all capable of reproducing the particular activation dynamics empirically observed. We aimed to determine which of these structures replicate the dynamics of progression accurately. We reviewed 88 TB-modelling articles and classified them according to the latency structure employed. We then fitted these different models to the activation dynamics observed from 1352 infected contacts diagnosed in Victoria (Australia) and Amsterdam (Netherlands) to obtain parameter estimates...
June 16, 2017: Epidemics
https://www.readbyqxmd.com/read/28641050/thrifty-females-frisky-males-winter-energetics-of-hibernating-bats-from-a-cold-climate
#11
Zenon J Czenze, Kristin A Jonasson, Craig K R Willis
Mammalian hibernation consists of energy-saving torpor bouts (periods of controlled reduction in body temperature [Tb]) interspersed with brief arousals to normothermic Tb. Frequency and duration of torpor bouts and arousals can affect winter survival and are thought to be influenced by an optimization balancing the energetic benefits of prolonged torpor against the physiological and ecological costs (e.g., accumulation of metabolic wastes). Female little brown bats (Myotis lucifugus) spend their fat reserves more slowly than males during winter, presumably so they can emerge from hibernation in good condition to initiate pregnancy...
July 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28640296/synthesis-and-photophysical-and-magnetic-studies-of-ternary-lanthanide-iii-complexes-of-naphthyl-chromophore-functionalized-imidazo-4-5-f-1-10-phenanthroline-and-dibenzoylmethane
#12
A Josephine Kanimozhi, V Alexander
The luminescent ternary lanthanide(iii) complexes [Ln(DBM)3(L1)] and [Ln(DBM)3(L2)] (Ln = Eu and Tb) of dibenzoylmethane (DBM) and 2-(2-naphthyl)-1H-imidazo[4,5-f][1,10]phenanthroline (L1) and 2-(2-hydroxy-1-naphthyl)-1H-imidazo[4,5-f][1,10]phenanthroline (L2) are reported in this work. The naphthyl chromophore functionalized imidazophenanthroline ligands L1 and L2 are structurally characterized by using single crystal X-ray diffraction: (L1), a = 14.933(4) Å, b = 7.4965(13) Å, c = 15.999(4) Å, α = γ = 90°, β = 102...
June 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28640230/total-flavonoids-of-drynariae-rhizoma-prevent-bone-loss-induced-by-hindlimb-unloading-in-rats
#13
Shuanghong Song, Ziyang Gao, Xujun Lei, Yinbo Niu, Yuan Zhang, Cuiqin Li, Yi Lu, Zhezhi Wang, Peng Shang
Drynariae Rhizoma is a kidney-tonifying herb that has a long history in clinical practice for the treatment of bone fractures and joint diseases in China. Flavonoids are considered to be its major active ingredients and are reported to ease bone loss in ovariectomized rats. However, the beneficial effects of the total flavonoids of Drynariae Rhizoma on osteoporosis caused by microgravity or mechanical inactivity remain unknown. This study assessed the effects of total Drynariae Rhizoma flavonoids (DRTF, Qihuang, Beijing, China, national medicine permit No...
June 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28640131/paragonimiasis-in-children-in-southwest-china-a-retrospective-case-reports-review-from-2005-to-2016
#14
Zongrong Gong, Ruixue Miao, Min Shu, Yu Zhu, Yang Wen, Qin Guo, Qiong Liao, Chaomin Wan
BACKGROUND: Paragonimiasis infection has no specific symptoms or typical radiologic findings, leading to the possibility of misdiagnosis. Thus, the objective of this study was to analyze clinical and radiological features, and treatment outcome of paragonimiasis in children in Southwest China to improve the awareness of this disease. METHODS: We retrospectively reviewed the records of children diagnosed with paragonimiasis in West China Second University Hospital between 2005 and 2016...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639565/diagnostic-performance-of-the-genotype-mtbdrplus-and-mtbdrsl-assays-to-identify-tuberculosis-drug-resistance-in-eastern-china
#15
Qiao Liu, Guo-Li Li, Cheng Chen, Jian-Ming Wang, Leonardo Martinez, Wei Lu, Li-Mei Zhu
BACKGROUND: The WHO recently has recommended the GenoType MTBDRplus version 1.0 and MTBDRsl version 1.0 assays for widespread use in countries endemic with drug-resistant tuberculosis. Despite this, these assays have rarely been evaluated in China, where the burden of drug-resistant tuberculosis is among the highest globally. METHODS: Mycobacterium tuberculosis clinical isolates were obtained between January 2008 and December 2008. Isolates were tested for drug resistance against rifampicin (RFP) and isoniazid (INH) using the GenoType MTBDRplus assay and drug resistance against ethambutol (EMB), ofloxacin (OFX), and kanamycin (KM) using the Genotype MTBDRsl assay...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28638616/vitamin-d-deficiency-among-newly-diagnosed-tuberculosis-patients-and-their-household-contacts-a-comparative-cross-sectional-study
#16
Meseret Workineh, Biniam Mathewos, Beyene Moges, Adissu Gize, Sisay Getie, Olle Stendahl, Thomas Schon, Ebba Abate
BACKGROUND: Recent studies suggest that the incidence and severity of tuberculosis is associated with low levels of vitamin D. Even though individuals living in Ethiopia have a high exposure to sunlight which is a source of vitamin D, tuberculosis is still one of the major causes of morbidity and mortality in the country. Therefore, this study aimed to determine the prevalence and associated factors of vitamin D deficiency in newly diagnosed tuberculosis patients, household contacts and community controls in Gondar, Ethiopia...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28638420/treatment-delay-and-total-delay-among-pulmonary-tuberculosis-patients-in-the-north-of-iran-application-survival-data-analysis
#17
Jamshid Yazdani-Charati, Mohammad Sadegh Rezai, Afsane Fendereski, Soraya Mohammadi, Nadia Alipour
BACKGROUND: Tuberculosis (TB) remains the leading cause of death among infectious diseases worldwide. Identifying the factors associated with the treatment delay and total delay would be helpful in the prevention of tuberculosis and in reducing the burden on the health care system. The objective of this study was to assess the treatment delay and total delay in TB patients and investigate the factors causing these delays. MATERIALS AND METHODS: This was a longitudinal study conducted in 2009-2015...
2017: Tanaffos
https://www.readbyqxmd.com/read/28636497/size-segregated-particulate-matter-and-its-association-with-respiratory-deposition-doses-among-outdoor-exercisers-in-dhanbad-city-india
#18
Sunil Kumar Gupta, Suresh Pandian Elumalai
Regular exercise improves physiological processes and yields positive health outcomes. However, it is relatively less known that PM exposure during outdoor exercises may increase several respiratory health problems depending on PM levels. In this study, the respiratory deposition doses (RDDs) in head airway (HD), tracheobronchial (TB) and alveolar (AL) regions of various PM size fractions (PM10, PM2.5 and PM1) were estimated in healthy males and females exercisers in urban outdoor and within house premise. The highest RDDs were found for PM during morning hour in winter compared to remaining periods...
June 21, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28635568/additional-value-of-magnetic-resonance-targeted-biopsies-to-standard-transrectal-ultrasound-guided-biopsies-for-detection-of-clinically-significant-prostate-cancer
#19
Catrin von Below, Cecilia Wassberg, Mona Norberg, Anna Tolf, Joel Kullberg, Sam Ladjevardi, Michael Häggman, Anna Bill Axelson, Håkan Ahlström
OBJECTIVE: The aim of this study was to evaluate the additional value of magnetic resonance imaging-targeted biopsy (MRI-TB) to standard transrectal ultrasound-guided biopsy (SB) for detection of clinically significant prostate cancer (PCa). An additional aim was to compare the biopsy results to MRI evaluation using a Likert scale. MATERIALS AND METHODS: Patients with newly diagnosed localized PCa (n = 53) by clinical routine SB were prospectively included. The majority of the patients were scheduled for curative therapy before enrollment...
February 24, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28634479/whole-blood-profiling-of-bacillus-calmette-gu%C3%A3-rin-induced-trained-innate-immunity-in-infants-identifies-epidermal-growth-factor-il-6-platelet-derived-growth-factor-ab-bb-and-natural-killer-cell-activation
#20
Steven G Smith, Johanneke Kleinnijenhuis, Mihai G Netea, Hazel M Dockrell
Vaccination of infants with bacillus Calmette-Guérin (BCG) activates both the innate and adaptive arms of the immune response. The antimycobacterial effects of these responses most likely account for the ability of BCG to protect against childhood forms of tuberculosis (TB). There is also evidence for a heterologous protective effect of BCG vaccination against TB-unrelated mortality in low birth weight infants. A possible mechanism of action of this effect, the induction of trained innate immunity, has been demonstrated when cells from BCG-vaccinated adults are restimulated in vitro with non-related microbial stimuli...
2017: Frontiers in Immunology
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