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https://www.readbyqxmd.com/read/29243779/effects-of-ngx6-expression-on-proliferation-and-invasion-of-nasopharyngeal-carcinoma-cells-and-survival-of-patients
#1
Y-T Wang, X-Y Sun, H Wang, T-T Huang, Y Wang, M-X Yang
OBJECTIVE: To detect the expressions of nasopharyngeal carcinoma-associated gene 6 (NGX6) in nasopharyngeal carcinoma cells and tissues, and to investigate the effects of NGX6 on the proliferation and invasion of nasopharyngeal carcinoma cells and the survival of patients. PATIENTS AND METHODS: The human nasopharyngeal carcinoma cells (HONE1) and immortalized human nasopharyngeal epithelial cells (NP69) were selected and cultured. The mRNA and protein expression levels of NGX6 were detected via quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243157/why-is-a-prone-sleeping-position-dangerous-for-certain-infants
#2
Roger W Byard, Fiona Bright, Robert Vink
The prone (face down) sleeping position is known to be associated with a significantly increased risk of sudden and unexpected death in infancy (sudden infant death syndrome or SIDS), however, the reasons for this are unclear. Suggested mechanisms have involved suffocation from occlusion of the external airways by soft bedding/pillows or from flattening of the nose with backward displacement of the tongue, rebreathing of carbon dioxide, blunting of arousal responses with decreased cardiac responses to auditory stimulation, diaphragmatic splinting or fatigue, lowering of vasomotor tone with tachycardia, nasopharyngeal bacterial overgrowth, overheating, alteration of sleep patterns, compromise of cerebral blood flow and upper airway obstruction from distortion of nasal cartilages...
December 14, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29239125/autofluorescence-and-white-light-imaging-guided-endoscopic-raman-and-diffuse-reflectance-spectroscopy-for-in-vivo-nasopharyngeal-cancer-detection
#3
Duo Lin, Sufang Qiu, Wei Huang, Jianji Pan, Zhihong Xu, Rong Chen, Shangyuan Feng, Guannan Chen, Yongzeng Li, Michael Short, Jianhua Zhao, Yasser Fawzy, Haishan Zeng
Nasopharyngeal cancer (NPC) is an endemic with high incidence in Southern China and Southeast Asia countries. Screening for NPC under conventional white light imaging (WLI) nasopharyngoscope examination remains a great clinical challenge due to its poor sensitivity. Here, we developed an integrated four-modality endoscopy system combining WLI, autofluorescence imaging (AFI), diffuse reflectance spectroscopy (DRS), and Raman spectroscopy (RS) technologies for in vivo endoscopic cancer detection for the first time...
December 14, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29238457/molecular-detection-of-bordetella-holmesii-in-two-infants-with-pertussis-like-syndrome-the-first-report-from-iran
#4
Masoumeh Nakhost Lotfi, Vajiheh Sadat Nikbin, Omid Nasiri, Farzad Badmasti, Fereshteh Shahcheraghi
Background and Objectives: Bordetella holmesii is associated with a pertussis-like respiratory syndrome in healthy individuals and also a rare cause of septicaemia, endocarditis, pneumonia, and septic arthritis, mostly in immunocompromised patients. Culture technique and real-time PCR are 2 methods used to detect Bordetella spp. Materials and Methods: In this study, 435 nasopharyngeal specimens of patients with suspected whooping cough were checked for the presence of B...
August 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29238454/phenotypic-and-genotypic-features-of-first-biofilm-forming-nasopharyngeal-colonized-streptococcus-pneumoniae-isolates
#5
Seyed Fazlollah Mousavi, Bahman Mirzaei, Bahareh Shaghaghi, Pantea Jalali, Tahereh Setayesh, Seyed Hamid Moosavi
Background and Objectives: Designing control and therapeutic policies for antibiotic resistant Streptococcus pneumoniae, which is an important causative agent of several invasive and noninvasive infectious diseases and its carriage rates, has been described as the main target in World Health Organization (WHO). The present study was conducted to determine antibiotic resistance pattern, evaluate biofilm forming ability in S. pneumoniae isolates, and find the genetic relationship between cultured strains...
August 2017: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/29238339/comparing-the-healthy-nose-and-nasopharynx-microbiota-reveals-continuity-as-well-as-niche-specificity
#6
Ilke De Boeck, Stijn Wittouck, Sander Wuyts, Eline F M Oerlemans, Marianne F L van den Broek, Dieter Vandenheuvel, Olivier Vanderveken, Sarah Lebeer
To improve our understanding of upper respiratory tract (URT) diseases and the underlying microbial pathogenesis, a better characterization of the healthy URT microbiome is crucial. In this first large-scale study, we obtained more insight in the URT microbiome of healthy adults. Hereto, we collected paired nasal and nasopharyngeal swabs from 100 healthy participants in a citizen-science project. High-throughput 16S rRNA gene V4 amplicon sequencing was performed and samples were processed using the Divisive Amplicon Denoising Algorithm 2 (DADA2) algorithm...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29237424/p53r2-as-a-novel-prognostic-biomarker-in-nasopharyngeal-carcinoma
#7
Jiewei Chen, Shuman Li, Yongbo Xiao, Xuan Zou, Xinke Zhang, Mingshu Zhu, Muyan Cai, Dan Xie
BACKGROUND: p53R2 is a target of p53 gene, which is essential for DNA repair, mitochondrial DNA synthesis, protection against oxidative stress, chromosomal instability, chronic inflammation and tumorigenesis. This study is aimed to investigate the expression of ribonucleotide reductase (RR) subunit p53R2 in nasopharyngeal carcinoma and its significance in the prognosis. METHODS: The expression levels of p53R2 in 201 patients with NPC were examined by immunohistochemical assay...
December 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29237419/performance-of-the-alere-i-rsv-assay-for-point-of-care-detection-of-respiratory-syncytial-virus-in-children
#8
Sarah Valerie Schnee, Johannes Pfeil, Clara Marlene Ihling, Julia Tabatabai, Paul Schnitzler
BACKGROUND: Respiratory syncytial virus (RSV) is the most important cause of severe acute respiratory tract infection in young children. Alere i RSV is a novel molecular rapid test which identifies respiratory syncytial virus in less than 13 min. METHODS: We evaluated the clinical performance of the Alere i RSV assay in a pediatric point-of-care setting during winter season 2016 / 2017. Test results from 518 nasopharyngeal swab samples were compared to a real-time reverse transcription PCR reference standard...
December 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29237402/prevalence-and-serotype-distribution-of-nasopharyngeal-carriage-of-streptococcus-pneumoniae-in-china-a-meta-analysis
#9
Lin Wang, Jinjian Fu, Zhuoxin Liang, Jichang Chen
BACKGROUND: To explore the overall prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae(S. pneumoniae) among healthy children. METHODS: A search for pneumococcal nasopharyngeal carriage studies including children published up to July 31th, 2016 was conducted to describe carriage in China. The review also describes antibiotic resistance in and serotypes of S. pneumoniae and assesses the impact of vaccination on carriage in this region...
December 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29237362/de-novo-malignancies-after-liver-transplantation-a-single-institution-experience
#10
Tufan Egeli, Tarkan Unek, Mucahit Ozbilgin, Cihan Agalar, Serhan Derici, Mesut Akarsu, Ilkay Tugba Unek, Murat Aysin, Aylin Bacakoglu, Ibrahim Astarcıoglu
OBJECTIVES: Our objective was to analyze characteristics, risk factors, and incidence of de novo malignancies after liver transplant. MATERIALS AND METHODS: The hospital records of 557 patients who underwent liver transplant were analyzed from the point of de novo malignancy development. We evaluated the demographic features and survival of these patients retrospectively. RESULTS: The research covered 429 patients, 9 (2%) of whom developed de novo malignancy...
December 14, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29236943/a-randomized-trial-of-induction-docetaxel-cisplatin-5fu-followed-by-concomitant-cisplatin-rt-versus-concomitant-cisplatin-rt-in-nasopharyngeal-carcinoma-gortec-2006-02
#11
M Frikha, A Auperin, Y Tao, F Elloumi, N Toumi, P Blanchard, P Lang, S Sun, S Racadot, J Thariat, M Alfonsi, C Tuchais, A Cornely, A Moussa, J Guigay, J Daoud, J Bourhis
Background: concomitant CT-RT is a standard of care in locally advanced nasopharyngeal carcinoma (NPC) and a role for induction CT is not established. Methods: patients with locally advanced NPC, WHO type 2 or 3, were randomized to induction TPF plus concomitant cisplatin -RT or concomitant cisplatin -RT alone. The TPF regimen consisted of 3 cycles of Docetaxel 75 mg/m2 Day 1; cisplatin 75 mg/m2 Day 1; 5FU 750 mg/m2/d Day 1-5. RT consisted of 70 Gy in 7 weeks plus concomitant cisplatin 40 mg/m2 weekly...
December 11, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29236265/nasopharyngeal-papillary-adenocarcinoma
#12
Lester D Thompson
No abstract text is available yet for this article.
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29235932/retrospective-study-of-the-presentation-diagnosis-and-management-of-16-cats-with-otitis-media-not-due-to-nasopharyngeal-polyp
#13
Nicola Swales, Aiden Foster, Natalie Barnard
Objectives The aim of this study was to analyse retrospectively cats diagnosed with otitis media (OM) not due to nasopharyngeal polyp, and to review the clinical outcome with surgical and medical management. Methods Patient records were searched for cats diagnosed with OM. The diagnosis of OM was based on the presence of clinical signs, including neurological signs, respiratory signs and signs of otitis externa, and on the basis of evidence of thickened or irregular bullae walls, or the presence of fluid within the tympanic cavity; in those that had diagnostic imaging...
December 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29234119/non-malignant-epithelial-cells-preferentially-proliferate-from-nasopharyngeal-carcinoma-biopsy-cultured-under-conditionally-reprogrammed-conditions
#14
Fenggang Yu, Yanan Lu, Lin Tao, Yan-Yi Jiang, De-Chen Lin, Lingzhi Wang, Fredrik Petersson, Hironori Yoshiyama, Phillip H Koeffler, Boon-Cher Goh, Kwok Seng Loh
Nasopharyngeal carcinoma (NPC) is an invasive cancer with particularly high incidence in Southern China and Southeast Asia. The study of NPC is greatly hampered by the lack of reliable cell lines due to the loss of EBV genome and HeLa cell contamination. Conditional reprogramming (CR) cell culture technique has been reported for rapid and efficient establishment of patient-derived normal and tumor cell cultures. The purpose of this study was to assess this method to culture NPC patient-derived primary tumor cells...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233015/the-benefits-of-folic-acid-modified-gold-nanoparticles-in-ct-based-molecular-imaging-radiation-dose-reduction-and-image-contrast-enhancement
#15
Jaber Beik, Maryam Jafariyan, Alireza Montazerabadi, Ali Ghadimi-Daresajini, Parastoo Tarighi, Alireza Mahmoudabadi, Habib Ghaznavi, Ali Shakeri-Zadeh
X-ray computed tomography (CT) requires an optimal compromise between image quality and patient dose. While high image quality is an important requirement in CT, the radiation dose must be kept minimal to protect the patients from ionizing radiation-associated risks. The use of probes based on gold nanoparticles (AuNPs) along with active targeting ligands for specific recognition of cancer cells may be one of the balanced solutions. Herein, we report the effect of folic acid (FA)-modified AuNP as a targeted nanoprobe on the contrast enhancement of CT images as well as its potential for patient dose reduction...
December 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29232879/the-alteration-of-nasopharyngeal-and-oropharyngeal-microbiota-in-children-with-mpp-and-non-mpp
#16
Zhiwei Lu, Wenkui Dai, Yanhong Liu, Qian Zhou, Heping Wang, Dongfang Li, Zhenyu Yang, Yinhu Li, Gan Xie, Shuaicheng Li, Yuejie Zheng
Background: In recent years, the morbidity of Mycoplasma pneumoniae pneumonia (MPP) has increased significantly in China. A growing number of studies indicate that imbalanced respiratory microbiota is associated with various respiratory diseases. Methods: We enrolled 119 children, including 60 pneumonia patients and 59 healthy children. Nasopharyngeal (NP) and oropharyngeal (OP) sampling was performed for 16S ribosomal RNA (16S rRNA) gene analysis of all children. Sputum and OP swabs were obtained from patients for pathogen detection...
December 11, 2017: Genes
https://www.readbyqxmd.com/read/29230817/ebv-encoded-mirnas-target-atm-mediated-response-in-nasopharyngeal-carcinoma
#17
Raymond W-M Lung, Pok-Man Hau, Ken H-O Yu, Kevin Y Yip, Joanna H-M Tong, W-P Chak, Anthony W-H Chan, Ka-Hei Lam, Angela K-F Lo, Edith K-Y Tin, Shuk-Ling Chau, Jesse C-S Pang, Johnny S-H Kwan, Pierre Busson, Lawrence S Young, Lee-Fah Yap, Sai-Wah Tsao, Ka-Fai To, Kwok-Wai Lo
Nasopharyngeal carcinoma (NPC) is a highly invasive epithelial malignancy that is prevalent in southern China and Southeast Asia. It is consistently associated with latent Epstein-Barr virus (EBV) infection. In NPC, miR-BARTs, the EBV-encoded miRNAs derived from BamH1-A rightward transcripts are abundantly expressed and contribute to cancer development by targeting various cellular and viral genes. In this study, we establish a comprehensive transcriptional profile of EBV-encoded miRNAs in a panel of NPC patient-derived xenografts and an EBV-positive NPC cell line by small RNA sequencing...
December 12, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29229103/effect-of-budesonide-formoterol-pressurized-metered-dose-inhaler-on-exacerbations-versus-formoterol-in-chronic-obstructive-pulmonary-disease-the-6-month-randomized-rise-revealing-the-impact-of-symbicort-in-reducing-exacerbations-in-copd-study
#18
Gary T Ferguson, Donald P Tashkin, Tor Skärby, Carin Jorup, Kristina Sandin, Michael Greenwood, Kristine Pemberton, Frank Trudo
BACKGROUND: Prevention of exacerbations is a primary goal for chronic obstructive pulmonary disease (COPD) therapy. This randomized, double-blind, double-dummy, parallel-group, multicenter study evaluated the effect of budesonide/formoterol pressurized metered-dose inhaler (pMDI) versus formoterol dry powder inhaler (DPI) on reducing COPD exacerbations. METHODS: 1219 patients aged ≥40 years with moderate-to-very-severe COPD (per lung function) and a history of ≥1 COPD exacerbation received budesonide/formoterol pMDI 320/9 μg twice daily (BID) during a 4-week run-in...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228613/the-incidence-and-prognosis-of-nasopharyngeal-carcinoma-patients-with-family-history
#19
Yansu Wang, Chunying Shen, Xueguan Lu, Chaosu Hu
Purpose: Epidemiological data showed that nasopharyngeal carcinoma (NPC) was a regional malignancy. It suggested that genetic factor may play an important role in tumorigenesis of NPC. The aim was to investigate the incidence and the prognosis of NPC patients with family history. Methods: The clinical data of patients with NPC treated in Fudan University Shanghai Cancer Center from January 2008 to December 2012 were reviewed, and the patients with family history were selected...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228572/gemcitabine-cisplatin-induction-chemotherapy-before-concurrent-chemotherapy-and-intensity-modulated-radiotherapy-improves-outcomes-for-locoregionally-advanced-nasopharyngeal-carcinoma
#20
Wang Fangzheng, Sun Quanquan, Jiang Chuner, Wang Lei, Yan Fengqin, Ye Zhimin, Liu Tongxin, Xu Min, Wu Peng, Jiang Haitao, Rihito Aizawa, Masoto Sakamoto, Wang Yuezhen, Fu Zhenfu
Addition of induction chemotherapy (IC) to concurrent chemoradiotherapy (CC) is an encouraging first-line treatment strategy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We evaluated the clinical efficacy and toxicity of addition of gemcitabine plus cisplatin (GP) IC to intensity-modulated radiotherapy (IMRT) and CC for patients with locoregionally advanced NPC. At a median follow-up duration of 48 months (10-59 months), 4-year local relapse-free survival (LRFS) was 86.9%, regional relapse-free survival (RRFS) was 90...
November 14, 2017: Oncotarget
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