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https://www.readbyqxmd.com/read/28525724/interaction-between-mir-572-and-ppp2r2c-and-their-effects-on-proliferation-migration-and-invasion-of-nasopharyngeal-carcinoma-npc-cells
#1
Lei Yan, Kerui Cai, Jun Liang, Haifeng Liu, Yang Liu, Jinqiu Gui
We investigated the regulation of miR-572 on PPP2R2C and studied their effects on proliferation, migration as well as invasion of nasopharyngeal carcinoma (NPC) cells. NPC tissues and normal tissues were collected, and the expressions of miR-572 and PPP2R2C were detected by RT-PCR. And Western blot was applied to detect the expression of PPP2R2C protein. The target relationship between miR-572 and PPP2R2C was confirmed by dual luciferase reporter gene assay. MTT assay and flow cytometry was applied to investigate the viability and apoptosis of NPC cells...
May 19, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28525383/histogram-analysis-of-diffusion-kurtosis-imaging-of-nasopharyngeal-carcinoma-correlation-between-quantitative-parameters-and-clinical-stage
#2
Xiao-Quan Xu, Gao Ma, Yan-Jun Wang, Hao Hu, Guo-Yi Su, Hai-Bin Shi, Fei-Yun Wu
PURPOSE: To evaluate the correlation between histogram parameters derived from diffusion-kurtosis (DK) imaging and the clinical stage of nasopharyngeal carcinoma (NPC). RESULTS: High T-stage (T3/4) NPC showed significantly higher Kapp-mean (P = 0.018), Kapp-median (P = 0.029) and Kapp-90th (P = 0.003) than low T-stage (T1/2) NPC. High N-stage NPC (N2/3) showed significantly lower Dapp-mean (P = 0.002), Dapp-median (P = 0.002) and Dapp-10th (P < 0.001) than low N-stage NPC (N0/1)...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28522701/genome-sequence-of-human-papillomavirus-23-strain-hpv-23-lancaster-2015
#3
Kate V Atkinson, Lisa A Bishop, Glenn Rhodes, Nicolas Salez, Neil R McEwan, Matthew J Hegarty, Julie Robey, Nicola Harding, Simon Wetherell, Robert M Lauder, Roger W Pickup, Mark Wilkinson, Derek Gatherer
The genome of human papillomavirus type 23 (HPV-23; family Papillomaviridae, genus Betapapillomavirus, species Betapapillomavirus 2, type 23) was assembled by deep sequencing from nasopharyngeal swabs. The assembled genome is 2.7% divergent over its full length from the single complete genome of HPV-23 in GenBank (accession no. U31781). We named the strain HPV-23/Lancaster/2015.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28518131/incidence-of-respiratory-viral-infection-in-infants-with-respiratory-symptoms-evaluated-for-late-onset-sepsis
#4
J B Cerone, R P Santos, D Tristram, D M Lamson, K A Stellrecht, K St George, M J Horgan, A Rios
OBJECTIVE: To determine the frequency, etiology and impact of respiratory viral infection (RVI) on infants evaluated for late-onset sepsis (LOS), defined as sepsis occurring >72 h of life, in the neonatal intensive care unit. STUDY DESIGN: Prospective observational study conducted from 6 March 2014 to 3 May 2016 on infants evaluated for LOS. PCR viral panel performed on nasopharyngeal specimens among infants with clinical suspicion for RVI. Sequence analysis was performed to determine viral subtypes...
May 18, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28516960/clinicopathologic-idiosyncrasies-of-nasopharyngeal-cancer-in-a-moderate-risk-mediterranean-region
#5
K Kourelis, T Stergiou, A Papadas, T Kourelis, E Petta, T Papadas
Cancer of the nasopharynx displays an unparalleled skewness of its epidemiologic, pathogenic and clinico-prognostic characteristics depending on the geographic location. Between the endemic and sporadic forms, which occur in Southeastern Asia and Northern America, respectively, intermediate incidence is noted around the Mediterranean. This study describes the patterns of the disease affecting the population of Western Greece. The records of 70 patients with nasopharyngeal cancer diagnosed in a single institution between 1994-2014 were retrospectively reviewed...
June 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28516200/respiratory-viral-infections-are-underdiagnosed-in-patients-with-suspected-sepsis
#6
L R Ljungström, G Jacobsson, B E B Claesson, R Andersson, H Enroth
The study aim was to investigate the prevalence and clinical relevance of viral findings by multiplex PCR from the nasopharynx of clinically septic patients during a winter season. During 11 weeks of the influenza epidemic period in January-March 2012, consecutive adult patients suspected to be septic (n = 432) were analyzed with cultures from blood and nasopharynx plus multiplex PCR for respiratory viruses on the nasopharyngeal specimen. The results were compared with those from microbiology analyses ordered as part of standard care...
May 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28515352/intensity-modulated-radiotherapy-provides-better-quality-of-life-than-two-dimensional-conventional-radiotherapy-for-patients-with-stage-ii-nasopharyngeal-carcinoma
#7
Xin-Bin Pan, Shi-Ting Huang, Kai-Hua Chen, Yan-Ming Jiang, Jia-Lin Ma, Song Qu, Ling Li, Long Chen, Xiao-Dong Zhu
Two-dimensional conventional radiotherapy (2D-CRT) and intensity-modulated radiotherapy (IMRT) are effective for control of nasopharyngeal carcinoma (NPC). The purpose of this study was to compare the quality of life (QoL) of stage II NPC patients treated with 2D-CRT versus IMRT. We conducted a cross-sectional study of 106 patients with stage II NPC treated with 2D-CRT (n = 47) versus IMRT (n = 59) between June 2008 and June 2013. For all subjects, disease-free survival was more than 3 years. QoL was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) questions and the Head and Neck 35 (EORTC QLQ-H&N35) questions...
May 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28515347/mir-187-overexpression-inhibits-cervical-cancer-progression-by-targeting-hpv16-e6
#8
Mao Lin, Xiang Xue, Shu-Zhen Liang, Yin-Xiong Li, You-Yong Lv, Li-Hua He, Ke-Cheng Xu, Ji-Bing Chen, Li-Zhi Niu
Aberrantly expressed microRNAs contribute to the initiation and progression of human cancer. MiRNA-187 has been reported in nasopharyngeal, renal, pancreatic, prostate, and esophageal cancer, and acts as a tumor suppressor or oncogene. However, the underlying function of miRNA-187 in cervical cancer remains largely unexplored. In the present study, we demonstrated significantly miRNA-187 down-regulation in cervical cancer tissues and cell lines compared to their normal counterparts. Kaplan-Meier analysis revealed that decreased miRNA-187 was closely associated with shorter overall survival and relapse-free survival...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28515295/natural-variation-of-epstein-barr-virus-genes-proteins-and-pri-mirna-revised
#9
Samantha Correia, Anne Palser, Claudio Elgueta Karstegl, Jaap M Middeldorp, Octavia Ramayanti, Jeffrey I Cohen, Allan Hildesheim, Maria Dolores Fellner, Joelle Wiels, Robert E White, Paul Kellam, Paul J Farrell
Viral gene sequences from an enlarged set of about 200 Epstein-Barr virus (EBV) strains including many primary isolates have been used to investigate variation in key viral genetic regions, particularly LMP1, Zp, gp350, EBNA1 and the BART miRNA cluster 2. Determination of type 1 and type 2 EBV in saliva samples from people from a wide range of geographic and ethnic backgrounds demonstrates a small percentage of healthy white Caucasian British people carrying predominantly type 2 EBV. Linkage of Zp and gp350 variants to type 2 EBV is likely to be due to their genes being adjacent to the EBNA3 locus, which is one of the major determinants of the type 1/type 2 distinction...
May 17, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28514666/a-temporal-proteomic-map-of-epstein-barr-virus-lytic-replication-in-b-cells
#10
Ina Ersing, Luis Nobre, Liang Wei Wang, Lior Soday, Yijie Ma, Joao A Paulo, Yohei Narita, Camille W Ashbaugh, Chang Jiang, Nicholas E Grayson, Elliott Kieff, Steven P Gygi, Michael P Weekes, Benjamin E Gewurz
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus-host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection. We quantified profiles of >8,000 cellular and 69 EBV proteins, including >500 plasma membrane proteins, providing temporal views of the lytic B cell proteome and EBV virome...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28514301/unusual-axillary-metastasis-of-recurrent-nasopharyngeal-cancer-a-case-report
#11
Deng-Yu Kuo, Min-Hsiang Chang, Shan-Ying Wang, Pei-Ying Hsieh, Pei-Wei Shueng
RATIONALE: Nasopharyngeal carcinoma (NPC) has a high propensity of metastasis. The most commonly described sites of distant metastasis are the bones, lungs, and liver, whereas axillary metastasis is seldom reported. PATIENT CONCERNS: We hereby present the case of a 66-year-old man with NPC, cT2N2M0, at diagnosis. He had completed chemoradiotherapy and been disease-free for 7 years. DIAGNOSES: After that period, late recurrence in the form of a solitary axillary lymph node metastasis was detected and confirmed by core-needle biopsy...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28514288/bordetella-parapertussis-outbreak-in-southeastern-minnesota-and-the-united-states-2014
#12
Vytas P Karalius, Stefanea L Rucinski, Jayawant N Mandrekar, Robin Patel
Whooping cough is traditionally ascribed to Bordetella pertussis; however, Bordetella parapertussis can cause a similar clinical syndrome. This study describes an outbreak of B. parapertussis in Southeastern Minnesota and the United States (US) in 2014. This was a retrospective analysis of Mayo Clinic and Mayo Medical Laboratories patients who tested positive for B. parapertussis from 2012 to 2014. The medical records of Mayo Clinic patients who tested positive in 2014 were reviewed for demographic information, presenting symptoms, disease course, and vaccination history...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28512118/epstein-barr-virus-encoded-lmp2a-stimulates-migration-of-nasopharyngeal-carcinoma-cells-via-egfr-ca-2-calpain-itg%C3%AE-4-axis
#13
Jiezhen Liang, Shixing Zheng, Xue Xiao, Jiazhang Wei, Zhe Zhang, Ingemar Ernberg, Liudmila Matskova, Guangwu Huang, Xiaoying Zhou
Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) promotes the motility of nasopharyngeal carcinoma (NPC) cells. Previously, we have shown that the localization of integrin β4 (ITGβ4) was regulated by LMP2A, with ITGβ4 concentrated at the cellular protrusions in LMP2A expressing NPC cells. In the present study, we aim to further investigate mechanisms involved in this process and its contribution to cell motility. We show that expression of LMP2A was correlated with increased EGFR activation, elevated levels of intracellular Ca(2+), calpain activation and accelerated cleavage of ITGβ4...
May 16, 2017: Biology Open
https://www.readbyqxmd.com/read/28511667/epidemiology-of-pertussis-in-casablanca-morocco-contribution-of-conventional-and-molecular-diagnosis-tools
#14
Khalid Katfy, Nicole Guiso, Idrissa Diawara, Khalid Zerouali, Bouchra Slaoui, Zineb Jouhadi, Abdelhadi Zineddine, Houria Belabbes, Naima Elmdaghri
BACKGROUND: Pertussis, a vaccine preventable disease, is still responsible of significant morbidity and mortality around the world, mostly in newborns. The aim of the present study was (1) to introduce pertussis surveillance in the major pediatric hospital of Casablanca (2) to analyze the prevalence of pertussis among children under 14 years of age and their entourage in Casablanca, Morocco. METHODS: This is a prospective and non-case controlled study, including children suspected of Pertussis admitted at the Abderrahim Harouchi Pediatric Hospital in Casablanca, from January 2013 to June 2015...
May 16, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28511585/three-phase-adaptive-radiation-therapy-for-patients-with-nasopharyngeal-carcinoma-undergoing-intensity-modulated-radiation-therapy-dosimetric-analysis
#15
Shan Deng, Xu Liu, Heming Lu, Huixian Huang, Liuyang Shu, Hailan Jiang, Jinjian Cheng, Luxing Peng, Qiang Pang, Junzhao Gu, Jian Qin, Zhiping Lu, Ying Mo, Danling Wu, Yinglin Wei
Patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy may experience significant anatomic changes throughout the entire treatment course, and adaptive radiation therapy may be necessary to maintain optimal dose delivered both to the targets and to the critical structures. The timing of adaptive radiation therapy, however, is largely unknown. This study was to evaluate the dosimetric benefits of a 3-phase adaptive radiation therapy technique for nasopharyngeal carcinoma. Twenty patients with nasopharyngeal carcinoma treated with intensity-modulated radiation therapy were recruited prospectively...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28509567/early-evaluation-of-radiation-induced-parotid-damage-with-diffusion-kurtosis-imaging-a-preliminary-study
#16
Nan Zhou, Weibo Chen, Xia Pan, Jian He, Jing Yan, Zhengyang Zhou, Xiaofeng Yang
Background Radiation-induced parotid gland damage is a common complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC), which always causes xerostomia, dysphagia, dental caries, and even sleep disorders. Early evaluation of radiation-induced parotid damage is required to facilitate early interventions. Purpose To early-evaluate radiation-induced parotid damage using diffusion kurtosis imaging (DKI) in patients with NPC undergoing RT. Material and Methods Thirty-two patients with NPC underwent DKI for parotid glands pre-RT (two weeks before RT), mid-RT (five weeks after RT began), and post-RT (four weeks after RT)...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28508272/nasopharyngeal-angiofibroma-a-clinical-histopathological-and-immunohistochemical-study-of-42-cases-with-emphasis-on-stromal-features
#17
Celeste Sánchez-Romero, Roman Carlos, Juan Pablo Díaz Molina, Lester D R Thompson, Oslei Paes de Almeida, Alicia Rumayor Piña
Nasopharyngeal angiofibroma is a benign but aggressive tumor of unknown etiology, typically occurring in adolescent males. It is described as a rare neoplasm; however, the prevalence seems to have geographic differences. All cases referred to our head and neck clinical and pathology service were reviewed. Most of the patients presented at an advanced stage. The clinical and radiographic features are presented and discussed. Histologically, the tumor shows a highly vascular fibrous proliferation with characteristic plump, angulated and stellate cells, categorized as fibroblasts...
May 15, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28507857/greater-omental-lymph-node-flap-for-upper-limb-lymphedema-with-lymph-nodes-depleted-patient
#18
Yu-Ying Chu, Robert J Allen, Ting-Jung Wu, Ming-Huei Cheng
BACKGROUND: The greater omentum is supplied by the right, middle, and left omental arteries, which arise from the right and left gastroepiploic arteries. All or part of the greater omentum can be harvested based on this blood supply for free tissue transfer. It has stimulated new interest in its use as the donor site in the treatment of lymphedema. For patients who have failed other management options or have limited peripheral lymph node donor sites, the greater omental lymph node flap may offer the best chance for lymphedema treatment...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28507812/a-barf1-specific-mab-as-a-new-immunotherapeutic-tool-for-the-management-of-ebv-related-tumors
#19
Riccardo Turrini, Anna Merlo, Debora Martorelli, Damiana Antonia Faè, Roberta Sommaggio, Isabella Monia Montagner, Vito Barbieri, Oriano Marin, Paola Zanovello, Riccardo Dolcetti, Antonio Rosato
The use of monoclonal antibodies (mAb) for the diagnosis and treatment of malignancies is acquiring an increasing clinical importance, thanks to their specificity, efficacy and relative easiness of use. However, in the context of Epstein-Barr virus (EBV)-related malignancies, only cancers of B-cell origin can benefit from therapeutic mAb targeting specific B-cell lineage antigens. To overcome this limitation, we generated a new mAb specific for BARF1, an EBV-encoded protein with transforming and immune-modulating properties...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28507246/the-pneumococcal-type-1-pilus-genes-are-thermoregulated-and-are-repressed-by-a-member-of-the-snf2-protein-family
#20
Alan Basset, Muriel Herd, Raecliffe Daly, Simon L Dove, Richard Malley
In Streptococcus pneumoniae, the type 1 pilus is involved in many steps of pathogenesis, including adherence to epithelial cells, mediation of inflammation, escape from macrophages, and the formation of biofilms. The type 1 pilus genes are expressed in a bistable fashion with cells switching between ON and OFF expression states. Bistable expression of these genes is due to their control by RlrA, a positive regulator subject to control by a positive feedback loop. The type 1 pilus genes are also thought to be negatively regulated by a large number of repressors...
May 15, 2017: Journal of Bacteriology
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