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https://www.readbyqxmd.com/read/27914687/braf-nras-kit-tert-gnaq-gna11-mutation-profile-analysis-of-head-and-neck-mucosal-melanomas-a-study-of-42-cases
#1
Şule Öztürk Sari, İsmaİl Yilmaz, Orhun Çiğ Taşkin, Gİzem Narli, Fatma Şen, Şenol Çomoğlu, Pinar Firat, Bİlge Bİlgİç, Dİlek Yilmazbayhan, Yasemİn Özlük, Nesİmİ Büyükbabanİ
Head and neck mucosal melanoma (HNMuM), which occurs mostly in the sinonasal and oral cavity, constitutes less than 1% of all malignant melanomas. Treatment options fail to improve the prognosis of this aggressive tumour that has low overall survival rates. Thus, development of new targeted therapies is essential. Unfortunately, limited data exist regarding their molecular profile. BRAF, NRAS, KIT, TERT and GNAQ/GNA11 oncogene mutations were investigated in 42 HNMuMs (28 sinonasal, 13 oral, 1 nasopharyngeal)...
November 30, 2016: Pathology
https://www.readbyqxmd.com/read/27912986/a-phase-iii-observer-blind-randomized-controlled-study-to-evaluate-the-immune-response-and-the-correlation-with-nasopharyngeal-carriage-after-immunization-of-university-students-with-a-quadrivalent-meningococcal-acwy-glycoconjugate-or-serogroup-b-meningococcal
#2
Robert C Read, Peter Dull, Xilian Bai, Kate Nolan, Jamie Findlow, Rohit Bazaz, Annett Kleinschmidt, Maggie McCarthy, Huajun Wang, Daniela Toneatto, Ray Borrow
BACKGROUND: University students have high rates of pharyngeal carriage of Neisseria meningitidis. Interruption of carriage acquisition is an important mechanism of vaccines for inducing herd protection. 4CMenB and MenACWY-CRM vaccines have been shown to be immunogenic against meningococcal serogroups B and ACWY respectively in younger age groups, and also to elicit a modest impact on meningococcal carriage in vaccinated students. However, vaccine responses in university students and the impact of serum bactericidal antibody (SBA) titers on meningococcal carriage are undetermined...
November 29, 2016: Vaccine
https://www.readbyqxmd.com/read/27911864/effect-of-interrupted-time-during-intensity-modulated-radiation-therapy-on-survival-outcomes-in-patients-with-nasopharyngeal-cancer
#3
Guo-Zeng Xu, Ling Li, Xiao-Dong Zhu
OBJECTIVE: To evaluate the influence of interrupted time (IT) during intensity-modulated radiotherapy (IMRT) on survival outcomes in patients with nasopharyngeal cancer (NPC). MATERIALS AND METHODS: 515 NPC patients receiving IMRT between January 2007 and December 2011 were retrospectively reviewed. The association of IT with loco-regional failure-free survival (LRFS), progression free survival (PFS) and overall survival (OS) was assessed by univariate and multivariate analysis...
November 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27909446/functional-toxicogenomic-profiling-expands-insight-into-modulators-of-formaldehyde-toxicity-in-yeast
#4
Matthew North, Brandon D Gaytán, Carlos Romero, Vanessa Y De La Rosa, Alex Loguinov, Martyn T Smith, Luoping Zhang, Chris D Vulpe
Formaldehyde (FA) is a commercially important chemical with numerous and diverse uses. Accordingly, occupational and environmental exposure to FA is prevalent worldwide. Various adverse effects, including nasopharyngeal, sinonasal, and lymphohematopoietic cancers, have been linked to FA exposure, prompting designation of FA as a human carcinogen by U.S. and international scientific entities. Although the mechanism(s) of FA toxicity have been well studied, additional insight is needed in regard to the genetic requirements for FA tolerance...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27907156/increased-nasopharyngeal-density-and-concurrent-carriage-of-streptococcus-pneumoniae-haemophilus-influenzae-and-moraxella-catarrhalis-are-associated-with-pneumonia-in-febrile-children
#5
Sopio Chochua, Valérie D'Acremont, Christiane Hanke, David Alfa, Joshua Shak, Mary Kilowoko, Esther Kyungu, Laurent Kaiser, Blaise Genton, Keith P Klugman, Jorge E Vidal
BACKGROUND: We assessed nasopharyngeal (NP) carriage of five pathogens in febrile children with and without acute respiratory infection (ARI) of the upper (URTI) or lower tract, attending health facilities in Tanzania. METHODS: NP swabs collected from children (N = 960) aged 2 months to 10 years, and with a temperature ≥38°C, were utilized to quantify bacterial density of S. pneumoniae (Sp), H. influenzae (Hi), M. catarrhalis (Mc), S. aureus (Sa), and N. meningitidis (Nm)...
2016: PloS One
https://www.readbyqxmd.com/read/27906102/radiation-induced-osteosarcoma-of-the%C3%A2-skull-base-after-radiation-therapy-in-a-patient-with-nasopharyngeal-carcinoma-a%C3%A2-case-report-and-review-of-the%C3%A2-literature
#6
Yassine Echchikhi, Hasna Loughlimi, Asmae Touil, Tayeb Kebdani, Noureddine Benjaafar
BACKGROUND: Radiation-induced osteosarcomas are a recognized complication of radiation therapy. Owing to the fact that it is rare, publications on radiation-induced osteosarcoma of the skull base are limited to a small series and some case reports. CASE PRESENTATION: We describe a rare case of a patient with a skull base radiation-induced osteosarcoma treated 11 years before with ionizing radiation for an undifferentiated carcinoma of the nasopharynx. The patient was treated with chemotherapy alone, but he died after the third cycle...
December 1, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27905621/-parechovirus-as-etiologic-agent-of-meningitis-and-or-sepsis-like-illness-in-infants
#7
Valentina Gutiérrez, Constanza Martínez-Valdebenito, Luisa Montecinos, Romina Alarcón, Constanza Gárate, Marcela Ferrés
INTRODUCTION: Human parechovirus (HPeV) belongs to the Picornaviridae family and has been described in viral meningoencephalitis and sepsis like illness in infants. Until now, 16 genotypes have been recognized, the most common are HPEV 1, 2 and 3; type 3 is most severe. AIMS: To estimate the frequency of HPEV etiology in viral meningoencephalitis and sepsis in infants and characterize clinical and molecular aspects of infection. METHODS: Between October 2013 and March 2015 we collected CSF samples, plasma, nasopharyngeal swabs and/or stools of patients younger than two years with suspected sepsis and/or viral meningitis...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27904660/comparison-of-mri-ct-and-18f-fdg-pet-ct-in-the-diagnosis-of-local-and-metastatic-of-nasopharyngeal-carcinomas-an-updated-meta-analysis-of-clinical-studies
#8
Wang-Sheng Chen, Jian-Jun Li, Lan Hong, Zeng-Bao Xing, Fen Wang, Chang-Qing Li
BACKGROUND: A meta-analysis was conducted to evaluate the accuracy of MRI, CT and FDG PET/CT in TNM stage of nasopharyngeal carcinoma patients (NPC). METHODS: Through a search of studies from 1996 to April 2015, pooled estimated sensitivity, specificity, pooled diagnostic odds ratio (DOR), summary receiver operating characteristic (SROC) curves and Q*-index were calculated. RESULTS: Totally 23 studies were included for analysis. In T stage, the pooled sensitivity, specificity, DOR and SROC of MRI were 0...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27904520/a-diagnostic-one-step-real-time-reverse-transcription-polymerase-chain-reaction-method-for-accurate-detection-of-influenza-virus-type-a
#9
Mohammad Amin Behzadi, Mazyar Ziyaeyan, Abdolvahab Alborzi
INTRODUCTION: Influenza A is known as a public health concern worldwide. In this study, a novel one-step real-time reverse transcription polymerase chain reaction (rtRT-PCR) assay was designed and optimized for the detection of influenza A viruses. MATERIAL AND METHODS: The primers and probe were designed based on the analysis of 90 matrix nucleotide sequence data of influenza type A subtypes from the GenBank database of the National Center for Biotechnology Information (NCBI)...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904451/the-ratio-of-weight-loss-to-planning-target-volume-significantly-impacts-setup-errors-in-nasopharyngeal-cancer-patients-undergoing-helical-tomotherapy-with-daily-megavoltage-computed-tomography
#10
Wei-Hsien Hou, Chun-Wei Wang, Chiao-Ling Tsai, Feng-Ming Hsu, Jason Chia-Hsien Cheng
BACKGROUND: Changes in head and neck anatomy during radiation therapy (RT) produce setup uncertainties of nasopharyngeal cancer (NPC) irradiation. We retrospectively analyzed image guidance data to identify clinical predictors of setup errors. PATIENTS AND METHODS: The data of 217 NPC patients undergoing definitive RT on a helical tomotherapy (HT) unit were analyzed. Factors including tumor stage, body mass index, weight loss, and planning target volume (PTV) were assessed as predictors of daily megavoltage computed tomography (MVCT) setup displacements, which were automatically registered using software...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27903461/clinical-characteristics-and-outcome-of-respiratory-syncytial-virus-infection-among-adults-hospitalized-with-influenza-like-illness-in-france
#11
Paul Loubet, Nezha Lenzi, Martine Valette, Vincent Foulongne, Anne Krivine, Nadhira Houhou, Gisele Lagathu, Sylvie Rogez, Sophie Alain, Xavier Duval, Florence Galtier, Deborah Postil, Pierre Tattevin, Philippe Vanhems, Fabrice Carrat, Bruno Lina, Odile Launay
OBJECTIVES: The aim of this study was to analyze characteristics and outcome of RSV infection in adults hospitalized with influenza-like illness (ILI). METHODS: Patients hospitalized with ILI were included in this prospective, multicenter study carried out in six French hospitals during three consecutive influenza seasons (2012-2015). RSV and other respiratory viruses were detected by multiplex PCR in nasopharyngeal swabs. Risk factors for RSV infection were identified by backward stepwise logistic regression analysis...
November 26, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27902742/chloroquine-sensitizes-nasopharyngeal-carcinoma-cells-but-not-nasoepithelial-cells-to-irradiation-by-blocking-autophagy
#12
Anna Makowska, Michael Eble, Kirsten Prescher, Mareike Hoß, Udo Kontny
BACKGROUND: Treatment of nasopharyngeal carcinoma requires the application of high dosages of radiation, leading to severe long-term complications in the majority of patients. Sensitizing tumor cells to radiation could be a means to increase the therapeutic window of radiation. Nasopharyngeal carcinoma cells display alterations in autophagy and blockade of autophagy has been shown to sensitize them against chemotherapy. METHODS: We investigated the effect of chloroquine, a known inhibitor of autophagy, on sensitization against radiation-induced apoptosis in a panel of five nasopharyngeal carcinoma cell lines and a SV40-transformed nasoepithelial cell line...
2016: PloS One
https://www.readbyqxmd.com/read/27901642/a-generic-rna-pulsed-dc-based-approach-for-developing-therapeutic-intervention-against-nasopharyngeal-carcinoma
#13
Rajeev K Tyagi, Rajesh Parmar, Naisargee Patel
The recurrent nasopharyngeal carcinoma of head-and-neck cancers pathology showed unique symptoms and clinical characteristics. The complexity of pathology poses challenges for developing therapeutic interventional approaches against nasopharyngeal carcinoma (NPC). The conventional treatment regimens offer limited local control and survival, which, leads to adverse delayed complications. Our study present a generic monocyte derived dendritic cell (MoDC) vaccine strategy for NPC in which RNA is used as a source of tumor-associated antigens (TAAgs)...
November 30, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27900757/unsuspected-axillary-lymph-node-metastasis-of-nasopharyngeal-and-cervical-cancer-on-18fdg-pet-ct-a-case-report
#14
Sungmin Kang
Axillary lymph node metastasis (ALNM) from cancer except breast cancer is rare. Whole body 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) that simultaneously offers anatomic and metabolic information is widely used and has become an effective modality in many clinical fields, especially oncology, and also may detect an unexpected metastasis. We report two cases of ALMN of nasopharyngeal and cervical cancer that was detected on whole body PET/CT.
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27900042/antitumor-activity-of-7rh-a-discoidin-domain-receptor-1-inhibitor-alone-or-in-combination-with-dasatinib-exhibits-antitumor-effects-in-nasopharyngeal-carcinoma-cells
#15
Qiu-Ping Lu, Wen-Dan Chen, Jie-Ren Peng, Yao-Dong Xu, Qian Cai, Gong-Kan Feng, Ke Ding, Xiao-Feng Zhu, Zhong Guan
Dysregulation of the discoidin domain receptors (DDRs) has been implicated in the development of numerous types of tumors, including head and neck cancer, and nasopharyngeal, breast, ovarian and esophageal carcinomas. Furthermore, agents that inhibit DDR1 activity are hypothesized to be useful for the treatment of nasopharyngeal carcinoma (NPC). The aim of the present study was to evaluate the effect of the DDR1 inhibitory (3-(2-(pyrazolo(1,5-a)pyrimidin-6-yl)-ethynyl)benzamide compound, 7RH, in NPC cells both in vitro and in vivo, and its effect when used in combination with dasatinib, a SRC family kinase (SFK) inhibitor...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899161/multiple-molecular-detection-of-respiratory-viruses-and-associated-signs-of-airway-inflammation-in-racehorses
#16
Nadia Doubli-Bounoua, Eric A Richard, Albertine Léon, Pierre-Hugues Pitel, Stéphane Pronost, Guillaume Fortier
BACKGROUND: The potential involvement of viruses in inflammatory airway disease (IAD) was previously investigated through either serology or PCR from nasopharyngeal swabs (NS). The aims of this study were to determine the prevalence and incidence of viral genome detection by qPCR in the equine airways, and their association with respiratory clinical signs. METHODS: Both NS and tracheal washes (TW) were collected monthly on 52 Standardbred racehorses at training, over 27 consecutive months (581 samples)...
November 29, 2016: Virology Journal
https://www.readbyqxmd.com/read/27899105/non-invasive-mechanical-ventilation-after-heart-surgery-in-children
#17
Sarah Fernández Lafever, Blanca Toledo, Miguel Leiva, Maite Padrón, Marina Balseiro, Angel Carrillo, Jesús López-Herce
BACKGROUND: The purpose of the study was to analyze the characteristics and evolution of non-invasive mechanical ventilation (NIV) in the postoperative period of heart surgery in children. METHODS: Retrospective observational study including all children requiring NIV after heart surgery in a single center pediatric intensive care unit (PICU) between 2001 and 2012. Demographic characteristics, ventilation parameters and outcomes were registered, comparing the first 6 years of the study with the last 6 years...
November 29, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27898198/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-nasopharyngeal-cancer-a-review-of-the-national-comprehensive-cancer-network-guidelines
#18
Zhen Gooi, Jeremy Richmon, Nishant Agrawal, Elizabeth Blair, Louis Portugal, Everett Vokes, Tanguy Seiwert, Jonas de Souza, Vassiliki Saloura, Daniel Haraf, David Goldenberg, Jason Chan
This article is a continuation of the "Do You Know Your Guidelines" series, an initiative of the American Head and Neck Society's Education Committee to increase awareness of current best practices pertaining to head and neck cancer. The National Comprehensive Cancer Network guidelines for the management of nasopharyngeal cancer are reviewed here in a systematic fashion. These guidelines outline the workup, treatment and surveillance of patients with nasopharyngeal cancer. © 2016 Wiley Periodicals, Inc. Head Neck, 2016...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27898191/reirradiation-with-intensity-modulated-radiotherapy-for-locally-recurrent-t3-to-t4-nasopharyngeal-carcinoma
#19
Oscar S H Chan, Henry C K Sze, Michael C H Lee, Lucy L K Chan, Amy T Y Chang, Sarah W M Lee, Wai Man Hung, Anne W M Lee, Wai Tong Ng
BACKGROUND: The purpose of this study was to assess the efficacy and toxicities of reirradiation using intensity-modulated radiotherapy (IMRT) in patients with locally advanced recurrent nasopharyngeal carcinoma (NPC). METHODS: Thirty-eight patients with consecutive rT3 to rT4 NPC treated between 2005 and 2013 were retrospectively analyzed. RESULTS: The 3-year overall survival (OS), progression-free survival (PFS), and local control rate were 47...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27895493/ct-diagnosed-severe-skull-base-bone-destruction-predicts-distant-bone-metastasis-in-early-n-stage-nasopharyngeal-carcinoma
#20
Wei Yi, Zhi-Gang Liu, Xian Li, Jiao Tang, Chang-Bin Jiang, Jing-Ye Hu, Zi-Wei Tu, Hui Wang, Dao-Li Niu, Yun-Fei Xia
Bone metastasis is the most frequent type of distant metastasis in nasopharyngeal carcinoma (NPC). In this study, we investigated the correlation between the skull base bone destruction and the distant bone metastasis in patients with NPC. A total of 449 cases with NPC who were diagnosed and had definitive radiotherapy from 2001 to 2006 were enrolled in this study. The skull base bone destruction was diagnosed by computed tomography (CT) in all cases, and 191 patients also underwent magnetic resonance imaging scan...
2016: OncoTargets and Therapy
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