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https://www.readbyqxmd.com/read/29679454/primary-lymphoepthelial-carcinoma-of-the-parotid-gland-pictorial-review-of-a-rare-entity
#1
Arani Halder, Jennifer Sommerville, Mitesh Gandhi
Lymphoepithelial carcinoma (LEC) is a rare malignancy of the salivary gland arising from the parotid in 80% of cases. LEC is indistinguishable histologically from more common non-keratinising undifferentiated nasopharyngeal carcinoma (NPC). Up to 40% of patients with primary LEC present with a cervical metastasis and histological assessment of the primary lesion or nodal metastasis may be reported as NPC. The absence of a nasopharyngeal lesion on imaging and endoscopic assessment together with a parotid mass strengthens the case for a LEC...
April 20, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29678500/a-bench-top-automated-workstation-for-nucleic-acid-isolation-from-clinical-sample-types
#2
Nitu Thakore, Steve Garber, Arial Bueno, Peter Qu, Ryan Norville, Michael Villanueva, Darrell P Chandler, Rebecca Holmberg, Christopher G Cooney
Systems that automate extraction of nucleic acid from cells or viruses in complex clinical matrices have tremendous value even in the absence of an integrated downstream detector. We describe our bench-top automated workstation that integrates our previously-reported extraction method - TruTip - with our newly-developed mechanical lysis method. This is the first report of this method for homogenizing viscous and heterogeneous samples and lysing difficult-to-disrupt cells using "MagVor": a rotating magnet that rotates a miniature stir disk amidst glass beads confined inside of a disposable tube...
April 17, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29677988/gaining-insights-on-nasopharyngeal-carcinoma-treatment-outcome-using-clinical-data-mining-techniques
#3
A Ammar Ghaibeh, Asem Kasem, Xun Jin Ng, Hema Latha Krishna Nair, Jun Hirose, Vinesh Thiruchelvam
The analysis of Electronic Health Records (EHRs) is attracting a lot of research attention in the medical informatics domain. Hospitals and medical institutes started to use data mining techniques to gain new insights from the massive amounts of data that can be made available through EHRs. Researchers in the medical field have often used descriptive statistics and classical statistical methods to prove assumed medical hypotheses. However, discovering new insights from large amounts of data solely based on experts' observations is difficult...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677532/sulforaphane-promotes-apoptosis-and-inhibits-proliferation-and-self-renewal-of-nasopharyngeal-cancer-cells-by-targeting-stat-signal-through-mirna-124-3p
#4
Xiqing Li, Zunlan Zhao, Ming Li, Mingyue Liu, Andres Bahena, Yaping Zhang, Yuwei Zhang, Chetan Nambiar, Guangzhi Liu
Sulforaphane (SF) exhibits an anti-tumor effect in a variety of cancers, but little is known about its function in nasopharyngeal carcinoma. SF could decrease the expression of stem cell markers, β-catenin, Nanog, c-Myc, Oct3/4 and Sox2 in nasopharyngeal cancer cells (HONE1 and SUN1), and inhibit the formation of tumor spheres. Moreover, SF inhibits proliferation and induces apoptosis decreasing the stemness of nasopharyngeal cancer cells through a mechanism related to STAT3 signaling in vitro. We found that SF inhibits total STAT3 expression level and STAT3 phosphorylation (troy 704 and troy 705) by upregulation of miRNA-124-3p...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29676515/characterization-of-a-novel-allelic-variant-in-hla-b-40-lineage-hla-b-40-298-02-by-cloning-and-sequencing
#5
W Tian, F M Zhu, W Y Wang, L X Li, J H Cai
A novel allelic variant in HLA-B*40 lineage, HLA-B*40:298:02, has been identified in an individual of Han ethnicity afflicted with nasopharyngeal carcinoma in Hunan province, southern China. Following polymerase chain reaction-Sanger sequence-based typing (PCR-SBT), this new variant was further confirmed by two distinct strategies of cloning and sequencing. HLA-B*40:298:02 differs from HLA-B*40:298:01 by a single synonymous cytosine substitution at nucleotide position 26 (T→C) in exon 3, which corresponds to codon 99 of the mature HLA-B mRNA molecule...
April 20, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29676365/rapid-detection-of-respiratory-syncytial-virus-in-community-acquired-lower-respiratory-tract-infections-in-children-by-chromatographic-assay
#6
Surinder Kumar, Bhanu Mehra, Gulshan Rai Sethi, Sanjeev R Saigal
Respiratory syncytial virus (RSV) is the single most important viral agent causing pediatric lower respiratory tract infections (LRTIs) worldwide. To evaluate the role of RSV in pediatric LRTIs, we studied 85 children <2 years of age hospitalized for community-acquired LRTIs. Nasopharyngeal aspirates were obtained on admission for the detection of RSV antigen by immunochromatographic assay. Demographic, clinical, and radiological findings for RSV antigen were compared. Data analysis was performed by Chi-square test...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676132/-inhibition-of-yiqi-jiedu-formula-on-proliferation-of-nasopharyngeal-carcinoma-cells-by-mapk-erk-signaling-pathway
#7
Jing Hu, Na Dai, Bing-Yan Xu, Fang-Liang Zhou, Ting Lin, Jing-Jing Luo, Jing-Ying Fan, Ying-Chun He
To study the effect of aqueous extracts of Yiqi Jiedu formula (YQ) on the proliferation of CNE2 cells in human nasopharyngeal carcinoma, and investigate its mechanism to provide a new theoretical basis for the clinical application of YQ. CNE2 cells were treated with different concentrations (0.125, 0.25, 0.5, 0.25 g·L⁻¹) of YQ, positive control medicine (cisplatin 4.0 mg·L⁻¹), inhibitor PD98059 (50 μmol·L⁻¹), activator isoproterenol hydrochloride (20 μmol·L⁻¹), activator isoproterenol hydrochloride (ISO)+YQ 0...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675400/simultaneous-detection-of-key-bacterial-pathogens-related-to-pneumonia-and-meningitis-using-multiplex-pcr-coupled-with-mass-spectrometry
#8
Chi Zhang, Leshan Xiu, Yan Xiao, Zhengde Xie, Lili Ren, Junping Peng
Pneumonia and meningitis continue to present an enormous public health burden and pose a major threat to young children. Among the causative organisms of pneumonia and meningitis, bacteria are the most common causes of serious disease and deaths. It is challenging to accurately and rapidly identify these agents. To solve this problem, we developed and validated a 12-plex PCR coupled with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) method (bacterial pathogen-mass spectrometry, BP-MS) that can be used to simultaneously screen for 11 key bacterial pathogens related to pneumonia and meningitis...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29675112/patterns-of-failure-and-survival-trends-of-720-patients-with-stage-i-nasopharyngeal-carcinoma-diagnosed-from-1990-2012-a-large-scale-retrospective-cohort-study
#9
Lin-Quan Tang, Tong-Yu Lu, Yang Li, Shao-Yan Guo, Qi-Yu Zhong, Meng-Sha Zou, Bo-Lin Chen, Qing-Nan Tang, Wen-Hui Chen, Shan-Shan Guo, Li-Ting Liu, Qiu-Yan Chen, Ling Guo, Hao-Yuan Mo, Rui Sun, Dong-Hua Luo, Chong Zhao, Chao-Nan Qian, Xiang Guo, Mu-Sheng Zeng, Hai-Qiang Mai
Objectives: To evaluate the patterns of failure and survival trends of patients with stage I nasopharyngeal carcinoma (NPC) treated with radiotherapy alone over the last 20 years. Materials and Methods: A retrospective cohort study was conducted on 720 patients with stage I NPC who were treated with curative two-dimensional radiotherapy (2DRT), three-dimensional conformal radiotherapy (3DRT), or intensity-modulated radiotherapy (IMRT) between January 1990 and December 2012. The patients were categorized into four calendar periods (1990-1996, 1997-2002, 2003-2007, and 2008-2012) and four age subgroups (18-39, 40-49, 50-59, and >60)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29673164/perspective-contribution-of-epstein-barr-virus-ebv-reactivation-to-the-carcinogenicity-of-nasopharyngeal-cancer-cells
#10
Chung-Chun Wu, Chih-Yeu Fang, Sheng-Yen Huang, Shih-Hsin Chiu, Chia-Huei Lee, Jen-Yang Chen
Nasopharyngeal carcinoma (NPC) is a squamous cell carcinoma derived from the epithelium of the post-nasal cavity, with a unique geographic and ethnic distribution. Epstein&ndash;Barr virus (EBV) is an etiological agent of NPC, but how it contributes to carcinogenesis is not completely clear. Although it is thought that EBV latency participates in the development of NPC, increasing evidence reveals that the lytic cycle also plays an important role in the carcinogenic process. In this review, we summarize our recent studies on how EBV reactivation causes genomic instability and accelerates tumorigenesis in epithelial cells...
April 17, 2018: Cancers
https://www.readbyqxmd.com/read/29672367/characterization-of-pd-l1-and-pd-1-expression-and-cd8-tumor-infiltrating-lymphocyte-in-epstein-barr-virus-associated-nasopharyngeal-carcinoma
#11
Noppadol Larbcharoensub, Komkrit Mahaprom, Chuleeporn Jiarpinitnun, Narumol Trachu, Nattha Tubthong, Poompis Pattaranutaporn, Ekaphop Sirachainan, Nuttapong Ngamphaiboon
OBJECTIVES: Immunotherapies that target the programmed death-1/ programmed death-1 ligand (PD-1/PD-L1) immune checkpoint pathway have shown promise in nasopharyngeal carcinoma (NPC) in early phases clinical studies. Here, we evaluated PD-1 and PD-L1 expression and CD8+ tumor-infiltrating lymphocytes (TILs) in NPC patients. MATERIALS AND METHODS: Newly diagnosed NPC patients were identified through the institutional database between January 2007 and December 2012...
April 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29671041/oropharyngeal-and-nasopharyngeal-decontamination-with-chlorhexidine-gluconate-in-lung-cancer-surgery-a-randomized-clinical-trial
#12
Xavier Benoit D'Journo, Pierre-Emmanuel Falcoz, Marco Alifano, Jean-Philippe Le Rochais, Thomas D'Annoville, Gilbert Massard, Jean Francois Regnard, Philippe Icard, Charles Marty-Ane, Delphine Trousse, Christophe Doddoli, Bastien Orsini, Sophie Edouard, Matthieu Million, Nathalie Lesavre, Anderson Loundou, Karine Baumstarck, Florence Peyron, Stephane Honoré, Stéphanie Dizier, Aude Charvet, Marc Leone, Didier Raoult, Laurent Papazian, Pascal Alexandre Thomas
PURPOSE: Respiratory complications are the leading causes of morbidity and mortality after lung cancer surgery. We hypothesized that oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate (CHG) would be an effective method to reduce these complications as reported in cardiac surgery. METHODS: In this multicenter parallel-group randomized double-blind placebo-controlled trial, we enrolled consecutive adults scheduled for anatomical pulmonary resection for lung cancer...
April 18, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29670379/assessment-of-an-accessorized-pre-filled-syringe-for-home-administered-benralizumab-in-severe-asthma
#13
Gary T Ferguson, Adel H Mansur, Joshua S Jacobs, Jacques Hebert, Corbin Clawson, Wenli Tao, Yanping Wu, Mitchell Goldman
Background: Patients prefer at-home subcutaneous administration of biologics across different diseases, yet no biologic is approved for at-home use for severe, uncontrolled asthma. Objective: We assessed at-home functionality, reliability, and performance of an accessorized pre-filled syringe (APFS) for subcutaneous benralizumab administration, an anti-eosinophil monoclonal antibody indicated for add-on maintenance treatment of patients with severe eosinophilic asthma...
2018: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/29669359/low-ct-attenuation-values-of-sinonasal-benign-tumours-relative-to-the-brainstem-identify-schwannomas
#14
Tomoaki Nakada, Shu Kikuta, Harushi Mori, Yuya Shimizu, Hironobu Nishijima, Kenji Kondo, Tatsuya Yamasoba
OBJECTIVES: On computed tomography (CT), sinonasal schwannoma displays as a soft-tissue mass without any distinctive features. Our aim was to define the radiological criteria for distinguishing schwannoma from other sinonasal benign tumours. METHODS: We retrospectively identified consecutive patients who were pathologically diagnosed with benign sinonasal tumours between 2007 and 2016. CT attenuation values were compared between benign tumours and the brainstem...
April 17, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29668861/continuous-invasion-by-respiratory-viruses-observed-in-rural-households-during-a-respiratory-syncytial-virus-seasonal-outbreak-in-coastal-kenya
#15
Patrick K Munywoki, Dorothy C Koech, Charles N Agoti, Patricia A Cane, Graham F Medley, D James Nokes
Background: Households are high intensity close-contact environments favorable for transmission of respiratory viruses, yet little is known for low-income settings. Methods: Active surveillance was completed on 47 households in rural coastal Kenya over six months during a respiratory syncytial virus(RSV) season. Nasopharyngeal swabs(NPS) were taken from 483 household members twice-weekly irrespective of symptoms. NPS from 6 households were screened for 15 respiratory viruses by molecular diagnostics and the remainder only for the most frequent viruses observed: rhinovirus (RV), human coronaviruses(hCoV; comprising 229E, OC43 and NL63), adenovirus(AdV) and RSV(A and B)...
April 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29668598/brain-abscess-caused-by-chronic-invasive-actinomycosis-in-the-nasopharynx-a-case-report-and-literature-review
#16
Chi Sang Hwang, Haneul Lee, Min Pyo Hong, Ji Hyung Kim, Kyung-Su Kim
RATIONALE: Actinomycosis is a rare anaerobic, gram-positive bacterial infection caused by Actinomyces, which is part of the normal flora in the oral cavity and respiratory and female genitourinary tracts. The cervicofacial area is the most common site of involvement, and involvement of the central nervous system is rare. PATIENT CONCERNS: We report a case involving a 51-year-old woman who developed an actinomycotic brain abscess 15 months after the treatment of noninvasive nasopharyngeal actinomycosis, which recurred as an invasive form...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668108/sonographic-assessment-of-swallowing-in-irradiated-nasopharyngeal-carcinoma-patients
#17
Dennis T H Cheng, Kathy Y S Lee, Anil T Ahuja, Michael C F Tong
OBJECTIVES/HYPOTHESIS: Ultrasonography is an emerging clinical tool to study the dysfunction of swallowing muscles. This was the first sonographic study to assess the relationship between suprahyoid muscle contraction, hyoid bone displacement, and penetration-aspiration status (PAS) during swallowing in nasopharyngeal carcinoma (NPC) patients treated with radiotherapy (RT). The study also aimed to establish reliability data for the sonographic technique described. STUDY DESIGN: Cross-sectional study...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29667896/a-phase-1-study-to-assess-the-pharmacokinetics-safety-and-tolerability-of-fremanezumab-doses-225-mg-675-mg-and-900-mg-in-japanese-and-caucasian-healthy-subjects
#18
Orit Cohen-Barak, Sivan Weiss, Michele Rasamoelisolo, Nicola Faulhaber, Paul P Yeung, Pippa S Loupe, Esther Yoon, Mohit D Gandhi, Ofer Spiegelstein, Ernesto Aycardi
Objectives The primary and secondary objectives of this phase 1 study were to evaluate the pharmacokinetic profile, safety, and immunogenicity of fremanezumab subcutaneous (sc) doses tested in phase 2 and 3 trials (225 mg, 675 mg and 900 mg) following single administration in Japanese (n = 32) and Caucasian (n = 32) healthy subjects. Methods Japanese and matched Caucasian healthy subjects were enrolled into one of four cohorts and were randomly assigned to one of four treatments: 225, 675, or 900 mg fremanezumab, or placebo...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29667812/turning-on-off-the-anti-tumor-effect-of-au-cluster-via-atomically-controlling-its-molecular-size
#19
Jiao Zhai, Yanwei Jia, Lina Zhao, Qing Yuan, Fuping Gao, Xiangchun Zhang, Pengju Cai, Liang Gao, Juanjuan Guo, Shuhong Yi, Zhifang Chai, Yuliang Zhao, Xueyun Gao
We reported two Au clusters with precisely controlled molecular size (Au5Peptide3 and Au22Peptide10) showing different anti-tumor effects. In vitro, both Au5Peptide3 and Au22Peptide10 were well taken up by human nasopharyngeal cancer cells (CNE1 cells). However, only Au5Peptide3 significantly induced CNE1 cell apoptosis. Further studies showed that CNE1 cells took up Au5Peptide3 (1.98*10-15 mol/cell) and 9% of them entered mitochondria (0.186*10-15 mol/cell). As a comparison, the uptake of Au22Peptide10 was only half the amount of Au5Peptide3 (1...
April 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29667096/evaluation-of-the-novel-non-invasive-zero-heat-flux-tcore%C3%A2-thermometer-in-cardiac-surgical-patients
#20
José A Sastre, María J Pascual, Teresa López
Tcore™ Sensor is a novel zero-heat-flux thermometer that estimates core temperature from skin over forehead. We tested the hypothesis that this system estimates core temperature to an accuracy within 0.5 °C. 40 cardiac surgical patients were enrolled (960 measurements). Reference core temperatures were measured in nasopharynx, pulmonary artery and the arterial branch of the oxygenator of the cardiopulmonary bypass (CPB) circuit. 95% Bland-Altman limits of agreement for repeated measurement data was used to study the agreement between Tcore™ thermometer and the reference methods...
April 17, 2018: Journal of Clinical Monitoring and Computing
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