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Katherine A Dudley, Jia Weng, Daniela Sotres-Alvarez, Guido Simonelli, Elizabeth Cespedes, Maricelle Ramirez, Alberto R Ramos, Jose S Loredo, Kathryn J Reid, Yasmin Mossavar-Rahmani, Phyllis C Zee, Diana A Chirinos, Linda C Gallo, Rui Wang, Sanjay R Patel
STUDY OBJECTIVE: To assess the extent to which objective sleep patterns vary among U.S. Hispanics/Latinos. METHODS: We assessed objective sleep patterns in 2,087 participants of the Hispanic Community Health Study/Study of Latinos from six Hispanic/Latino subgroups aged 18-64 years who underwent 7 days of wrist actigraphy. RESULTS: The age- and sex-standardized mean (SE) sleep duration was 6.82 (0.05), 6.72 (0.07), 6.61 (0.07), 6.59 (0.06), 6...
October 28, 2016: Sleep
Bharat Thyagarajan, Annie Green Howard, Ramon Durazo-Arvizu, John H Eckfeldt, Marc D Gellman, Ryung S Kim, Kiang Liu, Armando J Mendez, Frank J Penedo, Gregory A Talavera, Marston E Youngblood, Lihui Zhao, Daniela Sotres-Alvarez
BACKGROUND: Biomarker variability, which includes within-individual variability (CVI), between-individual variability (CVG) and methodological variability (CVP+A) is an important determinant of our ability to detect biomarker-disease associations. Estimates of CVI and CVG may be population specific and little data exists on biomarker variability in diverse Hispanic populations. Hence, we evaluated all 3 components of biomarker variability in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) using repeat blood collections (n=58) and duplicate blood measurements (n=761-929 depending on the biomarker)...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
Cigdem Yucel Falco, Javier Sotres, Ana Rascón, Jens Risbo, Marité Cárdenas
HYPOTHESIS: Chitosan and sulfated oat β-glucan are materials suitable to create a prebiotic coating for targeted delivery to gastrointestinal system, using the layer by layer technology. EXPERIMENT: Quartz crystal microbalance with dissipation (QCM-D), spectroscopic ellipsometry (SE) and atomic force microscopy (AFM) were used to assess the multilayer formation capacity and characterize the resulting coatings in terms of morphology and material properties such as structure and rigidity...
October 12, 2016: Journal of Colloid and Interface Science
Leticia Ramírez-Lugo, Ana Peñas-Rincón, Sandybel Ángeles-Durán, Francisco Sotres-Bayon
: The ability to select an appropriate behavioral response guided by previous emotional experiences is critical for survival. Although much is known about brain mechanisms underlying emotional associations, little is known about how these associations guide behavior when several choices are available. To address this, we performed local pharmacological inactivations of several cortical regions before retrieval of an aversive memory in choice-based versus no-choice-based conditioned taste aversion (CTA) tasks in rats...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Elisa Gabanti, Francesca Bruno, Lucia Scaramuzzi, Filippo Mangione, Paola Zelini, Giuseppe Gerna, Daniele Lilleri
Human cytomegalovirus (HCMV) is still the most common viral infection in solid-organ transplant recipients (SOTR). Our study aimed to identify the predictive values of the T-cell response able to protect from HCMV disease, according to different assays. Viral DNA was determined by real-time PCR. The T-cell immune response to HCMV infection was investigated in SOTR according to the following assays and stimuli: cytokine flow cytometry (CFC) after peripheral blood mononuclear cell (PBMC) stimulation with autologous HCMV-infected dendritic cells (iDC) vs three ELISPOT assays using PBMCs stimulated with: i) HCMV-infected cell lysate (iCL); ii) a pool of 34 epitopic peptides (PP) from different HCMV proteins; iii) a commercial pp65 peptide pool (CPM)...
September 13, 2016: New Microbiologica
Shahid Husain, Fernanda P Silveira, Nkechi Azie, Billy Franks, David Horn
Epidemiological characteristics of 333 proven and probable invasive mould infections (IMIs) among solid organ transplant recipients (SOTRs) identified between 2004 and 2008 from the Prospective Antifungal Therapy Alliance (PATH) registry are presented. Liver transplant recipients (LTRs) had the lowest median time to IMIs (109 days; interquartile range [IQR] 24-611 days), the highest rate of disseminated disease (n/N = 18/33; 55%), and highest mortality (n/N = 21/33; 64%). Lung transplant recipients had highest median time to IMIs (486 days; IQR 117-1358 days) and lowest mortality (n/N = 31/184; 17%)...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Guido Simonelli, Katherine A Dudley, Jia Weng, Linda C Gallo, Krista Perreira, Neomi A Shah, Carmela Alcantara, Phyllis C Zee, Alberto R Ramos, Maria M Llabre, Daniela Sotres-Alvarez, Rui Wang, Sanjay R Patel
STUDY OBJECTIVES: To evaluate whether an adverse neighborhood environment has higher prevalence of poor sleep in a US Hispanic/Latino population. METHODS: A cross-sectional analysis was performed in 2156 US Hispanic/Latino participants aged 18-64 years from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Participants completed surveys of neighborhood environment including perceived safety, violence and noise, the Insomnia Severity Index (ISI), and 7 days of wrist actigraphy...
September 26, 2016: Sleep
José Carlos Páez-Franco, Ignacio González-Sánchez, Nora A Gutiérrez-Nájera, Lilián G Valencia-Turcotte, Alfonso Lira-Rocha, Marco A Cerbón, Rogelio Rodríguez-Sotres
9-[(3-chloro)phenylamine]-2-[3-(diethylamine)propylamine]thiazolo[5,4-b]quinolone (D3ClP) is a bioisostere of N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide (m-AMSA) a DNA topoisomerase II inhibitor with proven cytotoxic activity and known to induce DNA damage and apoptotic cell death in K562 cells. However, recent evidence is not consistent with DNA topoisomerase II (DNA TOP2) as the primary target of D3ClP, in contrast to m-AMSA. We provide evidence of histone γH2AX phosphorylation at Ser135 in HeLa cells treated with D3ClP, a marker of DNA double strand repair through Mre11-Rad50-Nbs1 (MRN) pathway...
September 29, 2016: Journal of Cellular Biochemistry
Chantel L Martin, Anna Maria Siega-Riz, Daniela Sotres-Alvarez, Whitney R Robinson, Julie L Daniels, Eliana M Perrin, Alison M Stuebe
BACKGROUND: Child obesity is a major problem in the United States. Identifying early-life risk factors is necessary for prevention. Maternal diet during pregnancy is a primary source of fetal energy and might influence risk of child obesity. OBJECTIVE: We prospectively investigated the influence of maternal dietary patterns during pregnancy on child growth in the first 3 y of life in 389 mother-child pairs from the Pregnancy, Infection, and Nutrition study. METHODS: Dietary patterns were derived with the use of latent class analysis (LCA) based on maternal diet, collected with the use of a food-frequency questionnaire at 26-29 wk gestation...
November 2016: Journal of Nutrition
Josiemer Mattei, Daniela Sotres-Alvarez, Martha L Daviglus, Linda C Gallo, Marc Gellman, Frank B Hu, Katherine L Tucker, Walter C Willett, Anna Maria Siega-Riz, Linda Van Horn, Robert C Kaplan
BACKGROUND: Healthful diet quality has been associated with a lower risk of metabolic syndrome (MetS) in several populations, but reports on Hispanic and Latino cohorts, grouped or by ethnic background, have been limited and inconsistent. OBJECTIVE: We aimed to examine diet quality by using the 2010 Alternate Healthy Eating Index [(AHEI) range: 0-110, lowest to highest quality] and its cross-sectional association with MetS and its cardiometabolic components across 6 Hispanic and Latino backgrounds...
October 2016: Journal of Nutrition
Jan Busk Madsen, Javier Sotres, Kirsi I Pakkanen, Petr Efler, Birte Svensson, Maher Abou Hachem, Thomas Arnebrant, Seunghwan Lee
The structural and mechanical properties of thin films generated from two types of mucins, namely, bovine submaxillary mucin (BSM) and porcine gastric mucin (PGM) in aqueous environment were investigated with several bulk and surface analytical techniques. Both mucins generated hydrated films on hydrophobic polydimethylsiloxane (PDMS) surfaces from spontaneous adsorption arising from their amphiphilic characteristic. However, BSM formed more elastic films than PGM at neutral pH condition. This structural difference was manifested from the initial film formation processes to the responses to shear stresses applied to the films...
September 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
C D Blosser
No abstract text is available yet for this article.
September 2, 2016: American Journal of Transplantation
Melecia Wright, Michelle Ann Mendez, Daniela Sotres-Alvarez, Linda Adair
BACKGROUND: Protein intake (PI) may alter adiposity but few studies have explored the age-specific associations of PI with body mass index (BMI). OBJECTIVE: We analyzed how PI and breastfeeding relate to BMI in the CLHNS (Cebu Longitudinal Health and Nutrition Survey), an observational Filipino birth cohort (1983-2005). METHODS: Random-effects longitudinal regression models estimated the association of daily breastfeeding frequency and energy-adjusted PI residuals with concurrent BMI z scores (zBMI) measured bimonthly from 2 to 24 mo (n = 2899), and the association of breastfeeding history and PI residuals with concurrent BMI using 5 surveys from 2 to 22 y (n = 2435)...
October 2016: Journal of Nutrition
S A Acuna, J W Huang, A L Scott, S Micic, C Daly, C Brezden-Masley, S Joseph Kim, N N Baxter
Solid organ transplant recipients (SOTRs) are at increased risk of developing and dying from cancer. However, controversies exist around cancer screening in this population owing to reduced life expectancy and competing causes of death. This systematic review assesses the availability, quality and consistency of cancer screening recommendations in clinical practice guidelines (CPGs). We systematically searched bibliographic databases and gray literature to identify CPGs and assessed their quality using AGREE II...
August 30, 2016: American Journal of Transplantation
Jill Neale, Alice C Smith, Nicolette C Bishop
Solid organ transplantation is the criterion standard treatment for many with end-organ failure and can offer a new independence from the burden of disease. However solid organ transplant recipients (SOTRs) remain at high risk of cardiovascular (CV) disease, and poor quality of life and physical functioning. Increasing physical activity and exercise can improve the health of the general population; however, the effects on those with a transplant remain unclear. Intensive exercise and sporting activity has the potential to be beneficial, although there remain concerns particularly around the effects on immune function and the CV system...
August 22, 2016: American Journal of Physical Medicine & Rehabilitation
Alberto R Ramos, Wassim Tarraf, Martha Daviglus, Sonia Davis, Linda C Gallo, Yasmin Mossavar-Rahmani, Frank J Penedo, Susan Redline, Tatjana Rundek, Ralph L Sacco, Daniela Sotres-Alvarez, Clinton B Wright, Phyllis C Zee, Hector M González
STUDY OBJECTIVES: To evaluate the association between sleep duration and neurocognitive function in a representative sample of middle-aged to older Hispanic/Latino adults in the US. We tested the hypothesis that sleep duration has a nonlinear, inverted U-shaped association with neurocognitive function. METHODS: We performed a cross-sectional analysis from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants ages 45-74 years (n = 8,676). HCHS/SOL is a community-based cohort from four US urban areas sampled using a probability design from 2008-2011...
October 1, 2016: Sleep
Avelina Sotres-Vega, Jaime Villalba-Caloca, Shely Azrad-Daniel, Jazmín A García-Montes, J Luis Torre-Jaime, Isabel Guadarrama-Sánchez, Diana Pérez-Covarrubias, J Alfredo Santibañez-Salgado
The objective of this study is to present a high-fidelity bench model of cryopreserved stomachs that can be used while learning surgical skills. Thirty stomachs were harvested from Wistar rats at the end of non-abdominal research studies. The stomachs were washed with cold saline solution and filled with hyaluronic acid solution. The organs were then placed into cryovials and cryopreserved at -30 °C for 60 days. The stomachs were thawed to room temperature on the day of the surgical skills practice and two full-thickness incisions were made...
2016: Journal of Veterinary Medical Education
Jennifer J Harrison, Souzi Badr, Bassem Hamandi, Sang Joseph Kim
BACKGROUND: De novo solid organ transplant recipients (SOTR) have a steep learning curve to acquire medication knowledge. Without adequate knowledge, SOTR are at risk of nonadherence and poor transplant outcomes. METHODS: In this nonblinded, randomized controlled trial, de novo SOTR received standard teaching with or without postdischarge computer-based education (CBE) at home. Primary outcomes were change in knowledge (quiz and recall) and satisfaction, assessed by questionnaires at baseline and 3 months...
June 30, 2016: Transplantation
J M Beasley, M Jung, N Tasevska, W W Wong, A M Siega-Riz, D Sotres-Alvarez, M D Gellman, J R Kizer, P A Shaw, J Stamler, M Stoutenberg, L Van Horn, A A Franke, J Wylie-Rosett, Y Mossavar-Rahmani
OBJECTIVE: Measurement error in self-reported total sugars intake may obscure associations between sugars consumption and health outcomes, and the sum of 24 h urinary sucrose and fructose may serve as a predictive biomarker of total sugars intake. DESIGN: The Study of Latinos: Nutrition & Physical Activity Assessment Study (SOLNAS) was an ancillary study to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) cohort. Doubly labelled water and 24 h urinary sucrose and fructose were used as biomarkers of energy and sugars intake, respectively...
June 24, 2016: Public Health Nutrition
Jiali Zhou, Yani Liu, Xiaomei Luo, Rufei Shen, Chunxiao Yang, Tingyu Yang, Shaojun Shi
The activation of Ras-related C3 botulinum toxin substrate 1 (Rac1) is critical in the renal, hepatic and cardiac diseases that lead to the requirement for transplantation, however, no investigations have been performed in Chinese populations to determine the association between RAC1 genotypes and the activation of Rac1. In the present study, 304 solid organ transplant recipients (SOTRs), consisting of 164 renal transplantations, 85 hepatic transplantations and 55 cardiac transplantations, and 332 Chinese healthy control subjects were recruited to investigate whether differences existed in the mRNA and protein expression levels of Rac1 in the different groups...
August 2016: Molecular Medicine Reports
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