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https://www.readbyqxmd.com/read/28093535/hepatitis-e-in-singapore-a-case-series-and-viral-phylodynamics-study
#1
Esmeralda Chi-Yuan Teo, Boon-Huan Tan, Michael A Purdy, Pui-San Wong, Pei-Jun Ting, Pik-Eu Jason Chang, Lynette Lin-Ean Oon, Amanda Sue, Chong-Gee Teo, Chee-Kiat Tan
The incidence of hepatitis E in Singapore appears to be increasing. A retrospective case-series study of patients diagnosed with hepatitis E in a tertiary hospital from 2009 to 2013 was conducted. Of 16 cases, eight (50%) were solid-organ transplant recipients (SOTRs), and 14 (88%) were found infected by genotype 3 hepatitis E virus (HEV-3). Bayesian inferences based on HEV subgenomic sequences from seven cases suggest that HEV-3 strains were introduced to Singapore as two principal lineages. Within limitations of the study, it can be inferred that one lineage, in the 3efg clade, emerged about 83 years ago, probably originating from Japan, whereas the other, in the 3abchij clade, emerged about 40 years ago, from the United States...
January 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28024863/targeting-physical-activity-interventions-for-adults-when-should-intervention-occur
#2
Katelyn M Holliday, Dan Yu Lin, Sujatro Chakladar, Sheila F Castañeda, Martha L Daviglus, Kelly R Evenson, David X Marquez, Qibin Qi, Christina M Shay, Daniela Sotres-Alvarez, Denise C Vidot, Donglin Zeng, Christy L Avery
Understanding demographic differences in transitions across physical activity (PA) levels is important for informing PA-promoting interventions, yet few studies have examined these transitions in contemporary multi-ethnic adult populations. We estimated age-, race/ethnicity-, and sex-specific 1-year net transition probabilities (NTPs) for National Health and Nutrition Examination Survey (2007-2012, n=11,556) and Hispanic Community Health Study/Study of Latinos (2008-2011, n=15,585) adult participants using novel Markov-type state transition models developed for cross-sectional data...
December 23, 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27968992/evidence-for-a-non-overlapping-subcellular-localization-of-the-family-i-isoforms-of-soluble-inorganic-pyrophosphatase-in-arabidopsis-thaliana
#3
Francisca Morayna Gutiérrez-Luna, Ernesto Navarro de la Sancha, Lilián Gabriela Valencia-Turcotte, Sonia Vázquez-Santana, Rogelio Rodríguez-Sotres
Pyrophosphate is a byproduct of macromolecular biosynthesis and its degradation gives a thermodynamic impulse to cell growth. Soluble inorganic pyrophosphatases (PPa) are present in all living cells, but in plants and other Eukaryotes membrane-bound H+-pumping pyrophosphatases may compete with these soluble counterparts for the substrate. In Arabidopsis thaliana there are six genes encoding for classic family I PPa isoforms, five cytoplasmic, and one considered to be organellar. Here, six transgenic stable A...
December 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27935792/youth-and-caregiver-physical-activity-and-sedentary-time-hchs-sol-youth
#4
Linda C Gallo, Scott P Roesch, Jessica L McCurley, Carmen R Isasi, Daniela Sotres-Alvarez, Alan M Delamater, Linda Van Horn, Elva M Arredondo, Krista M Perreira, Christina Buelna, Qibin Qi, Denise C Vidot, Mercedes R Carnethon
OBJECTIVES: We examined associations between youth and caregiver moderate/ vigorous physical activity (MVPA) and sedentary (SED) time, using accelerometery, in the Hispanic Community Health Study/Study of Latino Youth (HCHS/ SOL) Youth. METHODS: Participants were 623 caregivers and 877 youth 8-16 years old, enrolled in 2012-2014. Associations of youth and caregiver MVPA time, SED time, and meeting MVPA recommendations ( 150 min/week, adults; 420 min/week, youth) were examined in regression models that controlled for sample weights, design effects, and demographic and health covariates...
January 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/27925576/comparison-of-oxygen-transfer-parameters-and-oxygen-demands-in-bioreactors-operated-at-low-and-high-dissolved-oxygen-levels
#5
Richard O Mines, Matthew C Callier, Benjamin J Drabek, André J Butler
The proper design of aeration systems for bioreactors is critical since it can represent up to 50% of the operational and capital cost at water reclamation facilities. Transferring the actual amount of oxygen needed to meet the oxygen demand of the wastewater requires α- and β-factors, which are used for calculating the actual oxygen transfer rate (AOTR) under process conditions based on the standard oxygen transfer rate (SOTR). The SOTR is measured in tap water at 20°C, 1 atmospheric pressure, and 0 mg L(-1) of dissolved oxygen (DO)...
December 7, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27855733/actigraphic-sleep-patterns-of-u-s-hispanics-the-hispanic-community-health-study-study-of-latinos
#6
Katherine A Dudley, Jia Weng, Daniela Sotres-Alvarez, Guido Simonelli, Elizabeth Cespedes, Maricelle Ramirez, Alberto R Ramos, Jose S Loredo, Kathryn J Reid, Yasmin Mossavar-Rahmani, Phyllis C Zee, Diana A Chirinos, Linda C Gallo, Rui Wang, Sanjay R Patel
STUDY OBJECTIVE: To assess the extent to which objective sleep patterns vary among U.S. Hispanics/Latinos. METHODS: We assessed objective sleep patterns in 2,087 participants of the Hispanic Community Health Study/Study of Latinos from six Hispanic/Latino subgroups aged 18-64 years who underwent 7 days of wrist actigraphy. RESULTS: The age- and sex-standardized mean (SE) sleep duration was 6.82 (0.05), 6.72 (0.07), 6.61 (0.07), 6.59 (0.06), 6...
October 28, 2016: Sleep
https://www.readbyqxmd.com/read/27756543/analytical-and-biological-variability-in-biomarker-measurement-in-the-hispanic-community-health-study-study-of-latinos
#7
Bharat Thyagarajan, Annie Green Howard, Ramon Durazo-Arvizu, John H Eckfeldt, Marc D Gellman, Ryung S Kim, Kiang Liu, Armando J Mendez, Frank J Penedo, Gregory A Talavera, Marston E Youngblood, Lihui Zhao, Daniela Sotres-Alvarez
BACKGROUND: Biomarker variability, which includes within-individual variability (CVI), between-individual variability (CVG) and methodological variability (CVP+A) is an important determinant of our ability to detect biomarker-disease associations. Estimates of CVI and CVG may be population specific and little data exists on biomarker variability in diverse Hispanic populations. Hence, we evaluated all 3 components of biomarker variability in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) using repeat blood collections (n=58) and duplicate blood measurements (n=761-929 depending on the biomarker)...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27756004/design-of-a-potentially-prebiotic-and-responsive-encapsulation-material-for-probiotic-bacteria-based-on-chitosan-and-sulfated-%C3%AE-glucan
#8
Cigdem Yucel Falco, Javier Sotres, Ana Rascón, Jens Risbo, Marité Cárdenas
HYPOTHESIS: Chitosan and sulfated oat β-glucan are materials suitable to create a prebiotic coating for targeted delivery to gastrointestinal system, using the layer by layer technology. EXPERIMENT: Quartz crystal microbalance with dissipation (QCM-D), spectroscopic ellipsometry (SE) and atomic force microscopy (AFM) were used to assess the multilayer formation capacity and characterize the resulting coatings in terms of morphology and material properties such as structure and rigidity...
February 1, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27733609/choice-behavior-guided-by-learned-but-not-innate-taste-aversion-recruits-the-orbitofrontal-cortex
#9
Leticia Ramírez-Lugo, Ana Peñas-Rincón, Sandybel Ángeles-Durán, Francisco Sotres-Bayon
: The ability to select an appropriate behavioral response guided by previous emotional experiences is critical for survival. Although much is known about brain mechanisms underlying emotional associations, little is known about how these associations guide behavior when several choices are available. To address this, we performed local pharmacological inactivations of several cortical regions before retrieval of an aversive memory in choice-based versus no-choice-based conditioned taste aversion (CTA) tasks in rats...
October 12, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27727404/predictive-value-of-human-cytomegalovirus-hcmv-t-cell-response-in-the-control-of-hcmv-infection-by-seropositive-solid-organ-transplant-recipients-according-to-different-assays-and-stimuli
#10
Elisa Gabanti, Francesca Bruno, Lucia Scaramuzzi, Filippo Mangione, Paola Zelini, Giuseppe Gerna, Daniele Lilleri
Human cytomegalovirus (HCMV) is still the most common viral infection in solid-organ transplant recipients (SOTR). Our study aimed to identify the predictive values of the T-cell response able to protect from HCMV disease, according to different assays. Viral DNA was determined by real-time PCR. The T-cell immune response to HCMV infection was investigated in SOTR according to the following assays and stimuli: cytokine flow cytometry (CFC) after peripheral blood mononuclear cell (PBMC) stimulation with autologous HCMV-infected dendritic cells (iDC) vs three ELISPOT assays using PBMCs stimulated with: 1...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27703022/epidemiological-features-of-invasive-mold-infections-among-solid-organ-transplant-recipients-path-alliance%C3%A2-registry-analysis
#11
Shahid Husain, Fernanda P Silveira, Nkechi Azie, Billy Franks, David Horn
Epidemiological characteristics of 333 proven and probable invasive mould infections (IMIs) among solid organ transplant recipients (SOTRs) identified between 2004 and 2008 from the Prospective Antifungal Therapy Alliance (PATH) registry are presented. Liver transplant recipients (LTRs) had the lowest median time to IMIs (109 days; interquartile range [IQR] 24-611 days), the highest rate of disseminated disease (n/N = 18/33; 55%), and highest mortality (n/N = 21/33; 64%). Lung transplant recipients had highest median time to IMIs (486 days; IQR 117-1358 days) and lowest mortality (n/N = 31/184; 17%)...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27692058/neighborhood-factors-as-predictors-of-poor-sleep-in-the-sue%C3%A3-o-ancillary-study-of-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#12
Guido Simonelli, Katherine A Dudley, Jia Weng, Linda C Gallo, Krista Perreira, Neomi A Shah, Carmela Alcantara, Phyllis C Zee, Alberto R Ramos, Maria M Llabre, Daniela Sotres-Alvarez, Rui Wang, Sanjay R Patel
STUDY OBJECTIVES: To evaluate whether an adverse neighborhood environment has higher prevalence of poor sleep in a US Hispanic/Latino population. METHODS: A cross-sectional analysis was performed in 2156 US Hispanic/Latino participants aged 18-64 years from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Participants completed surveys of neighborhood environment including perceived safety, violence and noise, the Insomnia Severity Index (ISI), and 7 days of wrist actigraphy...
September 26, 2016: Sleep
https://www.readbyqxmd.com/read/27684057/proteomic-profiling-reveals-the-induction-of-upr-in-addition-to-dna-damage-response-in-hela-cells-treated-with-the-thiazolo-5-4-b-quinoline-derivative-d3clp
#13
José Carlos Páez-Franco, Ignacio González-Sánchez, Nora A Gutiérrez-Nájera, Lilián G Valencia-Turcotte, Alfonso Lira-Rocha, Marco A Cerbón, Rogelio Rodríguez-Sotres
9-[(3-chloro)phenylamine]-2-[3-(diethylamine)propylamine]thiazolo[5,4-b]quinolone (D3ClP) is a bioisostere of N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide (m-AMSA) a DNA topoisomerase II inhibitor with proven cytotoxic activity and known to induce DNA damage and apoptotic cell death in K562 cells. However, recent evidence is not consistent with DNA topoisomerase II (DNA TOP2) as the primary target of D3ClP, in contrast to m-AMSA. We provide evidence of histone γH2AX phosphorylation at Ser135 in HeLa cells treated with D3ClP, a marker of DNA double strand repair through Mre11-Rad50-Nbs1 (MRN) pathway...
September 29, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27683873/maternal-dietary-patterns-during-pregnancy-are-associated-with-child-growth-in-the-first-3-years-of-life
#14
Chantel L Martin, Anna Maria Siega-Riz, Daniela Sotres-Alvarez, Whitney R Robinson, Julie L Daniels, Eliana M Perrin, Alison M Stuebe
BACKGROUND: Child obesity is a major problem in the United States. Identifying early-life risk factors is necessary for prevention. Maternal diet during pregnancy is a primary source of fetal energy and might influence risk of child obesity. OBJECTIVE: We prospectively investigated the influence of maternal dietary patterns during pregnancy on child growth in the first 3 y of life in 389 mother-child pairs from the Pregnancy, Infection, and Nutrition study. METHODS: Dietary patterns were derived with the use of latent class analysis (LCA) based on maternal diet, collected with the use of a food-frequency questionnaire at 26-29 wk gestation...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27605403/diet-quality-and-its-association-with-cardiometabolic-risk-factors-vary-by-hispanic-and-latino-ethnic-background-in-the-hispanic-community-health-study-study-of-latinos
#15
Josiemer Mattei, Daniela Sotres-Alvarez, Martha L Daviglus, Linda C Gallo, Marc Gellman, Frank B Hu, Katherine L Tucker, Walter C Willett, Anna Maria Siega-Riz, Linda Van Horn, Robert C Kaplan
BACKGROUND: Healthful diet quality has been associated with a lower risk of metabolic syndrome (MetS) in several populations, but reports on Hispanic and Latino cohorts, grouped or by ethnic background, have been limited and inconsistent. OBJECTIVE: We aimed to examine diet quality by using the 2010 Alternate Healthy Eating Index [(AHEI) range: 0-110, lowest to highest quality] and its cross-sectional association with MetS and its cardiometabolic components across 6 Hispanic and Latino backgrounds...
October 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27597630/structural-and-mechanical-properties-of-thin-films-of-bovine-submaxillary-mucin-versus-porcine-gastric-mucin-on-a-hydrophobic-surface-in-aqueous-solutions
#16
Jan Busk Madsen, Javier Sotres, Kirsi I Pakkanen, Petr Efler, Birte Svensson, Maher Abou Hachem, Thomas Arnebrant, Seunghwan Lee
The structural and mechanical properties of thin films generated from two types of mucins, namely, bovine submaxillary mucin (BSM) and porcine gastric mucin (PGM) in aqueous environment were investigated with several bulk and surface analytical techniques. Both mucins generated hydrated films on hydrophobic polydimethylsiloxane (PDMS) surfaces from spontaneous adsorption arising from their amphiphilic characteristic. However, BSM formed more elastic films than PGM at neutral pH condition. This structural difference was manifested from the initial film formation processes to the responses to shear stresses applied to the films...
September 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27589841/a-call-to-action-the-need-for-improved-transplant-cancer-screening-guidelines
#17
EDITORIAL
C D Blosser
No abstract text is available yet for this article.
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27581582/breastfeeding-and-protein-intake-influence-body-mass-index-from-2-months-to-22-years-in-the-cebu-longitudinal-health-and-nutrition-survey
#18
Melecia Wright, Michelle Ann Mendez, Daniela Sotres-Alvarez, Linda Adair
BACKGROUND: Protein intake (PI) may alter adiposity but few studies have explored the age-specific associations of PI with body mass index (BMI). OBJECTIVE: We analyzed how PI and breastfeeding relate to BMI in the CLHNS (Cebu Longitudinal Health and Nutrition Survey), an observational Filipino birth cohort (1983-2005). METHODS: Random-effects longitudinal regression models estimated the association of daily breastfeeding frequency and energy-adjusted PI residuals with concurrent BMI z scores (zBMI) measured bimonthly from 2 to 24 mo (n = 2899), and the association of breastfeeding history and PI residuals with concurrent BMI using 5 surveys from 2 to 22 y (n = 2435)...
October 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27575845/cancer-screening-recommendations-for-solid-organ-transplant-recipients-a-systematic-review-of-clinical-practice-guidelines
#19
S A Acuna, J W Huang, A L Scott, S Micic, C Daly, C Brezden-Masley, S J Kim, N N Baxter
Solid organ transplant recipients (SOTRs) are at increased risk of developing and dying from cancer. However, controversies exist around cancer screening in this population owing to reduced life expectancy and competing causes of death. This systematic review assesses the availability, quality and consistency of cancer screening recommendations in clinical practice guidelines (CPGs). We systematically searched bibliographic databases and gray literature to identify CPGs and assessed their quality using AGREE II...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/27552351/the-effects-of-exercise-and-sport-in-solid-organ-transplant-recipients-a-review
#20
Jill Neale, Alice C Smith, Nicolette C Bishop
Solid organ transplantation is the criterion standard treatment for many with end-organ failure and can offer a new independence from the burden of disease. However solid organ transplant recipients (SOTRs) remain at high risk of cardiovascular (CV) disease, and poor quality of life and physical functioning. Increasing physical activity and exercise can improve the health of the general population; however, the effects on those with a transplant remain unclear. Intensive exercise and sporting activity has the potential to be beneficial, although there remain concerns particularly around the effects on immune function and the CV system...
August 22, 2016: American Journal of Physical Medicine & Rehabilitation
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