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Eosinophilic oesophagitis

E Ten Velde, B C Gonera-de Jong
In this case report we discuss two children with dysphagia. Both presented with difficulties in swallowing and oesophageal impaction of solid food. The first case involves a 16-year-old boy who suffered from dysphagia for many years. After a long diagnostic journey, during which a psychogenic cause was suspected, he was diagnosed with oesophageal achalasia. After a balloon dilatation of the lower oesophageal sphincter his complaints persisted and the treatment procedure was repeated. The second case involves a 15-year-old girl, who presented with a food impaction in the distal oesophagus...
2016: Nederlands Tijdschrift Voor Geneeskunde
Pelin Özdemir, Münevver Erdinç, Rukiye Vardar, Ali Veral, Serdar Akyıldız, Özer Özdemir, Serhat Bor
Background/Aims: Gastroesophageal reflux disease (GERD) is one of the main causes of chronic cough. We evaluated the role of microaspiration in the pathogenesis of reflux-related cough by determining the amount of lipid-laden macrophages in bronchoalveolar lavage specimens. Methods: A total of 161 cases of chronic cough were evaluated, and 36 patients (average age 48.2 years) were recruited for this single center prospective study. Patients with a history of smoking, angiotensin converting enzyme inhibitor usage, any abnormality on pulmonary function tests, abnormal chest X-ray, occupational or environmental exposures, or upper airway cough syndrome were excluded...
September 8, 2016: Journal of Neurogastroenterology and Motility
L Á Echeverría-Zudaire, S Fernández-Fernández, A Rayo-Fernández, C Muñóz-Archidona, R Checa-Rodriguez
BACKGROUND: Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL AND METHODS: A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg...
August 31, 2016: Allergologia et Immunopathologia
C A Rubio, T Ichiya, P T Schmidt
AIMS: To report four histological-immunohistochemical oesophagitis phenotypes. METHODS: Oesophageal biopsies from 311 patients were stained with H&E and with CD3, a T cell marker. Additional immunohistochemical stains (n=413) were performed in 77 cases. RESULTS: Four histological-immunohistochemical oesophagitis phenotypes were recorded: lymphocytic oesophagitis (LyE, ≥40 CD3+ lymphocytes/HPF in CD3 immunostain), eosinophilic oesophagitis (EoE, ≥15 eosinophils/HPF in H&E stain), lymphocytic infiltration (≤39 CD3+/HPF) and compound lymphocytic oesophagitis-eosinophilic oesophagitis (Co LyE-EoE)...
July 28, 2016: Journal of Clinical Pathology
Anna L Paterson, Pierre Lao-Sirieix, Maria O'Donovan, Irene Debiram-Beecham, Massimiliano di Pietro, Ahmad Miremadi, Stephen E Attwood, Fiona M Walter, Peter D Sasieni, Rebecca C Fitzgerald
AIMS: Reflux symptoms are highly prevalent and non-specific hence, in the absence of alarm symptoms, endoscopy referral decisions are challenging. This study evaluated whether a non-endoscopic Cytosponge could detect benign oesophageal pathologies and thus have future potential in triaging patients with persistent symptoms. METHODS AND RESULTS: Two complementary cohorts were recruited: 1) Patients with reflux symptoms and no prior endoscopy (n=409); 2) Patients with reflux symptoms referred for endoscopy (n=411)...
July 15, 2016: Histopathology
Aaron S Bancil, Rhys Hewett, Jamal O Hayat, Andrew Poullis
Eosinophilic oesophagitis is a chronic immune-mediated inflammatory disorder of the oesophagus, characterized by symptoms of dysphagia or food bolus obstruction. Diagnosis is supported by typical histological findings. This article covers pertinent aspects of the disease, pathogenic explanations and treatment options.
July 2016: British Journal of Hospital Medicine
E V Savarino, S Tolone, O Bartolo, C de Cassan, R Caccaro, F Galeazzi, L Nicoletti, R Salvador, M Martinato, M Costantini, V Savarino
BACKGROUND: Little is known about the relationship between proton pump inhibitor-responsive oesophageal eosinophilia (PPI-REE), eosinophilic esophagitis (EoE) and gastro-oesophageal reflux disease (GERD). AIM: To compare high resolution manometry features and symptom profiles of patients with EoE, PPI-REE and GERD. METHODS: Consecutive patients diagnosed with EoE or PPI-REE according to international criteria (presence of at least one typical symptom of oesophageal dysfunction; at least 15 eosinophils per high-power field at mid/proximal oesophagus, persistence or resolution of eosinophils after an 8-week PPI trial), and a group of patients with proven GERD and oesophageal eosinophilia, prospectively completed the GerdQ questionnaire and underwent high resolution manometry...
September 2016: Alimentary Pharmacology & Therapeutics
H Philpott, P R Gibson
No abstract text is available yet for this article.
July 2016: Alimentary Pharmacology & Therapeutics
R D Frazier, R Fass
No abstract text is available yet for this article.
July 2016: Alimentary Pharmacology & Therapeutics
Salvatore Oliva, Danilo Rossetti, Paola Papoff, Antonio Tiberti, Paolo Rossi, Sara Isoldi, Jorge Amil Dias, Sandra Lucarelli, Salvatore Cucchiara
BACKGROUND: Oral Viscous Budesonide (OVB) is a recent therapeutic option for Eosinophilic Oesophagitis (EoE) versus dietary restriction and inhaled steroids. This single center, open label, not blinded study aims to evaluate the efficacy and safety of a new, pre-prepared oral viscous budesonide suspension (PVB) in children and adolescents with EoE. METHODS: We treated with PVB 36 children (29 male; median age 12 years) with EoE diagnosed according to ESPGHAN guidelines...
June 2, 2016: Journal of Pediatric Gastroenterology and Nutrition
H Philpott, S Nandurkar, S G Royce, F Thien, P R Gibson
BACKGROUND: The use of allergy tests to guide dietary treatment for eosinophilic oesophagitis (EoE) is controversial and data are limited. Aeroallergen sensitisation patterns and food triggers have been defined in Northern Hemisphere cohorts only. AIMS: To determine if allergy tests that are routinely available can predict food triggers in adult patients with EoE. To define the food triggers and aeroallergen sensitisation patterns in a novel Southern Hemisphere (Australian) cohort of patients...
August 2016: Alimentary Pharmacology & Therapeutics
D Belsha, R Bremner, M Thomson
Endoscopic examination of the gastrointestinal tract (GIT) for diagnostics and therapy in children has evolved markedly over the last 20 or so years and is now usually undertaken by paediatric endoscopists. Updated diagnostic and management guidelines for common disorders including coeliac disease, gastro-oesophageal reflux disease, eosinophilic oesophagitis and inflammatory bowel disease highlight the central role of endoscopy. Therapeutic endoscopic approaches are also now widely available and further broaden the referral spectrum to include treatment of GIT bleeding, gastrostomy insertion, dilation of strictures and polypectomy...
May 31, 2016: Archives of Disease in Childhood
Iago Rodríguez-Lago, Ángel Calderón, Juan Cazallas, María Eulalia Camino, Inmaculada Barredo, José Luis Cabriada
No abstract text is available yet for this article.
May 27, 2016: Gastroenterología y Hepatología
E S Dellon, L L Higgins, R Beitia, S Rusin, J T Woosley, R Veerappan, S R Selitsky, J S Parker, R M Genta, R H Lash, R Aranda, R J Peach, M Grimm
BACKGROUND: Periostin is highly expressed in eosinophilic oesophagitis (EoE), but has not been extensively studied as a non-invasive biomarker. AIM: To assess whether serum periostin distinguished EoE from controls at baseline, had utility for monitoring treatment response, or was associated with IL-13 levels. METHODS: This was a sub-analysis of a prospective cohort study of adults undergoing out-patient upper endoscopy. Incident cases of EoE were diagnosed per consensus guidelines...
July 2016: Alimentary Pharmacology & Therapeutics
J E Richter
No abstract text is available yet for this article.
June 2016: Alimentary Pharmacology & Therapeutics
R Abdul Rani, F R Hussin, A H Hamzaini, M R Isa, R A Raja Ali
Cronkhite-Canada Syndrome (CCS) is a syndrome characterised by a constellation of signs including but not limited to onychodystrophy of the finger and toe nails, skin hyperpigmentation and alopecia. Endoscopic features showed hamartomatous polyps involving all segments of the gastrointestinal tract with the characteristic exception of being oesophageal sparring. These polyps show confirmation by the presence of eosinophils and mast cells at the lamina propria upon histological studies.
February 2016: Medical Journal of Malaysia
Carlos A Rubio, Elisabeth Villnow, Peter T Schmidt
BACKGROUND/AIM: Lymphocytic oesophagitis (LyE) is a newly described entity characterized by a high number of intraepithelial lymphocytes/ high power field (≥40 CD3+IELs/HPF) in the oesophageal epithelium. The aim of the study was to investigate possible ultrastructural changes taking place in LyE at the transmission electron microscopic (TEM) level. MATERIALS AND METHODS: Oesopageal biopsies from seven patients were investigated: four were consecutive patients with LyE, one with reflux oesopagitis, one with eosinophilic oesopagitis (EoE) and one with histologically normal squamous epithelium...
May 2016: Anticancer Research
R Fang, B D Wagner, J K Harris, S A Fillon
Altered microbial communities are thought to play an important role in eosinophilic oesophagitis, an allergic inflammatory condition of the oesophagus. Identification of the majority of organisms present in human-associated microbial communities is feasible with the advent of high throughput sequencing technology. However, these data consist of non-negative, highly skewed sequence counts with a large proportion of zeros. In addition, hierarchical study designs are often performed with repeated measurements or multiple samples collected from the same subject, thus requiring approaches to account for within-subject variation, yet only a small number of microbiota studies have applied hierarchical regression models...
August 2016: Epidemiology and Infection
A Podboy, D A Katzka, F Enders, J J Larson, D Geno, L Kryzer, J Alexander
BACKGROUND: To date there have been no clear features that aid in differentiating patients with eosinophilic oesophagitis (EoE) from PPI-responsive oesophageal eosinophilia (PPI-REE). However, barium swallow roentgenography is a more sensitive and specific measure to detect subtle fibrostenotic remodeling changes present in EoE. We aim to characterise any clinical, endoscopic, histiological or barium roentgenographic differences between EoE and PPI-REE. AIM: To characterise any clinical, endoscopic, histiological or barium roentgenographic differences between EoE and PPI-REE...
June 2016: Alimentary Pharmacology & Therapeutics
Li Nien Michelle Tan, Supriya Srivastava, Ming Teh, Seng Hock Quak, Marion M Aw
INTRODUCTION: We aimed to determine the prevalence and clinical manifestations of eosinophilic oesophagitis (EoE) in children who presented to a tertiary care hospital in Singapore. METHODS: We conducted a retrospective review of all oesophageal biopsies taken during oesophagogastroduodenoscopy (OGD) from March 2010 to December 2011. The patients' demographics and clinical characteristics were collected. Biopsies were reviewed by a single pathologist (who was blinded to the original reports) using the current consensus criteria for the histological diagnosis of EoE...
March 15, 2016: Singapore Medical Journal
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