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M E Galarraga-Vinueza, J Mesquita-Guimarães, R S Magini, J C M Souza, M C Fredel, A R Boccaccini
Bioactive glasses (BGs) are promising materials for bone repair due to their desirable properties such as osteoconductivity, biodegradability, angiogenic potential, and antibacterial activity. Ionic dissolution products from bioactive glasses increase the medium pH reducing surrounding bacteria proliferation. The activity of BGs against biofilm formation has been enhanced by incorporating organic antibacterial compounds. The aim of this review was to summarize evidence in literature which assesses the efficacy of antibacterial and anti-biofilm compounds embedded in bioactive glasses to prevent peri-implant infection during bone healing...
October 17, 2016: Journal of Biomedical Materials Research. Part A
A I Soipe, H Razavi, D Razavi-Shearer, O Galárraga, L E Taylor, B D L Marshall
We utilized a disease progression model to predict the number of viraemic infections, cirrhotic cases, and liver-related deaths in the state of Rhode Island (RI) under four treatment scenarios: (1) current HCV treatment paradigm (about 215 patients treated annually, Medicaid reimbursement criteria fibrosis stage ⩾F3); (2) immediate scale-up of treatment (to 430 annually) and less restrictive Medicaid reimbursement criteria (fibrosis stage ⩾F2); (3) immediate treatment scale-up and no fibrosis stage-specific Medicaid reimbursement criteria (⩾F0); (4) an 'elimination' scenario (i...
August 5, 2016: Epidemiology and Infection
Eduardo Menti, Denise Zaffari, Thais Galarraga, João Regis da Conceição E Lessa, Bruna Pontin, Lucia Campos Pellanda, Vera Lúcia Portal
BACKGROUND: Excessive weight is a cardiovascular risk factor since it generates a chronic inflammatory process that aggravates the endothelial function. OBJECTIVE: To evaluate the endothelial function in individuals with excess weight and mild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), and the association of endothelial function with anthropometric and biochemical variables. METHODS: Cross-sectional study that included 74 individuals and evaluated anthropometric variables (body mass index [BMI], waist-hip ratio [WHR], waist circumference [AC], and percentage of body fat [PBF]), biochemical (blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen, total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) and endothelial function (BAFMD, evaluated by ultrasound)...
June 2016: Arquivos Brasileiros de Cardiologia
Andrew R Zullo, Chanelle J Howe, Omar Galárraga
Personal prescription drug importation occurs in the United States because of the high cost of U.S. medicines and lower cost of foreign equivalents. Importation carries a risk of exposure to counterfeit (i.e., falsified, fraudulent), adulterated, and substandard drugs. Inadequate health insurance may increase the risk of importation. We use inverse probability weighted marginal structural models and data on 87,494 individuals from the 2011-2013 National Health Interview Survey to estimate the marginal association between no health insurance and importation within U...
February 2, 2016: Medical Care Research and Review: MCRR
Jessica E Galarraga, Jesse M Pines
BACKGROUND: Emergency department (ED) care is a focus of cost reduction efforts. Costs for acute care originating in the ED, including outpatient and inpatient encounters (i.e. ED episodes), have not been estimated. OBJECTIVE: We estimate total US costs of ED episodes, potentially avoidable costs, and proportional costs of national health expenditures (NHEs). METHODS: We conducted a secondary analysis of 2010 data from the Medical Expenditure Panel Survey, National Hospital Ambulatory Medical Care Survey, and the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample...
March 2016: American Journal of Emergency Medicine
O A Galarraga C, V Vigneron, B Dorizzi, N Khouri, E Desailly
No abstract text is available yet for this article.
2015: Computer Methods in Biomechanics and Biomedical Engineering
Kristen Underhill, Kathleen M Morrow, Christopher Colleran, Richard Holcomb, Sarah K Calabrese, Don Operario, Omar Galárraga, Kenneth H Mayer
Access to biomedical HIV prevention technologies such as pre-exposure prophylaxis (PrEP) requires individuals to disclose risk behavior to clinicians, but experiences of discrimination and medical mistrust may limit disclosure among male sex workers and other MSM. We explored experiences of perceived discrimination, medical mistrust, and behavior disclosure among male sex workers compared to other men who have sex with men (MSM). We conducted 56 interviews with MSM and compared findings about medical mistrust, discrimination, and disclosure for 31 men who engaged in sex work vs...
August 2015: Journal of Urban Health: Bulletin of the New York Academy of Medicine
Ricardo Hernández-Martínez, José J Aceves, Pavel E Rueda-Orozco, Teresa Hernández-Flores, Omar Hernández-González, Dagoberto Tapia, Elvira Galarraga, José Bargas
The external globus pallidus (GPe) is central for basal ganglia processing. It expresses muscarinic cholinergic receptors and receives cholinergic afferents from the pedunculopontine nuclei (PPN) and other regions. The role of these receptors and afferents is unknown. Muscarinic M1-type receptors are expressed by synapses from striatal projection neurons (SPNs). Because axons from SPNs project to the GPe, one hypothesis is that striatopallidal GABAergic terminals may be modulated by M1 receptors. Alternatively, some M1 receptors may be postsynaptic in some pallidal neurons...
February 1, 2015: Journal of Neurophysiology
P de Toledo, M Galarraga, I Martinez, L Serrano, J Fernandez, F Del Pozo
The expansion of e-Health solutions is hindered by the high costs and low flexibility of home and mobile telemonitoring systems. This situation may be improved by the use of standards to design open, plug-and-play and interoperable devices. This work describes the joint efforts of three research groups in Spain towards the interoperability of their telemonitoring solutions based on the ISO11073/IEEE1073 family of standards.
August 2006: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Elizabeth N Kinnard, Lynn E Taylor, Omar Galárraga, Brandon D L Marshall
Although there is a large health, social, and economic burden of hepatitis C virus (HCV) infection in the United States, the number of persons infected with HCV in Rhode Island (RI) is unknown. To inform the expansion of HCV-related public health efforts in RI, and because surveillance data are lacking and national surveys, including the National Health and Nutrition Examination Survey (NHANES), likely underestimate true HCV prevalence, we reviewed published peer-reviewed and grey literature to more accurately estimate the prevalence of HCV in RI...
July 2014: Rhode Island Medical Journal
I Jáuregui Presa, M Varona Peinador, M Pérez Bea, M C Espallargas Ruiz-Ogarrio, P M Gamboa Setién, E García Lirio, A M Soriano Galarraga, I Antépara Ercoreca, M Martínez Ortiz de Zárate
No abstract text is available yet for this article.
2013: Journal of Investigational Allergology & Clinical Immunology
Jessica E Galarraga, Jesse M Pines
STUDY OBJECTIVE: We study how reimbursements to emergency departments (EDs) for outpatient visits may be affected by the insurance coverage expansion of the Patient Protection and Affordable Care Act as previously uninsured patients gain coverage either through the Medicaid expansion or through health insurance exchanges. METHODS: We conducted a secondary analysis of data (2005 to 2010) from the Medical Expenditure Panel Survey. We specified multiple linear regression models to examine differences in the payments, charges, and reimbursement ratios by insurance category...
April 2014: Annals of Emergency Medicine
Víctor Plata, Mariana Duhne, Jesús E Pérez-Ortega, Janet Barroso-Flores, Elvira Galarraga, José Bargas
Physiological and biochemical experiments in vivo and in vitro have explored striatal receptor signaling and neuronal excitability to posit pathophysiological models of Parkinson's disease. However, when therapeutic approaches, such as dopamine agonists, need to be evaluated, behavioral tests using animal models of Parkinson's disease are employed. To our knowledge, recordings of population neuronal activity in vitro to assess anti-Parkinsonian drugs and the correlation of circuit dynamics with disease state have only recently been attempted...
2013: BioMed Research International
Mario A Arias-García, Dagoberto Tapia, Edén Flores-Barrera, Jesús E Pérez-Ortega, José Bargas, Elvira Galarraga
The firing of striatal projection neurons (SPNs) exhibits afterhyperpolarizing potentials (AHPs) that determine discharge frequency. They are in part generated by Ca(2+)-activated K(+)-currents involving BK and SK components. It has previously been shown that suprathreshold corticostriatal responses are more prolonged and evoke more action potentials in direct pathway SPNs (dSPNs) than in indirect pathway SPNs (iSPNs). In contrast, iSPNs generate dendritic autoregenerative responses. Using whole cell recordings in brain slices, we asked whether the participation of Ca(2+)-activated K(+)-currents plays a role in these responses...
2013: Frontiers in Systems Neuroscience
O Hernández-González, T Hernández-Flores, G A Prieto, A Pérez-Burgos, M A Arias-García, E Galarraga, J Bargas
D(1)- and D(2)-types of dopamine receptors are located separately in direct and indirect pathway striatal projection neurons (dSPNs and iSPNs). In comparison, adenosine A(1)-type receptors are located in both neuron classes, and adenosine A(2A)-type receptors show a preferential expression in iSPNs. Due to their importance for neuronal excitability, Ca(2+)-currents have been used as final effectors to see the function of signaling cascades associated with different G protein-coupled receptors. For example, among many other actions, D(1)-type receptors increase, while D(2)-type receptors decrease neuronal excitability by either enhancing or reducing, respectively, CaV1 Ca(2+)-currents...
2014: Purinergic Signalling
Bianca J Vizcarra-Chacón, Mario A Arias-García, Maria B Pérez-Ramírez, Edén Flores-Barrera, Dagoberto Tapia, Rene Drucker-Colin, José Bargas, Elvira Galarraga
BACKGROUND: Previous work showed differences in the polysynaptic activation of GABAergic synapses during corticostriatal suprathreshold responses in direct and indirect striatal projection neurons (dSPNs and iSPNs). Here, we now show differences and similarities in the polysynaptic activation of cortical glutamatergic synapses on the same responses. Corticostriatal contacts have been extensively studied. However, several questions remain unanswered, e.g.: what are the differences and similarities in the responses to glutamate in dSPNs and iSPNs? Does glutamatergic synaptic activation exhibits a distribution of latencies over time in vitro? That would be a strong suggestion of polysynaptic cortical convergence...
2013: BMC Neuroscience
F M Kovacs, E Arana, A Royuela, A Estremera, G Amengual, B Asenjo, H Sarasíbar, I Galarraga, A Alonso, C Casillas, A Muriel, C Martínez, V Abraira
BACKGROUND AND PURPOSE: Data on the association between vertebral endplate changes and low back pain are contradictory. This study was designed to assess whether this association exists among Southern European subjects. MATERIALS AND METHODS: Patients in this study serving as cases were 35-50 years of age with low back pain lasting >90 days, for whom a lumbar MR imaging had been prescribed. Controls were subjects 35-50 years of age, having a cranial MR imaging for headache with normal findings, and no history of clinically relevant LBP...
September 2012: AJNR. American Journal of Neuroradiology
A Herrero Varas, I San Martín García, L Moreno Galarraga, M Herranz Aguirre, J C García Romero, E Bernaola Iturbe
We present the case of 9 year old male referred to the A and E service with right ocular proptosis and progressive migraine in the context of a sinusitis diagnosed two days earlier by compatible clinical and radiological tests, and receiving treatment with amoxicillin-clavulanic acid. Physcial exploration revealed right ocular proptosis with a slight limitation for conjugate gaze. Facing the suspicion of a possible neurological complication of the sinusitis, cranial computer aided tomography (CAT) was carried out, with right frontal subdural empyema observed...
September 2011: Anales del Sistema Sanitario de Navarra
Jason D Graci, Nina F Gnädig, Jessica E Galarraga, Christian Castro, Marco Vignuzzi, Craig E Cameron
The ability to extinguish a viral population of fixed reproductive capacity by causing small changes in the mutation rate is referred to as lethal mutagenesis and is a corollary of population genetics theory. Here we show that coxsackievirus B3 (CVB3) exhibits reduced mutational robustness relative to poliovirus, manifesting in enhanced sensitivity of CVB3 to lethal mutagens that is dependent on the size of the viral population. We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis...
March 2012: Journal of Virology
Jose J Aceves, Pavel E Rueda-Orozco, Ricardo Hernandez-Martinez, Elvira Galarraga, Jose Bargas
There is no hypothesis to explain how direct and indirect basal ganglia (BG) pathways interact to reach a balance during the learning of motor procedures. Both pathways converge in the substantia nigra pars reticulata (SNr) carrying the result of striatal processing. Unfortunately, the mechanisms that regulate synaptic plasticity in striatonigral (direct pathway) synapses are not known. Here, we used electrophysiological techniques to describe dopamine D(1)-receptor-mediated facilitation in striatonigral synapses in the context of its interaction with glutamatergic inputs, probably coming from the subthalamic nucleus (STN) (indirect pathway) and describe a striatonigral cannabinoid-dependent long-term synaptic depression (LTD)...
December 2011: Learning & Memory
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