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https://www.readbyqxmd.com/read/28514280/ten-year-trends-in-anti-retroviral-therapy-persistence-among-us-medicaid-beneficiaries-2001-2010
#1
Bora Youn, Theresa I Shireman, Yoojin Lee, Omar Galárraga, Aadia I Rana, Amy C Justice, Ira B Wilson
OBJECTIVE: Whether the rate of HIV antiretroviral therapy (ART) persistence has improved over time in the U.S. is unknown. We examined ART persistence trends between 2001 and 2010, using non-HIV medications as a comparator. METHODS: We conducted a retrospective cohort study using Medicaid claims. We defined persistence as the duration of treatment from the first to the last fill date before a 90-day permissible gap, and used Kaplan-Meier curves and Cox proportional hazard models to assess crude and adjusted non-persistence...
May 16, 2017: AIDS
https://www.readbyqxmd.com/read/28435119/linear-accelerator-stereotactic-radiosurgery-of-central-nervous-system-arteriovenous-malformations-a-15-year-analysis-of-outcome-related-factors-in-a-single-tertiary-center
#2
José Luis Thenier-Villa, Raúl Alejandro Galárraga-Campoverde, Rosa María Martínez Rolán, Adolfo Ramón De La Lama Zaragoza, Pedro Martínez Cueto, Víctor Muñoz Garzón, Manuel Salgado Fernández, Cesáreo Conde Alonso
No abstract text is available yet for this article.
April 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28410917/the-relative-contribution-of-provider-and-ed-level-factors-to-variation-among-the-top-15-reasons-for-ed-admission
#3
Imad Khojah, Suhui Li, Qian Luo, Griffin Davis, Jessica E Galarraga, Michael Granovsky, Ori Litvak, Samuel Davis, Robert Shesser, Jesse M Pines
STUDY OBJECTIVE: We examine adult emergency department (ED) admission rates for the top 15 most frequently admitted conditions, and assess the relative contribution in admission rate variation attributable to the provider and hospital. METHODS: This was a retrospective, cross-sectional study of ED encounters (≥18years) from 19 EDs and 603 providers (January 2012-December 2013), linked to the Area Health Resources File for county-level information on healthcare resources...
April 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28364569/improving-antiretroviral-therapy-adherence-in-resource-limited-settings-at-scale-a-discussion-of-interventions-and-recommendations
#4
Jessica E Haberer, Lora Sabin, K Rivet Amico, Catherine Orrell, Omar Galárraga, Alexander C Tsai, Rachel C Vreeman, Ira Wilson, Nadia A Sam-Agudu, Terrence F Blaschke, Bernard Vrijens, Claude A Mellins, Robert H Remien, Sheri D Weiser, Elizabeth Lowenthal, Michael J Stirratt, Papa Salif Sow, Bruce Thomas, Nathan Ford, Edward Mills, Richard Lester, Jean B Nachega, Bosco Mwebesa Bwana, Fred Ssewamala, Lawrence Mbuagbaw, Paula Munderi, Elvin Geng, David R Bangsberg
INTRODUCTION: Successful population-level antiretroviral therapy (ART) adherence will be necessary to realize both the clinical and prevention benefits of antiretroviral scale-up and, ultimately, the end of AIDS. Although many people living with HIV are adhering well, others struggle and most are likely to experience challenges in adherence that may threaten virologic suppression at some point during lifelong therapy. Despite the importance of ART adherence, supportive interventions have generally not been implemented at scale...
March 22, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28351364/task-shifting-alcohol-interventions-for-hiv-persons-in-kenya-a-cost-benefit-analysis
#5
Omar Galárraga, Burke Gao, Benson N Gakinya, Debra A Klein, Richard G Wamai, John E Sidle, Rebecca K Papas
BACKGROUND: Among HIV+ patients, alcohol use is a highly prevalent risk factor for both HIV transmission and poor adherence to HIV treatment. The large-scale implementation of effective interventions for treating alcohol problems remains a challenge in low-income countries with generalized HIV epidemics. It is essential to consider an intervention's cost-effectiveness in dollars-per-health-outcome, and the long-term economic impact -or "return on investment" in monetary terms. METHODS: We conducted a cost-benefit analysis, measuring economic return on investment, of a task-shifted cognitive-behavioral therapy (CBT) intervention delivered by paraprofessionals to reduce alcohol use in a modeled cohort of 13,440 outpatients in Kenya...
March 28, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28304386/effect-of-pregnancy-in-myopia-progression-the-sun-cohort
#6
A Fernández-Montero, M Bes-Rastrollo, J Moreno-Montañés, L Moreno-Galarraga, M Á Martínez-González
PurposePrevious studies have suggested that pregnancy may induce myopia progression. However, no longitudinal study with a large sample size and long-term follow-up has assessed this association. Our objective was to investigate whether pregnancy was related to mid- or long-term myopic refraction changes.Patients and methodsA prospective study was conducted in a Mediterranean cohort. The study included 10 401 women (20-50 years old) from the SUN Project. SUN project is a multipurpose, prospective, and dynamic cohort of university graduates conducted in Spain...
March 17, 2017: Eye
https://www.readbyqxmd.com/read/28263451/inhibition-of-multi-species-oral-biofilm-by-bromide-doped-bioactive-glass
#7
M E Galarraga-Vinueza, B Passoni, C A M Benfatti, J Mesquita-Guimarães, B Henriques, R S Magini, M C Fredel, B V Meerbeek, W Teughels, J C M Souza
Bioactive glass is an attractive biomaterial that has shown excellent osteogenic and angiogenic effects for oral bone repairing procedures. However, anti-biofilm potential related to such biomaterial has not been completely validated, mainly against multi-species biofilms involved in early tissue infections. The aim of the present study was to evaluate the anti-biofilm effect of 58S bioactive glass embedding calcium bromide compounds at different concentrations. Bioactive glass containing 0, 5, or 10wt% CaBr2 was synthesized by alkali sol-gel method and then characterized by physco-chemical and scanning electron microscopy (SEM)...
March 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28207060/do-national-drug-policies-influence-antiretroviral-drug-prices-evidence-from-the-southern-african-development-community
#8
Yao Liu, Omar Galárraga
No abstract text is available yet for this article.
March 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28185745/how-emergency-department-ed-admission-decisions-differ-when-the-same-physician-works-in-two-different-eds
#9
Jesse M Pines, Jessica E Galarraga, Michael Granvosky, Ori Litvak, Samuel Davis, Leah Honigman Warner
STUDY OBJECTIVE: Emergency physicians often work in multiple hospital emergency departments (EDs). We study how emergency physician admission decisions vary in different settings. METHODS: We conducted a retrospective, cross-sectional study over two years (2012-3) in six EDs in three states. Included physicians had ≥200 encounters per site in two different EDs. "Admissions" were ED encounters resulting in admission to the hospital or transfer to another hospital...
February 2, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28110864/sexual-behavior-among-orphaned-adolescents-in-western-kenya-a-comparison-of-institutional-and-family-based-care-settings
#10
Lonnie Embleton, Joram Nyandat, David Ayuku, Edwin Sang, Allan Kamanda, Samuel Ayaya, Winstone Nyandiko, Peter Gisore, Rachel Vreeman, Lukoye Atwoli, Omar Galarraga, Mary A Ott, Paula Braitstein
PURPOSE: This study sought to assess whether risky sexual behaviors and sexual exploitation of orphaned adolescents differed between family-based and institutional care environments in Uasin Gishu County, Kenya. METHODS: We analyzed baseline data from a cohort of orphaned adolescents aged 10-18 years living in 300 randomly selected households and 19 charitable children's institutions. The primary outcomes were having ever had consensual sex, number of sex partners, transactional sex, and forced sex...
April 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28069845/at-federally-funded-health-centers-medicaid-expansion-was-associated-with-improved-quality-of-care
#11
Megan B Cole, Omar Galárraga, Ira B Wilson, Brad Wright, Amal N Trivedi
In 2014 many uninsured, low-income nonelderly adults gained access to health insurance in states that expanded Medicaid eligibility under the Affordable Care Act. Federally funded community health centers were likely to be particularly affected by this expansion because many of their patients were uninsured and low income. We used a difference-in-differences approach to compare changes among 1,057 such centers in expansion versus nonexpansion states from 2011 to 2014, in terms of their patients' insurance coverage, the number of patients they served, and the quality of care they provided...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/27974611/activation-of-glutamatergic-fibers-in-the-anterior-nac-shell-modulates-reward-activity-in-the-anacsh-the-lateral-hypothalamus-and-medial-prefrontal-cortex-and-transiently-stops-feeding
#12
Luis Prado, Jorge Luis-Islas, Osvaldo I Sandoval, Liliana Puron, Moreno M Gil, Alvaro Luna, Mario A Arias-García, Elvira Galarraga, Sidney A Simon, Ranier Gutierrez
Although the release of mesoaccumbal dopamine is certainly involved in rewarding responses, recent studies point to the importance of the interaction between it and glutamate. One important component of this network is the anterior nucleus accumbens shell (aNAcSh), which sends GABAergic projections into the lateral hypothalamus (LH) and receives extensive glutamatergic inputs from, among others, the medial prefrontal cortex (mPFC). The effects of glutamatergic activation of aNAcSh on the ingestion of rewarding stimuli as well as its effect in the LH and mPFC are not well understood...
December 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27902652/circulating-antibody-1-and-2-years-after-vaccination-with-the-13-valent-pneumococcal-conjugate-vaccine-in-preterm-compared-with-term-infants
#13
Federico Martinón-Torres, Jacek Wysocki, Kimberly J Center, Hanna Czajka, Ewa Majda-Stanislawska, Felix Omeñaca, Ana Concheiro-Guisan, Francisco Gimenez-Sanchez, Leszek Szenborn, Daniel Blázquez-Gamero, Laura Moreno-Galarraga, Peter C Giardina, Gang Sun, William C Gruber, Daniel A Scott, Alejandra Gurtman
BACKGROUND: Premature infants have lower short-term immune responses to vaccination than term infants, but patterns of antibody persistence in preterm infants over longer periods are not well established. This study assessed the persistence of antibody response to the 13-valent pneumococcal conjugate vaccine (PCV13) in formerly preterm versus term infants. METHODS: In total, 100 preterm and 100 term infants received PCV13 with routine vaccines at ages 2, 3, 4 and 12 months...
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27871017/predicting-postoperative-gait-in-cerebral-palsy
#14
Omar A Galarraga C, Vincent Vigneron, Bernadette Dorizzi, Néjib Khouri, Eric Desailly
In this work, postoperative lower limb kinematics are predicted with respect to preoperative kinematics, physical examination and surgery data. Data of 115 children with cerebral palsy that have undergone single-event multilevel surgery were considered. Preoperative data dimension was reduced utilizing principal component analysis. Then, multiple linear regressions with 80% confidence intervals were performed between postoperative kinematics and bilateral preoperative kinematics, 36 physical examination variables and combinations of 9 different surgical procedures...
November 9, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27753679/costs-along-the-service-cascades-for-hiv-testing-and-counselling-and-prevention-of-mother-to-child-transmission
#15
Sergio Bautista-Arredondo, Sandra G Sosa-Rubí, Marjorie Opuni, David Contreras-Loya, Ada Kwan, Claire Chaumont, Abson Chompolola, Jeanine Condo, Omar Galárraga, Neil Martinson, Felix Masiye, Sabin Nsanzimana, Ivan Ochoa-Moreno, Richard Wamai, Joseph Wang'ombe
OBJECTIVE: We estimate facility-level average annual costs per client along the HIV testing and counselling (HTC) and prevention of mother-to-child transmission (PMTCT) service cascades. DESIGN: Data collected covered the period 2011-2012 in 230 HTC and 212 PMTCT facilities in Kenya, Rwanda, South Africa, and Zambia. METHODS: Input quantities and unit prices were collected, as were output data. Annual economic costs were estimated from the service providers' perspective using micro-costing...
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27750384/anti-biofilm-properties-of-bioactive-glasses-embedding-organic-active-compounds
#16
REVIEW
M E Galarraga-Vinueza, J Mesquita-Guimarães, R S Magini, J C M Souza, M C Fredel, A R Boccaccini
Bioactive glasses (BGs) are promising materials for bone repair due to their desirable properties such as osteoconductivity, biodegradability, angiogenic potential, and antibacterial activity. Ionic dissolution products from bioactive glasses increase the medium pH inhibiting surrounding bacteria proliferation. The activity of BGs against biofilm formation has been enhanced by incorporating organic antibacterial compounds. The aim of this review was to summarize evidence in literature which assesses the efficacy of antibacterial and anti-biofilm compounds embedded in bioactive glasses to prevent peri-implant infection during bone healing...
February 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27591130/do-national-drug-policies-influence-antiretroviral-drug-prices-evidence-from-the-southern-african-development-community
#17
Yao Liu, Omar Galárraga
BACKGROUND: The efficacy of low- and middle-income countries' (LMIC) national drug policies in managing antiretroviral (ARV) pharmaceutical prices is not well understood. Though ARV drug prices have been declining in LMIC over the past decade, little research has been done on the role of their national drug policies. This study aims to (i) analyse global ARV prices from 2004 to 2013 and (ii) examine the relationship of national drug policies to ARV prices. METHODS: Analysis of ARV drug prices utilized data from the Global Price Reporting Mechanism from the World Health Organization (WHO)...
September 1, 2016: Health Policy and Planning
https://www.readbyqxmd.com/read/27580930/predictors-of-morbidity-and-cleavage-plane-in-surgical-resection-of-pure-convexity-meningiomas-using-cerebrospinal-fluid-sensitive-image-subtraction-magnetic-resonance-imaging
#18
José Luis Thenier-Villa, Raúl Alejandro Galárraga Campoverde, Adolfo Ramón DE LA Lama Zaragoza, Cesáreo Conde Alonso
Meningiomas are the most common primary intracranial tumors. Since the adhesions in the plane of dissection are of interest in surgical planning, we suggest that digital image subtraction of FLAIR data from the T2 sequence of MRI may represent better the CSF spaces in the brain-tumor interface and may be a predictor of the intraoperative cleavage plane. From 2006 to 2016, 83 convexity meningiomas were resected in the Department of Neurosurgery of the University Hospital Complex of Vigo, an analysis of preoperative MRI was performed to assess peritumoral edema (PTE), tumor volume, among others; a digital subtraction of T2-FLAIR sequences was performed and analyzed in relationship to the cleavage plane described in the intraoperative report and postoperative neurological deficits...
January 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/27556485/association-between-body-mass-index-waist-to-height-ratio-and-adiposity-in-children-a-systematic-review-and-meta-analysis
#19
REVIEW
Nerea Martin-Calvo, Laura Moreno-Galarraga, Miguel Angel Martinez-Gonzalez
Obesity is defined as an abnormal or excessive fat accumulation that may impair health. Dual-energy X-ray absorptiometry (DEXA) has been suggested as the gold standard to define obesity, but because its use is complex and expensive, anthropometric measures such as body mass index (BMI) or the waist-to-height ratio (WtHr) have been used as alternatives. The aim of this study was to review the published literature and investigate the correlation of BMI and WtHr with body fat (BF) measured by DEXA in pediatric populations...
August 20, 2016: Nutrients
https://www.readbyqxmd.com/read/27492142/chronic-hepatitis-c-virus-hcv-burden-in-rhode-island-modelling-treatment-scale-up-and-elimination
#20
A I Soipe, H Razavi, D Razavi-Shearer, O Galárraga, L E Taylor, B D L Marshall
We utilized a disease progression model to predict the number of viraemic infections, cirrhotic cases, and liver-related deaths in the state of Rhode Island (RI) under four treatment scenarios: (1) current HCV treatment paradigm (about 215 patients treated annually, Medicaid reimbursement criteria fibrosis stage ⩾F3); (2) immediate scale-up of treatment (to 430 annually) and less restrictive Medicaid reimbursement criteria (fibrosis stage ⩾F2); (3) immediate treatment scale-up and no fibrosis stage-specific Medicaid reimbursement criteria (⩾F0); (4) an 'elimination' scenario (i...
August 5, 2016: Epidemiology and Infection
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